Dr Adrienne Sullivan
Group Leader, Adelaide Centre for Epigenetics
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Adrienne Sullivan is head of the Development and Epigenetics Lab, which seeks to understand the molecular basis for controlling activity of gene enhancers and how this regulation affects the identity, behaviour, and potency of a cell. The selective activation and decommissioning of enhancers through epigenetic remodelling is critical for differentiation of multipotent progenitor cells during development. Conversely, misregulation of enhancers and enhancer remodelling plays a role in carcinogenesis and can underly non-genetic drug resistance in cancer cells. Understanding the molecular biology of these processes and how they produce cellular outcomes is therefore important to understand both development and disease.
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Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Fellowship Rutherford-Crick Fellowship, UK Department for Business, Energy & Industrial Strategy (BEIS) Francis Crick Institute United Kingdom - -
Education
Date Institution name Country Title 2009 - 2016 University of Adelaide Australia PhD -
Postgraduate Training
Date Title Institution Country 2017 - 2023 Postdoctoral Researcher Francis Crick Institute United Kingdom 2017 - 2017 Postdoctoral Training Fellow MRC London Institute of Medical Sciences United Kingdom 2016 - 2016 Postdoctoral Research Associate University of Adelaide Australia
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Journals
Year Citation 2023 Sullivan, A. E. (2023). Epigenetic Control of Cell Potency and Fate Determination during Mammalian Gastrulation. Genes, 14(6), 16 pages.
Scopus22023 Sullivan, A. E., & Santos, S. D. (2023). The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis. Current Opinion in Genetics and Development, 82, 11 pages.
Scopus3 Europe PMC12022 Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity.
Europe PMC12021 Hellewell, J., Russell, T. W., Matthews, R., Severn, A., Adam, S., Enfield, L., . . . Gigli, C. C. (2021). Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections. BMC Medicine, 19(1), 10 pages.
Scopus80 Europe PMC892021 Balestrini, S., Koepp, M. J., Gandhi, S., Rickman, H. M., Shin, G. Y., Houlihan, C. F., . . . Goldstone, R. (2021). Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy. Epilepsy and Behavior, 115, 1-10.
Scopus10 Europe PMC92021 Hao, N., Sullivan, A. E., Shearwin, K. E., & Dodd, I. B. (2021). The loopometer: a quantitative in vivo assay for DNA-looping proteins. Nucleic Acids Research, 49(7), 1-16.
Scopus5 WoS5 Europe PMC42020 Houlihan, C. F., Vora, N., Byrne, T., Lewer, D., Kelly, G., Heaney, J., . . . Gutierrez, M. G. (2020). Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers. The Lancet, 396(10246), e6-e7.
Scopus155 WoS131 Europe PMC1432020 Aitken, J., Ambrose, K., Barrell, S., Beale, R., Bineva-Todd, G., Biswas, D., . . . Bowker, F. (2020). Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center (Nature Biotechnology, (2020), 38, 8, (927-931), 10.1038/s41587-020-0588-y). Nature Biotechnology, 38(8), 1000.
Europe PMC12020 Aitken, J., Ambrose, K., Barrell, S., Beale, R., Bineva-Todd, G., Biswas, D., . . . Broncel, M. (2020). Scalable and robust SARS-CoV-2 testing in an academic center. Nature Biotechnology, 38(8), 927-931.
Scopus26 WoS17 Europe PMC262020 Gunne-Braden, A., Sullivan, A., Gharibi, B., Sheriff, R. S. M., Maity, A., Wang, Y. F., . . . Santos, S. D. M. (2020). GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Cell Stem Cell, 26(5), 693-706.e9.
Scopus47 WoS31 Europe PMC382020 Sullivan, A. E., & Santos, S. D. M. (2020). An Optimized Protocol for ChIP-Seq from Human Embryonic Stem Cell Cultures. STAR Protocols, 1(2), 20 pages.
Scopus14 WoS3 Europe PMC152020 Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., . . . Atwal, P. S. (2020). Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.. J Clin Endocrinol Metab, 105(1), 355-361.
Scopus12 WoS6 Europe PMC72017 Moir, L., Bochukova, E. G., Dumbell, R., Banks, G., Bains, R. S., Nolan, P. M., . . . Cox, R. D. (2017). Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6(11), 1419-1428.
Scopus16 WoS8 Europe PMC112016 Sullivan, A., Peet, D., & Whitelaw, M. (2016). MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS Journal, 283(18), 3488-3502.
Scopus10 WoS10 Europe PMC102015 Bersten, D., Sullivan, A., Li, D., Bhakti, V., Bent, S., & Whitelaw, M. (2015). Inducible and reversible lentiviral and recombination mediated cassette exchange (RMCE) systems for controlling gene expression. PLoS One, 10(3), e0116373-1-e0116373-20.
Scopus5 WoS3 Europe PMC32014 Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
Scopus9 WoS8 Europe PMC82013 Bersten, D., Sullivan, A., Peet, D., & Whitelaw, M. (2013). BHLH-PAS proteins in cancer. Nature Reviews. Cancer, 13(12), 827-841.
Scopus207 WoS159 Europe PMC1592013 Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
Scopus132 WoS98 Europe PMC902013 Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., . . . Farooqi, I. S. (2013). Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016). Journal of Clinical Investigation, 123(8), 3635.
Scopus1- Allen, T. P., Roennfeldt, A. E., Reckdharajkumar, M., Sullivan, A. E., Liu, M., Quinn, R. J., . . . Bersten, D. C. (n.d.). dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening. Nature Communications, 16(1).
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Preprint
Year Citation 2024 Pitino, E., Pascual-Reguant, A., Segato-Dezem, F., Wise, K., Salvador-Martinez, I., Crowell, H. L., . . . Martelotto, L. (2024). STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging.
DOI
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2025 Co-Supervisor Exploring the molecular interplay of highly related tumour suppressor proteins that bind identical DNA motifs Master of Philosophy (Medical Science) Master Full Time Miss Katarina Anastasia Amerl
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