Kate Vandyke

Dr Kate Vandyke

Postdoctoral Research Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


I am currently a Cancer Council SA Beat Cancer Early Career Research Fellow in the Myeloma Research Laboratory, Adelaide Medical School, University of Adelaide, based at the South Australian Health and Medical Research Institute (SAHMRI), Cancer Theme.

My PhD research centred on characterising the off-target effects of tyrosine kinase inhibitors on bone metabolism and skeletal growth in chronic myeloid leukaemia. My current research interests involve elucidating the molecular and cellular mechanisms responsible for the disease progression in the bone marrow cancer multiple myeloma.

My current research interests involve elucidating the molecular and cellular mechanisms responsible for the disease progression in the bone marrow cancer multiple myeloma. Myeloma is the second most common blood cancer, responsible for approximately 80,000 deaths per year, world-wide. While significant advances in myeloma treatment over the past decade have greatly improved survival rates for multiple myeloma, almost all patients eventually relapse and succumb to their disease. My studies are primarily aimed at identifying those patients that do very poorly, surviving less than 2 years, and identifying tailored treatments for this group of patients.

The progression and relapse of myeloma tumours is critically dependent on the ability of the myeloma tumour cells to disseminate to sites throughout the skeleton. In particular, previous studies have identified that those patients with highly disseminated disease at diagnosis do particularly poorly, leading to rapid disease progression and disease relapse. One of my primary research interests focuses on identifying the intrinsic and extrinsic factors involved in the recirculation and dissemination process in myeloma with the aim of developing therapeutic strategies that will prevent disease progression and overt relapse in these patients.

https://health.adelaide.edu.au/florey120anniversary/our-current-health-leaders/decoding-myeloma-cancer

Current projects include:

• Identification of novel prognostic factors that identify patients at a high risk of disease progression in myeloma
• Investigation of the mechanisms controlling the dissemination of myeloma plasma cells, including hypoxia, chemokine receptors and N-cadherin
• Identification of novel therapeutic targets for the treatment of high-risk multiple myeloma
• Characterisation of the off-target effects of a class of leukaemia drugs, termed tyrosine kinase inhibitors, on bone metabolism and skeletal growth

 

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  • Appointments

    Date Position Institution name
    2018 Beat Cancer Early Career Research Fellow University of Adelaide, Adelaide
    2017 - 2018 Post-doctoral Research Scientist University of Adelaide, Adelaide
    2013 - 2016 Mary Overton Early Career Research Fellow SA Pathology
    2012 - 2018 Affiliate Lecturer University of Adelaide
    2012 - 2013 Multiple Myeloma Research Foundation Research Fellow SA Pathology
    2010 - 2012 Post-doctoral Research Scientist SA Pathology
    2007 - 2010 Technical assistant (part time) SA Pathology
    2005 - 2006 Research Assistant Prince of Wales Hospital
  • Education

    Date Institution name Country Title
    2007 - 2010 University of Adelaide Australia PhD
    2000 - 2004 University of New South Wales Australia BMedSci (Hons)
  • Research Interests

Date Role Grant Funding Body Amount
Grants
2019 - 2020 CIA Cancer Australia Priority-driven Young Investigator Grant Cancer Australia/Cure Cancer Australia/Leukaemia Foundation AUD$198,596
2017-2018 CIA Cancer Australia Priority-driven Young Investigator Grant Cure Cancer Australia AUD$199,454
2016 CIA Project Grant Royal Adelaide Hospital Contributing Haematologists' Committee AUD$25,000
2016 CIE Project Grant Royal Adelaide Hospital Research Fund AUD$50,000
Date Title Funding Body Amount
Fellowships
2018-2021 Beat Cancer Early Career Cancer Research Fellowship Cancer Council SA AUD$240,000
2013-2015 Mary Overton Early Career Fellowship Royal Adelaide Hospital AUD$252,000
2013-2015 Veronika Sacco Early Career Fellowship Florey Medical Research Foundation AUD$222,003
2011 MMRF Research Fellow Award Multiple Myeloma Research Foundation (USA) AUD$74,146
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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Investigating the Role of Resident Bone Macrophages in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mrs Khatora Shanae Opperman
    2019 Co-Supervisor The Yin and Yang of Myeloma Development: The Role of the Bone Marrow Microenvironment in Plasma Cell Dormancy and Activation Doctor of Philosophy Doctorate Full Time Miss Natalya Plakhova
    2017 Co-Supervisor Investigation of the competing effects of the CXCL12/CXCR4 and CCL3/CCR1 chemokine axes in the dissemination and migration of multiple myeloma plasma cells Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2013 - 2017 Co-Supervisor The Role of TWIST1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Chee Man Cheong
    2012 - 2018 Co-Supervisor N-cadherin: Regulation, Role and Therapeutic Targeting in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mr Krzysztof Mrozik
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  • Committee Memberships

    Date Role Committee Institution Country
    2015 - ongoing Member Women's and Children's Hospital Foundation Research Grants Committee
    2014 - ongoing Member Australian Society for Medical Research SA Committee
  • Memberships

    Date Role Membership Country
    2015 - ongoing Haematology Society of Australia and New Zealand
    2014 - ongoing Member Australian Society for Medical Research
  • Position: Postdoctoral Research Fellow
  • Phone: 81284694
  • Email: kate.vandyke@adelaide.edu.au
  • Campus: North Terrace West
  • Building: SAHMRI - South, floor 5
  • Org Unit: Medical Sciences

Connect With Me
External Profiles