Dr Ying Ying Wong
Grant-Funded Researcher (A)
School of Biomedicine
Faculty of Health and Medical Sciences
No information available as at 19/3/2018.
I am currently undertaking post-doctoral research that focuses on the identification of genetic and epigenetic changes that contribute to Type 1 Diabetes (T1D). T1D results from immune cell-mediated destruction of insulin-producing pancreatic beta cells. The reason a child develops T1D is poorly understood but appears to depend on a complex interaction of genetic predisposition and environmental factors, leading to a breakdown in tolerance normally maintained by Regulatory T (Treg) cells.
My research aims to identify alterations in chromatin accessibility and transcriptome in T cells from T1D patients. Incorporation of chromatin conformation capture contact maps allows us to connect dysregulated non-coding, regulatory enhancers to their long-range target genes. A key aspect of this research is the longitudinal nature of the sample collection so that genetic and epigenetic alterations causing immune dysregulation can be identified prior to the loss of pancreatic beta-cells for the development of interventions that prevent T1D occurrence.
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Appointments
Date Position Institution name 2022 - ongoing Grant-funded researcher University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2023 Award The Immunology of Diabetes Society (IDS) Travel award European Federation of Immunological Societies (EFIS) France - 2022 Award The Australasian Society for Immunology Bursary Australian and New Zealand Society for Immunology Australia - 2022 Award Best Post Doctorate Presentation Award Adelaide Immunology Retreat Australia - 2022 Award FHMS Research Travel Award University of Adelaide Australia - 2022 Award BioLegend Best Presentation Award | World immune regulation meeting Swiss Institute of Allergy and Asthma Research (SIAF) Switzerland - 2022 Award World Immune Regulation Meeting Travel Grant Swiss Institute of Allergy and Asthma Research (SIAF) Switzerland - 2022 Award Dean’s Commendation for Doctoral Thesis Excellence University of Adelaide Australia - 2022 Award JDRF Career Support and Travel Grant JDRF Australia Australia - 2021 Award The Australasian Society for Immunology Bursary Australian and New Zealand Society for Immunology Australia - 2019 Award Hans-Jürgen & Marianne Ohff Research Grant University of Adelaide Australia - 2019 Award Robinson Research Institute Travel Grant University of Adelaide Australia - 2018 Award Adelaide Medical School Research Travel Award University of Adelaide Australia - 2017 Scholarship ENDIA Study Supplementary Scholarship ENDIA/University of Adelaide Australia - 2017 Scholarship Adelaide Graduate Research Scholarships University of Adelaide Australia - 2014 Scholarship Adelaide International Undergraduate Scholarships University of Adelaide Australia - -
Education
Date Institution name Country Title 2017 - 2021 University of Adelaide Australia Doctor of Philosophy 2014 - 2016 University of Adelaide Australia Bachelor of Science (Honours) 2010 - 2013 Singapore Polytechnic Singapore Diploma in Biomedical Science (Medical Technology) -
Research Interests
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Journals
Year Citation 2023 Wong, Y. Y., Harbison, J. E., Hope, C. M., Gundsambuu, B., Brown, K. A., Wong, S. W., . . . Barry, S. C. (2023). Parallel recovery of chromatin accessibility and gene expression dynamics from frozen human regulatory T cells.. Scientific reports, 13(1), 15 pages.
2023 Dinh, D. T., Breen, J., Nicol, B., Foot, N. J., Bersten, D. C., Emery, A., . . . Russell, D. L. (2023). Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling. NUCLEIC ACIDS RESEARCH, 16 pages.
2022 Liu, N., Sadlon, T., Wong, Y. Y., Pederson, S., Breen, J., & Barry, S. C. (2022). 3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk. Epigenetics and Chromatin, 15(1), 24-1-24-21.
2021 Hope, C. M., Huynh, D., Wong, Y. Y., Oakey, H., Perkins, G. B., Nguyen, T., . . . Barry, S. C. (2021). Optimization of blood handling and peripheral blood mononuclear cell cryopreservation of low cell number samples. International Journal of Molecular Sciences, 22(17), 9129-1-9129-19.
Scopus3 WoS22020 Brown, C. Y., Sadlon, T., Hope, C. M., Wong, Y. Y., Wong, S., Liu, N., . . . Barry, S. C. (2020). Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease. Frontiers in Immunology, 11(September), 1-17.
Scopus9 WoS8 Europe PMC82020 Liu, N., Sadlon, T., Wong, Y. Y., Pederson, S., Breen, J., & Barry, S. C. (2020). 3DFAACTS-SNP: Using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of Type-1 Diabetes (T1D) risk. biorxiv.
- Zammit, N. W., Wong, Y. Y., Walters, S., Warren, J., Barry, S. C., & Grey, S. T. (n.d.). RelA Governs a Network of Islet-Specific Metabolic Genes Necessary for Beta-Cell Function. SSRN Electronic Journal.
2022-2023 Mapping the Immune defect in Type 1 Diabetes to the immune cells in cord blood, Inner Wheel Australia Foundation Trust. Grant Amount: $65,000. Role: PI.
2021-2023 Using 3D genomics to functionally connect genetic risk of Type 1 diabetes to the genes that drive loss of immune tolerance, Juvenile Diabetes Research Foundation Australia. Grant Amount: $505,000. Role: Co-I.
2021-2022 Connecting the genetic risk of T1D to the genes that are altered by it in immune cells, Diabetes Australia Research Trust. Grant Amount: $50,000. Role: Co-I.
2022-2023 Type 1 diabetes through the lens of single-cell transcriptomics: Turning targets into new therapies, Parse Biosciences Core Grant. Role: PI.
2022-2023 Using LentiMPRA a massive parallel reporter assay to link transcriptional control and genetic variation to disease and phenotypic traits, RRI Innovation Seed Funding Program. Grant Amount: $50,000. Co-I.
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