| 2020 |
Blackburn, P., Sullivan, A., Gerassimou, A., Kleinendorst, L., Bersten, D., Cooiman, M., . . . Atwal, P. (2020). Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity. The Journal of clinical endocrinology and metabolism, 105(1).
DOI |
| 2017 |
Button, E., Bersten, D., & Whitelaw, M. (2017). HIF has Biff - Crosstalk between HIF1a and the family of bHLH/PAS proteins. Experimental Cell Research, 356(2), 141-145.
DOI Scopus5 WoS4 Europe PMC3 |
| 2017 |
Moir, L., Bochukova, E., Dumbell, R., Banks, G., Bains, R., Nolan, P., . . . Cox, R. (2017). Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6(11), 1419-1428.
DOI Scopus1 WoS1 Europe PMC1 |
| 2016 |
Sullivan, A., Peet, D., & Whitelaw, M. (2016). MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS Journal, 283(18), 3488-3502.
DOI Scopus5 WoS5 Europe PMC3 |
| 2015 |
Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M., . . . Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128(2), 225-231.
DOI Scopus21 WoS22 Europe PMC18 |
| 2015 |
Bersten, D., Sullivan, A., Li, D., Bhakti, V., Bent, S., & Whitelaw, M. (2015). Inducible and reversible lentiviral and recombination mediated cassette exchange (RMCE) systems for controlling gene expression. PLoS One, 10(3), e0116373-1-e0116373-20.
DOI Scopus2 WoS3 Europe PMC2 |
| 2014 |
Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
DOI Scopus6 WoS5 Europe PMC5 |
| 2014 |
Bersten, D., Bruning, J., Peet, D., & Whitelaw, M. (2014). Human variants in the Neuronal Basic Helix-Loop-Helix/ Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One, 9(1), e85768-1-e85768-11.
DOI Scopus15 WoS15 Europe PMC15 |
| 2014 |
Montagne, L., Raimondo, A., Delobel, B., Duban-Bedu, B., Noblet, F., Dechaume, A., . . . Bonnefond, A. (2014). Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay. Obesity, 22(12), 2621-2624.
DOI Scopus13 WoS13 Europe PMC5 |
| 2014 |
Bersten, D., Wright, J., McCarthy, P., & Whitelaw, M. (2014). Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochimica et Biophysica Acta, 1839(1), 13-24.
DOI Scopus17 WoS17 Europe PMC15 |
| 2013 |
Bersten, D., Sullivan, A., Peet, D., & Whitelaw, M. (2013). BHLH-PAS proteins in cancer. Nature Reviews. Cancer, 13(12), 827-841.
DOI Scopus100 WoS94 Europe PMC78 |
| 2013 |
Hao, N., & Whitelaw, M. (2013). The emerging roles of AhR in physiology and immunity. Biochemical Pharmacology, 86(5), 561-570.
DOI Scopus85 WoS82 Europe PMC58 |
| 2013 |
Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D., . . . Froguel, P. (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. Journal of Clinical Investigation, 123(7), 3037-3041.
DOI Scopus52 WoS53 Europe PMC41 |
| 2013 |
Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
DOI Scopus71 WoS66 Europe PMC53 |
| 2013 |
Hao, N., Bhakti, V., Peet, D., & Whitelaw, M. (2013). Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Research, 41(11), 5626-5638.
DOI Scopus16 WoS16 Europe PMC15 |
| 2013 |
Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016). Journal of Clinical Investigation, 123(8), 3635.
DOI |
| 2012 |
Hao, N., Lee, K., Furness, S., Bosdotter, C., Poellinger, L., & Whitelaw, M. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82(6), 1082-1093.
DOI Scopus18 WoS18 Europe PMC15 |
| 2011 |
Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B., & Chapman-Smith, A. (2011). Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Research, 39(9), 3695-3709.
DOI Scopus24 WoS22 Europe PMC22 |
| 2011 |
Cook, A., Vitale, A., Ravishankar, S., Matigian, N., Sutherland, G., Shan, J., . . . Wood, S. (2011). NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's Disease. PLoS One, 6(7), e21907-1-e21907-14.
DOI Scopus53 WoS51 Europe PMC34 |
| 2010 |
Whelan, F., Hao, N., Furness, S., Whitelaw, M., & Chapman-Smith, A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77(6), 1037-1046.
DOI Scopus17 WoS14 Europe PMC12 |
| 2009 |
Farrall, A., & Whitelaw, M. (2009). The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene, 28(41), 3671-3680.
DOI Scopus31 WoS30 Europe PMC27 |
| 2009 |
Dave, K., Whelan, F., Bindloss, C., Furness, S., Chapman-Smith, A., Whitelaw, M., & Gorman, J. (2009). Sulfonation and Phosphorylation of Regions of the Dioxin Receptor Susceptible to Methionine Modifications. Molecular and Cellular Proteomics, 8(4), 706-719.
DOI Scopus11 WoS8 Europe PMC4 |
| 2008 |
Woods, S., Farrall, A., Procko, C., & Whitelaw, M. (2008). The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence. Nucleic Acids Research, 36(11), 3716-3727.
DOI Scopus10 WoS10 Europe PMC9 |
| 2008 |
Zheng, X., Karttunen, S., Dias, J., Zheng, X., Gradin, K., Wallis, T., . . . Poellinger, L. (2008). Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3368-3373.
DOI Scopus169 WoS172 Europe PMC141 |
| 2007 |
Dave, K., Hamilton, B., Wallis, T., Furness, S., Whitelaw, M., & Gorman, J. (2007). Identification of N,Nε-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268(2-3), 168-180.
DOI Scopus10 |
| 2007 |
Furness, S., Lees, M., & Whitelaw, M. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581(19Sp. Iss.), 3616-3625.
DOI Scopus62 Europe PMC47 |
| 2006 |
Bracken, C., Fedele, A., Karttunen, S., Balrak, W., Lisy, K., Whitelaw, M., & Peet, D. (2006). Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment. Journal of Biological Chemistry, 281(32), 22575-22585.
DOI Scopus121 WoS117 Europe PMC88 |
| 2006 |
Chapman-Smith, A., & Whitelaw, M. (2006). Novel DNA binding by a basic helix-loop-helix protein - The role of the dioxin receptor PAS domain. Journal of Biological Chemistry, 281(18), 12535-12545.
DOI Scopus26 WoS24 Europe PMC19 |
| 2005 |
Kewley, R., & Whitelaw, M. (2005). Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator. Biochemical and Biophysical Research Communications, 338(1), 660-667.
DOI Scopus6 Europe PMC5 |
| 2005 |
Bracken, C., Whitelaw, M., & Peet, D. (2005). Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator. Journal of Biological Chemistry, 280(14), 14240-14251.
DOI Scopus53 WoS52 Europe PMC44 |
| 2004 |
Peet, D., Lando, D., Whelan, D., Whitelaw, M., & Gorman, J. (2004). Oxygen-dependent asparagine hydroxylation. Methods in Enzymology, 381, 467-487.
DOI Scopus19 WoS15 Europe PMC9 |
| 2004 |
Kewley, R., Whitelaw, M., & Chapman-Smith, A. (2004). The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. International Journal of Biochemistry & Cell Biology, 36(2), 189-204.
DOI Scopus364 WoS353 Europe PMC265 |
| 2004 |
Karttunen, S., Stojkoski, C., Kewley, R., Booker, G., Whitelaw, M., & Peet, D. (2004). Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. Biological Chemistry, 279(14), 14391-14397.
DOI Scopus66 WoS60 Europe PMC41 |
| 2004 |
Chapman-Smith, A., Lutwyche, J., & Whitelaw, M. (2004). Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. Journal of Biological Chemistry, 279(7), 5353-5362.
DOI Scopus57 WoS54 Europe PMC45 |
| 2004 |
Kaufman, B., Scharf, O., Arbeit, J., Ashcroft, M., Brown, J., Bruick, R., . . . Ivy, S. (2004). Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research, 64(9), 3350-3356.
DOI Scopus27 Europe PMC18 |
| 2003 |
Bracken, C., Whitelaw, M., & Peet, D. (2003). The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cellular and Molecular Life Sciences, 60(7), 1376-1393.
DOI Scopus178 WoS164 Europe PMC128 |
| 2003 |
Lees, M., Peet, D., & Whitelaw, M. (2003). Defining the role for XAP2 in stabilization of the dioxin receptor. Journal of Biological Chemistry, 278(38), 35878-35888.
DOI Scopus68 WoS57 Europe PMC33 |
| 2003 |
Lando, D., Gorman, J., Whitelaw, M., & Peet, D. (2003). Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. FEBS Journal, 270(5), 781-790.
DOI Scopus102 WoS91 Europe PMC62 |
| 2002 |
Fedele, A., Whitelaw, M., & Peet, D. (2002). Regulation of gene expression by the hypoxia-inducible factors. Molecular Interventions, 2(4), 229-243.
DOI Scopus62 Europe PMC40 |
| 2002 |
Lando, D., Peet, D., Pongratz, I., & Whitelaw, M. (2002). Mammalian two-hybrid assay showing redox control of HIF-like factor. Methods in Enzymology, 353, 3-10.
DOI Scopus3 WoS3 Europe PMC1 |
| 2002 |
Swanson, H., Whitelaw, M., Petrulis, J., & Perdew, G. (2002). Use of [¹²⁵I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. Journal of Biochemical and Molecular Toxicology, 16(6), 298-310.
DOI Scopus5 Europe PMC2 |
| 2002 |
Lees, M., & Whitelaw, M. (2002). Effect of ARA9 on dioxin receptor mediated transcription. Toxicology, 181-182, 143-146.
DOI Scopus9 Europe PMC3 |
| 2002 |
Lando, D., Peet, D., Gorman, J., Whelan, D., Whitelaw, M., & Bruick, R. (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes & Development, 16(12), 1466-1471.
DOI Scopus1019 WoS991 Europe PMC733 |
| 2002 |
Woods, S., & Whitelaw, M. (2002). Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element - Cross-talk between basic helix-loop-helix/Per-Arnt-Sim homology transcription factors. Journal of Biological Chemistry, 277(12), 10236-10243.
DOI Scopus54 WoS54 Europe PMC46 |
| 2002 |
Lando, D., Peet, D., Whelan, D., Gorman, J., & Whitelaw, M. (2002). Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science, 295(5556), 858-861.
DOI Scopus1141 WoS1076 Europe PMC745 |
| 2002 |
Andersson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M., Pettersson, S., . . . Poellinger, L. (2002). A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 9990-9995.
DOI Scopus215 Europe PMC140 |
| 2001 |
McGuire, J., Okamoto, K., Whitelaw, M., Tanaka, H., & Poellinger, L. (2001). Definition of a dioxin receptor mutant that is a constitutive activator of transcription - Delineation of overlapping repression and ligand binding functions within the PAS domain. Journal of Biological Chemistry, 276(45), 41841-41849.
DOI Scopus77 Europe PMC53 |
| 2000 |
Lando, D., Pongratz, I., Poellinger, L., & Whitelaw, M. (2000). A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1a and the HIF-like factor. Journal of Biological Chemistry, 275(7), 4618-4627.
DOI Scopus137 Europe PMC88 |
| 1999 |
Lees, M., & Whitelaw, M. (1999). Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt. Molecular and Cellular Biology, 19(8), 5811-5822.
DOI Scopus81 Europe PMC45 |
| 1999 |
Roberts, B., & Whitelaw, M. (1999). Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway. Journal of Biological Chemistry, 274(51), 36351-36356.
DOI Scopus98 Europe PMC60 |
| 1998 |
Dogra, S., Whitelaw, M., & May, B. (1998). Transcriptional activation of Cytochrome P450 genes by different classes of chemical inducers. Clinical and Experimental Pharmacology and Physiology, 25(1), 1-9.
DOI Scopus66 Europe PMC29 |
| 1998 |
Pongratz, I., Antonsson, C., Whitelaw, M., & Poellinger, L. (1998). Role of the PAS domain in regulation of demerization & DNA binding specificity of the dioxin receptor. Molecular and Cellular Biology, 18(7), 4079-4088.
DOI Scopus84 Europe PMC51 |
| 1996 |
McGuire, J., Coumailleau, P., Whitelaw, M. L., Gustafsson, J. -Å., & Poellinger, L. (1996). The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:. Journal of Biological Chemistry, 270(52), 31353-31357.
DOI Scopus52 Europe PMC30 |
| 1996 |
Gradin, K., McGuire, J., Wenger, R., Kvietikova, I., Whitelaw, M., Toftgard, R., . . . Poellinger, L. (1996). Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Molecular and Cellular Biology, 16(10), 5221-5231.
DOI Scopus355 Europe PMC210 |
| 1995 |
Coumailleau, P., Poellinger, L., Gustafsson, J., & Whitelaw, M. (1995). Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. Journal of Biological Chemistry, 270(42), 25291-25300.
DOI Scopus134 Europe PMC76 |
| 1995 |
Lindebro, M., Poellinger, L., & Whitelaw, M. (1995). Protein-protein interaction via PAS domains: Role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO Journal, 14(14), 3528-3539.
DOI Scopus156 Europe PMC99 |
| 1995 |
Antonsson, C., Arulampalam, V., Whitelaw, M., Pettersson, S., & Poellinger, L. (1995). Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif. Journal of Biological Chemistry, 270(23), 13968-13972.
DOI Scopus86 Europe PMC44 |
| 1995 |
Antonsson, C., Whitelaw, M., McGuire, J., Gustafsson, J., & Poellinger, L. (1995). Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains. Molecular and Cellular Biology, 15(2), 756-765.
DOI Scopus88 Europe PMC48 |
| 1995 |
Whitelaw, M., Mcguire, J., Picard, D., Gustafsson, J., & Poellinger, L. (1995). Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proceedings of the National Academy of Sciences of the United States of America, 92(10), 4437-4441.
DOI Scopus105 Europe PMC53 |
| 1994 |
Mason, G., Witte, A., Whitelaw, M., Antonsson, C., McGuire, J., Wilhelmsson, A., . . . Gustafsson, J. (1994). Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function. Journal of Biological Chemistry, 269(6), 4438-4449.
Scopus47 Europe PMC32 |
| 1994 |
Gradin, K., Whitelaw, M., Toftgård, R., Poellinger, L., & Berghard, A. (1994). A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. Journal of Biological Chemistry, 269(38), 23800-23807.
Scopus52 Europe PMC27 |
| 1994 |
Whitelaw, M., Gustafsson, J., & Poellinger, L. (1994). Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation. Molecular and Cellular Biology, 14(12), 8343-8355.
DOI Scopus139 Europe PMC80 |
| 1994 |
McGuire, J., Whitelaw, M., Pongratz, I., Gustafsson, J., & Poellinger, L. (1994). A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor. Molecular and Cellular Biology, 14(4), 2438-2446.
DOI Scopus105 Europe PMC63 |
| 1994 |
Wilhelmsson, A., Whitelaw, M., Gustafsson, J., & Poellinger, L. (1994). Agonistic and antagonistic effects of α-naphthoflavone on dioxin receptor function. Role of the basic region helix-loop-helix dioxin receptor partner factor Arnt. Journal of Biological Chemistry, 269(29), 19028-19033.
Scopus71 Europe PMC43 |
| 1993 |
Berghard, A., Gradin, K., Pongratz, I., Whitelaw, M., & Poellinger, L. (1993). Cross-Coupling of Signal Transduction Pathways: The Dioxin Receptor Mediates Induction of Cytochrome P-450IA1 Expression via a Protein Kinase C-Dependent Mechanism. Molecular and Cellular Biology, 13(1), 677-689.
DOI Scopus147 Europe PMC77 |
| 1993 |
Whitelaw, M., Pongratz, I., Wilhelmsson, A., Gustafsson, J., & Poellinger, L. (1993). Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Molecular and Cellular Biology, 13(4), 2504-2514.
DOI Scopus170 Europe PMC92 |
| 1993 |
Whitelaw, M., Gottlicher, M., Gustafsson, J., & Poellinger, L. (1993). Definition of a novel ligand binding domain of a nuclear bHLH receptor: Co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor. EMBO Journal, 12(11), 4169-4179.
DOI Scopus114 Europe PMC66 |
| 1991 |
Whitelaw, M., Hutchison, K., & Perdew, G. (1991). A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60(v-src)hsp90 in cells transformed by the Rous sarcoma virus. Journal of Biological Chemistry, 266(25), 16436-16440.
Scopus78 Europe PMC38 |
| 1991 |
Whitelaw, M., Chung, H., & Daniel, J. (1991). Synthesis and sensory evaluation of ring-substituted dihydrochalcone sweeteners. 2. Analogues of 3′-carboxyhesperetin dihydrochalcone, a high-potency dihydrochalcone sweetener. Journal of Agricultural and Food Chemistry, 39(4), 663-667.
DOI Scopus19 |
| 1991 |
Whitelaw, M., & Daniel, J. (1991). Synthesis and Sensory Evaluation of Ring-Substituted Dihydrochalcone Sweeteners. Journal of Agricultural and Food Chemistry, 39(1), 44-51.
DOI Scopus13 |
| 1991 |
Perdew, G., & Whitelaw, M. (1991). Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with M(r) of 63,000, 56,000, and 50,000. Journal of Biological Chemistry, 266(11), 6708-6713.
Scopus135 Europe PMC66 |
| 1991 |
Wood, K., Bonham, C., Whitelaw, M., & Daniel, J. (1991). Mass spectra of substituted dihydrocbalcones. Organic Mass Spectrometry, 26(1), 45-46.
DOI Scopus2 |
| 1988 |
WHITELAW, M., & WEAVER, C. (1988). Maillard Browning Effects on In Vitro Availability of Zinc. Journal of Food Science, 53(5), 1508-1510.
DOI Scopus17 |
