Ext-Funded Research Fellow (D)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Wendy is a breast health expert and leads multi-disciplinary research that integrates biomedical, clinical and public health approaches. Her research interests span breast cancer, breastfeeding and breast development. Current research projects include identifying the impact of menstrual cycling on predictive breast cancer tests, development of a new technology for early breast cancer detection, defining the underlying biology of mammographic density as a breast cancer risk factor, and establishing a new paradigm for lactation mastitis.
Wendy provides commentary and professional education for the community and healthcare sectors on breast issues including breast cancer and breastfeeding. She is passionate about the importance of community education and advocates for women to be well-informed about how to take control of their own breast health. She has provided expert advice and education for a number of national organisations including BreastScreen Australia, the Australian Breastfeeding Association, and the Clinical Oncology Society of Australia. Wendy founded and currently leads a national alliance of breast cancer researchers called InforMD (visit www.informd.org.au for more information), who are highly active in public health policy and community awareness.
- My Research
- Grants and Funding
- Professional Activities
Ahead of her lecture at the GOLD Lactation Online Conference in 2021, Wendy spoke to Fiona Lang-Sharpe about what inspires her in her work, and why breast research is so important.
Improving breast health throughout the life course
The breast is a unique organ, because it goes through most of its development a long time after birth. For example, puberty is a really important phase in breast development, as is pregnancy. This development is key in enabling the breast to perform its critical function in producing milk to nurture a new baby, but it also affects the risk of breast cancer for a woman's entire life. We know that the breast is the most susceptible tissue in a woman's body for developing cancer, so it's very important to understand how it grows and functions. Our research focus is on studying how the breast functions and how disease states can develop in the breast, such as breast cancer and lactation mastitis, and how this information can be used to improve women's breast health for the life course.
Breast Biology & Cancer Unit - 'prevention for the future'
Wendy leads the Breast Biology & Cancer Unit, based at The Queen Elizabeth Hospital. The research focus is on understanding the underlying biology of breast function and risk of disease. The Unit works closely with a broad range of clinicians, communication experts and community groups so that new discoveries will translate into improved prevention, detection and treatment decision-making, with the ultimate goal to improve breast health outcomes. Research projects are available for Honours, Masters and PhD students.
Breast cancer prevention research
Breast cancer places an incredible burden on Australian women. Every year, around 20,000 Australian women are diagnosed with breast cancer alone - a disease that devastates people's lives and is often fatal. If we are to prevent breast cancer, we must better understand how the disease develops. This research studies the biological mechanisms of two different risk factors - breast density and menstrual cycling.
Why breast density matters in prevention and detection of breast cancer
Breast density (also known as mammographic density) is the percentage of white and bright regions on a mammogram. Breast density is not related to how breasts look or feel and can only be assessed by mammogram. High breast density is both an independent risk factor for breast cancer and masks cancers on a mammogram. Combined, these two distinct phenomena lead to increased incidence, delayed diagnosis, more aggressive tumours, and a 90% increased risk of breast cancer-associated death in women with high breast density. Learn more about breast density here.
Despite the difficulties breast density cause in the detection of breast cancer, there is exciting potential for breast density to become a widespread health assessment tool, used to identify the women most at risk of breast cancer in order to intervene early and reduce that risk. Our research is the first to demonstrate a causal role for immune system signalling in breast density and the associated cancer risk, opening the door for new approaches to reduce breast cancer risk through use of anti-inflammatory drugs in women with dense breasts. Find out more about this discovery in Wendy's ABC Health Report podcast with Dr Norman Swan.
Immune cells open a window of breast cancer risk each menstrual cycle
Menstrual cycling increases a woman's risk of breast cancer. For each year younger a girl starts menstruating (i.e. having a period each month), there is a 5% increased risk of breast cancer over her lifetime. Our research has focused on immune cells known as macrophages in the breast, and how the role of these cells changes because of fluctuations in hormones during different times of the month. We have discovered that while the immune cells have a role to play in the normal function of the breast, at certain stages in the menstrual cycle they may help to make the breast more susceptible to cancer. Learn more about this discovery here.
Improving breast cancer treatment decision-making
Gene expression profiling of breast cancer is a technology increasingly being adopted in the clinic as a precision medicine approach to tailor treatment to individual patients. However, an underappreciated factor in breast cancer diagnosis in young women is that oestrogen and progesterone fluctuate dramatically during the menstrual cycle, and these hormones are likely to affect gene expression. We have shown that the menstrual cycle can affect precision medicine which could in turn affect treatment decision-making.
Lactation mastitis and breastfeeding research
Lactation mastitis is an inflammatory breast disease affecting 1 of 5 Australian breastfeeding women. It causes pain, fever and low milk supply. The challenges posed by this disease lead many women to use supplementary formula, or cease breastfeeding altogether leaving their infants at increased risk of respiratory and gastrointestinal diseases as babies, and non-communicable diseases including heart disease, obesity, diabetes, cancer, allergies, asthma, mental illness and chronic lung, liver and renal diseases as both children and adults. Our research has suggested that macrophages play a role in development of this disease. We are now exploring revolutionary new concepts of how immune cells function in the breast, and how these cells affect breast disease development. Learn more about lactation mastitis in Wendy's podcast for the Australian Breastfeeding Association.
Date Position Institution name 2011 - ongoing Associate Professor University of Adelaide 2009 - 2010 Research Fellow University of Adelaide 2008 - 2008 Postdoctoral Research Officer University of Adelaide 2003 - 2008 CJ Martin Fellow University of Adelaide and Albert Einstein College of Medicine 2002 - 2003 Research Officer Adelaide University 1998 - 1998 Research Assistant Queen Elizabeth Hospital
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Award Award for Excellence in Reproductive Biology Research Society for Reproductive Biology Australia 2016 Award Women’s Research Excellence Awards University of Adelaide Australia 2012 Award SA Leading Light Award Finalist Australian Society for Medical Research 2011 Recognition Most Outstanding Research Paper published in 2011 University of Adelaide Australia 2010 Recognition Excellence in Research Supervision University of Adelaide Australia 2008 Award Best Presentation by Postdoctoral Fellow Network of Genes and Environment in Development Australia 2007 Award Most Outstanding Early Career Researcher University of Adelaide Australia 2007 Recognition Most Outstanding Research Paper published in 2007 University of Adelaide Australia 2005 Award Tall Poppy Science Award Australian Institute of Political Science 2003 Fellowship NHMRC CJ Martin Fellowship NHMRC Australia 2003 Scholarship World Academy of Arts and Science’s Emily Hartshorne Mudd Scholarship & C. Lalor Burdick Scholarship 2002 Award Young Investigator Award, finalist Women’s and Children’s Hospital 2001 Award Ross Wishart Award Australian Society for Medical Research Australia 2001 Award Find of National Science Week Australia 2001 Award Junior Scientist Award, 1st place Society for Reproductive Biology Australia 2001 Research Award Trainee Research Award, 2nd place Society for the Study of Reproduction Australia 1998 Award Australian Postgraduate Award 1997 Award Junior Scientist Award, finalist Australian Society for Reproductive Biology
Date Institution name Country Title 1998 - 2002 University of Adelaide Australia PhD 1993 - 1997 University of Adelaide Australia BSc
Year Citation 2015 Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., Ingman, W., Iasiello, M. P., . . . Evdokiou, A. (2015). Uncovering a new role for peroxidases in breast cancer development and metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 32 (pp. 227-228). SPRINGER. 2015 Huo, C. W., Huang, D., Chew, G. L., Hill, P., Ingman, W. V., Henderson, M., . . . Thompson, R. (2015). Comparing tissue compositions of within-individual mammographically high and low dense breast tissue. In CANCER RESEARCH Vol. 75 (pp. 2 pages). San Antonio, TX: AMER ASSOC CANCER RESEARCH. 2009 Hull, M. L., Johan, M., & Ingman, W. V. (2009). Host Site TGFB1 Deficiency Constrains Endometriosis-Like Lesion Development. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 101A). Glasgow, SCOTLAND: SAGE PUBLICATIONS INC. 2009 Ricciardelli, C., Frewin, K., Ingman, W., & Russell, D. L. (2009). Role of Adamts1 in mammary cancer growth and metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 26 (pp. 922). SPRINGER. 2008 Robertson, S., Jasper, M., Bromfield, J., Care, A., Nakamura, H., & Ingman, W. (2008). The role of macrophages in implantation and early pregnancy success. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 274-275). Kailua Kona, HI: SOC STUDY REPRODUCTION.
Year Citation 2020 Bernhardt, S. M., Dasari, P., Glynn, D. J., Woolford, L., Raymond, W., Moldenhauer, L. M., . . . Ingman, W. V. (2020). Menstrual cycling critically affects the Oncotype DX 21-gene signature: Implications for predictive biomarker assays in premenopausal women. Poster session presented at the meeting of CANCER RESEARCH. San Antonio, TX: AMER ASSOC CANCER RESEARCH.
2018 Bernhardt, S., Townsend, A., Price, T., & Ingman, W. (2018). Hormonal modulation of breast cancer gene expression and implications for diagnosis and treatment of premenopausal women. Poster session presented at the meeting of CLINICAL ENDOCRINOLOGY. Perth, AUSTRALIA: WILEY. 2017 Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). Anticancer efficacy of the hypoxia-activated pro-drug evofosfamide in prcelinIcal osteosarcoma murine models. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD. 2017 Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). The hypoxia activated pro-drug evofosfamide exhibits tumour suppressive activity and synergy with chemotherapy against primary and metastatic breast cancers. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD. 2016 Huo, C. W., Chew, G., Waltham, M., Ingman, W., Brown, K., Timpson, P., . . . Britt, K. (2016). THE BIOLOGY UNDERLYING MAMMOGRAPHIC DENSITY AND PRECLINICAL MOUSE MODELS TO TEST NEW THERAPIES. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY-BLACKWELL. 2013 Johan, M. Z., Ingman, W. V., Robertson, S. A., & Hull, M. L. (2013). Activation Status of Macrophages in Lesions from a MacGreen/SCID Mouse Model of Endometriosis. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Orlando, FL: SAGE PUBLICATIONS INC. 2010 Care, A. S., Jasper, M. J., Ingman, W. V., & Robertson, S. A. (2010). Macrophages are essential for maintenance of corpus luteum function in early pregnancy. Poster session presented at the meeting of Meeting Abstracts, as published in Biology of Reproduction. Milwaukee, Wisconsin: Society for the Study of Reproduction. 2010 Ingman, W. V., Chua, A. C. L., Hodson, L. J., & Robertson, S. A. (2010). Novel roles for macrophages in epithelial cell turnover in the cycling adult mammary gland. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD.
2010 Jasper, M. J., Care, A. S., Sullivan, B., Ingman, W. V., Aplin, J. D., & Robertson, S. A. (2010). Uterine epithelial cell fucosylated structures are regulated by macrophages during early pregnancy in mouse. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD.
2009 Ingman, W. V., Chua, A. C. L., Clark, L. J., & Robertson, S. A. (2009). Key roles for macrophages in the proliferation, differentiation, and phagocytosis of epithetial cells in the mammary gland of cycling mice. Poster session presented at the meeting of Abstracts of the 42nd Annual Meeting of the Society for the Study of Reproduction, as published in Biology of Reproduction. Pittsburgh, PA: Society for the Study of Reproduction.
|Date||Project Title||Investigators||Funding Body||Amount|
|2016 - 2017||Exploring the impact of menstrual cycling on personalised medicine for premenopausal breast cancer patients||W Ingman||The Hospital Research Foundation||100 000|
|2015 - 2016||Inflammation in mammographic density and breast cancer risk||A Evdokiou, W Ingman||The Hospital Research Foundation||110 000|
|2011 - 2014||Immune system determinants of breast cancer susceptibility||W Ingman||National Breast Cancer Foundation||600 000|
|2013 - 2014||A novel concept for parity-induced breast cancer protection||W Ingman||National Breast Cancer Foundation||199 997|
|2011 - 2012||Control of breast density and cancer risk by stromal-epithelial interactions||W Ingman||National Breast Cancer Foundation||199 772|
|2011 - 2013||TGFB1 is a pivotal regulator of endometriotic lesion development||L Hull, W Ingman||Australian National Health and Medical Research Council||423 786|
|2011||Understanding the inflammatory basis of mastitis||W Ingman||Channel 7 Children’s Research Foundation||70 000|
|2009 - 2011||Macrophages in developmental programming of reproductive health||W Ingman||Australian National Health and Medical Research Council||511 500|
|2011||Extracellular matrix – macrophage crosstalk in the mammary gland||W Ingman, Ricciardelli C, Russell D, Sharkey DJ||Robinson Institute||12 000|
|2003 - 2008||Macrophages in mammary gland development and disease||W Ingman||Australian National Health and Medical Research Council||368 000|
|2007||Establishing a mouse model to study the role of TGFbeta-regulated macrophages in reproductive biology||W Ingman||Research Centre for Reproductive Health||10 000|
|2006 - 2007||Physiological role of TGFbeta 1 in erectile dysfunction||W Ingman, Musgrave I, Robertson SA||University of Adelaide||25 000|
|2005 - 2006||Macrophage regulating cytokines in mammary gland development and disease||W Ingman, Robertson SA||University of Adelaide||17 000|
Undergraduate degree teaching
2021 Bachelor of Medicine and Surgery, University of Adelaide; Research and Critical Appraisal course, supervision of research project
2018-2021 Bachelor of Health Science; Reproductive Health Matters, University of Adelaide; Lecture and Workshop on lactation
2020, 2021 Bachelor of Health Science; Precision Medicine II, University of Adelaide; Lecture on precision medicine in breast cancer
2014 Bachelor of Health Science; Physiology III, University of Adelaide; supervision of research project
2009-2017 Bachelor of Health Science, Comparative Reproductive Biology of Mammals III, University of Adelaide; lecture in mammary gland development, lactation, evolution of mammary gland and comparative biology of lactation in different mammals
2010-2012 Bachelor of Animal Science, Animal Reproduction and Development III, University of Adelaide; lecture on mammary gland development, lactation, comparative biology of lactation in different mammals and mammary gland diseases in livestock.
2002 Supervisor of 4th year research project, Bachelor of Medicine, University of Adelaide
2001 Supervisor for Structural Cell Biology III, Bachelor of Health Science, University of Adelaide
1998-2000 Bachelor of Medicine and Surgery, Introductory Medicine I and II, University of Adelaide; Tutor and Examiner
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor The role of TLR4 in mammographic density and breast cancer risk Doctor of Philosophy Doctorate Full Time Miss Hanieh Heydarlou 2022 Co-Supervisor The Biology of Triple Negative Breast Cancer Doctor of Philosophy Doctorate Full Time Ms Sima Kianpour Rad 2021 Principal Supervisor Mammographic density: optimising communication and clinical care Doctor of Philosophy Doctorate Full Time Mr Avisak Bhattacharjee
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2021 Principal Supervisor The Developmental Origins of Mammographic Density and Breast Cancer Risk Doctor of Philosophy Doctorate Full Time Miss Amita Gautam Ghadge 2016 - 2020 Principal Supervisor The effect of menstrual cycling on genomic predictive biomarkers in premenopausal breast cancer Doctor of Philosophy Doctorate Full Time Miss Sarah Margaret Bernhardt 2016 - 2022 Principal Supervisor DEVELOPMENT AND EVALUATION OF MOUSE MONOCLONAL ANTIBODIES AGAINST HUMAN C1Q Doctor of Philosophy Doctorate Full Time Mr Joseph Wrin 2015 - 2018 Principal Supervisor Hormone and transcription factor regulation of cytokines in the mammary gland Doctor of Philosophy Doctorate Full Time Mr Vahid Atashgaran 2015 - 2020 Principal Supervisor Immune Modulation of Mammographic Density and Breast Cancer Risk Doctor of Philosophy Doctorate Full Time Maddison Rose McKinnon Archer 2012 - 2015 Principal Supervisor Cytokine-macrophage Regulatory Network in Mammary Gland Development and Tumourigenesis Doctor of Philosophy Doctorate Full Time Miss Xuan Sun 2011 - 2014 Co-Supervisor The Effect of Macrophages on Fibroblast Activity and Lesion Development in Mouse Models of Endometriosis Doctor of Philosophy Doctorate Full Time Mr Mohammad Zahied Johan 2011 - 2017 Principal Supervisor Effect of C1q Null Mutation on Mammary Gland Development and Breast Cancer Susceptibility Doctor of Philosophy Doctorate Full Time Miss Siti Mariam Noor Din 2009 - 2012 Co-Supervisor The Role of Macrophages in Early Pregnancy Success Doctor of Philosophy Doctorate Full Time Dr Alison Care
Date Role Board name Institution name Country 2008 - 2011 Council Society for Reproductive Biology
Date Role Committee Institution Country 2012 - 2015 Chair Basil Hetzel Institute Management Committee The Queen Elizabeth Hospital Australia
Date Role Editorial Board Name Institution Country 2015 - ongoing Associate Editor Frontiers in Endocrinology
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