Caleb Lushington

Caleb Lushington

Higher Degree by Research Candidate

School of Biomedicine

Faculty of Health and Medical Sciences

Caleb is a Doctor of Philosophy candidate at the South Australian Health and Medical Research Institute (SAHMRI) in the Genome Editing Lab, under the Precision Medicine theme. His focus entails the improvement of genome editing systems and strategies for the treatment of Cystic Fibrosis (CF) and Duchenne Muscular Dystrophy (DMD), under the supervision of Prof. Paul Thomas and Dr. Fatwa Adikusuma.

In his Honourary year (BSC), Caleb worked in an interdisciplinary environment using cutting-edge technologies in the field of genome editing. A large focus of his studies have been directed towards the improvement of the Prime Editing system that have since been applied both in vitro and in vivo. These improvements have allowed for the modelling of genetic diseases with high efficiency. 

At the beginning of his PhD he now looks to expand upon previous expertise to further improve editing systems and apply them in a genetic disease setting. This includes the in vitro and in vivo modelling of genetic diseases (CF and DMD) with a more simplified and precise editing system, useful for pathological research. Following this, he intends to underpin the clinical relevance of modified editing systems by applying them in the correction of disease models to healthy disease free subjects.

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