Associate Professor Wendy Ingman

Ext-Funded Research Fellow (D)

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Wendy is a breast health expert and leads multi-disciplinary research that integrates biomedical, clinical and public health approaches. Her research interests span breast cancer, breastfeeding and breast development. Current research projects include identifying the impact of menstrual cycling on predictive breast cancer tests, development of a new technology for early breast cancer detection, defining the underlying biology of mammographic density as a breast cancer risk factor, and establishing a new paradigm for lactation mastitis.

Wendy provides commentary and professional education for the community and healthcare sectors on breast issues including breast cancer and breastfeeding. She is passionate about the importance of community education and advocates for women to be well-informed about how to take control of their own breast health. She has provided expert advice and education for a number of national organisations including BreastScreen Australia, the Australian Breastfeeding Association, and the Clinical Oncology Society of Australia. Wendy founded and currently leads a national alliance of breast cancer researchers called InforMD (visit www.informd.org.au for more information), who are highly active in public health policy and community awareness.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

Ahead of her lecture at the GOLD Lactation Online Conference in 2021, Wendy spoke to Fiona Lang-Sharpe about what inspires her in her work, and why breast research is so important.

Improving breast health throughout the life course

The breast is a unique organ, because it goes through most of its development a long time after birth. For example, puberty is a really important phase in breast development, as is pregnancy. This development is key in enabling the breast to perform its critical function in producing milk to nurture a new baby, but it also affects the risk of breast cancer for a woman's entire life. We know that the breast is the most susceptible tissue in a woman's body for developing cancer, so it's very important to understand how it grows and functions. Our research focus is on studying how the breast functions and how disease states can develop in the breast, such as breast cancer and lactation mastitis, and how this information can be used to improve women's breast health for the life course.

Breast Biology & Cancer Unit - 'prevention for the future'

Wendy leads the Breast Biology & Cancer Unit, based at The Queen Elizabeth Hospital. The research focus is on understanding the underlying biology of breast function and risk of disease. The Unit works closely with a broad range of clinicians, communication experts and community groups so that new discoveries will translate into improved prevention, detection and treatment decision-making, with the ultimate goal to improve breast health outcomes. Research projects are available for Honours, Masters and PhD students.

BBCU

Breast cancer prevention research

Breast cancer places an incredible burden on Australian women. Every year, around 20,000 Australian women are diagnosed with breast cancer alone - a disease that devastates people's lives and is often fatal. If we are to prevent breast cancer, we must better understand how the disease develops. This research studies the biological mechanisms of two different risk factors - breast density and menstrual cycling.

Why breast density matters in prevention and detection of breast cancer

Breast density (also known as mammographic density) is the percentage of white and bright regions on a mammogram. Breast density is not related to how breasts look or feel and can only be assessed by mammogram. High breast density is both an independent risk factor for breast cancer and masks cancers on a mammogram. Combined, these two distinct phenomena lead to increased incidence, delayed diagnosis, more aggressive tumours, and a 90% increased risk of breast cancer-associated death in women with high breast density. Learn more about breast density here.

Despite the difficulties breast density cause in the detection of breast cancer, there is exciting potential for breast density to become a widespread health assessment tool, used to identify the women most at risk of breast cancer in order to intervene early and reduce that risk. Our research is the first to demonstrate a causal role for immune system signalling in breast density and the associated cancer risk, opening the door for new approaches to reduce breast cancer risk through use of anti-inflammatory drugs in women with dense breasts. Find out more about this discovery in Wendy's ABC Health Report podcast with Dr Norman Swan.

Immune cells open a window of breast cancer risk each menstrual cycle

Menstrual cycling increases a woman's risk of breast cancer. For each year younger a girl starts menstruating (i.e. having a period each month), there is a 5% increased risk of breast cancer over her lifetime. Our research has focused on immune cells known as macrophages in the breast, and how the role of these cells changes because of fluctuations in hormones during different times of the month. We have discovered that while the immune cells have a role to play in the normal function of the breast, at certain stages in the menstrual cycle they may help to make the breast more susceptible to cancer. Learn more about this discovery here.

Improving breast cancer treatment decision-making

Gene expression profiling of breast cancer is a technology increasingly being adopted in the clinic as a precision medicine approach to tailor treatment to individual patients. However, an underappreciated factor in breast cancer diagnosis in young women is that oestrogen and progesterone fluctuate dramatically during the menstrual cycle, and these hormones are likely to affect gene expression. We have shown that the menstrual cycle can affect precision medicine which could in turn affect treatment decision-making.

Lactation mastitis and breastfeeding research

Lactation mastitis is an inflammatory breast disease affecting 1 of 5 Australian breastfeeding women. It causes pain, fever and low milk supply. The challenges posed by this disease lead many women to use supplementary formula, or cease breastfeeding altogether leaving their infants at increased risk of respiratory and gastrointestinal diseases as babies, and non-communicable diseases including heart disease, obesity, diabetes, cancer, allergies, asthma, mental illness and chronic lung, liver and renal diseases as both children and adults. Our research has suggested that macrophages play a role in development of this disease. We are now exploring revolutionary new concepts of how immune cells function in the breast, and how these cells affect breast disease development. Learn more about lactation mastitis in Wendy's podcast for the Australian Breastfeeding Association.

Appointments

Date	Position	Institution name
2011 - ongoing	Associate Professor	University of Adelaide
2009 - 2010	Research Fellow	University of Adelaide
2008 - 2008	Postdoctoral Research Officer	University of Adelaide
2003 - 2008	CJ Martin Fellow	University of Adelaide and Albert Einstein College of Medicine
2002 - 2003	Research Officer	Adelaide University
1998 - 1998	Research Assistant	Queen Elizabeth Hospital

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2016	Award	Award for Excellence in Reproductive Biology Research	Society for Reproductive Biology	Australia	-
2016	Award	Women’s Research Excellence Awards	University of Adelaide	Australia	-
2012	Award	SA Leading Light Award Finalist	Australian Society for Medical Research	-	-
2011	Recognition	Most Outstanding Research Paper published in 2011	University of Adelaide	Australia	-
2010	Recognition	Excellence in Research Supervision	University of Adelaide	Australia	-
2008	Award	Best Presentation by Postdoctoral Fellow	Network of Genes and Environment in Development	Australia	-
2007	Award	Most Outstanding Early Career Researcher	University of Adelaide	Australia	-
2007	Recognition	Most Outstanding Research Paper published in 2007	University of Adelaide	Australia	-
2005	Award	Tall Poppy Science Award	Australian Institute of Political Science	-	-
2003	Fellowship	NHMRC CJ Martin Fellowship	NHMRC	Australia	-
2003	Scholarship	World Academy of Arts and Science’s Emily Hartshorne Mudd Scholarship & C. Lalor Burdick Scholarship	-	-	-
2002	Award	Young Investigator Award, finalist	Women’s and Children’s Hospital	-	-
2001	Award	Ross Wishart Award	Australian Society for Medical Research	Australia	-
2001	Award	Find of National Science Week	-	Australia	-
2001	Award	Junior Scientist Award, 1st place	Society for Reproductive Biology	Australia	-
2001	Research Award	Trainee Research Award, 2nd place	Society for the Study of Reproduction	Australia	-
1998	Award	Australian Postgraduate Award	-	-	-
1997	Award	Junior Scientist Award, finalist	Australian Society for Reproductive Biology	-	-

Education

Date Institution name Country Title
1998 - 2002 University of Adelaide Australia PhD
1993 - 1997 University of Adelaide Australia BSc
Research Interests

Cancer Cell Biology Immunology Obstetrics & Reproductive Medicine Obstetrics and Gynaecology Reproduction Reproductive Biology Cancer Biology and Clinical Oncology Surgical and Health Systems Innovation Pregnancy and Birth Translational Health Outcomes

Date	Institution name	Country	Title
1998 - 2002	University of Adelaide	Australia	PhD
1993 - 1997	University of Adelaide	Australia	BSc

Journals

Year	Citation
2022	Grzeskowiak, L. E., Saha, M. R., Ingman, W. V., Nordeng, H., Ystrom, E., & Amir, L. H. (2022). Incidence, antibiotic treatment and outcomes of lactational mastitis: Findings from The Norwegian Mother, Father and Child Cohort Study (MoBa). Paediatric and Perinatal Epidemiology, 36(2), 254-263. DOI Scopus1 WoS1
2022	Archer, M., Dasari, P., Walsh, D., Britt, K. L., Evdokiou, A., & Ingman, W. V. (2022). Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density. Journal of Clinical Medicine, 11(3), 799-1-799-21. DOI Scopus2 WoS2 Europe PMC2
2022	Bray, H. J., Stone, J., Litchfield, L., Britt, K. L., Hopper, J. L., & Ingman, W. V. (2022). Together Alone: Going Online during COVID-19 Is Changing Scientific Conferences. Challenges, 13(1), 7-1-7-13. DOI
2022	Tower, H., Dall, G., Davey, A., Stewart, M., Lanteri, P., Ruppert, M., . . . Britt, K. L. (2022). Estrogen-induced immune changes within the normal mammary gland. Scientific Reports, 12(1), 14 pages. DOI WoS1
2021	Archer, M., Dasari, P., Evdokiou, A., & Ingman, W. V. (2021). Biological mechanisms and therapeutic opportunities in mammographic density and breast cancer risk. Cancers, 13(21), 1-21. DOI
2021	Ghadge, A. G., Dasari, P., Stone, J., Thompson, E. W., Robker, R. L., & Ingman, W. V. (2021). Pubertal mammary gland development is a key determinant of adult mammographic density. Seminars in Cell and Developmental Biology, 114, 143-158. DOI Scopus8 WoS7 Europe PMC5
2021	Kam, R. L., Bernhardt, S. M., Ingman, W. V., & Amir, L. H. (2021). Modern, exogenous exposures associated with altered mammary gland development: A systematic review.. Early Hum Dev, 156, 1-15. DOI Scopus4 WoS4
2021	Sun, X., Bernhardt, S. M., Glynn, D. J., Hodson, L. J., Woolford, L., Evdokiou, A., . . . Ingman, W. V. (2021). Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice. Breast Cancer Research, 23(1), 39-1-39-16. DOI Scopus6 WoS8 Europe PMC3
2021	Bernhardt, S. M., Dasari, P., Glynn, D. J., Townsend, A. R., Price, T. J., & Ingman, W. V. (2021). Comparison of hormone-induced mRNA and protein biomarker expression changes in breast cancer cells. Breast cancer research and treatment, 187(3), 681-693. DOI
2021	Bernhardt, S. M., Dasari, P., Glynn, D. J., Woolford, L., Moldenhauer, L. M., Walsh, D., . . . Ingman, W. V. (2021). Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours.. BMC Cancer, 21(1), 1-12. DOI Scopus2 WoS2 Europe PMC2
2020	Bernhardt, S. M., Dasari, P., Walsh, D., Townsend, A. R., Price, T. J., & Ingman, W. V. (2020). Timing of breast cancer surgery during the menstrual cycle-is there an optimal time of the month?. Oncology letters, 20(3), 2045-2057. DOI Scopus3 WoS1 Europe PMC1
2020	Bernhardt, S. M., Dasari, P., Wrin, J., Raymond, W., Edwards, S., Walsh, D., . . . Ingman, W. V. (2020). Discordance in 21-gene recurrence scores between paired breast cancer samples is inversely associated with patient age. Breast Cancer Res, 22(1), 1-10. DOI Scopus7 WoS6 Europe PMC5
2020	Bernhardt, S. M., Dasari, P., Walsh, D., Raymond, W., Hull, M. L., Townsend, A. R., . . . Ingman, W. V. (2020). The menstrual cycle is an under-appreciated factor in premenopausal breast cancer diagnosis and treatment. Current Opinion in Endocrine and Metabolic Research, 15, 37-42. DOI Scopus2
2020	Ingman, W. V. (2020). Deep imaging reveals new insights into mammary gland architecture and breast cancer susceptibility. FEBS Journal, 287(2), 246-249. DOI
2020	Ingman, W. V., Richards, B., Street, J. M., Carter, D., Rickard, M., Stone, J., & Dasari, P. (2020). Breast density notification: an Australian perspective. Journal of Clinical Medicine, 9(3), 681-1-681-8. DOI Scopus5 WoS5 Europe PMC1
2020	Atashgaran, V., Dasari, P., Hodson, L. J., Evdokiou, A., Barry, S. C., & Ingman, W. V. (2020). Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice. Reproduction, Fertility and Development, 32(8), 774-782. DOI
2019	Johan, M. Z., Ingman, W. V., Robertson, S. A., & Hull, M. L. (2019). Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model. Journal of Reproductive Immunology, 132, 1-8. DOI Scopus16 WoS14 Europe PMC9
2019	Ingman, W. V. (2019). The Gut Microbiome: A New Player in Breast Cancer Metastasis. Cancer Research, 79(14), 3539-3541. DOI Scopus27 WoS27 Europe PMC19
2018	Hugo, H. J., Zysk, A., Dasari, P., Britt, K., Hopper, J. L., Stone, J., . . . Ingman, W. V. (2018). InforMD: A new initiative to raise public awareness about breast density. ecancermedicalscience, 12, 807. DOI Scopus2 Europe PMC1
2017	Anderson, R., Ingman, W., & Britt, K. (2017). Editorial: How reproductive history influences our breast cancer risk. Frontiers in Oncology, 7(DEC), 289-1-289-4. DOI Scopus3 WoS2
2017	Sun, X., Glynn, D., Hodson, L., Huo, C., Britt, K., Thompson, E., . . . Ingman, W. (2017). CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model. Breast Cancer Research, 19(1), 4-1-4-15. DOI Scopus43 WoS43 Europe PMC32
2017	Panagopoulos, V., Leach, D., Zinonos, I., Ponomarev, V., Licari, G., Liapis, V., . . . Evdokiou, A. (2017). Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment. International Journal of Oncology, 50(4), 1191-1200. DOI Scopus25 WoS25 Europe PMC22
2017	Liapis, V., Zysk, A., DeNichilo, M., Zinonos, I., Hay, S., Panagopoulos, V., . . . Evdokiou, A. (2017). Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma. Cancer Medicine, 6(9), 2164-2176. DOI Scopus7 WoS7 Europe PMC4
2017	Panagopoulos, V., Liapis, V., Zinonos, I., Hay, S., Leach, D. A., Ingman, W., . . . Evdokiou, A. (2017). Peroxidase enzymes inhibit osteoclast differentiation and bone resorption. Molecular and Cellular Endocrinology, 440(C), 8-15. DOI Scopus11 WoS13 Europe PMC7
2017	Zysk, A., DeNichilo, M., Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., . . . Evdokiou, A. (2017). Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer. Cancer Letters, 386, 141-150. DOI Scopus15 WoS15 Europe PMC11
2016	Bernhardt, S. M., Dasari, P., Walsh, D., Townsend, A. R., Price, T. J., & Ingman, W. V. (2016). Hormonal modulation of breast cancer gene expression: implications for intrinsic subtyping in premenopausal women. Frontiers in Oncology, 6(NOV), 241-1-241-16. DOI Scopus20 WoS20 Europe PMC14
2016	Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2016). Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models. Cancer Medicine, 5(3), 534-545. DOI Scopus22 WoS20 Europe PMC19
2016	Huo, C., Huang, D., Chew, G., Hill, P., Vohora, A., Ingman, W., . . . Britt, K. (2016). Human glandular organoid formation in murine engineering chambers after collagenase digestion and flow cytometry isolation of normal human breast tissue single cells. Cell Biology International, 40(11), 1212-1223. DOI Scopus2 WoS2 Europe PMC2
2016	Atashgaran, V., Wrin, J., Barry, S., Dasari, P., & Ingman, W. (2016). Dissecting the biology of menstrual cycle-associated breast cancer risk. Frontiers in Oncology, 6(DEC), 1-10. DOI Scopus29 WoS28 Europe PMC19
2016	Boyle, S., Ingman, W., Poltavets, V., Faulkner, J., Whitfield, R., McColl, S., & Kochetkova, M. (2016). The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells. Oncogene, 35(1), 105-115. DOI Scopus29 WoS29 Europe PMC22
2015	Ingman, W., Glynn, D., & Hutchinson, M. (2015). Mouse models of mastitis - how physiological are they?. International Breastfeeding Journal, 10(1), 12-1-12-5. DOI Scopus12 WoS13 Europe PMC12
2015	Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2015). Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Letters, 357(1), 160-169. DOI Scopus38 WoS36 Europe PMC30
2015	Panagopoulos, V., Zinonos, I., Leach, D., Hay, S., Liapis, V., Zysk, A., . . . Evdokiou, A. (2015). Uncovering a new role for peroxidase enzymes as drivers of angiogenesis. The International Journal of Biochemistry and Cell Biology, 68, 128-138. DOI Scopus21 WoS21 Europe PMC12
2015	Need, E., Selth, L., Trotta, A., Leach, D., Giorgio, L., O'Loughlin, M., . . . Buchanan, G. (2015). The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype. BMC Cancer, 15(1), 791-1-791-17. DOI Scopus27 WoS25 Europe PMC23
2015	Huo, C., Chew, G., Hill, P., Huang, D., Ingman, W., Hodson, L., . . . Britt, K. (2015). High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium. Breast Cancer Research, 17(1), 79-1-79-20. DOI Scopus107 WoS99 Europe PMC86
2014	Zinonos, I., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., Denichilo, M., . . . Evdokiou, A. (2014). Doxorubicin overcomes resistance to drozitumab by antagonizing inhibitor of apoptosis proteins (IAPS). Anticancer Research, 34(12), 7007-7020. Scopus5 WoS4 Europe PMC3
2014	Care, A., Ingman, W., Moldenhauer, L., Jasper, M., & Robertson, S. (2014). Ovarian steroid hormone-regulated uterine remodeling occurs independently of macrophages in mice. Biology of Reproduction, 91(3), 60-1-60-12. DOI Scopus11 WoS10 Europe PMC8
2014	Zinonos, I., Luo, K., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., . . . Evdokiou, A. (2014). Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer. International Journal of Oncology, 45(2), 532-540. DOI Scopus19 WoS19 Europe PMC13
2014	Need, E., Atashgaran, V., Ingman, W., & Dasari, P. (2014). Hormonal regulation of the immune microenvironment in the mammary gland. Journal of Mammary Gland Biology and Neoplasia, 19(2), 229-239. DOI Scopus35 WoS33 Europe PMC23
2014	Ingman, W. V. (2014). Preface. Journal of Mammary Gland Biology and Neoplasia, 19(2), 147-148. DOI
2014	Sun, X., & Ingman, W. (2014). Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer. Journal of Mammary Gland Biology and Neoplasia, 19(2), 191-201. DOI Scopus21 WoS20 Europe PMC14
2014	Huo, C., Chew, G., Britt, K., Ingman, W., Henderson, M., Hopper, J., & Thompson, E. (2014). Mammographic density - a review on the current understanding of its association with breast cancer. Breast Cancer Research and Treatment, 144(3), 479-502. DOI Scopus145 WoS139 Europe PMC101
2014	Glynn, D., Hutchinson, M., & Ingman, W. (2014). Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction, 90(5), 1-11. DOI Scopus24 WoS24 Europe PMC18
2014	Ingman, W., Glynn, D., & Hutchinson, M. (2014). Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia, 19(2), 161-167. DOI Scopus45 WoS44 Europe PMC28
2014	Dasari, P., Sharkey, D., Noordin, E., Glynn, D., Hodson, L., Chin, P., . . . Ingman, W. (2014). Hormonal regulation of the cytokine microenvironment in the mammary gland. Journal of Reproductive Immunology, 106, 58-66. DOI Scopus14 WoS14 Europe PMC11
2013	Hodson, L., Chua, C., Evdokiou, A., Robertson, S., & Ingman, W. (2013). Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones. Biology of Reproduction, 89(3), 1-8. DOI Scopus24 WoS24 Europe PMC17
2013	Care, A., Diener, K., Jasper, M., Brown, H., Ingman, W., & Robertson, S. (2013). Macrophages regulate corpus luteum development during embryo implantation in mice. Journal of Clinical Investigation, 123(8), 3472-3487. DOI Scopus153 WoS137 Europe PMC92
2013	Sun, X., Robertson, S., & Ingman, W. (2013). Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland. Cytokine (Online), 61(2), 377-388. DOI Scopus16 WoS15 Europe PMC12
2012	Hull, M., Johan, M., Hodge, W., Robertson, S., & Ingman, W. (2012). Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis. American Journal of Pathology, 180(3), 880-887. DOI Scopus61 WoS55 Europe PMC36
2011	Ricciardelli, C., Frewin, K., Tan, I., Williams, E., Opeskin, K., Pritchard, M., . . . Russell, D. (2011). The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. American Journal of Pathology, 179(6), 3075-3085. DOI Scopus54 WoS48 Europe PMC46
2011	Peters, A., Ingman, W., Tilley, W., & Butler, L. (2011). Differential effects of exogenous androgen and an androgen receptor antagonist in the peri- and postpubertal murine mammary gland. Endocrinology, 152(10), 3728-3737. DOI Scopus51 WoS45 Europe PMC37
2011	Jasper, M., Care, A., Sullivan, B., Ingman, W., Aplin, J., & Robertson, S. (2011). Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy. Biology of Reproduction, 84(1), 179-188. DOI Scopus48 WoS44 Europe PMC30
2010	Chua, C., Hodson, L., Moldenhauer, L., Robertson, S., & Ingman, W. (2010). Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium. Development, 137(24), 4229-4238. DOI Scopus58 WoS58 Europe PMC46
2010	Ingman, W., McGrath, L., Breed, W., Musgrave, I., Robker, R., & Robertson, S. (2010). The mechanistic basis for sexual dysfunction in male transforming growth factor β1 null mutant mice. Journal of Andrology, 31(2), 95-107. DOI Scopus5 WoS5 Europe PMC4
2010	Care, A. S., Jasper, M. J., Ingman, W. V., & Robertson, S. A. (2010). An essential role for macrophages in corpus luteum function and early pregnancy maintenance. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 86(1), 55. DOI
2009	Ingman, W., & Robertson, S. (2009). The essential roles of TGFB1 in reproduction. Cytokine & Growth Factor Reviews, 20(3), 233-239. DOI Scopus49 WoS45 Europe PMC27
2009	McGrath, L., Ingman, W., Robker, R., & Robertson, S. (2009). Exogenous transforming growth factor beta1 replacement and fertility in male Tgfb1 null mutant mice. Reproduction Fertility and Development, 21(4), 561-570. DOI Scopus4 WoS4 Europe PMC3
2008	Ingman, W., & Robertson, S. (2008). Mammary gland development in transforming growth factor beta1 null mutant mice: Systemic and epithelial effects. Biology of Reproduction, 79(4), 711-717. DOI Scopus34 WoS29 Europe PMC23
2008	Ingman, W., & Jones, R. (2008). Cytokine knockouts in reproduction: The use of gene ablation to dissect the roles of cytokines in reproductive biology. Human Reproduction Update, 14(2), 179-192. DOI Scopus42 WoS36 Europe PMC17
2007	Ingman, W. V., & Robertson, S. A. (2007). Transforming growth factor-beta 1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. ENDOCRINOLOGY, 148(8), 4032-4043. DOI WoS45
2007	Ingram, W., & Robertson, S. (2007). Transforming growth factor-β1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology, 148(8), 4032-4043. DOI Scopus46 Europe PMC32
2006	Ingman, W., Wyckoff, J., Gouon-Evans, V., Condeelis, J., & Pollard, J. (2006). Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Developmental Dynamics, 235(12), 3222-3229. DOI Scopus200 WoS193 Europe PMC161
2006	Ingman, W., Robker, R., Woittiez, K., & Robertson, S. (2006). Null mutation in transforming growth factor β1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology, 147(2), 835-845. DOI Scopus67 WoS63 Europe PMC45
2003	Ingman, W. V., & Robertson, S. A. (2003). Erectile dysfunction leads to infertility in TGF beta 1 null mice.. BIOLOGY OF REPRODUCTION, 68, 375.
2002	Ingman, W., & Robertson, S. (2002). Defining the actions of transforming growth factor beta in reproduction. Bioessays, 24(10), 904-914. DOI Scopus103 WoS93 Europe PMC63
2002	Robertson, S., Ingman, W., O'Leary, S., Sharkey, D., & Tremellen, K. (2002). Transforming growth factor β — a mediator of immune deviation in seminal plasma. Journal of Reproductive Immunology, 57(1-2), 109-128. DOI Scopus237 WoS211 Europe PMC153
2001	Ingman, W. V., & Robertson, S. A. (2001). Impaired ovarian function and preimplantation embryo development in transforming growth factor beta 1 null mutant mice.. BIOLOGY OF REPRODUCTION, 64, 107.
2000	Ingman, W., Owens, P., & Armstrong, D. (2000). Differential regulation by FSH and IGF-I of extracellular matrix IGFBP-5 in bovine granulosa cells: effect of association with the oocyte. Molecular and Cellular Endocrinology, 164(1-2), 53-58. DOI Scopus12 WoS11 Europe PMC9
-	Bernhardt, S. M., Dasari, P., Glynn, D. J., Woolford, L., Moldenhauer, L. M., Walsh, D., . . . Ingman, W. V. (n.d.). Estrous cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours. DOI

Book Chapters

Year	Citation
2006	Ingman, W., Wyckoff, J., Xue, C., Lin, E., Wang, W., Goswami, S., . . . Segall, J. (2006). Imaging Invasion and Metastasis In Vivo. In Alan Wells (Ed.), Cell motility in cancer invasion and metastasis (pp. 55-73). Berlin: Springer. DOI

Conference Papers

Year	Citation
2015	Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., Ingman, W., Iasiello, M. P., . . . Evdokiou, A. (2015). Uncovering a new role for peroxidases in breast cancer development and metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 32 (pp. 227-228). SPRINGER.
2015	Huo, C. W., Huang, D., Chew, G. L., Hill, P., Ingman, W. V., Henderson, M., . . . Thompson, R. (2015). Comparing tissue compositions of within-individual mammographically high and low dense breast tissue. In CANCER RESEARCH Vol. 75 (pp. 2 pages). San Antonio, TX: AMER ASSOC CANCER RESEARCH.
2009	Hull, M. L., Johan, M., & Ingman, W. V. (2009). Host Site TGFB1 Deficiency Constrains Endometriosis-Like Lesion Development. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 101A). Glasgow, SCOTLAND: SAGE PUBLICATIONS INC.
2009	Ricciardelli, C., Frewin, K., Ingman, W., & Russell, D. L. (2009). Role of Adamts1 in mammary cancer growth and metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 26 (pp. 922). SPRINGER.
2008	Robertson, S., Jasper, M., Bromfield, J., Care, A., Nakamura, H., & Ingman, W. (2008). The role of macrophages in implantation and early pregnancy success. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 274-275). Kailua Kona, HI: SOC STUDY REPRODUCTION. DOI WoS2

Conference Items

Year	Citation
2020	Bernhardt, S. M., Dasari, P., Glynn, D. J., Woolford, L., Raymond, W., Moldenhauer, L. M., . . . Ingman, W. V. (2020). Menstrual cycling critically affects the Oncotype DX 21-gene signature: Implications for predictive biomarker assays in premenopausal women. Poster session presented at the meeting of CANCER RESEARCH. San Antonio, TX: AMER ASSOC CANCER RESEARCH. DOI WoS1
2018	Bernhardt, S., Townsend, A., Price, T., & Ingman, W. (2018). Hormonal modulation of breast cancer gene expression and implications for diagnosis and treatment of premenopausal women. Poster session presented at the meeting of CLINICAL ENDOCRINOLOGY. Perth, AUSTRALIA: WILEY.
2017	Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). Anticancer efficacy of the hypoxia-activated pro-drug evofosfamide in prcelinIcal osteosarcoma murine models. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD.
2017	Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). The hypoxia activated pro-drug evofosfamide exhibits tumour suppressive activity and synergy with chemotherapy against primary and metastatic breast cancers. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD.
2016	Huo, C. W., Chew, G., Waltham, M., Ingman, W., Brown, K., Timpson, P., . . . Britt, K. (2016). THE BIOLOGY UNDERLYING MAMMOGRAPHIC DENSITY AND PRECLINICAL MOUSE MODELS TO TEST NEW THERAPIES. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL.
2013	Johan, M. Z., Ingman, W. V., Robertson, S. A., & Hull, M. L. (2013). Activation Status of Macrophages in Lesions from a MacGreen/SCID Mouse Model of Endometriosis. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Orlando, FL: SAGE PUBLICATIONS INC.
2010	Care, A. S., Jasper, M. J., Ingman, W. V., & Robertson, S. A. (2010). Macrophages are essential for maintenance of corpus luteum function in early pregnancy. Poster session presented at the meeting of Meeting Abstracts, as published in Biology of Reproduction. Milwaukee, Wisconsin: Society for the Study of Reproduction.
2010	Ingman, W. V., Chua, A. C. L., Hodson, L. J., & Robertson, S. A. (2010). Novel roles for macrophages in epithelial cell turnover in the cycling adult mammary gland. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD. DOI
2010	Jasper, M. J., Care, A. S., Sullivan, B., Ingman, W. V., Aplin, J. D., & Robertson, S. A. (2010). Uterine epithelial cell fucosylated structures are regulated by macrophages during early pregnancy in mouse. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD. DOI
2009	Ingman, W. V., Chua, A. C. L., Clark, L. J., & Robertson, S. A. (2009). Key roles for macrophages in the proliferation, differentiation, and phagocytosis of epithetial cells in the mammary gland of cycling mice. Poster session presented at the meeting of Abstracts of the 42nd Annual Meeting of the Society for the Study of Reproduction, as published in Biology of Reproduction. Pittsburgh, PA: Society for the Study of Reproduction.

Date	Project Title	Investigators	Funding Body	Amount
2016 - 2017	Exploring the impact of menstrual cycling on personalised medicine for premenopausal breast cancer patients	W Ingman	The Hospital Research Foundation	100 000
2015 - 2016	Inflammation in mammographic density and breast cancer risk	A Evdokiou, W Ingman	The Hospital Research Foundation	110 000
2011 - 2014	Immune system determinants of breast cancer susceptibility	W Ingman	National Breast Cancer Foundation	600 000
2013 - 2014	A novel concept for parity-induced breast cancer protection	W Ingman	National Breast Cancer Foundation	199 997
2011 - 2012	Control of breast density and cancer risk by stromal-epithelial interactions	W Ingman	National Breast Cancer Foundation	199 772
2011 - 2013	TGFB1 is a pivotal regulator of endometriotic lesion development	L Hull, W Ingman	Australian National Health and Medical Research Council	423 786
2011	Understanding the inflammatory basis of mastitis	W Ingman	Channel 7 Children’s Research Foundation	70 000
2009 - 2011	Macrophages in developmental programming of reproductive health	W Ingman	Australian National Health and Medical Research Council	511 500
2011	Extracellular matrix – macrophage crosstalk in the mammary gland	W Ingman, Ricciardelli C, Russell D, Sharkey DJ	Robinson Institute	12 000
2003 - 2008	Macrophages in mammary gland development and disease	W Ingman	Australian National Health and Medical Research Council	368 000
2007	Establishing a mouse model to study the role of TGFbeta-regulated macrophages in reproductive biology	W Ingman	Research Centre for Reproductive Health	10 000
2006 - 2007	Physiological role of TGFbeta 1 in erectile dysfunction	W Ingman, Musgrave I, Robertson SA	University of Adelaide	25 000
2005 - 2006	Macrophage regulating cytokines in mammary gland development and disease	W Ingman, Robertson SA	University of Adelaide	17 000

Undergraduate degree teaching

2021-2022 Bachelor of Medicine and Surgery, University of Adelaide; Research and Critical Appraisal course, supervision of research project

2018-2021 Bachelor of Health Science; Reproductive Health Matters, University of Adelaide; Lecture and Workshop on lactation

2020-2022 Bachelor of Health Science; Precision Medicine II, University of Adelaide; Lecture on precision medicine in breast cancer

2014 Bachelor of Health Science; Physiology III, University of Adelaide; supervision of research project

2009-2017 Bachelor of Health Science, Comparative Reproductive Biology of Mammals III, University of Adelaide; lecture in mammary gland development, lactation, evolution of mammary gland and comparative biology of lactation in different mammals

2010-2012 Bachelor of Animal Science, Animal Reproduction and Development III, University of Adelaide; lecture on mammary gland development, lactation, comparative biology of lactation in different mammals and mammary gland diseases in livestock.

2002 Supervisor of 4th year research project, Bachelor of Medicine, University of Adelaide

2001 Supervisor for Structural Cell Biology III, Bachelor of Health Science, University of Adelaide

1998-2000 Bachelor of Medicine and Surgery, Introductory Medicine I and II, University of Adelaide; Tutor and Examiner

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2023	Principal Supervisor	Defining Male Breast Cancer: From the biological, clinical and patient perspective	Doctor of Philosophy	Doctorate	Full Time	Dr Steve Kinsey-Trotman
2022	Principal Supervisor	The role of TLR4 in mammographic density and breast cancer risk	Doctor of Philosophy	Doctorate	Full Time	Miss Hanieh Heydarlou
2022	Co-Supervisor	The Biology of Triple Negative Breast Cancer	Doctor of Philosophy	Doctorate	Full Time	Ms Sima Kianpour Rad
2021	Principal Supervisor	Mammographic density: optimising communication and clinical care	Doctor of Philosophy	Doctorate	Full Time	Mr Avisak Bhattacharjee

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2017 - 2021	Principal Supervisor	The Developmental Origins of Mammographic Density and Breast Cancer Risk	Doctor of Philosophy	Doctorate	Full Time	Miss Amita Gautam Ghadge
2016 - 2020	Principal Supervisor	The effect of menstrual cycling on genomic predictive biomarkers in premenopausal breast cancer	Doctor of Philosophy	Doctorate	Full Time	Miss Sarah Margaret Bernhardt
2016 - 2022	Principal Supervisor	DEVELOPMENT AND EVALUATION OF MOUSE MONOCLONAL ANTIBODIES AGAINST HUMAN C1Q	Doctor of Philosophy	Doctorate	Full Time	Mr Joseph Wrin
2015 - 2018	Principal Supervisor	Hormone and transcription factor regulation of cytokines in the mammary gland	Doctor of Philosophy	Doctorate	Full Time	Mr Vahid Atashgaran
2015 - 2020	Principal Supervisor	Immune Modulation of Mammographic Density and Breast Cancer Risk	Doctor of Philosophy	Doctorate	Full Time	Maddison Rose McKinnon Archer
2012 - 2015	Principal Supervisor	Cytokine-macrophage Regulatory Network in Mammary Gland Development and Tumourigenesis	Doctor of Philosophy	Doctorate	Full Time	Miss Xuan Sun
2011 - 2014	Co-Supervisor	The Effect of Macrophages on Fibroblast Activity and Lesion Development in Mouse Models of Endometriosis	Doctor of Philosophy	Doctorate	Full Time	Mr Mohammad Zahied Johan
2011 - 2017	Principal Supervisor	Effect of C1q Null Mutation on Mammary Gland Development and Breast Cancer Susceptibility	Doctor of Philosophy	Doctorate	Full Time	Miss Siti Mariam Noor Din
2009 - 2012	Co-Supervisor	The Role of Macrophages in Early Pregnancy Success	Doctor of Philosophy	Doctorate	Full Time	Dr Alison Care

Board Memberships

Date Role Board name Institution name Country
2008 - 2011 Council Society for Reproductive Biology - -
Committee Memberships

Date Role Committee Institution Country
2012 - 2015 Chair Basil Hetzel Institute Management Committee The Queen Elizabeth Hospital Australia
Editorial Boards

Date Role Editorial Board Name Institution Country
2015 - ongoing Associate Editor Frontiers in Endocrinology - -

Date	Role	Board name	Institution name	Country
2008 - 2011	Council	Society for Reproductive Biology	-	-

Date	Role	Committee	Institution	Country
2012 - 2015	Chair	Basil Hetzel Institute Management Committee	The Queen Elizabeth Hospital	Australia

Date	Role	Editorial Board Name	Institution	Country
2015 - ongoing	Associate Editor	Frontiers in Endocrinology	-	-

Position: Ext-Funded Research Fellow (D)
Phone: 82226141
Email: wendy.ingman@adelaide.edu.au
Campus: North Terrace
Building: QEH - Basil Hetzel Institute
Org Unit: Surgical Specialities

Associate Professor Wendy Ingman

Improving breast health throughout the life course

Breast Biology & Cancer Unit - 'prevention for the future'

Breast cancer prevention research

Improving breast cancer treatment decision-making

Lactation mastitis and breastfeeding research

Appointments

Awards and Achievements

Education

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

Board Memberships

Committee Memberships

Editorial Boards

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