Claire Homan

Research Interests

Neuroscience, Behaviour and Brain Health Biochemistry and Cell Biology Genetics Neurogenetics Cancer Biology and Clinical Oncology Cancer Genetics

Claire Homan

Centre for Cancer Biology

College of Health

Dr Homan is a research fellow at the Centre for Cancer Biology, with a strong track-record of multi-disciplinary research spanning human genetics, genomics, haematological malignancies and developmental biology. Her research has provided impactful contributions to understanding genetic disease mechanisms including clinical, genetic, and functional evidence of novel-gene pathogenicity. Dr. Homan’s research in inherited haematological malignancies has a focus on elucidating biological mechanisms driving disease progression and development to apply a personalised-medicine approach to patient care. Her overarching objective is to develop novel clinical interventions for enhanced monitoring, prevention, and therapy. Dr. Homan is pioneering work into the characterisation of genetic mouse models of predisposition to MDS/AML and developing translational models for the development of novel therapies.

Date Position Institution name
2017 - ongoing Research Associate University of Adelaide, Adelaide

Date Institution name Country Title
University of Adelaide, Adelaide Australia PhD

Year Citation
2025 Homan, C. C., Scott, H. S., & Venugopal, P. (2025). Another Fanconi anemia gene joins the club. Journal of Clinical Investigation, 135(11), e192382-1-e192382-4.
DOI Europe PMC1
2024 Zerella, J. R., Homan, C. C., Arts, P., Lin, X., Spinelli, S. J., Venugopal, P., . . . Hahn, C. N. (2024). Germline ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition. Blood, 144(17), 1765-1780.
DOI Scopus8 WoS7 Europe PMC6
2023 Homan, C. C., Scott, H. S., & Brown, A. L. (2023). Hereditary platelet disorders associated with germline variants in RUNX1, ETV6 and ANKRD26. Blood, 141(13), 1533-1543.
DOI Scopus39 WoS40 Europe PMC35
2023 Zerella, J. R., Homan, C. C., Arts, P., Brown, A. L., Scott, H. S., & Hahn, C. N. (2023). Transcription factor genetics and biology in predisposition to bone marrow failure and hematological malignancy. Frontiers in Oncology, 13, 1-33.
DOI Scopus3 WoS3 Europe PMC4
2023 Homan, C. C., Drazer, M. W., Yu, K., Lawrence, D. M., Feng, J., Arriola-Martinez, L. A., . . . Brown, A. L. (2023). Somatic mutational landscape of hereditary hematopoietic malignancies caused by germ line RUNX1, GATA2, and DDX41 variants. Blood Advances, 7(20), 6092-6107.
DOI Scopus29 WoS26 Europe PMC22
2023 Saygin, C., Roloff, G. W., Hahn, C. N., Chhetri, R., Gill, S. I., Elmariah, H., . . . Godley, L. A. (2023). Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies. Blood Advances, 7(4), 549-554.
DOI Scopus41 WoS42 Europe PMC36
2022 Drazer, M. W., Homan, C. C., Yu, K., Cavalcante de Andrade Silva, M., McNeely, K. E., Pozsgai, M. J., . . . Godley, L. A. (2022). Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.. Blood Adv, 6(15), 4357-4359.
DOI Scopus21 WoS21 Europe PMC16
2022 Feurstein, S., Luo, X., Shah, M., Walker, T., Mehta, N., Wu, D., & Godley, L. A. (2022). Revision of RUNX1 variant curation rules. Blood Advances, 6(16), 4726-4730.
DOI Scopus13 WoS11 Europe PMC10
2021 Tasheva, S., Nieto Guil, A. F., Homan, C. C., Gecz, J., & Thomas, P. Q. (2021). Disrupted excitatory synaptic contacts and altered neuronal network activity underpins the neurological phenotype in PCDH19-clustering epilepsy (PCDH19-CE). Molecular Neurobiology, 58(5), 2005-2018.
DOI Scopus21 WoS20 Europe PMC18
2021 Homan, C. C., King-Smith, S. L., Lawrence, D. M., Arts, P., Feng, J., Andrews, J., . . . Brown, A. L. (2021). The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.. Haematologica, 106(11), 3004-3007.
DOI Scopus42 WoS37 Europe PMC32
2021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). GATA2 deficiency syndrome: a decade of discovery. Human Mutation, 42(11), 1399-1421.
DOI Scopus51 WoS43 Europe PMC41
2021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). Cover, Volume 42, Issue 11. Human Mutation, 42(11).
DOI
2020 Brown, A. L., Arts, P., Carmichael, C. L., Babic, M., Dobbins, J., Chong, C. -E., . . . Scott, H. S. (2020). RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Advances, 4(6), 1131-1144.
DOI Scopus129 WoS117 Europe PMC106
2019 Jackson, M. R., Loring, K. E., Homan, C. C., Thai, H. N., Määttänen, L., Arvio, M., . . . Shoubridge, C. (2019). Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females. Life Science Alliance, 2(4), e201900386-1-e201900386-18.
DOI Scopus19 WoS17 Europe PMC17
2018 Homan, C., Pederson, S., To, T. -H., Tan, C., Piltz, S., Corbett, M., . . . Gecz, J. (2018). PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy. Neurobiology of Disease, 116, 106-119.
DOI Scopus44 WoS38 Europe PMC38
2018 Kumar, R., Gardner, A., Homan, C., Douglas, E., Mefford, H., Wieczorek, D., . . . Gecz, J. (2018). Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. Human mutation, 39(8), 1126-1138.
DOI Scopus21 WoS23 Europe PMC21
2018 Jolly, L., Sun, Y., Carroll, R., Homan, C., & Gecz, J. (2018). Robust imaging and gene delivery to study human lymphoblastoid cell lines. Journal of Human Genetics, 63(9), 945-955.
DOI Scopus2 WoS2 Europe PMC2
2017 Pham, D., Tan, C., Homan, C., Kolc, K. L., Corbett, M., McAninch, D., . . . Gecz, J. (2017). Protocadherin 19 (PCDH19) interacts with paraspeckle protein NONO to co-regulate gene expression with estrogen receptor alpha (ERα). Human Molecular Genetics, 26(11), 2042-2052.
DOI Scopus27 WoS25 Europe PMC25
2016 Pederick, D., Homan, C., Jaehne, E., Piltz, S., Haines, B., Baune, B., . . . Thomas, P. (2016). Pcdh19 loss-of-function increases neuronal migration in vitro but is dispensable for brain development in mice. Scientific Reports, 6(1), 26765-1-26765-10.
DOI Scopus52 WoS49 Europe PMC48
2014 Homan, C., Kumar, R., Nguyen, L., Haan, E., Raymond, F., Abidi, F., . . . Jolly, L. (2014). Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. American Journal of Human Genetics, 94(3), 470-478.
DOI Scopus119 WoS117 Europe PMC111
2014 Hamon, R., Homan, C., Tran, H., Mukaro, V., Lester, S., Roscioli, E., . . . Hodge, S. (2014). Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD. PLoS ONE, 9(10), e110056-1-e110056-9.
DOI Scopus58 WoS58 Europe PMC49
2013 Jolly, L., Homan, C., Jacob, R., Barry, S., & Gecz, J. (2013). The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. Human Molecular Genetics, 22(23), 4673-4687.
DOI Scopus108 WoS99 Europe PMC103
1979 SUNDEL, M., & HOMAN, C. C. (1979). PREVENTION IN CHILD-WELFARE - FRAMEWORK FOR MANAGEMENT AND PRACTICE. CHILD WELFARE, 58(8), 510-521.
WoS5

Year Citation
2016 Pham, D., Tan, C., Homan, C., Jolly, L., & Gecz, J. (2016). Protocadherin Mutations in Neurodevelopmental Disorders. In C. Sala, & C. Verpelli (Eds.), Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability (1 ed., pp. 221-231). London: Elsevier.
DOI Scopus2

Year Citation
2023 Scott, H. S., Zerella, J., Homan, C., Arts, P., Lin, S., Spinelli, S. J., . . . Hahn, C. N. (2023). ERG Is a New Predisposition Gene for Bone Marrow Failure and Hematological Malignancy. In BLOOD Vol. 144 (pp. LBA8). CA, San Diego: ELSEVIER.
DOI WoS2
2022 Saygin, C., Roloff, G. W., Hahn, C. N., Chhetri, R., Gill, S., Elmariah, H., . . . Godley, L. A. (2022). Allogeneic Hematopoietic Stem Cell Transplant Outcomes in Adults with Inherited Myeloid Malignancies. In BLOOD Vol. 140 (pp. 10542-10544). LA, New Orleans: ELSEVIER.
DOI
2022 Brown, A. L., Homan, C., Drazer, M. W., Yu, K., Lawrence, D., Feng, J., . . . Godley, L. A. (2022). Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in <i>RUNX1</i>, <i>GATA2</i> and <i>DDX41</i>. In BLOOD Vol. 140 (pp. 4030-4033). LA, New Orleans: AMER SOC HEMATOLOGY.
DOI WoS5
2019 Homan, C., Armstrong, M., Dobbins, J., Lawrence, D., Wang, P., Arts, P., . . . Brown, A. (2019). DEVELOPMENT OF A DATA PORTAL FOR AGGREGATION AND ANALYSIS OF GENOMICS DATA IN FAMILIAL PLATELET DISORDER WITH PREDISPOSITION TO MYELOID MALIGNANCY - THE RUNX1.DB. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S69). ELSEVIER SCIENCE INC.
2019 Cheah, J., Brown, A., Eshraghi, L., Feng, J., Schreiber, A., Babic, M., . . . Scott, H. (2019). AN INTEGRATIVE GENOMIC APPROACH TO EXAMINE MUTATIONS AND BIOLOGICAL PATHWAYS ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCY DEVELOPMENT IN DDX41 MUTATED FAMILIES. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S61). ELSEVIER SCIENCE INC.
2019 Venugopal, P., Cheah, J. J. C., Eshraghi, L., Shahrin, N. H., Homan, C., Feng, J., . . . Scott, H. S. (2019). An Integrative Genomic Approach to Examine Mutations and Biological Pathways Associated with Hematological Malignancy Development in DDX41 Mutated Families. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
DOI WoS2

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