Dan Peet

Dr Dan Peet

Biochemistry and CMGD Lecturer

School of Biological Sciences

Faculty of Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Associate Professor Dan Peet's research interests are centred on understanding the molecular events within cells that underpin the genomic response to hypoxia. The cellular response to hypoxia is essential for many physiological processes in normal development and adult physiology, and contributes to the pathophysiology of major human diseases, including cancer, myocardial and cerebral ischaemia, pulmonary hypertension, and wound healing. The key components of this cellular response to hypoxia are a unique family of hydroxylase enzymes that act as the primary oxygen sensors, the Hypoxic Inducible transcription Factors (HIFs) that directly regulate gene expression, and specific target genes that mediate cellular changes. His research interests extend beyond the HIFs, to the identification and characterisation of novel substrates of the oxygen-sensing hydroxylases. Understanding these processes has major implications for the diagnosis, prognosis and novel therapeutic approaches to treat human disease.

A more recent focus is on cellular metabolism, specifically the unusual metabolism displayed by proliferating cells, especially cancer cells, that mimic quiescent cells in hypoxia. Of particular interest are the photoreceptor cells in the retina, which also display cancer-like metabolism. A key aim is to determine what controls this unusual metabolism, and whether it is a similar mechanism of control to cancer cells, with important implications for retinal disease.

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2017 Principal Supervisor Elucidating the Roles HIFI/HIFI2 on Multiple Myeloma Using an Inducible CRISPR/Cas9 System Master of Philosophy Master Full Time Mr Yu Chinn Joshua Chey
    2017 Co-Supervisor Characterising the Proteom of Invasive and Metastatic Ovarian Cancer Cells Doctor of Philosophy Doctorate Full Time Mitchell Aidan Acland
    2017 Principal Supervisor Role of Hypoxic Inducible Factors in Retinal Metabolism Doctor of Philosophy Doctorate Full Time Mr Cameron David Haydinger
    2015 Co-Supervisor Structure and Function of Basic Helix-Loop-Helix/Pas Transcription Factors Doctor of Philosophy Doctorate Full Time Miss Alexis Georgia Gerassimou
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2013 - 2018 Principal Supervisor Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Jacqueline-Alba Fabrizio
    2012 - 2018 Co-Supervisor Regulation of Sphingosine Kinase 1 Oncogenic Signalling by Calcium and Integrin Binding Proteins Doctor of Philosophy Doctorate Part Time Ms Wenying Zhu
    2011 - 2018 Principal Supervisor Investigating the Role of HIF-1 and HIF-2 Transcription Factors in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Natalia Magdalena Martin
    2009 - 2016 Co-Supervisor Function and Regulation of Single-minded 1 and Single-minded 2 Transcription Factors in Disease Doctor of Philosophy Doctorate Full Time Ms Adrienne Sullivan
    2007 - 2012 Principal Supervisor Characterising Ankyrin Repeat Proteins as Substrates of the Asparaginyl Hydroxylase FIH Doctor of Philosophy Doctorate Full Time Miss Sarah Wilkins
    2006 - 2012 Principal Supervisor Regulation of the Rgs4 Gene by the Hypoxia Inducible Factors Doctor of Philosophy Doctorate Full Time Mr Sam Olechnowicz
    2006 - 2014 Co-Supervisor Regulation of Expression and Activity of the bHLH-PAS Transcription Factor NPAS4 Doctor of Philosophy Doctorate Full Time Dr David Bersten
    2005 - 2011 Principal Supervisor Investigating Potential Post-Translational Modification of Factor-Inhibiting HIF (FIH-1) Doctor of Philosophy Doctorate Full Time Ms Karolina Lisy
    2005 - 2016 Principal Supervisor Identification and Characterisation of Novel Substrates and Binding Partners of the Asparaginyl Hydroxylase, FIH Doctor of Philosophy Doctorate Part Time Ms Rachel Hampton-Smith
    2004 - 2008 Principal Supervisor Substrate Specificity of Factor Inhibiting HIF-1 (FIH-1) Doctor of Philosophy Doctorate Full Time Dr Sarah Karttunen
    2004 - 2009 Co-Supervisor Gene Regulatory and Pro-Tumourigenic Mechanisms of the bHLH-PAS Transcription Factor SIM2s Doctor of Philosophy Doctorate Full Time Ms Alexandra Farrall
    2003 - 2005 Co-Supervisor Differential Function and Regulation of the Hypoxia Inducible Factors in the Rat Pheochromocytoma Cell Line Pc12 Doctor of Philosophy Doctorate Full Time Mr Anthony Fedele
    2001 - 2005 Co-Supervisor Characterising the Differential Regulation of Hypoxia-Inducible Factor 1a and 2a Doctor of Philosophy Doctorate Full Time Mr Cameron Bracken
  • Position: Biochemistry and CMGD Lecturer
  • Phone: 83135367
  • Email: dan.peet@adelaide.edu.au
  • Fax: 8313 4362
  • Campus: North Terrace
  • Building: Molecular Life Sciences, floor 3
  • Room: 3 40
  • Org Unit: Molecular and Biomedical Science

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