Murray Whitelaw

Research Interests

Biochemistry & Molecular Biology Biochemistry and Cell Biology Gene Expression Neurogenetics Structural Biology

Prof Murray Whitelaw

School of Biological Sciences

College of Science

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Our laboratory studies how mammalian cells adapt to environmental and physiological perturbations. We are investigating the basic-Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) family of transcription factors, a set of proteins that function as intracellular stress sensors for hypoxia, toxin infiltration, infection and neuron hyperexcitation. Understanding the biochemical mechanisms which trigger activition of bHLH/PAS proteins, and subsequently how they regulate specific sets of target genes to facilitate cell survival and a return to homeostasis, is a central aim of our research.  Our ambition is to advance knowledge of how various bHLH/PAS proteins protect against (or when misregulated, exacerbate) pathologies such as cancer, ischemia, metabolic diseases and neuropsychiatric disorders. A better molecular understanding of these disease states will underpin new therapeutic approaches and drug design strategies. 

Date Position Institution name
1996 - ongoing Teaching and Research Academic, levels B through E University of Adelaide
1991 - 1995 Guestforskare (guest reseacher/postdoctoral fellow) Karolinska Institute
1981 - 1984 Synthetic Organic Chemist ICI Australia

Date Institution name Country Title
1984 - 1989 Purdue University United States PhD
1977 - 1980 University of Melbourne Australia BSc(Hons)

Date Title Institution Country
1990 - 1990 Postdoctoral Fellow Purdue University United States

Year Citation
2025 Allen, T. P., Roennfeldt, A. E., Reckdharajkumar, M., Sullivan, A. E., Liu, M., Quinn, R. J., . . . Bersten, D. C. (2025). dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening. Nature Communications, 16(1), 3298-1-3298-18.
DOI
2023 Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15.
DOI Scopus4 WoS4 Europe PMC3
2023 Roennfeldt, A. E., Allen, T. P., Trowbridge, B. N., Beard, M. R., Whitelaw, M. L., Russell, D. L., . . . Peet, D. J. (2023). NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways. Biomolecules, 13(10), 1545-1-1545-16.
DOI
2022 Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity.
DOI Europe PMC1
2022 Button, E. L., Rossi, J. J., McDougal, D. P., Bruning, J. B., Peet, D., Bersten, D., . . . Whitelaw, M. (2022). Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.. The Biochemical journal, 479(13), 1441-1454.
DOI Scopus5 WoS3 Europe PMC3
2021 Rossi, J. J., Rosenfeld, J. A., Chan, K. M., Streff, H., Nankivell, V., Peet, D. J., . . . Bersten, D. C. (2021). Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders.. Sci Rep, 11(1), 1-11.
DOI Scopus12 WoS10 Europe PMC8
2020 Coban, M. A., Blackburn, P. R., Whitelaw, M. L., Haelst, M. M. V., Atwal, P. S., & Caulfield, T. R. (2020). Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain.. Biomolecules, 10(9), 17 pages.
DOI Scopus6 WoS5 Europe PMC5
2020 Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., . . . Atwal, P. S. (2020). Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.. J Clin Endocrinol Metab, 105(1), 355-361.
DOI Scopus14 WoS11 Europe PMC9
2017 Button, E., Bersten, D., & Whitelaw, M. (2017). HIF has Biff - Crosstalk between HIF1a and the family of bHLH/PAS proteins. Experimental Cell Research, 356(2), 141-145.
DOI Scopus26 WoS24 Europe PMC26
2017 Moir, L., Bochukova, E. G., Dumbell, R., Banks, G., Bains, R. S., Nolan, P. M., . . . Cox, R. D. (2017). Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6(11), 1419-1428.
DOI Scopus18 WoS14 Europe PMC14
2016 Sullivan, A., Peet, D., & Whitelaw, M. (2016). MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS Journal, 283(18), 3488-3502.
DOI Scopus10 WoS10 Europe PMC10
2015 Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M., . . . Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128(2), 225-231.
DOI Scopus38 WoS38 Europe PMC30
2015 Bersten, D., Sullivan, A., Li, D., Bhakti, V., Bent, S., & Whitelaw, M. (2015). Inducible and reversible lentiviral and recombination mediated cassette exchange (RMCE) systems for controlling gene expression. PLoS One, 10(3), e0116373-1-e0116373-20.
DOI Scopus6 WoS6 Europe PMC5
2014 Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
DOI Scopus9 WoS8 Europe PMC10
2014 Bersten, D., Bruning, J., Peet, D., & Whitelaw, M. (2014). Human variants in the Neuronal Basic Helix-Loop-Helix/ Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One, 9(1), e85768-1-e85768-11.
DOI Scopus22 WoS21 Europe PMC22
2014 Montagne, L., Raimondo, A., Delobel, B., Duban-Bedu, B., Noblet, F., Dechaume, A., . . . Bonnefond, A. (2014). Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay. Obesity, 22(12), 2621-2624.
DOI Scopus23 WoS16 Europe PMC10
2014 Bersten, D., Wright, J., McCarthy, P., & Whitelaw, M. (2014). Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochimica et Biophysica Acta, 1839(1), 13-24.
DOI Scopus37 WoS36 Europe PMC34
2013 Bersten, D., Sullivan, A., Peet, D., & Whitelaw, M. (2013). BHLH-PAS proteins in cancer. Nature Reviews. Cancer, 13(12), 827-841.
DOI Scopus219 WoS207 Europe PMC205
2013 Hao, N., & Whitelaw, M. (2013). The emerging roles of AhR in physiology and immunity. Biochemical Pharmacology, 86(5), 561-570.
DOI Scopus182 WoS173 Europe PMC162
2013 Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D., . . . Froguel, P. (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. Journal of Clinical Investigation, 123(7), 3037-3041.
DOI Scopus119 WoS105 Europe PMC98
2013 Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
DOI Scopus140 WoS115 Europe PMC115
2013 Hao, N., Bhakti, V., Peet, D., & Whitelaw, M. (2013). Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Research, 41(11), 5626-5638.
DOI Scopus30 WoS27 Europe PMC28
2013 Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., . . . Farooqi, I. S. (2013). Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016). Journal of Clinical Investigation, 123(8), 3635.
DOI Scopus1
2012 Hao, N., Lee, K., Furness, S., Bosdotter, C., Poellinger, L., & Whitelaw, M. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82(6), 1082-1093.
DOI Scopus26 WoS25 Europe PMC23
2011 Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B., & Chapman-Smith, A. (2011). Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Research, 39(9), 3695-3709.
DOI Scopus36 WoS32 Europe PMC33
2011 Cook, A., Vitale, A., Ravishankar, S., Matigian, N., Sutherland, G., Shan, J., . . . Wood, S. (2011). NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's Disease. PLoS One, 6(7), e21907-1-e21907-14.
DOI Scopus82 WoS79 Europe PMC67
2010 Whelan, F., Hao, N., Furness, S., Whitelaw, M., & Chapman-Smith, A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77(6), 1037-1046.
DOI Scopus21 WoS18 Europe PMC19
2009 Farrall, A., & Whitelaw, M. (2009). The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene, 28(41), 3671-3680.
DOI Scopus41 WoS40 Europe PMC37
2009 Dave, K., Whelan, F., Bindloss, C., Furness, S., Chapman-Smith, A., Whitelaw, M., & Gorman, J. (2009). Sulfonation and Phosphorylation of Regions of the Dioxin Receptor Susceptible to Methionine Modifications. Molecular and Cellular Proteomics, 8(4), 706-719.
DOI Scopus12 WoS10 Europe PMC8
2008 Woods, S., Farrall, A., Procko, C., & Whitelaw, M. (2008). The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence. Nucleic Acids Research, 36(11), 3716-3727.
DOI Scopus17 WoS15 Europe PMC12
2008 Zheng, X., Karttunen, S., Dias, J., Zheng, X., Gradin, K., Wallis, T., . . . Poellinger, L. (2008). Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3368-3373.
DOI Scopus222 WoS222 Europe PMC202
2007 Dave, K., Hamilton, B., Wallis, T., Furness, S., Whitelaw, M., & Gorman, J. (2007). Identification of N,Nε-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268(2-3), 168-180.
DOI Scopus10
2007 Furness, S., Lees, M., & Whitelaw, M. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581(19Sp. Iss.), 3616-3625.
DOI Scopus77 Europe PMC64
2006 Bracken, C., Fedele, A., Karttunen, S., Balrak, W., Lisy, K., Whitelaw, M., & Peet, D. (2006). Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment. Journal of Biological Chemistry, 281(32), 22575-22585.
DOI Scopus191 WoS186 Europe PMC171
2006 Chapman-Smith, A., & Whitelaw, M. (2006). Novel DNA binding by a basic helix-loop-helix protein - The role of the dioxin receptor PAS domain. Journal of Biological Chemistry, 281(18), 12535-12545.
DOI Scopus29 WoS28 Europe PMC26
2005 Kewley, R., & Whitelaw, M. (2005). Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator. Biochemical and Biophysical Research Communications, 338(1), 660-667.
DOI Scopus9 Europe PMC9
2005 Bracken, C., Whitelaw, M., & Peet, D. (2005). Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator. Journal of Biological Chemistry, 280(14), 14240-14251.
DOI Scopus62 WoS59 Europe PMC55
2004 Peet, D., Lando, D., Whelan, D., Whitelaw, M., & Gorman, J. (2004). Oxygen-dependent asparagine hydroxylation. Methods in Enzymology, 381, 467-487.
DOI Scopus22 WoS18 Europe PMC11
2004 Kewley, R., Whitelaw, M., & Chapman-Smith, A. (2004). The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. International Journal of Biochemistry & Cell Biology, 36(2), 189-204.
DOI Scopus512 WoS488 Europe PMC431
2004 Karttunen, S., Stojkoski, C., Kewley, R., Booker, G., Whitelaw, M., & Peet, D. (2004). Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. Biological Chemistry, 279(14), 14391-14397.
DOI Scopus71 WoS65 Europe PMC54
2004 Chapman-Smith, A., Lutwyche, J., & Whitelaw, M. (2004). Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. Journal of Biological Chemistry, 279(7), 5353-5362.
DOI Scopus71 WoS67 Europe PMC64
2004 Kaufman, B., Scharf, O., Arbeit, J., Ashcroft, M., Brown, J., Bruick, R., . . . Ivy, S. (2004). Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research, 64(9), 3350-3356.
DOI Scopus34 Europe PMC23
2003 Bracken, C., Whitelaw, M., & Peet, D. (2003). The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cellular and Molecular Life Sciences, 60(7), 1376-1393.
DOI Scopus224 WoS206 Europe PMC186
2003 Lees, M., Peet, D., & Whitelaw, M. (2003). Defining the role for XAP2 in stabilization of the dioxin receptor. Journal of Biological Chemistry, 278(38), 35878-35888.
DOI Scopus82 WoS68 Europe PMC58
2003 Lando, D., Gorman, J., Whitelaw, M., & Peet, D. (2003). Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. FEBS Journal, 270(5), 781-790.
DOI Scopus123 WoS105 Europe PMC87
2002 Fedele, A., Whitelaw, M., & Peet, D. (2002). Regulation of gene expression by the hypoxia-inducible factors. Molecular Interventions, 2(4), 229-243.
DOI Scopus76 Europe PMC57
2002 Lando, D., Peet, D., Pongratz, I., & Whitelaw, M. (2002). Mammalian two-hybrid assay showing redox control of HIF-like factor. Methods in Enzymology, 353, 3-10.
DOI Scopus3 WoS3 Europe PMC2
2002 Swanson, H., Whitelaw, M., Petrulis, J., & Perdew, G. (2002). Use of [¹²⁵I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. Journal of Biochemical and Molecular Toxicology, 16(6), 298-310.
DOI Scopus5 Europe PMC3
2002 Lees, M., & Whitelaw, M. (2002). Effect of ARA9 on dioxin receptor mediated transcription. Toxicology, 181-182, 143-146.
DOI Scopus9 Europe PMC7
2002 Lando, D., Peet, D., Gorman, J., Whelan, D., Whitelaw, M., & Bruick, R. (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes & Development, 16(12), 1466-1471.
DOI Scopus1345 WoS1277 Europe PMC1144
2002 Woods, S., & Whitelaw, M. (2002). Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element - Cross-talk between basic helix-loop-helix/Per-Arnt-Sim homology transcription factors. Journal of Biological Chemistry, 277(12), 10236-10243.
DOI Scopus63 WoS62 Europe PMC58
2002 Lando, D., Peet, D., Whelan, D., Gorman, J., & Whitelaw, M. (2002). Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science, 295(5556), 858-861.
DOI Scopus1368 WoS1278 Europe PMC1100
2002 Andersson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M., Pettersson, S., . . . Poellinger, L. (2002). A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 9990-9995.
DOI Scopus282 Europe PMC228
2001 McGuire, J., Okamoto, K., Whitelaw, M., Tanaka, H., & Poellinger, L. (2001). Definition of a dioxin receptor mutant that is a constitutive activator of transcription - Delineation of overlapping repression and ligand binding functions within the PAS domain. Journal of Biological Chemistry, 276(45), 41841-41849.
DOI Scopus90 Europe PMC80
2000 Lando, D., Pongratz, I., Poellinger, L., & Whitelaw, M. (2000). A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1a and the HIF-like factor. Journal of Biological Chemistry, 275(7), 4618-4627.
DOI Scopus155 Europe PMC122
1999 Lees, M., & Whitelaw, M. (1999). Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt. Molecular and Cellular Biology, 19(8), 5811-5822.
DOI Scopus87 Europe PMC68
1999 Roberts, B., & Whitelaw, M. (1999). Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway. Journal of Biological Chemistry, 274(51), 36351-36356.
DOI Scopus111 Europe PMC92
1998 Dogra, S., Whitelaw, M., & May, B. (1998). Transcriptional activation of Cytochrome P450 genes by different classes of chemical inducers. Clinical and Experimental Pharmacology and Physiology, 25(1), 1-9.
DOI Scopus71 Europe PMC42
1998 Pongratz, I., Antonsson, C., Whitelaw, M., & Poellinger, L. (1998). Role of the PAS domain in regulation of demerization & DNA binding specificity of the dioxin receptor. Molecular and Cellular Biology, 18(7), 4079-4088.
DOI Scopus99 Europe PMC84
1996 McGuire, J., Coumailleau, P., Whitelaw, M. L., Gustafsson, J. -Å., & Poellinger, L. (1996). The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:. Journal of Biological Chemistry, 270(52), 31353-31357.
DOI Scopus54 Europe PMC45
1996 Gradin, K., McGuire, J., Wenger, R., Kvietikova, I., Whitelaw, M., Toftgard, R., . . . Poellinger, L. (1996). Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Molecular and Cellular Biology, 16(10), 5221-5231.
DOI Scopus401 Europe PMC322
1995 Coumailleau, P., Poellinger, L., Gustafsson, J. A., & Whitelaw, M. L. (1995). Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. Journal of Biological Chemistry, 270(42), 25291-25300.
DOI Scopus147 Europe PMC109
1995 Lindebro, M. C., Poellinger, L., & Whitelaw, M. L. (1995). Protein-protein interaction via PAS domains: Role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO Journal, 14(14), 3528-3539.
DOI Scopus168 Europe PMC141
1995 Antonsson, C., Arulampalam, V., Whitelaw, M. L., Pettersson, S., & Poellinger, L. (1995). Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif. Journal of Biological Chemistry, 270(23), 13968-13972.
DOI Scopus91 Europe PMC67
1995 Antonsson, C., Whitelaw, M. L., Mcguire, J., Gustafsson, J. A., & Poellinger, L. (1995). Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains. Molecular and Cellular Biology, 15(2), 756-765.
DOI Scopus104 Europe PMC77
1995 Whitelaw, M. L., Mcguire, J., Picard, D., Gustafsson, J. A., & Poellinger, L. (1995). Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proceedings of the National Academy of Sciences of the United States of America, 92(10), 4437-4441.
DOI Scopus116 Europe PMC84
1994 Mason, G. G. F., Witte, A. M., Whitelaw, M. L., Antonsson, C., McGuire, J., Wilhelmsson, A., . . . Gustafsson, J. A. (1994). Purification of the DNA binding form of dioxin receptor: Role of the Arnt cofactor in regulation of dixon receptor function. Journal of Biological Chemistry, 269(6), 4438-4449.
DOI Scopus56 Europe PMC49
1994 Gradin, K., Whitelaw, M. L., Toftgård, R., Poellinger, L., & Berghard, A. (1994). A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. Journal of Biological Chemistry, 269(38), 23800-23807.
DOI Scopus58 Europe PMC42
1994 Whitelaw, M. L., Gustafsson, J. A., & Poellinger, L. (1994). Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation. Molecular and Cellular Biology, 14(12), 8343-8355.
DOI Scopus153 Europe PMC102
1994 McGuire, J., Whitelaw, M. L., Pongratz, I., Gustafsson, J. A., & Poellinger, L. (1994). A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor. Molecular and Cellular Biology, 14(4), 2438-2446.
DOI Scopus126 Europe PMC88
1994 Wilhelmsson, A., Whitelaw, M. L., Gustafsson, J. A., & Poellinger, L. (1994). Agonistic and antagonistic effects of α-naphthoflavone on dioxin receptor function: Role of the basic region helix-loop-helix dioxin receptor partner factor arnt. Journal of Biological Chemistry, 269(29), 19028-19033.
DOI Scopus72 Europe PMC54
1993 Berghard, A., Gradin, K., Pongratz, I., Whitelaw, M., & Poellinger, L. (1993). Cross-Coupling of Signal Transduction Pathways: The Dioxin Receptor Mediates Induction of Cytochrome P-450IA1 Expression via a Protein Kinase C-Dependent Mechanism. Molecular and Cellular Biology, 13(1), 677-689.
DOI Scopus162 Europe PMC94
1993 Whitelaw, M., Pongratz, I., Wilhelmsson, A., Gustafsson, J. A., & Poellinger, L. (1993). Ligand-dependent recruitment of the arnt coregulator determines DNA recognition by the dioxin receptor. Molecular and Cellular Biology, 13(4), 2504-2514.
DOI Scopus207 Europe PMC117
1993 Whitelaw, M. L., Göttlicher, M., Gustafsson, J. A., & Poellinger, L. (1993). Definition of a novel ligand binding domain of a nuclear bHLH receptor: Co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor. EMBO Journal, 12(11), 4169-4179.
DOI Scopus139 Europe PMC116
1991 Whitelaw, M. L., Hutchison, K., & Perdew, G. H. (1991). A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the rous sarcoma virus. Journal of Biological Chemistry, 266(25), 16436-16440.
DOI Scopus93 Europe PMC71
1991 Whitelaw, M. L., Chung, H. J., & Daniel, J. R. (1991). Synthesis and sensory evaluation of ring-substituted dihydrochalcone sweeteners. 2. Analogues of 3′-carboxyhesperetin dihydrochalcone, a high-potency dihydrochalcone sweetener. Journal of Agricultural and Food Chemistry, 39(4), 663-667.
DOI Scopus22
1991 Whitelaw, M. L., & Daniel, J. R. (1991). Synthesis and Sensory Evaluation of Ring-Substituted Dihydrochalcone Sweeteners. Journal of Agricultural and Food Chemistry, 39(1), 44-51.
DOI Scopus14
1991 Perdew, G. H., & Whitelaw, M. L. (1991). Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000. Journal of Biological Chemistry, 266(11), 6708-6713.
DOI Scopus171 Europe PMC115
1991 Wood, K. V., Bonham, C. C., Whitelaw, M. L., & Daniel, J. R. (1991). Mass spectra of substituted dihydrocbalcones. Organic Mass Spectrometry, 26(1), 45-46.
DOI Scopus2
1988 WHITELAW, M. L., & WEAVER, C. M. (1988). Maillard Browning Effects on In Vitro Availability of Zinc. Journal of Food Science, 53(5), 1508-1510.
DOI Scopus18

Year Citation
2008 Gorman, J. J., Dave, K. A., Whelan, F., Hamilton, B. R., Wallis, T. P., Headlam, M. J., . . . Whitelaw, M. L. (2008). Comparison of Stable-Isotope Labelling Strategies for Quantification of Phosphosite Occupancy and Differentiation Between Phosphorylation and Sulfonation of the Murine Dioxin Receptor. In Journal of Proteomics & Bioinformatics Vol. S2 (pp. 067-068). OMICS Publishing Group.
DOI

Year Citation
2012 Hao, N., Shearwin, K., Dodd, I., Whitelaw, M., & Chapman-Smith, A. (2012). Reverse Bacterial Two Hybrid: A New Tool for Studying Dimeric Protein Interactions. Poster session presented at the meeting of ASBMB ComBio conference. Adelaide.
2009 Hao, N., Shearwin., Dodd, I., Whitelaw, M., & Chapman-Smith, A. (2009). Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions. Poster session presented at the meeting of Network in Genes and Environment in Development (NGED) Forum. Palm Cove, Queensland.
2009 Hao, N., Shearwin, K., Dodd, I., Whitelaw, M., & Chapman-smith, A. (2009). A novel Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions and screening for potential therapeutics. Poster session presented at the meeting of Australian Society for Medical Research (ASMR) SA Scientific Meeting. Adelaide.

Year Citation
2012 Hao, N. (2012). Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt. (PhD Thesis, The University of Adelaide).
2007 Hao, N. (2007). Searching for HIF-1α/Arnt PAS Domain Interacting Proteins. (The University of Adelaide).

Year Citation
- Roennfeldt, A., Allen, T., Trowbridge, B., Beard, M., Whitelaw, M., Russell, D., . . . Peet, D. (n.d.). Graph Pad prism files of all data published in Roennfeldt et al. (2023). Data points for each experiment represents the mean of an individual replicate (and thus each experiment was completed in triplicate with the mean +/- standard deviation graphed)..
DOI

Year Citation
2023 Allen, T., Roennfeldt, A., Reckdharajkumar, M., Liu, M., Quinn, R., Russell, D., . . . Bersten, D. (2023). dFLASH; dual FLuorescent transcription factor Activity Sensor for Histone integrated live-cell reporting and high-content screening.
DOI

National Health and Medical Research Council

Date Role Research Topic Program Degree Type Student Load Student Name
2017 Principal Supervisor bHLH PAS and HD protein interactions in neuronal development and pathology Doctor of Philosophy Doctorate Full Time Mr Joseph James Rossi

Date Role Research Topic Program Degree Type Student Load Student Name
2019 - 2024 Principal Supervisor Development and application of dual fluorescent reporting systems for HIF-1 alpha and other transcription factor pathways Doctor of Philosophy Doctorate Full Time Mr Timothy Patrick Allen
2017 - 2021 Co-Supervisor Understanding PPARg-Ligand Interactions to Treat Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Miss Rebecca Louise Frkic
2017 - 2022 Co-Supervisor Molecular Drivers of Aerobic Glycolysis in the Mammalian Retina Doctor of Philosophy Doctorate Full Time Mr Cameron David Haydinger
2015 - 2021 Principal Supervisor Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2 Doctor of Philosophy Doctorate Full Time Miss Alexis Georgia Gerassimou
2014 - 2019 Co-Supervisor Identification and Validation of SOXB1 Bound Developmental Enhancers Doctor of Philosophy Doctorate Full Time Ella Paulina Thomson
2014 - 2020 Co-Supervisor Investigating the Warburg effect and the role of pyruvate kinase M2 in retinal Müller glial cells Doctor of Philosophy Doctorate Full Time Miss Thaksaon Kittipassorn
2014 - 2023 Principal Supervisor Function and Mechanism of The Single-Minded 2 Gene Doctor of Philosophy Doctorate Full Time Emily Lyn Button
2013 - 2018 Co-Supervisor Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Jacqueline-Alba Fabrizio
2012 - 2017 Co-Supervisor A Role for Bivalent Genes in Epithelial to Mesenchymal Transition Doctor of Philosophy Doctorate Part Time Mr Francisco Sadras
2011 - 2017 Co-Supervisor Development and Applications of CRISPR/Cas9 Genome Editing Technology Doctor of Philosophy Doctorate Full Time Dr Fatwa Adikusuma
2011 - 2018 Co-Supervisor Investigating the Role of HIF-1 and HIF-2 Transcription Factors in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Natalia Magdalena Martin
2009 - 2016 Principal Supervisor Function and Regulation of Single-minded 1 and Single-minded 2 Transcription Factors in Disease Doctor of Philosophy Doctorate Full Time Ms Adrienne Sullivan
2009 - 2020 Co-Supervisor Deciphering the Transcriptional Mechanisms and Function of SOX3 in the Developing Embryonic Mouse Brain and Postnatal Testes Doctor of Philosophy Doctorate Full Time Mr Dale Christopher McAninch
2008 - 2012 Principal Supervisor Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt Doctor of Philosophy Doctorate Full Time Dr Nan Hao
2007 - 2012 Co-Supervisor Characterising Ankyrin Repeat Proteins as Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Sarah Wilkins
2006 - 2011 Principal Supervisor Identification of Downstream Target Genes and Analysis of Obesity-Related Variants of the bHLH/PAS Transcription Factor Single-Minded 1 Doctor of Philosophy Doctorate Full Time Miss Anne Raimondo
2006 - 2012 Co-Supervisor Expression and Function of Npas4 During Early Development Doctor of Philosophy Doctorate Full Time Dr Tom Klaric
2006 - 2012 Co-Supervisor Regulation of the Rgs4 Gene by the Hypoxia Inducible Factors Doctor of Philosophy Doctorate Full Time Mr Sam Olechnowicz
2006 - 2014 Principal Supervisor Regulation of Expression and Activity of the bHLH-PAS Transcription Factor NPAS4 Doctor of Philosophy Doctorate Full Time Dr David Bersten
2005 - 2006 Principal Supervisor The Role of Glycogen Synthase Kinase-3 in Early Embryonic Stem Cell Differentiation Master of Science Master Full Time Mr Cameron McLean
2005 - 2011 Co-Supervisor Investigation into The Molecular Function of The Neuronal Hu RNA Binding Protein, HuCsv1 Doctor of Philosophy Doctorate Full Time Mr Peter James McCarthy
2005 - 2011 Co-Supervisor Investigating Potential Post-Translational Modification of Factor-Inhibiting HIF (FIH-1) Doctor of Philosophy Doctorate Full Time Ms Karolina Lisy
2005 - 2016 Co-Supervisor Identification and Characterisation of Novel Substrates and Binding Partners of the Asparaginyl Hydroxylase, FIH Doctor of Philosophy Doctorate Part Time Miss Rachel Jane Hampton-Smith
2004 - 2008 Co-Supervisor Substrate Specificity of Factor Inhibiting HIF-1 (FIH-1) Doctor of Philosophy Doctorate Full Time Dr Sarah Karttunen
2004 - 2009 Principal Supervisor Gene Regulatory and Pro-Tumourigenic Mechanisms of the bHLH-PAS Transcription Factor SIM2s Doctor of Philosophy Doctorate Full Time Ms Alexandra Farrall
2004 - 2010 Co-Supervisor The Deubiquitylating Enzyme USP9X Promotes the Polarity and Self-Renewal of Neural Progenitor Cells Doctor of Philosophy Doctorate Full Time Dr Lachlan Jolly
2003 - 2005 Principal Supervisor Differential Function and Regulation of the Hypoxia Inducible Factors in the Rat Pheochromocytoma Cell Line Pc12 Doctor of Philosophy Doctorate Full Time Mr Anthony Olind Fedele
2003 - 2009 Principal Supervisor The Aryl Hydrocarbon Receptor: Structural Analysis and Activation Mechanisms Doctor of Philosophy Doctorate Full Time Dr Fiona Whelan
2002 - 2004 Co-Supervisor Mechanisms of embryonic stem cell division and differentiation Doctor of Philosophy Doctorate Full Time Dr Josephine Amelia Wright
2001 - 2005 Principal Supervisor Characterising the Differential Regulation of Hypoxia-Inducible Factor 1a and 2a Doctor of Philosophy Doctorate Full Time APrf Cameron Bracken
1999 - 2004 Principal Supervisor NOVEL MECHANISMS FOR ACTIVATION OF THE DIOXIN (ARYL-HYDROCARBON) RECEPTOR Doctor of Philosophy Doctorate Full Time Mr Sebastian Furness
1999 - 2004 Principal Supervisor CROSS-TALK BETWEEN SIM & OTHER bHLH/PAS FACTORS & THE SEARCH FOR SIM2 TARGET GENES Doctor of Philosophy Doctorate Full Time APrf Susan Lesley Woods
1998 - 2002 Principal Supervisor CHARACTERISING MECHANISMS OF REGULATION OF HYPOXIA-INDUCIBLE FACTORS Doctor of Philosophy Doctorate Full Time Dr David Lando
1998 - 2003 Principal Supervisor INVESTIGATING THE ROLE OF ARNT ISOFORMS AS bHLH/PAS TRANSCRIPTIONAL REGULATORS Doctor of Philosophy Doctorate Full Time Miss Robyn Kewley
1997 - 2003 Principal Supervisor Characterising the mechanism of Activation of the bHLH/PAS Dioxin Receptor Doctor of Philosophy Doctorate Full Time Mr Michael Lees

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