John Horowitz

Professor John Horowitz

Head of Cardiology

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


Professor John Horowitz is a Professor of Cardiology at the University of Adelaide, and Director of Cardiology and Clinical Pharmacology at The Queen Elizabeth Hospital (TQEH). He completed his undergraduate studies in Adelaide, and his postgraduate training in Melbourne and Boston, taking up his current position in 1988.

Project 1. Coronary artery spasm

The research group has recently found that coronary artery spasm, a common cause of cardiac crises, is due to interactions between activated platelets and the vascular surface of the coronary blood vessels, with poor vascular and platelet responsiveness to nitric oxide. We have preliminary data on the underlying mechanisms whereby coronary spasm presents with episodic crises, and wish to validate these pilot data, simultaneously turning the information into the bases for new therapeutic options for these patients, and also possibly for other patients with angina.

 Available for Honours, Masters and PhD students

Location: QEH/BHI.

Start: Semester 1 2020

Special requirements: Vaccination required

 

Project 2 : Preventing heart damage during cancer chemotherapy

   The improved results for cancer chemotherapy come at the price of an increased risk of late heart failure. The project will evaluate means of protecting the heart during chemotherapy, by identifying the chemical cause of the damage and neutralising its effects on the heart.

 Available for Honours, Masters and PhD students

Location: QEH/BHI.

Start: Semester 1 2020

Special requirements: Vaccination required

 

Project 3: Maximising protective effects of BNP in patients with heart failure

 B-type natriuretic peptide (BNP) is theoretically cardioprotective, bu paradoxically does not work in patients with heart failure. We have identified the cause of this problem, and now wish to develop therapeutic strategies to improve BNP responses, not only in patients with isolated heart failure, but also in those with heart failure secondary to influenza virus infection.

 Available for Honours, Masters and PhD students

Location: QEH/BHI.

Start: Semester 1 2020

Special requirements: Vaccination required

 

Project 4:  Variability of anti-aggregatory effects of P2Y12 receptor antagonists: therapeutic adjustments

  Clopidogrel and ticagrelor are antagonists at the P2Y12 receptor, which limit platlet aggregation: they are used mainly to prevent thrombosis of coronary stents. However, responses vary substantially. We intend to develop regimens for individual patients who, on theoretical grounds, are at risk for either bleeding or thrombosis when placed on theoretically "standard" treatment regimens.

 Available for Honours, Masters and PhD students

Location: QEH/BHI.

Start: Semester 1 2020

Special requirements: Vaccination required

 

Project 5:  Improving outcomes after takotsubo (broken heart) syndrome

 Takotsubo syndrome (TTS) affects many ageing patients, especially women, and is often mistaken for heart attacks. We are trying to improve diagnosis, emergency and long-term treatment of TTS, using both clinical and basic investigation strategies.

Available for Honours, Masters and PhD students

Location: QEH/BHI.

Start: Semester 1 2020

Special requirements: Vaccination required

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 Principal Supervisor Receptor and Postreceptor Determinants of Platelet Responses to Ticagrelor Doctor of Philosophy Doctorate Part Time Mr Gao Jing Ong
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 - 2018 Principal Supervisor Inter-Individual Variability in Platelet Adenylate and Soluble Guanylate Cyclase Signaling: Therapeutic Perspectives Doctor of Philosophy Doctorate Full Time Mr Md Hasan Imam
    2014 - 2016 Principal Supervisor Endothelial Dysfunction and Inflammatory Activation in Patients with Bicuspid Aortic Valves Master of Clinical Science Master Part Time Mr Matthew John Chapman
    2014 - 2019 Principal Supervisor Nitrosative Stress and the Pathogenesis of Takotsubo Syndrome: Insights from a Novel Female Rat Model Doctor of Philosophy Doctorate Full Time Sven Yuri Surikow
    2014 - 2018 Principal Supervisor Interactions between Cardiac Resynchronisation Therapy and Amelioration of Peripheral Vascular Dysfunction: Impact upon Outcomes Doctor of Philosophy Doctorate Full Time Dr Chukwudiebube Nnanna Ajaero
    2012 - 2017 Co-Supervisor A Pharmacological Approach Towards Myocardial Protection: New Perspectives in Acute and Chronic Cardiac Disease Doctor of Philosophy Doctorate Full Time Miss Cher-Rin Chong
    2012 - 2015 Principal Supervisor Natural History and Pathogenesis of Takotsubo Cardiomyopathy Doctor of Philosophy Doctorate Full Time Dr Kuljit Singh
    2011 - 2015 Principal Supervisor Effects of Nitrite and Nitroxyl on Human Vascular and Platelet Function Doctor of Philosophy Doctorate Full Time Dr Rustem Dautov
    2010 - 2015 Principal Supervisor Variability of Nitric Oxide Signalling in Atrial Fibrillation: Potential Modulation Doctor of Philosophy Doctorate Part Time Mr Nathan Edward Kevin Procter
    2010 - 2015 Principal Supervisor Impaired Tissue Responsiveness to B-Type Natriuretic Peptide in Heart Failure: Biochemical Bases Doctor of Philosophy Doctorate Full Time Dr Saifei Liu
    2009 - 2014 Principal Supervisor Tako-Tsubo (Stress) Cardiomyopathy: Pathophysiology and Natural History Doctor of Philosophy Doctorate Full Time Dr Christopher Neil
    2009 - 2016 Principal Supervisor Post-P2Y 12-Receptor Signalling Mechanisms and Platelet Responses to Clopidogrel Doctor of Philosophy Doctorate Full Time Dr Nicola Hurst
    2008 - 2012 Principal Supervisor The Role of Oxidant Stress in a Cellular Model of Aortic Valve Cell Calcification Master of Medical Science Master Part Time Dr Navin S Kanagasingam
    2008 - 2012 Co-Supervisor Implications of Catecholamine-related Pathophysiology in Cardiomyopathy Doctor of Philosophy Doctorate Full Time Dr Thanh Ha Nguyen
    2006 - 2013 Principal Supervisor Cardiovascular Risk Assessment in Women: Impact of Ageing, Polycystic Ovarian Syndrome and Menopause on Nitric Oxide Signalling Doctor of Philosophy Doctorate Full Time Dr Alicia Chan
    2006 - 2016 Principal Supervisor Mechanisms of dyspnoea and poor exercise tolerance in a representative cohort of elderly patients with a relatively normal ejection fraction on echocardiography Doctor of Philosophy Doctorate Full Time Dr Gnanadevan Mahadevan
    2005 - 2009 Principal Supervisor Platelet and Endothelial Function: Polycystic Ovary Syndrome and the Renin-Angiotensin System Doctor of Philosophy Doctorate Full Time Dr Sharmalar Rajendran
    2005 - 2012 Principal Supervisor Pathogenesis of Aortic Stenosis: Implications Regarding Impairment of Nitric Oxide Signalling Doctor of Philosophy Doctorate Full Time Dr Aaron Sverdlov
    2004 - 2007 Co-Supervisor Induction of Myocardial Ischaemia: A Comparison of Pharmacologic and Physiologic Stress Myocardial Perfusion Imaging Master of Medical Science Master Full Time Dr Thanh Ha Nguyen
    2004 - 2008 Principal Supervisor Potential Utility of Changes in Entropy as an Adjunct to the Electrocardiography Diagnosis of Reversible Myocardial Ischaemia Master of Medical Science Master Full Time Dr Jinlin Zhao
    2003 - 2007 Principal Supervisor Pathogenesis of Aortic Valve Stenosis: Bench to Bedside Approach Doctor of Philosophy Doctorate Full Time APrf Doan Ngo
    2003 - 2007 Principal Supervisor Effect of Nitric Oxide on Aortic Valve Calcification in vitro Master of Clinical Science Master Full Time Mr Xiang Hua
    2002 - 2007 Co-Supervisor Vasomotor and Anti-Oxidant Effects of Anti-Ischaemic Therapies. Doctor of Philosophy Doctorate Full Time Miss Elizabeth Liberts
    2000 - 2005 Co-Supervisor TISSUE RESPONSES TO NITRIC OXIDE DONORS: STUDIES IN PLATELETS AND IN MYOCARDIUM Doctor of Philosophy Doctorate Full Time APrf Matthew Worthley
    1998 - 2003 Principal Supervisor Pathophysiological and platelet anti-aggregatory effects of nitric oxide Doctor of Philosophy Doctorate Full Time Dr Andrew Holmes
    1998 - 2002 Principal Supervisor Tolerance and Resistance to Organic Nitrates in Human Blood Vessels Doctor of Philosophy Doctorate Full Time Mr Peter Sage
  • Position: Head of Cardiology
  • Phone: 82226342
  • Email: john.horowitz@adelaide.edu.au
  • Fax: 8222 6422
  • Campus: The Queen Elizabeth Hospital
  • Building: QEH - Main Bldg, floor 3
  • Room: 3 D
  • Org Unit: Medicine

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