Postdoctoral Research Scientist
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Adikusuma is a research fellow in Genome Editing Laboratory led by Prof Paul Thomas. He completed his PhD at the University of Adelaide under Prof Thomas supervision. He is the recipient of a fellowship from CSIRO Synthetic Biology Future Science Platform. Dr Adikusuma discovered the strategies to eliminate an entire chromosome using CRISPR genome editing. Also, his landmark finding that CRISPR-Cas9 cleavage often induces large deletions (Adikusuma et al Nature 2018) cautions the biomedical community about unintended and hitherto unrecognised editing outcomes that could occur when performing germline CRISPR genome editing therapy. Together with his students and Prof Thomas, he is now developing a highly efficient strategy of using CRISPR genome editing for therapeutic of Duchenne Muscular Dystrophy that could lead to effective clinical genome editing therapy using CRISPR system.
CRISPR technology enables us to easily modify genomic sequences. It has emerged as a potential candidate for disease therapeutics, particularly for genetic diseases. My research aims to develop genome editing techniques and strategies using CRISPR technology and apply those for therapeutic purposes. One of my current research projects focuses on developing highly effective CRISPR therapy for a muscle-wasting genetic disease called Duchenne Muscular Dystrophy (DMD). We use DMD mouse models to test our CRISPR techniques in order to find the perfect formula that can effectively cure the disease. We will also try to translate our CRISPR techniques for use in humans to provide treatment for DMD patients.
Date Position Institution name 2018 Research Fellow University of Adelaide, Adelaide 2017 - 2018 Postdoctoral Researcher University of Adelaide, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award Early Career Researcher Award SAHMRI Australia — 2018 Fellowship CSIRO SynBio Fellowship CSIRO, University of Adelaide and SAHMRI Australia —
Date Institution name Country Title 2011 - 2017 University of Adelaide, Adelaide Australia PhD
Year Citation 2019 Prowse, T., Adikusuma, F., Cassey, P., Thomas, P., & Ross, J. (2019). A Y-chromosome shredding gene drive for controlling pest vertebrate populations. eLife, 8, 19 pages.
DOI Scopus5 WoS4 Europe PMC2
2018 Robertson, L., Pederick, D., Piltz, S., White, M., Nieto, A., Ahladas, M., . . . Thomas, P. Q. (2018). Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing.. The CRISPR journal, 1(6), 431-439.
2018 Adikusuma, F., Piltz, S., Corbett, M., Turvey, M., McColl, S., Helbig, K., . . . Thomas, P. (2018). Large deletions induced by Cas9 cleavage. Nature, 560(7717), E8-E9.
DOI Scopus38 WoS39 Europe PMC15
2017 Van Der Hoek, K., Eyre, N., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J., . . . Beard, M. (2017). Viperin is an important host restriction factor in control of Zika virus infection. Scientific Reports, 7(1), 4475 -1-4475-14.
DOI Scopus44 WoS44 Europe PMC27
2017 Adikusuma, F., Pederick, D., McAninch, D., Hughes, J., & Thomas, P. (2017). Functional equivalence of the SOX2 and SOX3 transcription factors in the developing mouse brain and testes. Genetics, 206(3), 1495-1503.
DOI Scopus11 WoS11 Europe PMC8
2017 Adikusuma, F., Williams, N., Grutzner, F., Hughes, J., & Thomas, P. (2017). Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9. Molecular Therapy, 25(8), 1736-1738.
DOI Scopus18 WoS19 Europe PMC11
2017 Adikusuma, F., Pfitzner, C., & Thomas, P. (2017). Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression. PloS one, 12(12), 1-11.
DOI Scopus7 WoS6 Europe PMC3
2014 Piltz, S., Adikusuma, F., Hughes, J., & Thomas, P. (2014). Rapid generation of mutant mice using CRISPR-mediated genome editing (tips and tricks). TRANSGENIC RESEARCH, 23(5), 867.
Year Citation 2014 Piltz, S. G. (2014). Rapid generation of mutant mice using CRISPR mediated genome editing (tips and tricks). Poster session presented at the meeting of Transgenic Research. Ediburgh, UK: Springer.
CSIRO SynBio fellowship for developing genome editing strategies for DMD therapeutic
- Advanced Research Platforms, Masters of Biotechnology
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 Co-Supervisor Developing CRISPR/Cas9-Based Therapy for Duchenne Muscular Dystrophy using a Humanised Preclinical Model Doctor of Philosophy Doctorate Full Time Mr Yu Chinn Joshua Chey 2020 Co-Supervisor Development of novel CRISPR/Cas9 therapies for genetic eye disease Master of Philosophy (Medical Science) Master Full Time Ms Ashleigh Geiger 2019 Co-Supervisor Development of a CRISPR Therapy for Duchenne Muscular Dystrophy Master of Philosophy (Medical Science) Master Full Time Mr Jayshen Christa Arudkumar
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