Mark Hutchinson

Professor Mark Hutchinson

Director - Centre for Nanoscale BioPhotonics

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Mark Hutchinson is a Professor within the Adelaide Medical School and is the Director of the ARC Centre of Excellence for Nanoscale BioPhotonics.

Professor Hutchinson returned to the University of Adelaide in 2009 as an NHMRC CJ Martin Research Fellow, and established the Neuroimmunopharmacology research laboratory. From 2005 to 2009 Mark worked in the world leading laboratory of Prof Linda Watkins in the Center for Neuroscience at the University of Colorado, Boulder USA. Here he pioneered with Prof Watkins the research which has led to the discovery of a novel drug activity in innate immune receptors.

Mark’s research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments.

Mark has published over 170 papers in journals and refereed conference proceedings.

The CNBP is an ARC Centre of Excellence with $38M of funding committed for 7 years, headquartered at The University of Adelaide, with nodes at Macquarie University, Sydney; the RMIT, Melbourne; and Griffith University, the Gold Coast. We are partnered with universities and companies in Europe, the US and China, as well as other  Australian institutions.  

The CNBP has a mission to "Discover new approaches to measure nano-scale dynamic phenomena in living systems".  

I have several openings for research projects within my team for PhD students

Project 1
Title: Cell-based biomarker of persistent pain in livestock
Description: This project will translate a human biomarker of pain into the livestock setting to predict the chronic pain of animal husbandry practices.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2022
Special requirements: surgical skills, cell culture experience and some bioinformatics

Project 2
Title: Transcriptome biomarker of persistent pain in livestock
Description: This project will translate a human biomarker of pain into the livestock setting to predict the chronic pain of animal husbandry practices.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2022
Special requirements: surgical skills, bioinformatics and molecular techniques.

Project 3
Title: Modeling persistent pain in livestock
Description: This project will translate a human model of neuroimmune pain into the livestock setting to better predict the consequences of chronic pain in livestock and allow the development of novel pain therapies.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2022
Special requirements: surgical skills, animal handling experience and molecular techniques.

Project 4
Title: Drug discovery for novel treatments of persistent pain in livestock
Description: This project will translate neuroimmune pain targeted treatments into the livestock setting to better treat chronic pain in livestock and allow the development of deployable pain therapies.
Project available for: HDR and/or Honours
Location: Roseworthy and North Tce
Research Project start date: Semester 1 2022
Special requirements: surgical skills, animal handling experience and molecular pharmacology techniques.

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  • Journals

    Year Citation
    2021 Arman, A., & Hutchinson, M. R. (2021). Intrathecal implantation surgical considerations in rodents; a review. Journal of Neuroscience Methods, 363, 1-6.
    DOI
    2021 Gosnell, M. E., Staikopoulos, V., Anwer, A. G., Mahbub, S. B., Hutchinson, M. R., Mustafa, S., & Goldys, E. M. (2021). Autofluorescent imprint of chronic constriction nerve injury identified by deep learning. Neurobiology of Disease, 160, 105528.
    DOI
    2021 George, R., Semendric, I., Hutchinson, M., & Whittaker, A. (2021). Neuroimmune reactivity marker expression in rodent models of chemotherapy-induced cognitive impairment: a systematic scoping review. Brain, Behavior, and Immunity, 94, 392-409.
    DOI Scopus1 WoS1
    2021 Staikopoulos, V., Qiao, S., Liu, J., Song, X., Yang, X., Luo, Q., . . . Zhang, Z. (2021). Graded peripheral nerve injury creates mechanical allodynia proportional to the progression and severity of microglial activity within the spinal cord of male mice. Brain, Behavior, and Immunity, 91, 568-577.
    DOI Scopus1 Europe PMC1
    2021 Grace, P. M., Tawfik, V. L., Svensson, C. I., Burton, M. D., Loggia, M. L., & Hutchinson, M. R. (2021). The neuroimmunology of chronic pain: from rodents to humans. The Journal of Neuroscience, 41(5), 855-865.
    DOI Scopus6 WoS4 Europe PMC3
    2021 Ribarovska, A. K., Hutchinson, M. R., Pittman, Q. J., Pariante, C., & Spencer, S. J. (2021). Gender inequality in publishing during the COVID-19 pandemic. Brain, Behavior, and Immunity, 91, 1-3.
    DOI Scopus4 WoS2 Europe PMC3
    2021 Bajic, J., Howarth, G., Mashtoub, S., Whittaker, A., Bobrovskaya, L., & Hutchinson, M. R. (2021). Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats. Journal of Neuroscience Research, 1-14.
    DOI
    2021 Zhang, T., Zhang, X., Lin, C., Wu, S., Wang, F., Wang, H., . . . Wang, X. (2021). Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood–brain barrier leakage in mice. Journal of Neurochemistry, 157(3), 611-623.
    DOI Scopus4 Europe PMC1
    2021 Evans, S. F., Kwok, Y., Solterbeck, A., Pyragius, C., Hull, M. L., Hutchinson, M. R., & Rolan, P. (2021). The relationship between androgens and days per month of period pain, pelvic pain, headache, and TLR4 responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhoea. Journal of Pain Research, 14, 585-599.
    DOI
    2021 Li, H., Peng, Y., Lin, C., Zhang, X., Zhang, T., Wang, Y., . . . Wang, X. (2021). Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling. The Innovation, 2(2), 100111-1-100111-8.
    DOI Scopus1
    2021 Marsh, L., Hutchinson, M., McLaughlan, C., Musolino, S., Hebart, M. L., Terry, R., . . . Whittaker, A. (2021). Evaluation of miRNA as biomarkers of emotional valence in pigs. Animals, 7(7), 1-19.
    DOI Scopus1
    2021 Lin, C., Wang, H., Zhang, M., Mustafa, S., Wang, Y., Li, H., . . . Wang, X. (2021). TLR4 biased small molecule modulators. Pharmacology and Therapeutics, 228, 107918.
    DOI
    2021 Williams, B., Lees, F., Tsangari, H., Hutchinson, M. R., Perilli, E., & Crotti, T. N. (2021). Effects of mild and moderate monoclonal antibody dose on inflammation, bone loss, and activation of the central nervous system in a female collagen antibody-induced arthritis mouse model. Journal of Histochemistry and Cytochemistry, 69(8), 511-522.
    DOI
    2020 Doyle, T. M., Hutchinson, M. R., Braden, K., Janes, K., Staikopoulos, V., Chen, Z., . . . Salvemini, D. (2020). Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents. Journal of Neuroinflammation, 17(1), 8 pages.
    DOI Europe PMC1
    2020 Zabolocki, M., McCormack, K., van den Hurk, M., Milky, B., Shoubridge, A. P., Adams, R., . . . Bardy, C. (2020). BrainPhys neuronal medium optimized for imaging and optogenetics in vitro. Nature Communications, 11(1), 1-19.
    DOI Scopus2 WoS1 Europe PMC1
    2020 Doyle, T. M., Largent-Milnes, T. M., Chen, Z., Staikopoulos, V., Esposito, E., Delgarno, R., . . . Salvemini, D. (2020). Chronic morphine-induced changes in signaling at the A3 adenosine receptor contribute to morphine-induced hyperalgesia, tolerance and withdrawal. The Journal of pharmacology and experimental therapeutics, 374(2), 331-341.
    DOI Scopus13 WoS8 Europe PMC10
    2020 Frank, M. G., Baratta, M. V., Zhang, K., Fallon, I. P., Pearson, M. A., Liu, G., . . . Maier, S. F. (2020). Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus. Brain, Behavior, and Immunity, 90, 70-80.
    DOI Scopus1 WoS2 Europe PMC1
    2020 Evans, S. F., Kwok, Y. H., Solterbeck, A., Liu, J., Hutchinson, M. R., Hull, M. L., & Rolan, P. E. (2020). Toll-like receptor responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhea. Journal of Pain Research, 13, 503-516.
    DOI Scopus2 WoS2 Europe PMC2
    2020 Williams, B., Lees, F., Tsangari, H., Hutchinson, M. R., Perilli, E., & Crotti, T. N. (2020). Assessing the effects of parthenolide on inflammation, bone loss, and glial cells within a collagen antibody-Induced arthritis mouse model. Mediators Inflamm, 2020, 6245798.
    DOI Scopus2 WoS3 Europe PMC3
    2020 Borrachero-Conejo, A. I., Adams, W. R., Saracino, E., Mola, M. G., Wang, M., Posati, T., . . . Benfenati, V. (2020). Stimulation of water and calcium dynamics in astrocytes with pulsed infrared light.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6539-6553.
    DOI Scopus7 WoS7 Europe PMC3
    2020 Chia, J. S. M., Izham, N. A. M., Farouk, A. A. O., Sulaiman, M. R., Mustafa, S., Hutchinson, M. R., & Perimal, E. K. (2020). Zerumbone Modulates α<inf>2A</inf>-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models. Frontiers in Pharmacology, 11, 92.
    DOI Scopus5 WoS4 Europe PMC3
    2020 Wang, Y., Zhang, S., Li, H., Wang, H., Zhang, T., Hutchinson, M. R., . . . Wang, X. (2020). Small-molecule modulators of toll-like receptors. Accounts of Chemical Research, 53(3), 1046-1055.
    DOI Scopus19 WoS17 Europe PMC8
    2020 Arman, A., Deng, F., Goldys, E. M., Liu, G., & Hutchinson, M. R. (2020). In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain. Brain, Behavior, and Immunity, 88, 442-450.
    DOI Scopus4 WoS4 Europe PMC1
    2020 Robertson, S. A., Hutchinson, M. R., Rice, K. C., Chin, P. -Y., Moldenhauer, L. M., Stark, M. J., . . . Keelan, J. A. (2020). Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury. Clinical and Translational Immunology, 9(4), e1121-1-e1121-19.
    DOI WoS5 Europe PMC4
    2020 Kelley, K. W., Peng, Y. P., Liu, Q., Chang, H. C., Spencer, S. J., Hutchinson, M. R., & Shimada, A. (2020). Psychoneuroimmunology goes East: Development of the PNIRSChina affiliate and its expansion into PNIRSAsia-Pacific. Brain, Behavior, and Immunity, 88, 75-87.
    DOI
    2020 Hutchinson, M. R. (2020). Science convergence applied to psychoneuroimmunology: the future of measurement and imaging. Brain, Behavior, and Immunity, 88, 262-269.
    DOI
    2020 Deng, F., Arman, A., Goldys, E. M., Hutchinson, M. R., & Liu, G. (2020). A Method for in Vivo Quantification of Cytokine IL-1β in the Rat Intrathecal Space. ACS Applied Bio Materials, 3(1), 539-546.
    DOI Scopus4
    2020 Wahid, H. H., Chin, P. Y., Sharkey, D. J., Diener, K. R., Hutchinson, M. R., Rice, K. C., . . . Robertson, S. A. (2020). Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. American Journal of Pathology, 190(5), 1030-1045.
    DOI Scopus3 WoS2 Europe PMC3
    2020 Khalid, A., Peng, L., Arman, A., Warren-Smith, S., Schartner, E., Sylvia, G., . . . Li, J. (2020). Silk: a bio-derived coating for optical fiber sensing applications. Sensors and Actuators B: Chemical, 311, 127864-1-127864-8.
    DOI Scopus9 WoS8
    2020 Liddicoat, C., Sydnor, H., Cando-Dumancela, C., Dresken, R., Liu, J., Gellie, N., . . . Breed, M. (2020). Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice. Science of the Total Environment, 701, 1-11.
    DOI Scopus38 WoS34
    2020 Iqbal, S., Parker, L. M., Everest-Dass, A., Moh, E. S. X., Sayyadi, N., Hutchinson, M. R., & Packer, N. H. (2020). Lipopolysaccharide and morphine-3-glucuronide-induced immune signalling increases the expression of polysialic acid in PC12 cells. Molecular Neurobiology, 57(2), 964-975.
    DOI
    2020 Iacopetta, K., Collins-Praino, L. E., Buisman-Pijlman, F., Liu, J., Hutchinson, A., & Hutchinson, M. R. (2020). Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review. Nutritional Neuroscience, 23(4), 251-280.
    DOI Scopus7 WoS6 Europe PMC2
    2019 Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2019). Spinal glial adaptations occur in a minimally invasive mouse model of endometriosis: potential implications for lesion etiology and persistent pelvic pain. Reproductive Sciences, 26(3), 1-13.
    DOI Scopus8 WoS6 Europe PMC5
    2019 Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., . . . Wang, X. (2019). Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9577-9587.
    DOI Scopus10 WoS7 Europe PMC2
    2019 Liu, G., Bursill, C., Cartland, S. P., Anwer, A. G., Parker, L. M., Zhang, K., . . . Goldys, E. M. (2019). A nanoparticle-based affinity sensor that identifies and selects highly cytokine-secreting cells. iScience, 20, 137-147.
    DOI Scopus7 WoS8 Europe PMC2
    2019 Musolino, S., Schartner, E., Hutchinson, M., & Salem, A. (2019). Minocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain. European Journal of Pharmacology, 858, 172495-1-172495-10.
    DOI Scopus1 WoS1
    2019 Hutchinson, M. R., & Terry, R. (2019). Review: What innovations in pain measurement and control might be possible if we could quantify the neuroimmune synapse?. Animal, 13(12), 3000-3008.
    DOI Scopus1 WoS1
    2019 Chin, P. Y., Dorian, C., Sharkey, D. J., Hutchinson, M. R., Rice, K. C., Moldenhauer, L. M., & Robertson, S. A. (2019). Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology, 160(11), 2646-2662.
    DOI Scopus4 WoS5 Europe PMC5
    2019 Peng, Y., Zhang, X., Zhang, T., Grace, P. M., Li, H., Wang, Y., . . . Wang, X. (2019). Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity, 82, 432-444.
    DOI Scopus13 WoS10 Europe PMC3
    2019 Wang, X., Northcutt, A. L., Cochran, T. A., Zhang, X., Fabisiak, T. J., Haas, M. E., . . . Watkins, L. R. (2019). Methamphetamine activates toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. ACS Chemical Neuroscience, 10(8), 3622-3634.
    DOI Scopus25 WoS21 Europe PMC13
    2019 Zhang, K., Arman, A., Anwer, A., Hutchinson, M., & Goldys, E. (2019). An optical fiber based immunosensor for localized detection of IL-1β in rat spinal cord. Sensors and Actuators, B: Chemical, 282, 122-129.
    DOI Scopus7 WoS5
    2019 Musolino, S. T., Schartner, E. P., Hutchinson, M. R., & Salem, A. (2019). Improved method for optical fiber temperature probe implantation in brains of free-moving rats. Journal of Neuroscience Methods, 313, 24-28.
    DOI Scopus4 WoS5
    2019 Parker, L. M., Sayyadi, N., Staikopoulos, V., Shrestha, A., Hutchinson, M. R., & Packer, N. H. (2019). Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization. Journal of Neuroinflammation, 16(1), 65-1-65-13.
    DOI Scopus5 WoS4 Europe PMC2
    2019 Heng, S., Zhang, X., Pei, J., Adwal, A., Reineck, P., Gibson, B. C., . . . Abell, A. D. (2019). Spiropyran-based nanocarrier: a new Zn²⁺-responsive delivery system with real-time intracellular sensing capabilities. Chemistry - A European Journal, 25(3), 854-862.
    DOI Scopus8 WoS8 Europe PMC1
    2018 Hutchinson, M. R., Stoddart, P. R., & Mahadevan-Jansen, A. (2018). Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017. Neurophotonics, 5(4), 1-5.
    DOI Scopus4 WoS3
    2018 Iacopetta, K., Collins-Praino, L., Buisman-Pijlman, F., & Hutchinson, M. (2018). Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?. Brain, Behavior, and Immunity, 73, 125-132.
    DOI Scopus1
    2018 Li, J., Ebendorff-Heidepriem, H., Gibson, B., Greentree, A. D., Hutchinson, M., Jia, P., . . . Goldys, E. M. (2018). Perspective: biomedical sensing and imaging with optical fibers - innovation through convergence of science disciplines. APL Photonics, 3(10), 1-20.
    DOI Scopus20 WoS22
    2018 Cao, C., Jin, R., Wei, H., Yang, W., Goldys, E. M., Hutchinson, M. R., . . . Liu, G. (2018). Graphene oxide based recyclable in vivo device for amperometric monitoring of interferon-γ in inflammatory mice. ACS Applied Materials and Interfaces, 10(39), 33078-33087.
    DOI Scopus14 WoS15 Europe PMC4
    2018 Hutchinson, M. R. (2018). GLIA AND PAIN. SCIENTIST, 32(1), 34-41.
    2018 Zhang, K., Baratta, M., Liu, G., Frank, M., Leslie, N., Watkins, L., . . . Goldys, E. (2018). A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity, 71, 18-22.
    DOI Scopus18 WoS19 Europe PMC4
    2018 Hutchinson, M. R. (2018). ‘Convergence’ created psychoneuroimmunology, and is needed again to secure the future of the field. Brain, Behavior, and Immunity, 71, 1-2.
    DOI Scopus2 WoS2 Europe PMC1
    2018 Bajic, J., Johnston, I., Howarth, G., & Hutchinson, M. (2018). From the bottom-up: chemotherapy and gut-brain axis dysregulation. Frontiers in Behavioral Neuroscience, 12, 104-1-104-16.
    DOI Scopus30 WoS27 Europe PMC17
    2018 Hutchinson, M. (2018). The importance of knowing you are sick: nanoscale biophotonics for the 'other' brain. Microelectronic Engineering, 187-188, 101-104.
    DOI Scopus4 WoS4
    2018 Marcu, L., Boppart, S., Hutchinson, M., Popp, J., & Wilson, B. (2018). Biophotonics: The big picture. Journal of Biomedical Optics, 23(2), 1-7.
    DOI Scopus13 WoS14 Europe PMC3
    2018 Hutchinson, M. R. (2018). Glial ties to persistent pain : Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain. Scientist, 32(1), 34-41.
    2018 Liu, J., Mustafa, S., Barratt, D., & Hutchinson, M. (2018). Corticosterone preexposure increases NF-κB translocation and sensitizes IL-1β responses in BV2 microglia-like cells. Frontiers in Immunology, 9(JAN), 1-12.
    DOI Scopus10 WoS8 Europe PMC6
    2018 Robertson, S., Wahid, H., Chin, P., Hutchinson, M., Moldenhauer, L., & Keelan, J. (2018). Toll-like receptor-4: A new target for preterm labour pharmacotherapies?. Current Pharmaceutical Design, 24(9), 960-973.
    DOI Scopus13 WoS15 Europe PMC10
    2018 Zhang, X., Cui, F., Chen, H., Zhang, T., Yang, K., Wang, Y., . . . Wang, X. (2018). Dissecting the innate immune recognition of opioid inactive isomer (+)-naltrexone derived toll-like receptor 4 (TLR4) antagonists. Journal of Chemical Information and Modeling, 58(4), 816-825.
    DOI Scopus19 WoS16 Europe PMC10
    2018 Beckett, E., Staikopoulos, V., & Hutchinson, M. (2018). Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice. Scientific Reports, 8(1), 5923-1-5923-13.
    DOI Scopus5 WoS5 Europe PMC2
    2018 Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity, 67, 181-193.
    DOI Scopus6 WoS6 Europe PMC3
    2018 Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology, 128, 460-473.
    DOI Scopus7 WoS7 Europe PMC2
    2017 Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). Sensitive cytokine assay based on optical fiber allowing localized and spatially resolved detection of interleukin-6. ACS Sensors, 2(2), 218-226.
    DOI Scopus20 WoS19 Europe PMC4
    2017 Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2017). Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis. Biology of Reproduction, 97(6), 810-821.
    DOI Scopus10 WoS10 Europe PMC7
    2017 Zohora, N., Kandjani, A., Orth, A., Brown, H., Hutchinson, M., & Gibson, B. (2017). Fluorescence brightness and photostability of individual copper (I) oxide nanocubes. Scientific Reports, 7(1), 16905-1-16905-8.
    DOI Scopus5 WoS3 Europe PMC1
    2017 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopy. Applied Spectroscopy Reviews, 52(5), 439-455.
    DOI Scopus11 WoS9
    2017 Johnston, I., Tan, M., Cao, J., Matsos, A., Forrest, D., Si, E., . . . Hutchinson, M. (2017). Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats. Behavioural Brain Research, 334, 109-118.
    DOI Scopus9 WoS10 Europe PMC6
    2017 Liu, G., Zhang, K., Ma, K., Care, A., Hutchinson, M., & Goldys, E. (2017). Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring. Nanoscale, 9(15), 4934-4943.
    DOI Scopus26 WoS24 Europe PMC4
    2017 Lewis, S., Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2017). Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity, 64, 59-64.
    DOI Scopus2 WoS2 Europe PMC1
    2016 Jacobsen, J., Parker, L., Everest-Dass, A., Schartner, E., Tsiminis, G., Staikopoulos, V., . . . Mustafa, S. (2016). Novel imaging tools for investigating the role of immune signalling in the brain. Brain, Behavior, and Immunity, 58, 40-47.
    DOI Scopus11 WoS10 Europe PMC3
    2016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Coller, J., White, I., . . . Bowen, J. (2016). Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics, 15(6), 1376-1386.
    DOI Scopus57 WoS54 Europe PMC31
    2016 Lee, S., Hutchinson, M., & Saint, D. (2016). The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology and Physiology, 43(9), 864-871.
    DOI Scopus17 WoS17 Europe PMC12
    2016 Chalmers, K., Madden, V., Hutchinson, M., & Moseley, G. (2016). Local and systemic inflammation in localized, provoked vestibulodynia. Obstetrics and Gynecology, 128(2), 337-347.
    DOI Scopus12 WoS11 Europe PMC6
    2016 Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). Portable optical fiber probe for in vivo brain temperature measurements. Biomedical Optics Express, 7(8), 3069-3078.
    DOI Scopus34 WoS30 Europe PMC4
    2016 Ellis, A., Grace, P., Wieseler, J., Favret, J., Springer, K., Skarda, B., . . . Watkins, L. (2016). Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity, 58, 348-356.
    DOI Scopus40 WoS37 Europe PMC28
    2016 Dodds, K., Beckett, E., Evans, S., Grace, P., Watkins, L., & Hutchinson, M. (2016). Glial contributions to visceral pain : implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry, 6(9), e888-1-e888-13.
    DOI Scopus25 WoS27 Europe PMC20
    2016 Somogyi, A., Sia, A., Tan, E., Coller, J., Hutchinson, M., & Barratt, D. (2016). Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain, 157(11), 2458-2466.
    DOI Scopus15 WoS14 Europe PMC9
    2016 Chin, P., Dorian, C., Hutchinson, M., Olson, D., Rice, K., Moldenhauer, L., & Robertson, S. (2016). Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports, 6(1), 36112-1-36112-13.
    DOI Scopus38 WoS33 Europe PMC27
    2016 Grace, P., Gaudet, A., Staikopoulos, V., Maier, S., Hutchinson, M., Salvemini, D., & Watkins, L. (2016). Nitroxidative signaling mechanisms in pathological pain. Trends in Neurosciences, 39(12), 862-879.
    DOI Scopus55 WoS51 Europe PMC31
    2016 Gibson, R., Coller, J., Wardill, H., Hutchinson, M., Smid, S., & Bowen, J. (2016). Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer, 24(5), 2251-2258.
    DOI Scopus15 WoS15 Europe PMC4
    2016 Wang, X., Zhang, Y., Peng, Y., Hutchinson, M., Rice, K., Yin, H., & Watkins, L. (2016). Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. British Journal of Pharmacology, 173(5), 856-869.
    DOI Scopus82 WoS74 Europe PMC53
    2016 Jacobsen, J., Hutchinson, M., & Mustafa, S. (2016). Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology, 26, 131-137.
    DOI Scopus20 WoS21 Europe PMC11
    2016 Liu, G., Qi, M., Hutchinson, M., Yang, G., & Goldys, E. (2016). Recent advances in cytokine detection by immunosensing. Biosensors and Bioelectronics, 79, 810-821.
    DOI Scopus79 WoS77 Europe PMC26
    2015 Ingman, W., Glynn, D., & Hutchinson, M. (2015). Mouse models of mastitis - how physiological are they?. International Breastfeeding Journal, 10(1), 12-1-12-5.
    DOI Scopus10 WoS10 Europe PMC9
    2015 Lee, S., Hutchinson, M., Staikopoulos, V., & Saint, D. (2015). Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. International Journal of Cardiology, 190, 353-359.
    DOI Scopus8 WoS7 Europe PMC5
    2015 Wahid, H., Dorian, C., Chin, P., Hutchinson, M., Rice, K., Olson, D., . . . Robertson, S. (2015). Toll-like receptor 4 Is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology, 156(10), 3828-3841.
    DOI Scopus37 WoS33 Europe PMC24
    2015 Bachtell, R., Hutchinson, M., Wang, X., Rice, K., Maier, S., & Watkins, L. (2015). Targeting the toll of drug abuse: the translational potential of toll-like receptor 4. CNS and Neurological Disorders - Drug Targets, 14(6), 692-699.
    DOI Scopus47 WoS43 Europe PMC30
    2015 Johnson, J. L., Kwok, Y. H., Sumracki, N. M., Swift, J. E., Hutchinson, M. R., Johnson, K., . . . Rolan, P. E. (2015). Glial attenuation with ibudilast in the treatment of medication overuse headache: a double-blind, randomized, placebo-controlled pilot trial of efficacy and safety. Headache, 55(9), 1192-1208.
    DOI Scopus11 WoS10 Europe PMC7
    2015 Corrigan, F., Wu, Y., Tuke, J., Coller, J., Rice, K., Diener, K., . . . Hutchinson, M. (2015). Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity, 45, 245-252.
    DOI Scopus16 WoS16 Europe PMC15
    2015 Northcutt, A., Hutchinson, M., Wang, X., Baratta, M., Hiranita, T., Cochran, T., . . . Watkins, L. (2015). DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry, 20(12), 1525-1537.
    DOI Scopus114 WoS103 Europe PMC69
    2015 Li, Y., Jackson, K., Slon, B., Hardy, J., Franco, M., William, L., . . . Somogyi, A. (2015). CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects. British Journal of Clinical Pharmacology, 80(2), 276-284.
    DOI Scopus33 WoS30 Europe PMC21
    2015 Lewis, S., Hutchinson, M., Frick, M., Zhang, Y., Maier, S., Sammakia, T., . . . Watkins, L. (2015). Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity, 44, 128-136.
    DOI Scopus10 WoS10 Europe PMC5
    2014 Liu, J., Buisman-Pijlman, F., & Hutchinson, M. (2014). Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder. Frontiers in Neuroscience, 8(SEP), 309-1-309-15.
    DOI Scopus65 WoS57 Europe PMC42
    2014 Jacobsen, J., Watkins, L., & Hutchinson, M. (2014). Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology, 118, 129-163.
    DOI Scopus38 WoS30 Europe PMC28
    2014 Hutchinson, M. R. (2014). Want more pain? Just add a dash of endotoxin to enhance your clinical pain model. Brain, Behavior, and Immunity, 41(1), 44-45.
    DOI Scopus7 WoS7 Europe PMC5
    2014 Watkins, L. R., & Hutchinson, M. R. (2014). A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: Comment on Smith and Dragunow. Trends in Neurosciences, 37(4), 189-190.
    DOI Scopus10 WoS9 Europe PMC4
    2014 Johnson, J., Rolan, P., Johnson, M., Bobrovskaya, L., Williams, D., Johnson, K., . . . Hutchinson, M. (2014). Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry, 4(11), e482-1-e482-9.
    DOI Scopus21 WoS21 Europe PMC17
    2014 Grace, P., Ramos, K., Rodgers, K., Wang, X., Hutchinson, M., Lewis, M., . . . Watkins, L. (2014). Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience, 280, 299-317.
    DOI Scopus43 WoS43 Europe PMC34
    2014 Nicotra, L., Tuke, S., Grace, P., Rolan, P., & Hutchinson, M. (2014). Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?. Frontiers in Behavioral Neuroscience, 8(February), 1-16.
    DOI Scopus26 WoS24 Europe PMC16
    2014 Sumracki, N., Buisman-Pijlman, F., Hutchinson, M., Gentgall, M., & Rolan, P. (2014). Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine, 15(4), 647-660.
    DOI Scopus10 WoS9 Europe PMC6
    2014 Narayan, D., Casson, R., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Wood, J. (2014). Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. Clinical and Experimental Ophthalmology, 42(6), 539-554.
    DOI Scopus3 WoS1
    2014 Glynn, D., Hutchinson, M., & Ingman, W. (2014). Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction, 90(5), 1-11.
    DOI Scopus21 WoS21 Europe PMC14
    2014 Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2014). Pathological pain and the neuroimmune interface. Nature Reviews Immunology, 14(4), 217-231.
    DOI Scopus469 WoS457 Europe PMC331
    2014 Watkins, L. R., Wang, X., Mustafa, S., & Hutchinson, M. R. (2014). In vivo veritas: (+)-Naltrexone's actions define translational importance. A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences, 35(9), 432-433.
    DOI Scopus11 WoS12 Europe PMC9
    2014 Ingman, W., Glynn, D., & Hutchinson, M. (2014). Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia, 19(2), 161-167.
    DOI Scopus30 WoS29 Europe PMC18
    2014 Zwicker, J., Zhang, Y., Ren, J., Hutchinson, M., Rice, K., Watkins, L., . . . Funk, G. (2014). Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology, 117(8), 857-868.
    DOI Scopus8 WoS9 Europe PMC6
    2014 Mulholland, C., Somogyi, A., Barratt, D., Coller, J., Hutchinson, M., Jacobson, G., . . . Sleigh, J. (2014). Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia. Journal of Molecular Neuroscience, 52(4), 497-506.
    DOI Scopus10 WoS8 Europe PMC6
    2014 Hutchinson, M., & Watkins, L. (2014). Why is neuroimmunopharmacology crucial for the future of addiction research?. Neuropharmacology, 76(Part B), 218-227.
    DOI Scopus68 WoS65 Europe PMC51
    2013 Thomas, J., & Hutchinson, M. R. (2013). Erratum: Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (Expert Review of Neurotherapeutics (2012) 12:11 (1311-1324)). Expert Review of Neurotherapeutics, 13(3), 339-340.
    DOI
    2013 Thomas, J., & Hutchinson, M. R. (2013). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (vol 12, pg 1311, 2012). EXPERT REVIEW OF NEUROTHERAPEUTICS, 13(3), 339-340.
    2013 Kwok, Y., Tuke, S., Nicotra, L., Grace, P., Rolan, P., & Hutchinson, M. (2013). TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. PLoS One, 8(10), 1-16.
    DOI Scopus11 WoS9 Europe PMC9
    2013 Della Vedova, C., Cathcart, S., Dohnalek, A., Lee, V., Hutchinson, M., Immink, M., & Hayball, J. (2013). Peripheral interleukin-1β levels are elevated in chronic tension-type headache patients. Pain Research & Management : The Journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur, 18(6), 301-306.
    DOI Scopus20 WoS15 Europe PMC9
    2013 Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Stanley, N., . . . Somogyi, A. (2013). The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition, 41(6), 1264-1272.
    DOI Scopus28 WoS27 Europe PMC19
    2013 Hutchinson, M., Bujis, M., Tuke, S., Kwok, Y., Gentgall, M., Williams, D., & Rolan, P. (2013). Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behavior and Immunity, 30, 3-11.
    DOI Scopus43 WoS39 Europe PMC22
    2013 Theberge, F., Li, X., Kambhampati, S., Pickens, C., St Laurent, R., Bossert, J., . . . Shaham, Y. (2013). Effect of chronic delivery of the toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry, 73(8), 729-737.
    DOI Scopus77 WoS73 Europe PMC64
    2013 Lewis, S., Hutchinson, M., Zhang, Y., Hund, D., Maier, S., Rice, K., & Watkins, L. (2013). Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behavior and Immunity, 30, 24-32.
    DOI Scopus34 WoS33 Europe PMC28
    2013 Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia, 33(1), 52-64.
    DOI Scopus33 WoS32 Europe PMC22
    2012 Jalleh, R., Koh, K., Choi, B., Liu, E., Maddison, J., & Hutchinson, M. (2012). Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Medical Hypotheses, 79(6), 735-739.
    DOI Scopus16 WoS12 Europe PMC8
    2012 Kwok, Y., Hutchinson, M., Gentgall, M., & Rolan, P. (2012). Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. PLoS One, 7(8), 1-8.
    DOI Scopus34 WoS33 Europe PMC24
    2012 Hutchinson, M., Northcutt, A., Hiranita, T., Wang, X., Lewis, S., Thomas, J., . . . Watkins, L. (2012). Opioid activation of toll-like receptor 4 contributes to drug reinforcement. Journal of Neuroscience, 32(33), 11187-11200.
    DOI Scopus186 WoS174 Europe PMC132
    2012 Grace, P., Hurley, D., Barratt, D., Tsykin, A., Watkins, L., Rolan, P., & Hutchinson, M. (2012). Harnessing pain heterogeneity and RNA transcriptome to idenitfy blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic construction injury model. Journal of Neurochemistry, 122(5), 976-994.
    DOI Scopus20 WoS16 Europe PMC13
    2012 Watkins, L., Hutchinson, M., & Johnson, K. (2012). Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology, 234(2), 351-353.
    DOI Scopus15 WoS16 Europe PMC16
    2012 Corrigan, F., & Hutchinson, M. (2012). Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling?. Expert Review of Clinical Immunology, 8(3), 201-203.
    DOI Scopus5 WoS3 Europe PMC3
    2012 Sumracki, N., Hutchinson, M., Gentgall, M., Briggs, N., Williams, D., & Rolan, P. (2012). The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One, 7(6), 1-8.
    DOI Scopus19 WoS17 Europe PMC12
    2012 Lewis, S., Loram, L., Hutchinson, M., Li, C., Zhang, Y., Maier, S., . . . Watkins, L. (2012). (+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain, 13(5), 498-506.
    DOI Scopus73 WoS69 Europe PMC56
    2012 Wang, X., Loram, L., Ramos, K., de Jesus, A., Thomas, J., Cheng, K., . . . Yin, H. (2012). Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6325-6330.
    DOI Scopus275 WoS274 Europe PMC201
    2012 Coller, J., & Hutchinson, M. (2012). Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & Therapeutics, 134(2), 219-245.
    DOI Scopus118 WoS109 Europe PMC84
    2012 Nicotra, L., Loram, L., Watkins, L., & Hutchinson, M. (2012). Toll-like receptors in chronic pain. Experimental Neurology, 234(2), 316-329.
    DOI Scopus165 WoS155 Europe PMC114
    2012 Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Coller, J., Rice, K., . . . Hutchinson, M. (2012). Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology, 165(5), 1319-1329.
    DOI Scopus62 WoS53 Europe PMC46
    2012 Thomas, J., & Hutchinson, M. (2012). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids. Expert Review of Neurotherapeutics, 12(11), 1311-1324.
    DOI Scopus9 WoS9 Europe PMC5
    2011 Schwarz, J., Hutchinson, M., & Bilbo, S. (2011). Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. The Journal of Neuroscience, 31(49), 17835-17847.
    DOI Scopus123 WoS117 Europe PMC94
    2011 Anderson, P., Hutchinson, M., Irvine, R., & Salem, A. (2011). Attenuating glial activation with minocycline reduces the hyperthermic response to 3, 4-methylenedioxymethamphetamine (MDMA) in the rat. The Open Addiction Journal, 4(Sp Iss), 4-5.
    DOI
    2011 Salem, A., Gordon, J., Hutchinson, M., & Irvine, R. (2011). 3,4-Methylenedioxymethamphetamine (MDMA) induced hyperthermia - the role of pro-inflammatory cytokines. The Open Addiction Journal, 4(Sp Iss), 48-49.
    DOI
    2011 Grace, P., Rolan, P., & Hutchinson, M. (2011). Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behavior and Immunity, 25(7), 1322-1332.
    DOI Scopus82 WoS80 Europe PMC64
    2011 Liu, L., Ghosh, N., Slivka, P., Fiorini, Z., Hutchinson, M., Watkins, L., & Yin, H. (2011). An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. ChemBioChem, 12(12), 1827-1831.
    DOI Scopus12 WoS10 Europe PMC8
    2011 Liu, L., Coller, J., Watkins, L., Somogyi, A., & Hutchinson, M. (2011). Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains. Brain Behavior and Immunity, 25(6), 1223-1232.
    DOI Scopus42 WoS40 Europe PMC35
    2011 Hutchinson, M., Shavit, Y., Grace, P., Rice, K., Maier, S., & Watkins, L. (2011). Exploring the neuroimmunopharmacology of opioids: An integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews, 63(3), 772-810.
    DOI Scopus273 WoS258 Europe PMC192
    2011 Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Robertson, S., Coller, J., . . . Hutchinson, M. (2011). Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behavior and Immunity, 25(Suppl 1), 155-164.
    DOI Scopus60 WoS48 Europe PMC37
    2011 Grace, P., Hutchinson, M., Bishop, A., Somogyi, A., Mayrhofer, G., & Rolan, P. (2011). Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain Behavior and Immunity, 25(3), 503-513.
    DOI Scopus15 WoS15 Europe PMC13
    2010 Grace, P., Hutchinson, M., Manavis, J., Somogyi, A., & Rolan, P. (2010). A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods, 193(1), 47-53.
    DOI Scopus31 WoS31 Europe PMC24
    2010 Joce, C., Stahl, J., Shridhar, M., Hutchinson, M., Watkins, L., Fedichev, P., & Yin, H. (2010). Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters, 20(18), 5411-5413.
    DOI Scopus32 WoS31 Europe PMC24
    2010 Stanley, N., Hutchinson, M., Kvist, T., Nielsen, B., Mathiesen, J., Brauner-Osborne, H., . . . Taylor, D. (2010). A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry, 18(16), 6089-6098.
    DOI Scopus4 WoS4
    2010 Buchanan, M., Hutchinson, M., Watkins, L., & Yin, H. (2010). Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry, 114(1), 13-27.
    DOI Scopus234 WoS226 Europe PMC155
    2010 Hutchinson, M., Zhang, Y., Shridhar, M., Evans, J., Buchanan, M., Zhao, T., . . . Watkins, L. (2010). Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behavior and Immunity, 24(1), 83-95.
    DOI Scopus344 WoS327 Europe PMC254
    2010 Lewis, S., Hutchinson, M., Rezvani, N., Loram, L., Zhang, Y., Maier, S., . . . Watkins, L. (2010). Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience, 165(2), 569-583.
    DOI Scopus117 WoS110 Europe PMC81
    2010 Hutchinson, M., Loram, L., Zhang, Y., Shridhar, M., Rezvani, N., Berkelhammer, D., . . . Watkins, L. (2010). Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience, 168(2), 551-563.
    DOI Scopus70 WoS61 Europe PMC44
    2010 Hutchinson, M., Lewis, S., Coats, B., Rezvani, N., Zhang, Y., Wieseler, J., . . . Watkins, L. (2010). Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience, 167(3), 880-893.
    DOI Scopus90 WoS80 Europe PMC72
    2009 Slivka, P., Shridhar, M., Lee, G., Sammond, D., Hutchinson, M., Martinko, A., . . . Yin, H. (2009). A Peptide Antagonist of the TLR4-MD2 Interaction. ChemBioChem, 10(4), 645-649.
    DOI Scopus34 WoS33 Europe PMC22
    2009 Rolan, P., Hutchinson, M., & Johnson, K. (2009). Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy, 10(17), 2897-2904.
    DOI Scopus88 WoS87 Europe PMC60
    2009 Hutchinson, M., Ramos, K., Loram, L., Wieseler-Frank, J., Sholar, P., Kearney, J., . . . Watkins, L. (2009). Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience, 164(4), 1821-1832.
    DOI Scopus52 WoS49 Europe PMC36
    2009 Loram, L., Harrison, J., Sloane, E., Hutchinson, M., Sholar, P., Taylor, F., . . . Watkins, L. (2009). Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: A novel therapy for neuropathic pain. Journal of Neuroscience, 29(44), 14015-14025.
    DOI Scopus81 WoS75 Europe PMC50
    2009 Liu, L., Hutchinson, M., White, J., Somogyi, A., & Coller, J. (2009). Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics (Print Edition), 19(11), 869-876.
    DOI Scopus34 WoS31 Europe PMC28
    2009 Watkins, L., Hutchinson, M., Rice, K., & Maier, S. (2009). The "Toll" of Opiod-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia. Trends in Pharmacological Sciences, 30(11), 581-591.
    DOI Scopus272 WoS261 Europe PMC202
    2009 Rodgers, K., Hutchinson, M., Northcutt, A., Maier, S., Watkins, L., & Barth, D. (2009). The cortical innate immune response increases local neuronal excitability leading to seizures. Brain, 132(9), 2478-2486.
    DOI Scopus106 WoS103 Europe PMC80
    2009 Bland, S., Hutchinson, M., Maier, S., Watkins, L., & Johnson, K. (2009). The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behavior and Immunity, 23(4), 492-497.
    DOI Scopus65 WoS57 Europe PMC51
    2009 Hutchinson, M., Lewis, S., Coats, B., Skyba, D., Crysdale, N., Berkelhammer, D., . . . Johnson, K. (2009). Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behavior and Immunity, 23(2), 240-250.
    DOI Scopus174 WoS170 Europe PMC124
    2008 Hutchinson, M., Coats, B., Lewis, S., Zhang, Y., Sprunger, D., Rezvani, N., . . . Watkins, L. (2008). Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behavior and Immunity, 22(8), 1178-1189.
    DOI Scopus226 WoS204 Europe PMC161
    2008 Hutchinson, M., Northcutt, A., Chao, L., Kearney, J., Zhang, Y., Berkelhammer, D., . . . Maier, S. (2008). Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behavior and Immunity, 22(8), 1248-1256.
    DOI Scopus137 WoS124 Europe PMC91
    2008 Hutchinson, M., Zhang, Y., Brown, K., Coats, B., Shridhar, M., Sholar, P., . . . Watkins, L. (2008). Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience, 28(1), 20-29.
    DOI Scopus277 WoS273 Europe PMC227
    2007 Watkins, L., Hutchinson, M., Milligan, E., & Maier, S. (2007). 'Listening' and 'talking' to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews, 56(1), 148-169.
    DOI Scopus145 WoS126 Europe PMC106
    2007 Der-Avakian, A., Bland, S., Rozeske, R., Tamblyn, J., Hutchinson, M., Watkins, L., & Maier, S. (2007). The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology, 191(4), 909-917.
    DOI Scopus32 WoS30 Europe PMC24
    2007 Watkins, L., Hutchinson, M., Ledeboer, A., Wieseler-Frank, J., Milligan, E., & Maier, S. (2007). Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids. Brain Behavior and Immunity, 21(2), 131-146.
    DOI Scopus263 WoS235 Europe PMC182
    2007 Hutchinson, M., Johnson, K., Rice, K., Maier, S., & Watkins, L. (2007). Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. The Scientific World Journal, 7(Suppl 2), 98-111.
    DOI Scopus269 WoS14 Europe PMC154
    2007 Ledeboer, A., Hutchinson, M., Watkins, L., & Johnson, K. (2007). Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion on Investigational Drugs, 16(7), 935-950.
    DOI Scopus115 WoS105 Europe PMC70
    2005 Hutchinson, M., & Somogyi, A. (2005). Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. International Immunopharmacology, 5(12), 1713-1722.
    DOI Scopus6 WoS4 Europe PMC4
    2005 Watkins, L., Hutchinson, M., Johnston, I., & Maier, S. (2005). Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences, 28(12), 661-669.
    DOI Scopus273 WoS249 Europe PMC179
    2004 Hutchinson, M., & Somogyi, A. (2004). (S)-(+)methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone. International Immunopharmacology, 4(12), 1525-1530.
    DOI Scopus12 WoS11 Europe PMC9
    2004 Hutchinson, M., La Vincente, S., & Somogyi, A. (2004). In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. Pain, 110(3), 751-755.
    DOI Scopus12 WoS11 Europe PMC10
    2004 Hutchinson, M., & Somogyi, A. (2004). Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. European Journal of Pharmacology, 494(2-3), 251-262.
    DOI Scopus9 WoS7 Europe PMC7
    2004 Hutchinson, M., Menelaou, A., Foster, D., Coller, J., & Somogyi, A. (2004). CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology, 57(3), 287-297.
    DOI Scopus116 WoS92 Europe PMC61
    2003 Menelaou, A., Hutchinson, M., Quinn, I., Christensen, A., & Somogyi, A. (2003). Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 785(1), 81-88.
    DOI Scopus22 WoS19 Europe PMC12
    2002 Hutchinson, M., & Somogyi, A. (2002). Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. European Journal of Pharmacology, 453(1), 27-32.
    DOI Scopus18 WoS18 Europe PMC12
    Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Tables 1-5.
    DOI
  • Book Chapters

    Year Citation
    2018 Holmes, J., Corrigan, F., & Hutchinson, M. R. (2018). Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression. In B. T. Baune (Ed.), Inflammation and Immunity in Depression Basic Science and Clinical Applications (pp. 223-240). United Kingdom: Academic Press.
    DOI
    2015 Thomas, J., Sanam, M., Johnson, J., & Nicotra, L. (2015). The relationship between opioids and immune signalling in the spinal cord. In Pain Control (Vol. 227, pp. 207-238). Springer Berlin Heidelberg.
    DOI Scopus13 Europe PMC7
    2014 Wang, X., Cochran, T. A., Hutchinson, M. R., Yin, H., & Watkins, L. R. (2014). Drug addiction. In M. E. Tremblay, & A. Sierra (Eds.), Microglia in health and disease (pp. 299-317). Online: Springer New York.
    DOI Scopus5
    2013 Sumracki, N., Nicotra, L., Kwok, Y., Liu, L., Steeg, K., Watkins, L., & Hutchinson, M. (2013). The future: new concepts and potential therapies. In C. Toth, & D. Moulin (Eds.), Neuropathic pain: causes, management and understanding (1 ed., pp. 341-356). United Kingdom: Cambridge University Press.
    DOI
    2013 Wu, Y., & Hutchinson, M. (2013). Therapeutic strategies to treat alcohol-related disorders targeting central immune signaling. In C. Cui, L. Grandison, & A. Noronha (Eds.), Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (1 ed., pp. 535-559). United States: Springer.
    DOI
    2013 The Wiley-Blackwell Handbook of Psychoneuroimmunology (2013). John Wiley & Sons Ltd.
    DOI
    2013 The Wiley-Blackwell Handbook of Psychoneuroimmunology (2013). John Wiley & Sons Ltd.
    DOI
    2012 Grace, P., Watkins, L., & Hutchinson, M. (2012). The Role of the Immune System in Chronic Pain Comorbidities. In M. Giamberardino, & T. Jensen (Eds.), Pain Comorbidities: Understanding and Treating the Complex Patient (1 ed., pp. 137-155). Seattle, WA: USA: IASP Press (International Association for the Study of Pain).
    2009 Gordon, A., Hutchinson, M., La Vincente, S., Mitchell, T., Morrish, G., Newcombe, D., . . . White, J. (2009). Pharmacology of opioid agonists and antagonists. In R. Mattick, R. Ali, & N. Lintzeris (Eds.), Pharmacotherapies for the Treatment of Opioid Dependence: Efficacy, Cost-Effectiveness and Implementation Guidelines (pp. 15-53). New York, USA: Informa.
    2007 Watkins, L. R., Wieseler-Frank, J., Hutchinson, M. R., Ledeboer, A., Spataro, L., Milligan, E. D., . . . Maier, S. F. (2007). Neuroimmune interactions and pain: The role of immune and glial cells. In Psychoneuroimmunology, Two-Volume Set (Vol. 1, pp. 393-414). Elsevier.
    DOI Scopus4
  • Conference Papers

    Year Citation
    2019 Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2019). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015 (pp. 1). online: OSA Publishing.
    2019 Schartner, E., Tsiminis, G., Henderson, M., Hutchinson, M., & Monro, T. (2019). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015. online: OSA Publishing.
    2019 Kostecki, R., Zhang, B., El Habti, A., Arman, A., Hutchinson, M., Tricker, P., . . . Ebendorff-Heidepriem, H. (2019). Reversible protein carbonylation in-vivo biosensor. In osapublishing.org Vol. Part F166-Sensors 2019 (pp. 1-2). online: OSA.
    DOI
    2019 Peng, L., Khalid, A., Warren-Smith, S. C., Arman, A., Schartner, E. P., Sylvia, G. M., . . . Li, J. (2019). Chemical sensing based on silk coated exposed-core fibers. In E. M. Goldys, & B. C. Gibson (Eds.), Biophotonics Australasia 2019 Vol. 11202 (pp. 112020G-1-112020G-2). Bellingham, Washington: SPIE.
    DOI
    2019 Kostecki, R., Zhang, B., El Habti, A., Arman, A., Hutchinson, M., Tricker, P., . . . Ebendorff-Heidepriem, H. (2019). Optical fiber based in-vivo oxidative stress biosensor. In Proceedings of SPIE - The International Society for Optical Engineering Vol. 11202 (pp. 1-3). online: SPIE.
    DOI
    2017 Hutchinson, M. R. (2017). The importance of knowing you are sick: Biophotonics for the 'Other' brain. In Optics InfoBase Conference Papers Vol. Part F41-CLEO_SI 2017 (pp. 1 page). San Jose, CA: IEEE.
    DOI WoS1
    2017 Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). An optical fibre based ex-vivo device for detection of cytokines. In IET Conference Publications Vol. 2017 (pp. 1-4). online: IET Digital Library.
    DOI
    2017 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In Proceedings of the 29th IEEE Photonics Conference (pp. 684-685). Waikoloa, HI: IEEE.
    DOI Scopus1 WoS1
    2016 Tsiminis, G., Schartner, E., Bekteshi, M., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow-core optical fibers made by glass billet extrusion as sensors for raman spectroscopy. In Optics InfoBase Conference Papers Vol. Part F3-ACOFT 2016 (pp. 1-2). online: OSA.
    DOI
    2016 Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). A portable optical fiber probe for in vivo brain temperature measurements. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI Scopus1 WoS1
    2016 Staikopoulos, V., Gosnell, M., Anwer, A., Mustafa, S., Hutchinson, M., & Goldys, E. (2016). Hyperspectral imaging of endogenous fluorescent metabolic molecules to identify pain states in central nervous system tissue. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 1-8). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI Scopus2 WoS2
    2016 Peddie, V., Heng, S., Mustafa, S., Thomas, J., Hutchinson, M., & Abell, A. (2016). Shapeshifting photoswitchable azobenzene compounds and their biological applications. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2016 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2016). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE: SPIE BioPhotonics Australasia Conference Vol. 10013 (pp. 100130M-1-100130M-4). Adelaide, Australia: SPIE.
    DOI
    2016 Tsiminis, G., Schartner, E., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow core optical fibres made by glass billet extrusion as sensors for Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2015 Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Optics InfoBase Conference Papers.
    2015 Dodds, K., Beckett, E., Staikopoulos, V., Evans, S., & Hutchinson, M. (2015). Novel mouse model of endometriosis permits identification of spinal glia and nociception characteristics involved in pelvic pain. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 267). Cairns, AUSTRALIA: WILEY-BLACKWELL.
    2015 Staikopoulos, V., Jin, D., Lu, Y., Gibson, B., Reineck, P., Goldys, E., . . . Hutchinson, M. (2015). Ultra-structural imaging in cleared mouse cns using nanoparticles. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 382). Cairns, AUSTRALIA: WILEY-BLACKWELL.
    2015 Jacobsen, J., Staikopoulos, V., & Hutchinson, M. (2015). Optimisation and utilisation of a novel whole-brain imaging technique (clarity) to analyse addiction-like behaviours. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 351). Cairns, AUSTRALIA: WILEY-BLACKWELL.
    2015 Schartner, E. P., Musolino, S., Salem, A., Hutchinson, M. R., & Monro, T. M. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015.
    2015 Schartner, E. P., Tsiminis, G., Henderson, M. R., Hutchinson, M. R., & Monro, T. M. (2015). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. In Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference, CLEO/Europe-EQEC 2015.
    2014 Maeda, H. (2014). THE EPR EFFECT AND BEYOND FOR CANCER SELECTIVE DRUG DELIVERY FOR TREATMENT AND IMAGING USING NANOMEDICINE. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 15). Toronto, CANADA: INFORMA HEALTHCARE.
    2014 Narayan, D., Casson, R. J., Ebneter, A., Chidlow, G., Grace, P. M., Hutchinson, M. R., & Wood, J. P. (2014). Immune priming and experimental glaucoma: The effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55 (pp. 7 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
    2007 Hutchinson, M. R., Coats, B. D., Zhang, Y., Lewis, S. S., Sprunger, D. B., Baker, E. M., . . . Watkins, L. R. (2007). Opioid-induced glial activation via a non-classical opioid receptor: clinical implications & the search for the target. In NEURON GLIA BIOLOGY Vol. 2 (pp. S16). CAMBRIDGE UNIV PRESS.
    WoS1
  • Conference Items

    Year Citation
    2020 Ho, R. M., Yin, C. P., Robertson, S. A., Hutchinson, M. L., & Keelan, J. A. (2020). Comparative Effects of TLR4 Inhibitors on Inflammatory Activation in Human Decidual Cells.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG.
    2016 Bajic, J. E., Whittaker, A. L., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. Poster session presented at the meeting of Multinational Association for Supportive Care in Cancer. Adelaide.
    2016 Whittaker, A. L., Bajic, J. E., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Chemotherapy Induces Intestinal Inflammation and Central Changes Which Are Modified by Analgesics via Neuro-Immune Mechanisms. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
    DOI
    2016 Bajic, J., Whittaker, A., Bobrovskaya, L., Hutchinson, M., & Howarth, G. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. Poster session presented at the meeting of Australian Society for Medical Research. Adelaide.
    2015 Bajic, J., Howarth, G., Eden, G., Lampton, L., Mashtoub, S., & Hutchinson, M. (2015). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Neurochemistry. Cairns, Australia: Wiley.
    DOI WoS1
    2014 Bajic, J. E., Howarth, G. S., Eden, G. L., Lampton, L. S., Mashtoub, S., & Hutchinson, M. R. (2014). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley.
    DOI
    2014 Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2014). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. Poster session presented at the meeting of Optics InfoBase Conference Papers.
    2014 Schartner, E., Tsiminis, G., Henderson, M., Hutchinson, M., & Monro, T. (2014). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. Poster session presented at the meeting of Optics InfoBase Conference Papers.
    2014 Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Currow, D., . . . Somogyi, A. (2014). Cyp2B6*6 Allele Alters Ketamine'S Pharmacokinetics In Chronic Pain Patients And Metabolism In Vitro. Poster session presented at the meeting of Drug Metabolism Reviews. Toronto, CANADA: Informa Healthcare.
    DOI Europe PMC1
    2014 Robertson, S. A., Chin, P. -Y., Dorian, C., & Hutchinson, M. (2014). Inhibition of the TLR4 Signalling Pathway Protects Mice from LPS-Induced Preterm Delivery. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
    2014 Robertson, S. A., Wahid, H. W., Dorian, C., Hutchinson, M., & Olson, D. M. (2014). Toll-Like Receptor 4 (TLR4) Signalling Is Implicated in Normal On-Time Labour in Mice. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
    2013 Rolan, P. E., Hutchinson, M. R., Buijs, M., Tuke, J., Kwok, Y. H., Gentgall, M., . . . Nillsen, N. (2013). First demonstration of the neuroimmune link in humans using IV Endotoxin and Intradermal Capsaicin in the face and arm. Poster session presented at the meeting of JOURNAL OF HEADACHE AND PAIN. SPRINGER-VERLAG ITALIA SRL.
    DOI
    2013 Kwiatek, R., Hutchinson, M., Cleland, L., Limaye, V., True, B., Lubhan, C., . . . Coller, J. (2013). GENETIC VARIABILITY IN CYTOKINE AND CYTOKINE RECEPTORS IN FIBROMYALGIA - A PILOT STUDY. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
    2013 Hutchinson, M. R. (2013). THE PROINFLAMMATORY HYPOTHESIS OF ADDICTION: CLINICAL AND PRECLINICAL EVIDENCE.. Poster session presented at the meeting of JOURNAL OF NEUROIMMUNE PHARMACOLOGY. SPRINGER.
    2013 Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Codeine, Increasing Pain & Medication Overuse Headache: The First Evidence of Codeine-Induced Hyperalgesia. Poster session presented at the meeting of CEPHALALGIA. Boston, MA: SAGE PUBLICATIONS LTD.
    2012 Zwicker, J. D., Zhang, Y., Hutchinson, M. R., Rice, K. C., Watkins, L. R., & Funk, G. D. (2012). Microglia attenuate the opioid-induced depression of preBotzinger Complex (preBotC) inspiratory rhythm in vitro via a TLR4-independent pathway. Poster session presented at the meeting of FASEB JOURNAL. San Diego, CA: FEDERATION AMER SOC EXP BIOL.
    WoS1
    2012 Narayan, D., Wood, J., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Casson, R. (2012). IMMUNE PRIMING AND EXPERIMENTAL GLAUCOMA: THE EFFECT OF PRIOR SYSTEMIC LIPOPOLYSACCHARIDE CHALLENGE ON TISSUE OUTCOMES AFTER OPTIC NERVE INJURY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL.
  • Internet Publications

    Year Citation
    Morphett, J., Whittaker, A., Reichelt, A., & Hutchinson, M. (n.d.). Perineuronal net structure as a non-cellular mechanism of affective state, a scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols.
    DOI
  • Datasets

    Year Citation
    Liddicoat, C., Sydnor, H., Cando-Dumancela, C., Dresken, R., Liu, J., Gellie, N., . . . Breed, M. (n.d.). Supporting Data - Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice.
    DOI
  • Figures

    Year Citation
    Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Figure 1.
    DOI

My research program has been funded by the following grant schemes

  • Meat and Livestock Australia
  • ARC Future Fellowship (FT180100565; Sole CI)
  • ARC discovery grant that includes an ARF (DP110100297; Sole CI)
  • NHMRC CJ Martin Postdoctoral Fellowship (Sole CI)
  • NHMRC project grant (APP1026178; CIB).
  • ARC Centre of Excellence for Nanoscale BioPhotonics ($38M, CE140100003)
  • NIH R01 grants as a PI (R01 DA034185; R01 DA025978; R01 DA23132; R01 DE017782)
  • USA Department of Defence CDMRP grant ($614K)
  • National Breast Cancer Foundation of Australia ($112K)
  • USA Fibromyalgia Association pilot grant ($55K)
  • ~$3M contract research on neuroimmune targeted therapies for pharmaceutical companies such as Phebra, Bionomics, Avigen, Covidien, Implicit Biosciences, NovImmune, Merck and J&J.

 

I regularly teach into continuing medical education courses for Medical Colleges, Faculties and Societies.

I also teach into several University of Adelaide undergraduate courses as an invited specialist lecturer

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2021 Principal Supervisor Exploring the neurobiological bases of affective states Doctor of Philosophy Doctorate Full Time Ms Jane Cerina Morphett
    2021 Principal Supervisor Regulation of the neuro-immune system Doctor of Philosophy Doctorate Full Time Mr Benjamin Daniel Barry
    2021 Principal Supervisor Effectiveness of Exercise to Improve Patient-Reported and Central Pain Modulation Outcomes in Chronic Neck Pain Doctor of Philosophy Doctorate Part Time Mr Kexun Kenneth Chen
    2021 Principal Supervisor Quantification of the lifetime experience of pain in livestock and its implications on productivity and animal husbandry practices, including applications to human health and wellbeing Doctor of Philosophy Doctorate Full Time Miss Charlotte Helen Johnston
    2021 Principal Supervisor The neuroimmune consequences of persistent pain in female mice: identification of biomarkers for objective pain measurement. Master of Philosophy (Medical Science) Master Full Time Miss Kariel Renee Siemens
    2020 Co-Supervisor Immunophenotyping of Spinal Cord Injured Patients – Advancing Diagnostics and Prognostics. Doctor of Philosophy Doctorate Part Time Mr James Edward Swift
    2019 Principal Supervisor Investigating the effects of human mesenchymal stem cells and conditioned media (secretome) for the treatment of pain and neuropathic pain. Doctor of Philosophy Doctorate Full Time Mr Chrysostomos Constantine Maoudis
    2018 Co-Supervisor Assessing Pain and Treatment Responsiveness in a Patient Cohort and Mouse Model of Inflammatory Arthritis Using Neurobiophotonics Doctor of Philosophy Doctorate Full Time Miss Florence Jade Lees
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2019 Principal Supervisor Peripheral-to-Central Neuroimmune Communication and the Sun: Implications for Addiction and Neurodegenerative Disease Pathology Master of Philosophy (Medical Science) Master Full Time Ms Krystal Lee Iacopetta
    2016 - 2020 Principal Supervisor The Role of Nitroxyl in the Development of Neuropathic Pain Doctor of Philosophy Doctorate Full Time Mrs Vicky Staikopoulos
    2015 - 2020 Principal Supervisor Investigation of a Functional Relationship Between Toll-Like Receptor 4 and Transient Receptor Potential Cation Channel Subfamily V Member 1 in Relation to a Novel Neuroimmune Pain Model Doctor of Philosophy Doctorate Full Time Samuel Greig Evans
    2015 - 2020 Principal Supervisor Advanced Preclinical Assessment of Hyper-Nociception Doctor of Philosophy Doctorate Full Time Mr Azim Arman
    2014 - 2018 Co-Supervisor Investigating the role of Toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury Doctor of Philosophy Doctorate Full Time Sam Man Lee
    2014 - 2019 Co-Supervisor An optical fibre point temperature sensor for investigation of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') induced hyperthermia in the rat brain Doctor of Philosophy Doctorate Full Time Mr Stefan Tyrone Musolino
    2014 - 2018 Principal Supervisor Exploring the Role of Spinal Glia and Toll-Like Receptor 4 in the Development of Endometriosis and Neuroimmune-Associated Pain Doctor of Philosophy Doctorate Full Time Kelsi Nicole Dodds
    2014 - 2019 Principal Supervisor From the Bottom Up: Chemotherapy-Induced Gut Toxicity, Glial Reactivity and Cognitive Impairment Doctor of Philosophy Doctorate Part Time Juliana Esma Bajic
    2014 - 2017 Principal Supervisor Exploring the Bidirectional Interface between Stress and Innate Immunity: A Focus on Glucocorticoid and TLR4-MyD88 Signalling Doctor of Philosophy Doctorate Full Time Dr Jiajun Liu
    2013 - 2017 Co-Supervisor Toll-Like Receptor 4 Signalling in Inflammation Pathways to Term and Preterm Delivery Doctor of Philosophy Doctorate Full Time Miss Hanan Hamimi Binti Wahid
    2013 - 2017 Principal Supervisor Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours Doctor of Philosophy Doctorate Full Time Jonathan Henry Jacobsen
    2011 - 2017 Principal Supervisor Neuroimmunopharmacology of Opioids Doctor of Philosophy Doctorate Full Time Dr Jacob Henry Lloyd Thomas
    2010 - 2015 Co-Supervisor Codeine, heightened pain sensitivity and medication overuse headache: A neuroimmune hypothesis and novel treatment strategy. Doctor of Philosophy Doctorate Full Time Miss Jacinta Lee Johnson
    2010 - 2015 Principal Supervisor Sex Differences in Allodynia: A complex Interaction Between 17beta-Oestradiol and the Innate Immune System Doctor of Philosophy Doctorate Full Time Miss Lauren Louise Nicotra
    2010 - 2014 Co-Supervisor Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Doctor of Philosophy Doctorate Full Time Mr Yibai Li
    2010 - 2015 Co-Supervisor The thermal grill as a tool to investigate analgesic clinical pharmacology Doctor of Philosophy Doctorate Full Time Mrs Nicole Martha Sumracki
    2009 - 2011 Co-Supervisor CNS Immune Signalling and Drug Addiction: Role of Interleukin-1 Beta Doctor of Philosophy Doctorate Full Time Mr Liang Liu
    2009 - 2014 Co-Supervisor Potential peripheral biomarkers for chronic pain Doctor of Philosophy Doctorate Full Time Miss Yuen Kwok
    2008 - 2011 Co-Supervisor The Neuroimmunopharmacology of Alcohol Doctor of Philosophy Doctorate Full Time Miss Yue Wu
    2007 - 2011 Co-Supervisor Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy Doctor of Philosophy Doctorate Full Time Mr Peter Grace
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  • Board Memberships

    Date Role Board name Institution name Country
    2013 - ongoing Board Member Science Technology Australia Australia
  • Memberships

    Date Role Membership Country
    2012 - ongoing Member Australian Pain Society Australia
    2007 - ongoing Member International Association for the Study of Pain United States
    2007 - ongoing Member Psychoneuroimmunology Research Society United States
    2002 - ongoing Member Society for Neuroscience United States
    1999 - ongoing Representative Australasian Society for Clinical and Experimental Pharmacology and Toxicology Australia
  • Editorial Boards

    Date Role Editorial Board Name Institution Country
    2015 - ongoing Associate Editor Brain, Behavior, and Immunity
  • Position: Director - Centre for Nanoscale BioPhotonics
  • Phone: 83130322
  • Email: mark.hutchinson@adelaide.edu.au
  • Fax: 8224 0685
  • Campus: North Terrace
  • Building: The Braggs, floor 3
  • Room: 3 10
  • Org Unit: Medical Sciences

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