Murray Whitelaw

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

My Research
Career
Publications
Grants and Funding
Supervision
Contact

Our laboratory studies how mammalian cells adapt to environmental and physiological perturbations. We are investigating the basic-Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) family of transcription factors, a set of proteins that function as intracellular stress sensors for hypoxia, toxin infiltration, infection and neuron hyperexcitation. Understanding the biochemical mechanisms which trigger activition of bHLH/PAS proteins, and subsequently how they regulate specific sets of target genes to facilitate cell survival and a return to homeostasis, is a central aim of our research. Our ambition is to advance knowledge of how various bHLH/PAS proteins protect against (or when misregulated, exacerbate) pathologies such as cancer, ischemia, metabolic diseases and neuropsychiatric disorders. A better molecular understanding of these disease states will underpin new therapeutic approaches and drug design strategies.

Appointments

Date	Position	Institution name
1996 - ongoing	Teaching and Research Academic, levels B through E	University of Adelaide
1991 - 1995	Guestforskare (guest reseacher/postdoctoral fellow)	Karolinska Institute
1981 - 1984	Synthetic Organic Chemist	ICI Australia

Education

Date Institution name Country Title

1984 - 1989 Purdue University United States PhD

1977 - 1980 University of Melbourne Australia BSc(Hons)
Postgraduate Training

Date Title Institution Country

1990 - 1990 Postdoctoral Fellow Purdue University United States
Research Interests

Biochemistry & Molecular Biology Biochemistry and Cell Biology Gene Expression Neurogenetics Structural Biology

Date	Institution name	Country	Title
1984 - 1989	Purdue University	United States	PhD
1977 - 1980	University of Melbourne	Australia	BSc(Hons)

Date	Title	Institution	Country
1990 - 1990	Postdoctoral Fellow	Purdue University	United States

Journals

Year	Citation
2023	Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15. DOI Scopus3 WoS2 Europe PMC2
2023	Roennfeldt, A. E., Allen, T. P., Trowbridge, B. N., Beard, M. R., Whitelaw, M. L., Russell, D. L., . . . Peet, D. J. (2023). NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways. Biomolecules, 13(10), 1545-1-1545-16. DOI
2022	Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity. DOI
2022	Button, E. L., Rossi, J. J., McDougal, D. P., Bruning, J. B., Peet, D., Bersten, D., . . . Whitelaw, M. (2022). Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.. The Biochemical journal, 479(13), 1441-1454. DOI Scopus2 Europe PMC1
2021	Rossi, J. J., Rosenfeld, J. A., Chan, K. M., Streff, H., Nankivell, V., Peet, D. J., . . . Bersten, D. C. (2021). Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders.. Sci Rep, 11(1), 1-11. DOI Scopus10 WoS4 Europe PMC6
2020	Coban, M. A., Blackburn, P. R., Whitelaw, M. L., Haelst, M. M. V., Atwal, P. S., & Caulfield, T. R. (2020). Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain.. Biomolecules, 10(9), 17 pages. DOI Scopus4 WoS3 Europe PMC3
2020	Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., . . . Atwal, P. S. (2020). Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.. J Clin Endocrinol Metab, 105(1), 355-361. DOI Scopus11 WoS6 Europe PMC6
2017	Button, E., Bersten, D., & Whitelaw, M. (2017). HIF has Biff - Crosstalk between HIF1a and the family of bHLH/PAS proteins. Experimental Cell Research, 356(2), 141-145. DOI Scopus24 WoS16 Europe PMC17
2017	Moir, L., Bochukova, E. G., Dumbell, R., Banks, G., Bains, R. S., Nolan, P. M., . . . Cox, R. D. (2017). Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6(11), 1419-1428. DOI Scopus15 WoS8 Europe PMC8
2016	Sullivan, A., Peet, D., & Whitelaw, M. (2016). MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS Journal, 283(18), 3488-3502. DOI Scopus10 WoS10 Europe PMC10
2015	Karttunen, S., Duffield, M., Scrimgeour, N., Squires, L., Lim, W., Dallas, M., . . . Peet, D. (2015). Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. Journal of Cell Science, 128(2), 225-231. DOI Scopus37 WoS33 Europe PMC29
2015	Bersten, D., Sullivan, A., Li, D., Bhakti, V., Bent, S., & Whitelaw, M. (2015). Inducible and reversible lentiviral and recombination mediated cassette exchange (RMCE) systems for controlling gene expression. PLoS One, 10(3), e0116373-1-e0116373-20. DOI Scopus5 WoS3 Europe PMC3
2014	Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412. DOI Scopus9 WoS8 Europe PMC8
2014	Bersten, D., Bruning, J., Peet, D., & Whitelaw, M. (2014). Human variants in the Neuronal Basic Helix-Loop-Helix/ Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One, 9(1), e85768-1-e85768-11. DOI Scopus20 WoS20 Europe PMC19
2014	Montagne, L., Raimondo, A., Delobel, B., Duban-Bedu, B., Noblet, F., Dechaume, A., . . . Bonnefond, A. (2014). Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay. Obesity, 22(12), 2621-2624. DOI Scopus23 WoS15 Europe PMC7
2014	Bersten, D., Wright, J., McCarthy, P., & Whitelaw, M. (2014). Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochimica et Biophysica Acta, 1839(1), 13-24. DOI Scopus31 WoS25 Europe PMC26
2013	Bersten, D., Sullivan, A., Peet, D., & Whitelaw, M. (2013). BHLH-PAS proteins in cancer. Nature Reviews. Cancer, 13(12), 827-841. DOI Scopus200 WoS159 Europe PMC157
2013	Hao, N., & Whitelaw, M. (2013). The emerging roles of AhR in physiology and immunity. Biochemical Pharmacology, 86(5), 561-570. DOI Scopus167 WoS145 Europe PMC111
2013	Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D., . . . Froguel, P. (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. Journal of Clinical Investigation, 123(7), 3037-3041. DOI Scopus103 WoS78 Europe PMC69
2013	Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050. DOI Scopus128 WoS98 Europe PMC89
2013	Hao, N., Bhakti, V., Peet, D., & Whitelaw, M. (2013). Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Research, 41(11), 5626-5638. DOI Scopus28 WoS24 Europe PMC26
2013	Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., . . . Farooqi, I. S. (2013). Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016). Journal of Clinical Investigation, 123(8), 3635. DOI Scopus1
2012	Hao, N., Lee, K., Furness, S., Bosdotter, C., Poellinger, L., & Whitelaw, M. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82(6), 1082-1093. DOI Scopus25 WoS21 Europe PMC19
2011	Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B., & Chapman-Smith, A. (2011). Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Research, 39(9), 3695-3709. DOI Scopus34 WoS28 Europe PMC29
2011	Cook, A., Vitale, A., Ravishankar, S., Matigian, N., Sutherland, G., Shan, J., . . . Wood, S. (2011). NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's Disease. PLoS One, 6(7), e21907-1-e21907-14. DOI Scopus80 WoS72 Europe PMC53
2010	Whelan, F., Hao, N., Furness, S., Whitelaw, M., & Chapman-Smith, A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77(6), 1037-1046. DOI Scopus21 WoS17 Europe PMC17
2009	Farrall, A., & Whitelaw, M. (2009). The HIF1α-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene, 28(41), 3671-3680. DOI Scopus40 WoS38 Europe PMC33
2009	Dave, K., Whelan, F., Bindloss, C., Furness, S., Chapman-Smith, A., Whitelaw, M., & Gorman, J. (2009). Sulfonation and Phosphorylation of Regions of the Dioxin Receptor Susceptible to Methionine Modifications. Molecular and Cellular Proteomics, 8(4), 706-719. DOI Scopus12 WoS10 Europe PMC5
2008	Woods, S., Farrall, A., Procko, C., & Whitelaw, M. (2008). The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence. Nucleic Acids Research, 36(11), 3716-3727. DOI Scopus16 WoS14 Europe PMC11
2008	Zheng, X., Karttunen, S., Dias, J., Zheng, X., Gradin, K., Wallis, T., . . . Poellinger, L. (2008). Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3368-3373. DOI Scopus216 WoS207 Europe PMC178
2007	Dave, K., Hamilton, B., Wallis, T., Furness, S., Whitelaw, M., & Gorman, J. (2007). Identification of N,Nε-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268(2-3), 168-180. DOI Scopus10
2007	Furness, S., Lees, M., & Whitelaw, M. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581(19Sp. Iss.), 3616-3625. DOI Scopus76 Europe PMC59
2006	Bracken, C., Fedele, A., Karttunen, S., Balrak, W., Lisy, K., Whitelaw, M., & Peet, D. (2006). Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment. Journal of Biological Chemistry, 281(32), 22575-22585. DOI Scopus184 WoS171 Europe PMC135
2006	Chapman-Smith, A., & Whitelaw, M. (2006). Novel DNA binding by a basic helix-loop-helix protein - The role of the dioxin receptor PAS domain. Journal of Biological Chemistry, 281(18), 12535-12545. DOI Scopus28 WoS26 Europe PMC21
2005	Kewley, R., & Whitelaw, M. (2005). Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator. Biochemical and Biophysical Research Communications, 338(1), 660-667. DOI Scopus9 Europe PMC8
2005	Bracken, C., Whitelaw, M., & Peet, D. (2005). Activity of hypoxia-inducible factor 2α is regulated by association with the NF-κB essential modulator. Journal of Biological Chemistry, 280(14), 14240-14251. DOI Scopus59 WoS58 Europe PMC48
2004	Peet, D., Lando, D., Whelan, D., Whitelaw, M., & Gorman, J. (2004). Oxygen-dependent asparagine hydroxylation. Methods in Enzymology, 381, 467-487. DOI Scopus22 WoS17 Europe PMC11
2004	Kewley, R., Whitelaw, M., & Chapman-Smith, A. (2004). The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. International Journal of Biochemistry & Cell Biology, 36(2), 189-204. DOI Scopus495 WoS442 Europe PMC357
2004	Karttunen, S., Stojkoski, C., Kewley, R., Booker, G., Whitelaw, M., & Peet, D. (2004). Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. Biological Chemistry, 279(14), 14391-14397. DOI Scopus70 WoS63 Europe PMC44
2004	Chapman-Smith, A., Lutwyche, J., & Whitelaw, M. (2004). Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. Journal of Biological Chemistry, 279(7), 5353-5362. DOI Scopus70 WoS63 Europe PMC53
2004	Kaufman, B., Scharf, O., Arbeit, J., Ashcroft, M., Brown, J., Bruick, R., . . . Ivy, S. (2004). Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research, 64(9), 3350-3356. DOI Scopus34 Europe PMC20
2003	Bracken, C., Whitelaw, M., & Peet, D. (2003). The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cellular and Molecular Life Sciences, 60(7), 1376-1393. DOI Scopus216 WoS195 Europe PMC152
2003	Lees, M., Peet, D., & Whitelaw, M. (2003). Defining the role for XAP2 in stabilization of the dioxin receptor. Journal of Biological Chemistry, 278(38), 35878-35888. DOI Scopus81 WoS66 Europe PMC50
2003	Lando, D., Gorman, J., Whitelaw, M., & Peet, D. (2003). Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. FEBS Journal, 270(5), 781-790. DOI Scopus122 WoS102 Europe PMC73
2002	Fedele, A., Whitelaw, M., & Peet, D. (2002). Regulation of gene expression by the hypoxia-inducible factors. Molecular Interventions, 2(4), 229-243. DOI Scopus76 Europe PMC52
2002	Lando, D., Peet, D., Pongratz, I., & Whitelaw, M. (2002). Mammalian two-hybrid assay showing redox control of HIF-like factor. Methods in Enzymology, 353, 3-10. DOI Scopus3 WoS3 Europe PMC2
2002	Swanson, H., Whitelaw, M., Petrulis, J., & Perdew, G. (2002). Use of [¹²⁵I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. Journal of Biochemical and Molecular Toxicology, 16(6), 298-310. DOI Scopus5 Europe PMC2
2002	Lees, M., & Whitelaw, M. (2002). Effect of ARA9 on dioxin receptor mediated transcription. Toxicology, 181-182, 143-146. DOI Scopus9 Europe PMC4
2002	Lando, D., Peet, D., Gorman, J., Whelan, D., Whitelaw, M., & Bruick, R. (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes & Development, 16(12), 1466-1471. DOI Scopus1310 WoS1201 Europe PMC929
2002	Woods, S., & Whitelaw, M. (2002). Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element - Cross-talk between basic helix-loop-helix/Per-Arnt-Sim homology transcription factors. Journal of Biological Chemistry, 277(12), 10236-10243. DOI Scopus63 WoS62 Europe PMC51
2002	Lando, D., Peet, D., Whelan, D., Gorman, J., & Whitelaw, M. (2002). Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science, 295(5556), 858-861. DOI Scopus1336 WoS1219 Europe PMC887
2002	Andersson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M., Pettersson, S., . . . Poellinger, L. (2002). A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 9990-9995. DOI Scopus274 Europe PMC181
2001	McGuire, J., Okamoto, K., Whitelaw, M., Tanaka, H., & Poellinger, L. (2001). Definition of a dioxin receptor mutant that is a constitutive activator of transcription - Delineation of overlapping repression and ligand binding functions within the PAS domain. Journal of Biological Chemistry, 276(45), 41841-41849. DOI Scopus88 Europe PMC63
2000	Lando, D., Pongratz, I., Poellinger, L., & Whitelaw, M. (2000). A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1a and the HIF-like factor. Journal of Biological Chemistry, 275(7), 4618-4627. DOI Scopus155 Europe PMC103
1999	Lees, M., & Whitelaw, M. (1999). Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt. Molecular and Cellular Biology, 19(8), 5811-5822. DOI Scopus88 Europe PMC55
1999	Roberts, B., & Whitelaw, M. (1999). Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway. Journal of Biological Chemistry, 274(51), 36351-36356. DOI Scopus111 Europe PMC74
1998	Dogra, S., Whitelaw, M., & May, B. (1998). Transcriptional activation of Cytochrome P450 genes by different classes of chemical inducers. Clinical and Experimental Pharmacology and Physiology, 25(1), 1-9. DOI Scopus70 Europe PMC37
1998	Pongratz, I., Antonsson, C., Whitelaw, M., & Poellinger, L. (1998). Role of the PAS domain in regulation of demerization & DNA binding specificity of the dioxin receptor. Molecular and Cellular Biology, 18(7), 4079-4088. DOI Scopus96 Europe PMC65
1996	McGuire, J., Coumailleau, P., Whitelaw, M. L., Gustafsson, J. -Å., & Poellinger, L. (1996). The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:. Journal of Biological Chemistry, 270(52), 31353-31357. DOI Scopus55 Europe PMC31
1996	Gradin, K., McGuire, J., Wenger, R., Kvietikova, I., Whitelaw, M., Toftgard, R., . . . Poellinger, L. (1996). Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Molecular and Cellular Biology, 16(10), 5221-5231. DOI Scopus396 Europe PMC244
1995	Coumailleau, P., Poellinger, L., Gustafsson, J. A., & Whitelaw, M. L. (1995). Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity. Journal of Biological Chemistry, 270(42), 25291-25300. DOI Scopus146 Europe PMC87
1995	Lindebro, M. C., Poellinger, L., & Whitelaw, M. L. (1995). Protein-protein interaction via PAS domains: Role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO Journal, 14(14), 3528-3539. DOI Scopus168 Europe PMC107
1995	Antonsson, C., Arulampalam, V., Whitelaw, M. L., Pettersson, S., & Poellinger, L. (1995). Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif. Journal of Biological Chemistry, 270(23), 13968-13972. DOI Scopus90 Europe PMC49
1995	Antonsson, C., Whitelaw, M. L., Mcguire, J., Gustafsson, J. A., & Poellinger, L. (1995). Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains. Molecular and Cellular Biology, 15(2), 756-765. DOI Scopus103 Europe PMC60
1995	Whitelaw, M. L., Mcguire, J., Picard, D., Gustafsson, J. A., & Poellinger, L. (1995). Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proceedings of the National Academy of Sciences of the United States of America, 92(10), 4437-4441. DOI Scopus117 Europe PMC60
1994	Mason, G. G. F., Witte, A. M., Whitelaw, M. L., Antonsson, C., McGuire, J., Wilhelmsson, A., . . . Gustafsson, J. A. (1994). Purification of the DNA binding form of dioxin receptor: Role of the Arnt cofactor in regulation of dixon receptor function. Journal of Biological Chemistry, 269(6), 4438-4449. DOI Scopus57 Europe PMC35
1994	Gradin, K., Whitelaw, M. L., Toftgård, R., Poellinger, L., & Berghard, A. (1994). A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. Journal of Biological Chemistry, 269(38), 23800-23807. DOI Scopus59 Europe PMC28
1994	Whitelaw, M. L., Gustafsson, J. A., & Poellinger, L. (1994). Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation. Molecular and Cellular Biology, 14(12), 8343-8355. DOI Scopus154 Europe PMC88
1994	McGuire, J., Whitelaw, M. L., Pongratz, I., Gustafsson, J. A., & Poellinger, L. (1994). A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor. Molecular and Cellular Biology, 14(4), 2438-2446. DOI Scopus125 Europe PMC70
1994	Wilhelmsson, A., Whitelaw, M. L., Gustafsson, J. A., & Poellinger, L. (1994). Agonistic and antagonistic effects of α-naphthoflavone on dioxin receptor function: Role of the basic region helix-loop-helix dioxin receptor partner factor arnt. Journal of Biological Chemistry, 269(29), 19028-19033. DOI Scopus72 Europe PMC44
1993	Berghard, A., Gradin, K., Pongratz, I., Whitelaw, M., & Poellinger, L. (1993). Cross-Coupling of Signal Transduction Pathways: The Dioxin Receptor Mediates Induction of Cytochrome P-450IA1 Expression via a Protein Kinase C-Dependent Mechanism. Molecular and Cellular Biology, 13(1), 677-689. DOI Scopus162 Europe PMC84
1993	Whitelaw, M., Pongratz, I., Wilhelmsson, A., Gustafsson, J. A., & Poellinger, L. (1993). Ligand-dependent recruitment of the arnt coregulator determines DNA recognition by the dioxin receptor. Molecular and Cellular Biology, 13(4), 2504-2514. DOI Scopus204 Europe PMC99
1993	Whitelaw, M. L., Göttlicher, M., Gustafsson, J. A., & Poellinger, L. (1993). Definition of a novel ligand binding domain of a nuclear bHLH receptor: Co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor. EMBO Journal, 12(11), 4169-4179. DOI Scopus140 Europe PMC76
1991	Whitelaw, M. L., Hutchison, K., & Perdew, G. H. (1991). A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60<sup>v-src</sup> hsp90 in cells transformed by the rous sarcoma virus. Journal of Biological Chemistry, 266(25), 16436-16440. DOI Scopus93 Europe PMC39
1991	Whitelaw, M. L., Chung, H. J., & Daniel, J. R. (1991). Synthesis and sensory evaluation of ring-substituted dihydrochalcone sweeteners. 2. Analogues of 3′-carboxyhesperetin dihydrochalcone, a high-potency dihydrochalcone sweetener. Journal of Agricultural and Food Chemistry, 39(4), 663-667. DOI Scopus21
1991	Whitelaw, M. L., & Daniel, J. R. (1991). Synthesis and Sensory Evaluation of Ring-Substituted Dihydrochalcone Sweeteners. Journal of Agricultural and Food Chemistry, 39(1), 44-51. DOI Scopus14
1991	Perdew, G. H., & Whitelaw, M. L. (1991). Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with M<inf>r</inf> of 63,000, 56,000, and 50,000. Journal of Biological Chemistry, 266(11), 6708-6713. DOI Scopus171 Europe PMC68
1991	Wood, K. V., Bonham, C. C., Whitelaw, M. L., & Daniel, J. R. (1991). Mass spectra of substituted dihydrocbalcones. Organic Mass Spectrometry, 26(1), 45-46. DOI Scopus2
1988	WHITELAW, M. L., & WEAVER, C. M. (1988). Maillard Browning Effects on In Vitro Availability of Zinc. Journal of Food Science, 53(5), 1508-1510. DOI Scopus17

Conference Papers

Year	Citation
2008	Gorman, J. J., Dave, K. A., Whelan, F., Hamilton, B. R., Wallis, T. P., Headlam, M. J., . . . Whitelaw, M. L. (2008). Comparison of Stable-Isotope Labelling Strategies for Quantification of Phosphosite Occupancy and Differentiation Between Phosphorylation and Sulfonation of the Murine Dioxin Receptor. In Journal of Proteomics & Bioinformatics Vol. S2 (pp. 067-068). OMICS Publishing Group. DOI

Conference Items

Year	Citation
2012	Hao, N., Shearwin, K., Dodd, I., Whitelaw, M., & Chapman-Smith, A. (2012). Reverse Bacterial Two Hybrid: A New Tool for Studying Dimeric Protein Interactions. Poster session presented at the meeting of ASBMB ComBio conference. Adelaide.
2009	Hao, N., Shearwin., Dodd, I., Whitelaw, M., & Chapman-Smith, A. (2009). Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions. Poster session presented at the meeting of Network in Genes and Environment in Development (NGED) Forum. Palm Cove, Queensland.
2009	Hao, N., Shearwin, K., Dodd, I., Whitelaw, M., & Chapman-smith, A. (2009). A novel Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions and screening for potential therapeutics. Poster session presented at the meeting of Australian Society for Medical Research (ASMR) SA Scientific Meeting. Adelaide.

Patents

Year	Citation
2009	Whitelaw, M., Peet, D., Karttunen, S., Lando, D., & Gorman, J. (2009). 2002331444, Asparagine Hydroxylation of the CAD Domain of a HIF Protein. Australia.
2008	Whitelaw, M., Peet, D., Karttunen, S., Gorman, J., & Lando, D. (2008). 7435555, Asparagine Hydroxylation of the CAD Domain of a HIF Protein. United States.
2006	Gustafsson, M., Lendahl, U., Bondesson Bolin, M., Poellinger, L., Pereira, T., Ruas, J., . . . Peet, D. (2006). Int App No: PCT/IB2006/000785, Modulation of cellular hypoxia responses through Notch signalling. Sweden.
2002	Whitelaw, M., Lando, D., Peet, D., Gorman, J., & Karttunen, S. (2002). Int App. PCT/AU2002/001290, Asparagine hydroxylation of the CAD domain of a HIF protein. Australia.

Theses

Year	Citation
2012	Hao, N. (2012). Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt. (PhD Thesis, The University of Adelaide).
2007	Hao, N. (2007). Searching for HIF-1α/Arnt PAS Domain Interacting Proteins. (The University of Adelaide).

Preprint

Year	Citation
2023	Allen, T., Roennfeldt, A., Reckdharajkumar, M., Liu, M., Quinn, R., Russell, D., . . . Bersten, D. (2023). dFLASH; dual FLuorescent transcription factor Activity Sensor for Histone integrated live-cell reporting and high-content screening. DOI

National Health and Medical Research Council

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2019 - 2024	Principal Supervisor	Development and application of dual fluorescent reporting systems for HIF-1 alpha and other transcription factor pathways	Doctor of Philosophy	Doctorate	Full Time	Mr Timothy Patrick Allen
2017 - 2021	Co-Supervisor	Understanding PPARg-Ligand Interactions to Treat Type 2 Diabetes	Doctor of Philosophy	Doctorate	Full Time	Miss Rebecca Louise Frkic
2017 - 2022	Co-Supervisor	Molecular Drivers of Aerobic Glycolysis in the Mammalian Retina	Doctor of Philosophy	Doctorate	Full Time	Mr Cameron David Haydinger
2015 - 2021	Principal Supervisor	Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2	Doctor of Philosophy	Doctorate	Full Time	Miss Alexis Georgia Gerassimou
2014 - 2019	Co-Supervisor	Identification and Validation of SOXB1 Bound Developmental Enhancers	Doctor of Philosophy	Doctorate	Full Time	Ella Paulina Thomson
2014 - 2020	Co-Supervisor	Investigating the Warburg effect and the role of pyruvate kinase M2 in retinal Müller glial cells	Doctor of Philosophy	Doctorate	Full Time	Miss Thaksaon Kittipassorn
2014 - 2023	Principal Supervisor	Function and Mechanism of The Single-Minded 2 Gene	Doctor of Philosophy	Doctorate	Full Time	Emily Lyn Button
2013 - 2018	Co-Supervisor	Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH	Doctor of Philosophy	Doctorate	Full Time	Miss Jacqueline-Alba Fabrizio
2012 - 2017	Co-Supervisor	A Role for Bivalent Genes in Epithelial to Mesenchymal Transition	Doctor of Philosophy	Doctorate	Part Time	Mr Francisco Sadras
2011 - 2017	Co-Supervisor	Development and Applications of CRISPR/Cas9 Genome Editing Technology	Doctor of Philosophy	Doctorate	Full Time	Dr Fatwa Adikusuma
2011 - 2018	Co-Supervisor	Investigating the Role of HIF-1 and HIF-2 Transcription Factors in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Natalia Magdalena Martin
2009 - 2016	Principal Supervisor	Function and Regulation of Single-minded 1 and Single-minded 2 Transcription Factors in Disease	Doctor of Philosophy	Doctorate	Full Time	Ms Adrienne Sullivan
2009 - 2020	Co-Supervisor	Deciphering the Transcriptional Mechanisms and Function of SOX3 in the Developing Embryonic Mouse Brain and Postnatal Testes	Doctor of Philosophy	Doctorate	Full Time	Mr Dale Christopher McAninch
2008 - 2012	Principal Supervisor	Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt	Doctor of Philosophy	Doctorate	Full Time	Dr Nan Hao
2007 - 2012	Co-Supervisor	Characterising Ankyrin Repeat Proteins as Substrates of the Asparaginyl Hydroxylase FIH	Doctor of Philosophy	Doctorate	Full Time	Miss Sarah Wilkins
2006 - 2011	Principal Supervisor	Identification of Downstream Target Genes and Analysis of Obesity-Related Variants of the bHLH/PAS Transcription Factor Single-Minded 1	Doctor of Philosophy	Doctorate	Full Time	Miss Anne Raimondo
2006 - 2012	Co-Supervisor	Expression and Function of Npas4 During Early Development	Doctor of Philosophy	Doctorate	Full Time	Dr Tom Klaric
2006 - 2012	Co-Supervisor	Regulation of the Rgs4 Gene by the Hypoxia Inducible Factors	Doctor of Philosophy	Doctorate	Full Time	Mr Sam Olechnowicz
2006 - 2014	Principal Supervisor	Regulation of Expression and Activity of the bHLH-PAS Transcription Factor NPAS4	Doctor of Philosophy	Doctorate	Full Time	Dr David Bersten
2005 - 2006	Principal Supervisor	The Role of Glycogen Synthase Kinase-3 in Early Embryonic Stem Cell Differentiation	Master of Science	Master	Full Time	Mr Cameron McLean
2005 - 2011	Co-Supervisor	Investigation into The Molecular Function of The Neuronal Hu RNA Binding Protein, HuCsv1	Doctor of Philosophy	Doctorate	Full Time	Mr Peter McCarthy
2005 - 2011	Co-Supervisor	Investigating Potential Post-Translational Modification of Factor-Inhibiting HIF (FIH-1)	Doctor of Philosophy	Doctorate	Full Time	Ms Karolina Lisy
2005 - 2016	Co-Supervisor	Identification and Characterisation of Novel Substrates and Binding Partners of the Asparaginyl Hydroxylase, FIH	Doctor of Philosophy	Doctorate	Part Time	Ms Rachel Hampton-Smith
2004 - 2008	Co-Supervisor	Substrate Specificity of Factor Inhibiting HIF-1 (FIH-1)	Doctor of Philosophy	Doctorate	Full Time	Dr Sarah Karttunen
2004 - 2009	Principal Supervisor	Gene Regulatory and Pro-Tumourigenic Mechanisms of the bHLH-PAS Transcription Factor SIM2s	Doctor of Philosophy	Doctorate	Full Time	Ms Alexandra Farrall
2004 - 2010	Co-Supervisor	The Deubiquitylating Enzyme USP9X Promotes the Polarity and Self-Renewal of Neural Progenitor Cells	Doctor of Philosophy	Doctorate	Full Time	Dr Lachlan Jolly
2003 - 2005	Principal Supervisor	Differential Function and Regulation of the Hypoxia Inducible Factors in the Rat Pheochromocytoma Cell Line Pc12	Doctor of Philosophy	Doctorate	Full Time	Mr Anthony Fedele
2003 - 2009	Principal Supervisor	The Aryl Hydrocarbon Receptor: Structural Analysis and Activation Mechanisms	Doctor of Philosophy	Doctorate	Full Time	Dr Fiona Whelan
2002 - 2004	Co-Supervisor	Mechanisms of embryonic stem cell division and differentiation	Doctor of Philosophy	Doctorate	Full Time	Dr Josephine Amelia Wright
2001 - 2005	Principal Supervisor	Characterising the Differential Regulation of Hypoxia-Inducible Factor 1a and 2a	Doctor of Philosophy	Doctorate	Full Time	APrf Cameron Bracken
1999 - 2004	Principal Supervisor	NOVEL MECHANISMS FOR ACTIVATION OF THE DIOXIN (ARYL-HYDROCARBON) RECEPTOR	Doctor of Philosophy	Doctorate	Full Time	Mr Sebastian Furness
1999 - 2004	Principal Supervisor	CROSS-TALK BETWEEN SIM & OTHER bHLH/PAS FACTORS & THE SEARCH FOR SIM2 TARGET GENES	Doctor of Philosophy	Doctorate	Full Time	APrf Susan Lesley Woods
1998 - 2002	Principal Supervisor	CHARACTERISING MECHANISMS OF REGULATION OF HYPOXIA-INDUCIBLE FACTORS	Doctor of Philosophy	Doctorate	Full Time	Dr David Lando
1998 - 2003	Principal Supervisor	INVESTIGATING THE ROLE OF ARNT ISOFORMS AS bHLH/PAS TRANSCRIPTIONAL REGULATORS	Doctor of Philosophy	Doctorate	Full Time	Miss Robyn Kewley
1997 - 2003	Principal Supervisor	Characterising the mechanism of Activation of the bHLH/PAS Dioxin Receptor	Doctor of Philosophy	Doctorate	Full Time	Mr Michael Lees

Email: murray.whitelaw@adelaide.edu.au

Murray Whitelaw

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Education

Postgraduate Training

Research Interests