Lachlan Jolly

Dr Lachlan Jolly

Research Fellow, ARC DECRA Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Our lab discovers the mechanisms by which 'cellular degradation pathways' control cell function during brain development. mRNA and protein degradation pathways display the ability to control the expression of a large number of genes involved in brain development. Our lab employs multidisciplinary and collaborative approaches. We perform functional genomic studies using cell and developmental biology techniques, utilising a variety of cell, stem-cell and neural cell culture models and small animal models to interrogate the roles of cellular degradation pathways in development. 

Major projects.

mRNA Degradation: Nonsense Mediated mRNA Decay (NMD).  NMD is an extremely important pathway because it is essential for embryo viability and degrades large number of endogenous mRNAs. We investigate how NMD controls normal mRNAs important for the function of cells of the brain, and are using our knowledge to devise new methods to both measure and manipulate NMD during development.

Protein Degradation: Ubiquitin Systems We are discovering how large network of proteins encoded are regulated by protein ubiquitination through studies of a network hub gene called USP9X which encodes a deubiquitinating enzyme.

 

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  • Appointments

    Date Position Institution name
    2020 - 2020 Robinson Research Institute Career Development Fellow University of Adelaide
    2016 - 2018 Discovery Early Career Research Fellow Australian Research Council
    2015 - 2015 Senior Lecturer University of Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2019 Award AFGN Meeting Best Post-doc Talk Australian Functional Genomics Network Australia
    2016 Fellowship Discovery Early Career Research Award Australian Research Council Australia 378000
    2013 Award Adelaide Protein Group Early Career Award Australian Society for Biochemistry and Molecular Biology Australia
    2012 Award Toshiya Yamada Early Career Award Australian and New Zealand Society for Cell and Developmental Biology Australia
  • Education

    Date Institution name Country Title
    2005 - 2010 University of Adelaide Australia PhD
  • Postgraduate Training

    Date Title Institution Country
    2013 - 2013 Research Placement University of California, San Diego United States

Successful applications I have been involved in have received in total >$2 million dollars. This includes (Category1) $378K as ARC DECRA , $764K as CIB on NHMRC Project Grant, $238K as CIC on ARC Discovery Grant; and (Category II) $325K as CIA across 5x NFP Grants.

  1. (2010) Chief Investigator A. Women’s and Children’s Hospital Foundation Grant. $50 K. Title “Modelling the molecular pathogenesis of intellectual disability: Functional importance of the nonsense mediated mRNA decay (NMD) factor UPF3B”.
  2. (2011) Chief Investigator A. Women’s and Children’s Hospital Foundation Grant. $50 K. Title “Investigating the cell and molecular neurobiology of Usp9x: resolving the pathological mechanisms behind the genetic causes of intellectual disability”.
  3. (2013) Chief Investigator A. Women’s and Children’s Hospital Foundation Grant. $75K. Title “Molecular pathology of HCFC1, a novel modifier of embryonic neural cell behaviour involved in intellectual disability”.
  4. (2014) Chief Investigator A. Women’s and Children’s Hospital Foundation Grant. $75 K. Title “Rescue of intellectual disability severity through modification of the non-sense mediated mRNA decay factor UPF3A”.           
  5. (2014) Chief Investigator B. NH&MRC Project Grant: 1063808. $764 K. Title “The role of UPF3B and nonsense mediated mRNA decay surveillance in the pathology of intellectual disability”.
  6. (2015) Chief Investigator A. Channel 7 Children’s Foundation Grant. $75 K. Title “Visualising Nonsense Mediated mRNA Decay”.
  7. (2015) Chief Investigator B. RRI Innovation Seed Funding Program. $30 K. Title “CRISP-up: a novel Crispr/Cas9 based approach to gene overexpression”.
  8. (2016) Chief Investigator A. RRI Innovation Seed Funding Program. $25 K. Title “Generation of Pluripotent Stem Models for the study of Human Neurodevelopmental Disorders”.
  9. (2016) Chief Investigator C. RRI Innovation Seed Funding Program. $25 K. Title “The impact of Zika virus infection on placenta and neural development during early gestation”.
  10. (2017) Chief Investigator C. ARC Discovery Grant: DP170103090. $234 K. Title “TREX-mediated mRNA export: critical pathways in differentiation and function”.
  11. (2017) Co-PI. Penn Medicine Orphan Disease Centre. $70K. Titled “Understanding neurogenesis in MPS IIIA disease”.
  12. (2017) Chief Investigator C. SAFRI Simons Autism Funds. $100K. Title “USP9X in Autism”
  13. (2018) Chief Investigator A. RRI Invest for Success Funding Program. 20K. Title “Control of postnatal hippocampal development by intellectual disability genes”.
  14. (2019) Chief Investigator A. RRI Invest for Success Funding Program. 30K. Title “Control of postnatal hippocampal development by intellectual disability genes”.

Fellowships

  1. (2016-2018) ARC Discovery Early Career Research Award (DECRA): DE160100620. $378 K. Title “Seeing through the nonsense: Gene regulation and the nonsense mediated mRNA decay pathway”.
  2. (2020) Robinson Research Institute Career Development Fellowship. $100K. Title “Cellular Degradation Pathways In Neurodevelopmental Disorders”

HDR Students

  1. (2012-18). PhD. Dr Claire Homan, University of Adelaide.
  2. (2016-18). PhD. Dr Rebecca Lehmann, University of Adelaide.
  3. (2014). Undergraduate placement. Ms Deepti Domingo, University of Adelaide.
  4. (2013-20). PhD. Dr Debrah Renders, University of Adelaide.
  5. (2015-20). PhD. Dr Deepti Domingo, University of Adelaide.
  6. (2020-21). Masters. Ms Emmylou Nicolas. 

Undergraduate Lectures

  1. (2016-current) University of Adelaide: Biomedical Science II, Adelaide, Australia
  2. (2018-current) University of Adelaide: Cellular Neuroscience III, Adelaide, Australia
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  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 - 2019 Co-Supervisor The Neurogenic Potential of Stem Cells is Altered in Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Rebecca Jayne Lehmann
    2016 - 2020 Co-Supervisor A Study of Nonsense Mediated mRNA Decay using Naturally Occurring Genetic Variants and Through the Development of a Synthetic Transgene Doctor of Philosophy Doctorate Full Time Miss Deepti Dianna Domingo
    2014 - 2020 Co-Supervisor The Role of UPF3A and UPF3B in Early Development and Neural Differentiation Doctor of Philosophy Doctorate Full Time Ms Debrah Sadie Sebolai
    2012 - 2017 Co-Supervisor Neurobiology of PCDHI9-Female Epilepsy Doctor of Philosophy Doctorate Full Time Dr Claire Homan
  • Position: Research Fellow, ARC DECRA Fellow
  • Phone: 81616363, 83132454
  • Email: lachlan.jolly@adelaide.edu.au
  • Campus: Womens & Childrens Hospital, North Terrace
  • Building: WCH - Clarence Rieger Building, floor 2,Adelaide Health and Medical Sciences, floor 8
  • Room: WS8071.18
  • Org Unit: Women's and Children's Health

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