Matthew Briggs

Research Interests

Glycobiology Analytical Chemistry Proteomics and metabolomics

Dr Matthew Briggs

ARC Grant-Funded Researcher B

School of Agriculture, Food and Wine

College of Sciences

Dr Matthew Briggs is an expert in Glycomics & Lipidomics currently working as an ARC Grant-Funded Researcher (B) at Adelaide University under Professor Jenny Mortimer. Previously, he worked as an Associate Research Fellow at the University of Wollongong under Associate Professor Shane Ellis (2024-2025) and as a Postdoctoral Research Associate at the University of South Australia under Professor Peter Hoffmann (2018-2024). 
 
Matthew received his PhD (2018), Bachelor of Science (Honours) (2014), Bachelor of Science (Molecular Biology) (2013) and Diploma of Languages (Indonesian) (2013), all from the University of Adelaide. Since graduating, he has published 25 scientific publications in peer reviewed journals, ranging from research articles and literature reviews to book chapters and opinion pieces, including in Analytical Chemistry, Food Chemistry and Food Reviews International. 
 
Matthew has also had the fortunate opportunity to present his work at over 15 national and international conferences, including the Annual Lorne Proteomics Symposium (since 2014), the Australasian Glycoscience Symposium (since 2018), the Human Proteome Organization World Congress (2015, 2019), the International Mass Spectrometry Imaging Society Conference (2023), the International Mass Spectrometry Conference (2024), and most recently, the American Society for Mass Spectrometry Conference (2025). 
 
In 2019, Matthew was awarded a University of South Australia Future Industries Accelerator Mobility Grant to design and develop a novel cost-effective and time-efficient MALDI-MS workflow as a Visiting Research Associate at CSL Limited, one of the world’s largest biopharmaceutical companies. 

As part of the ARC Research Hub for Engineering Plants to Replace Fossil Carbon, led by the University of Queensland, new plant varieties will be developed to sustainably produce sugars from crop 'waste' for renewable carbon products, such as cost-effective and sustainable aviation fuel 🌱✈️

At Adelaide University, I will be responsible for developing and running analytical methods to deliver detailed plant cell wall characterisation of a range of crops, including sorghum, sugar cane and rice 🍚🕵️

This will include monosaccharide quantification using HPAEC-PAD, structural analysis of polysaccharides using PACE and MALDI/ESI, and lignin composition using GC-MS 💥📊

Date Position Institution name
2025 - ongoing ARC Grant-Funded Researcher (Level B) University of Adelaide
2024 - 2025 Associate Research Fellow University of Wollongong
2018 - 2024 Postdoctoral Research Associate University of South Australia

Date Type Title Institution Name Country Amount
2017 Award Best Student Paper Institute of Photonics and Advanced Sensing Australia -
2016 Award Best Student Paper Australian Society for Biochemistry and Molecular Biology Australia -

Date Institution name Country Title
2015 - 2018 University of Adelaide Australia PhD
2014 - 2014 University of Adelaide Australia Bachelor of Science (Honours)
2010 - 2013 University of Adelaide Australia Bachelor of Science (Molecular Biology)
2010 - 2013 University of Adelaide Australia Diploma of Languages (Indonesian)

Year Citation
2025 Lau, D., Donnellan, L., Briggs, M., Klingler Hoffmann, M., & Hoffmann, P. (2025). MALDI Mass spectrometry imaging of metabolites in cereal grains and legumes: repurposing for industrial applications. Food Reviews International, 41(4), 1200-1221.
DOI Scopus4 WoS4
2025 Ngai, Y. T., Young, C., Parkinson-Lawrence, E. J., Wimmer-Kleikamp, S., Mittal, P., Beard, H., . . . Hoffmann, P. (2025). Defining lung pathogenesis in a murine model of mucopolysaccharidosis Type I by proteomic analysis. Molecular Genetics and Metabolism, 146(1-2), 109231.
DOI
2024 Lau, W. C. D., Donnellan, L., Briggs, M., Rupasinghe, T., Harris, J. C., Hayes, J. E., & Hoffmann, P. (2024). Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats. Food Chemistry, 433(137275), 1-10.
DOI Scopus14 WoS14 Europe PMC9
2024 Li, C. M. Y., Briggs, M. T., Lee, Y. -R., Tin, T., Young, C., Pierides, J., . . . Fenix, K. (2024). Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.. Clin Exp Med, 24(1), 53.
DOI Scopus9 WoS10 Europe PMC8
2024 Ngai, Y. T., Briggs, M. T., Mittal, P., Young, C., Parkinson-Lawrence, E., Klingler-Hoffmann, M., . . . Hoffmann, P. (2024). Mass spectrometry imaging protocol for spatial mapping of lipids, N-glycans and peptides in murine lung tissue. Rapid Communications in Mass Spectrometry, 38(9), e9721.
DOI Scopus6 WoS6 Europe PMC3
2023 Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). Complex-Type <i>N</i>-Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients. Journal of Proteome Research, 22(8), 2694-2702.
DOI Scopus4 WoS4 Europe PMC4
2023 Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). High-Resolution <i>N</i>-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis. Analytical Chemistry, 95(34), 12575-12992.
DOI Scopus6 WoS6 Europe PMC6
2022 Lee, Y. -R., Briggs, M. T., Young, C., Condina, M. R., Kuliwaba, J. S., Anderson, P. H., & Hoffmann, P. (2022). Mass spectrometry imaging spatially identifies complex-type N-glycans as putative cartilage degradation markers in human knee osteoarthritis tissue. Analytical and Bioanalytical Chemistry, 414(26), 7597-7607.
DOI Scopus9 WoS9 Europe PMC7
2022 McNab, J. M., Briggs, M. T., Williamson, J. E., Hoffmann, P., Rodriguez, J., & Karuso, P. (2022). Structural Characterization and Spatial Mapping of Tetrodotoxins in Australian Polyclads. Marine Drugs, 20(12), 15 pages.
DOI Scopus6 WoS6 Europe PMC2
2021 Dilmetz, B. A., Lee, Y. R., Condina, M. R., Briggs, M., Young, C., Desire, C. T., . . . Hoffmann, P. (2021). Novel technical developments in mass spectrometry imaging in 2020: A mini review. Analytical Science Advances, 2(3-4), 225-237.
DOI Scopus28 WoS27 Europe PMC27
2021 Lee, Y. R., Briggs, M. T., Kuliwaba, J. S., Anderson, P. H., Condina, M. R., & Hoffmann, P. (2021). Gelatin-coated indium tin oxide slides improve human cartilage-bone tissue adherence and N-glycan signal intensity for mass spectrometry imaging. Analytical and Bioanalytical Chemistry, 413(10), 2675-2682.
DOI Scopus15 WoS15 Europe PMC11
2021 Mittal, P., Briggs, M., Klingler-Hoffmann, M., Kaur, G., Packer, N. H., Oehler, M. K., & Hoffmann, P. (2021). Altered N-linked glycosylation in endometrial cancer. Analytical and Bioanalytical Chemistry, 413(10), 2721-2733.
DOI Scopus22 WoS22 Europe PMC23
2021 Young, C., Condina, M. R., Briggs, M. T., Moh, E. S. X., Kaur, G., Oehler, M. K., & Hoffmann, P. (2021). In-House Packed Porous Graphitic Carbon Columns for Liquid Chromatography-Mass Spectrometry Analysis of <i>N-</i>Glycans.. Frontiers in chemistry, 9(article no. 653959), 653959.
DOI Scopus19 WoS17 Europe PMC14
2020 Lee, Y. R., Briggs, M. T., Condina, M. R., Puddy, H., Anderson, P. H., Hoffmann, P., & Kuliwaba, J. S. (2020). Mass spectrometry imaging as a potential tool to investigate human osteoarthritis at the tissue level. International Journal of Molecular Sciences, 21(17), 6414-1-6414-13.
DOI Scopus16 WoS14 Europe PMC12
2019 Briggs, M. T., Condina, M. R., Klingler-Hoffmann, M., Arentz, G., Everest-Dass, A. V., Kaur, G., . . . Hoffmann, P. (2019). Translating N-Glycan Analytical Applications into Clinical Strategies for Ovarian Cancer. Proteomics - Clinical Applications, 13(3), 1-5.
DOI Scopus23 WoS18 Europe PMC15
2019 Briggs, M. T., Condina, M. R., Ho, Y. Y., Everest-Dass, A. V., Mittal, P., Kaur, G., . . . Hoffmann, P. (2019). MALDI mass spectrometry imaging of early- and late-stage serous ovarian cancer tissue reveals stage-specific N-glycans. Proteomics, 19(21-22), 1800482-1-1800482-11.
DOI Scopus54 WoS48 Europe PMC45
2019 Horan, M. P., Hoffmann, P., Briggs, M. T., Condina, M., Herbert, S., Ito, J., . . . Badrick, T. (2019). An external quality assurance trial to assess mass spectrometry protein testing facilities for identifying multiple human peptides. Analytical and bioanalytical chemistry, 411(25), 6575-6581.
DOI Scopus2 WoS1 Europe PMC1
2019 Chatterjee, S., Lee, L. Y., Kawahara, R., Abrahams, J. L., Briggs, M. T., Hoffman, P., & Thaysen Andersen, M. (2019). Protein paucimannosylation is an enriched N-Glycosylation signature of human cancers. Proteomics, 19(21-22, article no. 1900010), 1-13.
DOI Scopus64 WoS70 Europe PMC61
2019 Condina, M. R., Mittal, P., Briggs, M. T., Oehler, M. K., Klingler-Hoffmann, M., & Hoffmann, P. (2019). Egg white as a quality control in matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).. Analytical chemistry, 91(23), 14846-14853.
DOI Scopus13 WoS14 Europe PMC12
2018 Gustafsson, O. J. R., Briggs, M. T., Condina, M. R., Winderbaum, L. J., Pelzing, M., McColl, S. R., . . . Hoffmann, P. (2018). Raw N-glycan mass spectrometry imaging data on formalin-fixed mouse kidney. Data in Brief, 21, 185-188.
DOI Scopus4 WoS3 Europe PMC3
2017 Briggs, M., Ho, Y., Kaur, G., Oehler, M., Everest-Dass, A., Packer, N., & Hoffmann, P. (2017). N-Glycan matrix-assisted laser desorption/ionization mass spectrometry imaging protocol for formalin-fixed paraffin-embedded tissues. Rapid Communications in Mass Spectrometry, 31(10), 825-841.
DOI Scopus25 WoS23 Europe PMC21
2016 Briggs, M., Kuliwaba, J., Muratovic, D., Everest-Dass, A., Packer, N., Findlay, D., & Hoffmann, P. (2016). MALDI mass spectrometry imaging of N-glycans on tibial cartilage and subchondral bone proteins in knee osteoarthritis. Proteomics, 16(11-12), 1736-1741.
DOI Scopus45 WoS43 Europe PMC40
2016 Everest-Dass, A., Briggs, M., Kaur, G., Oehler, M., Hoffmann, P., & Packer, N. (2016). N-glycan MALDI imaging mass spectrometry on formalin-fixed paraffin-embedded tissue enables the delineation of ovarian cancer tissues. Molecular and Cellular Proteomics, 15(9), 3003-3016.
DOI Scopus112 WoS108 Europe PMC98
2015 Gustafsson, O., Briggs, M., Condina, M., Winderbaum, L., Pelzing, M., McColl, S., . . . Hoffmann, P. (2015). MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney. Analytical and Bioanalytical Chemistry, 407(8), 2127-2139.
DOI Scopus77 WoS77 Europe PMC69

Science
Year Grant Funding Source Amount (AUD)
2024 Early-Mid Career Researcher Enabling Grant University of Wollongong $2,922
2019 Future Industries Accelerator Mobility Grant University of South Australia $56,174

Arts
Year Grant Funding Source Amount (AUD)
2022 Independent Artist Project Grant CreateSA $19,818
2022 Triennial Funding Grant CreateSA $120,000
2021 Independent Artist Project Grant CreateSA $18,408
2021 Restart Investment to Sustain and Expand Fund Creative Australia $15,000
2021 South Australian Producer Grant Adelaide Fringe Festival $4,950
2021 Make It Happen Grant Adelaide Fringe Festival $5,000
2020 Science-Arts Collaboration Grant Inspiring South Australia $6,900
2020 Quick Response Grant James & Diana Ramsay Foundation $2,000
2019 Artist Fund Grant Adelaide Fringe Festival $10,000

 

 

 

Year Students Institution  Type of Teaching
2022 - 2023 1st Year Biomedical Science University of South Australia Demonstrator
2016 - 2017 3rd Year Biochemistry & Chemistry University of Adelaide Demonstrator

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2022 - 2025 Co-Supervisor Investigating oat (Avena sativa L.) lipid regulation through the lens of mass spectrometry University of South Australia - Doctorate - Darren Lau
2020 - 2023 Co-Supervisor Tissue-specific N-glycan alterations in human knee osteoarthritis discovered by MALDI Mass Spectrometry Imaging University of South Australia - Doctorate - Yea-Rin Lee

Date Role Committee Institution Country
2024 - 2025 Representative Operations and Communications Australian Glycoscience Society Australia

Date Role Membership Country
2025 - ongoing Member Australian Society of Plant Scientists Australia
2019 - ongoing Member Australian Glycoscience Society Australia

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