
Dr Cher-Rin Chong
NHMRC Ext-Funded Rsch Fellow B
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Welcome to my homepage. I am a translational researcher, with significant experience in community and hospital clinical pharmacy in Australia. My PhD was in cardiovascular pharmacology, and my immediate postdoctoral training was in physiological biochemistry and cardiac metabolism. I returned to Adelaide in late 2019 to set up my own research program.
My research interests lie primarily in understanding the metabolic regulation of the heart, and how the process of energy generation in the heart affects cardiac function. My research adopts a translational "bench-to-bedside" approach. I am particularly keen in applying the knowledge gained towards developing targeted therapeutics and improving health outcomes.
Key research areas:
- Cardiac metabolism, pharmacology & physiology
- Ketone metabolism
- Obesity, diabetes and diabetic heart
- Takotsubo (stress) syndrome
Research techniques used in my lab include:
- Vascular organ bath
- Langendorff and working heart perfusions, with additional capacity to pace and perform radiolabelled measurements
- Platelet aggregometry
- Ultrasound preclinical imaging
- Applanation tonometry
- High-performance liquid chromatography, immunoblotting/immunohistochemistry, qPCR
- Primary and non-primary cell cultures
- Evidence synthesis through meta-analysis and systematic review
Joining the lab:
I am always on the lookout for enthusiastic, curious and motivated students or postdocs to join the lab. Recruitment for research degree graduates (honour's, Master's and PhD), as well as scholarship application, will be conducted via the University's programs. For postdoctoral researcher, I will provide support for application to fellowship programs. If you are interested, please reach out to me at cher-rin.chong@adelaide.edu.au to discuss potential project and application, along with a copy of your CV.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
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Appointments
Date Position Institution name 2019 - ongoing NHMRC Peter Doherty & Heart Foundation Research Fellow University of Adelaide 2016 - 2019 Nuffield Medical Fellow University of Oxford 2012 - 2016 NHMRC Dora Lush PhD candidate University of Adelaide 2008 - 2016 Rotating pharmacist, Pharmacist registrar, Senior pharmacist The Queen Elizabeth Hospital, SA Department of Health 2007 - 2007 Intern pharmacist Community pharmacies -
Language Competencies
Language Competency Chinese (Cantonese) Can read, write, speak and peer review Chinese (Mandarin) Can read, write, speak and peer review English Can read, write, speak and peer review Malay Can read, write and speak -
Education
Date Institution name Country Title University of Adelaide Australia Ph.D. University of South Australia Australia Bachelor of Pharmacy -
Research Interests
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Journals
Year Citation 2023 Kadir, A. A., Stubbs, B. J., Chong, C. R., Lee, H., Cole, M., Carr, C., . . . Clarke, K. (2023). On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart. Journal of Physiology, 601(7), 1207-1224.
Scopus4 WoS4 Europe PMC22022 Chong, C. -R., Liu, S., Imam, H., Heresztyn, T., Sallustio, B. C., Chirkov, Y. Y., & Horowitz, J. D. (2022). Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling. Biomedicines, 10(10), 2381-1-2381-10.
2021 Ong, G. J., Nguyen, T. H., Kucia, A., Liu, S. -F., Surikow, S. Y., Girolamo, O., . . . Horowitz, J. D. (2021). Takotsubo syndrome: Finally emerging from the shadows?. Heart Lung and Circulation, 30(1), 36-44.
Scopus9 WoS9 Europe PMC32021 Yurista, S. R., Chong, C. -R., Badimon, J. J., Kelly, D. P., de Boer, R. A., & Westenbrink, B. D. (2021). Therapeutic potential of ketone bodies for patients with cardiovascular disease: JACC focus seminar. Journal of the American College of Cardiology, 77(13), 1660-1669.
Scopus90 WoS79 Europe PMC542021 Chong, C. -R., Liu, S., Imam, H., Heresztyn, T., Sallustio, B., Chirkov, Y. Y., & Horowitz, J. D. (2021). Perhexiline Therapy in Patients with Type 2 Diabetes: Dissociation Between Potentiation of Nitric Oxide Signalling and Changes in Insulin Resistance.
2020 Horowitz, J. D., & Chong, C. -R. (2020). Matrix metalloproteinase-2 activation: critical to myocardial contractile dysfunction following ischaemia-reperfusion.. Cardiovascular research, 116(5), 876-878.
Scopus3 WoS3 Europe PMC32020 Liu, S., Ngo, D., Chirkov, Y., Stansborough, J., Chong, C., & Horowitz, J. D. (2020). Prolonged suppression of the anti-oxidant/anti-inflammatory effects of BNP post-Takotsubo syndrome. ESC Heart Failure, 7(5), 2250-2257.
Scopus1 Europe PMC12019 Roberts, G., Chong, C. R., Quinn, S., Cameron-Collins, S., Forbes, H., Johnson, J. L., . . . Wisdom, A. (2019). Evaluation of the effect of direct oral anticoagulant availability on hospital presentations for bleeding related to oral anticoagulation in South Australia. Journal of Pharmacy Practice and Research, 49(6), 517-524.
2019 Drury, N. E., Yim, I., Patel, A. J., Oswald, N. K., Chong, C. -R., Stickley, J., & Jones, T. J. (2019). Cardioplegia in paediatric cardiac surgery: a systematic review of randomized controlled trials. Interactive CardioVascular and Thoracic Surgery, 28(1), 144-150.
Scopus14 WoS11 Europe PMC92019 Imam, H., Nguyen, T. H., De Caterina, R., Nooney, V. B., Chong, C. R., Horowitz, J. D., & Chirkov, Y. Y. (2019). Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y<inf>12</inf> receptor antagonists. Thrombosis Research, 181, 92-98.
Scopus6 WoS4 Europe PMC22018 Timm, K. N., Apps, A., Miller, J. J., Ball, V., Chong, C. R., Dodd, M. S., & Tyler, D. J. (2018). Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS. NMR in Biomedicine, 31(9), e3992.
Scopus1 WoS1 Europe PMC12018 Ajaero, C., Chong, C. -R., Procter, N., Liu, S., Chirkov, Y., Heresztyn, T., . . . Horowitz, J. (2018). Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?. ESC heart failure, 5(1), 129-138.
Scopus1 WoS1 Europe PMC22018 Drury, N. E., Patel, A. J., Oswald, N. K., Chong, C. -R., Stickley, J., Barron, D. J., & Jones, T. J. (2018). Randomized controlled trials in children’s heart surgery in the 21st century: a systematic review. European Journal of Cardio-Thoracic Surgery, 53(4), 724-731.
Scopus13 WoS14 Europe PMC122017 Chong, C. -R., Clarke, K., & Levelt, E. (2017). Metabolic remodelling in diabetic cardiomyopathy. Cardiovascular Research, 113(4), 422-430.
Scopus103 WoS89 Europe PMC592016 Chong, C., Sallustio, B., & Horowitz, J. (2016). Drugs that Affect Cardiac Metabolism: focus on Perhexiline. Cardiovascular Drugs and Therapy, 30(4), 399-405.
Scopus22 WoS19 Europe PMC122016 Chong, C., Ong, G., & Horowitz, J. (2016). Emerging drugs for the treatment of angina pectoris. Expert Opinion on Emerging Drugs, 21(4), 365-376.
Scopus10 WoS9 Europe PMC52016 Phuong, H., Choi, B., Chong, C., Raman, B., & Horowitz, J. (2016). Can perhexiline be utilized without long-term toxicity? A clinical practice audit. Therapeutic Drug Monitoring, 38(1), 73-78.
Scopus13 WoS11 Europe PMC42015 Procter, N. E., Ball, J., Heresztyn, T., Nooney, V. B., Liu, S., Chong, C. -R., . . . Horowitz, J. D. (2015). Subtle renal dysfunction and bleeding risk in atrial fibrillation: symmetric dimethylarginine predicts HAS-BLED score.. American journal of cardiovascular disease, 5(2), 101-109.
WoS12015 Chong, C., Drury, N., Licari, G., Frenneaux, M., Horowitz, J., Pagano, D., & Sallustio, B. (2015). Stereoselective handling of perhexiline: implications regarding accumulation within the human myocardium. European Journal of Clinical Pharmacology, 71(12), 1485-1491.
Scopus11 WoS9 Europe PMC62015 Horowitz, J., Chong, C., Ngo, D., & Sverdlov, A. (2015). Effects of acute hyperglycaemia on cardiovascular homeostasis: Does a spoonful of sugar make the flow-mediated dilatation go down?. Journal of Thoracic Disease, 7(12), 607-611.
Scopus4 WoS3 Europe PMC32015 Chong, C., Liu, S., Licari, G., Heresztyn, T., Chirkov, Y., Ngo, D., & Horowitz, J. (2015). Reversal of hyperglycemia: effects on nitric oxide signaling. American Journal of Medicine, 128(4), 427-430.
Scopus6 WoS6 Europe PMC52015 Singh, K., Chong, C. R., Nguyen, T. H., Stansborough, J., & Horowitz, J. D. (2015). Reply: Takotsubo syndrome is a systemic, rather than merely a cardiac, disease: Possible effects on the systemic and pulmonary vasculature. Heart Lung and Circulation, 24(4), 417-418.
2015 Liu, S., Ngo, D., Chong, C., Amarasekera, A., Procter, N., Licari, G., . . . Horowitz, J. (2015). Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for 'BNP resistance'. European Journal of Heart Failure, 17(5), 475-483.
Scopus10 WoS9 Europe PMC82015 Angus, D., Barnato, A., Bell, D., Bellomo, R., Chong, C., Coats, T., . . . Young, J. (2015). A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Medicine, 41(9), 1549-1560.
Scopus279 WoS248 Europe PMC1822014 Procter, N., Chong, C., Sverdlov, A., Chan, W., Chirkov, Y., & Horowitz, J. (2014). Aging of platelet nitric oxide signaling: pathogenesis, clinical implications, and therapeutics. Seminars in Thrombosis and Hemostasis, 40(6), 660-668.
Scopus13 WoS11 Europe PMC72014 Chong, C., Chan, W., Nguyen, T., Liu, S., Procter, N., Ngo, D., . . . Horowitz, J. (2014). Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. Cardiovascular Drugs and Therapy, 28(4), 347-360.
Scopus69 WoS67 Europe PMC492014 Drury, N., Licari, G., Chong, C., Howell, N., Frenneaux, M., Horowitz, J., . . . Sallustio, B. (2014). Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake. British Journal of Clinical Pharmacology, 77(5), 789-795.
Scopus9 WoS9 Europe PMC82014 Singh, K., Neil, C., Nguyen, T., Stansborough, J., Chong, C., Dawson, D., . . . Horowitz, J. (2014). Dissociation of early shock in Takotsubo cardiomyopathy from either right or left ventricular systolic dysfunction. Heart, Lung and Circulation, 23(12), 1141-1148.
Scopus23 WoS22 Europe PMC142013 Chong, C. R., Neil, C. J., Nguyen, T. H., Singh, K., & Horowitz, J. D. (2013). Reply. Clinical Cardiology, 36(10), E33.
2013 Chong, C. R., & Horowitz, J. D. (2013). Letters to the editor. Clinical Cardiology, 36(8), 492-493.
2013 Chong, C., Neil, C., Nguyen, T., Stansborough, J., Law, G., Singh, K., & Horowitz, J. (2013). Dissociation between severity of takotsubo cardiomyopathy and presentation with shock or hypotension. Clinical Cardiology, 36(7), 401-406.
Scopus43 WoS39 Europe PMC312012 Neil, C., Chong, C., Nguyen, T., & Horowitz, J. (2012). Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors. Heart, Lung & Circulation (Print Edition), 21(4), 203-205.
Scopus40 WoS35 Europe PMC232012 Neil, C., Nguyen, T., Sverdlov, A., Chirkov, Y., Chong, C., Stansborough, J., . . . Horowitz, J. (2012). Can we make sense of takotsubo cardiomyopathy? An update on pathogenesis, diagnosis and natural history. Expert Review of Cardiovascular Therapy, 10(2), 215-221.
Scopus20 WoS14 Europe PMC13 -
Conference Papers
Year Citation 2015 Chong, C. -R., Stansbourough, J., Raman, B., Nguyen, T. H., Neil, C. J., & Horowitz, J. D. (2015). Determinants of shock and mortality in Takotsubo cardiomyopathy: a cohort study. In EUROPEAN HEART JOURNAL Vol. 36 (pp. 1177-1178). London, ENGLAND: OXFORD UNIV PRESS. -
Conference Items
2023 CIA, Seed funding, Foundation for high blood pressure research
2022 CIA, BHI/THRF equipment grant
2020 CIA, Project grant, Diabetes SA
2019 CIA, Postdoctoral Fellowship, Heart Foundation of Australia (co-funded with NHMRC)
2019 CIA, Peter Doherty Fellowship, NHMRC
2019 CIA, Early Career Fellowship, THRF
2018 CIA, Pump priming grant, Oxford BHF CRE (UK).
2016, CIA, Nuffield Medical Fellowship, University of Oxford (UK)
2014, CIA, Dora Lush Biomedical Research Postgraduate Scholarship, NHMRC
2014, Affiliate Clinical Development Award, CSANZ
2013, 2014 Travelling fellowship, Cardiac Society of Australia and New Zealand (CSANZ)
2013 CIA, Professional development grant, Young Professional Group, SA Department of Health
2011 - 13 Student travel grant, Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists
2005 Student Vacation Scholarship, The Cancer Council Australia
Cher-Rin is involved in the supervision of research placements for third year biomedical students.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Investigating cardiovascular complications of diabetes Doctor of Philosophy Doctorate Full Time Mr Getandale Zeleke Negera -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2020 - 2020 Principal Supervisor Novel treatment to prevent cardiovascular disease in Type 2 diabetes The University of Adelaide - Honours - Emily Kovacev
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Committee Memberships
Date Role Committee Institution Country 2023 - ongoing Member Policy Committee Basil Hetzel Institute for Translational Health Research Australia 2022 - ongoing Member Research advisory committee Diabetes SA Australia 2021 - ongoing Member Emerging Leaders Committee Australian Cardiovascular Alliance Australia 2020 - ongoing Member Management Committee Basil Hetzel Institute for Translational Health Research Australia 2020 - 2020 Member Bliss Adelaide Bliss Australia -
Editorial Boards
Date Role Editorial Board Name Institution Country 2020 - ongoing Member Cardiovascular Drugs and Therapy - United States -
Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2021 - ongoing Project grant Grant Assessment Diabetes UK United Kingdom 2020 - ongoing Project grant Grant Assessment The Netherlands Organisation for Health Research & Development Netherlands 2020 - 2021 Postgraduate scholarship; Project grant Grant Assessment Heart Foundation Australia 2019 - ongoing Project grant Grant Assessment Health Research Council New Zealand 2015 - ongoing Investigator grant; Development grant; Project grant Grant Assessment NHMRC Australia
Connect With Me
External Profiles