Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
With a background of Medicine (Hebei Medical University, China), Medical Biotechnology (Masters, Flinders University) and Medical Science (PhD, University of Adelaide), I am a basic and translational cardiovascular researcher, undertaking a wide range of clinical and basic science research projects.
My current research relates to three areas:- (i) Chemotherapy induced cardiotoxicity, (ii) B-type natriuretic peptide physiology and pathophysiology in heart failure, and (iii) Mechanistic interactions of inflammatory activation and glycocalyx shedding in cardiovascular disease.
Topic 1: Chemotherapy induced cardiotoxicity
Cancer now affects more than 1 in 3 people in their lifetime and along with cardiovascular disease, they are the two leading causes of death. Cancer outcomes contribute to improve due to earlier detection and newer targeted therapies, with chemotherapy and immunotherapy playing prominent roles in treating many forms of cancer. Recently, substantial improvements in outcomes among patients treated for most cancers have been recorded, but virtually all the agents utilized can cause permanent and potentially fatal heart damage (cardiotoxicity). If this process is left unchecked, it can sometimes cause severe heart failure. Although this is rare (under 1 in 20 patients), heart failure is a serious illness that can be difficult to treat, with a high mortality rate. At this stage, the exact mechanism of drug-induced cardiotoxicity remains unclear.
We are currently running a clinical trial recruiting cancer patients attending QEH Oncology clinics and receiving chemotherapy to study the potential usefulness of certain biomarkers to early identify patients at risk of developing heart failure and help us guide future treatment. We have also established a cell-culture model of anthracycline-induced cardiotoxicity in human cardiac myocytes and aim to use this to evaluate (1) the mechanisms associated with damage to the heart cells and (2) potential cardio protective treatment options.
We are also planning to start setting up a clinical Cardio-Oncology Registry, to evaluate tumor-related and cardiovascular outcomes in all patients considered for cancer chemo- or immuno-therapy.
Topic 2: Impaired BNP anti-inflammatory effects in acute heart failure: interactions with viral infections and pharmacotherapy.
Acute heart failure (AHF) represents a very common cause of admission to hospitals and indeed to
intensive care units. With a progressive increase in numbers of patients in the community with chronic
heart failure, this is an increasingly important problem.
B-type natriuretic peptide (BNP) is a hormone released from the heart which releases blood vessels and
helps to resolve inflammation: the latter is a major feature of AHF. I have previously shown that in
patients with AHF, the anti-inflammatory effects of BNP are defective, but that they recover over the
next few weeks as patients are treated.
Very recently, researchers (mainly in Melbourne) have shown that the influenza virus induces, and
thrives in, and environment of high levels of inflammation. Thus would help to explain why influenza
often causes AHF, but no specific treatment is available.
We propose to study patients admitted to hospital with AHF with/without viral infections, and:-
(1) determine whether impairment of BNP response is particularly marked in the presence of viral
(2) identify optimal strategies for rapid restoration of BNP response.
The results should assist in the management of patients with AHF
Date Position Institution name 2017 - 2018 Postdoctoral Fellow University of Adelaide, Adelaide 2015 - 2016 Technical Officer The Queen Elizabeth Hospital
Language Competency Chinese (Mandarin) Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2011 - 2015 University of Adelaide, Adelaide Australia PhD 2008 - 2009 Flinders University, Adelaide Australia Masters
Year Citation 2019 Liu, S., & Horowitz, J. (2019). N-ACETYLCYSTEINE REVERSES PEROXYNITRITE AND HYDROGEN PEROXIDE-INDUCED APOPTOSIS OF HUMAN MYOCARDIAL CELLS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 73 (pp. 1022). New Orleans, LA: ELSEVIER SCIENCE INC.
2017 Procter, N., Pasupathy, S., Stafford, I., Heresztyn, T., Liu, S., Selvanayagam, J., . . . Horowitz, J. (2017). Glycocalyx shedding in acute myocardial infarction: interactions with reperfusion and n-acetylcysteine therapy. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 1189-1190). OXFORD UNIV PRESS. 2017 Nguyen, T. H., Stansborough, J., Ong, G. J., Surikow, S., Frenneaux, M. P., & Horowitz, J. D. (2017). Implications of "Secondary" Takotsubo Syndrome on Short and Longterm Event Rates. In CIRCULATION Vol. 136 (pp. 2 pages). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS. 2016 Ding, Z., Liu, S., & Mehta, J. L. (2016). mtDNA Damage in Concert With PCSK9 Expression Induces Apoptosis in Vascular Smooth Muscle Cells. In CIRCULATION Vol. 134 (pp. 2 pages). New Orleans, LA: LIPPINCOTT WILLIAMS & WILKINS.
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