Dr Adrienne Sullivan
Group Leader, Adelaide Centre for Epigenetics
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Adrienne Sullivan is head of the Development and Epigenetics Lab, which seeks to understand the molecular basis for controlling activity of gene enhancers and how this regulation affects the identity, behaviour, and potency of a cell. The selective activation and decommissioning of enhancers through epigenetic remodelling is critical for differentiation of multipotent progenitor cells during development. Conversely, misregulation of enhancers and enhancer remodelling plays a role in carcinogenesis and can underly non-genetic drug resistance in cancer cells. Understanding the molecular biology of these processes and how they produce cellular outcomes is therefore important to understand both development and disease.
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Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Fellowship Rutherford-Crick Fellowship, UK Department for Business, Energy & Industrial Strategy (BEIS) Francis Crick Institute United Kingdom - -
Education
Date Institution name Country Title 2009 - 2016 University of Adelaide Australia PhD -
Postgraduate Training
Date Title Institution Country 2017 - 2023 Postdoctoral Researcher Francis Crick Institute United Kingdom 2017 - 2017 Postdoctoral Training Fellow MRC London Institute of Medical Sciences United Kingdom 2016 - 2016 Postdoctoral Research Associate University of Adelaide Australia
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Journals
Year Citation 2023 Sullivan, A. E. (2023). Epigenetic Control of Cell Potency and Fate Determination during Mammalian Gastrulation. Genes, 14(6), 16 pages.
2023 Sullivan, A. E., & Santos, S. D. (2023). The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis. Current Opinion in Genetics and Development, 82, 11 pages.
2022 Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity.
2021 Hellewell, J., Russell, T. W., Matthews, R., Severn, A., Adam, S., Enfield, L., . . . Gigli, C. C. (2021). Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections. BMC Medicine, 19(1), 10 pages.
Scopus67 Europe PMC762021 Balestrini, S., Koepp, M. J., Gandhi, S., Rickman, H. M., Shin, G. Y., Houlihan, C. F., . . . Goldstone, R. (2021). Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy. Epilepsy and Behavior, 115, 1-10.
Scopus9 Europe PMC72021 Hao, N., Sullivan, A. E., Shearwin, K. E., & Dodd, I. B. (2021). The loopometer: a quantitative in vivo assay for DNA-looping proteins. Nucleic Acids Research, 49(7), 1-16.
Scopus5 WoS5 Europe PMC42020 Houlihan, C. F., Vora, N., Byrne, T., Lewer, D., Kelly, G., Heaney, J., . . . Gutierrez, M. G. (2020). Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers. The Lancet, 396(10246), e6-e7.
Scopus148 WoS131 Europe PMC1232020 Aitken, J., Ambrose, K., Barrell, S., Beale, R., Bineva-Todd, G., Biswas, D., . . . Bowker, F. (2020). Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center (Nature Biotechnology, (2020), 38, 8, (927-931), 10.1038/s41587-020-0588-y). Nature Biotechnology, 38(8), 1000.
Europe PMC22020 Aitken, J., Ambrose, K., Barrell, S., Beale, R., Bineva-Todd, G., Biswas, D., . . . Broncel, M. (2020). Scalable and robust SARS-CoV-2 testing in an academic center. Nature Biotechnology, 38(8), 927-931.
Scopus24 WoS17 Europe PMC232020 Gunne-Braden, A., Sullivan, A., Gharibi, B., Sheriff, R. S. M., Maity, A., Wang, Y. F., . . . Santos, S. D. M. (2020). GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Cell Stem Cell, 26(5), 693-706.e9.
Scopus34 WoS31 Europe PMC222020 Sullivan, A. E., & Santos, S. D. M. (2020). An Optimized Protocol for ChIP-Seq from Human Embryonic Stem Cell Cultures. STAR Protocols, 1(2), 20 pages.
Scopus9 WoS3 Europe PMC92020 Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., . . . Atwal, P. S. (2020). Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.. J Clin Endocrinol Metab, 105(1), 355-361.
Scopus10 WoS6 Europe PMC62017 Moir, L., Bochukova, E. G., Dumbell, R., Banks, G., Bains, R. S., Nolan, P. M., . . . Cox, R. D. (2017). Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Molecular Metabolism, 6(11), 1419-1428.
Scopus12 WoS8 Europe PMC72016 Sullivan, A., Peet, D., & Whitelaw, M. (2016). MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS Journal, 283(18), 3488-3502.
Scopus10 WoS10 Europe PMC102015 Bersten, D., Sullivan, A., Li, D., Bhakti, V., Bent, S., & Whitelaw, M. (2015). Inducible and reversible lentiviral and recombination mediated cassette exchange (RMCE) systems for controlling gene expression. PLoS One, 10(3), e0116373-1-e0116373-20.
Scopus4 WoS3 Europe PMC32014 Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
Scopus9 WoS8 Europe PMC82013 Bersten, D., Sullivan, A., Peet, D., & Whitelaw, M. (2013). BHLH-PAS proteins in cancer. Nature Reviews. Cancer, 13(12), 827-841.
Scopus186 WoS159 Europe PMC1472013 Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
Scopus118 WoS98 Europe PMC832013 Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., . . . Farooqi, I. S. (2013). Erratum: Rare variants in single-minded 1 (SIM1) are associated with severe obesity (Journal of Clinical Investigation (2013) 123:7 (3042-3050) DOI: 10.1172/JCI68016). Journal of Clinical Investigation, 123(8), 3635.
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