Fatwa Adikusuma

Dr Fatwa Adikusuma

Postdoctoral Research Scientist

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr Adikusuma is a research fellow in Genome Editing Laboratory led by Prof Paul Thomas. He completed his PhD at the University of Adelaide under Prof Thomas supervision. He is the recipient of a fellowship from CSIRO Synthetic Biology Future Science Platform. Dr Adikusuma discovered the strategies to eliminate an entire chromosome using CRISPR genome editing. Also, his landmark finding that CRISPR-Cas9 cleavage often induces large deletions (Adikusuma et al Nature 2018) cautions the biomedical community about unintended and hitherto unrecognised editing outcomes that could occur when performing germline CRISPR genome editing therapy. Together with his students and Prof Thomas, he is now developing a highly efficient strategy of using CRISPR genome editing for therapeutic of Duchenne Muscular Dystrophy that could lead to effective clinical genome editing therapy using CRISPR system.

CRISPR technology enables us to easily modify genomic sequences. It has emerged as a potential candidate for disease therapeutics, particularly for genetic diseases. My research aims to develop genome editing techniques and strategies using CRISPR technology and apply those for therapeutic purposes. One of my current research projects focuses on developing highly effective CRISPR therapy for a muscle-wasting genetic disease called Duchenne Muscular Dystrophy (DMD). We use DMD mouse models to test our CRISPR techniques in order to find the perfect formula that can effectively cure the disease. We will also try to translate our CRISPR techniques for use in humans to provide treatment for DMD patients.

CSIRO SynBio fellowship for developing genome editing strategies for DMD therapeutic

- Advanced Research Platforms, Masters of Biotechnology

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