Matthew Briggs

Research Interests

Glycobiology Analytical Chemistry Proteomics and metabolomics

Dr Matthew Briggs

ARC Grant-Funded Researcher B

School of Agriculture, Food and Wine

College of Science

Available For Media Comment.

Dr Matthew Briggs is an expert in Glycomics & Lipidomics currently working as an ARC Grant-Funded Researcher (B) at Adelaide University under Professor Jenny Mortimer. Previously, he worked as an Associate Research Fellow at the University of Wollongong under Associate Professor Shane Ellis (2024-2025) and as a Postdoctoral Research Associate at the University of South Australia under Professor Peter Hoffmann (2018-2024). 
 
Matthew received his PhD (2018), Bachelor of Science (Honours) (2014), Bachelor of Science (Molecular Biology) (2013) and Diploma of Languages (Indonesian) (2013), all from the University of Adelaide. Since graduating, he has published 25 scientific publications in peer reviewed journals, ranging from research articles and literature reviews to book chapters and opinion pieces, including in Analytical Chemistry, Food Chemistry and Food Reviews International. 
 
Matthew has also had the fortunate opportunity to present his work at over 15 national and international conferences, including the Annual Lorne Proteomics Symposium (since 2014), the Australasian Glycoscience Symposium (since 2018), the Human Proteome Organization World Congress (2015, 2019), the International Mass Spectrometry Imaging Society Conference (2023), the International Mass Spectrometry Conference (2024), and most recently, the American Society for Mass Spectrometry Conference (2025). 
 
In 2019, Matthew was awarded a University of South Australia Future Industries Accelerator Mobility Grant to design and develop a novel cost-effective and time-efficient MALDI-MS workflow as a Visiting Research Associate at CSL Limited, one of the world’s largest biopharmaceutical companies. 

I am part of the $4.93 million ARC Research Hub for Engineering Plants to Replace Fossil Carbon (2025-2030), led by the University of Queensland 🌾🧬

The ARC Hub aims to develop new genetic varieties of plants that enable the sustainable production of sugars from crop ‘waste’ (plant biomass), providing a renewable carbon source for a new generation of products. By bringing together emerging technologies, foundational research and world-leading expertise, the ARC Hub aims to translate this science into cost-effective, sustainable aviation fuel 🌱✈️

This research has the potential to create new opportunities for agricultural producers, while supporting industries that convert plant biomass into high-value renewable products. Ultimately, the ARC Hub aims to contribute to a decarbonised pathway for Australia’s critical flight, freight and defence connections, while creating significant economic returns and new manufacturing jobs in Australia 🐨♻️

At Adelaide University, my role is to decipher the molecular composition and structure of plant biomass by developing and applying analytical chemistry methods to characterise plant cell walls and understand how their composition varies between crops. This will help identify and develop sorghum, sugarcane and rice biomass that can be more efficiently converted into renewable carbon products 🍚🕵️

Techniques that I have developed and applied include monosaccharide quantification by HPAEC-PAD, structural analysis of polysaccharides by PACE, MALDI-MS and ESI-MS, total lignin quantification by UV-Vis Spectroscopy, and lignin compositional analysis by TGA and GC-MS 🔥📊

Date Position Institution name
2025 - ongoing ARC Grant-Funded Researcher (Level B) Adelaide University
2024 - 2025 Associate Research Fellow University of Wollongong
2018 - 2024 Postdoctoral Research Associate University of South Australia

Date Type Title Institution Name Country Amount
2023 Nomination Ruby Award Finalist for Outstanding Work, Event or Project for Young People CreateSA Australia -
2021 Award Weekly Best Visual Art & Design Award Adelaide Fringe Festival Australia -
2021 Award Weekly Adelaide Critics Circle Award Adelaide Fringe Festival Australia -
2021 Award Weekly Best Theatre Award Adelaide Fringe Festival Australia -
2021 Award Best Theatre Award The Advertiser Australia -
2021 Nomination Best Melbourne Documentary Finalist Melbourne Documentary Film Festival Australia -
2021 Award The Audience Award Mental Filmness United States -
2021 Award Lived Experience Award This Is My Brave Film Festival United States -
2019 Award Weekly John Chataway Innovation Award Adelaide Fringe Festival Australia -
2019 Award Best Emerging Producer Award Adelaide Fringe Festival Australia -
2019 Award Adelaide Festival Centre inSPACE Development Award Adelaide Fringe Festival Australia -
2018 Award Weekly Best Cabaret Award Adelaide Fringe Festival Australia -
2017 Award Best Student Paper Institute of Photonics and Advanced Sensing Australia -
2016 Award Best Student Paper Australian Society for Biochemistry and Molecular Biology Australia -

Date Institution name Country Title
2015 - 2018 University of Adelaide Australia PhD
2014 - 2014 University of Adelaide Australia Bachelor of Science (Honours)
2010 - 2013 University of Adelaide Australia Bachelor of Science (Molecular Biology)
2010 - 2013 University of Adelaide Australia Diploma of Languages (Indonesian)

Year Citation
2025 Lau, D., Donnellan, L., Briggs, M., Klingler Hoffmann, M., & Hoffmann, P. (2025). MALDI Mass spectrometry imaging of metabolites in cereal grains and legumes: repurposing for industrial applications. Food Reviews International, 41(4), 1200-1221.
DOI Scopus5 WoS5
2025 Ngai, Y. T., Young, C., Parkinson-Lawrence, E. J., Wimmer-Kleikamp, S., Mittal, P., Beard, H., . . . Hoffmann, P. (2025). Defining lung pathogenesis in a murine model of mucopolysaccharidosis Type I by proteomic analysis. Molecular Genetics and Metabolism, 146(1-2), 109231.
DOI Scopus1 WoS1
2024 Lau, W. C. D., Donnellan, L., Briggs, M., Rupasinghe, T., Harris, J. C., Hayes, J. E., & Hoffmann, P. (2024). Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats. Food Chemistry, 433(137275), 1-10.
DOI Scopus19 WoS19 Europe PMC9
2024 Li, C. M. Y., Briggs, M. T., Lee, Y. -R., Tin, T., Young, C., Pierides, J., . . . Fenix, K. (2024). Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.. Clin Exp Med, 24(1), 53.
DOI Scopus13 WoS14 Europe PMC8
2024 Ngai, Y. T., Briggs, M. T., Mittal, P., Young, C., Parkinson-Lawrence, E., Klingler-Hoffmann, M., . . . Hoffmann, P. (2024). Mass spectrometry imaging protocol for spatial mapping of lipids, N-glycans and peptides in murine lung tissue. Rapid Communications in Mass Spectrometry, 38(9), e9721.
DOI Scopus6 WoS6 Europe PMC4
2023 Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). Complex-Type <i>N</i>-Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients. Journal of Proteome Research, 22(8), 2694-2702.
DOI Scopus4 WoS4 Europe PMC4
2023 Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). High-Resolution <i>N</i>-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis. Analytical Chemistry, 95(34), 12575-12992.
DOI Scopus7 WoS8 Europe PMC7
2022 Lee, Y. -R., Briggs, M. T., Young, C., Condina, M. R., Kuliwaba, J. S., Anderson, P. H., & Hoffmann, P. (2022). Mass spectrometry imaging spatially identifies complex-type N-glycans as putative cartilage degradation markers in human knee osteoarthritis tissue. Analytical and Bioanalytical Chemistry, 414(26), 7597-7607.
DOI Scopus9 WoS10 Europe PMC9
2022 McNab, J. M., Briggs, M. T., Williamson, J. E., Hoffmann, P., Rodriguez, J., & Karuso, P. (2022). Structural Characterization and Spatial Mapping of Tetrodotoxins in Australian Polyclads. Marine Drugs, 20(12), 15 pages.
DOI Scopus6 WoS6 Europe PMC2
2021 Lee, Y. R., Briggs, M. T., Kuliwaba, J. S., Anderson, P. H., Condina, M. R., & Hoffmann, P. (2021). Gelatin-coated indium tin oxide slides improve human cartilage-bone tissue adherence and N-glycan signal intensity for mass spectrometry imaging. Analytical and Bioanalytical Chemistry, 413(10), 2675-2682.
DOI Scopus15 WoS15 Europe PMC11
2021 Mittal, P., Briggs, M., Klingler-Hoffmann, M., Kaur, G., Packer, N. H., Oehler, M. K., & Hoffmann, P. (2021). Altered N-linked glycosylation in endometrial cancer. Analytical and Bioanalytical Chemistry, 413(10), 2721-2733.
DOI Scopus24 WoS24 Europe PMC23
2021 Young, C., Condina, M. R., Briggs, M. T., Moh, E. S. X., Kaur, G., Oehler, M. K., & Hoffmann, P. (2021). In-House Packed Porous Graphitic Carbon Columns for Liquid Chromatography-Mass Spectrometry Analysis of <i>N-</i>Glycans.. Frontiers in chemistry, 9(article no. 653959), 653959.
DOI Scopus20 WoS17 Europe PMC15
2021 Dilmetz, B. A., Lee, Y. R., Condina, M. R., Briggs, M., Young, C., Desire, C. T., . . . Hoffmann, P. (2021). Novel technical developments in mass spectrometry imaging in 2020: A mini review. Analytical Science Advances, 2(3-4), 225-237.
DOI Scopus30 WoS29 Europe PMC27
2020 Lee, Y. R., Briggs, M. T., Condina, M. R., Puddy, H., Anderson, P. H., Hoffmann, P., & Kuliwaba, J. S. (2020). Mass spectrometry imaging as a potential tool to investigate human osteoarthritis at the tissue level. International Journal of Molecular Sciences, 21(17), 6414-1-6414-13.
DOI Scopus16 WoS15 Europe PMC13
2019 Briggs, M. T., Condina, M. R., Klingler-Hoffmann, M., Arentz, G., Everest-Dass, A. V., Kaur, G., . . . Hoffmann, P. (2019). Translating N-Glycan Analytical Applications into Clinical Strategies for Ovarian Cancer. Proteomics - Clinical Applications, 13(3), 1-5.
DOI Scopus23 WoS19 Europe PMC15
2019 Briggs, M. T., Condina, M. R., Ho, Y. Y., Everest-Dass, A. V., Mittal, P., Kaur, G., . . . Hoffmann, P. (2019). MALDI mass spectrometry imaging of early- and late-stage serous ovarian cancer tissue reveals stage-specific N-glycans. Proteomics, 19(21-22), 1800482-1-1800482-11.
DOI Scopus57 WoS51 Europe PMC45
2019 Horan, M. P., Hoffmann, P., Briggs, M. T., Condina, M., Herbert, S., Ito, J., . . . Badrick, T. (2019). An external quality assurance trial to assess mass spectrometry protein testing facilities for identifying multiple human peptides. Analytical and bioanalytical chemistry, 411(25), 6575-6581.
DOI Scopus2 WoS1 Europe PMC1
2019 Chatterjee, S., Lee, L. Y., Kawahara, R., Abrahams, J. L., Briggs, M. T., Hoffman, P., & Thaysen Andersen, M. (2019). Protein paucimannosylation is an enriched N-Glycosylation signature of human cancers. Proteomics, 19(21-22, article no. 1900010), 1-13.
DOI Scopus66 WoS72 Europe PMC65
2019 Condina, M. R., Mittal, P., Briggs, M. T., Oehler, M. K., Klingler-Hoffmann, M., & Hoffmann, P. (2019). Egg white as a quality control in matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI).. Analytical chemistry, 91(23), 14846-14853.
DOI Scopus13 WoS14 Europe PMC12
2018 Gustafsson, O. J. R., Briggs, M. T., Condina, M. R., Winderbaum, L. J., Pelzing, M., McColl, S. R., . . . Hoffmann, P. (2018). Raw N-glycan mass spectrometry imaging data on formalin-fixed mouse kidney. Data in Brief, 21, 185-188.
DOI Scopus4 WoS3 Europe PMC3
2017 Briggs, M., Ho, Y., Kaur, G., Oehler, M., Everest-Dass, A., Packer, N., & Hoffmann, P. (2017). N-Glycan matrix-assisted laser desorption/ionization mass spectrometry imaging protocol for formalin-fixed paraffin-embedded tissues. Rapid Communications in Mass Spectrometry, 31(10), 825-841.
DOI Scopus25 WoS23 Europe PMC21
2016 Briggs, M., Kuliwaba, J., Muratovic, D., Everest-Dass, A., Packer, N., Findlay, D., & Hoffmann, P. (2016). MALDI mass spectrometry imaging of N-glycans on tibial cartilage and subchondral bone proteins in knee osteoarthritis. Proteomics, 16(11-12), 1736-1741.
DOI Scopus46 WoS43 Europe PMC41
2016 Everest-Dass, A., Briggs, M., Kaur, G., Oehler, M., Hoffmann, P., & Packer, N. (2016). N-glycan MALDI imaging mass spectrometry on formalin-fixed paraffin-embedded tissue enables the delineation of ovarian cancer tissues. Molecular and Cellular Proteomics, 15(9), 3003-3016.
DOI Scopus116 WoS112 Europe PMC103
2015 Gustafsson, O., Briggs, M., Condina, M., Winderbaum, L., Pelzing, M., McColl, S., . . . Hoffmann, P. (2015). MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney. Analytical and Bioanalytical Chemistry, 407(8), 2127-2139.
DOI Scopus79 WoS78 Europe PMC69

Science
Year Grant Funding Source Amount (AUD)
2026 Small Capital Item Purchase Support Scheme: Vacuum Centrifuge (Dr. Matthew Briggs (Co-Lead), Dr. Sebastian Garcia-Daga)  Waite Research Institute $14,830
2024 Early-Mid Career Researcher Enabling Grant: Establishing N-glycan MALDI-MSI at the University of Wollongong (Dr. Matthew Briggs)  University of Wollongong $2,922
2019 Future Industries Accelerator (FIA) Mobility Grant: Developing a high-throughput MALDI-MS workflow for the relative quantitation of N-glycans labelled with procainamide (Dr. Matthew Briggs (Lead CI), Dr. Mark Condina, Dr. Matthias Pelzing (CSL Ltd.), Prof. Peter Hoffmann)  University of South Australia $56,174

Arts
Year Grant Funding Source Amount (AUD)
2026 Australian Performing Arts Exchange (APAX) Travel Bursary CreateSA $3,540
2022 Richard Llewellyn Grant: Happy-Go-Wrong (Space Theatre, Adelaide Festival Centre) CreateSA, Adelaide Festival Centre & Australian Cultural Fund $21,500
2022 Independent Artist Project Grant: Weight Stage 2 Creative Development (State Theatre Company of South Australia Rehearsal Room)  CreateSA $19,818
2021 - 2024 Triennial Funding Grant & Country Arts SA Project Grant: Guthrak (2023 DreamBIG Children's Festival & 2024 Regional South Australia Tour, with additional support from State Theatre Company of South Australia and Riverland Youth Theatre) CreateSA, Australian Government Regional Arts Fund, Regional Arts Australia, Country Arts SA & Adelaide Festival Centre $147,418
2021 Independent Artist Project Grant: Guthrak Stage 2 Creative Development (State Theatre Company of South Australia Rehearsal Room)  CreateSA $18,408
2021 Restart Investment to Sustain and Expand (RISE) Fund: Mental As Everything Documentary (SBS, Melbourne Documentary Film Festival, North Bellarine Film Festival, Mental Filmness, This Is My Brave Mental Health Film Festival, Thornbury Picture House, Reel Mind Film Festival)  Creative Australia $15,000
2021 Regional Victoria Tour: Mental As Everything (Kingston Arts Centre, Mount Beauty Community Centre, Bena Community Hall, The Forge Theatre & Arts Hub, West Gippsland Arts Centre, Potato Shed, Portland Arts Centre, Wonthaggi Union Community Arts Centre, Frankston Arts Centre, Lighthouse Theatre, Wyndham Cultural Centre & St Arnaud McDonald Hall, with additional seasons at the Adelaide Cabaret Festival, Tasmania's Festival of Voices, Chapel Off Chapel, Roxy Community Theatre & Kalamunda Performing Arts Centre) Regional Arts Victoria & Creative Victoria $60,040
2021 South Australian Producer Grant: Employing an Associate Producer, Jden Redden, for the 2021 Adelaide Fringe Adelaide Fringe Festival $4,950
2021 Make It Happen Grant: Happy-Go-Wrong (Bakehouse Theatre, 2021 Adelaide Fringe) Adelaide Fringe Festival $5,000
2020 inSPACE Development Program: Guthrak Stage 1 Creative Development (Online) Adelaide Festival Centre $5,000
2020 Science-Arts Collaboration Grant: SUGAR (praxis ARTSPACE, 2021 Adelaide Fringe) Inspiring South Australia $6,900
2020 COVID-19 Quick Response Grant James & Diana Ramsay Foundation $2,000
2019 Adelaide Fringe Artist Fund Grant, Helpmann Academy Regular Grant & Helpmann Academy Elevate Mentorship Grant: 30,000 Notes (nthspace Adelaide, 2019 Adelaide Fringe) Adelaide Fringe Festival, Helpmann Academy & Pozible $19,496

 

 

 

Year Students Institution  Type of Teaching
2022 - 2023 1st Year Biomedical Science University of South Australia Demonstrator
2016 - 2017 3rd Year Biochemistry & Chemistry University of Adelaide Demonstrator

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2022 - 2025 Co-Supervisor Investigating oat (Avena sativa L.) lipid regulation through the lens of mass spectrometry University of South Australia - Doctorate - Darren Lau
2020 - 2023 Co-Supervisor Tissue-specific N-glycan alterations in human knee osteoarthritis discovered by MALDI Mass Spectrometry Imaging University of South Australia - Doctorate - Yea-Rin Lee

Date Role Committee Institution Country
2024 - 2025 Representative Operations and Communications Australian Glycoscience Society Australia

Date Role Membership Country
2025 - ongoing Member Australian Society of Plant Scientists Australia
2019 - ongoing Member Australian Glycoscience Society Australia

Connect With Me

External Profiles

Other Links