School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Dan Peet's research interests are centred on understanding the molecular events within cells that underpin the genomic response to hypoxia. The cellular response to hypoxia is essential for many physiological processes in normal development and adult physiology, and contributes to the pathophysiology of major human diseases, including cancer, myocardial and cerebral ischaemia, pulmonary hypertension, and wound healing. The key components of this cellular response to hypoxia are a unique family of hydroxylase enzymes that act as the primary oxygen sensors, the Hypoxic Inducible transcription Factors (HIFs) that directly regulate gene expression, and specific target genes that mediate cellular changes. His research interests extend beyond the HIFs, to the identification and characterisation of novel substrates of the oxygen-sensing hydroxylases. Understanding these processes has major implications for the diagnosis, prognosis and novel therapeutic approaches to treat human disease.
A more recent focus is on cellular metabolism, specifically the unusual metabolism displayed by proliferating cells, especially cancer cells, that mimic quiescent cells in hypoxia. Of particular interest are the photoreceptor cells in the retina, which also display cancer-like metabolism. A key aim is to determine what controls this unusual metabolism, and whether it is a similar mechanism of control to cancer cells, with important implications for retinal disease.
Year Citation 2008 Zannettino, A., Martin, S. K., Gronthos, S., To, L., & Peet, D. (2008). The role of CXCL12 in multiple myeloma. In F. columbus (Ed.), Cancer Research Progress. Nova Science Publishers. 2007 Hampton-Smith, R., & Peet, D. (2007). Hypoxia Inducible Factor. In T. Staff (Ed.), McGraw-Hill Yearbook of Science & Technology 2007 (pp. 108-111). United States: McGraw-Hill. 2006 Peet, D., & Karttunen, S. (2006). Regulation of HIF: asparaginyl hydroxylation. In D. Chadwick, & J. Goode (Eds.), Signalling pathways in acute oxygen sensing (Vol. 272, pp. 37-51). The Atrium, Southern Gate, Chichester PO19 8SQ, UK: Wiley.
DOI Scopus39 Europe PMC23
Year Citation 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. W. (2017). HIF-2α Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. 2015 Scholz, C., Rodriguez, J., Von Kriegsheim, A., Fabrizio, J., Pickel, C., Cavadas, M., . . . Taylor, C. (2015). FIH regulates cellular metabolism through hydroxylation of the deubiquitinating enzyme OTUB1. In ACTA PHYSIOLOGICA Vol. 213 (pp. 54). WILEY-BLACKWELL. 2006 Duchen, M., Semenza, G., Ratcliffe, P., López-Barneo, J., Prabhakar, N., Acker, H., . . . Archer, S. (2006). Discussion. In Novartis Foundation Symposium Vol. 272 (pp. 8-14). 2006 Ratcliffe, P., Peet, D., Chandel, N., Semenza, G., Stolze, I., Pouysségur, J., . . . Schumacker, P. (2006). Discussion. In Novartis Foundation Symposium Vol. 272 (pp. 49-53). 2006 Murphy, M. P., Schumacker, P. T., Kummer, W., Archer, S. L., Harris, A. L., Sylvester, J. T., . . . Peet, D. (2006). Discussion. In Novartis Foundation Symposium Vol. 272 (pp. 192-195). 2005 Peet, D. J. (2005). Cellular response to hypoxia: A key role for oxygen-sensing peptidyl hydroxylases. In JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Vol. 39 (pp. 568-569). Perth, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. 1999 Rivett, D. E., & Peet, D. J. (1999). Fatty acids chemically bound to protein forms the hydrophic membrane of the hair cuticle. In Experimental Dermatology Vol. 8 (pp. 360-361). Denmark.
Year Citation 2016 Scholz, C. C., Rodriguez, J., Pickel, C., Burr, S., Fabrizio, J. -A., Nolan, K. A., . . . Taylor, C. T. (2016). FIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1. Poster session presented at the meeting of ACTA PHYSIOLOGICA. WILEY-BLACKWELL. 2009 Lisy, K., & Peet, D. J. (2009). Is FIH-1 Phosphorylated? 2-DE Analysis of FIH-1 Isoforms. Poster session presented at the meeting of Hypoxia and Consequences: From Molecule to Malady. New York, New York. 2007 Lisy, K., & Peet, D. J. (2007). Regulation of Gene Expression via the Asparaginyl Hydroxylase Factor Inhibiting HIF (FIH-1). Poster session presented at the meeting of Lorne Cancer Conference. Lorne, Australia. 2006 Lisy, K., & Peet, D. J. (2006). Characterising Expression of the Asparaginyl Hydroxylase Factor Inhibiting HIF (FIH-1). Poster session presented at the meeting of Lorne Genome Conference. Lorne, Australia. 2005 Lisy, K., & Peet, D. J. (2005). Characterisation of FIH-1 Expression. Poster session presented at the meeting of Australian Society for Biochemistry and Molecular Biology ComBio Conference. Adelaide, Australia.
Year Citation 2019 Chey, Y. C. (2019). Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells. (Master's Thesis).
Year Citation 2023 Allen, T. P., Roennfeldt, A. E., Reckdharajkumar, M., Liu, M., Quinn, R. J., Russell, D. L., . . . Bersten, D. C. (2023). dFLASH; dual FLuorescent transcription factor Activity Sensor for Histone integrated live-cell reporting and high-content screening.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Developing cell-based screening systems to identify small molecule inhibitors of the hypoxic signalling protein FIH, and to investigate the signalling pathways of ovulation. Doctor of Philosophy Doctorate Full Time Miss Alison Elizabeth Roennfeldt 2021 Principal Supervisor Investigating the cellular metabolism of the mammalian retina. Doctor of Philosophy Doctorate Full Time Mr David Sean Hansman 2021 Co-Supervisor The Impact of Hypoxia on Flavivirus Infection and Innate Immune Responses Doctor of Philosophy Doctorate Full Time Miss Brooke Nyree Trowbridge 2019 Co-Supervisor Structural Mechanisms of Estrogen Receptor Allostery and Endocrine Disruption Doctor of Philosophy Doctorate Full Time Mr Daniel Patrick McDougal 2019 Co-Supervisor Structure and function of basic-helix-loop-helix transcription factors Doctor of Philosophy Doctorate Full Time Mr Timothy Patrick Allen
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2023 Co-Supervisor The structural selectivity and various ligands of PPAR gamma Doctor of Philosophy Doctorate Full Time Mr Benjamin Soon Kai Chua 2017 - 2022 Principal Supervisor Molecular Drivers of Aerobic Glycolysis in the Mammalian Retina Doctor of Philosophy Doctorate Full Time Mr Cameron David Haydinger 2017 - 2023 Co-Supervisor Characterisation of Ovarian Cancer Development, Progression and Treatment Resistance Through Mass Spectrometry Analysis Doctor of Philosophy Doctorate Full Time Mitchell Aidan Acland 2017 - 2020 Principal Supervisor Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells Master of Philosophy Master Full Time Mr Yu Chinn Joshua Chey 2015 - 2021 Co-Supervisor Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2 Doctor of Philosophy Doctorate Full Time Miss Alexis Georgia Gerassimou 2014 - 2020 Principal Supervisor Investigating the Warburg effect and the role of pyruvate kinase M2 in retinal Müller glial cells Doctor of Philosophy Doctorate Full Time Miss Thaksaon Kittipassorn 2013 - 2018 Principal Supervisor Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Jacqueline-Alba Fabrizio 2012 - 2018 Co-Supervisor Regulation of Sphingosine Kinase 1 Oncogenic Signalling by Calcium and Integrin Binding Proteins Doctor of Philosophy Doctorate Part Time Ms Wenying Zhu 2011 - 2018 Principal Supervisor Investigating the Role of HIF-1 and HIF-2 Transcription Factors in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Natalia Magdalena Martin 2009 - 2016 Co-Supervisor Function and Regulation of Single-minded 1 and Single-minded 2 Transcription Factors in Disease Doctor of Philosophy Doctorate Full Time Ms Adrienne Sullivan 2007 - 2012 Principal Supervisor Characterising Ankyrin Repeat Proteins as Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Sarah Wilkins 2006 - 2012 Principal Supervisor Regulation of the Rgs4 Gene by the Hypoxia Inducible Factors Doctor of Philosophy Doctorate Full Time Mr Sam Olechnowicz 2006 - 2014 Co-Supervisor Regulation of Expression and Activity of the bHLH-PAS Transcription Factor NPAS4 Doctor of Philosophy Doctorate Full Time Dr David Bersten 2005 - 2016 Principal Supervisor Identification and Characterisation of Novel Substrates and Binding Partners of the Asparaginyl Hydroxylase, FIH Doctor of Philosophy Doctorate Part Time Ms Rachel Hampton-Smith 2005 - 2011 Principal Supervisor Investigating Potential Post-Translational Modification of Factor-Inhibiting HIF (FIH-1) Doctor of Philosophy Doctorate Full Time Ms Karolina Lisy 2004 - 2009 Co-Supervisor Gene Regulatory and Pro-Tumourigenic Mechanisms of the bHLH-PAS Transcription Factor SIM2s Doctor of Philosophy Doctorate Full Time Ms Alexandra Farrall 2004 - 2008 Principal Supervisor Substrate Specificity of Factor Inhibiting HIF-1 (FIH-1) Doctor of Philosophy Doctorate Full Time Dr Sarah Karttunen 2003 - 2005 Co-Supervisor Differential Function and Regulation of the Hypoxia Inducible Factors in the Rat Pheochromocytoma Cell Line Pc12 Doctor of Philosophy Doctorate Full Time Mr Anthony Fedele 2001 - 2005 Co-Supervisor Characterising the Differential Regulation of Hypoxia-Inducible Factor 1a and 2a Doctor of Philosophy Doctorate Full Time Dr Cameron Bracken
Date Role Membership Country 2009 - 2011 Member New York Academy of Sciences - 2004 - ongoing Member American Society of Biochemistry and Molecular Biology United States 2004 - ongoing Member Federation of American Societies for Experimental Biology United States 1990 - ongoing Member Australian Society of Biochemistry and Molecular Biology Australia
Date Role Editorial Board Name Institution Country 2015 - ongoing Consulting Editor Journal of Hypoxia University of Adelaide Australia
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