Lisa Butler

Professor Lisa Butler

Cancer Council Principal Research Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Professor Lisa Butler
Cancer Council SA Beat Cancer Principal Cancer Research Fellow.

Professor Lisa Butler is a Cancer Council SA Beat Cancer Principal Cancer Research Fellow in the Freemasons Foundation Centre for Men's Health and the Adelaide Medical School at the University of Adelaide, and heads the Prostate Cancer Research Group at the South Australian Health and Medical Research Institute (SAHMRI). She holds key management positions in the Freemasons’ Foundation Centre for Men’s Health (FFCMH), the Centre for Personalized Cancer Medicine at the University of Adelaide and the Faculty of Health and Medical Sciences Research Committee and she co-directs the Adelaide Prostate Cancer Research Centre. Her postdoctoral studies, at Memorial Sloan-Kettering Cancer Center (New York, 1998-2001), directly contributed to the clinical development of histone deacetylase inhibitors as anticancer agents. Prof Butler has established an internationally-recognised research program focused on targeting androgen signalling in prostate cancer, discovering innovative biomarkers of response to treatment, and testing the efficacy of novel drugs for prostate cancer.

A major focus of her research program has been the development of preclinical models that more closely represent the individual responses in men with prostate cancer. She developed the unique ex vivo prostate tumor culture model, which has substantially enhanced her international profile and resulted in the adoption of the technique by scientists from the University of Leuven, Belgium, Thomas Jefferson University, Philadelphia, UT Southwestern, Dallas and the Royal Marsden Hospital, London. Prof Butler has used this model to demonstrate the anti-proliferative efficacy of the novel heat shock protein 90 inhibitor AUY922 and the cyclin dependent kinase inhibitor ribocyclib in prostate cancer tissues (Clin Cancer Res 18:3562), and funding was subsequently awarded by Cancer Australia in 2013 to translate these preclinical studies into a clinical trial of ribocyclib for prostate cancer. In 2014 she was awarded a Movember Revolutionary Team Award to investigate the role of lipids in prostate cancer and their potential for new biomarkers of disease aggressiveness. Her other major research interests include characterising the role of androgen receptor in prostate cancer and the development of combinatorial therapeutic strategies.

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  • Appointments

    Date Position Institution name
    2018 Cancer Council Principal Research Fellow University of Adelaide
    2014 - 2018 Australian Research Council Future Fellow University of Adelaide
    2012 - 2013 University Senior Research Fellow University of Adelaide
    2008 - 2012 Cancer Council SA Senior Research Fellow University of Adelaide
    2006 - 2008 Florey Research Fellow University of Adelaide
    2003 - 2005 Prostate Cancer Foundation of Australia Research Fellow University of Adelaide
    2002 - 2002 NHMRC Senior Research Officer University of Adelaide
    2001 - 2001 NHMRC Senior Research Officer Flinders University
  • Education

    Date Institution name Country Title
    1995 - 1998 University of Adelaide Australia PhD
    1994 - 1994 University of Adelaide Australia BSC (Hons)
    1991 - 1993 University of Adelaide Australia BSc
  • Postgraduate Training

    Date Title Institution Country
    1998 - 2001 Postdoctoral Fellow Memorial Sloan Kettering Cancer Center, New York United States
  • Research Interests

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Principal Supervisor Targeting Lipid Metabolism in Prostate Cancer Master of Philosophy (Medical Science) Master Full Time Miss Deanna Catherine Miller
    2019 Principal Supervisor Androgen Regulation of Lipid Metabolism Doctor of Philosophy Doctorate Full Time Miss Julia Steele Scott
    2019 Co-Supervisor Elucidating the Interplay Between Androgen Receptor Signalling and Lipid Metabolism in Prostate Cancer Doctor of Philosophy Doctorate Full Time Ms Meiwen Danielle Fang
    2018 Principal Supervisor The Establishment of a Pre-clinical Pipeline for Evaluating Stromal Targets in Colorectal Tumourigenesis Doctor of Philosophy Doctorate Full Time Miss Krystyna Anna Gieniec
    2018 Principal Supervisor Androgen-Regulated Drivers of Prostate Tumorigenesis Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Josephine Ataa Hinneh
    2018 Principal Supervisor Targeting Polyunsaturated Fatty Acid Metabolism in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Chui Yan Mah
    2017 Co-Supervisor Interactions between Androgen signalling and the lipid microenvironment in prostate cancer Doctor of Philosophy Doctorate Full Time Mr Raj Kumar Shrestha
    2016 Principal Supervisor Defining the Role of Lipids in Prostate Cancer Doctor of Philosophy Doctorate Full Time Dr Adel Tahseen Abdelhamid Aref
    2016 Principal Supervisor Understanding the Role of Androgen Receptor Signalling in Prostate Cancer: A Lipidomics Approach Doctor of Philosophy Doctorate Full Time Mr Shadrack Mulinge Mutuku
    2016 Co-Supervisor The Role of Meflin in the Mesenchyme Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Mr Hiroki Kobayashi
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2013 - 2016 Co-Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das
    2013 - 2016 Principal Supervisor Elucidating the Molecular Action of Synthetic Heat Shock Protein 90 Inhibitors in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Heather Krista Armstrong
    2008 - 2011 Co-Supervisor Investigating Lymphatic Vascular Remodelling During Postnatal Mouse Mammary Gland Morphogenesis Doctor of Philosophy Doctorate Full Time Ms Kelly Louise Betterman
    2007 - 2015 Principal Supervisor Combinatorial Targeting of the Androgen Receptor for Prostate Cancer Therapy Doctor of Philosophy Doctorate Full Time Miss Sarah Carter
    2006 - 2010 Co-Supervisor The Role of Epigenetic Modifications in Prostate Tumourigenesis Doctor of Philosophy Doctorate Full Time Ms Karen Huiqin Chiam
    2004 - 2008 Co-Supervisor Characterisation of a Dominant Negative Androgen Receptor in Prostate Cancer Cells Doctor of Philosophy Doctorate Part Time Dr Margaret Centenera
    2004 - 2008 Principal Supervisor Androgen Signalling in Normal and Malignant Breast Epithelial Cells Doctor of Philosophy Doctorate Part Time Ms Amelia Peters
    2003 - 2007 Co-Supervisor Targeting the Androgen Receptor as a Therapeutic Strategy for Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Deborah Marrocco
  • Position: Cancer Council Principal Research Fellow
  • Phone: 81284360
  • Email: lisa.butler@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI - Prostate Cancer Research Group, floor 5
  • Org Unit: Medical Specialties

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