Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Krzysztof M. Mrozik completed his PhD studies in 2018 at the The University of Adelaide, Australia. His PhD research focused on identifying novel therapeutic targets in the haematological cancer multiple myeloma (MM). These studies identified that targeting of a cell adhesion molecule, N-cadherin, as a mono-therapy, or in combination with the anti-MM agent bortezomib, could potentially delay or prevent MM disease relapse. During his PhD candidature, Dr Mrozik received numerous honours including the Lawrence Catley Memorial Award for Best Abstract at the 2016 National Myeloma Workshop, and he was a 2018 Ross Wishart Memorial Award finalist at the ASMR SA Scientific Meeting. Dr Mrozik was also awarded a Dean’s Commendation for Doctoral Thesis Excellence.
In July 2018, Dr Mrozik commenced a postdoctoral position in the Myeloma Research Laboratory with Prof. Andrew C.W. Zannettino and Dr Kate Vandyke. To date, Dr Mrozik has co-authored 23 publications, including 8 as first author.
Debilitating drug side effects and disease relapse currently represent major challenges in the therapeutic management of individuals with MM and many other cancers. Dr Mrozik is developing novel strategies, including the use of state-of-the-art nanoparticle systems and vascular-modulating agents, to selectively increase drug delivery to sites of tumour and reduce drug exposure to healthy tissues. He is also investigating strategies to eliminate dormant, therapy-resistant cancer cells in order to delay or prevent MM disease relapse. As a passionate and highly motivated medical researcher, Dr Mrozik’s goal is to palpably improve the quality-of-life and survivorship of individuals with MM and other cancers.
Dr Mrozik's projects in the Myeloma Research Laboratory, based at SAHMRI:
Title: Novel approaches for increasing efficacy and decreasing side-effects in the treatment of MM
Description: A major cause of the dose-limiting toxicities associated with many anti-cancer agents is their systemic distribution following administration. Here, we are investigating novel approaches, including state-of-the-art nanoparticles systems and vascular-modulating agents, to selectively increase the delivery of anti-MM drugs with dose-limiting toxicities to MM tumour sites, in order to reduce their debilitating side-effects.
Title: MM plasma cell dormancy - 'eradicating the sleeping giant'
Description: The activation of drug-resistant dormant MM cells is thought to play a key role in the inevitable relapse of MM patients following therapy. Here, we are using next-generation single-cell RNA sequencing to identify, and therapeutically target, a population of dormant cancer cells in MM patients, and to identify sub-populations of stromal cells within the bone marrow microenvironment that control MM cell dormancy.
Title: The role of stromal cell senescence in MM disease progression
Description: Ageing represents a significant risk factor for progression from asymptomatic MGUS to active MM, suggesting that age-related cellular changes may promote MM cell proliferation and progression to MM. Here, we are investigating whether stromal cell senescence leads to increased proliferation of clonal MM cells, resulting in the outgrowth of malignant clones and progression to active MM.
Date Position Institution name 2018 Postdoctoral Researcher The University of Adelaide 2004 - 2012 Senior Research Associate The University of Adelaide 2001 - 2004 Research Associate The University of Adelaide 1999 - 2001 Research Associate Women's and Children's Hospital, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Scholarship Faculty of Health Sciences Divisional PhD Scholarship University of Adelaide Australia —
Language Competency Polish Can read, write, speak and understand spoken
Date Institution name Country Title 2012 - 2018 The University of Adelaide Australia PhD 1998 - 1998 The University of Adelaide Australia Honours Degree
Year Citation 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. (2017). HIF-2 alpha Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. 2014 Vandyke, K., Mrozik, K. M., Cheong, C. M., Chow, A. W., Kok, C. H., Blaschuk, O., . . . Zannettino, A. C. (2014). Identification of an Epithelial-to-Mesenchymal Transition (EMT)-like Programme in t(4;14)-Positive Multiple Myeloma Reveals Novel Targets for Therapeutic Intervention. In BLOOD Vol. 124 (pp. 3 pages). San Francisco, CA: AMER SOC HEMATOLOGY.
Title: Beat Cancer project travel grant 2015: Attendance at the 15th International Myeloma Workshop. Funding scheme: ORG112382: SAHMRI Beat Cancer Project Travel Grant (2015). Mrozik K; Zannettino A
Investigation of periodontal ligament stem cell self-renewal, survival and tissue regeneration in vivo. Funding scheme: 900141: ADRF - Grant (2010). Mrozik K; Gronthos S; Bartold P; Zilm P
Title: Proteomic assessment of mesenchymal stem cells within ovine periodontal ligament and dental pulp. Funding scheme: 900141: ADRF - Grant (2007). Mrozik K; Gronthos S; Bartold P; Zilm P
Title: Proteomic assessment of mesenchymal stem cells within ovine periodontal ligament and dental pulp. Funding scheme: 900141: ADRF - Grant (2006). Mrozik K; Bartold P; Gronthos S; Zilm P
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor The Yin and Yang of Myeloma Development: The Role of the Bone Marrow Microenvironment in Plasma Cell Dormancy and Activation Master of Philosophy (Medical Science) Master Full Time Miss Natalya Plakhova
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