Dr Alison Care

Alison Care
NHMRC CJ Martin Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr. Alison Care is an NHMRC CJ Martin Research Fellow at the Robinson Research Institute. Alison completed a Bachelor of Medical and Pharmaceutical Biotechnology with Honours at the University of South Australia in 2004. She subsequently completed her PhD with Professor Sarah Robertson at the University of Adelaide, where she investigated the role of the macrophage in early pregnancy success.

Following this, Alison moved to Edmonton in Canada for a period of 5 years, where she took a position as a postdoctoral fellow at the University of Alberta, under the supervision of Dr. Sandra Davidge. Here, Alison was funded by competitive Canadian fellowships from The Heart and Stroke Foundation of Canada and Alberta-Innovates Health Solutions. Alison developed high-level techniques and expertise in vascular function research. She began to investigate the cause of pregnancy complications and the long term health impact these complications can have for the mother and her offspring.
Alison then received the prestigious CJ Martin postdoctoral fellowship from the National Health and Medical Research Council of Australia. She has since returned to Australia, where she is currently investigating the pathophysiological mechanisms underpinning pregnancy complications.

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Dr Alison Care

Dr. Alison Care is an NHMRC CJ Martin Research Fellow at the Robinson Research Institute. Alison completed a Bachelor of Medical and Pharmaceutical Biotechnology with Honours at the University of South Australia in 2004. She subsequently completed her PhD with Professor Sarah Robertson at the University of Adelaide, where she investigated the role of the macrophage in early pregnancy success.

Following this, Alison moved to Edmonton in Canada for a period of 5 years, where she took a position as a postdoctoral fellow at the University of Alberta, under the supervision of Dr. Sandra Davidge. Here, Alison was funded by competitive Canadian fellowships from The Heart and Stroke Foundation of Canada and Alberta-Innovates Health Solutions. Alison developed high-level techniques and expertise in vascular function research. She began to investigate the cause of pregnancy complications and the long term health impact these complications can have for the mother and her offspring.
Alison then received the prestigious CJ Martin postdoctoral fellowship from the National Health and Medical Research Council of Australia. She has since returned to Australia, where she is currently investigating the pathophysiological mechanisms underpinning pregnancy complications.

My Research

My research in Vascular Physiology and Immunology of pregnancy investigates:

Maternal immune regulation of vascular adaptations during pregnancy, with a particular focus on uterine artery function and placental development

The effects of a complicated pregnancy on the long-term cardiovascular health of offspring (Developmental Origins of Health and Disease), as well as the impact on maternal health post-partum

Appointments

Date Position Institution name
2015 - 2018 NHMRC CJ Martin Fellow University of Adelaide
2012 - 2016 Postdoctoral Research Fellow University of Alberta

Awards and Achievements

Date Type Title Institution Name Amount
2017 Nomination for the University of Alberta Award for Outstanding Mentorship in Undergraduate Research University of Alberta
2016 MedStar Award for best research publication in the Faculty of Medicine and Dentistry University of Alberta
2014 Institute of Human Development, Child and Youth Health, Travel Award, National Competition Canadian Institute of Health Research (CIHR
2014 Women and Children’s Health Research Institute Travel Award The University of Alberta
2014 Winner, Poster Presentation Society for Gynecologic Investigation
2013 1st Place Oral Presentation, Postdoctoral Fellow category Women and Children’s Research Institute Research Day
2013 Western Perinatal Research Meeting (Best Poster Presentation)
2013 Women and Children’s Health Research Institute Research Day

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review

Education

Date Institution name Country Title
University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechnology with Honours
University of Adelaide Australia Doctor of Philosophy

Postgraduate Training

Date Title Institution Country
Graduate Certificate in Science and Technology Commercialisation University of Adelaide Australia

Journals

Date Citation
2017 Morton,JS, Care,AS, Davidge,ST, 2017, Mechanisms of Uterine Artery Dysfunction in Pregnancy Complications, Journal of Cardiovascular Pharmacology, -
2016 Care,A, Sung,M, Panahi,S, Gragasin,F, Dyck,J, Davidge,S, Bourque,S, 2016, Perinatal resveratrol supplementation to spontaneously hypertensive rat dams mitigates the development of hypertension in adult offspring, Hypertension, 67, 5, 1038-1044 10.1161/HYPERTENSIONAHA.115.06793
2015 Care,A, Bourque,S, Morton,J, Hjartarson,E, Davidge,S, 2015, Effect of advanced maternal age on pregnancy outcomes and vascular function in the rat, Hypertension, 65, 6, 1324-1330 10.1161/HYPERTENSIONAHA.115.05167
2014 Bromfield,J, Schjenken,J, Chin,P, Care,A, Jasper,M, Robertson,S, 2014, Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring, PNAS, 111, 6, 2200-2205 10.1073/pnas.1305609111
2014 Care,A, Ingman,W, Moldenhauer,L, Jasper,M, Robertson,S, 2014, Ovarian steroid hormone-regulated uterine remodeling occurs independently of macrophages in mice, Biology of Reproduction, 91, 3, 60-1-60-12 10.1095/biolreprod.113.116509
2013 Care,A, Diener,K, Jasper,M, Brown,H, Ingman,W, Robertson,S, 2013, Macrophages regulate corpus luteum development during embryo implantation in mice, Journal of Clinical Investigation, 123, 8, 3472-3487 10.1172/JCI60561
2011 Jasper,M, Care,A, Sullivan,B, Ingman,W, Aplin,J, Robertson,S, 2011, Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy, Biology of Reproduction, 84, 1, 179-188 10.1095/biolreprod.110.085399
2010 Care,A, Jasper,M, Ingman,W, Robertson,S, 2010, An essential role for macrophages in corpus luteum function and early pregnancy maintenance, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 86, 1, 55-55 10.1016/j.jri.2010.06.115
2010 Robertson,S, Christiaens,I, Dorian,C, Zaragoza,D, Care,A, Banks,A, Olson,D, 2010, Interleukin-6 is an essential determinant of on-time parturition in the mouse, Endocrinology, 151, 8, 3996-4006 10.1210/en.2010-0063
2009 Robertson,S, Guerin,L, Bromfield,J, Branson,K, Ahlstrom,A, Care,A, 2009, Seminal fluid drives expansion of the CD4(+)CD25(+) T regulatory cell pool and induces tolerance to paternal alloantigens in mice, Biology of Reproduction, 80, 5, 1036-1045 10.1095/biolreprod.108.074658
2007 Robertson,S, Care,A, Skinner,R, 2007, Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice, Biology of Reproduction, 76, 5, 738-748 10.1095/biolreprod.106.056143
2006 Robertson,S, Skinner,R, Care,A, 2006, Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice, Journal of Immunology, 177, 7, 4888-4896 10.4049/jimmunol.177.7.4888

Book Chapters

Date Citation
2014 Robertson,SA, Sharkey,DJ, Schjenken,JE, Care,AS, Moldenhauer,LM, 2014, Pathways for activating implantation tolerance in early pregnancy., Bentham Science Publishers, pp. 1835-1874 10.1016/B978-0-12-397175-3.00041-7

Conference Papers

Date Citation
2016 Care,AS, Bourque,SL, Hjartarson,EP, Robertson,SA, Davidge,ST, 2016, Effect of Regulatory T Cell Depletion on Uterine Artery Function in the Mouse., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Montreal, CANADA
2016 Bourque,SL, Care,AS, Sung,M, Dyck,JR, Davidge,ST, 2016, Effects of Maternal Resveratrol Treatment on Blood Pressure and Vascular Function in Adult Spontaneously Hypertensive Rat Offspring., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Montreal, CANADA
2016 Morton,JS, Care,AS, Cooke,C-LM, Kirschenman,R, Davidge,ST, 2016, Altered Vascular Endothelial Function Three Months Postpartum in Dams of Advanced Maternal Age, 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Montreal, CANADA
2016 Cooke,C-LM, Care,AS, Morton,JS, Kirschenman,RD, Davidge,ST, 2016, Endothelium-Dependent Vascular Function Is Impaired in Male Offspring from Aged Dams., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Montreal, CANADA
2008 Robertson,S, Jasper,M, Bromfield,J, Care,A, Nakamura,H, Ingman,W, 2008, The role of macrophages in implantation and early pregnancy success, World Congress on Reproductive Biology, Kailua Kona, HI 10.1093/biolreprod/78.s1.274c

Conference Items

Date Citation
2015 Cooke,C-LM, Care,AS, Morton,JS, Shah,A, Reyes,LM, Davidge,ST, 2015, Increased Susceptibility To Cardiovascular Disease in Offspring Born From Dams of Advanced Maternal Age
2015 Care,AS, Bourque,SL, Davidge,ST, 2015, Assessment of the Time-Course of Pregnancy Loss in a Rat Model of Advanced Maternal Age
2014 Bourque,SL, Care,AS, Davidge,ST, 2014, Perinatal Iron Deficiency Increases Susceptibility to Diet-Induced Obesity: Effects of Prenatal Resveratrol Treatment.
2014 Care,AS, Bourque,SL, Davidge,ST, 2014, Effect of Advanced Maternal Age on Pregnancy Outcomes in the Rat
2010 Jasper,M, Care,A, Sullivan,B, Ingman,W, Aplin,J, Robertson,S, 2010, Uterine epithelial cell fucosylated structures are regulated by macrophages during early pregnancy in mouse, 11th International Congress of Reproductive Immunology, Palm Grove, AUSTRALIA 10.1016/j.jri.2010.06.071
2010 Care,AS, Jasper,MJ, Ingman,WV, Robertson,SA, 2010, Macrophages are essential for maintenance of corpus luteum function in early pregnancy, 43rd Annual Meeting of the Society for the Study of Reproduction, Milwaukee, Wisconsin

Working Paper

Date Citation
2016 Care,AS; 2016; Mechanisms of Uterine Artery Dysfunction in Pregnancy Complications
2016 Care,AS; 2016; Adult Offspring Born to Mothers of Advanced Maternal Age Have Impaired Recovery Following Ischemia/Reperfusion Injury and Vascular Dysfunction
Grants and Funding
2015-2017 Inflammatory cytokines as causal agents in peri-conception programming of offspring health/ APP1079150 CI-A Robertson SA, other CI: Thompson JG and Brown H, AI- Care AS NHMRC $585,276
2013-2017 Effects of Advanced Maternal Age on Vascular Adaptations in Pregnancy and Subsequent Maternal and Offspring Cardiovascular Health. Care AS is a co-investigator with CI-A Davidge, ST. Canadian Institutes of Health and Research (CIHR) CAD$563,708
Jan 2015-present CJ Martin Early Career Fellowship                                                  NHMRC $330,948
Jul 2013-Dec 2014 Postdoctoral Fellowship     Heart and Stroke Foundation Canada (HSFC) CAD $83,000  
Jan 2013- Dec 2014 Postdoctoral Fellowship   Alberta Innovates Health Solutions (AIHS) CAD $165,000
Mar 2007-Mar 2011 Postgraduate Scholarship       NHMRC    $79,209
May 2011-Jun 2011 Frontiers in Reproduction Scholar – participating in 6 week training course at MLB, USA.                        Marine Biological Laboratory, Burroughs Wellcome Fund  USD $6,500

                         

Teaching

Teaching Assistant, University of South Australia, Australia

Teaching and laboratory demonstrations for undergraduate 1st year Physiology 100 students.

Supervision

University of Alberta, co-upervised two 4th year undergraduate (PHYS 467) students

University of Alberta, Supervised a summer scholar

Memberships

Date Role Membership Country
2017 Member Healthy Development Adelaide Australia
2012 Member Society for Reproductive Investigation
2012 Member Women and Children’s Health Research Institute Canada
2011 Member Society for the Study of Reproduction
2007 Member Society for Reproductive Biology, Australia

Committee Memberships

Date Role Committee Institution Country
2014 - 2016 Vice-President University of Alberta Postdoctoral Fellows Association, VP Communication
Position
NHMRC CJ Martin Fellow
Phone
83131504
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS6071.12
Org Unit
Paediatrics and Reproductive Health

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