Peter Hoffmann

Professor Peter Hoffmann

Prof Bio Sci - Dir Adelaide Proteomics Ct

School of Biological Sciences

Faculty of Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Prof Peter Hoffmann is Deputy Director of the Institute for Photonics and Advanced Sensing (IPAS), Director of the Adelaide Proteomics Centre and Director of the National NCRIS facility for Tissue Imaging Mass Spectrometry. Peter is a HUPO Council Member, the Vice President of the Australasian Proteomics Society, Conference Chair for the National Meeting of the Australasian Proteomics Society, and the South Australian Representative of the Australian Peptide Society.

Peter obtained his PhD in Analytical Chemistry from Saarland University, Germany in 1999. He came to the University of Adelaide in 2005 to establish the Adelaide Proteomics Centre. He has published over 85 papers in refereed journals and raised approximately $8.9M for research. Peter’s research is focussed on biomarker discovery in cancer, detection of protein phosphorylation and Tissue Imaging Mass Spectrometry. He recently formed the spin out company Onco DX to commercialise patented biomarkers for the early detection of ovarian and gastric cancer.

In the last 10 years my research has focused on the identification of low abundant proteins and the mapping of their posttranslational modifications as one of the biggest challenges in proteomics. I was the first to use free flow electrophoresis in a 3 dimensional separation approach to identify low abundant proteins from complex protein mixtures. I have contributed important methods for the identification of phosphorylation sites in proteins by mass spectrometry.

My knowledge in Proteomics, quantitative mass spectrometry and biomarker discovery led to Membership of Proteomics Australia (NCRIS 5.16). My laboratory the Adelaide Proteomics Centre is the National NCRIS node for Tissue Imaging Mass Spectrometry. My group is the leading group in Australia and South East Asia on Tissue Imaging Mass spectrometry and on the detection and identification of tyrosine phosphorylation in proteins. We were the first to use and publish Imaging Mass Spectrometry (IMS) techniques in Australia. We were also the first in Australia to produce data on Peptide Imaging Mass spectrometry and the use of this technology on formalin-fixed paraffin-embedded ovarian cancer tissue. My group is the leading group in using MALDI TOF MS technology in the country and the Biotyper technology is using MALDI TOF MS and is very closely related to Imaging Mass Spectrometry.

 

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  • Appointments

    Date Position Institution name
    2015 Professor University of Adelaide
    2012 Director, National NCRIS facility for Tissue Imaging Mass Spectrometry University of Adelaide
    2012 Deputy Director, Institute for Photonics and Advanced Sensing (IPAS) University of Adelaide
    2012 - 2014 Associate Professor University of Adelaide
    2005 Director, Adelaide Proteomics Centre University of Adelaide
    2005 - 2012 Senior Lecturer University of Adelaide
    2003 - 2005 Postdoctoral Fellow University of Leipzig
    2001 - 2003 Head, Proteomics Unit St Vincent’s Institute of Medical Research
    1999 - 2001 Postdoctoral Fellow Ludwig Institute For Cancer Research & The Walter and Eliza Hall Institute of Medical Research
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2005 Award Bio Innovation SA Directors Initiative
  • Education

    Date Institution name Country Title
    1999 Saarland University Germany PhD in Analytical Chemistry
    1995 Saarland University Germany Master’s degree, Diploma in Chemistry
Research Funding
Date Project/ No. Investigators Funding Body Amount
2016-2019 Tissue Imaging Mass Spectrometry NCRIS Node P Hoffmann Federal Government $204,000
2016-2018 Ovarian blood markers of ovarian cancer MK Oehler, P Hoffmann Ovarian Cancer Foundation $353,800
2016-2017 Autoantibody biomarkers for ovarian cancer detection MK Oehler, P Hoffmann Ovarian Cancer Foundation $178,218
2016-2019 Enhanced sensitivity of electrospray ionization mass spectrometry H Ebendorff-Heidepriem, Y Stokes, P Hoffmann, A Gooley Australian Research Council (ARC), Linkage Project, LP160100657 $500,000
2015 Validating an ELISA diagnostic for early stage gastric cancer P Hoffmann Adelaide Research & Innovation (ARI), Commercial Accelerator Scheme $50,000
2014-2015 Ovarian blood proteomic signatures of ovarian cancer MK Oehler, P Hoffmann Ovarian Council Research Foundation (OCRF) $350,000
2014-2015 Autoantibody biomarkers for ovarian cancer detection MK Oehler, P Hoffmann Ovarian Council Research Foundation (OCRF) $265,000
2013-2015 NCRIS National Node for Tissue Imaging Mass Spectrometry in Proteomics P Hoffmann Bioplatforms Australia $400,000
2013-2015 High resolution label free peptide and lipid quantification in tissue and bio fluids by mass spectrometry P Hoffmann, K Stuehler, A Sickmann SA-Germany Collaboration Scheme $50,000
2013 Proteomic analysis of membrane proteins of Enterococcus faecalis V583 and an oral clinical isolate grown in continuous culture at pH 8 & pH11" PR Cathro, P Zilm,N Gully, P Hoffmann

The Australian Dental Research Foundation

$10,506
2013

Establishment of the Protein Quantitation Centre of South Australia: PQCSA

P Hoffmann, T Chataway, J Bowie, G Fincher, M Brown, T Pukala, D Brooks, C Franco, D Keating, L Cosgrove, K Fung, M Herderich, W Hines Australian Research Council (ARC), LIEF, LE130100199 $475,000
2012 Identification of novel biomarkers from ovarian cancer populations enriched in stem cell properties P Hoffmann, RY-J Huang, JP Thiery, S Mori, MK Oehler Ovarian Cancer Research Foundation (OCRF) $60,000
2011-2014   P Hoffmann Strategic Investments in Science & Research (SIP), Department of Further Education, Employment, Science & Technology (DFEEST), Government of South Australia $450,000
2011 Development of an ovarian cancer tryptic peptide database for application in MALDI Imaging mass spectrometry (IMS)

MK Oehler, P Hoffmann

Ovarian Cancer Research Foundation (OCRF) $50,000
2011-2013 A novel approach to predict metastatic potential of prostate cancer WD Tilley, M Butler, P Hoffman, G Goodall, H Scher, V Marshall, P Sutherland, M Thomas Cancer Australia $591,000
2011-2013 Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using          tissue P Hoffmann, S McColl, M Pelzing Australian Research Council (ARC), Linkage Project, LP110100693 $300,000
2011-2013 Investigating signalling pathways that mediate suppression of anoikis by chemokine receptors in metastatic breast cancer cells S McColl, M Kochetkova, P Hoffmann

National Health and Medical Research Council (NHMRC), APP1012418

$576,732
2011-2013 Development of high-throughput screening assays for detecting early gastric cancer: translating proteomics research into clinical outcomes using emerging mass spectrometry and photonics technologies P Hoffmann, T Monro, A Boussioutas National Health and Medical Research Council (NHMRC), APP1010728 $633,416
2011-2013 NCRIS: National Node for Tissue Imaging Mass spectrometry in Proteomics P Hoffmann Bioplatforms Australia $900,000
2010-2012 Disruptive approaches to biological sensing
 
T Monro, C Sumby, H Ebendorff-Heidepriem, P Hoffmann, A Abell
Australian Research Council (ARC), Super science Fellowship Round 1, FS100100039 $835,000
2010-2012 Mitogenic and metabolic signalling via the insulin recptor isoform-A B Forbes, L Martin, P Hoffmann, J Wallace National Health and Medical Research Council (NHMRC), 627210 $544,500
2009-2012 Proteomic analysis of central nervous system inflammation in multiple sclerosis S McColl, P Hoffmann, C Bernard, B Carroll, J Greer, I Smith Australian Research Council (ARC), Linkage Project, LP0990788 $675,000
2010 Imaging Mass Spectrometry of Early Ovarian Cancer MK Oehler, P Hoffmann Ovarian Cancer Research Foundation (OCRF) $45,000
2009 The Use of MALDI Mass spectrometry and Biotyper software to identify oral bacteria P Zilm, P Hoffmann Australian Dental Research Foundation $6,000
2009 South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility JH Bowie, A Ball, DA Brooks, MA Buntine, T Chataway, P Hoffmann, WD Lawrance, AF Lopez, SR McColl, JO Miners, NH Voelcker Australian Research Council (ARC), Linkage Infrastructure, Equipment and Facility (LIEF), LE0989374 $550,000
2009 Autoantibodies in Ovarian Cancer: Their potential use as diagnostic makers MK Oehler, P Hoffmann Ovarian Cancer Research Foundation (OCRF) $24,000
2008 Facility for matrix deposition on tissue sections for imaging mass spectrometry P Hoffmann National Health and Medical Research Council (NHMRC), Equipment Grant, 580008 $29,000
2008 Profiling of the Immunoproteome in Early Ovarian Cancer MK Oehler, P Hoffmann RAH/IMVS, Clinical Project Grant $21,600
2008 Characterisation of citrullinated peptides in rheumatoid synovial fluid and removal by synovial lavage LG Cleland, SR McColl, P Hoffmann RAH/IMVS, Clinical Project Grant $10,000
2008 Proteomics of Ovarian Cancer Implantation MK Oehler, P Hoffmann Ovarian Cancer Research Foundation $40,000
2007-2010 Validation of Stat3 as a therapeutic target in diseases arising from its inappropriate activation by gp130 cytokines MR Ernst, P Hoffmann National Health and Medical Research Council (NHMRC), Project Grant, 433617 $645,250

 

Recent Teaching:
  • Adv Molecular Biology IIA (Biochem) (2015-2016)
  • Mol. & Struct. Biol.III (Biochem) (2014-2016)
  • Adv. Mol. Biol. IIIA (Biochem) (2014-2016)
  • Mol & Struc Biol (Biomed) (2014-2016)
  • Advanced Research Platforms (2014-2016)
  • Environ & Analytical Chem II (2014-2016)
  • Mol Struct Determination III (2014-2016)
  • Med. Biol. Chem. III (2009-2014)
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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Co-Supervisor Non-Mendelian Effects in Embryo-Fetal Development Doctor of Philosophy Doctorate Full Time Mrs Hanh Thi Hong Nguyen
    2016 Principal Supervisor Characterising the Proteom of Invasive and Metastatic Ovarian Cancer Cells Doctor of Philosophy Doctorate Full Time Mitchell Aidan Acland
    2015 Co-Supervisor Analysis of In-Vitro Aggregation of Therapeutic Proteins Using immobility Mass Spectrometry Doctor of Philosophy Doctorate Part Time Mr Paritosh Kumar Tripathi
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 - 2018 Principal Supervisor Painting a Picture of the Ovarian Cancer N-Glycome Doctor of Philosophy Doctorate Full Time Matthew Thomas Briggs
    2014 - 2018 Principal Supervisor Proteomics characterization of HPV-independent Vulvar Cancer Tumor Progression and Metastasis by Mass Spectrometry Doctor of Philosophy Doctorate Full Time Mr Chao Zhang
    2014 - 2016 Co-Supervisor Clustering of Proteomics Imaging Mass Spectrometry Data Master of Philosophy Master Full Time Miss Annie Conway
    2014 - 2017 Principal Supervisor Molecular Characterization of Metastatic Endometrial Cancer by Mass Spectrometry Doctor of Philosophy Doctorate Full Time Ms Parul Mittal
    2013 - 2018 Co-Supervisor Examination of Placenta and Child Saliva Samples Associated with Childhood Allergy Development Doctor of Philosophy Doctorate Full Time Dr Nurul Hayati Mohamad Zainal
    2012 - 2018 Co-Supervisor Role of Insulin Receptor Isoform A in Breast Cancer Doctor of Philosophy Doctorate Full Time Mr Liang Li
    2012 - 2015 Co-Supervisor The role and regulation of the p84 adaptor subunit in phosphatidylinositol 3-kinase gamma lipid-kinase signalling and the control of PI3Kgamma-dependent cell migration Doctor of Philosophy Doctorate Full Time Ms Michelle Elizabeth Turvey
    2012 - 2016 Co-Supervisor Statistical Treatment of Proteomic Imaging Mass Spectrometry Data Doctor of Philosophy Doctorate Full Time Mr Lyron Juan Winderbaum
    2010 - 2015 Principal Supervisor Utilising Quantitative Immunoproteomics To Reveal Differential Autoantibody Biomarker Panels In Serous Ovarian Cancer Patients Doctor of Philosophy Doctorate Full Time Mrs Karina Martin
    2009 - 2013 Co-Supervisor MOLECULAR MECHANISMS OF INSULIN RECEPTOR ISOFORM-A SIGNALLING Doctor of Philosophy Doctorate Full Time Mr Kolin Harinda Rajapaksha
    2008 - 2012 Principal Supervisor Molecular Characterization of Metastatic Ovarian Cancer by MALDI Imaging Mass Spectrometry Doctor of Philosophy Doctorate Full Time Mr Ove Gustafsson
    2008 - 2014 Co-Supervisor "Understanding the Apoptotic Signaling Pathway that Involve In Breast Cancer Using Microarray, Proteomics and Bioinformatics Doctor of Philosophy Doctorate Full Time Mr Ibrahim Oqla Alanazi
    2007 - 2011 Co-Supervisor The Differential Roles of p101 and p84, the Regulatory Subunits of Phosphoinositide 3-kinase Gamma, in Cell Migration Doctor of Philosophy Doctorate Full Time Miss Julie Brazzatti
    2006 - 2014 Co-Supervisor Characteristic Negative Ion Fragmentations of Deprotonated Peptides Containing Post-Translational Modifications Doctor of Philosophy Doctorate Full Time Ms Hayley Andreazza
    2006 - 2012 Co-Supervisor Clinical and Biological Determinants of the Coronary Slow Flow Phenomenon Doctor of Philosophy Doctorate Part Time Miss Victoria Kopetz
    2006 - 2011 Co-Supervisor Casein Proteins: Investigating Their Chaperone Activity And Amyloid Fibril Formation Doctor of Philosophy Doctorate Full Time Mr Tomas Koudelka
    2006 - 2011 Principal Supervisor Development of Sensitive Proteomic Approaches for Protein Tyrosine Phosphorylation Detection Doctor of Philosophy Doctorate Full Time Mr Mark Condina
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  • Committee Memberships

    Date Role Committee Institution Country
    2014 - 2014 Chair Session Chair and Session Organiser, Analytica Conference Munich Germany
    2012 - 2016 Vice-President Lorne Proteomics Symposium Australia
    2012 - 2016 Chair Lorne Proteomics Symposium Australia
    2009 - ongoing Member Organising Committee, Australian Peptide Conference Australia
    2009 - 2011 Chair Multiple Session Chairs, Australian Peptide Conference Australia
    2007 - 2011 Chair Multiple Session Chairs, Lorne Proteomics Symposium Australia
  • Memberships

    Date Role Membership Country
    2015 - ongoing Member Human Proteome Organization (HUPO) Council
    2012 - ongoing Vice-President Australasian Proteomics Society
    2007 - ongoing Representative Australian Peptide Association Australia
    2007 - ongoing Member Human Proteome Organization (HUPO)
    2006 - ongoing Representative Australian Proteomics Society Australia
  • Consulting/Advisories

    Date Institution Department Organisation Type Country
    2015 - 2015
    2009 - 2009 Scientific research Australia
    2006 - ongoing Scientific research Australia
    2006 - ongoing Scientific research Australia
    2006 - ongoing Scientific research Germany
    2006 - ongoing Scientific research Australia
  • Position: Prof Bio Sci - Dir Adelaide Proteomics Ct
  • Phone: 83135507
  • Email: peter.hoffmann@adelaide.edu.au
  • Fax: 8313 4362
  • Campus: North Terrace
  • Building: Molecular Life Sciences, floor 1
  • Room: 1 49
  • Org Unit: Molecular and Biomedical Science

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