
Dr Sally Martin
Lecturer
School of Biomedicine
Faculty of Health and Medical Sciences
Dr Martin is currently a post-doctoral researcher in the Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, based at the SAHMRI, Cancer Theme.
Dr Martin's PhD research, completed in 2009, centred on bone marrow angiogenesis and osteolytic bone disease in the haematological malignancy, multiple myeloma. Since completing her PhD studies, Dr Martin has been examining the role of the PI3K and mTOR signalling pathways in bone development, looking at ways to exploit these pathways to stimulate bone formation in disease settings such as osteoporosis and tumour-associated bone loss.
Dr Martin is an affiliate lecturer in the School of Medical Sciences and the School of Medicine, University of Adelaide.
Dr Martin's current research projects are focussed on (1) the role of the mTOR signalling pathways in mesenchymal stem cell biology, (2) the role of the mTOR signalling pathways in regulating skeletal biology and bone remodelling, and (3) the role of skeletal mTORC1 signalling in B-cell development and glucose homeostasis.
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Appointments
Date Position Institution name 2015 - ongoing Post-doctoral Researcher University of Adelaide, Adelaide 2013 - ongoing Affiliate Lecturer University of Adelaide 2012 - ongoing Affiliate Lecturer University of Adelaide 2009 - 2015 Post-doctoral Researcher SA Pathology 2003 - 2008 Technical Assistant (part-time) Institute of Medical and Veterinary Science (IMVS) -
Education
Date Institution name Country Title 2005 - 2008 University of Adelaide, Adelaide Australia PhD 2000 - 2004 University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechnology (Hons)
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Journals
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Book Chapters
Year Citation 2008 Zannettino, A., Martin, S. K., Gronthos, S., To, L., & Peet, D. (2008). The role of CXCL12 in multiple myeloma. In F. columbus (Ed.), Cancer Research Progress. Nova Science Publishers. -
Conference Papers
Year Citation 2018 Tangseefa, P., Martin, S. K., Wilczek, V., Baldock, P., Proud, C. G., Fitter, S., & Zannettino, A. C. W. (2018). Metabolic and reproductive abnormalities in mice with impaired skeletal-mTORC1 function mirror a dietary restriction phenotype. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 19). Perth, AUSTRALIA: WILEY. 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. W. (2017). HIF-2α Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. 2013 Forristal, C. E., Helwani, F., Martin, S., Nowlan, B., Winkler, I. G., Zannettino, A., & Levesque, J. -P. (2013). Hypoxia Inducible Factor (HIF)-2α Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow. In BLOOD Vol. 122 (pp. 2 pages). New Orleans, LA: AMER SOC HEMATOLOGY.
WoS12008 Martin, S. K., Diamond, P., To, L. B., Pect, D., Gronthos, S., & Zannettino, A. W. W. (2008). CXCL12 Expression Is Regulated by HIF-2a in Multiple Myeloma Plasma Cells. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 23 (pp. S262). Montreal, CANADA: AMER SOC BONE & MINERAL RES. 2008 Diamond, P., Labrinidis, A., Martin, S. K., Farrugia, A., Gronthos, S., To, L. B., . . . Zannettino, A. (2008). CXCL12 stimulates osteoclastic bone resorption in a novel mouse model of human multiple myeloma. In Journal of Bone and Mineral Research Vol. 23 (pp. S262). Montreal: American Society for Bone and Mineral Research. 2007 Martin, S. K., Dewar, A., Farrugia, A., Horvath, N., Gronthos, S., To, L. B., & Zannettino, A. (2007). Tumour angiogenesis is associated with plasma levels of stromal-derived factor-1a in patients with multiple myeloma. In Haematologica Vol. 92 (pp. 125-126). Kos, Greece: Ferrata Storti Foundation. 2007 Martin, S. K., Dewar, A. L., Farrugia, A. N., Horvath, N., Gronthos, S., To, L. B., & Zannettino, A. C. W. (2007). Tumour angiogenesis correlates with plasma levels of CXCL12 in patients with multiple myeloma. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 92 (pp. 125-126). Kos Isl, GREECE: FERRATA STORTI FOUNDATION. 2007 Diamond, P., Labrinidis, A., Martin, S. K., Farrugia, A. N., Gronthos, S., To, L. B., . . . Zannettino, A. C. W. (2007). CXCL12 stimulates osteoclastic bone resorption in a novel mouse model of human multiple myeloma. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 92 (pp. 130). Kos Isl, GREECE: FERRATA STORTI FOUNDATION. -
Conference Items
Year Citation 2013 Forristal, C., Helwani, F., Nowlan, B., Martin, S., Zannetino, A., & Levesque, J. -P. (2013). HYPOXIA INDUCIBLE FACTOR (HIF)-2 alpha ENHANCES PROLIFERATION OF MALIGNANT HAEMATOPOIETIC CELLS IN THE HYPOXIC MALIGNANT BONE MARROW. Poster session presented at the meeting of EXPERIMENTAL HEMATOLOGY. Vienna, AUSTRIA: ELSEVIER SCIENCE INC.
Mary Overton Early Career Research Fellowship (2012 - 2015), The role of the raptor and rictor signalling pathways in skeletal biology, AUD$252,000
Centre for Stem Cell Research Project Grant 2012, The role of raptor and rictor in MSC differentiation, AUD$75,000
Novartis Pharmaceuticals Project Grant 2011, Can the dual PI3K/mTOR inhibitor NVP-BEZ235 be used to stimulate bone formation in multiple myeloma? AUD$75,000.
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2020 Co-Supervisor The Role of Osteoblast-mTORC1 in the Regulation of Glucose Metabolism Doctor of Philosophy Doctorate Full Time Miss Pawanrat Tangseefa 2013 - 2018 Co-Supervisor The Role of mTORC1 in Mesenchymal Stem Cell Fate Determination, Osteoblast Differentiation and Skeletal Development Doctor of Philosophy Doctorate Part Time Ms Mary Patricia Matthews
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