Higher Degree by Research Candidate
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
In 2022 I commenced a PhD in biochemistry at The University of Adelaide, supervised by Associated Professor Dan Peet and Dr David Bersten and Professor Darryl Russell of the Robinson Research Institute. My project is focussed on deciphering the roles of hypoxia (low oxygen) signalling in ovulation and in general physiology through developing cell-based high throughput drug screening systems. I have general interests in developing reporter systems for drug and genetic based screening purposes and understanding cell transcriptional regulation.
My research is focussed on hypoxic (low oxygen signalling). The first half of my project builds on my honours research where I established a high throughput cell-based screening system to identify novel regulators of hypoxic signalling proteins. In 2022 we received an Australian Government subsidised grant from the National Drug Discovery Centre to complete a 300,000 compound small molecule screen using these systems where we aim to identify novel drugs which could be used to control hypoxic signalling and therefore have applications in treating metabolic disease or ischemic diseases such as stroke.
The second half of my project is focussed on investigating the role of hypoxia in the control of ovulation. There are two main hypoxic proteins called HIF-1 and HIF-2, with evidence suggesting they are involved in ovulation. However, their exact role and mechanism of regulation remain undefined. I am interested in determining what specifically regulates HIF-2 activity in ovulation and its interplay with the Progesterone Receptor, which is a key controlling protein of ovulation. Furthermore, I aim to determine the specific role of HIF-2 in ovulation and how this differs from the role of HIF-1.
Awards and Achievements
Date Type Title Institution Name Country Amount 2023 Scholarship Robinson Research Institute travel grant The University of Adelaide United Kingdom $2000 2023 Scholarship Keystone Symposia travel grant The University of Adelaide Ireland $1800
Date Institution name Country Title 2021 - 2021 The University of Adelaide Australia Bachelor of Science (Honours) (Molecular and Biomedical Science) 2018 - 2020 The University of Adelaide Australia Bachelor of Science (Advanced) (Biochemistry and Genetics)
Date Role Committee Institution Country 2023 - ongoing Member The Society for Reproductive Biology - Australia 2022 - ongoing Board Member Adelaide Protein Group (APG) - Australia 2022 - ongoing Member Australian Society for Biochemistry and Molecular Biology - Australia
Date Topic Presented at Institution Country 2023 - 2023 Keystone Hypoxia short talk presentation Keystone Hypoxia: from basic mechanisms to emerging therapies. The University of Adelaide Ireland 2022 - 2022 ComBio conference short talk presentation National ComBio conference, as a member of ASBMB The University of Adelaide Australia
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