Externally Funded Research Fellow (A)
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
After completing his PhD studies in July 2018 at The University of Adelaide, Dr Krzysztof M. Mrozik commenced a postdoctoral position in the Myeloma Research Laboratory (MRL) co-headed by Prof. Andrew C.W. Zannettino and Dr Kate Vandyke. To date, Dr Mrozik has co-authored 29 publications (9 as first author; 70% in Q1 journals [Scimago]; >1670 citations, h-index = 21 [Google Scholar], Field-Weighted Citation Impact [FWCI] = 2.0 [Scopus]), including 11 in the myeloma field (six since January 2020).
Drug therapy-related side effects and disease relapse represent major challenges in the management of people with the debilitating bone marrow cancer, multiple myeloma. These issues compromise the physical and emotional well-being of individuals with myeloma, by reducing their quality of life and overall survival. Improving drug access to sites of myeloma tumour represents a promising strategy to improve depth of tumour response to therapy and to reduce off-target side effects.
Dr Mrozik is developing novel drug delivery platforms, including the use of tumour vasculature-modulating agents and state-of-the-art nanoparticle systems, to selectively increase drug delivery to sites of myeloma tumour in bones. His research also focuses on understanding the pathobiology of drug-induced side effects in myeloma, particularly in relation to the standard-of-care therapy, bortezomib.
As a passionate and highly motivated researcher, Dr Mrozik’s goal is to palpably improve the quality-of-life and survivorship of individuals with MM and other cancers. In 2020, he was awarded a Cancer Council SA Beat Cancer Project Early Career Cancer Research Fellowship to support his research program.
Dr Mrozik's projects in the Myeloma Research Laboratory, based at SAHMRI:
Title: Novel approaches for increasing efficacy and decreasing side-effects in the treatment of MM
Description: A major cause of the dose-limiting toxicities associated with many anti-cancer agents is their systemic distribution following administration. Here, we are investigating novel approaches, including state-of-the-art nanoparticles systems and vascular-modulating agents, to selectively increase the delivery of anti-MM drugs with dose-limiting toxicities to MM tumour sites, in order to reduce their debilitating side-effects.
Title: The role of stromal cell senescence in MM disease progression
Description: Ageing represents a significant risk factor for progression from asymptomatic MGUS to active MM, suggesting that age-related cellular changes may promote MM cell proliferation and progression to MM. Here, we are investigating whether stromal cell senescence leads to increased proliferation of clonal MM cells, resulting in the outgrowth of malignant clones and progression to active MM.
Title: MM plasma cell dormancy - 'eradicating the sleeping giant'
Description: The activation of drug-resistant dormant MM cells is thought to play a key role in the inevitable relapse of MM patients following therapy. Here, we are using next-generation single-cell RNA sequencing to identify, and therapeutically target, a population of dormant cancer cells in MM patients, and to identify sub-populations of stromal cells within the bone marrow microenvironment that control MM cell dormancy.
Date Position Institution name 2020 - ongoing Beat Cancer Project Early Career Cancer Research Fellow University of Adelaide 2018 - 2020 Postdoctoral Researcher The University of Adelaide 2004 - 2012 Senior Research Associate The University of Adelaide 2001 - 2004 Research Associate The University of Adelaide 1999 - 2001 Research Associate Women's and Children's Hospital, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Scholarship Faculty of Health Sciences Divisional PhD Scholarship University of Adelaide Australia
Language Competency Polish Can read, write, speak and understand spoken
Date Institution name Country Title 2012 - 2018 The University of Adelaide Australia PhD 1998 - 1998 The University of Adelaide Australia Honours Degree
Year Citation 2017 Mrozik, K., Gronthos, S., Shi, S., & Bartold, P. M. (2017). A method to isolate, purify, and characterize human periodontal ligament stem cells. In Methods in Molecular Biology (Vol. 1537, pp. 413-427). Springer New York.
DOI Scopus22 Europe PMC9
2012 Mrozik, K., Xiong, J., Zilm, P., Gronthos, S., & Bartold, P. (2012). Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. In M. Hayat (Ed.), Stem cells and cancer stem cells: Therapeutic applications in disease and injury. Volume 4 (pp. 267-284). Springer.
2012 Mrozik, K., Xiong, J., Zilm, P., Gronthos, S., & Bartold, P. (2012). Proteomic Characterization of Mesenchymal Stem Cell-Like Populations Derived from Various Tissue Types. In M. Hayat (Ed.), Stem cells and cancer stem cells: Therapeutic applications in disease and injury. Volume 3 (pp. 75-94). New York: Springer.
2010 Mrozik, K., Gronthos, S., Shi, S., & Bartold, P. (2010). A method to isolate, purify, and characterize human periodontal ligament stem cells. In G. Seymour, M. Cullinan, & N. Heng (Eds.), Oral Biology: Molecular Techniques and Applications (Vol. 666, 1 ed., pp. 269-284). USA: Humana Press.
DOI Scopus40 Europe PMC29
Year Citation 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. W. (2017). HIF-2 alpha Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. 2014 Vandyke, K., Mrozik, K. M., Cheong, C. M., Chow, A. W. S., Kok, C. H., Blaschuk, O., . . . Zannettino, A. C. W. (2014). Identification of an Epithelial-to-Mesenchymal Transition (EMT)-like Programme in t(4;14)-Positive Multiple Myeloma Reveals Novel Targets for Therapeutic Intervention. In BLOOD Vol. 124 (pp. 3 pages). San Francisco, CA: AMER SOC HEMATOLOGY.
Year Citation 2019 Zeissig, M. N., Hewett, D. R., Mrozik, K. M., Panagopoulos, V., Engelhardt, M., To, L. B., . . . Vandyke, K. (2019). Therapeutic Targeting of CCR1 to Prevent Dissemination of Multiple Myeloma Plasma Cells. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
2019 Cancer Council SA Beat Cancer Project Early Career Cancer Research Fellowship 2020-2023 ($480,000)
2019 Tour de Cure Annual Grant Program ($50,000)
Title: Cancer Council SA Beat Cancer Project travel grant 2015: Attendance at the 15th International Myeloma Workshop. Funding scheme: ORG112382: SAHMRI Beat Cancer Project Travel Grant (2015). Mrozik K; Zannettino A
Title: Investigation of periodontal ligament stem cell self-renewal, survival and tissue regeneration in vivo. Funding scheme: 900141: ADRF - Grant (2010). Mrozik K; Gronthos S; Bartold P; Zilm P
Title: Proteomic assessment of mesenchymal stem cells within ovine periodontal ligament and dental pulp. Funding scheme: 900141: ADRF - Grant (2007). Mrozik K; Gronthos S; Bartold P; Zilm P
Title: Proteomic assessment of mesenchymal stem cells within ovine periodontal ligament and dental pulp. Funding scheme: 900141: ADRF - Grant (2006). Mrozik K; Bartold P; Gronthos S; Zilm P
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Co-Supervisor Mechanisms of bortezomib-induced gut dysfunction and novel strategies to mitigate its impact in people with multiple myeloma. Doctor of Philosophy Doctorate Full Time Miss Jacqui Steele Scott 2020 Co-Supervisor Development and assessment of novel drug delivery strategies to improve the treatment of multiple myeloma Doctor of Philosophy Doctorate Part Time Ms Sadia Munir 2019 Co-Supervisor The Yin and Yang of Myeloma Development: The Role of the Bone Marrow Microenvironment in Plasma Cell Dormancy and Activation Doctor of Philosophy Doctorate Full Time Miss Natalya Plakhova
Date Event Name Event Type Institution Country 2021 - ongoing 15th Annual Florey Postgraduate Research Conference - Poster Assessor Conference University of Adelaide Australia 2018 - ongoing SAHMRI Research Showcase - 3-Minute Thesis Assessor Conference SAHMRI 2018 - ongoing Annual Florey Postgraduate Research Conference - Poster Assessor Conference University of Adelaide
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