Professor Andrew Zannettino

Executive Dean

Health and Medical Sciences Faculty Office

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Andrew is the Executive Dean of the Faculty of Health and Medical Sciences at the University of Adelaide.

Prior to commencing as Executive Dean, Andrew held the positions of Pro Vice-Chancellor of Health Partnerships (University of Adelaide) and Executive Director of Research Strategy (Central Adelaide Local Health Network).

Andrew is a Professor of Experimental Haematology and co-directs the Myeloma Research Laboratory within the Precision Cancer Medicine Theme at the South Australian Health and Medical Research Institute (SAHMRI). He is a recognised leader in the field of mesenchymal stem cell biology and holds numerous patents covering the composition and regenerative properties of Mesenchymal Precursor Cells (MPCs), a rare cell population present in many postnatal tissues. The family of patents underpin the cell therapy company, Mesoblast Ltd.

Andrew is a founding member of the Medical and Scientific Advisory Group (MSAG) of Myeloma Australia, the peak body in Australian focused on PBAC submissions, guidance documents and advocacy for myeloma. He, additionally, serves as non-executive director of AusHealth Pty Ltd and a member of a number of intramural and extramural boards.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

Research Interests

Myeloma and Bone Cancer Research

Multiple myeloma is haematological malignancy characterised by the clonal proliferation of plasma cells, an immune cell type that normally protects us against infection. Myeloma is the second most common blood cancer and more than 140,000 people are diagnosed each year worldwide. Despite recent advances in treatment, myeloma remains universally fatal and has a 10-year survival rate of approximately 28%. The main clinical manifestations of myeloma are the development of osteolytic bone lesions, bone pain, hypercalcaemia, renal insufficiency, suppressed immunoglobulin production and increased bone marrow angiogenesis (blood vessel formation). Myeloma is preceded by a premalignant (asymptomatic) monoclonal gammopathy of uncertain significance (MGUS) stage. The factors that trigger the progression from MGUS to myeloma remain to be determined; however, our studies show that both intrinsic genetic changes and extrinsic factors play a role in disease progression. The Myeloma Research Laboratory’s research is focussed on detecting the key signalling pathways that are deregulated during disease development and determining what microenvironmental changes occur during disease pathogenesis. We believe that these approaches will enable us to identify new molecular markers of disease risk and to design drugs against novel therapeutic targets.

The MRL has made, and continues to make significant contributions to the field through ongoing projects in:

Identifying the mechanisms of myeloma associated bone loss
Identifying the genetic, transcriptional and epigenetic changes that trigger the progression from asymptomatic MGUS to myeloma
Determining why the bone marrow is a “hot-spot” for myeloma plasma cell metastasis
Identifying the mechanisms governing dissemination and relapse in multiple myeloma
Identifying how myeloma plasma cells affect mesenchymal stem cell differentiation.
The use of single cell sequencing to discover tumour-associated changes in the bone microenvironment of myeloma patients: identification of prognostic markers and novel therapeutic targets
The use of high-precision proteomics to identify novel serum biomarkers to identify high-risk smouldering myeloma patients prior to progression to active multiple myeloma
Identifying a role for the mTOR pathway in mesenchymal stem cell biology and bone formation.
Assessing the effectiveness of targeting skeletal mTORC1 as a novel approach to treat diet-induced insulin resistance

Therapeutic Use of Mesenchymal Progenitor Cells

Mesenchymal Progenitor Cells (MPC) are rare stem cells present within post-natal tissues which possess promising therapeutic properties. In the late 90’s, collaborative studies in association with Professor Stan Gronthos (Mesenchymal Stem Cell Laboratory, UA/SAHMRI) and Professor Paul Simmons (Mesoblast Ltd.) led to the patenting of technologies covering the identification and isolation of these rare cells from bone marrow. The family of patents surrounding this technology were assigned to Angioblast Systems Inc., New York, USA in November 2004 facilitating the formation of Mesoblast Ltd, an Australian Stock Exchange listed company (http://www.mesoblast.com). In return for the assignment of these patents, the IMVS/Medvet/SA Pathology (my substantive employer at that time) received a significant parcel of shares in this company. From January 2005 until December 2016, I have served as a consultant to both Angioblast Systems Inc. and Mesoblast Ltd. and continued to receive funding to support the improvement/development of existing/new intellectual property and to fund large pre-clinical animal models of disease.

Research Collaborations

My expertise in the fields described above has led to active collaborations with scientists/clinicians throughout the world as detailed below.

In 1994-1995, I developed a powerful retroviral-based expression cloning strategy to enable isolation of genes encoding cell surface molecules that participate in intercellular interactions. This methodology has led to numerous collaborations and ongoing consultation work with scientists including:

Dr H-J. Buhring, University of Tubingen, Germany. Retroviral Expression cloning of cell surface antigens expressed by normal and leukaemic haemopoietic stem cells;
Prof. Leonie K. Ashman, University of Newcastle. Retroviral Expression cloning of drug resistance genes;
Prof. James T. Triffit, Botnar Research Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK. Retroviral Expression cloning of osteoblast-related cell surface antigens;
Dr S. Watt, MRC Molecular Haematology Unit, The Institute of Molecular Medicine, University of Oxford, UK. Retroviral Expression cloning of novel cell surface molecules.

My research into myeloma-associated bone loss and molecular mechanisms of myeloma disease pathogenesis has led to further collaborations with a number of academic and industry-based scientists including:

Prof. John Shaughnessy, Formerly of University of Arkansas, Little Rock, Arkansas, USA and founder of SignalGenetics^TM, Carlsbad, CA. The role of DKK-1 in myeloma-associated bone loss;
Dr Daniel Peet, Department of Bichemistry, Molecular Life Sciences, University of Adelaide: Role of CXCL12 (SDF-1)/CXCR4 in Pathological Angiogenesis and Osteolytic Bone Disease in Multiple Myeloma;
Dr Phil Kearney, Santaris Pharma, Copenhagen, Denmark: Role of CXCL12 (SDF-1)/CXCR4 in Pathological Angiogenesis and Osteolytic Bone Disease in Multiple Myeloma;
Prof. Nobutaka Fujii and Prof. Hirokazu Tamamura, Graduate School of Pharmaceutical Sciences Kyoto University Department of Bioorganic Medicinal Chemistry, JAPAN, Role of SDF-1 in myeloma;
A/Prof. Kevin Lynch, Novartis, Sydney, Australia, Tyrosine Kinase Inhibition as a Potential Modality to Control Osteolytic Bone Disease: A New Role for Imatinib Mesylate and Second Generation Bcr-Abl Inhibitors;
Dr Elisabeth Buchdunger and Dr Paul Manley, Novartis Pharma, Skeletal Effects of the Abl Kinase Inhibitors, Nilotinib and Imatinib;
Dr Francis Lee and Dr Richard Smykla, Bristol-Myers Squibb, Skeletal Effects of the Abl Kinase Inhibitors, Dasatinib;
Prof. Vijay Modur, Novartis Pharmaceuticals Corporation, Cambridge, MA, USA. Novel mediators of multiple myeloma metastases to the bone;
Prof. William Dougall, Amgen, Seattle, Washington, USA, The role of RANKL in myeloma-associated bone loss;
Dr Daniela Niepel, Global Medical Executive Director, Amgen GmbH, Rotkreuz, Switzerland. The application of bone targeting agents (BTA) in oncology.
Prof. Peter Croucher, Bone Biology Laboratory, Bone Biology Division, Garvan Institute of Medical Research, NSW, AUS. The role of the bone marrow microenvironment in the pathogenesis of myeloma;
Dr Daniel Worthley, University of Adelaide, Adelaide, Australia, The role of the bone marrow microenvironment in the pathogenesis of myeloma;
Prof. Siddhartha Mukherjee, Columbia University, NY, USA. The role of the bone marrow microenvironment in the pathogenesis of myeloma;
Prof. Orest Blaschuk, Urology Research Laboratories, Division of Urology, McGill University Health Centre, Canada and Zonula Inc. The use of Cadherin antagonists to treat multiple myeloma;
Prof. Jonathan Licht, University of Florida Cancer Centre. The role of EMT in myeloma disease dissemination and disease progression;
Prof. Ricky Johnstone, Gene Regulation Laboratory, Peter MacCallum Cancer Centre, The role of the bone marrow microenvironment in the pathogenesis of myeloma;
Associate Professor Simon Leedham, Wellcome Trust Centre for Human Genetics, Oxford, The role of the bone marrow microenvironment in the pathogenesis of myeloma;
Prof. Charles Mullighan, Hematological Malignancies Program, St. Jude Children’s Research Hospital, Understanding clonal evolution in multiple myeloma;
Dr Gareth Davies, Senior Research Scientist / Project Leader, UCB Celltech – New Medicines, Slough, UK. Targeting stromal derived Gremlin 1 as a novel therapeutic modality to treat multiple myeloma
Prof. Gareth Morgan, University of Arkansas, Myeloma Institute for Research and Therapy (UAMS), Understanding clonal evolution in multiple myeloma.
Prof. Tilman Brummer, Institute of Molecular Medicine and Cell Research Albert-Ludwigs University of Freiburg, Germany. The role of the novel tumour suppressor gene, SAMSN1, in the pathogenesis and metastasis of multiple myeloma.

My research into physiological and aberrant bone remodelling and novel skeletally-derived factors that regulate glucose metabolism has led to collaborations with a number of academic and industry-based scientists including:

Prof. D.M. Findlay, Dr Gerald J. Atkins and Dr. Andreas Evdokiou, Discipline of Orthopaedics and Trauma, Royal Adelaide Hospital and the University of Adelaide. Normal and pathological bone remodelling;
Dr Colin Dunstan, University of Sydney and formerly of Amgen Inc, CA, USA; The Role of OPG in bone metabolism;
A/Prof Barry C Powell, Dr Peter J Anderson and Prof David David, Child Health Research Institute and The Women’s and Childrens Hospital, Adelaide, South Australia: Mechanisms of premature cranial fusion and development of novel adjunct approaches to treatment;
Prof H. Zreiqat, School of Pathology, University of New South Wales, Sydney, Australia. Behaviour of osteoclasts and bone cells on bio-material surfaces;
Prof D. R. Haynes, Department of Pathology, University of Adelaide, Adelaide, South Australia. The role of TNF family members TWEAK and TNF-alpha in bone remodelling;
A/Prof Sofianos Andrikopoulos, The University of Melbourne, The University of Melbourne. Skeletal endocrine signalling in the regulation of glucose metabolism;
Dr Paul Baldock, Garvan Institute of Medical Research, Garvan Institute of Medical Research. The University of New South Wales, Skeletal endocrine signalling in the regulation of glucose metabolism;
Christopher Proud, South Australian Health and Medical Research Institute, SA, AUS. Targeting skeletal mTORC1 as a novel approach for the treatment of diet-induced insulin resistance.
William Cawthorn, University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, Edinburgh, Scotland. The role of raptor/mTORC1 and bone marrow adipose tissue (BMAT) in the control of whole-body glucose metabolism

My research into mesenchymal precursor cell biology and application has led to collaborations with a number of biotechnology companies, including Angioblast Systems Inc., Mesoblast Ltd. and Genzyme International. In addition, I also collaborate and consult for a number of academic scientists including:

Prof. Silviu Itescu, Mesoblast Ltd.: Clinical Application of Mesenchymal Precursor Cells for bone repair, articular cartilage regeneration, disc cartilage regeneration, cellular therapy of heart attack/heart failure, peripheral arterial disease and wound ulcers;
A/Prof. Robert Moore, formerly head of the Adelaide Centre for Spinal Research, Institute of Medical and Veterinary Science, Adelaide, South AUSTRALIA: A Preclinical trial of the potential for cultured mesenchymal precursor cells to restore extracellular matrix and normal mechanical function to degenerate intervertebral discs;
Prof. Peter Ghosh, Institute of Nutraceutical Research, Brookevale, NSW, Australia: Cartilage Regenerative Potential of Ovine Mesenchymal Precursor Cells (MPC);
A/Prof John Field, Flinders University of South Australia, School of Medicine, Bedford Park, South Australia: Evaluation of the safety and efficacy of Allogeneic Mesenchymal Progenitor Cells (MPC) for the repair of critical size defects in an ovine tibial model;
Prof. Stephen Worthley, formerly Cardiovascular Investigation Unit, Royal Adelaide Hospital, Adelaide, South Australia: A study of the cardiac regenerative potential of immunoselected ovine bone marrow mesenchymal stem cells;
Dr Cory Xian and Prof. Bruce Foster, Bone Growth Foundation, University of South Australia and Department of Orthopaedic Surgery, Women's and Children's Hospital. Molecular pathways for the bony repair of injured growth plate cartilage;
Prof. Richard Harvey and Professor Robert Graham, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. Identification of endogenous cardiomyogenic stem cells.

From 2005 to 2016, I served as a scientific consultant for Mesoblast Ltd. where I helped to consolidate and expand our stem cell-based technology patent family and successfully completed key milestones such as the development of GMP-grade MPC isolation and culture expansion standard operational protocols. This resulted in an increase in capital investment to support the commencement of several phase II/III cardiac and orthopaedic clinical studies. Funds from Mesoblast Ltd were used to continue basic R&D in our laboratory and for initiating new pre-clinical animal studies within the IMVS/ Hanson Institute/ RAH/ University of Adelaide campuses. Collectively, these studies formed the foundation of new IND (investigative new drug) applications submissions to the USA FDA for future phase I/II/III human clinical trials involving different health centres and laboratories in Adelaide, Australia and the USA.

Research Output

I have co-authored more than 300 refereed publications, book chapters and review articles (not including published abstracts). Many of these articles are published in premier Haematology and Orthopaedic journals (BLOOD, Leukemia, BJH, JBMR, Bone), Cancer journals (Cancer Research, Clinical Cancer Research) and Stem Cell journals (Cell Stem Cell, Stem Cells). My publications have received in excess of 17,000 citations and my H Factor = 73. Refer to Publications section for full details.

Presentations

I have been invited to present my laboratory’s findings at more than 45 national and international forums since 2010. In addition, I have co-authored more than 100 abstracts with more than 60 of these being published as Meeting Proceedings.

Conference Presentations
Year	National/ International	Event Title	Role
2018	International	The Myeloma 2018 Workshop, San Diego, CA, USA	Invited Speaker
2017	National	Monash Haematology Seminar Series, Victoria, Australia	Invited Speaker
2016	National	Translating Research for Impact: Strategies for Success, Adelaide, Australia	Invited Speaker
2016	National	Inaugural National Myeloma Workshop, Yarra Valley, Victoria, Australia	Invited Speaker
2016	National	New Directions in Leukaemia Research meeting March 16-19, 2016, Noosa, QLD, AUS	Invited Speaker
2015	International	"PACIFICHEM 2015 Conference December 15-20, 2015 in Honolulu, HI."	Invited Speaker
2014	International	American Society of Haematology	Invited Speaker
2014	National	Sydney Cancer and Bone Meeting	Invited Speaker
2013	International	Australian and New Zealand Bone and Mineral Society	Invited Speaker
2013	National	Frontiers in Skeletal Biology	Invited Speaker
2012	National	Combio 2012	Invited Speaker
2012	National	SA Multiple Myeloma Interest Group	Invited Speaker
2012	National	SVRI-Seminar Series	Invited Speaker
2012	National	The Australian Health and Medical Research Congress	Invited Speaker
2011	International	Austalian and New Zealand Bone and Mineral Research	Plenary Speaker
2010	National	Adelaide Bone Group Meeting	Invited Speaker
2010	International	American Society of Haematology	Session Chair
2010	National	Annual HSANZ - SA “Blood Club Meeting”,	Invited Speaker
2010	National	Leukaemia Foundation of Australia – Myeloma Awareness Day	Invited Speaker
2009	International	Asia Pacific Haematology Summit	Keynote Speaker
2009	International	HAA 2009; 2009 Annual Scientific Meeting of HSANZ, ANZSBT, ASTH	Keynote Speaker
2009	National	Health Development Adelaide Symposium	Presenter
2009	International	Janssen Cilag, Multiple Myeloma 3 (MM3) meeting	Presenter
2009	International	Novartis APECHO-APTM Workshop	Keynote Speaker
2008	International	American Society of Haematology	Poster Presenter
2008	National	Bio Innovation SA Networking Forum – Bio Innovation Osteo Networking Evening	Keynote Speaker
2008	International	Fifth Clare Valley Bone Meeting	Keynote Speaker
2008	National	NCRIS 5.5 CGMP - SEMINAR/WORKSHOP - “NANO-ENGINEERING FOR CELLS”	Presenter
2008	National	Royal Adelaide Hospital Medical Grand Round	Presenter
2007	National	Barbara Ell Seminar Series, Victor Chang Cardiac Research Institute	Presenter
2007	International	Novartis Oncology Research and Development Symposium	Presenter
2007	National	2007 Mater Medical Research Institute Symposium	Presenter
2006	International	American Society of Haematology	Session Chair
2006	National	Department of Orthopaedics and Trauma, Royal Melbourne Hospital	Presenter
2006	National	Inaugural Tissue Engineering Symposium (SuTEN), Biomedical Engineering at Sydney University School of Aerospace, Mechanical and Mechatronic Engineering and The Bosch Institute	Presenter
2006	International	Novartis Oncology Australia, Research and Development Symposium, The Intercontinental Hotel	Keynote Speaker
2005	National	ANZ Matrix Biology Society Conference, Whalers Inn, Victor Harbour, SA	Keynote Speaker
2005	National	Department of Genetic Medicine, Womens and Children’s Hospital	Presenter
2005	National	Division of Molecular Pathology, IMVS	Presenter
2005	National	The Basil Hetzel Institute, The Queen Elizabeth Hospital	Presenter
2004	International	Haematology Society of Australia and New Zealand, Exhibition and Convention Centre	Presenter
2003	National	Adelaide Blood Club	Invited Speaker
2003	National	Division of Clinical Biochemistry, IMVS	Invited Speaker
2003	National	Division of Molecular Pathology, IMVS	Invited Speaker
2003	National	Division of Pathology, IMVS	Invited Speaker
2003	National	The Alfred Hospital	Invited Speaker
2002	International	Australian and New Zealand Orthopaedic Research Society	Invited Speaker
2002	National	Child Health Research Institute	Invited Speaker
2002	National	Department of Medicine, University of Adelaide	Invited Speaker
2002	National	Molecular Biology of Skeleton	Invited Speaker
2001	National	Adelaide Blood Club	Invited Speaker
2001	International	Molecular Mechanisms of Skeletal Disease mediated by Myeloma, NIH	Invited Speaker
2001	International	Zymogenetics	Invited Speaker
1998	International	Australian and New Zealand Orthopaedic Research Society	Invited Speaker
1998	International	Haematology Society of Australia and New Zealand	Invited Speaker
1998	National	Hanson Symposium	Invited Speaker

Additional Evidence of Research Leadership

When I joined the UA School of Medical Sciences (SoMS), I served as a member of the Research Committee. In January 2014, I was appointed as Chair of this committee, and immediately instituted 4 new funding programs designed to drive research activity, including an ECR “kick start” award, a strategic equipment fund, an ECR/MCR travel award and a publication award program.

I was also appointed to the SoMS board, the FHMS Research Committee and was the Deputy Chair of the Adelaide Medical and Nursing School (AMNS) Project Committee overseeing the construction of a new $246 million Medical/Nursing/Research facility in the new West End Biomedical Research Precinct which will house approximately 650 Researchers. In January 2015, I was appointed to Deputy Head od School, SoMS. In March 2015, the Executive Dean, Professor Alastair Burt appointed me to establish and chair the Research Strategy Taskforce (RSTF). The RSTF was charged with the responsibility of devising a new research strategy to promote research excellence within the FHMS. This work led to the development of an adaptable strategic framework to enhance research education (HDR/honours), develop research strengths, build enabling technologies/research infrastructure and develop pathways to improved health care and the generation of valuable intellectual property.

My national standing in the fields of cell and cancer biology has been recognised by my appointment to the NHMRC Grant Review Panel (GRP) for Cell biology (2005, 2006) and Oncology (2010) and Assigners Academy (2014-2018). In recognition of my international standing in the field of myeloma-associated bone loss, I was invited by the Leukaemia Research Fund (LRF) of UK, to participate in a “site visit” of Myeloma Program of Prof. Peter Croucher, University of Sheffield, UK, to assess his application for program funding through the LRF in both 2006 and 2009. In addition, I was invited to participate as a moderator for the 2006 American Society of Haematology (ASH) Annual Meeting, for the session titled “Multiple Myeloma: Microenvironment”. I was invited to be an Abstract Reviewer of the “Myeloma-Pathophysiology and Preclinical studies excluding Therapy” Category for the 52^nd Annual Meeting of the ASH, a prestigious appointment bestowed upon recognized experts in the field.

As a testament to my expertise in my chosen fields, I have been asked to present my laboratory's findings at numerous scientific meetings and institutions (see “Conference Presentations”) and I have been asked to contribute to numerous review articles and book chapters (see “Publications”). As a recognised expert in the areas of skeletal, stem and cancer biology, I am asked to review >3 manuscripts per month for more than 20 journals including BLOOD, Leukemia, Leukemia and Lymphoma, Experimental Hematology, Haematologica, Journal of Bone and Mineral Research, Leukemia, Cell Stem Cell, Clinical Cancer Research, Cancer Research, International Journal of Cancer, Bone, FASEB Journal. I am also regularly asked to review applications for a number of funding bodies including the NHMRC, Cancer Council of South Australia, Cure Cancer Australia, Leukaemia Research Fund (UK), The Health Research Board (HRB) of Ireland, Singapore Ministry of Education and the Research Grants Council (RGC) of Hong Kong. I was approached by the Wiley-Blackwell publishing house to assess the merits of publication of a book entitled: “Stem Cells: Science and Business Strategies” by A. Vertes et al.

As further evidence of my scientific standing, I have served on organising committees involved in staging both national and international scientific meetings including; the 2004 Hanson Symposium Stem Cell Meeting (Adelaide, SA, 2004); the 10th International Myeloma Congress (Sydney, NSW, 2005); the Clare Bone Meeting (Clare Valley, SA, 2006) and the Australian Myeloma Workshop (2016). I was a member of a committee comprised of stakeholders for the Commonwealth's $35 million Super Science Initiative (SSI) - Translating Health Discovery (THD) and represent the Centre for Cancer Biology (CCB) as a Subject Matter Expert (SME) charged with the role of identifying the facilities requirements for the South Australian Health and Medical Research Institute (SAHMRI). Finally, I have served on the Fellowships and Scholarships Committee for the Leukaemia Foundation of Australia.

Clinical Outcomes of Research

As a member of MSAG, I have provided guidance on both myeloma and supportive treatment strategies and have co-authored guidelines for the safe use of bisphosphonates and Clinical Practice Guidelines. Furthermore, my work has raised the awareness amongst clinicians of the importance of routine examination of CTX levels in patients. CTX (the C-telopeptide of the α1 chain of collagen type 1), a reliable marker of bone turnover, is now being used locally as a routine test for all myeloma patients at diagnosis and restaging. CTX, when used in conjunction with paraprotein levels and bone marrow assessment can detect early progression of myeloma. This is a palpable achievement and one that has led to better outcomes for patients.

As a co-inventor of the Mesenchymal Progenitor Cell (MPC) cellular therapy, I have been instrumental in developing a therapy that is likely to have a significant impact in the areas of spinal fusion, osteoarthritis, congestive heart failure, heart attacks, eye diseases, diabetes, and bone marrow repair.

Patents

I am a co-inventor of patents that describe the isolation and composition of matter of mesenchymal precursor cells (MPC), a unique population of adult stem cells with tissue reparative properties. This family of patents were assigned to Angioblast Systems Inc., New York, USA in November 2004 facilitating the formation of Mesoblast Ltd, an Australian Stock Exchange listed company. In 2010, Mesoblast acquired Angioblast Systems Inc forming the Mesoblast Group.

Initial Patents Assigned to Angioblast Systems Inc. Leading to formation of Mesoblast Ltd.

Patent: WO 01/04268 A1: AUSTRALIA, 1999

Status: Granted

Inventors: Paul Simmons, Andrew Zannettino, Stan Gronthos, Description of patent: Mesenchymal Precursor Cells. Founding patent for the formation of Mesoblast Ltd.

Applicability/Impact: Novel discovery of multi potential stem cells from connective tissue for tissue regeneration. Patent granted in AU, US, CA, ES, EP.

Patent: WO 2004/084921 A1: AUSTRALIA, 2003

Status: Granted

Inventors: Stan Gronthos and Andrew Zannettino.

Description of patent: Perivascular Mesenchymal Precursor Cell Induced Blood Vessel Formation. Founding patent for the formation of Mesoblast.

Applicability/Impact: The use of stem cells to regenerate blood vessels during tissue regeneration. Patent granted in US, AU, EP, CA, CN, ES.

Patent: WO 2004/085630 A1: AUSTRALIA, 2003

Status: Granted

Registered in names of (Inventors): Stan Gronthos, Andrew Zannettino and Songtao Shi.

Description of patent: Perivascular Mesenchymal Precursor Cells. Founding patent for the formation of Mesoblast Ltd.

Applicability/Impact: Discovery of unique perivascular multi potential stem cell for regeneration of tissue. Patent granted in US, AU, CA, CN.

Patent: WO 2006/032092 A1: UNITED STATES OF AMERICA, 2004

Status: Granted

Inventors: Andrew Zannettino and Stan Gronthos.

Description of patent: Multipotential expanded Mesenchymal Precursor Cell progeny and uses there off. Founding patent for the formation of Mesoblast Ltd.

Applicability/Impact: Discovery of unique multi-potential adult stem cell for tissue regeneration. Patent granted in US, AU, EP, CN.

Patent: WO 2006/032075 A1: AUSTRALIA, 2004

Status: Granted

Inventors: Stan Gronthos and Andrew Zannettino.

Description of patent: Method of enhancing proliferation and/or survival of mesenchymal precursor cells. Founding patent for formation of Mesoblast Ltd.

Applicability/Impact: Novel protocols for developing GMP ex vivo expansion protocols for the manufacture of MPC for clinical use. Patent granted in US, AU, CN.

Supportive Patents Assigned to Mesoblast Ltd.

Patent: PCT/AU2016/050438: AUSTRALIA, 2015

Status: Awarded (PCT)

Inventors: Stan Gronthos, Andrew CW Zannettino, Stephen Fitter.

Description of patent: Methods and Products for Enriching and Isolating Stem Cells. Patent assigned to Mesoblast Ltd.

Applicability/Impact: Identification and characterisation of the STRO-1 antigen a marker of mesenchymal precursor cells. Purification of MPC for clinical applications.

Patent: WO 2010/019997 A1: UNITED STATES OF AMERICA, 2008

Status: Granted

Inventors: Andrew Zannettino and Stan Gronthos

Description of patent: Monoclonal antibody STRO-4 selection of mesenchymal precursor cells. Patent assigned to Mesoblast Ltd.

Applicability/Impact: First reagent for isolation of MPC for pre-clinical ovine and human clinical studies. Patent granted in USA and AU.

Patent: W02006/108229 A1: UNITED STATES OF AMERICA, 2006

Status: Granted

Registered in names of Inventors: Andrew Zannettino, Stan Gronthos and Paul Simmons.

Description of patent: Isolation of adult multipotential Cells by tissue non-specific alkaline phosphatase. Patent assigned to Mesoblast Ltd.

Applicability/Impact: Novel stem cell marker developed into a GMP reagent for clinical human trials. Patent granted in USA, AU, EP, CA, HK.

In addition to the Mesoblast Ltd-related patents, I am also a substantive inventor of the following patents:

Patent: PCT 1809946.5

Status: PCT filed June 2018, UK IPO

Registered in names of Inventors: Gareth Davies (UCB Biopharma SPRL), Andrew Zannettino, Duncan Hewett, Kimberley Clark, Kate Vandyke and Bill Panagopoulos (The University of Adelaide), (Simon Leedham) Oxford University Innovation Limited.

Description of Patent: Prevention and treatment of cancer

Applicability/Impact: Use of Gremlin 1 antagonists to prevent and treat cancer

Patent: PCT/AU2016/050438

Status: Granted

Registered in names of Inventors: Andrew Zannettino, Stephen Fitter, Stan Gronthos

Description of patent: Methods and products for enriching and isolating stem cells. Patent owned by the University of Adelaide.

Applicability/Impact: Describes HSC70 as a stem cell antigen and the use of anti-HSC7 reagents to isolate and enrich for stem cells

Patent granted in USA, AU, EP, CA, HK.

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
1999	Award	Young Investigator Award	Hanson Centre for Cancer Research	Australia	-
1998	Award	Johnson and Johnson Young Investigator award	Australian and New Zealand Orthopaedics Research Society	Australia	-
1992	Award	Postgraduate Scholarship Award	University of Adelaide	Australia	-

Research Interests

Cancer Biology and Clinical Oncology Translational Health Outcomes Innovative Therapeutics

Journals

Year	Citation
2015	Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2015). Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Letters, 357(1), 160-169. DOI Scopus41 WoS36 Europe PMC34
2015	Martin, S., Fitter, S., Dutta, A., Matthews, M., Walkley, C., Hall, M., . . . Zannettino, A. (2015). Brief report: The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation. Stem Cells, 33(4), 1359-1365. DOI Scopus80 WoS70 Europe PMC69
2015	Cakouros, D., Isenmann, S., Hemming, S., Menicanin, D., Camp, E., Zannetinno, A., & Gronthos, S. (2015). Novel basic helix-loop-helix transcription factor hes4 antagonizes the function of twist-1 to regulate lineage commitment of bone marrow stromal/stem cells. Stem Cells and Development, 24(11), 1297-1308. DOI Scopus27 WoS24 Europe PMC26
2015	Martin, S., Gan, Z., Fitter, S., To, L., & Zannettino, A. (2015). The effect of the PI3K inhibitor BKM120 on tumour growth and osteolytic bone disease in multiple myeloma. Leukemia Research, 39(3), 380-387. DOI Scopus20 WoS18 Europe PMC15
2015	Cheong, C., Chow, A., Fitter, S., Hewett, D., Martin, S., Williams, S., . . . Vandyke, K. (2015). Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo. Experimental Cell Research, 332(1), 24-38. DOI Scopus32 WoS26 Europe PMC28
2015	Gan, Z., Fitter, S., Vandyke, K., To, L., Zannettino, A., & Martin, S. (2015). The effect of the dual PI3K and mTOR inhibitor BEZ235 on tumour growth and osteolytic bone disease in multiple myeloma. European Journal of Haematology, 94(4), 343-354. DOI Scopus32 WoS28 Europe PMC23
2015	Gupte, A., Baker, E., Wan, S., Stewart, E., Loh, A., Shelat, A., . . . Walkley, C. (2015). Systematic screening identifies dual PI3K and mTOR Inhibition as a conserved therapeutic vulnerability in osteosarcoma. Clinical Cancer Research, 21(14), 3216-3229. DOI Scopus59 WoS47 Europe PMC46
2015	Baker, E., Taylor, S., Gupte, A., Sharp, P., Walia, M., Walsh, N., . . . Walkley, C. (2015). BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Scientific reports, 5(1), 10120-1-10120-14. DOI Scopus106 WoS91 Europe PMC92
2015	Forristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., . . . Levesque, J. P. (2015). Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia, 29(10), 2075-2085. DOI Scopus33 WoS27 Europe PMC33
2014	Ahmed, F., Roy Choudhury, N., Dutta, N., Zou, L., & Zannettino, A. (2014). Fabrication and characterisation of an electrospun tubular 3D scaffold platform of poly(vinylidene fluoride-co-hexafluoropropylene) for small-diameter blood vessel application. Journal of Biomaterials Science, Polymer Edition, 25(18), 2023-2041. DOI Scopus10 WoS8 Europe PMC4
2014	Noll, J., Hewett, D., Williams, S., Vandyke, K., Kok, C., To, L., & Zannettino, A. (2014). SAMSN1 is a tumor suppressor gene in multiple myeloma. Neoplasia, 16(7), 572-585. DOI Scopus39 WoS31 Europe PMC38
2014	Noll, J., Williams, S., Tong, C., Wang, H., Quach, J., Purton, L., . . . Zannettino, A. (2014). Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells. Haematologica, 99(1), 163-171. DOI Scopus99 WoS78 Europe PMC74
2014	Richardson, J., Psaltis, P., Frost, L., Paton, S., Carbone, A., Bertaso, A., . . . Worthley, S. (2014). Incremental benefits of repeated mesenchymal stromal cell administration compared with solitary intervention after myocardial infarction. Cytotherapy, 16(4), 460-470. DOI Scopus22 WoS21 Europe PMC17
2014	Zinonos, I., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., Denichilo, M., . . . Evdokiou, A. (2014). Doxorubicin overcomes resistance to drozitumab by antagonizing inhibitor of apoptosis proteins (IAPS). Anticancer Research, 34(12), 7007-7020. Scopus9 WoS4 Europe PMC7
2014	Zinonos, I., Luo, K., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., . . . Evdokiou, A. (2014). Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer. International Journal of Oncology, 45(2), 532-540. DOI Scopus20 WoS20 Europe PMC16
2014	Ahmed, F., Dutta, N., Zannettino, A., Vandyke, K., & Choudhury, N. (2014). Engineering interaction between bone marrow derived endothelial cells and electrospun surfaces for artificial vascular graft applications. Biomacromolecules, 15(4), 1276-1287. DOI Scopus22 WoS15 Europe PMC8
2014	Ahmed, F., Choudhury, N., Dutta, N., Brito E Abreu, S., Zannettino, A., & Duncan, E. (2014). Interaction of platelets with poly(vinylidene fluoride-co- hexafluoropropylene) electrospun surfaces. Biomacromolecules, 15(3), 744-755. DOI Scopus16 WoS16 Europe PMC8
2014	Hemming, S., Cakouros, D., Isenmann, S., Cooper, L., Menicanin, D., Zannettino, A., & Gronthos, S. (2014). EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification. Stem cells, 32(3), 802-815. DOI Scopus224 WoS189 Europe PMC176
2014	Frith, J., Menzies, D., Cameron, A., Ghosh, P., Whitehead, D., Gronthos, S., . . . Cooper-White, J. (2014). Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration. Biomaterials, 35(4), 1150-1162. DOI Scopus61 WoS50 Europe PMC40
2013	Ahmed, F., Choudhury, N., Dutta, N., Zannettino, A., & Knott, R. (2013). Near superhydrophobic fibrous scaffold for endothelialization: Fabrication, characterization and cellular activities. Biomacromolecules, 14(11), 3850-3860. DOI Scopus21 WoS21 Europe PMC11
2013	Richardson, J., Bertaso, A., Frost, L., Psaltis, P., Carbone, A., Koschade, B., . . . Worthley, S. (2013). Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of invivo assessment of ventricular function in rats. Laboratory Animals, 47(4), 291-300. DOI Scopus7 WoS6 Europe PMC5
2013	Frith, J., Cameron, A., Menzies, D., Ghosh, P., Whitehead, D., Gronthos, S., . . . Cooper-White, J. (2013). An injectable hydrogel incorporating mesenchymal precursor cells and pentosan polysulphate for intervertebral disc regeneration. Biomaterials, 34(37), 9430-9440. DOI Scopus140 WoS106 Europe PMC84
2013	Goldschlager, T., Oehme, D., Ghosh, P., Zannettino, A., Rosenfeld, J., & Jenkin, G. (2013). Current and future applications for stem cell therapies in spine surgery. Current Stem Cell Research & Therapy, 8(5), 381-393. DOI Scopus18 WoS10 Europe PMC8
2013	Richardson, J., Bertaso, A., Psaltis, P., Frost, L., Carbone, A., Paton, S., . . . Worthley, S. (2013). Impact of timing and dose of mesenchymal stromal cell therapy in a preclinical model of acute myocardial infarction. Journal of Cardiac Failure, 19(5), 342-353. DOI Scopus45 WoS41 Europe PMC32
2013	Richardson, J., Nelson, A., Zannettino, A., Gronthos, S., Worthley, S., & Psaltis, P. (2013). Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells-taking the next step. Stem Cell Reviews, 9(3), 281-302. DOI Scopus23 WoS22 Europe PMC21
2013	Vandyke, K., Chow, A., Williams, S., To, L., & Zannettino, A. (2013). Circulating N-cadherin levels are a negative prognostic indicator in patients with multiple myeloma. British Journal of Haematology, 161(4), 499-507. DOI Scopus16 WoS18 Europe PMC16
2013	Thomas, D., Powell, J., Green, B., Barry, E., Ma, Y., Woodcock, J., . . . Guthridge, M. (2013). Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology, 11(3), 1-14. DOI Scopus20 WoS16 Europe PMC19
2013	Arthur, A., Panagopoulos, R., Cooper, L., Menicanin, D., Parkinson, I., Codrington, J., . . . Gronthos, S. (2013). EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair. Journal of Bone and Mineral Research, 28(4), 926-935. DOI Scopus41 WoS35 Europe PMC32
2013	Vandyke, K., Fitter, S., Drew, J., Fukumoto, S., Schultz, C., Sims, N., . . . Zannettino, A. (2013). Prospective histomorphometric and DXA evaluation of bone remodeling in imatinib-treated CML patients: Evidence for site-specific skeletal effects. Journal of Clinical Endocrinology and Metabolism, 98(1), 67-76. DOI Scopus25 WoS22 Europe PMC22
2012	Castrechini, N., Murthi, P., Qin, S., Kusuma, G., Wilton, L., Abumaree, M., . . . Kalionis, B. (2012). Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reproductive Sciences, 19(12), 1302-1314. DOI Scopus31 WoS25 Europe PMC24
2012	Noll, J., Williams, S., Purton, L., & Zannettino, A. (2012). Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?. Blood Cancer Journal, 2(9), 1-10. DOI Scopus50 WoS43 Europe PMC44
2012	Fitter, S., Vandyke, K., Gronthos, S., & Zannettino, A. (2012). Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion. Journal of Molecular Endocrinology, 48(3), 229-240. DOI Scopus55 WoS46 Europe PMC53
2012	Ghosh, P., Moore, R., Vernon-Roberts, B., Goldschlager, T., Pascoe, D., Zannettino, A., . . . Itescu, S. (2012). Immunoselected STRO-3⁺ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs: Laboratory investigation. Journal of Neurosurgery: Spine, 16(5), 479-488. DOI Scopus80 WoS68 Europe PMC52
2012	Pyragius, C., Georgiou, K., Foster, B., Zannettino, A., & Xian, C. (2012). Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone, 50(5), 1081-1091. DOI Scopus51 WoS39 Europe PMC40
2012	Weber, B., Emmert, M., Behr, L., Schoenauer, R., Brokopp, C., Drogemuller, C., . . . Hoerstrup, S. (2012). Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials, 33(16), 4031-4043. DOI Scopus75 WoS58 Europe PMC47
2012	Cakouros, D., Isenmann, S., Cooper, L., Zannettino, A., Anderson, P., Glackin, C., & Gronthos, S. (2012). Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells. Molecular and Cellular Biology, 32(8), 1433-1441. DOI Scopus106 WoS93 Europe PMC84
2012	Crotti, T., Dharmapatni, A., Alias, E., Zannettino, A., Smith, M., & Haynes, D. (2012). The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Research & Therapy, 14(6), 1-13. DOI Scopus47 WoS40 Europe PMC35
2011	Andersen, D., Kortesidis, A., Zannettino, A., Kratchmarova, I., Chen, L., Jensen, O., . . . Kassem, M. (2011). Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells. Molecules and Cells, 32(2), 133-142. DOI Scopus12 WoS10 Europe PMC9
2011	Vandyke, K., Fitter, S., & Zannettino, A. (2011). The tyrosine kinase inhibitor dasatinib (SPRYCEL) inhibits chondrocyte activity and proliferation. Blood Cancer Journal, 1(2), E2. DOI Scopus22 WoS21 Europe PMC10
2011	Freeman, L., Lam, A., Petcu, E., Smith, R., Salajegheh, A., Diamond, P., . . . Vuckovic, S. (2011). Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8⁺CD4⁺ T cells: evidence from myeloma-bearing mouse model. Journal of Immunology, 187(8), 3987-3996. DOI Scopus8 WoS8 Europe PMC7
2011	Martin, S., Diamond, P., Gronthos, S., Peet, D., & Zannettino, A. (2011). The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. Leukemia, 25(10), 1533-1542. DOI Scopus108 WoS93 Europe PMC90
2011	Nath, S., Nicholson, I., Tapp, H., Zola, H., Zannettino, A., & Revesz, T. (2011). Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia. Medical Hypotheses, 77(3), 333-335. DOI Scopus8 WoS8 Europe PMC6
2011	Dharmapatni, A., Smith, M., Crotti, T., Holding, C., Vincent, C., Weedon, H., . . . Haynes, D. (2011). TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Research & Therapy, 13(2), R51-1-R51-10. DOI Scopus38 WoS31 Europe PMC30
2011	Field, J., Mc Gee, M., Stanley, R., Ruthenbeck, G., Papadimitrakis, T., Zannettino, A., . . . Itescu, S. (2011). The efficacy of allogeneic mesenchymal precursor cells for the repair of an ovine tibial segmental defect. Veterinary and Comparative Orthopaedics and Traumatology, 24(2), 113-121. DOI Scopus37 WoS40 Europe PMC28
2011	Arthur, A., Zannettino, A., Panagopoulos, R., Koblar, S., Sims, N., Stylianou, C., . . . Gronthos, S. (2011). EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation. Bone, 48(3), 533-542. DOI Scopus77 WoS70 Europe PMC66
2011	See, F., Seki, T., Psaltis, P., Sondermeijer, H., Gronthos, S., Zannettino, A., . . . Itescu, S. (2011). Therapeutic Effects of Human STRO-3-Selected Mesenchymal Precursor Cells and their Soluble Factors in Experimental Myocardial Ischemia. Journal of Cellular and Molecular Medicine, 15(10), 2117-2129. DOI Scopus51 WoS42 Europe PMC41
2011	Engler, J., Zannettino, A., Bailey, C., Rasko, J., Hughes, T., & White, D. (2011). OCT-1 function varies with cell lineage but is not influenced by BCR-ABL. Haematologica: the haematology journal, 96(2), 1-33. DOI Scopus13 WoS12 Europe PMC12
2011	Goldschlager, T., Ghosh, P., Zannettino, A., Williamson, M., Rosenfeld, J., Itescu, S., & Jenkin, G. (2011). A Comparison of mesenchymal precursor cells and amnion epithelial cells for enhancing cervical interbody fusion in an ovine model. Neurosurgery, 68(4), 1025-1034. DOI Scopus21 WoS20 Europe PMC20
2011	Zinonos, I., Labrinidis, A., Lee, M., Liapis, V., Hay, S., Ponomarev, V., . . . Evdokiou, A. (2011). Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo. Journal of Bone and Mineral Research, 26(3), 630-643. DOI Scopus19 WoS18 Europe PMC17
2011	Psaltis, P., Carbone, A., Leong, D., Lau, D., Nelson, A., Kuchel, T., . . . Worthley, S. (2011). Assessment of myocardial fibrosis by endoventricular electromechanical mapping in experimental nonischemic cardiomyopathy. International Journal of Cardiovascular Imaging, 27(1), 25-37. DOI Scopus32 WoS28 Europe PMC26
2010	Goldschlager, T., Ghosh, P., Zannettino, A., Gronthos, S., Rosenfeld, J., Itescu, S., & Jenkin, G. (2010). Cervical motion preservation using mesenchymal progenitor cells and pentosan polysulfate, a novel chondrogenic agent: preliminary study in an ovine model. Neurosurgical Focus, 28(6), E4-1-E4-8. DOI Scopus31 WoS23 Europe PMC18
2010	Ghosh, P., Wu, J., Shimmon, S., Zannettino, A., Gronthos, S., & Itescu, S. (2010). Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells. Arthritis Research & Therapy, 12(1), R28-1-R28-17. DOI Scopus47 WoS39 Europe PMC35
2010	Martin, S., Diamond, P., Williams, S., To, L., Peet, D., Fujii, N., . . . Zannettino, A. (2010). Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica, 95(5), 776-784. DOI Scopus83 WoS73 Europe PMC58
2010	Psaltis, P., Paton, S., See, F., Arthur, A., Martin, S., Itescu, S., . . . Zannettino, A. (2010). Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations. Journal of Cellular Physiology, 223(2), 530-540. DOI Scopus132 WoS115 Europe PMC104
2010	Engler, J., Frede, A., Saunders, V., Zannettino, A., Hughes, T., & White, D. (2010). Chronic Myeloid Leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 Activity. Leukemia, 24(4), 765-770. DOI Scopus55 WoS52 Europe PMC44
2010	Vandyke, K., Fitter, S., Dewar, A., Hughes, T., & Zannettino, A. (2010). Dysregulation of bone remodeling by imatinib mesylate. Blood, 115(4), 766-774. DOI Scopus127 WoS107 Europe PMC88
2010	Psaltis, P., Zannettino, A., Gronthos, S., & Worthley, S. (2010). Intramyocardial navigation and mapping for stem cell delivery. Journal of Cardiovascular Translational Research, 3(2 Sp Iss), 135-146. DOI Scopus28 WoS23 Europe PMC18
2010	Vandyke, K., Dewar, A., Diamond, P., Fitter, S., Schultz, C., Sims, N., & Zannettino, A. (2010). The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo. Journal of Bone and Mineral Research, 25(8), 1759-1770. DOI Scopus86 WoS73 Europe PMC66
2010	Zannettino, A., Paton, S., Itescu, S., & Gronthos, S. (2010). Comparative assessment of the osteoconductive properties of different biomaterials in vivo seeded with human or ovine mesenchymal stem/stromal cells. Tissue Engineering. Part A. Tissue Engineering, 16(12), 3579-3587. DOI Scopus32 WoS29 Europe PMC25
2010	McCarty, R., Xian, C., Gronthos, S., Zannettino, A., & Foster, B. (2010). Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury. The Open Orthopaedics Journal, 4(1), 220-226. DOI Scopus39 Europe PMC39
2010	Engler, J., Frede, A., Saunders, V., Zannettino, A., White, D., & Hughes, T. (2010). The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34⁺ cells. Blood, 116(15), 2776-2778. DOI Scopus20 WoS18 Europe PMC14
2010	Martin, S., Fitter, S., Bong, L., Drew, J., Gronthos, S., Shepherd, P., & Zannettino, A. (2010). NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. Journal of Bone and Mineral Research, 25(10), 2126-2137. DOI Scopus53 WoS51 Europe PMC45
2010	Psaltis, P., Carbone, A., Nelson, A., Lau, D., Jantzen, T., Manavis, J., . . . Worthley, S. (2010). Reparative effects of allogeneic mesenchymal precursor cells delivered transendocardially in experimental nonischemic cardiomyopathy. JACC: Cardiovascular Interventions, 3(9), 974-983. DOI Scopus63 WoS52 Europe PMC49
2010	Menicanin, D., Bartold, P., Zannettino, A., & Gronthos, S. (2010). Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues. Stem Cells and Development, 19(10), 1501-1510. DOI Scopus73 WoS58 Europe PMC52
2010	Fitter, S., Vandyke, K., Schultz, C., White, D., Hughes, T., & Zannettino, A. (2010). Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: A mechanism for improved insulin sensitivity in Type 2 diabetic CML patients?. Journal of Clinical Endocrinology and Metabolism, 95(8), 3763-3767. DOI Scopus50 WoS46 Europe PMC43
2010	Winkler, I., Barbier, V., Wadley, R., Zannettino, A., Williams, S., & Levesque, J. (2010). Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood, 116(3), 375-385. DOI Scopus199 WoS181 Europe PMC161
2010	Williams, S., Martin, S., Vincent, C., Gronthos, S., Zheng, T., Atkins, G., & Zannettino, A. (2010). Circulating levels of TWEAK correlate with bone erosion in multiple myeloma patients. British Journal of Haematology, 150(3), 373-376. DOI Scopus6 WoS6 Europe PMC4
2010	Castrechini, N., Murthi, P., Gude, N., Erwich, J., Gronthos, S., Zannettino, A., . . . Kalionis, B. (2010). Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta, 31(3), 203-212. DOI Scopus136 WoS116 Europe PMC95
2009	Isenmann, S., Arthur, A., Zannettino, A., Turner, J., Shi, S., Glackin, C., & Gronthos, S. (2009). TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem Cells, 27(10), 2457-2468. DOI Scopus177 WoS166 Europe PMC149
2009	Gronthos, S., McCarty, R., Mrozik, K., Fitter, S., Paton, S., Menicanin, D., . . . Zannettino, A. (2009). Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: Generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues. Stem Cells and Development, 18(9), 1253-1261. DOI Scopus71 WoS61 Europe PMC49
2009	Zinonos, I., Labrinidis, A., Lee, M., Liapis, V., Hay, S., Ponomarev, V., . . . Evdokiou, A. (2009). Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer. Molecular Cancer Therapeutics, 8(10), 2969-2980. DOI Scopus37 WoS38 Europe PMC33
2009	Arthur, A., Shi, S., Zannettino, A., Fujii, N., Gronthos, S., & Koblar, S. (2009). Implanted adult human dental pulp stem cells induce endogenous axon guidance. Stem Cells, 27(9), 2229-2237. DOI Scopus129 WoS118 Europe PMC100
2009	Paquet- Fifield, S., Schluter, H., Li, A., Aitken, T., Gangatirkar, P., Blashki, D., . . . Kaur, P. (2009). A role for pericytes as microenvironmental regulators of human skin tissue regeneration. Journal of Clinical Investigation, 119(9), 2795-2806. DOI Scopus181 WoS161 Europe PMC134
2009	Vandyke, K., Dewar, A., Menicanin, D., To, L., Hughes, T., Zannettino, A., & Fitter, S. (2009). Imatinib mesylate causes growth plate closure in vivo. Leukemia, 23(11), 2155-2159. DOI Scopus37 WoS32 Europe PMC34
2009	Diamond, P., Labrinidis, A., Martin, S., Farrugia, A., Gronthos, S., To, L., . . . Zannettino, A. (2009). Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss. Journal of Bone and Mineral Research, 24(7), 1150-1161. DOI Scopus60 WoS61 Europe PMC46
2009	Dickinson, M., Prince, H., Kirsa, S., Zannettino, A., Gibbs, S., Mileshkin, L., . . . Joshua, D. (2009). Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for prevention and treatment. Internal Medicine Journal, 39(5), 304-316. DOI Scopus42 WoS38 Europe PMC28
2009	Vandyke, K., Dewar, A., Farrugia, A., Fitter, S., To, B., Hughes, T., & Zannettino, A. (2009). Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia, 23(5), 994-997. DOI Scopus49 WoS47 Europe PMC39
2009	Menicanin, D., Bartold, P., Zannettino, A., & Gronthos, S. (2009). Genomic Profiling of Mesenchymal Stem Cells. Stem Cell Reviews, 5(1), 36-50. DOI Scopus70 WoS61 Europe PMC44
2009	Chung, R., Foster, B., Zannettino, A., & Xian, C. (2009). Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate. Bone, 44(5), 878-885. DOI Scopus61 WoS52 Europe PMC40
2009	Mc Carty, R., Gronthos, S., Zannettino, A., Foster, B., & Xian, C. (2009). Characterisation and Developmental Potential of Ovine Bone Marrow Derived Mesenchymal Stem Cells. Journal of Cellular Physiology, 219(2), 324-333. DOI Scopus134 WoS116 Europe PMC96
2009	Labrinidis, A., Diamond, P., Martin, S., Hay, S., Liapis, V., Zinonos, I., . . . Evdokiou, A. (2009). Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma. Clinical Cancer Research, 15(6), 1998-2009. DOI Scopus33 WoS30 Europe PMC28
2009	Arthur, A., Zannettino, A., & Gronthos, S. (2009). The Therapeutic Applications of Multipotential Mesenchymal/Stromal Stem Cells in Skeletal Tissue Repair. Journal of Cellular Physiology, 218(2), 237-245. DOI Scopus291 WoS253 Europe PMC196
2009	Psaltis, P. J., Carbone, A., Lau, D., Jantzen, T., Williams, K., Sanders, P., . . . Worthley, S. G. (2009). Purkinje fiber injury and electrical remodeling in non-ischemic cardiomyopathy: Implications for sudden cardiac death. EUROPEAN HEART JOURNAL, 30, 558.
2009	Psaltis, P. J., See, F., Paton, S., Martens, T. P., Itescu, S., Worthley, S. G., . . . Zannettino, A. C. W. (2009). STRO-1 immunoselection enhances the biological properties and cardiovascular paracrine effects of bone marrow mesenchymal stromal cells. EUROPEAN HEART JOURNAL, 30, 501.
2008	Zannettino, A., Paton, S., Kortesidis, A., Khor, F., Itescu, S., & Gronthos, S. (2008). Human mulipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright/CD34-/CD45-/glycophorin-A-bone marrow cells. Haematologica, 92(12), 1707-1708. DOI Scopus75 WoS66 Europe PMC52
2008	Psaltis, P., Carbone, A., Nelson, A., Lau, D., Manavis, J., Finnie, J., . . . Worthley, S. (2008). An ovine model of toxic, nonischemic cardiomyopathy-assessment by cardiac magnetic resonance imaging. Journal of Cardiac Failure, 14(9), 785-795. DOI Scopus25 WoS18 Europe PMC14
2008	Labrinidis, A., Liapis, V., Thai, L., Atkins, G., Vincent, C., Hay, S., . . . Evdokiou, A. (2008). Does Apo2LTRAIL play any physiologic role in osteoclastogenesis?. Blood, 111(11), 5411-5412. DOI Scopus19 WoS15 Europe PMC10
2008	Psaltis, P., Zannettino, A., Worthley, S., & Gronthos, S. (2008). Concise review: Mesenchymal stromal cells: Potential for cardiovascular repair. Stem Cells, 26(9), 2201-2210. DOI Scopus303 WoS257 Europe PMC215
2008	Zannettino, A., Psaltis, P., & Gronthos, S. (2008). Home is where the heart is: Via the FROUNT. Cell Stem Cell, 2(6), 513-514. DOI Scopus1 WoS1 Europe PMC1
2008	Fitter, S., Dewar, A., Kostakis, P., To, L., Hughes, T., Roberts, M., . . . Zannettino, A. (2008). Long-term imatinib therapy promotes bone formation in CML patients. Blood, 111(5), 2538-2547. DOI Scopus146 WoS129 Europe PMC116
2008	Zannettino, A., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J., & Gronthos, S. (2008). Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. Journal of Cellular Physiology, 214(2), 413-421. DOI Scopus482 WoS417 Europe PMC361
2007	Gronthos, S., Fitter, S., Diamond, P., Simmons, P., Itescu, S., & Zannettino, A. (2007). A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells. Stem Cells and Development, 16(6), 953-963. DOI Scopus104 WoS95 Europe PMC80
2007	White, D., Saunders, V., Dang, P., Engler, J., Venables, A., Zrim, S., . . . Hughes, T. (2007). Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood, 110(12), 4064-4072. DOI Scopus280 WoS255 Europe PMC219
2007	Isenmann, S., Cakouros, D., Zannettino, A., Shi, S., & Gronthos, S. (2007). hTERT Transcription is repressed by Cbfa1 in human mesenchymal stem cell populations. Journal of Bone and Mineral Research, 22(6), 897-906. DOI Scopus24 WoS22 Europe PMC15
2007	Atkins, G., Anderson, P., Findlay, D., Welldon, K., Vincent, C., Zannettino, A., . . . Morris, H. (2007). Metabolism of vitamin D₃ in human osteoblasts: Evidence for autocrine and paracrine activities of 1α,25-dihydroxyvitamin D₃. Bone, 40(6), 1517-1528. DOI Scopus226 WoS188 Europe PMC162
2007	Gronthos, S., & Zannettino, A. (2007). The role of the chemokine CXCL12 in osteoclastogenesis. Trends in Endocrinology and Metabolism, 18(3), 108-113. DOI Scopus51 WoS41 Europe PMC33
2006	Gronthos, S., & Zannettino, A. (2006). Potential of bone marrow stromal stem cells to repair bone defects and fractures. Journal of Stem Cells, 1(1), 35-45. Scopus3
2006	Tsangari, H., Findlay, D., Zannettino, A., Pan, B., Kuliwaba, J., & Fazzalari, N. (2006). Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients. Bone, 39(6), 1226-1235. DOI Scopus19 WoS19 Europe PMC16
2006	Martin, S., Dewar, A., Farrugia, A., Horvath, N., Gronthos, S., To, L., & Zannettino, A. (2006). Tumor angiogenesis is associated with plasma levels of stromal-derived factor-1α in patients with multiple myeloma. Clinical Cancer Research, 12(23), 6973-6977. DOI Scopus33 WoS30 Europe PMC22
2006	Atkins, G., Kostakis, P., Vincent, C., Farrugia, A., Houchins, J., Findlay, D., . . . Zannettino, A. (2006). RANK expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone. Journal of Bone and Mineral Research, 21(9), 1339-1349. DOI Scopus115 WoS103 Europe PMC95
2006	White, D., Saunders, V., Dang, P., Engler, J., Zannettino, A., Cambareri, A., . . . Hughes, T. (2006). OCT-1-mediated influx is a key determinant of the intraceflular uptake of imatinib but not nilotinib, (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood, 108(2), 697-704. DOI Scopus387 WoS322 Europe PMC269
2006	Dewar, A., Farrugia, A., Condina, M., To, L., Hughes, T., Vernon-Roberts, B., & Zannettino, A. (2006). Imatinib as a potential antiresorptive therapy for bone disease. Blood, 107(11), 4334-4337. DOI Scopus70 WoS65 Europe PMC57
2006	Martens, T., See, F., Shuster, M., Sondermeijer, H., Hefti, M., Zannettino, A., . . . Itescu, S. (2006). Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium. Nature Clinical Practice Cardiovascular Medicine, 3(Suppl 1), 18-22. DOI Scopus101 Europe PMC66
2005	Dewar, A., Zannettino, A., Hughes, T., & Lyons, A. (2005). Inhibition of c-fms by imatinib - Expanding the spectrum of treatment. Cell Cycle, 4(7), 851-853. DOI Scopus46 WoS45 Europe PMC38
2005	Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., . . . Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. DOI Scopus144 WoS141 Europe PMC103
2005	Dewar, A., Cambareri, A., Zannettino, A., Boog, B., Doherty, K., Hughes, T., & Lyons, A. (2005). Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood, 105(8), 3127-3132. DOI Scopus273 WoS248 Europe PMC198
2005	Atkins, G., Kostakis, P., Welldon, K., Vincent, C., Findlay, D., & Zannettino, A. (2005). Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium. Journal of Cellular Physiology, 203(3), 573-582. DOI Scopus30 WoS29 Europe PMC27
2005	Kortesidis, A., Zannettino, A., Isenmann, S., Shi, S., Lapidot, T., & Gronthos, S. (2005). Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood, 105(10), 3793-3801. DOI Scopus338 WoS317 Europe PMC265
2005	Zannettino, A., Farrugia, A., Kortesidis, A., Manavis, J., To, L., Martin, S., . . . Gronthos, S. (2005). Elevated serum levels of stromal-derived factor-1α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Research, 65(5), 1700-1709. DOI Scopus184 WoS165 Europe PMC132
2004	Zannettino, A., Pan, B., Farrugia, A., Atkins, G., & To, L. (2004). Identification and clinical relevance of receptor activator of nuclear factor kappa B ligand expression of myeloma cells - Reply. Cancer Research, 64(2), 774-775.
2004	Martin, S., To, L., Horvath, N., & Zannettino, A. (2004). Angiogenesis in multiple myeloma: Implications in myeloma therapy. Cancer Reviews: Asia-Pacific, 2(2), 119-129. DOI
2004	Findlay, D., Welldon, K., Atkins, G., Howie, D., Zannettino, A., & Bobyn, D. (2004). The proliferation and phenotypic expression of human osteoblasts on tantalum metal. Biomaterials, 25(12), 2215-2227. DOI Scopus193 WoS161 Europe PMC88
2004	Pan, B., To, L., Farrugia, A., Findlay, D., Green, J., Gronthos, S., . . . Zannettino, A. (2004). The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone, 34(1), 112-123. DOI Scopus104 WoS91 Europe PMC71
2004	Pan, B., Farrugia, A., To, L., Findlay, D., Green, J., Lynch, K., & Zannettino, A. (2004). The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). Journal of Bone and Mineral Research, 19(1), 147-154. DOI Scopus147 WoS129 Europe PMC110
2004	Hu, Y., Zhou, H., Myers, D., Quinn, J., Atkins, G., Ly, C., . . . Ng, K. (2004). Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. Journal of Bone and Mineral Research, 19(1), 89-99. DOI Scopus45 WoS39 Europe PMC36
2003	Zannettino, A., Roubelakis, M., Welldon, K., Jackson, D., Simmons, P., Bendall, L., . . . Watt, S. (2003). Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Biochemical Journal, 370(2), 537-549. DOI Scopus32 WoS31 Europe PMC30
2003	Zannettino, A., Harrison, K., Joyner, C., Triffitt, J., & Simmons, P. (2003). Molecular cloning of the cell surface antigen identified by the osteoprogenitor-specific monoclonal antibody, HOP-26. Journal of Cellular Biochemistry, 89(1), 56-66. DOI Scopus37 WoS33 Europe PMC27
2003	Bendall, L., James, A., Zannettino, A., Simmons, P., Gottlieb, D., & Bradstock, K. (2003). A novel CD44 antibody identifies an epitope that is aberrantly expressed on acute lymphoblastic leukaemia cells. Immunology and Cell Biology, 81(4), 311-319. DOI Scopus5 WoS4 Europe PMC4
2003	Haynes, D., Barg, E., Crotti, T., Holding, C., Weedon, H., Atkins, G., . . . Smith, M. (2003). Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls. Rheumatology, 42(1), 123-134. DOI Scopus136 WoS122 Europe PMC96
2003	Gronthos, S., Zannettino, A., Hay, S., Shi, S., Graves, S., Kortesidis, A., & Simmons, P. (2003). Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. Journal of Cell Science, 116(9), 1827-1835. DOI Scopus943 WoS805
2003	Atkins, G., Kostakis, P., Pan, B., Farrugia, A., Gronthos, S., Evdokiou, A., . . . Zannettino, A. (2003). RANKL expression is related to the differentiation state of human osteoblasts. Journal of Bone and Mineral Research, 18(6), 1088-1098. DOI Scopus218 WoS194 Europe PMC164
2003	Farrugia, A., Atkins, G., To, L., Pan, B., Horvath, N., Kostakis, P., . . . Zannettino, A. (2003). Receptor activator of nuclear factor-kB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Research, 63(17), 5438-5445. Scopus201 WoS185 Europe PMC148
2003	Zhang, X., Fitzsimmons, R., Cleland, L., Ey, P., Zannettino, A., Farmer, E., . . . Mayrhofer, G. (2003). CD36/fatty acid translocase in rats: Distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1. Laboratory Investigation, 83(3), 317-332. DOI Scopus59 WoS51 Europe PMC40
2003	Gronthos, S., Zannettino, A. C., Hay, S. J., Shi, S., Graves, S. E., Kortesidis, A., & Simmons, P. J. (2003). Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.. Journal of cell science, 116(Pt 9), 1827-1835. DOI Europe PMC669
2003	Pan, B., To, L., Farrugia, A., Kostakis, P., Atkins, G., Findlay, D., & Zannettino, A. (2003). Multiple myeloma-derived pro-inflammatory cytokines enhance osteoclastogenesis by increasing the number of RANKL-expressing STRO-1 positive osteoprogenitor cells. Blood, 102(11), 5207.
2002	Atkins, G., Bouralexis, S., Evdokiou, A., Hay, S., Labrinidis, A., Zannettino, A., . . . Findlay, D. (2002). Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Bone, 31(4), 448-456. DOI Scopus60 WoS60 Europe PMC42
2002	Atkins, G., Haynes, D., Zannettino, A., Capone, M., Crotti, T., & Findlay, D. (2002). Haemopoietic cells influence stromal cell gene expression during human osteoclast development. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 235.
2001	Atkins, G., Bouralexis, S., Haynes, D., Graves, S., Geary, S., Evdokiou, A., . . . Findlay, D. (2001). Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone. Bone, 28(4), 370-377. DOI Scopus86 WoS82 Europe PMC64
1999	Levesque, J. P., Zannettino, A., Pudney, M., Niutta, S., Haylock, D., Snapp, K., . . . Simmons, P. (1999). PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in supression of hematopoiesis. Immunity, 11(3), 369-378. DOI Scopus101 WoS94 Europe PMC73
1999	Gronthos, S., Zannettino, A., Graves, S., Ohta, S., Hay, S., & Simmons, P. (1999). Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells. Journal of Bone and Mineral Research, 14(1), 47-56. DOI Scopus250 WoS230 Europe PMC189
1998	Filshie, R. J. A., Zannettino, A. C. W., Makrynikola, V., Gronthos, S., Henniker, A. J., Bendall, L. J., . . . Bradstock, K. F. (1998). MUC18, a member of the immunoglobulin superfamily, is expressed on bone marrow fibroblasts and a subset of hematological malignancies. Leukemia, 12(3), 414-421. DOI Scopus78 WoS68 Europe PMC61
1997	Siminons, P., Gronthos, S., Zannettino, A., & Graves, S. (1997). Cell surface antigens expressed by bone marrow stromal cell precursors. Experimental Hematology, 25(8), 736.
1997	Zannettino, A., Aylett, G., Leavesley, D., Pietsch, T., Chang, D., Simmons, P., & Ashman, L. (1997). Specificity and functional effects of antibodies to human stem cell factor. Growth Factors, 14(1), 67-79. DOI Scopus5 WoS5 Europe PMC5
1996	Zannettino, A., Rayner, J., Ashman, L., Gonda, T., & Simmons, P. (1996). A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning. Journal of Immunology, 156(2), 611-620. Scopus41 WoS41 Europe PMC23
1995	Zannettino, A., Berndt, M., Nuitta, S., Butcher, C., Vadas, M., & Simmons, P. (1995). Primitive human haemopoietic progenitors adhere to P-selectin (CD62P). Blood, 85(12), 3466-3477. DOI Scopus83 WoS85 Europe PMC43
1994	Simmons, P. J., Gronthos, S., Zannettino, A., Ohta, S., & Graves, S. (1994). Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis.. Progress in clinical and biological research, 389, 271-280. Scopus72 Europe PMC38
1994	Simmons, P. J., Zannettino, A., Gronthos, S., & Leavesley, D. (1994). Potential adhesion mechanisms for localisation of haemopoietic progenitors to bone marrow stroma. Leukemia and Lymphoma, 12(5-6), 353-363. DOI Scopus98 WoS98 Europe PMC47

Book Chapters

Year	Citation
2011	Gronthos, S., & Zannettino, A. (2011). Methods for the purification and characterization of human adipose-derived stem cells.. In J. Gimble, & B. Bunnell (Eds.), Methods in Molecular Biology: Adipose-Derived Stem Cells - Methods and Protocols (Vol. 702, 1 ed., pp. 109-120). USA: Humana Press. DOI Scopus20 Europe PMC17
2008	Gronthos, S., & Zannettino, A. (2008). A method to isolate and purify human bone marrow stromal stem cells. In D. Prockop, D. Phinney, & B. Bunnell (Eds.), Mesenchymal Stem Cells: Methods and Protocols (Vol. 449, pp. 45-57). United States: Humana Press. DOI Scopus53 Europe PMC37
2008	Gronthos, S., & Zannettino, A. (2008). Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures. In P. Koka (Ed.), Progress in Stem Cell Research (pp. 47-62). New York: Nova Science Publishers.
2005	Zannettino, A., Farrugia, A., To, L., & Atkins, G. (2005). An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors. In R. Brown, & P. Joy Ho (Eds.), Multiple Myeloma: Methods and Protocols (Vol. 113, pp. 245-256). Totowa, New Jersey: Humana Press. DOI Scopus3

Conference Papers

Year	Citation
2014	Vandyke, K., Mrozik, K. M., Cheong, C. M., Chow, A. W. S., Kok, C. H., Blaschuk, O., . . . Zannettino, A. C. W. (2014). Identification of an Epithelial-to-Mesenchymal Transition (EMT)-like Programme in t(4;14)-Positive Multiple Myeloma Reveals Novel Targets for Therapeutic Intervention. In BLOOD Vol. 124 (pp. 3 pages). San Francisco, CA: AMER SOC HEMATOLOGY. WoS1
2011	Zinonos, I., Labrinidis, A., Liapis, V., Hay, S., Diamond, P., Findlay, D., . . . Evdokiou, A. (2011). Local production of osteoprotegerin by breast cancer cells inhibits cancer-induced osteolysis and intra-osseous tumour burden but fails to restrain extra-medullary tumour growth. In BONE Vol. 48 (pp. S256). Athens, GREECE: ELSEVIER SCIENCE INC. DOI
2010	Nath, S. V., Tamblyn, M., Telfer, S., Henwood, T., Gilham, P., Story, C., . . . Revesz, T. (2010). Ethylene Diamine Tetra Acetic Acid (EDTA) Decalcification of Paediatric Bone Marrow Trephines In a Diagnostic Laboratory. In BLOOD Vol. 116 (pp. 1062). Orlando, FL: AMER SOC HEMATOLOGY. WoS1
2009	McCarty, R. C., Gronthos, S., Zannettino, A. C., Foster, B. K., & Xian, C. J. (2009). Characterisation of ovine bone marrow derived mesenchymal stromal/stem cells and autologous application to growth plate cartilage defect. In BONE Vol. 45 (pp. S106-S107). Cambridge, ENGLAND: ELSEVIER SCIENCE INC. DOI
2009	McCarty, R. C., Gronthos, S., Zannettino, A. C., Foster, B. K., & Xian, C. J. (2009). Characterisation of ovine bone marrow derived mesenchymal stem cells and autologous application to growth plate cartilage defect. In BONE Vol. 44 (pp. S159). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI
2009	Macsai, C., Hopwood, B., Zannettino, A. C., Scherer, M. A., Foster, B. K., & Xian, C. J. (2009). Micro-CT and micro-array analyses of growth plate cartilage injury responses and bony repair. In BONE Vol. 44 (pp. S152). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI
2009	Psaltis, P. J., Worthley, S. G., See, F., Itescu, S., Martens, T., Gronthos, S., & Zannettino, A. (2009). Enrichment for Stro-1 Enhances Paracine-mediated Cardiovascular Repair From Human Bone Marrow Mesenchymal Cells. In CIRCULATION Vol. 120 (pp. S821). Orlando, FL: LIPPINCOTT WILLIAMS & WILKINS.
2009	Zinonos, I., Labrinidis, A., Liapis, V., Hay, S., Lee, M., Ponomarev, V., . . . Evdokiou, A. (2009). Apomab, a fully human agonistic DR5 monoclonal antibody inhibits tumour growth and osteolysis in murine models of breast cancer development and progression. In BONE Vol. 44 (pp. S54). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI
2009	Psaltis, P. J., Carbone, A., Manavis, J., Jantzen, T., Lau, D., Sanders, P., . . . Worthley, S. G. (2009). Catheter-based Electromechanical Mapping Accurately Characterizes Segmental Distribution of Left Ventricular Fibrosis in Nonischemic Cardiomyopathy. In CIRCULATION Vol. 120 (pp. S906). Orlando, FL: LIPPINCOTT WILLIAMS & WILKINS.
2009	Psaltis, P. J., Zannettino, A., Carbone, A., Manavis, J., Williams, K., Jantzen, T., . . . Worthley, S. G. (2009). Cardiac Repair With Transendocardial Injection of Allogeneic Mesenchymal Precursor Cells for Nonischemic Cardiomyopathy. In CIRCULATION Vol. 120 (pp. S827). Orlando, FL: LIPPINCOTT WILLIAMS & WILKINS.
2008	Diamond, P., Labrinidis, A., Martin, S. K., Gronthos, S., To, L., Fuji, N., . . . Zannettino, A. C. W. (2008). Elevated Serum Levels of CXCL12 Is Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 23 (pp. S262). Montreal, CANADA: AMER SOC BONE & MINERAL RES.
2008	Vandyke, K., Dewar, A., Diamond, P., Fitter, S., Farrugia, A. N., To, L. B., . . . Zannettino, A. C. W. (2008). Dasatinib (Sprycel™) Inhibits Oteoclast Activity <i>in Vitro</i> and <i>in Vivo</i> Via a C-Fms-Dependent and C-Src-Independent Mechanism. In BLOOD Vol. 112 (pp. 1102-1103). San Francisco, CA: AMER SOC HEMATOLOGY.
2005	Kostakis, P., Atkins, G., Vincent, C., Farrugia, A., Findlay, D., Evdokiou, A., & Zannettino, A. (2005). RANK expression in normal and malignant cells: a monoclonal antibody study. In Journal of Bone and Mineral Research Vol. 20 (pp. SA-259.). Nashville, Tennessee: American Society for Bone and Mineral Research.
2004	Atkins, G., Anderson, P., Welldon, K., Zannettino, A., Morris, H., & Findlay, D. (2004). Vitamin D metabolism in human osteoblasts. In Journal of Bone and Mineral Research Vol. 19 (pp. SA-587). Seattle, Washington: American Society for Bone and Mineral Research.
2003	Kostakis, P., Atkins, G., Pan, B., Farrugia, A., Gronthos, S., Evdokiou, A., . . . Zannettino, A. (2003). The relationship between RANKL expression and osteoblast differentiation in human osteoblasts. In 30th European Symposium on Calcified Tissues, 8-12 May 2003 Vol. Italy (pp. 314-468). Rome, Italy: Springer Science and Business Media LLC. DOI
2002	Atkins, G., Zannettino, A., Kostakis, P., Pan, B., Farrugia, A., Evdokiou, A., & Findlay, D. (2002). Evidence for the maturation-dependent expression of an osteoclastogenic phenotype in human osteoblasts.. In Journal of Bone and Mineral Research Vol. 17 (pp. S446.). San Antonio, Texas: American Society for Bone and Mineral Research.
2002	Atkins, G., Pan, B., Findlay, D., To, L., Evdokiou, A., Labrinidis, A., . . . Zannettino, A. (2002). Zoledronate is anabolic for human osteoblast-like cells. In Journal of Bone and Mineral Research Vol. 17 (pp. S442.). San Antonio, Texas: American Society for Bone and Mineral Research.

Conference Items

Year	Citation
2014	Cheung, K. C., Hewett, D., Yeung, D., Tan, C. W., To, L. B., & Zannettino, A. (2014). THE ROLE OF MERTK IN THE PROGRESSION OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) TO MYELOMA (MM). Poster session presented at the meeting of HAEMATOLOGICA. Milan, ITALY: FERRATA STORTI FOUNDATION.
2013	Dharmapatni, A., Coleman, R., Lorimer, M., Zannettino, A., Weedon, H., Wechalekar, M., . . . Crotti, T. (2013). Relationship between Soluble OSCAR and Disease Activity: A 12 Month Study of Newly Diagnosed RA Patients. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL.
2012	Crotti, T., Alias, E., Dharmapatni, A., Weedon, H., Zannettino, A., & Smith, M. (2012). EVIDENCE THAT VASCULAR EXPRESSION OF THE ITAM RECEPTOR, OSCAR, IN ACTIVE RHEUMATOID ARTHRITIS IS MODULATED BY INFLAMMATORY MEDIATORS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2008	Vandyke, K., Dewar, A. L., Davis, A. N., Fiuer, S., Hughes, T. P., To, L. B., & Zannettino, A. C. W. (2008). The tyrosine kinase inhibitor dasatinib decreases osteoclast formation and activity in vitro. Poster session presented at the meeting of 30th Annual Meeting of the American Society for Bone and Mineral Research, as published in Journal of Bone and Mineral Research. Montreal, Canada: Wiley. DOI
2003	Atkins, G., Anderson, P., Morris, H., Zannettino, A., Kostakis, P., & Findlay, D. (2003). The expression of 25-hydroxyvitaminD 24-hydroxylase and 25-hydroxyvitaminD 1 alpha-hydroxylase in human osteoblasts. Poster session presented at the meeting of Journal of Bone Mineral Research. Minnesota, USA.
2003	Anderson, P., Atkins, G., Morris, H., Kostakis, P., Findlay, D., & Zannettino, A. (2003). The expression of 25-hydroxyvitaminD 24-hydroxylase and 25-hydroxyvitaminD 1 alpha-hydroxylase in human osteoblasts.. Poster session presented at the meeting of Calcified Tissue International. Rome, Italy: Springer.

Datasets

Year	Citation
2004	Hu, Y., Atkins, G., Zhou, H., Myers, D., Quinn, J., Ly, C., . . . Ng, K. (2004). NM_001004419 Homo sapiens C-type lectin domain family 2, member D (CLEC2D), transcript variant 2, mRNA.
2004	Hu, Y., Atkins, G., Zhou, H., Myers, D., Quinn, J., Ly, C., . . . Ng, K. (2004). NM_013269 Homo sapiens C-type lectin domain family 2, member D (CLEC2D), transcript variant 1, mRNA.

Research Funding

Since establishing my laboratory in 2000, I have been awarded in excess of AUD $35 million in funding. Of note, as a CI, I have been awarded a total of 22 NHMRC grants. In addition, I have been awarded competitive grants from Cancer Australia, Leukemia Lymphoma Society (US), Multiple Myeloma Research Foundation, Cancer Council, Australian Cancer Research Fund and the International Myeloma Foundation, as detailed below. Furthermore, I have received industry funding from sources including Mesoblast Ltd, Celgene, Novartis, Zimmer and Johnson & Johnson. A list of the NHMRC, ARC and other awarded grants are provided below.

**Summary of NHMRC Funding**
Grant Title	Funding	Initiative	Role	First Year Funded	Number of Years	Total Amount ($) of Grant
Bone marrow macrophages: “Resident Evil” in the establishment and progression of multiple myeloma	Research Support	Project Grant	CIA	2018	3	570,585.00
Myeloma Plasma Cell Dormancy - 'Eradicating the Sleeping Giant'	Research Support	Project Grant	CIB	2018	3	834,428.00
Tyrosine kinase receptor c-ros-oncogene 1 mediates Twist-1 haploinsufficiency induced craniosynostosis in children: A novel therapeutic target	Research Support	Project Grant	CIB	2017	3	562,863.00
Targeting skeletal mTORC1 as a novel approach for the treatment of diet-induced insulin resistance	Research Support	Project Grant	CIA	2016	3	586,979.00
Why is the bone marrow a “hot-spot” for myeloma plasma cell metastasis: are there Gremlins in the system?	Research Support	Project Grant	CIA	2016	3	651,979.00
The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis	Research Support	Project Grant	CIB	2015	3	548,347.00
Understanding clonal evolution in multiple myeloma	Research Support	Project Grant	CIA	2014	3	647,111.00
Twist-1 inhibits MSC osteoblast differentiation during osteoporosis	Research Support	Project Grant	CIB	2013	3	466,044.00
Is mTOR a novel target for the treatment of osteoporosis?	Research Support	Project Grant	CIA	2012	3	543,675.00
EphB-ephrinB mediates MSC bone regeneration	Research Support	Project Grant	CIB	2012	3	591,010.00
The Role of Hypoxia and Myeloma Disease Progression	Research Support	Project Grant	CIA	2010	3	594,582.00
Twist-1 Regulation of MSC Growth and Development	Research Support	Project Grant	CIB	2010	3	594,582.00
Novel strategies for the treatment of bone cancer	Research Support	Project Grant	CIC	2009	3	456,304.00
Control of premature bony fusion in skull development	Research Support	Project Grant	CIC	2008	3	555,855.00
Role of TWEAK in bone remodelling	Research Support	Project Grant	CIE	2007	3	566,947.00
The role of factors that regulate early processes of bone cell development	Research Support	Project Grant	CIB	2007	3	485,929.00
Chemokines and Myeloma Disease Progression	Research Support	Project Grant	CIA	2007	3	665,897.00
The role of human osteoblasts in osteoclast formation	Research Support	Project Grant	CIC	2004	3	436,450.00
Skeletal disease mediated by haematological malignancy	Research Support	Project Grant	CIA	2004	3	432,750.00
The cells and molecules involved in the formation and activity of human osteoclasts	Research Support	Project Grant	CID	2001	3	326,036.00
Drug resistance in leukaemia	Research Support	Project Grant	CIC	2001	3	362,545.00
The Molecular Mechanisms of Bone Destruction in Multiple Myeloma	Research Support	Project Grant	CIA	2001	3	212,036.00

Summary of Other Funding

Grant Title	Funding	Source	Role	First Year Funded	Number of Years	Total Amount ($) of Grant
Using novel high-precision proteomic analysis to discover biomarkers that identify smouldering myeloma patients at high-risk of progression to active multiple myeloma.	Research Support	Cancer Australia - Priority-Driven Collaborative Cancer Research	CIB	2020	2	199,720.00
Serum CTX-1 levels to predict smouldering myeloma patients at high-risk of progression to multiple myeloma: a prospective clinical trial	Research Support	Bone Health Foundation	CIB	2020	1	25,000.00
Targeting Macromolecule Biosynthesis in Cancer by in vivo Flux Measurement of Primary Cells for Rational Drug Development	Infrastructure Support	SAHMRI Beat Cancer - Project Infrastructure Grant	CID	2020	1	87,000.00
A new drug delivery system to improve the quality of life and survival of patients with the blood cancer multiple myeloma	Research Support	Tour De Cure –Early Career Research Grant	CIC	2020	1	50,000.00
N-cadherin inhibitors as vascular disrupting agents: increasing drug delivery to tumours and improving quality of life for cancer patients	Research Support	Cancer Australia - Priority-Driven Collaborative Cancer Research Scheme	CIB	2019	2	198,596.00
The Role of the Bone Marrow Microenvironment in Myeloma development	Research Support	Leukaemia Foundation - National Research Program	CIA	2019	3	596,199.00
Investigating the mechanisms by which bone-specific mTORC1 inhibition protects mice against diet-induced insulin resistance	Research Support	Diabetes Australia Research Trust	CIA	2019	1	60,000.00
ACRF Centre for Integrated Cancer Systems Biology	Infrastructure Support	Australian Cancer Research Fund	CIB	2019	1	2,500,000.00
Single cell sequencing to discover tumour-associated changes in the bone microenvironment of myeloma patients: identification of prognostic markers and novel therapeutic targets	Research Support - Brian D. Novis Senior Research Grant	International Myeloma Foundation	CIA	2019	1	110,000.00
Research Consortium Program for Agricultural Product Development	Research Support	Premier's Research and Industry Fund	CIB	2019	5	5,214,000.00
Stromal Cell-Derived Gremlin1 to Control Multiple Myeloma Disease	Research Support	Leukemia and Lymphoma Society	CIA	2018	3	780,000.00
The role of novel paediatric B-cell Acute Lymphoblastic Leukaemia (ALL) blast cell-derived factors on blast cell and stromal cell biology	Research Support	Women’s and Children’s Health Foundation	CIA	2017	2	201,412.00
Adelaide GSEx Flow Cytometry Facility	Infra-structure Support	Australian Research Council	CIC	2017	N/A	480,000.00
Mechanisms governing mobilisation and dissemination in multiple myeloma: the role of hypoxia and the CCR1/CXCR4 axis	Research Support	Cancer Australia - Priority-Driven Collaborative Cancer Research Scheme	CIB	2017	2	199,454.00
Localized treatment of solid tumours with cytotoxic T cells	Research Support	THRF - Project Grant	CIB	2017	1	125,000.00
Skeletal endocrine signalling in the regulation of glucose metabolism	Research Support	Australian Research Council	CIA	2016	3	379,400.00
Validation of a novel therapeutic target in multiple myeloma	Research Support	RAHRC - NHMRC Near Miss Grants	CIA	2016	1	100,000.00
A Tough Resilin based Hydrogel Platform for Repair and Regeneration	Research Support	Australian Research Council	CIB	2016	3	358,000.00
Bone Marrow Recovery in Acute Lymphoblastic Leukaemia	Research Support	Women’s and Children’s Health Foundation	CIA	2015	2	226,426.00
Cooperating genetic changes that drive MM development: the role of SAMSN1 and GLIPR1 tumour suppressor gene	Research Support	Cancer Council of South Australia	CIA	2015	1	75,000.00
Minimal residual disease (MRD) detection in Multiple Myeloma (MM) patients in complete remission post-autograft: correlation with risk of relapse?	Research Support	SA Pathology RAH Contributing Haematologists’ Committee Fund	CIB	2015	1	30,000.00
Understanding clonal evolution in multiple myeloma	Research Support	Ray and Shirl Norman Trust- HSCGB	CIA	2014	3	300,000.00
An improved technology for isolating human adult stem cells for regenerative therapies	Research Support	Adelaide Research and Innovation- Commercial Accelerator Scheme Fund	CIA	2013	1	100,000.00
Understanding the mechanisms of aberrant bone formation in Saethre-Chotzen syndrome patients with Twist-1 mutations	Research Support	Research, Robinson Institute Collaborative Grant	CIB	2013	1	65,000.00
South Australian Blood Cancer Tumour Bank	Infra-structure Support	SA Cancer Research, Medvet, Community donor	CID	2013	3	980,000.00
Australian Cancer Research Foundation South Australian Innovative Cancer Imaging And Therapeutics Facility	Infra-structure Support	Australian Cancer Research Foundation	CIC	2013	1	2,800,000.00
Is elevated N-cadherin expression a poor prognostic indicator in multiple myeloma patients?	Research Support	Cancer Australia and Leukaemia Foundation	CIA	2012	3	528,666.00
Does Modifying the bone marrow stromal micro-environment alter the disease course of multiple myeloma?	Research Support	Cancer Council of South Australia	CIA	2012	1	99,171.00
Efficacy of Targeting the mTOR and PI3 Kinase Pathways as a Treatment Modality for Myeloma	Industry Research Support	Novartis Pharma-ceuticals International	CIA	2011	1	65,000.00
Development of a Comprehensive Data Base for Myeloma and Related Disorders	Industry Support	Celgene Australia	CIB	2011	2	120,000.00
Seed Grant for the Establishment of a Multiple Myeloma and Related Disorders Database	Research Support	Cancer Council of South Australia	CIB	2011	1	35,000.00
Is mTOR a novel target for the treatment of osteoporosis?	Research Support	Research, Robinson Institute Collaborative Grant	CIA	2011	1	75,000.00
Abl Kinase Inhibition as a Novel Therapy for Myeloma-Associated Bone Loss	Research Support	Leukemia & Lymphoma Society - TRP	CIA	2009	3	750,000.00
Abl Kinase Inhibition as a Novel Therapy for Malignancy-Associated Bone Loss	Research Support	Cancer Council of South Australia	CIA	2009	1	93,000.00
Kodak chemiluminescence and gel imaging system (4000MM Pro Image Station).	Infra-structure Support	University of Adelaide/NH&MRC Equipment Grant	CIF	2008	1	55,000.00
Tyrosine Kinase Inhibition as a Potential Modality to Control Osteolytic Bone Disease: A New Role for Imatinib Mesylate and Second Generation Bcr-Abl Inhibitors	Industry Research Support	Novartis Pharma-ceuticals International	CIA	2007	3	470,000.00
Development of Strategies For The Therapeutic Use of Mesenchymal Precursor Cells For Cartilage Repair	Industry Support	Mesoblast Ltd	CIB	2006	2	320,692.00
Evaluation of the safety and efficacy of Allogeneic Mesenchymal Progenitor Cells (MPC) for the repair of critical size defects in an ovine tibial model	Industry Support	Mesoblast Ltd	CIB	2006	1	725,000.00
A Preclinical trial of the potential for cultured mesenchymal precursor cells to restore extracellular matrix and normal mechanical function to degenerate intervertebral discs	Industry/ Research Support	Mesoblast Ltd/ AusIndustry Grant	CIC	2006	2	794,850.00
BIR (Bortezomib Induction and Reinduction) Study	Clinical Trial and Research Support	Johnson & Johnson	CIB	2006	2	445,875.00
Can The Level of Stromal-Derived Factor-1 (SDF-1α) In Myeloma Patients Predict if They Will Develop Osteolytic Bone Disease?	Research Support	Cancer Council South Australia	CIA	2005	1	149,416.00
The Use of Aptamer-Based technologies to Identify Immuno-dominant Epitopes of Factor VIII Which are Responsible for the Development of Anti-Factor VIII Antibodies (Inhibitors)	Research Support	IMVS-Contributing Haematologist Committee Fund	CIA	2005	1	30,000.00
Can The Level of Stromal-Derived Factor-1 (SDF-1α) In Myeloma Patients Predict if They Will Develop Osteolytic Bone Disease?	Research Support	Royal Adelaide Hospital-IMVS Research Fund-Clinical Project Grants	CIA	2004	1	23,500.00
Mechanisms of Increased Microvessel Density (MVD) In Multiple Myeloma	Research Support	IMVS-Contributing Haematologist Committee Fund	CIA	2004	1	36,000.00
Can The Level of Stromal-Derived Factor-1 (SDF-1α) In Myeloma Patients Predict if They Will Develop Osteolytic Bone Disease?	Research Support	RAH/IMVS Clinical Research Grants	CIA	2004	1	18,500.00
Utilisation of human osteoblast and osteoclast co-culture models to study anti-resorptive and anabolic agents	Industry Support	Ely Lilly	CIC	2004	1	15,000.00
Research and Services Agreement	Industry/Research Support	Angioblast Ltd/ Mesoblast Ltd	CIB	2003	3	300,000.00
The Efficacy of Mesenchymal Precursor Cells to Repair Cardiac Defects	Industry Support	Angioblast Systems, Ltd	CIA	2003	2	100,000.00
Characterisation of RANKL and OPG production by human osteoblastic cells	Industry Support	Ely Lilly	CIB	2002	1	20,000.00
Tantalum and osteointegration	Industry Support	Zimmer	CIC	2002	1	45,000.00
Novel Interaction of the Epidermal Growth Factor-Like Protein DLK with the Growth Arrest-Specific Gene Product GAS-1: Implications for Adipocyte Differentiation	Research Support	IMVS/RAH Research Fund	CIB	2001	1	11,000.00
Characterisation of Novel Drug-Resistance Proteins in Human Leukaemic Cells	Industry Support	Medvet Pty Ltd	CIC	2000	1	110,000.00
The Identification and Characterization of Novel Regulators of Mesenchymal Stem Cell Differentiation and Lineage Commitment	Industry Support	Zymogenetics Inc., Seattle, Washington	CIA	1999	1	90,000.00

As a supervisor/mentor, I aim to provide an environment that:

Promotes strategic, independent, creative and critical scientific thinking;
Encourages a strong work ethic and a disciplined approach;
Supports the development of rigor in experimental design;
Encourages a sense of project ownership;
Promotes confidence and leadership;
Encourages effective interpersonal skills; and
Teaches effective written and verbal communication skills.

Teaching:

As a former full-time Medical Scientist in the Department of Haematology, SA Pathology/Institute of Medical and Veterinary Science and Level E Affiliate Titleholder in the School of Medicine, Faculty of Health Science, University of Adelaide, I provided leadership in teaching and supervision in my daily interactions with post-doctoral scientists, research assistants, undergraduate, graduate and post-graduate students. Furthermore, during this period, I provided numerous guest lectures (BBTech students, Uni SA; BHlthSci and MBBS, Uni Adelaide) and successfully mentored numerous honours, masters, PhD and medical students (as part of Department of Medicine’s 4th Year Research Program).

In addition to graduate and post-graduate teaching, since joining the University of Adelaide as Professor of Experimental Haematology, I present undergraduate lectures in courses offered by the Faculty of Health and Medical Science ([FHMS] Medicine, Physiology, Anatomy and Pathology and Dentistry), Faculty of Science ([FS] Masters program, stem cells) and the University of Sydney (tissue engineering). I provide Honours workshops relating to thesis writing, career opportunities and career development. I also host Physiology III (BHlthSci, FHMS) and Principals and Practice of Research III (BSc Advanced, FS) students in my laboratory for small group discovery and research training.

My abilities as a post-graduate educator and supervisor are manifest in the following outcomes:

Completions - 100% student completions
Awards for Excellence - Former students have received awards for excellence, including the University Medal (S Martin), Hugh Gilmore Prize (P Psaltis), Ross Wishart Memorial Award (P Psaltis), Nimmo Prize (P Psaltis), Hanson Institute Clinical Researcher of the Year Award for 2009 (D Harland/White), HSANZ Albert Baikie Memorial Medal (S Martin).
Post-Graduate Placements - Former students have been appointed to post-doctoral positions in prestigious institutions including Mt Sinai Hospital, NY (B Pan), Mayo Clinic, MN (P Psaltis), St Jude’s Hospital, TN (J Engler) or have gone onto significant positions in local institutions (D Harland/White, H Tsuji and C Oh).
Publications and Presentations - All past and present students have presented their findings at international and national scientific meetings, including oral presentations at major international conferences (American Society of Haematology, American Heart Association) and have published articles in highly cited and prized scientific journals (BLOOD, Cell Stem Cells, JACC), including featured articles in BLOOD, JBMR and JCEM.

Mentoring:

Post-Doctoral Scientist, Research Staff and Peer Training:

I currently supervise 8 post-doctoral scientists (Dr Duncan Hewett, Dr Stephen Fitter, Dr Sally Martin, Dr Kate Vandyke, Dr Jacqueline Noll, Dr Mel Cantley, Dr Bill Panagopoulos; Dr Krzysztof Mrozik), 3 Clinical Research Fellows (Dr Angie Yong, Dr Stanley Cheung, Dr Cindy Lee), 3 Research Assistants (Elyse Bell, Alanah Bradey, Rosa Harmer) and 2 technical officers (Mrs Vicki Wilczek and Mrs Lynda Saunders). Dr Kate Vandyke (Beat Cancer ECR Fellow), Dr Jacqueline Noll (Veronika Sacco Clinical Research Fellow), Dr Bill Panagopoulos (NHMRC ECR Fellow) and Dr Mel Cantley (NHMRC ECR Fellow) are self-funded research fellows, while the remainder of the staff are employed on peer reviewed, competitively awarded grants and industry funds. I advise post-doctoral staff in relation to their long-term career plans; aid with identifying independent research opportunities and encourage their supervision of students. This ensures that postdoctoral staff play an intrinsic role in the “education cycle” and possess the necessary skills for a successful independent research career.

Other Contributions to the Training/Mentoring Process:

In addition to graduate/post-graduate teaching, I also contribute to the formal education process by assessing honours and PhD theses. To date I have assessed in excess of 45 honour theses and 12 PhD theses from local, national and international Universities.

As an inaugural member of the Medical and Scientific Advisory Group (MSAG) of Myeloma Australia (http://www.myeloma.org.au) I contribute to the community’s and clinician’s awareness about myeloma. Furthermore, the MSAG provide guidance on both myeloma and supportive treatment strategies and have co-authored guidelines for the safe use of bisphosphonates (Dickinson M et al, Intern Med J. 2009. May;39(5):304-16; Lee et al., 1. Intern Med J, 47(8), 938-951.) and Multiple Myeloma Clinical Practice Guidelines (coordinated on behalf of the MFA-MSAG by Quach and Prince et al).

I also present lectures to a wide variety of organisations including Rotary Australia, The University of the Third Age, The Greek Women’s Philanthropic Society, The Australian Asian Women’s Association and Myeloma SA (a support group comprised of myeloma sufferers and their carers). I also host numerous guided, interactive tours of the Cancer Theme facilities at the SAHMRI (approximately 10 per year). These community engagement opportunities serve to raise the awareness of research activities being conducted at SAHMRI and the UA.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2023	Co-Supervisor	Investigating mechanisms of relapse in high-risk paediatric pre-B-cell acute lymphoblastic leukaemia	Doctor of Philosophy	Doctorate	Full Time	Mr Caleb Ben Lill
2022	Co-Supervisor	Lipidomic and metabolomic profiling of the bone marrow microenvironment to understand multiple myeloma disease development	Doctor of Philosophy	Doctorate	Part Time	Miss Mackenzie Rose Skinner
2022	Co-Supervisor	Genetic and biochemical characterisation of the SIK3 mutation, R393H: A causal mutation that helps define a new family of human monogenetic disorders	Doctor of Philosophy	Doctorate	Full Time	Eliana Gloria Stanziano
2022	Co-Supervisor	Modelling neurotoxicities following paediatric cancer treatments to improve cognitive outcomes and quality of survival	Doctor of Philosophy	Doctorate	Full Time	Miss Maya Rochelle Davies
2021	Co-Supervisor	Interventions and Novel Treatments for Obesity-associated Pathologies	Doctor of Philosophy	Doctorate	Full Time	Miss Alanah Loretta Bradey
2021	Principal Supervisor	Mechanisms of bortezomib-induced gut dysfunction and novel strategies to mitigate its impact in people with multiple myeloma.	Doctor of Philosophy	Doctorate	Full Time	Miss Jacqui Steele Scott
2021	Co-Supervisor	Targeting the bone marrow microenvironment: exploring Gremlin1’s role in myeloma-associated macrophages and developing IMiD-sensitive murine models of myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Emma Anna-Jane Cheney
2020	Co-Supervisor	Changes in the bone marrow microenvironment with progression to multiple myeloma	Doctor of Philosophy	Doctorate	Part Time	Miss Laura Joy Trainor
2020	Co-Supervisor	Identification of novel mechanisms that drive the dissemination of multiple myeloma tumour cells	Doctor of Philosophy	Doctorate	Full Time	Miss Hayley Bridget Parkinson

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2021 - 2025	Co-Supervisor	Elucidating the pro-tumorigenic role of myeloperoxidase in multiple myeloma and its potential as a novel therapeutic target	Doctor of Philosophy	Doctorate	Full Time	Mr Connor Maxwell Douglas Williams
2019 - 2023	Co-Supervisor	A Novel Antibiofilm Treatment for Surgical Site Infections	Doctor of Philosophy under a Jointly-awarded Degree Agreement with	Doctorate	Full Time	Mrs Laurine Dorothea Kaul
2019 - 2023	Principal Supervisor	The TAM receptor family in multiple myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Justine Rachel Clark
2019 - 2023	Principal Supervisor	The Role of Bone Marrow Mesenchymal Stromal Cell Senescence in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Natalya Plakhova
2017 - 2020	Co-Supervisor	CCR1 as a Therapeutic Target in Multiple Myeloma: Preventing Tumour Dissemination and Therapeutic Resistance	Doctor of Philosophy	Doctorate	Full Time	Miss Mara Natasha Zeissig
2017 - 2020	Co-Supervisor	Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells	Master of Philosophy	Master	Full Time	Dr Yu Chinn Joshua Chey
2017 - 2020	Principal Supervisor	The Role of Osteoblast-mTORC1 in the Regulation of Glucose Metabolism	Doctor of Philosophy	Doctorate	Full Time	Miss Pawanrat Tangseefa
2017 - 2021	Principal Supervisor	Macrophages, Myeloma, Mouse Models and Methodologies	Doctor of Philosophy	Doctorate	Full Time	Mrs Khatora Shanae Opperman
2015 - 2019	Co-Supervisor	Smart Materials for Cartilage and Bone Tissue Engineering	Doctor of Philosophy	Doctorate	Full Time	Mr Jiabin Zhang
2015 - 2019	Principal Supervisor	The Role of SAMSN1 in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Ms Natasha Friend
2015 - 2020	Principal Supervisor	The Role of Gremlin1 in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Mrs Kimberley Claire Clark
2014 - 2018	Principal Supervisor	A Genomic Approach Towards an Understanding of Clonal Evolution and Disease Progression in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Ankit Kumar Dutta
2013 - 2017	Principal Supervisor	The Role of TWIST1 in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Chee Man Cheong
2012 - 2018	Principal Supervisor	N-cadherin: Regulation, Role and Therapeutic Targeting in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Mr Krzysztof Mrozik
2011 - 2014	Co-Supervisor	Mesenchymal Stem Cells for the Treatment of Myocardial Infarction-Induced Ventricular Dysfunction	Doctor of Philosophy	Doctorate	Full Time	Dr James David Richardson
2011 - 2018	Co-Supervisor	Investigating the Role of HIF-1 and HIF-2 Transcription Factors in Multiple Myeloma	Doctor of Philosophy	Doctorate	Full Time	Miss Natalia Magdalena Martin
2010 - 2018	Principal Supervisor	The Role of mTORC1 in Mesenchymal Stem Cell Fate Determination, Osteoblast Differentiation and Skeletal Development	Doctor of Philosophy	Doctorate	Part Time	Ms Mary Patricia Matthews
2009 - 2013	Co-Supervisor	The Role of TWIST-1 in the Regulation of Mesenchymal Stem Cell Growth, Fracture Repair and Bone Loss	Doctor of Philosophy	Doctorate	Full Time	Mr Lachlan Cooper
2007 - 2011	Co-Supervisor	Cell Lineage, Cell Maturity and BCR-ABL: Factors Which Influence Imatinib Uptake in Chronic Myeloid Leukaemia	Doctor of Philosophy	Doctorate	Full Time	Ms Jane Engler
2007 - 2010	Principal Supervisor	The Effects of Tyrosine Kinase Inhibition on Bone Remodelling	Doctor of Philosophy	Doctorate	Full Time	Dr Kate Vandyke
2006 - 2010	Co-Supervisor	The Cardiovascular Reparative Properties of Bone Marrow Mesenchymal Precursor Cells	Doctor of Philosophy	Doctorate	Full Time	Prof Peter Psaltis
2005 - 2009	Principal Supervisor	Molecular and Cellular Mechanisms of Increased Angiogenesis in Multiple Myeloma: A Role for CXCL12	Doctor of Philosophy	Doctorate	Full Time	Dr Sally Martin
2005 - 2012	Co-Supervisor	Cellular and Molecular Mechanisms Involved in the Repair of the Injured Growth Plate in Young Rats	Doctor of Philosophy	Doctorate	Full Time	Ms Carmen Macsai
2004 - 2008	Co-Supervisor	Factors which Impact on the Response of CML Patients to ABL Kinase Inhibitor Therapy: A Study of Imatinib and Nilotinib	Doctor of Philosophy	Doctorate	Part Time	Prof Deborah Lee White
2002 - 2004	Principal Supervisor	Mechanisms of Skeletal Disease Mediated by Haematological Malignancies	Doctor of Philosophy	Doctorate	Full Time	Miss Beiqing Pan
2001 - 2002	Principal Supervisor	CLINICAL MEDICINE	Master of Medical Science	Master	Full Time	Miss Beiqing Pan

Board Memberships

Date	Role	Board name	Institution name	Country
2020 - 2020	Member	Ministerial Advisory Board - Health and Medical Industries	Department of Industry and Skills, Government of South Australia	Australia
2020 - ongoing	Member	Ministerial Implementation Board – Health and Medical Industries	Department of Industry and Skills, Government of South Australia	Australia
2019 - ongoing	Member	Board	Health Translation SA (HTSA)	Australia
2019 - ongoing	Member	Board	Adelaide BioMed City	Australia
2015 - 2019	Member	Board of Directors	Colgate Australian Clinical Dental Research Centre, University of Adelaide	Australia
2014 - ongoing	Member	Advisory Board	Robinson Research Institute (RRI), University of Adelaide	Australia

Committee Memberships

Date	Role	Committee	Institution	Country
2019 - ongoing	Chair	Research Advisory Committee	Adelaide BioMed City	Australia
2016 - ongoing	Member	ARCPOH Expert Advisory Committee	University of Adelaide	Australia
2014 - 2018	Member	NHMRC Assigners Academy	National Health and Medical Research Council	Australia
2014 - 2015	Chair	Research Committee, School of Medical Science	University of Adelaide	Australia
2012 - ongoing	Member	Bioscience Pillar Committee	South Australian Health and Medical Research Institute (SAHMRI)	Australia
2012 - 2012	Member	Robinson Institute Transition Management Committee	University of Adelaide	Australia
2012 - 2012	Member	Leukaemia Foundation National Research Program Assessment Panel	Leukaemia Foundation	Australia
2011 - 2011	Member	Reshaping the Robinson Task Force, Robinson Institute	University of Adelaide	Australia
2010 - 2015	Member	Scientific Advisory Committee	Bone Health Foundation	Australia
2010 - 2013	Member	Fellowships and Scholarships Committee	Leukaemia Foundation of Australia	Australia
2009 - 2012	Member	Medical Assessment Classification Committee	SA Pathology	Australia
2007 - 2012	Co-Chair	Institutional Biosafety Committee	SA Pathology/Institute of Medical and Veterinary Science	Australia

Memberships

Date	Role	Membership	Country
2019 - ongoing	Member	Beat Cancer Project Executive Management Group	Australia
2012 - ongoing	Member	Cell Reprogramming Australia (CRA)	Australia
2010 - ongoing	Member	Centre for Personalised Cancer Medicine, University of Adelaide	Australia
2010 - ongoing	Member	Centre for Stem Cell Research, University of Adelaide	Australia
2010 - ongoing	Member	Centre for Cancer Biology, SA Pathology	Australia

Offices Held

Date	Office Name	Institution	Country
2020 - ongoing	Non-executive director	AusHealth Pty Ltd	Australia
2012 - 2012	Cancer Biology and Oncology GRP	National Health and Medical Research Council	Australia
2010 - 2010	Oncology GRP	National Health and Medical Research Council	Australia
2006 - ongoing	Cell Biology GRP	National Health and Medical Research Council	Australia

Review, Assessment, Editorial and Advice

Date	Title	Type	Institution	Country
2018 - 2019	NHMRC Ideas Grant Review Panel	Grant Assessment	National Health and Medical Research Council	Australia
2013 - 2017	Subject Matter Expert and Assessor, Science and Industry Endowment Fund (SIEF)	Grant Assessment	CSIRO	Australia
2010 - 2010	Subject Matter Expert, Facilities and Laboratory Operations	Advice	South Australian Health and Medical Research Institute	Australia
2006 - ongoing	Medical and Scientific Advisory Group	Advice	Myeloma Foundation of Australia	Australia

Position: Executive Dean
Phone: 83135193
Email: andrew.zannettino@adelaide.edu.au
Campus: North Terrace
Building: Helen Mayo North, floor 3
Org Unit: Faculty of Health and Medical Sciences

Professor Andrew Zannettino

Research Interests

Myeloma and Bone Cancer Research

The MRL has made, and continues to make significant contributions to the field through ongoing projects in:

Therapeutic Use of Mesenchymal Progenitor Cells

Research Collaborations

Research Output

Presentations

Additional Evidence of Research Leadership

Clinical Outcomes of Research

Patents

Awards and Achievements

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Datasets

Research Funding

As a supervisor/mentor, I aim to provide an environment that:

Teaching:

Mentoring:

Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

Board Memberships

Committee Memberships

Memberships

Offices Held

Review, Assessment, Editorial and Advice

Connect With Me

External Profiles