Prof Simon Barry

University Professorial Research Fellow (E)

School of Biomedicine

Faculty of Health and Medical Sciences


Professor Simon C BarryI have developed a collaborative research program in the discipline of Paediatrics which has both a basic science and a translational component. This allows me to undertake gene discovery and functional validation in vitro and then access human clinical material to determine whether there is a causal link with disease. I run a grant funded research group within the Robinson Research Institute, and. I currently have a group of 5 staff and 3 students working on three projects.

I have developed a collaborative research program in the discipline of Paediatrics which has both a basic science and a translational component. This allows me to undertake gene discovery and functional validation in vitro and then access human clinical material to determine whether there is a causal link with disease.  I run a grant funded research group within the Robinson Research Institute, and. I currently have a group of 5 staff and 3 students working on three projects.  

Basic research

My background in molecular biology and gene discovery while working at Immunex in Seattle lead me to use unbiased genome wide discovery platforms as a way to identify the key genes and pathways in a cell, and I have had a long standing interest in transcriptional regulation and how gene networks collaborate to shape a phenotype. I have applied this to the field of molecular immunology, and to the transcription factor FOXP3 in particular. FOXP3 is essential for the formation and function of regulatory T cells (Tregs), and without Treg, a fatal aggressive autoimmune disease occurs (known as IPEX in man, and SCURFY in mouse). Treg are the policemen of the immune system and are responsible for maintaining tolerance to health, and for maintaining immune homeostasis. The lack of Treg or Treg function is now accepted as part of the cause of many autoimmune diseases, including Type 1 diabetes, IBD, rheumatoid arthritis and multiple sclerosis, and hence Treg play a significant part in maintaining health. With consecutive funding from 3 NHMRC project grants, I have been able to use genome wide approaches to discover the key targets of FOXP3 in human Treg, and to validate their biological importance in vitro and in vivo. My group was the first in the world to achieve this for human FOXP3 and we discovered a key target of FOXP3, SATB1 which is regulated to maintain Treg function. This is an international collaboration, and is productivity is demonstrated by a new NHMRC grant in 2012 and a paper in Nature Immunology. I have also taken advantage of the new finding that FOXP3 may act as a tumour suppressor in human beast epithelia, and we have used our FOXP3 target discovery to uncover novel mechanisms by which FOXP3 may act as such a tumour suppressor. This project began as an honours project, grew to a Ph.D project, and received NHMRC project funding for 2012-15. We are also investigating the role of microRNAs in the regulation of the Treg gene network, and this has lead to a new collaboration on the role of miRs in reproduction and 2 NHMRC grants with Prof Sarah Robertson.

Translational Research

I also led a project team in the $68 million CRC for Biomarker Translation, which aims to discover novel Treg surface proteins with commercial partners BD and AMGEN. I bring novel surface protein candidates to this CRC from my NHMRC funded basic science project. The commercialisation process for these novel surface markers is underway, with two full US, Europe and Australia patents awarded to protect a novel cell surface biomarker of human regulatory T cells, and a cell therapy to treat diseases with a Treg defect. This project is now at the stage where we seek a commercial partner to undertake a pilot clinical trial and translate my research findings to commercial applications.

Most recently I was invited to join and lead a theme in a new CRC for cell therapy manufacturing, and this was awarded $53 million in Jan 2013. This CRC will further aid my commercialisation and translational research program by developing methods to generate a cell therapy at lower cost of goods. We have filed 2 patents from the work in this CRC, and have now launched a small Biotech start-up (Carina Biotech) to commercialise human T cell expansion technologies, and apply them for human clinical trials. This will make A Treg and CAR-T cell therapy feasible in the future, and will make it affordable for healthcare systems and for commercial applications

Date Position Institution name
2017 - ongoing Professor Robinson Research Institute
2010 - ongoing Chief Hospital Scientist WCHN
2004 - 2017 Associate Professor Robinson Research Insitute, University of Adelaide

Date Institution name Country Title
1987 - 1991 National Institute for Medical Research United Kingdom Ph.D
1983 - 1987 King's College London United Kingdom B.Sc (hons)

Year Citation
2025 Harrison, L. C., Allnutt, T. R., Hanieh, S., Roth-Schulze, A. J., Ngui, K. M., Stone, N. L., . . . Ashwood, P. (2025). Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization. Nature Communications, 16(1), 15 pages.
DOI
2025 Wang, W., Lokman, N. A., Barry, S. C., Oehler, M. K., & Ricciardelli, C. (2025). LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance.. Cancer and Metastasis Reviews, 44(1), 23-1-23-23.
DOI Scopus9 WoS8 Europe PMC7
2025 Walker, G. J., Mallitt, K. -A., Craig, M. E., Ashwood, P., Barry, S. C., Brown, J. D., . . . ENDIA Study Group. (2025). SARS-CoV-2 Infection and Childhood Islet Autoimmunity. JAMA Pediatrics, 179(5), 568-570.
DOI Scopus3 WoS2 Europe PMC2
2025 Perkins, G. B., Tunbridge, M. J., Chai, C. S., Hope, C. M., Lip Yeow, A. E., Salehi, T., . . . Coates, P. T. (2025). mTOR Inhibitors and Vaccine Response in Kidney Transplant Recipients.. J Am Soc Nephrol, 36(11), 2213-2227.
DOI Scopus1 WoS1 Europe PMC1
2025 Köhne, M., Shakiba, M. H., Schmidleithner, L., Schulte-Schrepping, J., Scholz, R., Elmzzahi, T., . . . Beyer, M. D. (2025). Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression. Cell Reports, 44(7), 115866.
DOI Scopus1 WoS1 Europe PMC1
2024 Bandara, V., Niktaras, V. M., Willett, V. J., Chapman, H., Lokman, N. A., Macpherson, A. M., . . . Ricciardelli, C. (2024). Engineered CAR-T cells targeting the non‐functional P2X purinoceptor 7 (P2X7) receptor as a novel treatment for ovarian cancer. Clinical & Translational Immunology, 13(5), e1512-1-e1512-17.
DOI Scopus7 WoS7 Europe PMC6
2024 Thomson, R. L., Oakey, H., Haynes, A., Craig, M. E., Harrison, L. C., Wentworth, J. M., . . . Couper, J. J. (2024). Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information. BMJ Open Diabetes Research & Care, 12(4), e004130-1-e004130-13.
DOI Scopus5 WoS5 Europe PMC5
2024 Nicolas-Martinez, E. C., Robinson, O., Pflueger, C., Gardner, A., Corbett, M. A., Ritchie, T., . . . Jolly, L. A. (2024). RNA variant assessment using transactivation and transdifferentiation. American Journal of Human Genetics, 111(8), 1673-1699.
DOI Scopus7 WoS9 Europe PMC9
2024 Haynes, A., Tully, A., Smith, G. J., Penno, M. A. S., Craig, M. E., Wentworth, J. M., . . . ENDIA Study Group. (2024). Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes.. Diabetes care, 47(10), 1750-1756.
DOI Scopus10 WoS8 Europe PMC8
2024 Brewer, K., Wignall, A., Bazeed, A., Gundsambuu, B., Kohlhagen, J., Yan, J., . . . Blencowe, A. (2024). Customizable and Open-Source 3D Printed Inserts for Controlled Release and Cell Culture Experiments. ACS Applied Polymer Materials, 6(19), 11813-11827.
DOI
2024 Feizi, S., Awad, M., Ramezanpour, M., Cooksley, C., Murphy, W., Prestidge, C. A., . . . Vreugde, S. (2024). Promoting the Efficacy of Deferiprone-Gallium-Protoporphyrin (IX) against <i>Mycobacterium abscessus</i> Intracellular Infection with Lipid Liquid Crystalline Nanoparticles.. ACS applied materials & interfaces, 16(51), 70274-70283.
DOI Scopus1 WoS1 Europe PMC1
2024 Moldenhauer, L. M., Foyle, K. L., Wilson, J. J., Wong, Y. Y., Sharkey, D. J., Green, E. S., . . . Robertson, S. A. (2024). A disrupted FOXP3 transcriptional signature underpins systemic regulatory T cell insufficiency in early pregnancy failure. iScience, 27(2), 108994-1-108994-23.
DOI Scopus7 WoS6 Europe PMC6
2023 Harrison, L. C., Bandala-Sanchez, E., Oakey, H., Colman, P. G., Watson, K., Kim, K. W., . . . ENDIA Study Group. (2023). A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes. Journal of Diabetes Investigation, 14(9), 1092-1100.
DOI
2023 Zammit, N. W., Wong, Y. Y., Walters, S. N., Warren, J., Barry, S. C., & Grey, S. T. (2023). RELA governs a network of islet-specific metabolic genes necessary for beta cell function. Diabetologia, 66(8), 1516-1531.
DOI Scopus10 WoS10 Europe PMC9
2023 Perveen, K., Quach, A., Stark, M. J., Prescott, S., Barry, S. C., Hii, C. S., & Ferrante, A. (2023). PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity.. Immunology, 170(3), 359-373.
DOI Scopus3 WoS2 Europe PMC2
2023 Baßler, K., Schmidleithner, L., Shakiba, M. H., Elmzzahi, T., Köhne, M., Floess, S., . . . Beyer, M. (2023). Identification of the novel FOXP3-dependent T<inf>reg</inf> cell transcription factor MEOX1 by high-dimensional analysis of human CD4<sup>+</sup> T cells. Frontiers in Immunology, 14, 1107397.
DOI Scopus2 WoS2 Europe PMC2
2023 Bandara, V., Foeng, J., Gundsambuu, B., Norton, T. S., Napoli, S., McPeake, D. J., . . . Barry, S. C. (2023). Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7.. Nat Commun, 14(1), 1-17.
DOI Scopus20 WoS21 Europe PMC18
2023 Oakey, H., Giles, L. C., Thomson, R. L., Le Cao, K. -A., Ashwood, P., Brown, J. D., . . . ENDIA, S. G. (2023). Protocol for a nested case- control study design for omics investigations in the environmental determinants of islet autoimmunity cohort (vol 55, 2198255, 2023). ANNALS OF MEDICINE, 55(1), 1 page.
DOI
2023 Dinh, D. T., Breen, J., Nicol, B., Foot, N. J., Bersten, D. C., Emery, A., . . . Russell, D. L. (2023). Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling.. Nucleic Acids Research, 51(12), 5981-5996.
DOI Scopus16 WoS16 Europe PMC20
2023 Chen, Y., Mach, M., Shokouhi, A. R., Yoh, H. Z., Bishop, D. C., Murayama, T., . . . Voelcker, N. H. (2023). Efficient non-viral CAR-T cell generation via silicon-nanotube-mediated transfection. Materials Today, 63, 8-17.
DOI Scopus36 WoS33
2023 Wong, Y. Y., Harbison, J. E., Hope, C. M., Gundsambuu, B., Brown, K. A., Wong, S. W., . . . Barry, S. C. (2023). Parallel recovery of chromatin accessibility and gene expression dynamics from frozen human regulatory T cells. Scientific reports, 13(1), 5506-1-5506-15.
DOI Scopus8 WoS8 Europe PMC11
2023 Oakey, H., Giles, L. C., Thomson, R. L., Lê Cao, K. -A., Ashwood, P., Brown, J. D., . . . ENDIA Study Group. (2023). Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort. Annals of Medicine, 55(1), 1-14.
DOI Scopus7 WoS8 Europe PMC7
2022 Elsemary, M. T., Maritz, M. F., Smith, L. E., Warkiani, M., Bandara, V., Napoli, S., . . . Thierry, B. (2022). Inertial microfluidic purification of CAR-T-Cell products. Advanced Biology, 6(1), 12 pages.
DOI Scopus8 WoS7 Europe PMC2
2022 Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., . . . Lynn, D. J. (2022). Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection. BMC Medicine, 20(1), 26-1-26-23.
DOI Scopus206 WoS199 Europe PMC197
2022 Bandala-Sanchez, E., Roth-Schulze, A. J., Oakey, H., Penno, M. A. S., Bediaga, N. G., Naselli, G., . . . ENDIA Study Group. (2022). Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation.. Diabetes research and clinical practice, 184, 1-23.
DOI Scopus11 WoS11 Europe PMC11
2022 Hall, M., Oakey, H., Penno, M. A. S., McGorm, K., Anderson, A. J., Ashwood, P., . . . Cavenett, L. (2022). Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study. Diabetes Care, 45(5), 1082-1090.
DOI Scopus3 WoS3 Europe PMC5
2022 Perkins, G. B., Tunbridge, M., Salehi, T., Chai, C. S., Kireta, S., Johnston, J., . . . Coates, P. T. (2022). Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19. Kidney International, 101(5), 1077-1080.
DOI Scopus11 WoS10 Europe PMC10
2022 Yan, J., Gundsambuu, B., Krasowska, M., Platts, K., Facal Marina, P., Gerber, C., . . . Blencowe, A. (2022). Injectable Diels-Alder cycloaddition hydrogels with tuneable gelation, stiffness and degradation for the sustained release of T-lymphocytes.. Journal of materials chemistry. B, 10(17), 3329-3343.
DOI Scopus21 WoS22 Europe PMC15
2022 Garcia-Valtanen, P., Hope, C. M., Masavuli, M. G., Yeow, A. E. L., Balachandran, H., Mekonnen, Z. A., . . . Grubor-Bauk., B. (2022). SARS-CoV-2 Omicron variant escapes neutralising antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.. Cell Reports Medicine, 3(6), 100651-1-100651-17.
DOI Scopus34 WoS33 Europe PMC30
2022 Liu, N., Sadlon, T., Wong, Y. Y., Pederson, S., Breen, J., & Barry, S. C. (2022). 3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk. Epigenetics and Chromatin, 15(1), 1-21.
DOI Scopus3 WoS3 Europe PMC4
2022 Tunbridge, M., Perkins, G. B., Singer, J., Salehi, T., Ying, T., Grubor-Bauk, B., . . . Coates, P. T. (2022). Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)-rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipients.. Trials, 23(1), 780-1-780-12.
DOI Scopus7 WoS7 Europe PMC5
2021 Garcia-Valtanen, P., Hope, C. M., Masavuli, M. G., Yeow, A. E. L., Balachandran, H., Mekonnen, Z. A., . . . Grubor-Bauk, B. (2021). COVID-19 convalescents exhibit deficient humoral and T cell responses to variant of concern Spike antigens at 12 month post-infection.
DOI
2021 Perveen, K., Quach, A., Stark, M. J., Prescott, S. L., Barry, S. C., Hii, C. S., & Ferrante, A. (2021). Characterization of the transient deficiency of PKC isozyme levels in immature cord blood T cells and its connection to anti-allergic cytokine profiles of the matured cells. International Journal of Molecular Sciences, 22(23), 12650-1-12650-16.
DOI Scopus10 WoS9 Europe PMC8
2021 Hope, C. M., Huynh, D., Wong, Y. Y., Oakey, H., Perkins, G. B., Nguyen, T., . . . Barry, S. C. (2021). Optimization of blood handling and peripheral blood mononuclear cell cryopreservation of low cell number samples. International Journal of Molecular Sciences, 22(17), 9129-1-9129-19.
DOI Scopus22 WoS20 Europe PMC19
2021 Liu, N., Low, W. Y., Alinejad-Rokny, H., Pederson, S., Sadlon, T., Barry, S., & Breen, J. (2021). Seeing the forest through the trees: prioritising potentially functional interactions from Hi-C. Epigenetics & chromatin, 14(1), 1-17.
DOI Scopus8 WoS8 Europe PMC11
2021 Perveen, K., Quach, A., McPhee, A., Prescott, S. L., Barry, S. C., Hii, C. S., & Ferrante, A. (2021). Cord blood T cells expressing high and low PKCζ levels develop into cells with a propensity to display Th1 and Th9 cytokine profiles, respectively. International Journal of Molecular Sciences, 22(9), 1-16.
DOI Scopus9 WoS9 Europe PMC8
2021 Penno, M. A., Anderson, A. J., Thomson, R. L., McGorm, K., Barry, S. C., Colman, P. G., . . . ENDIA Study Group. (2021). Evaluation of protocol amendments to the Environmental Determinants of Islet Autoimmunity (ENDIA) study during the COVID-19 pandemic. Diabetic Medicine, 38(11), e14638-1-e14638-4.
DOI Scopus3 WoS2 Europe PMC3
2021 Roth-Schulze, A. J., Penno, M. A. S., Ngui, K. M., Oakey, H., Bandala-Sanchez, E., Smith, A. D., . . . Harrison, L. C. (2021). Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome. Microbiome, 9(1), 167-1-167-21.
DOI Scopus31 WoS28 Europe PMC28
2021 Harbison, J. E., Thomson, R. L., Wentworth, J. M., Louise, J., Roth‐Schulze, A., Battersby, R. J., . . . Couper, J. J. (2021). Associations between diet, the gut microbiome and short chain fatty acids in youth with islet autoimmunity and type 1 diabetes. Pediatric Diabetes, 22(3), 425-433.
DOI Scopus9 WoS8 Europe PMC8
2020 Macpherson, A. M., Barry, S. C., Ricciardelli, C., & Oehler, M. K. (2020). Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy.. J Clin Med, 9(9), 1-57.
DOI Scopus36 WoS34 Europe PMC29
2020 Brown, C. Y., Sadlon, T., Hope, C. M., Wong, Y. Y., Wong, S., Liu, N., . . . Barry, S. C. (2020). Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease. Frontiers in Immunology, 11(September), 1-17.
DOI Scopus15 WoS16 Europe PMC14
2020 Liu, N., Sadlon, T., Wong, Y. Y., Pederson, S., Breen, J., & Barry, S. C. (2020). 3DFAACTS-SNP: Using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of Type-1 Diabetes (T1D) risk. biorxiv.
DOI Europe PMC1
2020 Kim, J., Hope, C. M., Perkins, G. B., Stead, S. O., Scaffidi, J. C., Kette, F. D., . . . Coates, P. T. (2020). Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells. Clinical & Translational Immunology, 9(12), 1-20.
DOI Scopus9 WoS9 Europe PMC7
2020 Augustine, P., Gent, R., Louise, J., Taranto, M., Penno, M., Linke, R., . . . ENDIA Study Group. (2020). Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes. Diabetic Medicine, 37(8), 1340-1343.
DOI Scopus22 WoS19 Europe PMC19
2020 Schjenken, J. E., Moldenhauer, L. M., Zhang, B., Care, A. S., Groome, H. M., Chan, H. Y., . . . Robertson, S. A. (2020). MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice. Mucosal Immunology, 13(4), 609-625.
DOI Scopus40 WoS38 Europe PMC32
2020 Brewer, K., Gundsambuu, B., Facal Marina, P., Barry, S. C., & Blencowe, A. (2020). Thermoresponsive Poly(ε-Caprolactone)-Poly(Ethylene/Propylene Glycol) Copolymers as Injectable Hydrogels for Cell Therapies.. Polymers, 12(2), 1-19.
DOI Scopus28 WoS27 Europe PMC15
2020 Kim, J., Hope, C. M., Gantumur, N., Perkins, G. B., Stead, S. O., Yue, Z., . . . Coates, P. T. (2020). Encapsulation of human natural and induced regulatory T-cells in IL-2 and CCL1 supplemented alginate-GelMA hydrogel for 3D bioprinting. Advanced Functional Materials, 30(15), 2000544-1-2000544-17.
DOI Scopus42 WoS35
2020 Atashgaran, V., Dasari, P., Hodson, L. J., Evdokiou, A., Barry, S. C., & Ingman, W. V. (2020). Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice. Reproduction Fertility and Development, 32(8), 774-782.
DOI
2020 Penno, M. A., Oakey, H., Augustine, P., Taranto, M., Barry, S. C., Colman, P. G., . . . Couper, J. J. (2020). Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study. Pediatric Diabetes, 21(6), 945-949.
DOI Scopus11 WoS10 Europe PMC10
2019 Hope, C. M., Welch, J., Mohandas, A., Pederson, S., Hill, D., Gundsambuu, B., . . . Barry, S. C. (2019). Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes. European Journal of Immunology, 49(8), 1235-1250.
DOI Scopus21 WoS21 Europe PMC21
2019 Perveen, K., Quach, A., McPhee, A., Prescott, S. L., Barry, S. C., Hii, C. S., & Ferrante, A. (2019). Validation of monoclonal anti-PKC isozyme antibodies for flow cytometry analyses in human T cell subsets and expression in cord blood T cells. Scientific reports, 9(1), 9263-1-9263-11.
DOI Scopus9 WoS8 Europe PMC9
2019 Moldenhauer, L. M., Schjenken, J. E., Hope, C. M., Green, E. S., Zhang, B., Eldi, P., . . . Robertson, S. A. (2019). Thymus-derived regulatory T cells exhibit Foxp3 epigenetic modification and phenotype attenuation after mating in mice. Journal of Immunology, 203(3), 647-657.
DOI Scopus34 WoS32 Europe PMC33
2019 Wook Kim, K., Allen, D. W., Briese, T., Couper, J. J., Barry, S. C., Colman, P. G., . . . ENDIA Study Group. (2019). Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study. Open forum infectious diseases, 6(2), 1-8.
DOI Scopus42 WoS39 Europe PMC31
2019 Robertson, S. A., Green, E. S., Care, A. S., Moldenhauer, L. M., Prins, J. R., Hull, M. L., . . . Dekker, G. (2019). Therapeutic potential of regulatory T cells in preeclampsia-opportunities and challenges. Frontiers in Immunology, 10(MAR), 478-1-478-18.
DOI Scopus75 WoS68 Europe PMC63
2019 Schmidleithner, L., Thabet, Y., Schönfeld, E., Köhne, M., Sommer, D., Abdullah, Z., . . . Beyer, M. (2019). Enzymatic activity of HPGD in Treg cells Suppresses Tconv cells to maintain adipose tissue homeostasis and prevent metabolic dysfunction. Immunity, 50(5), 1232-1248.e14.
DOI Scopus84 WoS80 Europe PMC77
2019 Harbison, J. E., Roth-Schulze, A. J., Giles, L. C., Tran, C. D., Ngui, K. M., Penno, M. A., . . . Couper, J. J. (2019). Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: a prospective cohort study. Pediatric Diabetes, 20(5), 574-583.
DOI Scopus123 WoS107 Europe PMC103
2019 Kim, K. W., Allen, D. W., Briese, T., Couper, J. J., Barry, S. C., Colman, P. G., . . . ENDIA STUDY GROUP. (2019). Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes. Pediatric Diabetes, 21(2), 271-279.
DOI Scopus12 WoS10 Europe PMC12
2019 Hayes, K. R., Inglis, G. J., & Barry, S. C. (2019). The Assessment and Management of Marine Pest Risks Posed by Shipping: The Australian and New Zealand Experience. FRONTIERS IN MARINE SCIENCE, 6, 13 pages.
DOI WoS16
2018 Penington, J. S., Penno, M., Ngui, K., Ajami, N., Roth-Schulze, A., Wilcox, S., . . . Giles, L. (2018). Influence of fecal collection conditions and 16S rRNA gene sequencing protocols at two centers on human gut microbiota analysis. Scientific Reports, 8, 10 pages.
DOI
2018 Sadlon, T., Brown, C. Y., Bandara, V., Hope, C. M., Schjenken, J. E., Pederson, S. M., . . . Barry, S. C. (2018). Unravelling the molecular basis for regulatory T-cell plasticity and loss of function in disease. Clinical and Translational Immunology, 7(2), e1011-1-e1011-15.
DOI Scopus27 WoS23 Europe PMC21
2018 Penington, J., Penno, M., Ngui, K., Ajami, N., Roth-Schulze, A., Wilcox, S., . . . Vuillermin, P. (2018). Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis. Scientific Reports, 8(1), 4386-1-4386-10.
DOI Scopus45 WoS44 Europe PMC41
2018 Brown, C. Y., Dayan, S., Wong, S. W., Kaczmarek, A. K., Hope, C. M., Pederson, S. M., . . . Barry, S. C. (2018). FOXP3 and miR-155 cooperate to control the invasive potential of human breast cancer cells by down regulating ZEB2 independently of ZEB1. Oncotarget, 9(45), 27708-27727.
DOI Scopus20 Europe PMC18
2017 Worton, L., Shi, Y. -C., Smith, E., Barry, S., Gonda, T., Whitehead, J., & Gardiner, E. (2017). Ectodermal-neural cortex 1 isoforms have contrasting effects on MC3T3-E1 osteoblast mineralization and gene expression. Journal of Cellular Biochemistry, 118(8), 2141-2150.
DOI Scopus7 WoS7 Europe PMC8
2017 Phillips, J., Couper, J., Penno, M., & Harrison, L. (2017). Type 1 diabetes: a disease of developmental origins. Pediatric Diabetes, 18(6), 417-421.
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2017 Robertson, S., Zhang, B., Chan, H., Sharkey, D., Barry, S., Fullston, T., & Schjenken, J. (2017). MicroRNA regulation of immune events at conception. Molecular Reproduction and Development, 84(9), 914-925.
DOI Scopus25 WoS24 Europe PMC22
2017 Hinze, S., Jackson, M., Lie, S., Jolly, L., Field, M., Barry, S., . . . Shoubridge, C. (2017). Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis. Translational Psychiatry, 7(5), e1110-1-e-1110-11.
DOI Scopus35 WoS36 Europe PMC30
2017 Delalat, B., Harding, F., Gundsambuu, B., De-Juan-Pardo, E., Wunner, F., Wille, M., . . . Barry, S. (2017). 3D printed lattices as an activation and expansion platform for T cell therapy. Biomaterials, 140, 58-68.
DOI Scopus36 WoS33 Europe PMC22
2017 Ivask, A., Mitchell, A., Hope, C., Barry, S., Lombi, E., & Voelcker, N. (2017). Single cell level quantification of nanoparticle-cell interactions using mass cytometry. Analytical Chemistry, 89(16), 8228-8232.
DOI Scopus37 WoS32 Europe PMC21
2017 Maartens, J., De-Juan-Pardo, E., Wunner, F., Simula, A., Voelcker, N., Barry, S., & Hutmacher, D. (2017). Challenges and opportunities in the manufacture and expansion of cells for therapy. Expert Opinion on Biological Therapy, 17(10), 1221-1233.
DOI Scopus18 WoS15 Europe PMC15
2016 Atashgaran, V., Wrin, J., Barry, S., Dasari, P., & Ingman, W. (2016). Dissecting the biology of menstrual cycle-associated breast cancer risk. Frontiers in Oncology, 6(DEC), 1-10.
DOI Scopus52 WoS49 Europe PMC43
2016 Thomas, C., Forrest, A., Klingberg, H., Moore, D., Abu-Assi, R., Barry, S. C., & Khurana, S. (2016). Does Gastrostomy Placement With Concurrent Fundoplication Increase the Risk of Gastrostomy-related Complications?. Journal of Pediatric Gastroenterology and Nutrition, 63(1), 29-33.
DOI Scopus5 WoS7 Europe PMC6
2015 Jolly, L., Nguyen, L., Domingo, D., Sun, Y., Barry, S., Hancarova, M., . . . Gecz, J. (2015). HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain.. Human Molecular Genetics, 24(12), 3335-3347.
DOI Scopus42 WoS43 Europe PMC50
2015 Prins, J., Zhang, B., Schjenken, J., Guerin, L., Barry, S., & Robertson, S. (2015). Unstable Foxp3p⁺ regulatory T cells and altered dendritic cells are associated with lipopolysaccharide-induced fetal loss in pregnant interleukin 10-deficient mice. Biology of Reproduction, 93(4), 95-1-95-14.
DOI Scopus37 WoS33 Europe PMC29
2015 Caley, P., Ramsey, D. S. L., & Barry, S. C. (2015). Inferring the Distribution and Demography of an Invasive Species from Sighting Data: The Red Fox Incursion into Tasmania. PLOS ONE, 10(1), 18 pages.
DOI WoS18
2014 Caley, P., & Barry, S. C. (2014). Quantifying Extinction Probabilities from Sighting Records: Inference and Uncertainties. PLOS ONE, 9(4), 11 pages.
DOI WoS20
2014 Prins, J. R., Guerin, L. R., Zhang, B., Schjenken, J. E., Barry, S. C., & Robertson, S. A. (2014). Interleukin-10 deficiency causes dysregulation of the regulatory T cell response to pregnancy in mice. Reproductive Sciences, 21(3 Suppl.), 99A.
DOI
2013 Jolly, L., Homan, C., Jacob, R., Barry, S., & Gecz, J. (2013). The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. Human Molecular Genetics, 22(23), 4673-4687.
DOI Scopus108 WoS99 Europe PMC104
2013 Penno, M., Couper, J., Craig, M., Colman, P., Rawlinson, W., Cotterill, A., . . . Wentworth, J. (2013). Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatrics, 13(1), 1-15.
DOI Scopus73 WoS65 Europe PMC57
2012 Grose, R., Millard, D., Mavrangelos, C., Barry, S., Zola, H., Nicholson, I., . . . Krumbiegel, D. (2012). Comparison of blood and synovial fluid Th17 and novel peptidase inhibitor 16 Treg cell subsets in juvenile idiopathic arthritis. Journal of Rheumatology, 39(10), 2021-2031.
DOI Scopus12 WoS11 Europe PMC11
2012 Hill, D., Eastaff-Leung, N., Bresatz-Atkins, S., Warner, N., Ruitenberg, J., Krumbiegel, D., . . . Barry, S. (2012). Inhibition of activation induced CD154 on CD4⁺ CD25⁻ cells: a valid surrogate for human Treg suppressor function. Immunology and Cell Biology, 90(8), 812-821.
DOI Scopus13 WoS11 Europe PMC10
2012 Nicholson, I., Mavrangelos, C., Bird, D., Bresatz-Atkins, S., Eastaff-Leung, N., Grose, R., . . . Krumbiegel, D. (2012). PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cellular Immunology, 275(1), 12-18.
DOI Scopus23 WoS23 Europe PMC21
2012 McInnes, N., Sadlon, T., Brown, C., Pederson, S., Beyer, M., Schultze, J., . . . Barry, S. (2012). FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene, 31(8), 1045-1054.
DOI Scopus93 WoS85 Europe PMC75
2011 Skalamera, D., Ranall, M., Wilson, B., Leo, P., Purdon, A., Hyde, C., . . . Gonda, T. (2011). A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One, 6(5), e20057-1-e20057-14.
DOI Scopus41 WoS42 Europe PMC40
2011 Beyer, M., Sadlon, T., & Barry, S. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature Immunology, 12(9), 898-907.
DOI Scopus181 WoS179 Europe PMC164
2011 Roberts-Thomson, I., Fon, J., Uylaki, W., Cummins, A., & Barry, S. (2011). Cells, cytokines and inflammatory bowel disease: A clinical perspective. Expert Review of Gastroenterology and Hepatology, 5(6), 703-716.
DOI Scopus103 WoS92 Europe PMC80
2010 Eastaff-Leung, N., Mabarrack, N., Barbour, A., Cummins, A., & Barry, S. (2010). Foxp3⁺ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. Journal of Clinical Immunology, 30(1 Sp Iss), 80-89.
DOI Scopus356 WoS332 Europe PMC311
2010 Brown, C., Sadlon, T., Gargett, T., Melville, E., Zhang, R., Drabsch, Y., . . . Barry, S. (2010). Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector. Human Gene Therapy, 21(8), 1005-1017.
DOI Scopus27 WoS28 Europe PMC24
2010 Sadlon, T., Wilkinson, B., Pederson, S., Brown, C., Bresatz, S., Gargett, T., . . . Barry, S. (2010). Genome-wide identification of human FOXP3 target genes in natural regulatory T cells. Journal of Immunology, 185(2), 1071-1081.
DOI Scopus124 WoS122 Europe PMC112
2009 Li, S., Floess, S., Hamann, A., Gaudieri, S., Lucas, A., Hellard, M., . . . Gowans, E. (2009). Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathogens, 5(12), 1000707-1-1000707-13.
DOI Scopus30 WoS44 Europe PMC28
2009 Hutton, J., Gargett, T., Sadlon, T., Bresatz, S., Brown, C., Zola, H., . . . Barry, S. (2009). Development of CD4⁺CD25⁺FoxP3⁺ regulatory T cells from cord blood hematopoietic progenitor cells. Journal of Leukocyte Biology, 85(3), 445-451.
DOI Scopus29 WoS20 Europe PMC21
2008 Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., . . . Goodall, G. (2008). The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601.
DOI Scopus3457 WoS3254 Europe PMC2975
2008 Drabsch, Y., Hugo, H., Zhang, R., Dowhan, D. H., Miao, Y. R., Gewirtz, A. M., . . . Gonda, T. J. (2008). Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, (13762-13767) DOI: 10.1073/pnas.0700104104). Proceedings of the National Academy of Sciences of the United States of America, 105(2), 825.
DOI Scopus1 WoS1
2007 Brzezinski, M., Yanay, O., Waldron, L., Barry, S., & Osborne, W. (2007). G-CSF-lentivirus administration in rats provided sustained elevated neutrophil counts and subsequent EPO-lentivirus administration increased hematocrits. Journal of Gene Medicine, 9(7), 571-578.
DOI Scopus4 WoS4 Europe PMC4
2007 Bresatz, S., Sadlon, T., Millard, D., Zola, H., & Barry, S. (2007). Isolation, propagation and characterization of cord blood derived CD4+ CD25+ regulatory T cells. Journal of Immunological Methods, 327(1-2), 53-62.
DOI Scopus24 WoS22 Europe PMC21
2007 Drabsch, Y., Hugo, H., Zhang, R., Dowhan, D., Miao, Y., Gewirtz, A., . . . Gonda, T. (2007). Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 104(34), 13762-13767.
DOI Scopus114 WoS118 Europe PMC105
2007 Zola, H., Swart, B., Banham, A., Barry, S., Beare, A., Bensussan, A., . . . Yang, X. (2007). CD molecules 2006 - Human cell differentiation molecules. Journal of Immunological Methods, 319(1-2), 1-5.
DOI Scopus119 WoS91 Europe PMC84
2007 Barry, S., & Coates, P. (2007). Retroviral escape by Friendly infected DCs [Comment on Balkow et al, page 3949]. Blood, 110(12), 3819-3820.
DOI
2005 Barry, S., Brzezinski, M., Yanay, O., Seppen, J., & Osborne, W. (2005). Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery. Journal of Gene Medicine, 7(12), 1510-1516.
DOI Scopus3 WoS3 Europe PMC3
2003 Yanay, O., Barry, S., Flint, L., Brzezinski, M., Barton, R., & Osborne, W. (2003). Long-Term erythropoietin gene expression from transduced cells in bioisolator devices. Human Gene Therapy, 14(17), 1587-1593.
DOI Scopus20 WoS19 Europe PMC15
2003 Yanay, O., Barry, S., Katen, L., Brzezinski, M., Flint, L., Christensen, J., . . . Osborne, W. (2003). Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery. Blood, 102(6), 2046-2052.
DOI Scopus16 WoS13 Europe PMC11
2001 Barry, S., Harder, B., Brezezinski, M., Flint, L., Seppen, J., & Osborne, W. (2001). Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression. Human Gene Therapy, 12(9), 1103-1108.
DOI Scopus116 WoS116 Europe PMC109
2001 Barry, S., Ramesh, N., Lejnieks, D., Simonson, W., Kemper, L., Lernmark, A., & Osborne, W. (2001). Glucose-regulated insulin expression in diabetic rats. Human Gene Therapy, 12(2), 131-140.
DOI Scopus24 WoS22 Europe PMC18
2001 Seppen, J., Barry, S., Harder, B., & Osborne, W. (2001). Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin. Blood, 98(3), 594-596.
DOI Scopus52 WoS43 Europe PMC37
2001 Jones, K., Bagley, C., Butcher, C., Barry, S., Vadas, M., & D'Andrea, R. (2001). Peptide insertions in domain 4 of hbc, the shared signalling receptor subunit for GM-CSF, IL3 and IL5, induce ligand-independent activation. Cytokine, 14(6), 303-315.
DOI Scopus2 WoS2 Europe PMC1
2000 Seppen, J., Barry, S., Lam, G. M., Ramesh, N., & Osborne, W. R. A. (2000). Retroviral preparations derived from PA317 packaging cells contain inhibitors that copurify with viral particles and are devoid of viral vector RNA. Human Gene Therapy, 11(5), 771-775.
DOI Scopus14 WoS14 Europe PMC13
2000 Barry, S. C., Seppen, J., Ramesh, N., Foster, J. L., Seyama, K., Ochs, H. D., . . . Osborne, W. R. A. (2000). Lentiviral and murine retroviral transduction of T cells for expression of human CD40 ligand. Human Gene Therapy, 11(2), 323-332.
DOI Scopus25 WoS23 Europe PMC19
2000 Seppen, J., Barry, S. C., Klinkspoor, J. H., Katen, L. J., Lee, S. P., Garcia, J. V., & Osborne, W. R. A. (2000). Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors. Journal of Virology, 74(16), 7642-7645.
DOI Scopus37 WoS35 Europe PMC36
1997 Barry, S., Korpelainen, E., Sun, Q., Stomski, F., Moretti, P., Wakao, H., . . . Goodall, G. (1997). Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function.. Blood, 89(3), 842-852.
DOI Scopus54 WoS55 Europe PMC28
1996 Coulter, C., Read, L., Carr, B., Tarantal, A., Barry, S., & Styne, D. (1996). A role for EGF in the morphological and functional maturation of the adrenal gland in the fetal rhesus monkey in vivo. Journal of Clinical Endocrinology and Metabolism, 81(3), 1254-1260.
1996 D'Andrea, R. J., Barry, S. C., Moretti, P. A. B., Jones, K., Ellis, S., Vadas, M. A., & Goodall, G. J. (1996). Extracellular truncations of hβc, the common signaling subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5, lead to ligand-independent activation. Blood, 87(7), 2641-2648.
DOI Scopus25 WoS25 Europe PMC11
1994 Barry, S. C., Bagley, C. J., Phillips, J., Dottore, M., Cambareri, B., Moretti, P., . . . Lopez, A. F. (1994). Two contiguous residues in human interleukin-3, Asp 21 and Glu 22, selectively interact with the α- and β-chains of its receptor and participate in function. Journal of Biological Chemistry, 269(11), 8488-8492.
DOI Scopus76 WoS76 Europe PMC46
1994 BAGLEY, C. J., WOODCOCK, J. M., BARRY, S. C., PHILLIPS, J. A., DOTTORE, M., CAMBARERI, B., . . . LOPEZ, A. F. (1994). INTERACTION OF THE FIRST AND 4TH HELICES OF INTERLEUKIN-3 WITH THE ALPHA-CHAINS AND BETA-CHAINS OF ITS RECEPTOR. JOURNAL OF CELLULAR BIOCHEMISTRY, 17.
WoS1
1992 Lopez, A. F., Shannon, M. F., Barry, S., Phillips, J. A., Cambareri, B., Dottore, M., . . . Vadas, M. A. (1992). A human interleukin 3 analog with increased biological and binding activities. Proceedings of the National Academy of Sciences of the United States of America, 89(24), 11842-11846.
DOI Scopus45 WoS42 Europe PMC27
1991 McKenzie, A. N. J., Barry, S. C., Strath, M., & Sanderson, C. J. (1991). Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules. EMBO Journal, 10(5), 1193-1199.
DOI Scopus70 WoS61 Europe PMC46
1991 Barry, S. C., McKenzie, A. N. J., Strath, M., & Sanderson, C. J. (1991). Analysis of interleukin 5 receptors on murine eosinophils: A comparison with receptors on B13 cells. Cytokine, 3(4), 339-344.
DOI Scopus8 WoS8 Europe PMC3

Year Citation
2025 Perveen, K., Quach, A., Stark, M. J., Barry, S. C., Prescott, S. L., & Ferrante, A. (2025). Polyunsaturated fatty acids regulate protein kinase C zeta levels in immature (cord blood) T cells, their maturation towards a Th1 cytokine bias and its significance in reducing allergy risk. In JOURNAL OF IMMUNOLOGY Vol. 214 (pp. 1 page). OXFORD UNIV PRESS.
DOI
2024 Foeng, J., Tyllis, T., Abbott, C., McPeake, D., Thompson, E., Bandara, V., . . . McColl, S. (2024). Preclinical in vivo characterization underpinning LGR5-targeting CAR-T cells as a cancer immunotherapy. In CANCER RESEARCH Vol. 84 (pp. 2 pages). CA, San Diego: AMER ASSOC CANCER RESEARCH.
DOI
2023 Bandara, V., Gundsambuu, B., Napoli, S., Foeng, J., McPeake, D., Tylis, T., . . . Barry, S. (2023). From bench to bedside: GMP manufacturing and testing of an LGR5-targeting CAR-T against colorectal cancer. In CANCER RESEARCH Vol. 84 (pp. 2 pages). CA, San Diego: AMER ASSOC CANCER RESEARCH.
DOI WoS1
2023 Tyllis, T., Abbott, C., McPeake, D., Foeng, J., Bandara, V., Gundsambuu, B., . . . McColl, S. (2023). Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells. In CANCER RESEARCH Vol. 83 (pp. 2 pages). Orlando, FL: AMER ASSOC CANCER RESEARCH.
DOI
2023 Bandara, V., Gundsambuu, B., Napoli, S., Mills, S., Thompson, E., Tan, L., . . . Barry, S. C. (2023). Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer. In CANCER RESEARCH Vol. 83 (pp. 2 pages). Orlando, FL: AMER ASSOC CANCER RESEARCH.
DOI WoS1
2023 McPeake, D., Tyllis, T., Abbott, C., Foeng, J., Bandara, V., Gundsambuu, B., . . . McColl, S. (2023). In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer. In CANCER RESEARCH Vol. 83 (pp. 2 pages). Orlando, FL: AMER ASSOC CANCER RESEARCH.
DOI
2023 Thompson, E. J., Bandara, V., Gundsambuu, B., Napoli, S., Mills, S., Foeng, J., . . . Bonder, C. S. (2023). Assessing LGR5 expression levels on colorectal cancer tissue samples for use in LGR5-targeting CAR-T cell therapy clinical trial. In CANCER RESEARCH Vol. 83 (pp. 2 pages). Orlando, FL: AMER ASSOC CANCER RESEARCH.
DOI WoS1
2023 Desai, J., Iglesias, J. L., Jablonskis, L. T., McColl, S., Barry, S. C., & Morelli, M. P. (2023). A phase 1/2a, multicenter, open-label study of CNA3103 (LGR5-targeted, autologous CART cells) in patients with metastatic colorectal cancer (mCRC). In JOURNAL OF CLINICAL ONCOLOGY Vol. 41 (pp. 1 page). IL, Chicago: LIPPINCOTT WILLIAMS & WILKINS.
WoS3
2022 Rad, E. R., Foeng, J., McPeak, D., Tyllis, T., Abbott, C., Bandara, V., . . . McColl, S. (2022). ADAM10-targeting CAR-T cells inhibit colon cancer cell growth <i>in vivo</i>. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Wang, W., Bandara, V., Lokman, N., Napoli, S., Gundsambuu, B., Oehler, M., . . . Ricciardelli, C. (2022). LGR5 CAR-T cells: A novel potential treatment against high grade serous ovarian cancer.. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Bandara, V., Mills, S., Thompson, E., Tan, L., Gundsambuu, B., Napoli, S., . . . Barry, S. (2022). Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer.. In CANCER RESEARCH Vol. 82 (pp. 1 page). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Thompson, E. J., Bandara, V., Sadlon, T., Gundsambuu, B., Tan, L. Y., Ricciardelli, C., . . . Bonder, C. S. (2022). Real-time cytotoxicity assays as a pre-clinical screening tool for LGR5-targeting CAR-T cells for treatment of solid tumors. In CANCER RESEARCH Vol. 82 (pp. 1 page). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Thompson, E. J., Bandara, V., Sadlon, T., Gundsambuu, B., Tan, L. Y., Ricciardelli, C., . . . Bonder, C. S. (2022). Real-time cytotoxicity assays as a pre-clinical screening tool for LGR5-targeting CAR-T cells for treatment of solid tumors.. In CANCER RESEARCH Vol. 82 (pp. 1 page). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 McPeake, D. J., Tyllis, T. S., Foeng, J., Bandara, V., Abbott, C. A., Gundsambuu, B., . . . McColl, S. R. (2022). <i>In vivo</i> characterization of a novel CAR-T cell therapy directed towards LGR5 for the treatment of colorectal cancer.. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 McPeake, D. J., Tyllis, T. S., Foeng, J., Bandara, V., Abbott, C. A., Gundsambuu, B., . . . McColl, S. R. (2022). In <i>vivo</i> characterization of a novel CAR-T cell therapy directed towards LGR5 for the treatment of colorectal cancer. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Bandara, V., Mills, S., Thompson, E., Tan, L., Gundsambuu, B., Napoli, S., . . . Barry, S. (2022). Pre-clinical validation of a LGR5-targeting CAR-T against colorectal cancer. In CANCER RESEARCH Vol. 82 (pp. 1 page). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Wang, W., Bandara, V., Lokman, N., Napoli, S., Gundsambuu, B., Oehler, M., . . . Ricciardelli, C. (2022). LGR5 CAR-T cells: A novel potential treatment against high grade serous ovarian cancer. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Rad, E. R., Foeng, J., McPeak, D., Tyllis, T., Abbott, C., bandara, V., . . . McColl, S. (2022). ADAM10-targeting CAR-T cells inhibit colon cancer cell growth <i>in vivo</i>.. In CANCER RESEARCH Vol. 82 (pp. 2 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
2022 Tunbridge, M. J., Perkins, G., Salehi, T., Grubor-Bauk, B., Sim, B., Ying, T., . . . Coates, P. T. (2022). A Prospective Randomised, Controlled Trial Switching Sirolimus for Mycophenolate to Enhance Immunological Responses to Third Dose COVID-19 Vaccination in Kidney Transplant Recipients with Poor Baseline Humoral Immunity. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 22 (pp. 1095). ELECTR NETWORK: WILEY.
2022 Perkins, G. B., Tunbridge, M., Salehi, T., Chai, C., Hope, C. M., Garcia-Valtanen, P., . . . Coates, P. (2022). Sirolimus Use is Associated with an Improved Immune Response to COVID-19 Vaccination in Kidney Transplant Recipients. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 22 (pp. 873). WILEY.
2022 Perkins, G., Tunbridge, M., Salehi, T., Chai, C. S., Hope, C. M., Garcia-Valtanen, P., . . . Coates, A. O. T. (2022). MTOR Inhibitors Promote Highly Functional T Cell Immunity in Kidney Transplant Recipients Vaccinated Against COVID-19. In TRANSPLANTATION Vol. 106 (pp. S223). ELECTR NETWORK: LIPPINCOTT WILLIAMS & WILKINS.
2020 Kim, J., Hope, C. M., Scaffidi, J. C., Stead, S. O., Perkins, G. B., Kette, F. D., . . . Coates, P. T. (2020). GENERATION OF STABLE HUMAN INDUCED REGULATORY T-CELLS REQUIRES OPTIMAL RAPAMYCIN CONCENTRATION AND TCR STIMULATION. In TRANSPLANTATION Vol. 104 (pp. S206). ELECTR NETWORK: LIPPINCOTT WILLIAMS & WILKINS.
2018 Bird, T. G., Mueller, M., Boulter, L., Vincent, D., Ridgway, R., Lopez Guadamillas, E., . . . Forbes, S. J. (2018). Inhibiting Senescence Induced By Macrophage Derived Tgf beta Restores a Regenerative Response and Improves Survival Following Acetaminophen Poisoning. In HEPATOLOGY Vol. 68 (pp. 200A-201A). San Francisco, CA: WILEY.
2018 Harbison, J. E., Roth-Schulze, A. J., Barry, S. C., Tran, C. D., Ngui, K., Penno, M. A., . . . Couper, J. (2018). Gut Microbiome Dysbiosis and Increased Intestinal Permeability in Australian Children with Islet Autoimmunity and Type 1 Diabetes. In DIABETES Vol. 67 (pp. 2 pages). Orlando, FL: AMER DIABETES ASSOC.
DOI WoS2
2018 Robertson, S. A., Zhang, B., Barry, S. C., Schjenken, J. E., & Moldenhauer, L. M. (2018). miRNA-155 is required to induce competent regulatory T cells and to protect against inflammation-induced fetal loss in mice. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 36-37). Perth, AUSTRALIA: WILEY.
2018 Kim, J., Yue, Z., Liu, X., Hope, C., Rojas-Canales, D., Drogemuller, C., . . . Coates, P. T. (2018). Characterization of 3D-Printed Human Regulatory T-Cells. In TRANSPLANTATION Vol. 102 (pp. S109). Madrid, SPAIN: LIPPINCOTT WILLIAMS & WILKINS.
DOI
2017 Kim, K. W., Allen, D. W., Briese, T., Pang, C. N., Jain, K., Horton, J. L., . . . Craig, M. E. (2017). Gut Virome Dynamics during Pregnancy in Mothers with Type 1 Diabetes. In Abstracts of the 77th Scientific Sessions of the American Diabetes Association, as published in Diabetes Vol. 66 (pp. LB192). San Diego, CA: American Diabetes Association.
2016 Mohandas, A., Hill, D., Hope, C., Pederson, S., Walsh, J., Grose, R., . . . Barry, S. C. (2016). A new biomarker of stable regulatory T cell function which has diagnostic utility in type 1 diabetes. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 748). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2016 Malatesta, K., Sadlon, T., Pederson, S., Brown, C., & Barry, S. C. (2016). Validating the contribution of microRNAs and lncRNAs to the molecular signature and plasticity of iTreg vs. nTreg in humans. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1216). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2016 Brown, C., Beyer, M., Pederson, S., Goodall, G., Schultze, J., Sadlon, T., & Barry, S. C. (2016). FOXP3 tightly controls target gene expression using microRNAs in human regulatory T cells, and regulates Treg plasticity. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1216). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2016 Harding, F., Delalat, B., Guundsambuu, B., Pardo, E., Hutmacher, D., Voelcker, N., & Barry, S. C. (2016). A novel human T cell expansion technology for affordable cell therapy. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 747). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2015 Muhling, J., Russell, D., & Barry, S. (2015). USE OF VIRAL VECTORS IN PRIMARY CELLS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 214-215). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL.
2014 Mohandas, A., Zola, H., Barry, S., & Krumbiegel, D. (2014). Peptidase inhibitor 16 identifies a unique subset of memory T helper cells with hyperproliferative and proinflammatory properties. In JOURNAL OF IMMUNOLOGY Vol. 192 (pp. 1 page). AMER ASSOC IMMUNOLOGISTS.

Year Citation
2024 Wang, W. J., Bandara, V., Lokman, N. A., Price, Z. K. K., Noye, T. M., Napoli, S., . . . Ricciardelli, C. (2024). CAR-T cells targeting LGR5: An effective treatment for chemotherapy resistant ovarian cancer. Poster session presented at the meeting of Proceedings of the American Association for Cancer Research Annual Meeting (AACR, 2024) as published in Cancer Research. San Diego, California: American Association for Cancer Research.
DOI
2023 Robertson, S. A., Foyle, K. L., Moldenhauer, L. M., Wong, Y. Y., Green, E. S., Barry, S. C., & Hull, M. L. (2023). Lineage infidelity underpinningregulatory T cell deficiency in recurrent pregnancy loss. Poster session presented at the meeting of Abstracts of the XV World Congress of the International Society for Immunology of Reproduction (ISIR 2023), as published in Journal of Reproductive Immunology. Hamburg, Germny: Elsevier BV.
DOI
2023 Desai, J., Iglesias, J. L., Jablonskis, L. T., McColl, S., Barry, S. C., & Morelli, M. P. (2023). A phase 1/2a, multicenter, open-label study of CNA3103 (LGR5-targeted, autologous CAR-T cells) in patients with metastatic colorectal cancer (mCRC).. Poster session presented at the meeting of JOURNAL OF CLINICAL ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS.
DOI
2018 Lowe, K., Huan, D., Rebuli, M., Golley, S., Tran, C., & Barry, S. C. (2018). Is the dual sugar test of intestinal permeability diagnostic for determining altered barrier function?. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY.
2013 Bresatz, S., Ang, G., Eastaff-Leung, N., Hill, D., Pederson, S., Grose, R., . . . Barry, S. C. (2013). Novel FOXP3 surrogate biomarkers on human Treg. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Melbourne, Vic.: Wiley.
DOI

Year Citation
2014 Barry, S. (2014). 2408934, Peptidase Inhibitor 16(PI16) as a Biomarker for Regulatory T (TREG) Cells and Uses Thereof. Europe.

Year Citation
2018 Pederson, S. M. (2018). BMEA: Bayesian Modelling for Exon Array Data. (PhD Thesis, University of Adelaide).

Year Citation
2021 Ryan, F., Hope, C., Masavuli, M., Lynn, M., Mekonnen, Z., Lip Yeow, A. E., . . . Lynn, D. (2021). Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection.
DOI Europe PMC1

Summary of major funding

Since my arrival in Jan 2004, I have been successful in attracting over $3.2 million in research funding ($1,210,500 currently to my lab), including 5 NHMRC project grants as CIA, an NHMRC program grant as CID and an ARC linkage grant as CIA.  As a co senior applicant I am a CI on 2 NHMRC project grants, and 2 Cooperative Research Centre programs. In collaboration with a national team lead by Prof Couper I am a named chief investigator on the ENDIA study, a $10 million birth cohort study funded by the JDRF and Helmsley trust. In addition, I have attracted a number of small grants as CIA and a commercial partnership.  I am named CI on 4 NHMRC project applications under consideration in the current round. From 2006, my successful grant application rate is over 80%. This has allowed growth in staff in my group, and allowed a number of collaborations to be initiated, and these are now yielding high impact publications.

Barry Group Funding

Teaching

         Annual lecture delivery to year 3 Infection and Immunity course in the Bachelor of Science degree (Faculty of Science, School of Biological Sciences, Department of Molecular and Cellular Biology. This course is coordinated by Prof Shaun McColl, and is managed by Chris Wong and Jamie Botten. I have been delivering a research and training lecture to this course since 2006, and although I have not received SELT scores for my contribution to this, I have been invited to teach in this course for 8 years, and I have doubled the number of lectures I deliver since 2014.

Date Role Research Topic Program Degree Type Student Load Student Name
2023 Co-Supervisor Investigating the role of JAZF1 in the formation and function of human induced Regulatory T cells Doctor of Philosophy Doctorate Full Time Miss Hannah Rae Morgan
2023 Principal Supervisor Investigating regulatory T cells post COVID-19 Doctor of Philosophy Doctorate Full Time Ms Sarah May Battersby
2023 Principal Supervisor Investigating regulatory T cells post COVID-19 Doctor of Philosophy Doctorate Full Time Ms Sarah May Battersby
2023 Co-Supervisor Investigating the role of JAZF1 in the formation and function of human induced Regulatory T cells Doctor of Philosophy Doctorate Full Time Miss Hannah Rae Morgan
2022 Principal Supervisor Optimisation of Chimeric Antigen Receptor T Cells for Pan Solid Tumour Immunotherapy Doctor of Philosophy Doctorate Full Time Mr Jieren Zheng
2022 Principal Supervisor Optimisation of Chimeric Antigen Receptor T Cells for Pan Solid Tumour Immunotherapy Doctor of Philosophy Doctorate Full Time Mr Jieren Zheng

Date Role Research Topic Program Degree Type Student Load Student Name
2020 - 2024 Co-Supervisor Development of novel ovarian cancer treatment using CAR-T cells targeting LGR5 Doctor of Philosophy Doctorate Full Time Ms Wanqi Wang
2018 - 2020 Co-Supervisor Three-Dimensional Printing of Regulatory T-Cells: A Novel Immunotherapy to Prevent Transplantation Rejection Doctor of Philosophy Doctorate Full Time Mr Juewan Kim
2017 - 2021 Co-Supervisor Three-dimensional regulation: Establishing novel linkages between non-coding genetic variation and target genes Doctor of Philosophy Doctorate Full Time Mr Ning Liu
2017 - 2021 Principal Supervisor The Identification Of Genetic And Epigenetic Changes That Contribute To Type 1 Diabetes Doctor of Philosophy Doctorate Full Time Dr Ying Ying Wong
2016 - 2021 Principal Supervisor A NOVEL ROLE FOR ZEB2 AS A LINEAGE FIDELITY CHECKPOINT IN HUMAN CD4+ T CELLS Doctor of Philosophy Doctorate Full Time Mr Soon Wei Wong
2016 - 2023 Co-Supervisor Protein Kinase C zeta Regulates the Development of Cord Blood T Cells from the Immature Th2 to the Mature Th1 Cytokine Phenotype and its Implication in Development of Allergic Sensitization Doctor of Philosophy Doctorate Full Time Dr Khalida Perveen
2015 - 2018 Co-Supervisor Hormone and transcription factor regulation of cytokines in the mammary gland Doctor of Philosophy Doctorate Full Time Mr Vahid Atashgaran
2013 - 2021 Co-Supervisor DOES THE GUT MICROBIOME DRIVE THE DEVELOPMENT OF TYPE 1 DIABETES? Type 1 diabetes and the gut (TIGs) cohort Doctor of Philosophy Doctorate Part Time Dr Jessica Emily Harbison
2013 - 2018 Co-Supervisor T Regulatory Cells in Early Pregnancy in Mice Doctor of Philosophy Doctorate Full Time Miss Bihong Zhang
2011 - 2013 Co-Supervisor Longevity of Airway Gene Therapy for Cystic Fibrosis: Single and Repeat Lentiviral Dosing Doctor of Philosophy Doctorate Part Time Dr Patricia Lucia Cmielewski
2011 - 2015 Co-Supervisor Characterisation of PI16+ T helper cells Doctor of Philosophy Doctorate Full Time Mr Arunesh Pullaniparambil Mohandas
2011 - 2015 Co-Supervisor Cystic Fibrosis: The role of airway stem cells in sustained gene expression by lentiviral directed gene therapy Doctor of Philosophy Doctorate Full Time Dr Nigel Farrow
2009 - 2013 Principal Supervisor A Tumour Suppressor Role for FOXP3 and FOXP3-regulated MicroRNAs in Breast Cancer Cells Doctor of Philosophy Doctorate Full Time Miss Natasha McInnes
2008 - 2018 Principal Supervisor BMEA: Bayesian Modelling for Exon Array Data Doctor of Philosophy Doctorate Part Time Dr Stephen Martin Pederson
2006 - 2009 Co-Supervisor Regulatory T Cells, Th17 Effector Cells and Cytokine Microenvironment in Inflammatory Bowel Disease and Coeliac Disease Doctor of Philosophy Doctorate Part Time Dr Nicola Eastaff-Leung

Date Role Board name Institution name Country
2015 - ongoing Board Member Cell bank Australia children's medical research institute Australia

Date Role Committee Institution Country
2014 - ongoing Member RRI Executive Robinson Research Institute Australia
2009 - ongoing Vice-Chair WCHN IBC WCHN Australia

Date Role Membership Country
2014 - ongoing Member ISCT Australia
2004 - ongoing Member ASI Australia

Date Role Editorial Board Name Institution Country
2016 - ongoing Associate Editor Frontiers in Immunology Robinson Research Insitute Australia

Date Engagement Type Partner Name
2011 - ongoing Consultant BeckTon Dickenson

Connect With Me

External Profiles