Kate Vandyke

Dr Kate Vandyke

Research Fellow (B) (with PhD)

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


I am currently a Cancer Council SA Beat Cancer Early Career Research Fellow and co-lead of the Myeloma Research Laboratory, Faculty of Health and Medical Sciences, University of Adelaide, based at the South Australian Health and Medical Research Institute (SAHMRI), Precision Medicine Theme.

My research interests involve elucidating the molecular and cellular mechanisms responsible for the disease progression in the bone marrow cancer multiple myeloma. Myeloma is the second most common blood cancer, responsible for over 100,000 deaths per year, world-wide. While significant advances in myeloma treatment over the past decade have greatly improved survival rates for multiple myeloma, almost all patients eventually relapse and succumb to their disease. My studies are primarily aimed at identifying those patients that do very poorly, surviving less than 2 years, and identifying tailored treatments for this group of patients.https://aurora.adelaide.edu.au/userprofile.html?uid=3778&em=true#

My current research interests involve elucidating the molecular and cellular mechanisms responsible for the disease progression in the bone marrow cancer multiple myeloma. Myeloma is the second most common blood cancer, responsible for over 100,000 deaths per year, world-wide. While significant advances in myeloma treatment over the past decade have greatly improved survival rates for multiple myeloma, almost all patients eventually relapse and succumb to their disease. My studies are primarily aimed at identifying those patients that do very poorly, surviving less than 2 years, and identifying tailored treatments for this group of patients.

https://health.adelaide.edu.au/florey120anniversary/our-current-health-leaders/decoding-myeloma-cancer

Current projects include:
  • Defining major cellular and molecular mechanisms that drive tumour dissemination in multiple myeloma
  • Identifying how changes to the myeloma bone marrow microenvironment drive disease progression for MGUS and smouldering myeloma to multiple myeloma
  • Identification of novel serum biomarkers that enable the identification of high-risk MGUS, smouldering myeloma and multiple myeloma patients
  • Using novel drug delivery strategies to increase tumour-specific drug uptake and decrease off-target side-effects in multiple myeloma
  • Identification of novel therapeutic targets for the treatment of high-risk multiple myeloma
  • Appointments

    Date Position Institution name
    2020 - ongoing Senior research fellow South Australian Health and Medical Research Institute
    2018 - ongoing Beat Cancer Early Career Research Fellow University of Adelaide, Adelaide
    2017 - 2018 Post-doctoral Research Scientist University of Adelaide, Adelaide
    2013 - 2016 Mary Overton Early Career Research Fellow SA Pathology
    2012 - 2018 Affiliate Lecturer University of Adelaide
    2012 - 2013 Multiple Myeloma Research Foundation Research Fellow SA Pathology
    2010 - 2012 Post-doctoral Research Scientist SA Pathology
    2007 - 2010 Technical assistant (part time) SA Pathology
    2005 - 2006 Research Assistant Prince of Wales Hospital
  • Education

    Date Institution name Country Title
    2007 - 2010 University of Adelaide Australia PhD
    2000 - 2004 University of New South Wales Australia BMedSci (Hons)
  • Research Interests

Date Role Grant Funding Body Amount
Grants
2021-2023 CIA Cancer Australia Priority-driven Young Investigator Grant Cancer Australia/Cure Cancer Australia/Snowdome Foundation AUD$198,813
2019-2022 CoI Strategic Ecosystem Research Partnerships Leukaemia Foundation AUD$596,198
2019 - 2021 CIA Cancer Australia Priority-driven Young Investigator Grant Cancer Australia/Cure Cancer Australia/Leukaemia Foundation AUD$198,596
2017-2018 CIA Cancer Australia Priority-driven Young Investigator Grant Cure Cancer Australia AUD$199,454
2016 CIA Project Grant Royal Adelaide Hospital Contributing Haematologists' Committee AUD$25,000
2016 CIE Project Grant Royal Adelaide Hospital Research Fund AUD$50,000
Date Title Funding Body Amount
Fellowships
2018-2021 Beat Cancer Early Career Cancer Research Fellowship Cancer Council SA AUD$240,000
2013-2015 Mary Overton Early Career Fellowship Royal Adelaide Hospital AUD$252,000
2013-2015 Veronika Sacco Early Career Fellowship Florey Medical Research Foundation AUD$222,003
2011 MMRF Research Fellow Award Multiple Myeloma Research Foundation (USA) AUD$74,146
  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2022 Co-Supervisor Lipidomic and metabolomic profiling of the bone marrow microenvironment to understand multiple myeloma disease development Doctor of Philosophy Doctorate Full Time Miss Mackenzie Rose Skinner
    2020 Co-Supervisor Identification of novel mechanisms that drive the dissemination of multiple myeloma tumour cells Doctor of Philosophy Doctorate Full Time Miss Hayley Bridget Parkinson
    2020 Co-Supervisor Changes in the bone marrow microenvironment with progression to multiple myeloma Doctor of Philosophy Doctorate Full Time Miss Laura Joy Trainor
    2020 Principal Supervisor Development and assessment of novel drug delivery strategies to improve the treatment of multiple myeloma Doctor of Philosophy Doctorate Full Time Ms Sadia Munir
    2019 Co-Supervisor The Yin and Yang of Myeloma Development: The Role of the Bone Marrow Microenvironment in Plasma Cell Dormancy and Activation Doctor of Philosophy Doctorate Full Time Miss Natalya Plakhova
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2021 Co-Supervisor Macrophages, Myeloma, Mouse Models and Methodologies Doctor of Philosophy Doctorate Full Time Mrs Khatora Shanae Opperman
    2017 - 2020 Principal Supervisor CCR1 as a Therapeutic Target in Multiple Myeloma: Preventing Tumour Dissemination and Therapeutic Resistance Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig
    2013 - 2017 Co-Supervisor The Role of TWIST1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Chee Man Cheong
    2012 - 2018 Co-Supervisor N-cadherin: Regulation, Role and Therapeutic Targeting in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mr Krzysztof Mrozik
  • Committee Memberships

    Date Role Committee Institution Country
    2015 - ongoing Member Women's and Children's Hospital Foundation Research Grants Committee
    2014 - ongoing Member Australian Society for Medical Research SA Committee
  • Memberships

    Date Role Membership Country
    2021 - ongoing Member International Myeloma Society United States
    2019 - ongoing Member Australasian Leukaemia and Lymphoma Group Australia
    2015 - ongoing Haematology Society of Australia and New Zealand
    2014 - ongoing Member Australian Society for Medical Research
  • Position: Research Fellow (B) (with PhD)
  • Phone: 81284694
  • Email: kate.vandyke@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI - South, floor 5
  • Org Unit: Medical Sciences

Connect With Me
External Profiles