Fatwa Adikusuma

Dr Fatwa Adikusuma

Postdoctoral Research Scientist

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr Adikusuma is a research fellow in Genome Editing Laboratory led by Prof Paul Thomas. He completed his PhD at the University of Adelaide under Prof Thomas supervision. He is the recipient of a fellowship from CSIRO Synthetic Biology Future Science Platform. Dr Adikusuma discovered the strategies to eliminate an entire chromosome using CRISPR genome editing. Also, his landmark finding that CRISPR-Cas9 cleavage often induces large deletions (Adikusuma et al Nature 2018) cautions the biomedical community about unintended and hitherto unrecognised editing outcomes that could occur when performing germline CRISPR genome editing therapy. Together with his students and Prof Thomas, he is now developing a highly efficient strategy of using CRISPR genome editing for therapeutic of Duchenne Muscular Dystrophy that could lead to effective clinical genome editing therapy using CRISPR system.

My research is focused on developing CRISPR genome editing technology particularly for its use in mammalian cells and in mice. I explore CRISPR strategies that promote predictable and efficient DNA editing outcomes. For example, I invented the strategies to eliminate an entire chromosome using CRISPR genome editing (Adikusuma et al Molecular Therapy 2017). My research also studies how we can efficiently and effectively create genomic mutations using CRISPR technology and develop the CRISPR tools (constructs) to achieve the goal. Additionally, I study the repair outcomes (mutations) generated after DNA breaks induced by CRISPR endonuclease. For example, we found that CRISPR-Cas9 cleavage often induces large deletions (Adikusuma et al Nature 2018). The main goal of my research is to create knowledge and technology on genome editing that is widely used for vast applications such as basic research and therapeutics. One of my current research projects focuses on developing highly effective CRISPR therapy for a muscle-wasting genetic disease called Duchenne Muscular Dystrophy (DMD). We use DMD mouse models to test our CRISPR techniques in order to find the perfect formula that can effectively cure the disease. We will also try to translate our CRISPR techniques for use in humans to provide treatment for DMD patients.

CSIRO SynBio fellowship for developing genome editing strategies for DMD therapeutic

- Advanced Research Platforms, Masters of Biotechnology

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2020 Co-Supervisor Development of novel CRISPR/Cas9 therapies for genetic eye disease Master of Philosophy (Medical Science) Master Full Time Ms Ashleigh Geiger
    2020 Co-Supervisor Developing CRISPR/Cas9-Based Therapy for Duchenne Muscular Dystrophy using a Humanised Preclinical Model Doctor of Philosophy Doctorate Full Time Mr Yu Chinn Joshua Chey
    2020 Co-Supervisor Development of a highly efficient CRISPR-Cas9 gene therapy strategy for precise restoration of dystrophin in Duchenne Muscular Dystrophy (DMD) Doctor of Philosophy Doctorate Full Time Mr Jayshen Christa Arudkumar

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