Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Tania Crotti is a research academic in the School of Medical Sciences at The University of Adelaide. She was awarded a BHealthSci (Hons) in 1997 then worked as a Research assistant in the Department of Pathology, University of Adelaide. In 2002 A/Prof. Crotti completed her PhD on the mechanisms responsible for pathological bone remodeling in inflammatory conditions (funded by a Dora Lush, NHMRC Scolarship).
A/Prof. Crotti subsequently worked as a postdoctoral fellow at the Harvard Affiliated Beth Israel Deaconess Medical Center, Boston USA 2003-2008. She was awarded a CJ Martin, NHMRC Fellowship to characterize the mechanisms regulating expression of the beta 3 integrin gene during osteoclast differentiation. In 2006 A/Prof. Crotti was awarded an American Arthritis Foundation Fellowship to investigate the role of cell-substrate interactions in regulating molecular pathways and genes associated with terminal osteoclast activation.
A/Prof. Crotti returned to Adelaide during 2008 to continue her work in the emerging field of Osteoimmunology. Her main research focus is to unravel the mediators of osteoclast differentiation and activation in order to arrest the localized bone loss associated with diseases such as periimplant loosening, periodontal disease and Rheumatoid Arthritis (RA). Her more recent interest extends to mechanisms and assessment of pain in RA.
A/Prof Crotti coordinates Biology for Nursing Practice (1st yr Nursing) and Investigative Cell Biology (3rd yr Bch Health and Med Science). In 2013 she was the recipient of a Faculty of Health Sciences Executive Dean’s Learning and Teaching Prize and Development Award and in 2017 received a Beacon award for Developing Coursework Students as Researchers. She is currently the Manager of Postgraduate Coordinators for the, Adelaide Medical School and is actively involved in the supervision of Honours and PhD students.
- My Research
- Grants and Funding
- Professional Activities
Associate Professor Crotti's primary research is in the field of pathological processes of bone and joint diseases, in particular, inflammation-induced bone loss (Osteoimmunology).
The Bone and Joint Research Laboratories carry out basic science and clinical research to explore three common bone pathologies: rheumatoid arthritis, periodontal disease and orthopaedic implant failure. More recently we have worked with the Paediatic Rheumatology department at the Women and Chirdren's Hospital, Adelaide to understand the experiences of children with Juvenile Idiopathic Arthritis. Other collaborative projects involve working with the Centre for Nanoscale Biophotonics at the University of Adelaide and the Rheumatology Division at Flinders University to explore the mechanisms of pain in inflammatory arthritis.
As an Education Specialist and member of the Adelaide Education Academy, Associate Professor Crotti is active in evidence-based teaching and research. Her particular interest is in the preparation of students for a career in research and authentic assessment.
Bone and Joint Osteoimmunology Laboratory
Research area: Musculoskeletal research: Bone and Joint Osteoimmunology Lab in Collaboration with Neuroinflammopharmacology and CNBP:
Research Project 1
Title: Bone and Joint histomorphometry and immunohistochemistry in a murine model of inflammatory arthritis and pain
Project description: Persistent pain and enhanced reactivity to pain, including that experienced in Rheumatoid Arthritis is now appreciated to involve bidirectional communication between the peripheral immune, spinal immune and brain immune systems. The Bone and Joint Osteoimmunology Lab utilise a murine animal model of inflammatory arthritis, the Collagen Antibody Induced Arthritis (CAIA) model. In collaboration with Neuroinflammopharmacology and the CNBP they aim to understand and modulate the signalling involved in inflammation, bone loss and pain. The aims of this project are: To analyse microCT imaging of the bone and joint 2. Immunohistochemistry analyses of the joint tissue to assess cells involved in bone turn over and pain receptors.
Projects available for: Third Year / Honours
Location: Helen Mayo Building
Research project start:
Semester 2 2020 Third Year
Semester 2 and 3 2020/2020 Honours
Special requirements: Nil
Research Project 2
Title: Objective assessment of pain in Rheumatoid Arthritis utilising neuroimmunology and biophotonics.
Project description: There are currently no objective tests to diagnose or quantify persistent pain. Nor are there tools to aid the selection of the best drug treatment for each patient. Persistent pain and enhanced reactivity to pain, including that experienced in RA, is now appreciated to involve bidirectional communication between the peripheral immune, spinal immune and brain immune systems. This project will extend our work from other persistent pain populations to create a novel diagnostic toolkit that can collectively provide an objective differential measure of musculoskeletal disease and pain experience. Using patient biological specimens and clinical data obtained in collaboration with the Rheumatology Department at the Flinders Clinical Centre we are applying novel hyperspectral imaging to objectively assess pain.
Projects available for: Third Year / Honours / HDR / Masters
Location: Helen Mayo Building- The Bone and Joint Immunology lab and the Centre for Nanoscale Biophotonics
Research project start: Semester 2
Special requirements: Police Clearance, vaccination required- the project will involve interaction with patients in the clinic to collect data and biostatistical analysis.
Research Project 3: Musculoskeletal research; Paediatric Health
Title:Understanding the complications and response to treatments in our SA population of Juvenile Idiopathic Arthritis
Project description: Juvenile idiopathic arthritis (JIA) is the most common disease seen in paediatric rheumatology clinics. In South Australia (SA) at the Women’s and Children’s Hospital (WCH), JIA is treated according to national and international published guidelines (Davies, Rheumatology 2010;). However, detailed clinical information about these patients is not easily available. We have recently established a data bank with ethical approval to continue to collect Patient Reported Experiences and clinical data such as: demographics, JIA subtype, disease onset, complications, juvenile arthritis disease activity scores, investigation results and treatment. Our overarching aim to better identify at risk populations, improve management and thus outcomes for our patients. Additionally, we aim to use the information we collect from patients with JIA to set up combined clinics between the rheumatology and other specialist departments in order to deliver wholistic care. In order to do so, current projects aim to 1. Understanding the patient experience. 2.Understand the prevalence and nature of comorbidities in the SA population 3 Understand the patient experience and significance of this in overall JIA management.
Projects available for: Third Year / Honours / HDR / Masters
Location: The Women and Childrens Hospital, North Adelaide
Research project start:
Special requirements: Police Clearance, vaccination required
Date Position Institution name 2019 Secretary Australian New Zealand Orthopaedice Research Society 2018 Postgraduate coordinator manager University of Adelaide, Adelaide 2014 Senior Lecturer University of Adelaide 2011 Lecturer University of Adelaide 2002 - 2003 Research Assistant, Department of Anatomy and Pathology University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Teaching Award Beacon Commendations for the Enhancement and Innovation of Student Learning University of Adelaide Australia $2000 2017 Fellowship Barbara Kidman Fellowship University of Adelaide Australia — 2013 Award Faculty of Health Sciences Executive Dean’s Learning and Teaching Prize and Development Award University of Adelaide Australia — 2012 Award Best Basic Science Poster for the Australian Rheumatology Association National meeting Australian Rheumatology Association Australia — 2011 Award Faculty International Conference Award (FICA) University of Adelaide — —
Date Institution name Country Title 1998 - 2002 University of Adelaide Australia PhD 1996 - 1996 University of Adelaide Australia Bach Hlth Sci (Hons) 1992 - 1995 University of Adelaide Australia Bach Hlth Sci
Date Title Institution Country 2008 - 2011 CJ Martin Fellow University of Adelaide Australia 2007 - 2008 American Arthritis Fellow Harvard Medical School United States 2003 - 2007 CJ Martin Fellow Harvard Medical School United States
Year Citation 2018 Williams, B., Tsangari, E., Crotti, T., & Dharmapatni, A. (2018). THE EFFECT OF AN N-CADHERIN ANTAGONIST ON JOINT INFLAMMATION AND BONE LOSS IN A MURINE MODEL OF COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA): PRELIMINARY STUDY. In INTERNAL MEDICINE JOURNAL Vol. 48 (pp. 9). WILEY.
2016 Wechalekar, M. D., Lester, S., Nagpal, S., Peters, J., Dash, A., Hissaria, P., . . . Proudman, S. M. (2016). Seropositivity Predicts Bone Biomarker Change in an Inception Cohort of Rheumatoid Arthritis Patients Treated-to-Target with Combination Conventional DMARD Therapy. In ARTHRITIS & RHEUMATOLOGY Vol. 68 (pp. 2 pages). WILEY. 2011 Crotti, T., Zawawi, M., Dharmapatni, A., Cantley, M., & Haynes, D. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. 2007 McHugh, K., Shen, Z., Crotti, T., Flannery, M., Fajardo, R., Bierbaum, B., & Goldring, S. (2007). Role of cell-matrix interactions in osteoclast differentiation. In Advances in Experimental Medicine and Biology Vol. 602 (pp. 107-111). United States.
DOI Scopus13 Europe PMC9
2004 Peters, K., Haynes, D., Crotti, T., Unger, R., & Kirkpatrick, C. (2004). Effects of wear particles from metallic implant materials on the pro-inflammatory state of endothelial cells in vitro. In Transactions - 7th World Biomaterials Congress (pp. 1150). 1999 Atkins, G. J., Loric, M., Crotti, T. N., Haynes, D. R., & Findlay, D. M. (1999). Osteoclast differentiation factors are expressed by both stromal and haematopoietic cells in human osteoclast formation. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 547-551). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD. 1999 Crotti, T. N., Potter, A. E., Atkins, G. J., Findlay, D. M., Howie, D. W., & Haynes, D. R. (1999). Osteoclast differentiation and development is regulated by mediators released in response to prosthetic particles. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 542-546). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD.
Year Citation 2017 Williams, B., Tsangari, E., Crotti, T., Perilli, E., & Dharmapatni, K. (2017). THE EFFECT OF EMBELIN, HYDROXYCHLOROQUINE (HCQ) AND THE COMBINATION OF EMBELIN AND HCQ ON JOINT INFLAMMATION, BONE LOSS AND APOPTOSIS IN A MURINE MODEL OF COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA). Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY. 2017 Wechalekar, M. D., Lester, S., Nagpal, S., Cole, S., Peters, J., Das, A., . . . Proudman, S. (2017). Osteopontin and Leptin Are Associated with Erosive Disease in an Inception Cohort of Rheumatoid Arthritis Treated-to-Target with Combination Conventional DMARD Therapy. Poster session presented at the meeting of ARTHRITIS & RHEUMATOLOGY. WILEY. 2016 Wechalekar, M., Lester, S., Nagpal, S., Cole, S., Das, A., Hissaria, P., . . . Proudman, S. (2016). RANKL, OPG AND OSCAR BUT NOT DKK-1 PREDICT RADIOGRAPHIC PROGRESSION IN AN INCEPTION COHORT OF SEROPOSITIVE RHEUMATOID ARTHRITIS (RA) TREATED-TO-TARGET WITH COMBINATION CONVENTIONAL DMARD THERAPY. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP.
2016 Crotti, T., Coleman, R., Dharmapatni, A., Weedon, H., Haynes, D., Smith, M., & Wechalekar, M. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP.
2014 Purdue, E., Hill, J., Goldring, S., Crotti, T., Nabozny, G., & McHugh, K. (2014). Bone substrate and Integrin beta 3 regulate critical pathways of cell cycle progression, proliferation and survival during terminal osteoclast differentiation.. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Houston, TX: WILEY-BLACKWELL. 2014 Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL. 2013 Dharmapatni, A., Wechalekar, M., Haynes, D., Smith, M., & Crotti, T. (2013). RELATIONSHIP BETWEEN SOLUBLE OSCAR AND EROSION, A PRELIMINARY STUDY. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL. 2013 Dharmapatni, A., Coleman, R., Lorimer, M., Zannettino, A., Weedon, H., Wechalekar, M., . . . Crotti, T. (2013). Relationship between Soluble OSCAR and Disease Activity: A 12 Month Study of Newly Diagnosed RA Patients. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL. 2012 Crotti, T., Alias, E., Dharmapatni, A., Weedon, H., Zannettino, A., & Smith, M. (2012). EVIDENCE THAT VASCULAR EXPRESSION OF THE ITAM RECEPTOR, OSCAR, IN ACTIVE RHEUMATOID ARTHRITIS IS MODULATED BY INFLAMMATORY MEDIATORS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL. 2012 Dharmapatni, K., Findlay, D., Alias, E., Holding, C., Atkins, G., Howie, D., . . . Haynes, D. (2012). Polyethylene particles stimulate osteoclasts in vivo and in vitro in association with enhanced expression of ITAM-related molecules. Poster session presented at the meeting of BONE. Stockholm, SWEDEN: ELSEVIER SCIENCE INC.
Arthritis Australia Project Grant
Australian Dental Research Foundation Grant
|2015||Marion A Simpson Grant, Arthritis Australia “Abrogating Inflammation and Bone Loss in a Mouse Model of Inflammatory Arthritis” $25K|
|2015||American Society for Bone and Mineral Research (ASBMR) Grants in Aid Program (GAP) Award “OSCAR, A Serum Marker of Joint Erosion Enabling Treatment Modification” $60K|
|2013||The Allan and Beryl Stephens Grant, Arthritis Australia “OSCAR as a marker of disease activity in rheumatoid arthritis.” $25K|
|2011||New Appointment Grant Funding, School of Medical Sciences, The University of Adelaide $15K|
|2009-2012||CIE on NHMRC Project Grant (ID:565361) “Regulation of Peri-implant Bone Loss.”|
|2008-2011||Post-doctoral support National Health and Medical Research Council (Aust) CJ Martin Fellowship (ID:200078). “Molecular Mechanisms of Bone loss in Osteoporosis and Inflammatory Disorders.”|
Contributions to Teaching and Training
Symposium Lead on Authentic Assessment:Transforming Futures: International Perspectives on Research Based Education Conference 2019
Supervisor - Student Relationship CaRST Workshops, FHMS
Invited Speaker: Adelaide Women Forum, University of Adelaide Promotion workshop
Invited Speaker: AMS Women’s Development and Promotion workshop
Postgraduate Coordinator Manager, Adelaide Medical School
Senior Postgraduate Coordinator, Adelaide Medical School
Design and Deliver HDR Induction workshops, Adelaide Medical School
Anatomy and Pathology Postgraduate coordinator
Coordinator for NURS 1005: Biology for Nursing Practice
Coordinator for PATHOL 3104: Investigative Cell Biology
Lecturer in the Discipline of Anatomy and Pathology, The University of Adelaide
University Leadership and Committees
|2019||Student Matters Sub-committee (SMS), Faculty of Health and Medical Sciences (FHMS) Representative, UoA|
ITDS Research and Innovation reference Group
FHMS Well Being Working Group Member
Human Biology Common Curriculum Steering Group Member
Chair of Adelaide Medical School (AMS) PGC Committee, FHMS
FHMS HDR Committee Member
Postgraduate Coordinator Manager, The Adelaide Medical School (AMS)
CaRST Online Postgraduate Coordinator Focus Group Member
CCSP Online Postgraduate Coordinator Focus Group Member
HDR Enrolment Online Postgraduate Coordinator Focus Group Member
AMS Research Education Committee Member
Honours Working Group Committee - development of common curriculum for School of Medical Sciences
School of Medical Sciences Executive Advisory Committee (SEAC) Member
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Principal Supervisor Regulating Periodontitis through a Topical Treatment Doctor of Philosophy Doctorate Full Time Mr Adrian Dale Duran 2018 Principal Supervisor Assessing Pain and Treatment Responsiveness in a Patient Cohort and Mouse Model of Inflammatory Arthritis Using Neurobiophotonics Doctor of Philosophy Doctorate Full Time Miss Florence Jade Lees 2018 Principal Supervisor The Establishment of Registry for Juvenile Idiopathic Arthritis patients in South Australia Doctor of Philosophy Doctorate Full Time Miss Ming Min
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2019 Principal Supervisor Pharmacological Modulation of Inflammation, Bone Loss and Pain in a Murine Model of Inflammatory Arthritis Doctor of Philosophy Doctorate Full Time Miss Bonnie Williams 2011 - 2015 Co-Supervisor Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis Doctor of Philosophy Doctorate Full Time Mr Muhamad Syahrul Fitri Zawawi 2008 - 2014 Co-Supervisor Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis Doctor of Philosophy Doctorate Full Time Mr Ekram Alias
Date Role Committee Institution Country 2019 - ongoing Member Student Matters Sub-committee (SMS) of the Research Education and Development Committee (REDC) University of Adelaide Australia 2018 - ongoing Secretary Scientific Review Committee Australian New Zealand Orthopaedic Research (ANZORS) Committee Scientific Review Committee Australian New Zealand Orthopaedic Research (ANZORS) Committee Australia 2018 - ongoing Member Member of the FHMS Wellbeing Working Group The University of Adelaide Australia 2018 - ongoing Member ITDS Research and Innovation reference group The University of Adelaide Australia 2018 - ongoing Member Human Biology Common Curriculum Human Biology Steering Group The University of Adelaide Australia 2018 - ongoing Member National Health and Medical Research Council (NHMRC) Grant Review Panel (GRP) member National Health and Medical Research Council (NHMRC) Australia 2018 - ongoing Member Faculty of Health and Medical Science International Scholarship Ranking Committee The University of Adelaide Australia 2018 - ongoing Chair Adelaide Medical School (AMS) Research Education Committee The University of Adelaide Australia 2017 - ongoing Member Adelaide Medical School (AMS) Research Committee University of Adelaide Australia 2016 - 2018 Member Arthritis Australia Grant Assessment Committee Arthritis Australia Australia 2016 - ongoing Board Member Faculty of Health & Medical Sciences Higher Degrees Committee The University of Adelaide Australia 2015 - ongoing Member International Bone Mineral Society (IBMS) Young Investigator Committee International Bone Mineral Society Australia 2014 - ongoing Member Scientific Review Committee Australian New Zealand Orthopaedic Research (ANZORS) Committee ANZORS Australia 2012 - 2015 Member School of Medical Sciences HDR and Honours committee Universoty of Adelaide Australia 2012 - 2012 Member School Honours Programme Working Group University of Adelaide Australia 2012 - ongoing Member National Health and Medical Research Council’s (NHMRC’s) Postdoctoral Reference Group NHMRC Australia 2011 - 2011 Member School Executive Advisory Council (SEAC) University of Adelaide — 2010 - ongoing Secretary Adelaide Bone Group Committee Seminar Series Adelaide Bone Group Australia
Date Role Membership Country 2017 - ongoing Member Education Academy Australia 2013 - ongoing Member Australian Rheumatology Association Australia 2010 - ongoing Member Australian and New Zealand Society of Bone and Mineral Research Australia 2010 - ongoing Member Adelaide Bone Joint Meeting Seminar Series Australia 2008 - ongoing Member Australian and New Zealand Orthopaedic Research Society Australia 2007 - ongoing Member Orthopaedic Research Society — 2001 - ongoing Member American Society of Bone and Mineral Research United States
Date Role Editorial Board Name Institution Country 2016 - ongoing Associate Editor Inflammopharmacology University of Adelaide Australia
Date Office Name Institution Country 2018 - ongoing Postgraduate Coordinator Manager, Adelaide Medical School University of Adelaide Australia
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