Dr Margaret Centenera
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
- My Research
- Grants and Funding
- Professional Activities
Dr Centenera is a Research Fellow in the Prostate Cancer Research Group located at the South Australian Health and Medical Research Institute. Her research is focused on improving treatments for men with prostate cancer. This involves understanding and targeting the androgen receptor in prostate cancer cells, and identifying more accurate markers for monitoring patient response to current and emerging prostate cancer therapeutics. Dr Centenera is an expert in patient-derived explants as a preclinical model of prostate cancer.
Date Position Institution name 2016 - ongoing Research Fellow University of Adelaide 2013 - 2015 Prostate Cancer Foundation of Australia Young Investigator University of Adelaide 2008 - 2012 Postdoctoral Research Officer University of Adelaide 2007 - 2008 Research Associate University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Invitation Markers in Cancer Diagnostic Development Tutorial American Society of Clinical Oncology United States - 2015 Award School of Medicine Travel Grant University of Adelaide Australia - 2013 Award Beat Cancer Project Travel Award South Australia Heart and Medical Research Institute Australia - 2012 Fellowship School of Medicine Travel Grants University of Adelaide Australia - 2010 Award Travel Grant Prostate Cancer Foundation of Australia Australia - 2008 Recognition Letter of Commendation-PhD Thesis Examiner University of Adelaide Australia - 2006 Award School of Molecular and Biomedical Science Postgraduate Conference Travel Award University of Adelaide Australia - 2004 Award Travel Award The Lorne Cancer Conference - - 2004 Scholarship Faculty of Health Sciences PhD Scholarship University of Adelaide Australia - 2003 Scholarship Honours Research Scholarhip The Queen Elizabeth Hospital Australia - 2003 Recognition Best Honours Presentation The Queen Elizabeth Hospital Australia -
Date Institution name Country Title 2004 - 2008 Department of Physiology Australia Doctor of Philosophy 2003 - 2003 Department of Physiology Australia Bachelor of Science with First Class Honours 1997 - 2001 University of Adelaide Australia Bachelor of Health Science
Year Citation 2022 Strach, M. C., Yeung, N., Lin, H. -M., Ansari, N., Koh, C., Shin, J. -S., . . . Mahon, K. (2022). Patient-derived explant model of appendiceal cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 40 (pp. 1 page). LIPPINCOTT WILLIAMS & WILKINS. 2017 Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Butler, L. (2017). Lipid elongation: an unexplored therapeutic target in prostate cancer. In CANCER RESEARCH Vol. 77 (pp. 2 pages). Washington, DC: AMER ASSOC CANCER RESEARCH.
2017 Tran, L. N. K., Kichenadasse, G., Ormsby, R. J., Morel, K. L., Butler, L. M., Centenera, M. M., & Sykes, P. J. (2017). COMBINATION OF METFORMIN AND SODIUM VALPROATE FOR PROSTATE CANCER: A RAPID APPROACH FROM BENCH TO CLINICAL TRIAL.. In JOURNAL OF UROLOGY Vol. 197 (pp. E1108-E1109). Boston, MA: ELSEVIER SCIENCE INC.
2009 Butler, L., Centenera, M., Marrocco, D., Carter, S., Bianco-Miotto, T., & Tilley, W. (2009). A novel combinatorial approach using androgen receptor-targeted agents for treatment of prostate cancer. In Cancer Research Vol. 69 (pp. 2 pages). American Association for Cancer Research.
Year Citation 2020 Butler, L. M., Mah, C. Y., Dehairs, J., Vincent, A., Mutuku, S., Spotbeen, X., . . . Swinnen, J. (2020). Phospholipid profiling of clinical prostate tissues reveals targetable alterations in membrane lipid composition accompanying tumorigenesis. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH.
2020 Mah, C. Y., Nassar, Z. D., Burvenich, I. J., Irani, S., Centenera, M. M., Moldovan, M., . . . Butler, L. M. (2020). DECR1: The rate limiting enzyme of polyunsaturated fatty acid metabolism and a novel therapeutic target in prostate cancer. Poster session presented at the meeting of CANCER RESEARCH. ELECTR NETWORK: AMER ASSOC CANCER RESEARCH.
2019 Scheinberg, T., Kench, J., Stockler, M., Mahon, K. L., Sebastian, L., Stricker, P., . . . Horvath, L. G. (2019). Pharmacodynamics Effects of CDK4/6 Inhibitor LEE011 (Ribociclib) in High-Risk, Localised Prostate Cancer: A Study Protocol for a Randomised Controlled Phase II Trial (Leep Study). Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY. 2019 Butler, L., Irani, S., Centenera, M., Ryan, N., Pegg, N., & Brooks, A. N. (2019). Preclinical investigation of a small molecule inhibitor of p300/CBP reveals efficacy in patient-derived prostate tumor explants.. Poster session presented at the meeting of JOURNAL OF CLINICAL ONCOLOGY. Chicago, IL: AMER SOC CLINICAL ONCOLOGY.
2018 Mutuku, S. M., Centenera, M. M., Trim, P. J., Snel, M. F., & Butler, L. M. (2018). Evaluation of small molecule drug uptake in ex vivo cultured clinical prostate tumours by mass spectrometry. Poster session presented at the meeting of BJU INTERNATIONAL. Brisbane, AUSTRALIA: WILEY. 2018 Nassar, Z. D., Centenera, M. M., Machiels, J., Zinonos, I., Hanson, A., Bloch, K., . . . Swinnen, J. V. (2018). Lipid elongation in prostate cancer is androgen regulated and a potential therapeutic target. Poster session presented at the meeting of BJU International. Brisbane, Australia: Wiley. 2017 Mutuku, S. M., Prabhala Bala., Centenera, M., Trim, P., Snel, M., & Butler, L. (2017). Quantification of Enzalutamide in Cultured Prostate Tissue Using LC-MS/MS. Poster session presented at the meeting of 26th Australian and New Zealand Society for Mass Spectrometry. Flinders University. 2017 Mutuku, S. M., Centenera, M., Trim, P., Gustafsson, O. J., Snel, M., & Butler, L. (2017). A Mass Spectrometry Approach to Characterise Lipid Composition in Prostate Tumuors. Poster session presented at the meeting of 11th Florey Postgraduate Research Conference. Adelaide. 2016 Nassar, Z. D., Centenera, M. M., Machiels, J., Polacek, S. J., Bloch, K., Tilley, W. D., . . . Swinnen, J. V. (2016). Androgenic regulation of lipid elongation in prostate cancer. Poster session presented at the meeting of BJU International. Melbourne: Wiley. 2015 Armstrong, H., Butler, L., Selth, L., Tarulli, G., & Centenera, M. (2015). The Hsp90 inhibitor, NVP-AUY922, produces anti-tumour activity through inhibition of fibronectin polymerization resulting in cytoskeletal reorganization. Poster session presented at the meeting of BJU INTERNATIONAL. Cairns, AUSTRALIA: WILEY-BLACKWELL. 2010 Centenera, M., Treloar, J., Hanson, A., Sutherland, P., Tilley, W., & Butler, L. (2010). Evaluation of the synthetic heat shock protein 90 inhibitors NVP-AUY922 and NVP-HSP990 in human prostate cancer tissue. Poster session presented at the meeting of European Journal of Cancer Supplements. Berlin, Germany: Elsevier.
2018 - 2020
|Novel co-extinction strategies for treatment of prostate cancer||Butler LM, Lynn DJ, Hayes VM, Horvath LG, Mills IG, Centenera MM||Cancer Australia||$596,409|
|2015 - 2017||Exploiting alterations in lipid metabolism to improve diagnosis, treatment and molecular imaging of prostate cancer||
Butler LM, Swinnen JV, Tilley WD, Scott AM, Hoy AJ and Wittert GA
Co-Leads: Centenera MM, Selth LA, Dhomen N, Soekmadji C
|Movember Foundation / Prostate Cancer Foundation of Australia (MRTA3||$3,250,000|
|2015 - 2017||Molecular hallmarks of heat shock protein 90 inhibition in prostate cancer||Butler LM, Daly R, Tilley WD, Horvath LG, Centenera MM||Cancer Australia (APP1085471)||$553,483|
|2013 - 2015||Explant technology for biomarker discovery of androgen receptor targeted therapies||
|Prostate Cancer Foundation of Australia Young Investigator Grant (YIG0412)||$450,000|
|2013||Evaluation of biomarkers of response to Hsp90 inhibition in human prostate cancer||Centenera MM and Butler LM||Royal Adelaide Hospital Clinical Project Grant||$40,000|
|2012 - 2014||Exploiting metabolic alterations to more accurately monitor prostate cancer therapy||Butler LM, Centenera MM, Claessens F, Swinnen J||Prostate Cancer Foundation of Australia New Directions Development Award (NDDA 2711)||
|2011||Identification of biomarkers of response to Hsp90 inhibition in human prostate cancer.||Centenera MM, Butler LM and Tilley WD.||Royal Adelaide Hospital Clinical Project Grant||$25,000|
Alyssa Fitzpatrick (co-supervisor), Summer Scholarship (2010), MBBS Year 4&5 Research component (2010-11), University of Adelaide
Undergraduate student co-supervision of laboratory-based research projects
Sean Burton (2007) Physiology III, Bachelor of Science, University of Adelaide
MJ Vink, BJ Rositano, EF Jackson (2011) Structural Cell Biol III, Bachelor of Science, University of Adelaide
Shinjie Wong (2013) Summer Scholarship, University of Adelaide
Roseanna Hunter (2014) Summer Scholarship, Freemasons Foundation Centre for Men’s Health, University of Adelaide
K Bremert, C Webber, L Day (2015) Investigative Cell Biol II, Bachelor of Science, University of Adelaide
Kayla Bremert (2016) Summer Scholarship, University of Adelaide
Teaching & assessment
Practical supervisor/tutor/assessor (2004) University of Adelaide, Bachelor of Science, Biology I
Practical supervisor/tutor/assessor (2005) University of Adelaide, Bachelor of Science, Physiology III
Examiner Honours students (2007-10) University of Adelaide, Department of Obstetrics and Gynaecology
Poster award judge (2009-11) The Australian Society for Medical Research, South Australian Meeting
Guest lecturer (2016-current) University of Adelaide, School of Medicine, Integrative Cell Biology – 1 lecture/year
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Principal Supervisor Overcoming resistance to cyclin-dependent kinase inhibition in prostate cancer Doctor of Philosophy Doctorate Full Time Mr Joshua Thomas Hodgson 2020 Principal Supervisor Targeting Lipid Metabolism in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Deanna Catherine Miller 2018 Co-Supervisor Androgen-Regulated Drivers of Prostate Tumorigenesis Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Josephine Ataa Hinneh
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2013 - 2016 Co-Supervisor Elucidating the Molecular Action of Synthetic Heat Shock Protein 90 Inhibitors in Prostate Cancer Doctor of Philosophy Doctorate Full Time Miss Heather Krista Armstrong
Date Role Committee Institution Country 2016 - ongoing Member School of Medicine Early/Mid-Career Research Committee University of Adelaide Australia 2015 - ongoing Member Faculty of Health Sciences Low Risk Human Research Ethics Committee University of Adelaide Australia
Connect With Me