Professor Mark Hutchinson

Director - Centre for Nanoscale BioPhotonics

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Mark Hutchinson is an ARC Future fellow and Professor within the Adelaide Medical School, the Director of the ARC Centre of Excellence for Nanoscale BioPhotonics. Mark is also President of Science and Technology Australia, the peak body in Australia that represents 110,000 scientists.

The team he leads is world-leading, developing innovative technologies that allow for the early diagnosis and treatment of neurological diseases, including pain. Professor Hutchinson’s research explores the “other brain” or the other 90% of cells in the brain and spinal cord. These immune-like cells are termed glia. Mark’s research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments. He has pioneered research which has led to the discovery of novel drug activity at innate immune receptors. His work has enabled the translation of compounds at the lab bench to clinical agents used at the bedside.

In his role as Director of the CNBP he is responsible for the research program of the ARC Centre of Excellence with $50M of funding headquartered at The University of Adelaide, with nodes at Macquarie University and UNSW, Sydney, the RMIT, Melbourne and Griffith University Qld. The CNBP is partnered with universities and companies in Europe, the US and China, as well as other Australian institutions. Prof Hutchinson’s work with the CNBP is to "Discover new approaches to measure nano-scale dynamic phenomena in living systems” and allow the first minimally invasive realtime visualisations of the “other brain”.

Mark serves as a founding member of the Operating in Contaminated Environments Advisory Council for the DSTG CBRN STaRShot, is a founding member of the executive of the Animal Welfare Collaborative (TAWC), is the Chair of the Australian Pain Solutions Research Alliance, the co-chair of the Safeguarding Australia through Biotechnology Response and Engagement (SABRE) Alliance, a Ministerial appointment to the Australian Research Council CEO Advisory Council, and one of three eminent academics reviewing the ARC Federal Legislation.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

Mark’s research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments.

Mark has published over 240 papers in journals and refereed conference proceedings.

The CNBP is an ARC Centre of Excellence with $50M of funding committed for 7 years, headquartered at The University of Adelaide, with nodes at Macquarie University, Sydney; the RMIT, Melbourne; and Griffith University, the Gold Coast. We are partnered with universities and companies in Europe, the US and China, as well as other Australian institutions.

The CNBP has a mission to "Discover new approaches to measure nano-scale dynamic phenomena in living systems".

I have several openings for research projects within my team for PhD students

Project 1
Title: Cell-based biomarker of persistent pain in livestock
Description: This project will translate a human biomarker of pain into the livestock setting to predict the chronic pain of animal husbandry practices.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2023
Special requirements: surgical skills, cell culture experience and some bioinformatics

Project 2
Title: Transcriptome biomarker of persistent pain in livestock
Description: This project will translate a human biomarker of pain into the livestock setting to predict the chronic pain of animal husbandry practices.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2023
Special requirements: surgical skills, bioinformatics and molecular techniques.

Project 3
Title: Modeling persistent pain in livestock
Description: This project will translate a human model of neuroimmune pain into the livestock setting to better predict the consequences of chronic pain in livestock and allow the development of novel pain therapies.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2023
Special requirements: surgical skills, animal handling experience and molecular techniques.

Project 4
Title: Drug discovery for novel treatments of persistent pain in livestock
Description: This project will translate neuroimmune pain targeted treatments into the livestock setting to better treat chronic pain in livestock and allow the development of deployable pain therapies.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2023
Special requirements: surgical skills, animal handling experience and molecular pharmacology techniques.

Appointments

Date	Position	Institution name
2014 - ongoing	Director	Australian Research Council Centre of Excellence for Nanoscale BioPhotonics
2014 - ongoing	Professor	University of Adelaide
2013 - 2014	Associate Professor	University of Adelaide
2011 - 2012	ARC Research Fellow	University of Adelaide
2009 - 2010	NHMRC CJ Martin Research Fellow	University of Adelaide
2005 - 2008	Postdoc Research Fellow	University of Colorado Boulder

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2015	Award	The James McWha Award of Excellence	University of Adelaide	Australia	-
2014	Award	Brain Behavior & Immunity Reviewer of the Year	Elsevier	Australia	-
2013	Nomination	South Australian Leading Light Finalist	Australian Society for Medical Research (ASMR)	Australia	-
2013	Award	Robert Ader New Investigator	Psychoneuroimmunology Research Society	-	-
2012	Nomination	Young Researcher Award Finalist	Scopus	-	-
2012	Award	Tess Cramond Lecturer	Australian Pain Society	Australia	-
2011	Award	College on Problems of Drug Abuse Early Career Prize	-	-	-
2010	Award	South Australian Tall Poppy Science Awardee	-	Australia	-
2009	Award	Denis Wade Johnson & Johnson New Investigators	The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)	-	-
2007	Award	National Institute for Drug Addiction Young Investigator	National Institute for Drug Addiction	Australia	-
2006	Award	Society on Neuroimmune Pharmacology Travel	Society on Neuroimmune Pharmacology	-	-
2005	Award	Oral Presentation Finalist Winner	Front Range Neuroscience Group	-	-
2005	Fellowship	American Australian Association Merck Company Foundation Fellow	American Australian Association Merck Company Foundation	-	-
2005	Nomination	Chapter travel award	Front Range Neuroscience Group	-	-
2005	Award	Chapter oral presentation winner	Front Range Neuroscience Group	-	-
2005	Award	Recipient of a British Council Travel	British Council	-	-
2004	Award	Australian FreshScience Winner	Fresh Science	Australia	-

Education

Date	Institution name	Country	Title
2004	University of Adelaide	Australia	PhD in Medicine
1999	University of Adelaide	Australia	BSc (First class Honours) in Pharmacology
1998	University of Adelaide	Australia	BSc

Research Interests

Basic Pharmacology Clinical Pharmacology and Therapeutics Immunology Innate Immunity Nanomaterials Nanophotonics Nanoscience & Nanotechnology Nanotechnology Neurosciences Pharmacogenomics Pharmacology and Pharmaceutical Sciences Photodetectors, Optical Sensors and Solar Cells Neuroscience, Behaviour and Brain Health Surgical and Health Systems Innovation Pregnancy and Birth Early Origins of Health Immunology and Infection Translational Health Outcomes Innovative Therapeutics

Journals

Year	Citation
2023	Moseley, G. L., Pearson, N., Reezigt, R., Madden, V. J., Hutchinson, M. R., Dunbar, M., . . . Wand, B. M. (2023). Considering Precision and Utility When we Talk About Pain. Comment on Cohen et al. The Journal of Pain, 24(1), 178-181. DOI Scopus2 WoS1 Europe PMC1
2023	Ryan, M., Tuke, J., Hutchinson, M. R., & Spencer, S. J. (2023). Gender-specific effects of COVID-19 lockdowns on scientific publishing productivity: Impact and resilience. Social Science and Medicine, 320, 115761-1-115761-9. DOI Scopus1 WoS1
2023	Mustafa, S., Bajic, J. E., Barry, B., Evans, S., Siemens, K. R., Hutchinson, M. R., & Grace, P. M. (2023). One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology.. Neuropharmacology, 228, 109459. DOI Scopus2 WoS2
2023	Chen, K. K., Hutchinson, M. R., Rolan, P., & de Zoete, R. M. J. (2023). Effect of exercise on chronic neck pain and central sensitization: A protocol for a randomized crossover trial. Experimental Physiology, 108(5), 672-682. DOI
2023	Moh, E. S. X., Dalal, S., Hutchinson, M. R., & Packer, N. H. (2023). Mouse brain glycomics – Insights from exploring the Allen Brain Atlas and the implications for the neuroimmune brain. Brain, Behavior, and Immunity, 113, 83-90. DOI
2023	Hill-Yardin, E. L., Hutchinson, M. R., Laycock, R., & Spencer, S. J. (2023). A Chat(GPT) about the future of scientific publishing. Brain, Behavior, and Immunity, 110, 152-154. DOI Scopus24 Europe PMC10
2022	Madden, V. J., Msolo, N., Mqadi, L., Lesosky, M., Bedwell, G. J., Hutchinson, M. R., . . . Joska, J. A. (2022). Study protocol: an observational study of distress, immune function and persistent pain in HIV. BMJ Open, 12(6), e059723-1-e059723-10. DOI
2022	Johnston, C. H., Whittaker, A. L., Franklin, S. H., & Hutchinson, M. R. (2022). The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals. Frontiers in Neuroscience, 16, 1-16. DOI Scopus2 WoS2 Europe PMC2
2022	Gilron, I., Xiao, M. Z. X., Balanaser, M., Carley, M., Ghasemlou, N., Salter, M. W., . . . Ross-White, A. (2022). Glial-modulating agents for the treatment of pain: protocol for a systematic review. BMJ Open, 12(4), 5 pages. DOI
2022	Moh, E. S. X., Nishtala, K., Iqbal, S., Staikopoulos, V., Kapur, D., Hutchinson, M. R., & Packer, N. H. (2022). Long-term intrathecal administration of morphine vs. baclofen: differences in CSF glycoconjugate profiles using multiglycomics. Glycobiology, 32(1), 50-59. DOI Scopus4 WoS2
2022	Thomas, J. H. L., Lui, L., Abell, A., Tieu, W., Somogyi, A. A., Bajic, J. E., & Hutchinson, M. R. (2022). Toll-Like Receptors change morphine-induced antinociception, tolerance and dependence: studies using male and female TLR and Signalling gene KO mice. Brain, Behavior, and Immunity, 102, 71-85. DOI Scopus7 WoS7 Europe PMC4
2022	Bajic, J., Howarth, G., Mashtoub, S., Whittaker, A., Bobrovskaya, L., & Hutchinson, M. R. (2022). Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats. Journal of Neuroscience Research, 100(1), 237-250. DOI Scopus3 WoS3 Europe PMC1
2022	Staikopoulos, V., Zhang, X., Pullen, B. P., Reineck, P., Vidanapathirana, A. K., Lee, S. M., . . . Abell, A. D. (2022). Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo. Sensors and Diagnostics, 1(2), 280-293. DOI
2021	Zhang, T., Zhang, X., Lin, C., Wu, S., Wang, F., Wang, H., . . . Wang, X. (2021). Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood–brain barrier leakage in mice. Journal of Neurochemistry, 157(3), 611-623. DOI Scopus14 WoS10 Europe PMC6
2021	Evans, S. F., Kwok, Y., Solterbeck, A., Pyragius, C., Hull, M. L., Hutchinson, M. R., & Rolan, P. (2021). The relationship between androgens and days per month of period pain, pelvic pain, headache, and TLR4 responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhoea. Journal of Pain Research, 14, 585-599. DOI Scopus6 WoS6 Europe PMC5
2021	Li, H., Peng, Y., Lin, C., Zhang, X., Zhang, T., Wang, Y., . . . Wang, X. (2021). Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling. The Innovation, 2(2), 100111-1-100111-8. DOI Scopus9 Europe PMC5
2021	Marsh, L., Hutchinson, M., McLaughlan, C., Musolino, S., Hebart, M. L., Terry, R., . . . Whittaker, A. (2021). Evaluation of miRNA as biomarkers of emotional valence in pigs. Animals, 7(7), 1-19. DOI Scopus2 Europe PMC1
2021	Lin, C., Wang, H., Zhang, M., Mustafa, S., Wang, Y., Li, H., . . . Wang, X. (2021). TLR4 biased small molecule modulators. Pharmacology and Therapeutics, 228, 107918-1-107918-12. DOI Scopus16 WoS15 Europe PMC11
2021	Williams, B., Lees, F., Tsangari, E., Hutchinson, M. R., Perilli, E., & Crotti, T. N. (2021). Effects of mild and moderate monoclonal antibody dose on inflammation, bone loss, and activation of the central nervous system in a female collagen antibody-induced arthritis mouse model. Journal of Histochemistry and Cytochemistry, 69(8), 511-522. DOI Scopus1 WoS1
2021	Arman, A., & Hutchinson, M. R. (2021). Intrathecal implantation surgical considerations in rodents; a review. Journal of Neuroscience Methods, 363, 109327-1-109327-6. DOI Scopus1
2021	Gosnell, M. E., Staikopoulos, V., Anwer, A. G., Mahbub, S. B., Hutchinson, M. R., Mustafa, S., & Goldys, E. M. (2021). Autofluorescent imprint of chronic constriction nerve injury identified by deep learning. Neurobiology of Disease, 160, 105528-1-105528-11. DOI Scopus1 WoS1
2021	George, R., Semendric, I., Hutchinson, M., & Whittaker, A. (2021). Neuroimmune reactivity marker expression in rodent models of chemotherapy-induced cognitive impairment: a systematic scoping review. Brain, Behavior, and Immunity, 94, 392-409. DOI Scopus10 WoS9 Europe PMC5
2021	Staikopoulos, V., Qiao, S., Liu, J., Song, X., Yang, X., Luo, Q., . . . Zhang, Z. (2021). Graded peripheral nerve injury creates mechanical allodynia proportional to the progression and severity of microglial activity within the spinal cord of male mice. Brain, Behavior, and Immunity, 91, 568-577. DOI Scopus3 WoS3 Europe PMC2
2021	Grace, P. M., Tawfik, V. L., Svensson, C. I., Burton, M. D., Loggia, M. L., & Hutchinson, M. R. (2021). The neuroimmunology of chronic pain: from rodents to humans. The Journal of Neuroscience, 41(5), 855-865. DOI Scopus60 WoS55 Europe PMC37
2021	Ribarovska, A. K., Hutchinson, M. R., Pittman, Q. J., Pariante, C., & Spencer, S. J. (2021). Gender inequality in publishing during the COVID-19 pandemic. Brain, Behavior, and Immunity, 91, 1-3. DOI Scopus45 WoS38 Europe PMC25
2021	Miller, T. L., Jones, G. L., Hutchinson, M., Vyas, D., & Borchers, J. (2021). Evolving Expectations of the Orthopedic Team Physician: Managing the Sidelines and Landmines. Current sports medicine reports, 20(10), 553-561. DOI Scopus1 Europe PMC1
2021	Evans, S. F., Hull, M. L., Hutchinson, M. R., & Rolan, P. E. (2021). Androgens, Endometriosis and Pain.. Frontiers in reproductive health, 3, 7 pages. DOI Scopus6 Europe PMC2
2020	Doyle, T. M., Hutchinson, M. R., Braden, K., Janes, K., Staikopoulos, V., Chen, Z., . . . Salvemini, D. (2020). Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents. Journal of Neuroinflammation, 17(1), 8 pages. DOI Scopus1 WoS1 Europe PMC1
2020	Zabolocki, M., McCormack, K., van den Hurk, M., Milky, B., Shoubridge, A. P., Adams, R., . . . Bardy, C. (2020). BrainPhys neuronal medium optimized for imaging and optogenetics in vitro. Nature Communications, 11(1), 1-19. DOI Scopus14 WoS13 Europe PMC11
2020	Doyle, T. M., Largent-Milnes, T. M., Chen, Z., Staikopoulos, V., Esposito, E., Delgarno, R., . . . Salvemini, D. (2020). Chronic morphine-induced changes in signaling at the A3 adenosine receptor contribute to morphine-induced hyperalgesia, tolerance and withdrawal. The Journal of pharmacology and experimental therapeutics, 374(2), 331-341. DOI Scopus24 WoS21 Europe PMC20
2020	Frank, M. G., Baratta, M. V., Zhang, K., Fallon, I. P., Pearson, M. A., Liu, G., . . . Maier, S. F. (2020). Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus. Brain, Behavior, and Immunity, 90, 70-80. DOI Scopus6 WoS4 Europe PMC4
2020	Evans, S. F., Kwok, Y. H., Solterbeck, A., Liu, J., Hutchinson, M. R., Hull, M. L., & Rolan, P. E. (2020). Toll-like receptor responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhea. Journal of Pain Research, 13, 503-516. DOI Scopus6 WoS5 Europe PMC4
2020	Williams, B., Lees, F., Tsangari, H., Hutchinson, M. R., Perilli, E., & Crotti, T. N. (2020). Assessing the effects of parthenolide on inflammation, bone loss, and glial cells within a collagen antibody-Induced arthritis mouse model. Mediators Inflamm, 2020, 6245798. DOI Scopus8 WoS7 Europe PMC5
2020	Borrachero-Conejo, A. I., Adams, W. R., Saracino, E., Mola, M. G., Wang, M., Posati, T., . . . Benfenati, V. (2020). Stimulation of water and calcium dynamics in astrocytes with pulsed infrared light.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6539-6553. DOI Scopus17 WoS15 Europe PMC6
2020	Chia, J. S. M., Izham, N. A. M., Farouk, A. A. O., Sulaiman, M. R., Mustafa, S., Hutchinson, M. R., & Perimal, E. K. (2020). Zerumbone Modulates α<inf>2A</inf>-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models. Frontiers in Pharmacology, 11, 92. DOI Scopus17 WoS14 Europe PMC6
2020	Wang, Y., Zhang, S., Li, H., Wang, H., Zhang, T., Hutchinson, M. R., . . . Wang, X. (2020). Small-molecule modulators of toll-like receptors. Accounts of Chemical Research, 53(3), 1046-1055. DOI Scopus95 WoS91 Europe PMC55
2020	Arman, A., Deng, F., Goldys, E. M., Liu, G., & Hutchinson, M. R. (2020). In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain. Brain, Behavior, and Immunity, 88, 442-450. DOI Scopus8 WoS8 Europe PMC5
2020	Robertson, S. A., Hutchinson, M. R., Rice, K. C., Chin, P. -Y., Moldenhauer, L. M., Stark, M. J., . . . Keelan, J. A. (2020). Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury. Clinical and Translational Immunology, 9(4), e1121-1-e1121-19. DOI Scopus24 WoS19 Europe PMC15
2020	Kelley, K. W., Peng, Y. P., Liu, Q., Chang, H. C., Spencer, S. J., Hutchinson, M. R., & Shimada, A. (2020). Psychoneuroimmunology goes East: Development of the PNIRSChina affiliate and its expansion into PNIRSAsia-Pacific. Brain, Behavior, and Immunity, 88, 75-87. DOI Scopus6 WoS1 Europe PMC4
2020	Hutchinson, M. R. (2020). Science convergence applied to psychoneuroimmunology: the future of measurement and imaging. Brain, Behavior, and Immunity, 88, 262-269. DOI Scopus1
2020	Deng, F., Arman, A., Goldys, E. M., Hutchinson, M. R., & Liu, G. (2020). A Method for in Vivo Quantification of Cytokine IL-1β in the Rat Intrathecal Space. ACS Applied Bio Materials, 3(1), 539-546. DOI Scopus7 Europe PMC2
2020	Wahid, H. H., Chin, P. Y., Sharkey, D. J., Diener, K. R., Hutchinson, M. R., Rice, K. C., . . . Robertson, S. A. (2020). Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. American Journal of Pathology, 190(5), 1030-1045. DOI Scopus13 WoS12 Europe PMC9
2020	Khalid, A., Peng, L., Arman, A., Warren-Smith, S. C., Schartner, E. P., Sylvia, G. M., . . . Li, J. (2020). Silk: a bio-derived coating for optical fiber sensing applications. Sensors and Actuators B: Chemical, 311, 127864-1-127864-8. DOI Scopus21 WoS16
2020	Liddicoat, C., Sydnor, H., Cando-Dumancela, C., Dresken, R., Liu, J., Gellie, N., . . . Breed, M. F. (2020). Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice. Science of the Total Environment, 701, 1-11. DOI Scopus76 WoS71 Europe PMC29
2020	Iqbal, S., Parker, L. M., Everest-Dass, A., Moh, E. S. X., Sayyadi, N., Hutchinson, M. R., & Packer, N. H. (2020). Lipopolysaccharide and morphine-3-glucuronide-induced immune signalling increases the expression of polysialic acid in PC12 cells. Molecular Neurobiology, 57(2), 964-975. DOI Scopus4 WoS4 Europe PMC2
2020	Iacopetta, K., Collins-Praino, L. E., Buisman-Pijlman, F., Liu, J., Hutchinson, A., & Hutchinson, M. R. (2020). Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review. Nutritional Neuroscience, 23(4), 251-280. DOI Scopus12 WoS10 Europe PMC5
2019	Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2019). Spinal glial adaptations occur in a minimally invasive mouse model of endometriosis: potential implications for lesion etiology and persistent pelvic pain. Reproductive Sciences, 26(3), 1-13. DOI Scopus14 WoS13 Europe PMC7
2019	Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., . . . Wang, X. (2019). Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9577-9587. DOI Scopus15 WoS11 Europe PMC4
2019	Liu, G., Bursill, C., Cartland, S. P., Anwer, A. G., Parker, L. M., Zhang, K., . . . Goldys, E. M. (2019). A nanoparticle-based affinity sensor that identifies and selects highly cytokine-secreting cells. iScience, 20, 137-147. DOI Scopus13 WoS13 Europe PMC6
2019	Musolino, S., Schartner, E., Hutchinson, M., & Salem, A. (2019). Minocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain. European Journal of Pharmacology, 858, 172495-1-172495-10. DOI Scopus2 WoS1
2019	Hutchinson, M. R., & Terry, R. (2019). Review: What innovations in pain measurement and control might be possible if we could quantify the neuroimmune synapse?. Animal, 13(12), 3000-3008. DOI Scopus3 WoS2 Europe PMC1
2019	Chin, P. Y., Dorian, C., Sharkey, D. J., Hutchinson, M. R., Rice, K. C., Moldenhauer, L. M., & Robertson, S. A. (2019). Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology, 160(11), 2646-2662. DOI Scopus10 WoS10 Europe PMC9
2019	Peng, Y., Zhang, X., Zhang, T., Grace, P. M., Li, H., Wang, Y., . . . Wang, X. (2019). Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity, 82, 432-444. DOI Scopus34 WoS34 Europe PMC17
2019	Wang, X., Northcutt, A. L., Cochran, T. A., Zhang, X., Fabisiak, T. J., Haas, M. E., . . . Watkins, L. R. (2019). Methamphetamine activates toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. ACS Chemical Neuroscience, 10(8), 3622-3634. DOI Scopus53 WoS49 Europe PMC33
2019	Zhang, K., Arman, A., Anwer, A., Hutchinson, M., & Goldys, E. (2019). An optical fiber based immunosensor for localized detection of IL-1β in rat spinal cord. Sensors and Actuators, B: Chemical, 282, 122-129. DOI Scopus14 WoS11
2019	Musolino, S. T., Schartner, E. P., Hutchinson, M. R., & Salem, A. (2019). Improved method for optical fiber temperature probe implantation in brains of free-moving rats. Journal of Neuroscience Methods, 313, 24-28. DOI Scopus10 WoS8 Europe PMC1
2019	Parker, L. M., Sayyadi, N., Staikopoulos, V., Shrestha, A., Hutchinson, M. R., & Packer, N. H. (2019). Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization. Journal of Neuroinflammation, 16(1), 65-1-65-13. DOI Scopus6 WoS6 Europe PMC3
2019	Heng, S., Zhang, X., Pei, J., Adwal, A., Reineck, P., Gibson, B. C., . . . Abell, A. D. (2019). Spiropyran-based nanocarrier: a new Zn²⁺-responsive delivery system with real-time intracellular sensing capabilities. Chemistry - A European Journal, 25(3), 854-862. DOI Scopus12 WoS12 Europe PMC1
2019	Colón, M. R., Hutchinson, M. R., Long, A. M., Voelker, G., & Morrison, M. L. (2019). Postbreeding Habitat Use by Golden-Cheeked Warblers (Setophaga chrysoparia). Western North American Naturalist, 79(3), 337-346. DOI Scopus2 WoS2
2018	Hutchinson, M. R., Stoddart, P. R., & Mahadevan-Jansen, A. (2018). Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017. Neurophotonics, 5(4), 1-5. DOI Scopus5 WoS4
2018	Iacopetta, K., Collins-Praino, L., Buisman-Pijlman, F., & Hutchinson, M. (2018). Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?. Brain, Behavior, and Immunity, 73, 125-132. DOI Scopus1 WoS1 Europe PMC2
2018	Li, J., Ebendorff-Heidepriem, H., Gibson, B., Greentree, A. D., Hutchinson, M., Jia, P., . . . Goldys, E. M. (2018). Perspective: biomedical sensing and imaging with optical fibers - innovation through convergence of science disciplines. APL Photonics, 3(10), 1-20. DOI Scopus30 WoS27
2018	Cao, C., Jin, R., Wei, H., Yang, W., Goldys, E. M., Hutchinson, M. R., . . . Liu, G. (2018). Graphene oxide based recyclable in vivo device for amperometric monitoring of interferon-γ in inflammatory mice. ACS Applied Materials and Interfaces, 10(39), 33078-33087. DOI Scopus22 WoS21 Europe PMC9
2018	Hutchinson, M. R. (2018). GLIA AND PAIN. SCIENTIST, 32(1), 34-41.
2018	Zhang, K., Baratta, M., Liu, G., Frank, M., Leslie, N., Watkins, L., . . . Goldys, E. (2018). A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity, 71, 18-22. DOI Scopus27 WoS24 Europe PMC8
2018	Hutchinson, M. R. (2018). ‘Convergence’ created psychoneuroimmunology, and is needed again to secure the future of the field. Brain, Behavior, and Immunity, 71, 1-2. DOI Scopus3 WoS2 Europe PMC2
2018	Bajic, J., Johnston, I., Howarth, G., & Hutchinson, M. (2018). From the bottom-up: chemotherapy and gut-brain axis dysregulation. Frontiers in Behavioral Neuroscience, 12, 104-1-104-16. DOI Scopus61 WoS53 Europe PMC45
2018	Hutchinson, M. (2018). The importance of knowing you are sick: nanoscale biophotonics for the 'other' brain. Microelectronic Engineering, 187-188, 101-104. DOI Scopus4 WoS4
2018	Marcu, L., Boppart, S., Hutchinson, M., Popp, J., & Wilson, B. (2018). Biophotonics: The big picture. Journal of Biomedical Optics, 23(2), 1-7. DOI Scopus19 WoS19 Europe PMC7
2018	Hutchinson, M. R. (2018). Glial ties to persistent pain : Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain. Scientist, 32(1), 34-41.
2018	Liu, J., Mustafa, S., Barratt, D., & Hutchinson, M. (2018). Corticosterone preexposure increases NF-κB translocation and sensitizes IL-1β responses in BV2 microglia-like cells. Frontiers in Immunology, 9(JAN), 1-12. DOI Scopus17 WoS15 Europe PMC11
2018	Robertson, S., Wahid, H., Chin, P., Hutchinson, M., Moldenhauer, L., & Keelan, J. (2018). Toll-like receptor-4: A new target for preterm labour pharmacotherapies?. Current Pharmaceutical Design, 24(9), 960-973. DOI Scopus17 WoS17 Europe PMC12
2018	Zhang, X., Cui, F., Chen, H., Zhang, T., Yang, K., Wang, Y., . . . Wang, X. (2018). Dissecting the innate immune recognition of opioid inactive isomer (+)-naltrexone derived toll-like receptor 4 (TLR4) antagonists. Journal of Chemical Information and Modeling, 58(4), 816-825. DOI Scopus32 WoS29 Europe PMC20
2018	Beckett, E., Staikopoulos, V., & Hutchinson, M. (2018). Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice. Scientific Reports, 8(1), 5923-1-5923-13. DOI Scopus10 WoS10 Europe PMC6
2018	Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity, 67, 181-193. DOI Scopus9 WoS8 Europe PMC7
2018	Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology, 128, 460-473. DOI Scopus12 WoS9 Europe PMC9
2017	Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). Sensitive cytokine assay based on optical fiber allowing localized and spatially resolved detection of interleukin-6. ACS Sensors, 2(2), 218-226. DOI Scopus38 WoS34 Europe PMC9
2017	Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2017). Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis. Biology of Reproduction, 97(6), 810-821. DOI Scopus17 WoS14 Europe PMC9
2017	Zohora, N., Kandjani, A., Orth, A., Brown, H., Hutchinson, M., & Gibson, B. (2017). Fluorescence brightness and photostability of individual copper (I) oxide nanocubes. Scientific Reports, 7(1), 16905-1-16905-8. DOI Scopus6 WoS3 Europe PMC2
2017	Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopy. Applied Spectroscopy Reviews, 52(5), 439-455. DOI Scopus15 WoS14
2017	Johnston, I., Tan, M., Cao, J., Matsos, A., Forrest, D., Si, E., . . . Hutchinson, M. (2017). Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats. Behavioural Brain Research, 334, 109-118. DOI Scopus18 WoS19 Europe PMC10
2017	Liu, G., Zhang, K., Ma, K., Care, A., Hutchinson, M., & Goldys, E. (2017). Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring. Nanoscale, 9(15), 4934-4943. DOI Scopus35 WoS30 Europe PMC6
2017	Lewis, S., Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2017). Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity, 64, 59-64. DOI Scopus2 WoS2 Europe PMC1
2016	Jacobsen, J., Parker, L., Everest-Dass, A., Schartner, E., Tsiminis, G., Staikopoulos, V., . . . Mustafa, S. (2016). Novel imaging tools for investigating the role of immune signalling in the brain. Brain, Behavior, and Immunity, 58, 40-47. DOI Scopus12 WoS11 Europe PMC3
2016	Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Coller, J., White, I., . . . Bowen, J. (2016). Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics, 15(6), 1376-1386. DOI Scopus96 WoS82 Europe PMC60
2016	Lee, S., Hutchinson, M., & Saint, D. (2016). The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology and Physiology, 43(9), 864-871. DOI Scopus24 WoS25 Europe PMC18
2016	Chalmers, K., Madden, V., Hutchinson, M., & Moseley, G. (2016). Local and systemic inflammation in localized, provoked vestibulodynia. Obstetrics and Gynecology, 128(2), 337-347. DOI Scopus17 WoS12 Europe PMC8
2016	Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). Portable optical fiber probe for in vivo brain temperature measurements. Biomedical Optics Express, 7(8), 3069-3078. DOI Scopus52 WoS45 Europe PMC8
2016	Ellis, A., Grace, P., Wieseler, J., Favret, J., Springer, K., Skarda, B., . . . Watkins, L. (2016). Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity, 58, 348-356. DOI Scopus54 WoS49 Europe PMC36
2016	Dodds, K., Beckett, E., Evans, S., Grace, P., Watkins, L., & Hutchinson, M. (2016). Glial contributions to visceral pain : implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry, 6(9), e888-1-e888-13. DOI Scopus41 WoS41 Europe PMC30
2016	Somogyi, A., Sia, A., Tan, E., Coller, J., Hutchinson, M., & Barratt, D. (2016). Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain, 157(11), 2458-2466. DOI Scopus21 WoS18 Europe PMC9
2016	Chin, P., Dorian, C., Hutchinson, M., Olson, D., Rice, K., Moldenhauer, L., & Robertson, S. (2016). Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports, 6(1), 36112-1-36112-13. DOI Scopus53 WoS51 Europe PMC39
2016	Grace, P., Gaudet, A., Staikopoulos, V., Maier, S., Hutchinson, M., Salvemini, D., & Watkins, L. (2016). Nitroxidative signaling mechanisms in pathological pain. Trends in Neurosciences, 39(12), 862-879. DOI Scopus82 WoS78 Europe PMC52
2016	Gibson, R., Coller, J., Wardill, H., Hutchinson, M., Smid, S., & Bowen, J. (2016). Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer, 24(5), 2251-2258. DOI Scopus20 WoS20 Europe PMC10
2016	Wang, X., Zhang, Y., Peng, Y., Hutchinson, M., Rice, K., Yin, H., & Watkins, L. (2016). Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. British Journal of Pharmacology, 173(5), 856-869. DOI Scopus113 WoS102 Europe PMC69
2016	Jacobsen, J., Hutchinson, M., & Mustafa, S. (2016). Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology, 26, 131-137. DOI Scopus24 WoS25 Europe PMC15
2016	Liu, G., Qi, M., Hutchinson, M., Yang, G., & Goldys, E. (2016). Recent advances in cytokine detection by immunosensing. Biosensors and Bioelectronics, 79, 810-821. DOI Scopus105 WoS96 Europe PMC37
2015	Ingman, W., Glynn, D., & Hutchinson, M. (2015). Mouse models of mastitis - how physiological are they?. International Breastfeeding Journal, 10(1), 12-1-12-5. DOI Scopus14 WoS14 Europe PMC13
2015	Lee, S., Hutchinson, M., Staikopoulos, V., & Saint, D. (2015). Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. International Journal of Cardiology, 190, 353-359. DOI Scopus9 WoS8 Europe PMC5
2015	Wahid, H., Dorian, C., Chin, P., Hutchinson, M., Rice, K., Olson, D., . . . Robertson, S. (2015). Toll-like receptor 4 Is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology, 156(10), 3828-3841. DOI Scopus51 WoS48 Europe PMC32
2015	Bachtell, R., Hutchinson, M., Wang, X., Rice, K., Maier, S., & Watkins, L. (2015). Targeting the toll of drug abuse: the translational potential of toll-like receptor 4. CNS and Neurological Disorders - Drug Targets, 14(6), 692-699. DOI Scopus62 WoS57 Europe PMC45
2015	Johnson, J. L., Kwok, Y. H., Sumracki, N. M., Swift, J. E., Hutchinson, M. R., Johnson, K., . . . Rolan, P. E. (2015). Glial attenuation with ibudilast in the treatment of medication overuse headache: a double-blind, randomized, placebo-controlled pilot trial of efficacy and safety. Headache, 55(9), 1192-1208. DOI Scopus13 WoS13 Europe PMC8
2015	Corrigan, F., Wu, Y., Tuke, J., Coller, J., Rice, K., Diener, K., . . . Hutchinson, M. (2015). Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity, 45, 245-252. DOI Scopus19 WoS17 Europe PMC18
2015	Northcutt, A., Hutchinson, M., Wang, X., Baratta, M., Hiranita, T., Cochran, T., . . . Watkins, L. (2015). DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry, 20(12), 1525-1537. DOI Scopus155 WoS146 Europe PMC98
2015	Li, Y., Jackson, K., Slon, B., Hardy, J., Franco, M., William, L., . . . Somogyi, A. (2015). CYP2B66 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects. British Journal of Clinical Pharmacology*, 80(2), 276-284. DOI Scopus44 WoS37 Europe PMC26
2015	Lewis, S., Hutchinson, M., Frick, M., Zhang, Y., Maier, S., Sammakia, T., . . . Watkins, L. (2015). Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity, 44, 128-136. DOI Scopus13 WoS12 Europe PMC7
2014	Liu, J., Buisman-Pijlman, F., & Hutchinson, M. (2014). Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder. Frontiers in Neuroscience, 8(SEP), 309-1-309-15. DOI Scopus84 WoS67 Europe PMC53
2014	Jacobsen, J., Watkins, L., & Hutchinson, M. (2014). Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology, 118, 129-163. DOI Scopus48 WoS41 Europe PMC36
2014	Hutchinson, M. R. (2014). Want more pain? Just add a dash of endotoxin to enhance your clinical pain model. Brain, Behavior, and Immunity, 41(1), 44-45. DOI Scopus8 WoS7 Europe PMC5
2014	Watkins, L. R., & Hutchinson, M. R. (2014). A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: Comment on Smith and Dragunow. Trends in Neurosciences, 37(4), 189-190. DOI Scopus10 WoS9 Europe PMC5
2014	Johnson, J., Rolan, P., Johnson, M., Bobrovskaya, L., Williams, D., Johnson, K., . . . Hutchinson, M. (2014). Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry, 4(11), e482-1-e482-9. DOI Scopus28 WoS28 Europe PMC22
2014	Grace, P., Ramos, K., Rodgers, K., Wang, X., Hutchinson, M., Lewis, M., . . . Watkins, L. (2014). Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience, 280, 299-317. DOI Scopus55 WoS51 Europe PMC39
2014	Nicotra, L., Tuke, S., Grace, P., Rolan, P., & Hutchinson, M. (2014). Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?. Frontiers in Behavioral Neuroscience, 8(February), 1-16. DOI Scopus35 WoS32 Europe PMC22
2014	Sumracki, N., Buisman-Pijlman, F., Hutchinson, M., Gentgall, M., & Rolan, P. (2014). Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine, 15(4), 647-660. DOI Scopus14 WoS14 Europe PMC7
2014	Narayan, D., Casson, R., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Wood, J. (2014). Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. Clinical and Experimental Ophthalmology, 42(6), 539-554. DOI Scopus5 WoS2 Europe PMC1
2014	Glynn, D., Hutchinson, M., & Ingman, W. (2014). Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction, 90(5), 1-11. DOI Scopus24 WoS24 Europe PMC18
2014	Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2014). Pathological pain and the neuroimmune interface. Nature Reviews Immunology, 14(4), 217-231. DOI Scopus621 WoS590 Europe PMC421
2014	Watkins, L. R., Wang, X., Mustafa, S., & Hutchinson, M. R. (2014). In vivo veritas: (+)-Naltrexone's actions define translational importance. A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences, 35(9), 432-433. DOI Scopus15 WoS14 Europe PMC11
2014	Ingman, W., Glynn, D., & Hutchinson, M. (2014). Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia, 19(2), 161-167. DOI Scopus50 WoS47 Europe PMC31
2014	Zwicker, J., Zhang, Y., Ren, J., Hutchinson, M., Rice, K., Watkins, L., . . . Funk, G. (2014). Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology, 117(8), 857-868. DOI Scopus12 WoS11 Europe PMC8
2014	Mulholland, C., Somogyi, A., Barratt, D., Coller, J., Hutchinson, M., Jacobson, G., . . . Sleigh, J. (2014). Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia. Journal of Molecular Neuroscience, 52(4), 497-506. DOI Scopus13 WoS11 Europe PMC8
2014	Hutchinson, M., & Watkins, L. (2014). Why is neuroimmunopharmacology crucial for the future of addiction research?. Neuropharmacology, 76(Part B), 218-227. DOI Scopus75 WoS75 Europe PMC58
2014	Stewart, L. R., Morrison, M. L., Hutchinson, M. R., Appel, D. N., & Wilkins, R. N. (2014). Effects of a forest pathogen on habitat selection and quality for the endangered golden-cheeked warbler. Wildlife Society Bulletin, 38(2), 279-287. DOI Scopus12 WoS12
2013	Thomas, J., & Hutchinson, M. R. (2013). Erratum: Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (Expert Review of Neurotherapeutics (2012) 12:11 (1311-1324)). Expert Review of Neurotherapeutics, 13(3), 339-340. DOI
2013	Thomas, J., & Hutchinson, M. R. (2013). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (vol 12, pg 1311, 2012). EXPERT REVIEW OF NEUROTHERAPEUTICS, 13(3), 339-340.
2013	Kwok, Y., Tuke, S., Nicotra, L., Grace, P., Rolan, P., & Hutchinson, M. (2013). TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. PLoS One, 8(10), 1-16. DOI Scopus19 WoS16 Europe PMC14
2013	Della Vedova, C., Cathcart, S., Dohnalek, A., Lee, V., Hutchinson, M., Immink, M., & Hayball, J. (2013). Peripheral interleukin-1β levels are elevated in chronic tension-type headache patients. Pain Research & Management : The Journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur, 18(6), 301-306. DOI Scopus29 WoS22 Europe PMC16
2013	Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Stanley, N., . . . Somogyi, A. (2013). The CYP2B66 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition*, 41(6), 1264-1272. DOI Scopus37 WoS34 Europe PMC21
2013	Hutchinson, M., Bujis, M., Tuke, S., Kwok, Y., Gentgall, M., Williams, D., & Rolan, P. (2013). Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behavior and Immunity, 30, 3-11. DOI Scopus51 WoS47 Europe PMC28
2013	Theberge, F., Li, X., Kambhampati, S., Pickens, C., St Laurent, R., Bossert, J., . . . Shaham, Y. (2013). Effect of chronic delivery of the toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry, 73(8), 729-737. DOI Scopus95 WoS89 Europe PMC78
2013	Lewis, S., Hutchinson, M., Zhang, Y., Hund, D., Maier, S., Rice, K., & Watkins, L. (2013). Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behavior and Immunity, 30, 24-32. DOI Scopus46 WoS43 Europe PMC36
2013	Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia, 33(1), 52-64. DOI Scopus37 WoS35 Europe PMC23
2012	Jalleh, R., Koh, K., Choi, B., Liu, E., Maddison, J., & Hutchinson, M. (2012). Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Medical Hypotheses, 79(6), 735-739. DOI Scopus21 WoS17 Europe PMC13
2012	Kwok, Y., Hutchinson, M., Gentgall, M., & Rolan, P. (2012). Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. PLoS One, 7(8), 1-8. DOI Scopus42 WoS41 Europe PMC31
2012	Hutchinson, M., Northcutt, A., Hiranita, T., Wang, X., Lewis, S., Thomas, J., . . . Watkins, L. (2012). Opioid activation of toll-like receptor 4 contributes to drug reinforcement. Journal of Neuroscience, 32(33), 11187-11200. DOI Scopus226 WoS198 Europe PMC162
2012	Grace, P., Hurley, D., Barratt, D., Tsykin, A., Watkins, L., Rolan, P., & Hutchinson, M. (2012). Harnessing pain heterogeneity and RNA transcriptome to idenitfy blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic construction injury model. Journal of Neurochemistry, 122(5), 976-994. DOI Scopus22 WoS22 Europe PMC14
2012	Watkins, L., Hutchinson, M., & Johnson, K. (2012). Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology, 234(2), 351-353. DOI Scopus18 WoS17 Europe PMC17
2012	Corrigan, F., & Hutchinson, M. (2012). Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling?. Expert Review of Clinical Immunology, 8(3), 201-203. DOI Scopus6 WoS4 Europe PMC3
2012	Sumracki, N., Hutchinson, M., Gentgall, M., Briggs, N., Williams, D., & Rolan, P. (2012). The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One, 7(6), 1-8. DOI Scopus20 WoS18 Europe PMC13
2012	Lewis, S., Loram, L., Hutchinson, M., Li, C., Zhang, Y., Maier, S., . . . Watkins, L. (2012). (+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain, 13(5), 498-506. DOI Scopus82 WoS76 Europe PMC64
2012	Wang, X., Loram, L., Ramos, K., de Jesus, A., Thomas, J., Cheng, K., . . . Yin, H. (2012). Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6325-6330. DOI Scopus339 WoS331 Europe PMC248
2012	Coller, J., & Hutchinson, M. (2012). Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & Therapeutics, 134(2), 219-245. DOI Scopus141 WoS128 Europe PMC105
2012	Nicotra, L., Loram, L., Watkins, L., & Hutchinson, M. (2012). Toll-like receptors in chronic pain. Experimental Neurology, 234(2), 316-329. DOI Scopus194 WoS177 Europe PMC129
2012	Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Coller, J., Rice, K., . . . Hutchinson, M. (2012). Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology, 165(5), 1319-1329. DOI Scopus67 WoS57 Europe PMC51
2012	Thomas, J., & Hutchinson, M. (2012). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids. Expert Review of Neurotherapeutics, 12(11), 1311-1324. DOI Scopus10 WoS10 Europe PMC5
2011	Schwarz, J., Hutchinson, M., & Bilbo, S. (2011). Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. The Journal of Neuroscience, 31(49), 17835-17847. DOI Scopus145 WoS139 Europe PMC112
2011	Anderson, P., Hutchinson, M., Irvine, R., & Salem, A. (2011). Attenuating glial activation with minocycline reduces the hyperthermic response to 3, 4-methylenedioxymethamphetamine (MDMA) in the rat. The Open Addiction Journal, 4(Sp Iss), 4-5. DOI
2011	Salem, A., Gordon, J., Hutchinson, M., & Irvine, R. (2011). 3,4-Methylenedioxymethamphetamine (MDMA) induced hyperthermia - the role of pro-inflammatory cytokines. The Open Addiction Journal, 4(Sp Iss), 48-49. DOI
2011	Grace, P., Rolan, P., & Hutchinson, M. (2011). Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behavior and Immunity, 25(7), 1322-1332. DOI Scopus90 WoS84 Europe PMC68
2011	Liu, L., Ghosh, N., Slivka, P., Fiorini, Z., Hutchinson, M., Watkins, L., & Yin, H. (2011). An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. ChemBioChem, 12(12), 1827-1831. DOI Scopus14 WoS13 Europe PMC10
2011	Liu, L., Coller, J., Watkins, L., Somogyi, A., & Hutchinson, M. (2011). Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains. Brain Behavior and Immunity, 25(6), 1223-1232. DOI Scopus51 WoS47 Europe PMC39
2011	Hutchinson, M., Shavit, Y., Grace, P., Rice, K., Maier, S., & Watkins, L. (2011). Exploring the neuroimmunopharmacology of opioids: An integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews, 63(3), 772-810. DOI Scopus310 WoS289 Europe PMC215
2011	Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Robertson, S., Coller, J., . . . Hutchinson, M. (2011). Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behavior and Immunity, 25(Suppl 1), 155-164. DOI Scopus66 WoS52 Europe PMC43
2011	Grace, P., Hutchinson, M., Bishop, A., Somogyi, A., Mayrhofer, G., & Rolan, P. (2011). Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain Behavior and Immunity, 25(3), 503-513. DOI Scopus23 WoS21 Europe PMC18
2010	Grace, P., Hutchinson, M., Manavis, J., Somogyi, A., & Rolan, P. (2010). A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods, 193(1), 47-53. DOI Scopus39 WoS38 Europe PMC31
2010	Joce, C., Stahl, J., Shridhar, M., Hutchinson, M., Watkins, L., Fedichev, P., & Yin, H. (2010). Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters, 20(18), 5411-5413. DOI Scopus34 WoS32 Europe PMC24
2010	Stanley, N., Hutchinson, M., Kvist, T., Nielsen, B., Mathiesen, J., Brauner-Osborne, H., . . . Taylor, D. (2010). A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry, 18(16), 6089-6098. DOI Scopus5 WoS4
2010	Buchanan, M., Hutchinson, M., Watkins, L., & Yin, H. (2010). Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry, 114(1), 13-27. DOI Scopus274 WoS264 Europe PMC194
2010	Hutchinson, M., Zhang, Y., Shridhar, M., Evans, J., Buchanan, M., Zhao, T., . . . Watkins, L. (2010). Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behavior and Immunity, 24(1), 83-95. DOI Scopus395 WoS369 Europe PMC289
2010	Lewis, S., Hutchinson, M., Rezvani, N., Loram, L., Zhang, Y., Maier, S., . . . Watkins, L. (2010). Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience, 165(2), 569-583. DOI Scopus138 WoS129 Europe PMC94
2010	Hutchinson, M., Loram, L., Zhang, Y., Shridhar, M., Rezvani, N., Berkelhammer, D., . . . Watkins, L. (2010). Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience, 168(2), 551-563. DOI Scopus77 WoS68 Europe PMC47
2010	Hutchinson, M., Lewis, S., Coats, B., Rezvani, N., Zhang, Y., Wieseler, J., . . . Watkins, L. (2010). Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience, 167(3), 880-893. DOI Scopus106 WoS95 Europe PMC85
2009	Slivka, P., Shridhar, M., Lee, G., Sammond, D., Hutchinson, M., Martinko, A., . . . Yin, H. (2009). A Peptide Antagonist of the TLR4-MD2 Interaction. ChemBioChem, 10(4), 645-649. DOI Scopus40 WoS40 Europe PMC26
2009	Rolan, P., Hutchinson, M., & Johnson, K. (2009). Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy, 10(17), 2897-2904. DOI Scopus109 WoS107 Europe PMC73
2009	Hutchinson, M., Ramos, K., Loram, L., Wieseler-Frank, J., Sholar, P., Kearney, J., . . . Watkins, L. (2009). Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience, 164(4), 1821-1832. DOI Scopus64 WoS60 Europe PMC43
2009	Loram, L., Harrison, J., Sloane, E., Hutchinson, M., Sholar, P., Taylor, F., . . . Watkins, L. (2009). Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: A novel therapy for neuropathic pain. Journal of Neuroscience, 29(44), 14015-14025. DOI Scopus89 WoS79 Europe PMC57
2009	Liu, L., Hutchinson, M., White, J., Somogyi, A., & Coller, J. (2009). Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics (Print Edition), 19(11), 869-876. DOI Scopus40 WoS36 Europe PMC29
2009	Watkins, L., Hutchinson, M., Rice, K., & Maier, S. (2009). The "Toll" of Opiod-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia. Trends in Pharmacological Sciences, 30(11), 581-591. DOI Scopus309 WoS286 Europe PMC222
2009	Rodgers, K., Hutchinson, M., Northcutt, A., Maier, S., Watkins, L., & Barth, D. (2009). The cortical innate immune response increases local neuronal excitability leading to seizures. Brain, 132(9), 2478-2486. DOI Scopus122 WoS119 Europe PMC92
2009	Bland, S., Hutchinson, M., Maier, S., Watkins, L., & Johnson, K. (2009). The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behavior and Immunity, 23(4), 492-497. DOI Scopus76 WoS66 Europe PMC58
2009	Hutchinson, M., Lewis, S., Coats, B., Skyba, D., Crysdale, N., Berkelhammer, D., . . . Johnson, K. (2009). Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behavior and Immunity, 23(2), 240-250. DOI Scopus201 WoS193 Europe PMC148
2008	Hutchinson, M., Coats, B., Lewis, S., Zhang, Y., Sprunger, D., Rezvani, N., . . . Watkins, L. (2008). Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behavior and Immunity, 22(8), 1178-1189. DOI Scopus252 WoS227 Europe PMC176
2008	Hutchinson, M., Northcutt, A., Chao, L., Kearney, J., Zhang, Y., Berkelhammer, D., . . . Maier, S. (2008). Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behavior and Immunity, 22(8), 1248-1256. DOI Scopus153 WoS139 Europe PMC100
2008	Hutchinson, M., Zhang, Y., Brown, K., Coats, B., Shridhar, M., Sholar, P., . . . Watkins, L. (2008). Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience, 28(1), 20-29. DOI Scopus318 WoS306 Europe PMC246
2007	Watkins, L., Hutchinson, M., Milligan, E., & Maier, S. (2007). 'Listening' and 'talking' to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews, 56(1), 148-169. DOI Scopus157 WoS135 Europe PMC110
2007	Der-Avakian, A., Bland, S., Rozeske, R., Tamblyn, J., Hutchinson, M., Watkins, L., & Maier, S. (2007). The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology, 191(4), 909-917. DOI Scopus36 WoS33 Europe PMC26
2007	Watkins, L., Hutchinson, M., Ledeboer, A., Wieseler-Frank, J., Milligan, E., & Maier, S. (2007). Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids. Brain Behavior and Immunity, 21(2), 131-146. DOI Scopus294 WoS260 Europe PMC198
2007	Hutchinson, M., Johnson, K., Rice, K., Maier, S., & Watkins, L. (2007). Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. The Scientific World Journal, 7(Suppl 2), 98-111. DOI Scopus291 WoS14 Europe PMC171
2007	Ledeboer, A., Hutchinson, M., Watkins, L., & Johnson, K. (2007). Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion on Investigational Drugs, 16(7), 935-950. DOI Scopus124 WoS115 Europe PMC78
2005	Hutchinson, M., & Somogyi, A. (2005). Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. International Immunopharmacology, 5(12), 1713-1722. DOI Scopus6 WoS4 Europe PMC4
2005	Watkins, L., Hutchinson, M., Johnston, I., & Maier, S. (2005). Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences, 28(12), 661-669. DOI Scopus286 WoS259 Europe PMC189
2004	Hutchinson, M., & Somogyi, A. (2004). (S)-(+)methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone. International Immunopharmacology, 4(12), 1525-1530. DOI Scopus13 WoS12 Europe PMC10
2004	Hutchinson, M., La Vincente, S., & Somogyi, A. (2004). In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. Pain, 110(3), 751-755. DOI Scopus13 WoS11 Europe PMC10
2004	Hutchinson, M., & Somogyi, A. (2004). Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. European Journal of Pharmacology, 494(2-3), 251-262. DOI Scopus9 WoS7 Europe PMC7
2004	Hutchinson, M., Menelaou, A., Foster, D., Coller, J., & Somogyi, A. (2004). CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology, 57(3), 287-297. DOI Scopus128 WoS96 Europe PMC63
2003	Menelaou, A., Hutchinson, M., Quinn, I., Christensen, A., & Somogyi, A. (2003). Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 785(1), 81-88. DOI Scopus23 WoS19 Europe PMC12
2002	Hutchinson, M., & Somogyi, A. (2002). Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. European Journal of Pharmacology, 453(1), 27-32. DOI Scopus18 WoS18 Europe PMC13
-	Zabolocki, M., McCormack, K., van den Hurk, M., Milky, B., Shoubridge, A., Adams, R., . . . Bardy, C. (n.d.). BrainPhys neuronal medium optimized for imaging and optogenetics in vitro. DOI
-	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Tables 1-5. DOI

Book Chapters

Year	Citation
2022	Mustafa, S., Evans, S., Barry, B., Barratt, D., Wang, Y., Lin, C., . . . Hutchinson, M. R. (2022). Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems.. In V. Kumar (Ed.), Toll-like Receptors in Health and Disease. Handbook of Experimental Pharmacology (Vol. 276, pp. 239-273). Springer Berlin Heidelberg. DOI Europe PMC1
2018	Holmes, J., Corrigan, F., & Hutchinson, M. R. (2018). Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression. In B. T. Baune (Ed.), Inflammation and Immunity in Depression Basic Science and Clinical Applications (pp. 223-240). United Kingdom: Academic Press. DOI
2015	Thomas, J., Sanam, M., Johnson, J., & Nicotra, L. (2015). The relationship between opioids and immune signalling in the spinal cord. In Pain Control (Vol. 227, pp. 207-238). Springer Berlin Heidelberg. DOI Scopus16 Europe PMC8
2014	Wang, X., Cochran, T. A., Hutchinson, M. R., Yin, H., & Watkins, L. R. (2014). Drug addiction. In M. E. Tremblay, & A. Sierra (Eds.), Microglia in health and disease (pp. 299-317). Online: Springer New York. DOI Scopus5
2013	Sumracki, N., Nicotra, L., Kwok, Y., Liu, L., Steeg, K., Watkins, L., & Hutchinson, M. (2013). The future: new concepts and potential therapies. In C. Toth, & D. Moulin (Eds.), Neuropathic pain: causes, management and understanding (1 ed., pp. 341-356). United Kingdom: Cambridge University Press. DOI
2013	Wu, Y., & Hutchinson, M. (2013). Therapeutic strategies to treat alcohol-related disorders targeting central immune signaling. In C. Cui, L. Grandison, & A. Noronha (Eds.), Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (1 ed., pp. 535-559). United States: Springer. DOI
2013	The Wiley‐Blackwell Handbook of Psychoneuroimmunology (2013). Wiley. DOI
2013	The Wiley‐Blackwell Handbook of Psychoneuroimmunology (2013). Wiley. DOI
2013	Grace, P. M., Watkins, L. R., & Hutchinson, M. R. (2013). Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions. In The Wiley-Blackwell Handbook of Psychoneuroimmunology (pp. 176-197). Wiley. DOI
2012	Grace, P., Watkins, L., & Hutchinson, M. (2012). The Role of the Immune System in Chronic Pain Comorbidities. In M. Giamberardino, & T. Jensen (Eds.), Pain Comorbidities: Understanding and Treating the Complex Patient (1 ed., pp. 137-155). Seattle, WA: USA: IASP Press (International Association for the Study of Pain).
2009	Gordon, A., Hutchinson, M., La Vincente, S., Mitchell, T., Morrish, G., Newcombe, D., . . . White, J. (2009). Pharmacology of opioid agonists and antagonists. In R. Mattick, R. Ali, & N. Lintzeris (Eds.), Pharmacotherapies for the Treatment of Opioid Dependence: Efficacy, Cost-Effectiveness and Implementation Guidelines (pp. 15-53). New York, USA: Informa.
2007	Watkins, L. R., Wieseler-Frank, J., Hutchinson, M. R., Ledeboer, A., Spataro, L., Milligan, E. D., . . . Maier, S. F. (2007). Neuroimmune interactions and pain: The role of immune and glial cells. In Psychoneuroimmunology, Two-Volume Set (Vol. 1, pp. 393-414). Elsevier. DOI Scopus6
2006	Watkins, L. R., Wieseler-Frank, J., Hutchinson, M. R., Ledeboer, A., Spataro, L., Milligan, E. D., . . . Maier, S. F. (2006). Neuroimmune Interactions and Pain: The Role of Immune and Glial Cells. In Psychoneuroimmunology (pp. 393-414). DOI Scopus2

Conference Papers

Year	Citation
2019	Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2019). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015 (pp. 1). online: OSA Publishing.
2019	Schartner, E., Tsiminis, G., Henderson, M., Hutchinson, M., & Monro, T. (2019). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015. online: OSA Publishing.
2019	Kostecki, R., Zhang, B., El Habti, A., Arman, A., Hutchinson, M., Tricker, P., . . . Ebendorff-Heidepriem, H. (2019). Reversible protein carbonylation in-vivo biosensor. In osapublishing.org Vol. Part F166-Sensors 2019 (pp. 1-2). online: OSA. DOI
2019	Peng, L., Khalid, A., Warren-Smith, S. C., Arman, A., Schartner, E. P., Sylvia, G. M., . . . Li, J. (2019). Chemical sensing based on silk coated exposed-core fibers. In E. M. Goldys, & B. C. Gibson (Eds.), Biophotonics Australasia 2019 Vol. 11202 (pp. 112020G-1-112020G-2). Bellingham, Washington: SPIE. DOI
2019	Kostecki, R., Zhang, B., El Habti, A., Arman, A., Hutchinson, M. R., Tricker, P. J., . . . Ebendorff-Heidepriem, H. (2019). Optical fiber based in-vivo oxidative stress biosensor. In Proceedings of SPIE - The International Society for Optical Engineering Vol. 11202 (pp. 1-3). online: SPIE. DOI WoS1
2017	Hutchinson, M. R. (2017). The importance of knowing you are sick: Biophotonics for the 'Other' brain. In Optics InfoBase Conference Papers Vol. Part F41-CLEO_SI 2017 (pp. 1 page). San Jose, CA: IEEE. DOI WoS1
2017	Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). An optical fibre based ex-vivo device for detection of cytokines. In IET Conference Publications Vol. 2017 (pp. 1-4). online: IET Digital Library. DOI
2017	Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In Proceedings of the 29th IEEE Photonics Conference (pp. 684-685). Waikoloa, HI: IEEE. DOI Scopus1 WoS1
2016	Tsiminis, G., Schartner, E., Bekteshi, M., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow-core optical fibers made by glass billet extrusion as sensors for raman spectroscopy. In Optics InfoBase Conference Papers Vol. Part F3-ACOFT 2016 (pp. 1-2). online: OSA. DOI
2016	Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). A portable optical fiber probe for in vivo brain temperature measurements. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING. DOI Scopus2 WoS1
2016	Staikopoulos, V., Gosnell, M., Anwer, A., Mustafa, S., Hutchinson, M., & Goldys, E. (2016). Hyperspectral imaging of endogenous fluorescent metabolic molecules to identify pain states in central nervous system tissue. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 1-8). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING. DOI Scopus3 WoS3
2016	Peddie, V., Heng, S., Mustafa, S., Thomas, J., Hutchinson, M., & Abell, A. (2016). Shapeshifting photoswitchable azobenzene compounds and their biological applications. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING. DOI
2016	Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2016). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE: SPIE BioPhotonics Australasia Conference Vol. 10013 (pp. 100130M-1-100130M-4). Adelaide, Australia: SPIE. DOI
2016	Tsiminis, G., Schartner, E., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow core optical fibres made by glass billet extrusion as sensors for Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING. DOI
2016	Bajic, J., Whittaker, A., Bobrovskaya, L., Hutchinson, M., & Howarth, G. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. In Australian Society for Medical Research. Adelaide.
2016	Whittaker, A. L., Bajic, J. E., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Chemotherapy Induces Intestinal Inflammation and Central Changes Which Are Modified by Analgesics via Neuro-Immune Mechanisms. In GASTROENTEROLOGY Vol. 150 (pp. S52). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI
2015	Dodds, K., Beckett, E., Staikopoulos, V., Evans, S., & Hutchinson, M. (2015). Novel mouse model of endometriosis permits identification of spinal glia and nociception characteristics involved in pelvic pain. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 267). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015	Staikopoulos, V., Jin, D., Lu, Y., Gibson, B., Reineck, P., Goldys, E., . . . Hutchinson, M. (2015). Ultra-structural imaging in cleared mouse cns using nanoparticles. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 382). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015	Jacobsen, J., Staikopoulos, V., & Hutchinson, M. (2015). Optimisation and utilisation of a novel whole-brain imaging technique (clarity) to analyse addiction-like behaviours. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 351). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015	Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Optics InfoBase Conference Papers.
2015	Schartner, E. P., Musolino, S., Salem, A., Hutchinson, M. R., & Monro, T. M. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015.
2015	Schartner, E. P., Tsiminis, G., Henderson, M. R., Hutchinson, M. R., & Monro, T. M. (2015). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015.
2015	Schartner, E. P., Musolino, S., Salem, A., Hutchinson, M. R., & Monro, T. M. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Optics InfoBase Conference Papers.
2015	Schartner, E. P., Tsiminis, G., Henderson, M. R., Hutchinson, M. R., & Monro, T. M. (2015). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. In Optics InfoBase Conference Papers.
2014	Maeda, H. (2014). THE EPR EFFECT AND BEYOND FOR CANCER SELECTIVE DRUG DELIVERY FOR TREATMENT AND IMAGING USING NANOMEDICINE. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 15). Toronto, CANADA: INFORMA HEALTHCARE.
2014	Narayan, D., Casson, R. J., Ebneter, A., Chidlow, G., Grace, P. M., Hutchinson, M. R., & Wood, J. P. M. (2014). Immune priming and experimental glaucoma: The effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55 (pp. 7 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
2007	Hutchinson, M. R., Coats, B. D., Zhang, Y., Lewis, S. S., Sprunger, D. B., Baker, E. M., . . . Watkins, L. R. (2007). Opioid-induced glial activation via a non-classical opioid receptor: clinical implications & the search for the target. In NEURON GLIA BIOLOGY Vol. 2 (pp. S16). CAMBRIDGE UNIV PRESS. WoS1

Conference Items

Year	Citation
2020	Ho, R. M., Yin, C. P., Robertson, S. A., Hutchinson, M. L., & Keelan, J. A. (2020). Comparative Effects of TLR4 Inhibitors on Inflammatory Activation in Human Decidual Cells.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG.
2016	Bajic, J. E., Whittaker, A. L., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. Poster session presented at the meeting of Multinational Association for Supportive Care in Cancer. Adelaide.
2015	Bajic, J., Howarth, G., Eden, G., Lampton, L., Mashtoub, S., & Hutchinson, M. (2015). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Neurochemistry. Cairns, Australia: Wiley. DOI WoS1
2014	Bajic, J. E., Howarth, G. S., Eden, G. L., Lampton, L. S., Mashtoub, S., & Hutchinson, M. R. (2014). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley. DOI
2014	Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2014). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. Poster session presented at the meeting of Optics InfoBase Conference Papers.
2014	Schartner, E., Tsiminis, G., Henderson, M., Hutchinson, M., & Monro, T. (2014). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. Poster session presented at the meeting of Optics InfoBase Conference Papers.
2014	Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Currow, D., . . . Somogyi, A. (2014). Cyp2B66 Allele Alters Ketamine'S Pharmacokinetics In Chronic Pain Patients And Metabolism In Vitro*. Poster session presented at the meeting of Drug Metabolism Reviews. Toronto, CANADA: Informa Healthcare. DOI Europe PMC1
2014	Robertson, S. A., Chin, P. -Y., Dorian, C., & Hutchinson, M. (2014). Inhibition of the TLR4 Signalling Pathway Protects Mice from LPS-Induced Preterm Delivery. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
2014	Robertson, S. A., Wahid, H. W., Dorian, C., Hutchinson, M., & Olson, D. M. (2014). Toll-Like Receptor 4 (TLR4) Signalling Is Implicated in Normal On-Time Labour in Mice. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
2013	Rolan, P. E., Hutchinson, M. R., Buijs, M., Tuke, J., Kwok, Y. H., Gentgall, M., . . . Nillsen, N. (2013). First demonstration of the neuroimmune link in humans using IV Endotoxin and Intradermal Capsaicin in the face and arm. Poster session presented at the meeting of JOURNAL OF HEADACHE AND PAIN. SPRINGER-VERLAG ITALIA SRL. DOI
2013	Kwiatek, R., Hutchinson, M., Cleland, L., Limaye, V., True, B., Lubhan, C., . . . Coller, J. (2013). GENETIC VARIABILITY IN CYTOKINE AND CYTOKINE RECEPTORS IN FIBROMYALGIA - A PILOT STUDY. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013	Hutchinson, M. R. (2013). THE PROINFLAMMATORY HYPOTHESIS OF ADDICTION: CLINICAL AND PRECLINICAL EVIDENCE.. Poster session presented at the meeting of JOURNAL OF NEUROIMMUNE PHARMACOLOGY. SPRINGER.
2013	Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Codeine, Increasing Pain & Medication Overuse Headache: The First Evidence of Codeine-Induced Hyperalgesia. Poster session presented at the meeting of CEPHALALGIA. Boston, MA: SAGE PUBLICATIONS LTD.
2012	Zwicker, J. D., Zhang, Y., Hutchinson, M. R., Rice, K. C., Watkins, L. R., & Funk, G. D. (2012). Microglia attenuate the opioid-induced depression of preBotzinger Complex (preBotC) inspiratory rhythm in vitro via a TLR4-independent pathway. Poster session presented at the meeting of FASEB JOURNAL. San Diego, CA: FEDERATION AMER SOC EXP BIOL. WoS1
2012	Narayan, D., Wood, J., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Casson, R. (2012). IMMUNE PRIMING AND EXPERIMENTAL GLAUCOMA: THE EFFECT OF PRIOR SYSTEMIC LIPOPOLYSACCHARIDE CHALLENGE ON TISSUE OUTCOMES AFTER OPTIC NERVE INJURY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL.

Internet Publications

Year	Citation
-	Morphett, J., Whittaker, A., Reichelt, A., & Hutchinson, M. (n.d.). Perineuronal net structure as a non-cellular mechanism of affective state, a scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols. DOI

Datasets

Year	Citation
-	Liddicoat, C., Sydnor, H., Cando-Dumancela, C., Dresken, R., Liu, J., Gellie, N., . . . Breed, M. (n.d.). Supporting Data - Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice. DOI

Figures

Year	Citation
-	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Figure 1. DOI

My research program has been funded by the following grant schemes

DSTG, Centre for Advanced Defence Research and Enterprise – OCE
DSTG, Defence Science Technology Group - SynBioGen programs
DSTG, Human Integrated Sensor System Program - Meat and Livestock Australia
ARC Future Fellowship (FT180100565; Sole CI)
ARC discovery grant that includes an ARF (DP110100297; Sole CI)
NHMRC CJ Martin Postdoctoral Fellowship (Sole CI)
NHMRC project grant (APP1026178; CIB).
ARC Centre of Excellence for Nanoscale BioPhotonics ($38M, CE140100003)
NIH R01 grants as a PI (R01 DA034185; R01 DA025978; R01 DA23132; R01 DE017782)
USA Department of Defence CDMRP grant ($614K)
National Breast Cancer Foundation of Australia ($112K)
USA Fibromyalgia Association pilot grant ($55K)
~$3M contract research on neuroimmune targeted therapies for pharmaceutical companies such as Phebra, Bionomics, Avigen, Covidien, Implicit Biosciences, NovImmune, Merck and J&J.

I regularly teach into continuing medical education courses for Medical Colleges, Faculties and Societies.

I also teach into several University of Adelaide undergraduate courses as an invited specialist lecturer

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2022	Co-Supervisor	Oxidative stress activated prodrugs	Master of Philosophy	Master	Full Time	Mr Ravindu Ranasinghe
2022	Principal Supervisor	The Human Integrated Sensor System (HISS) Challenge	Doctor of Philosophy	Doctorate	Full Time	Mr Michail Laoumtzis
2021	Principal Supervisor	Exploring the neurobiological bases of affective states	Doctor of Philosophy	Doctorate	Full Time	Ms Jane Cerina Morphett
2021	Principal Supervisor	Regulation of the neuro-immune system	Doctor of Philosophy	Doctorate	Full Time	Mr Benjamin Daniel Barry
2021	Co-Supervisor	Effectiveness of Exercise to Improve Patient-Reported and Central Pain Modulation Outcomes in Chronic Neck Pain	Doctor of Philosophy	Doctorate	Full Time	Mr Kexun Kenneth Chen
2021	Principal Supervisor	Quantification of the lifetime experience of pain in livestock and its implications on productivity and animal husbandry practices, including applications to human health and wellbeing	Doctor of Philosophy	Doctorate	Full Time	Miss Charlotte Helen Johnston
2021	Co-Supervisor	Assessing the effects of glycosylation on mu- and delta- opioid receptor function and heteromerization.	Master of Philosophy (Medical Science)	Master	Full Time	Miss Kariel Renee Siemens
2021	Co-Supervisor	The physiological impacts of virtual fencing on sheep and cattle in South Australia.	Doctor of Philosophy	Doctorate	Part Time	Miss Megan Beth Willis
2020	Principal Supervisor	Immunophenotyping of Spinal Cord Injured Patients – Advancing Diagnostics and Prognostics.	Doctor of Philosophy	Doctorate	Part Time	Mr James Edward Swift
2019	Principal Supervisor	Investigating the effects of human mesenchymal stem cells and conditioned media (secretome) for the treatment of pain and neuropathic pain.	Doctor of Philosophy	Doctorate	Full Time	Mr Chrysostomos Constantine Maoudis

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2019 - 2019	Principal Supervisor	Peripheral-to-Central Neuroimmune Communication and the Sun: Implications for Addiction and Neurodegenerative Disease Pathology	Master of Philosophy (Medical Science)	Master	Full Time	Ms Krystal Lee Iacopetta
2018 - 2022	Co-Supervisor	Assessing Pain and Treatment Responsiveness in a Patient Cohort and Mouse Model of Inflammatory Arthritis Using Neurobiophotonics	Doctor of Philosophy	Doctorate	Full Time	Miss Florence Jade Lees
2016 - 2020	Principal Supervisor	The Role of Nitroxyl in the Development of Neuropathic Pain	Doctor of Philosophy	Doctorate	Full Time	Mrs Vicky Staikopoulos
2015 - 2020	Principal Supervisor	Advanced Preclinical Assessment of Hyper-Nociception	Doctor of Philosophy	Doctorate	Full Time	Mr Azim Arman
2015 - 2020	Principal Supervisor	Investigation of a Functional Relationship Between Toll-Like Receptor 4 and Transient Receptor Potential Cation Channel Subfamily V Member 1 in Relation to a Novel Neuroimmune Pain Model	Doctor of Philosophy	Doctorate	Full Time	Samuel Greig Evans
2014 - 2022	Principal Supervisor	Experimental Models of Alcohol Induced Inflammation-associated Depressive-like Behaviour	Doctor of Philosophy	Doctorate	Part Time	Joshua Luke Holmes
2014 - 2019	Principal Supervisor	From the Bottom Up: Chemotherapy-Induced Gut Toxicity, Glial Reactivity and Cognitive Impairment	Doctor of Philosophy	Doctorate	Part Time	Dr Juliana Esma Bajic
2014 - 2017	Principal Supervisor	Exploring the Bidirectional Interface between Stress and Innate Immunity: A Focus on Glucocorticoid and TLR4-MyD88 Signalling	Doctor of Philosophy	Doctorate	Full Time	Dr Jiajun Liu
2014 - 2019	Co-Supervisor	An optical fibre point temperature sensor for investigation of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') induced hyperthermia in the rat brain	Doctor of Philosophy	Doctorate	Full Time	Mr Stefan Tyrone Musolino
2014 - 2018	Principal Supervisor	Exploring the Role of Spinal Glia and Toll-Like Receptor 4 in the Development of Endometriosis and Neuroimmune-Associated Pain	Doctor of Philosophy	Doctorate	Full Time	Kelsi Nicole Dodds
2014 - 2018	Co-Supervisor	Investigating the role of Toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury	Doctor of Philosophy	Doctorate	Full Time	Sam Man Lee
2013 - 2017	Co-Supervisor	Toll-Like Receptor 4 Signalling in Inflammation Pathways to Term and Preterm Delivery	Doctor of Philosophy	Doctorate	Full Time	Miss Hanan Hamimi Binti Wahid
2013 - 2017	Principal Supervisor	Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours	Doctor of Philosophy	Doctorate	Full Time	Jonathan Henry Jacobsen
2011 - 2017	Principal Supervisor	Neuroimmunopharmacology of Opioids	Doctor of Philosophy	Doctorate	Full Time	Dr Jacob Henry Lloyd Thomas
2010 - 2014	Co-Supervisor	Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine	Doctor of Philosophy	Doctorate	Full Time	Mr Yibai Li
2010 - 2015	Co-Supervisor	Codeine, heightened pain sensitivity and medication overuse headache: A neuroimmune hypothesis and novel treatment strategy.	Doctor of Philosophy	Doctorate	Full Time	Miss Jacinta Lee Johnson
2010 - 2015	Principal Supervisor	Sex Differences in Allodynia: A complex Interaction Between 17beta-Oestradiol and the Innate Immune System	Doctor of Philosophy	Doctorate	Full Time	Miss Lauren Louise Nicotra
2010 - 2015	Co-Supervisor	The thermal grill as a tool to investigate analgesic clinical pharmacology	Doctor of Philosophy	Doctorate	Full Time	Mrs Nicole Martha Sumracki
2009 - 2011	Co-Supervisor	CNS Immune Signalling and Drug Addiction: Role of Interleukin-1 Beta	Doctor of Philosophy	Doctorate	Full Time	Mr Liang Liu
2009 - 2014	Co-Supervisor	Potential peripheral biomarkers for chronic pain	Doctor of Philosophy	Doctorate	Full Time	Miss Yuen Kwok
2008 - 2011	Co-Supervisor	The Neuroimmunopharmacology of Alcohol	Doctor of Philosophy	Doctorate	Full Time	Miss Yue Wu
2007 - 2011	Co-Supervisor	Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy	Doctor of Philosophy	Doctorate	Full Time	Mr Peter Grace

Board Memberships

Date Role Board name Institution name Country
2013 - ongoing Board Member Science Technology Australia - Australia

Date	Role	Board name	Institution name	Country
2013 - ongoing	Board Member	Science Technology Australia	-	Australia

Memberships

Date	Role	Membership	Country
2012 - ongoing	Member	Australian Pain Society	Australia
2007 - ongoing	Member	International Association for the Study of Pain	United States
2007 - ongoing	Member	Psychoneuroimmunology Research Society	United States
2002 - ongoing	Member	Society for Neuroscience	United States
1999 - ongoing	Representative	Australasian Society for Clinical and Experimental Pharmacology and Toxicology	Australia

Editorial Boards

Date Role Editorial Board Name Institution Country
2015 - ongoing Associate Editor Brain, Behavior, and Immunity - -

Date	Role	Editorial Board Name	Institution	Country
2015 - ongoing	Associate Editor	Brain, Behavior, and Immunity	-	-

Position: Director - Centre for Nanoscale BioPhotonics
Phone: 83130322
Email: mark.hutchinson@adelaide.edu.au
Fax: 82240685
Campus: North Terrace
Building: Helen Mayo South, floor Fifth Floor
Org Unit: Medical Sciences