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Professor Mark Hutchinson

Mark Hutchinson
Director - Centre for Nanoscale BioPhotonics
Adelaide Medical School
Faculty of Health and Medical Sciences

Mark Hutchinson is a Professor within the Adelaide Medical School and is the Director of the ARC Centre of Excellence for Nanoscale BioPhotonics.

Professor Hutchinson returned to the University of Adelaide in 2009 as an NHMRC CJ Martin Research Fellow, and established the Neuroimmunopharmacology research laboratory. From 2005 to 2009 Mark worked in the world leading laboratory of Prof Linda Watkins in the Center for Neuroscience at the University of Colorado, Boulder USA. Here he pioneered with Prof Watkins the research which has led to the discovery of a novel drug activity in innate immune receptors.

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Professor Mark Hutchinson

Mark Hutchinson is a Professor within the Adelaide Medical School and is the Director of the ARC Centre of Excellence for Nanoscale BioPhotonics.

Professor Hutchinson returned to the University of Adelaide in 2009 as an NHMRC CJ Martin Research Fellow, and established the Neuroimmunopharmacology research laboratory. From 2005 to 2009 Mark worked in the world leading laboratory of Prof Linda Watkins in the Center for Neuroscience at the University of Colorado, Boulder USA. Here he pioneered with Prof Watkins the research which has led to the discovery of a novel drug activity in innate immune receptors.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Mark’s research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments.

Mark has published over 100 papers in journals and refereed conference proceedings.

The CNBP is an ARC Centre of Excellence with $38M of funding committed for 7 years, headquartered at The University of Adelaide, with nodes at Macquarie University, Sydney and the RMIT, Melbourne. We are partnered with universities and companies in Europe, the US and China, as well as other  Australian institutions.  

The CNBP has a mission to "Discover new approaches to measure nano-scale  dynamic phenomena in living systems".  

The Scientific Aims of the CNBP are to:  

  1. Reach the limits of light-based measurement within complex and dynamic  biological environments;  
  2. Exploit physics and multiple scales -- nanoscale to macro -- using  photons to bridge from nanomaterial to devices;  
  3. Create smart, tailored interfaces between these nanoscale systems and  the biochemical environment;  
  4. Establish new forms of measurement assays that can operate within  living organisms; 
  5. Deploy these assays to address identified challenges in systems  including the embryo, brain and blood vessels; and  
  6. Seek molecular level insight into the mechanisms, processes and functionalities in these biological systems. 

Appointments

Date Position Institution name
2014 Director Australian Research Council Centre of Excellence for Nanoscale BioPhotonics
2014 Professor University of Adelaide
2013 - 2014 Associate Professor University of Adelaide
2011 - 2012 ARC Research Fellow University of Adelaide
2009 - 2010 NHMRC CJ Martin Research Fellow University of Adelaide
2005 - 2008 Postdoc Research Fellow University of Colorado Boulder

Awards and Achievements

Date Type Title Institution Name Country Amount
2015 Award The James McWha Award of Excellence University of Adelaide Australia
2014 Award Brain Behavior & Immunity Reviewer of the Year Elsevier Australia
2013 Nomination South Australian Leading Light Finalist Australian Society for Medical Research (ASMR) Australia
2013 Award Robert Ader New Investigator Psychoneuroimmunology Research Society
2012 Nomination Young Researcher Award Finalist Scopus
2012 Award Tess Cramond Lecturer Australian Pain Society Australia
2011 Award College on Problems of Drug Abuse Early Career Prize
2010 Award South Australian Tall Poppy Science Awardee Australia
2009 Award Denis Wade Johnson & Johnson New Investigators The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
2007 Award National Institute for Drug Addiction Young Investigator National Institute for Drug Addiction Australia
2006 Award Society on Neuroimmune Pharmacology Travel Society on Neuroimmune Pharmacology
2005 Award Oral Presentation Finalist Winner Front Range Neuroscience Group
2005 Fellowship American Australian Association Merck Company Foundation Fellow American Australian Association Merck Company Foundation
2005 Nomination Chapter travel award Front Range Neuroscience Group
2005 Award Chapter oral presentation winner Front Range Neuroscience Group
2005 Award Recipient of a British Council Travel British Council
2004 Award Australian FreshScience Winner Fresh Science Australia

Education

Date Institution name Country Title
2004 University of Adelaide Australia PhD in Medicine
1999 University of Adelaide Australia BSc (First class Honours) in Pharmacology
1998 University of Adelaide Australia BSc

Research Interests

Journals

Year Citation
2018 Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity, 67, 181-193.
DOI
2018 Jacobsen, J., Buisman-Pijlman, F., Mustafa, S., Rice, K., & Hutchinson, M. (2018). Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology, 128, 460-473.
DOI
2018 Hutchinson, M. (2018). The importance of knowing you are sick: nanoscale biophotonics for the 'other' brain. Microelectronic Engineering, 187-188, 101-104.
DOI Scopus1
2018 Marcu, L., Boppart, S., Hutchinson, M., Popp, J., & Wilson, B. (2018). Biophotonics: The big picture. Journal of Biomedical Optics, 23(2).
DOI Scopus1
2018 Hutchinson, M. (2018). Glial ties to persistent pain : Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain. Scientist, 32(1).
2018 Liu, J., Mustafa, S., Barratt, D., & Hutchinson, M. (2018). Corticosterone preexposure increases NF-κB translocation and sensitizes IL-1β responses in BV2 microglia-like cells. Frontiers in Immunology, 9(JAN), 1-12.
DOI
2018 Robertson, S., Wahid, H., Chin, P., Hutchinson, M., Moldenhauer, L., & Keelan, J. (2018). Toll-like receptor-4: A new target for preterm labour pharmacotherapies?. Current Pharmaceutical Design, 24(9), 960-973.
DOI Scopus1 WoS1
2018 Zhang, X., Cui, F., Chen, H., Zhang, T., Yang, K., Wang, Y., . . . Wang, X. (2018). Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling, 58(4), 816-825.
DOI
2018 Beckett, E., Staikopoulos, V., & Hutchinson, M. (2018). Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice. Scientific Reports, 8(1), 5923-1-5923-13.
DOI
2018 Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2018). Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive sciences (Thousand Oaks, Calif.), Online, 1-13.
DOI
2018 Zhang, K., Baratta, M., Liu, G., Frank, M., Leslie, N., Watkins, L., . . . Goldys, E. (2018). A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity, 71, 18-22.
DOI
2018 Hutchinson, M. (2018). ‘Convergence’ created psychoneuroimmunology, and is needed again to secure the future of the field. Brain, Behavior, and Immunity, 71, 1-2.
DOI
2018 Iacopetta, K., Collins-Praino, L., Buisman-Pijlman, F., Liu, J., Hutchinson, A., & Hutchinson, M. (2018). Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review. Nutritional Neuroscience.
DOI
2017 Johnston, I., Tan, M., Cao, J., Matsos, A., Forrest, D., Si, E., . . . Hutchinson, M. (2017). Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats. Behavioural Brain Research, 334, 109-118.
DOI Scopus1 WoS1
2017 Zohora, N., Kandjani, A., Orth, A., Brown, H., Hutchinson, M., & Gibson, B. (2017). Fluorescence brightness and photostability of individual copper (I) oxide nanocubes. Scientific Reports, 7(1), 16905-1-16905-8.
DOI
2017 Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). Sensitive cytokine assay based on optical fiber allowing localized and spatially resolved detection of interleukin-6. ACS Sensors, 2(2), 218-226.
DOI Scopus4 WoS2
2017 Dodds, K., Beckett, E., Evans, S., & Hutchinson, M. (2017). Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis. Biology of Reproduction, 97(6), 810-821.
DOI Europe PMC1
2017 Liu, G., Zhang, K., Ma, K., Care, A., Hutchinson, M., & Goldys, E. (2017). Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring. Nanoscale, 9(15), 4934-4943.
DOI Scopus6 WoS7
2017 Lewis, S., Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2017). Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity, 64, 59-64.
DOI Scopus1 WoS1 Europe PMC1
2017 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopy. Applied Spectroscopy Reviews, 52(5), 439-455.
DOI Scopus1 WoS1
2016 Jacobsen, J., Parker, L., Everest-Dass, A., Schartner, E., Tsiminis, G., Staikopoulos, V., . . . Mustafa, S. (2016). Novel imaging tools for investigating the role of immune signalling in the brain. Brain, Behavior, and Immunity, 58, 40-47.
DOI Scopus4 WoS3 Europe PMC1
2016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Coller, J., White, I., . . . Bowen, J. (2016). Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics, 15(6), 1376-1386.
DOI Scopus12 WoS12 Europe PMC9
2016 Lee, S., Hutchinson, M., & Saint, D. (2016). The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology and Physiology, 43(9), 864-871.
DOI Scopus4 WoS4 Europe PMC5
2016 Chalmers, K., Madden, V., Hutchinson, M., & Moseley, G. (2016). Local and systemic inflammation in localized, provoked vestibulodynia. Obstetrics and Gynecology, 128(2), 337-347.
DOI Scopus2 WoS1 Europe PMC1
2016 Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). Portable optical fiber probe for in vivo brain temperature measurements. Biomedical Optics Express, 7(8), 3069-3078.
DOI Scopus9 WoS8 Europe PMC2
2016 Ellis, A., Grace, P., Wieseler, J., Favret, J., Springer, K., Skarda, B., . . . Watkins, L. (2016). Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity, 58, 348-356.
DOI Scopus14 WoS11 Europe PMC10
2016 Dodds, K., Beckett, E., Evans, S., Grace, P., Watkins, L., & Hutchinson, M. (2016). Glial contributions to visceral pain : implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry, 6(9), e888-1-e888-13.
DOI Scopus8 WoS7 Europe PMC5
2016 Somogyi, A., Sia, A., Tan, E., Coller, J., Hutchinson, M., & Barratt, D. (2016). Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain, 157(11), 2458-2466.
DOI
2016 Chin, P., Dorian, C., Hutchinson, M., Olson, D., Rice, K., Moldenhauer, L., & Robertson, S. (2016). Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports, 6(1), 36112-1-36112-13.
DOI Scopus4 WoS3 Europe PMC2
2016 Grace, P., Gaudet, A., Staikopoulos, V., Maier, S., Hutchinson, M., Salvemini, D., & Watkins, L. (2016). Nitroxidative signaling mechanisms in pathological pain. Trends in Neurosciences, 39(12), 862-879.
DOI Scopus8 WoS9 Europe PMC6
2016 Gibson, R., Coller, J., Wardill, H., Hutchinson, M., Smid, S., & Bowen, J. (2016). Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer, 24(5), 2251-2258.
DOI Scopus6 WoS7 Europe PMC3
2016 Wang, X., Zhang, Y., Peng, Y., Hutchinson, M., Rice, K., Yin, H., & Watkins, L. (2016). Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. British Journal of Pharmacology, 173(5), 856-869.
DOI Scopus24 WoS23 Europe PMC18
2016 Jacobsen, J., Hutchinson, M., & Mustafa, S. (2016). Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology, 26, 131-137.
DOI Scopus7 WoS6 Europe PMC4
2016 Liu, G., Qi, M., Hutchinson, M., Yang, G., & Goldys, E. (2016). Recent advances in cytokine detection by immunosensing. Biosensors and Bioelectronics, 79, 810-821.
DOI Scopus25 WoS25 Europe PMC9
2015 Johnson, J., Kwok, Y., Sumracki, N., Swift, J., Hutchinson, M., Johnson, K., . . . Rolan, P. (2015). Glial attenuation with ibudilast in the treatment of medication overuse headache: a double-blind, randomized, placebo-controlled pilot trial of efficacy and safety. Headache, 55(9), 1192-1208.
DOI Scopus7 WoS7 Europe PMC4
2015 Lee, S., Hutchinson, M., Staikopoulos, V., & Saint, D. (2015). Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. International Journal of Cardiology, 190, 353-359.
DOI Scopus5 WoS5 Europe PMC4
2015 Ingman, W., Glynn, D., & Hutchinson, M. (2015). Mouse models of mastitis - how physiological are they?. International Breastfeeding Journal, 10(1), 12-1-12-5.
DOI Scopus5 WoS5 Europe PMC5
2015 Wahid, H., Dorian, C., Chin, P., Hutchinson, M., Rice, K., Olson, D., . . . Robertson, S. (2015). Toll-like receptor 4 Is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology, 156(10), 3828-3841.
DOI Scopus10 WoS6 Europe PMC4
2015 Bachtell, R., Hutchinson, M., Wang, X., Rice, K., Maier, S., & Watkins, L. (2015). Targeting the toll of drug abuse: the translational potential of toll-like receptor 4. CNS and Neurological Disorders - Drug Targets, 14(6), 692-699.
DOI Scopus20 WoS18 Europe PMC14
2015 Corrigan, F., Wu, Y., Tuke, J., Coller, J., Rice, K., Diener, K., . . . Hutchinson, M. (2015). Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity, 45, 245-252.
DOI Scopus10 WoS10 Europe PMC8
2015 Northcutt, A., Hutchinson, M., Wang, X., Baratta, M., Hiranita, T., Cochran, T., . . . Watkins, L. (2015). DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry, 20(12), 1525-1537.
DOI Scopus37 WoS32 Europe PMC23
2015 Li, Y., Jackson, K., Slon, B., Hardy, J., Franco, M., William, L., . . . Somogyi, A. (2015). CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects. British Journal of Clinical Pharmacology, 80(2), 276-284.
DOI Scopus11 WoS10 Europe PMC9
2015 Lewis, S., Hutchinson, M., Frick, M., Zhang, Y., Maier, S., Sammakia, T., . . . Watkins, L. (2015). Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity, 44, 128-136.
DOI Scopus7 WoS7 Europe PMC3
2014 Liu, J., Buisman-Pijlman, F., & Hutchinson, M. (2014). Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder. Frontiers in Neuroscience, 8(SEP), 309-1-309-15.
DOI Scopus33 WoS28 Europe PMC23
2014 Jacobsen, J., Watkins, L., & Hutchinson, M. (2014). Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology, 118, 129-163.
DOI Scopus22 WoS18 Europe PMC14
2014 Hutchinson, M. (2014). Want more pain? Just add a dash of endotoxin to enhance your clinical pain model. Brain, Behavior, and Immunity, 41(1), 44-45.
DOI Scopus5 WoS5 Europe PMC4
2014 Watkins, L., & Hutchinson, M. (2014). A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: Comment on Smith and Dragunow. Trends in Neurosciences, 37(4), 189-190.
DOI Scopus6 WoS5 Europe PMC3
2014 Johnson, J., Rolan, P., Johnson, M., Bobrovskaya, L., Williams, D., Johnson, K., . . . Hutchinson, M. (2014). Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry, 4(11), e482-1-e482-9.
DOI Scopus10 WoS10 Europe PMC7
2014 Grace, P., Ramos, K., Rodgers, K., Wang, X., Hutchinson, M., Lewis, M., . . . Watkins, L. (2014). Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience, 280, 299-317.
DOI Scopus24 WoS23 Europe PMC19
2014 Nicotra, L., Tuke, S., Grace, P., Rolan, P., & Hutchinson, M. (2014). Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?. Frontiers in Behavioral Neuroscience, 8(February), 1-16.
DOI Scopus12 WoS11 Europe PMC8
2014 Sumracki, N., Buisman-Pijlman, F., Hutchinson, M., Gentgall, M., & Rolan, P. (2014). Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine, 15(4), 647-660.
DOI Scopus6 WoS6 Europe PMC5
2014 Narayan, D., Casson, R., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Wood, J. (2014). Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. Clinical and Experimental Ophthalmology, 42(6), 539-554.
DOI Scopus2
2014 Glynn, D., Hutchinson, M., & Ingman, W. (2014). Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction, 90(5), 1-11.
DOI Scopus14 WoS14 Europe PMC12
2014 Grace, P., Hutchinson, M., Maier, S., & Watkins, L. (2014). Pathological pain and the neuroimmune interface. Nature Reviews Immunology, 14(4), 217-231.
DOI Scopus217 WoS208 Europe PMC155
2014 Watkins, L., Wang, X., Mustafa, S., & Hutchinson, M. (2014). In vivo veritas: (+)-Naltrexone's actions define translational importance. A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences, 35(9), 432-433.
DOI Scopus6 WoS6 Europe PMC6
2014 Ingman, W., Glynn, D., & Hutchinson, M. (2014). Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia, 19(2), 161-167.
DOI Scopus11 WoS11 Europe PMC9
2014 Zwicker, J., Zhang, Y., Ren, J., Hutchinson, M., Rice, K., Watkins, L., . . . Funk, G. (2014). Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology, 117(8), 857-868.
DOI Scopus6 WoS6 Europe PMC4
2014 Mulholland, C., Somogyi, A., Barratt, D., Coller, J., Hutchinson, M., Jacobson, G., . . . Sleigh, J. (2014). Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia. Journal of Molecular Neuroscience, 52(4), 497-506.
DOI Scopus6 WoS4 Europe PMC4
2014 Hutchinson, M., & Watkins, L. (2014). Why is neuroimmunopharmacology crucial for the future of addiction research?. Neuropharmacology, 76(Part B), 218-227.
DOI Scopus38 WoS36 Europe PMC30
2013 Thomas, J., & Hutchinson, M. (2013). Erratum: Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (Expert Review of Neurotherapeutics (2012) 12:11 (1311-1324)). Expert Review of Neurotherapeutics, 13(3), 339-340.
DOI
2013 Thomas, J., & Hutchinson, M. R. (2013). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (vol 12, pg 1311, 2012). EXPERT REVIEW OF NEUROTHERAPEUTICS, 13(3), 339-340.
2013 Kwok, Y., Tuke, S., Nicotra, L., Grace, P., Rolan, P., & Hutchinson, M. (2013). TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. PLoS One, 8(10), 1-16.
DOI Scopus8 WoS7 Europe PMC7
2013 Della Vedova, C., Cathcart, S., Dohnalek, A., Lee, V., Hutchinson, M., Immink, M., & Hayball, J. (2013). Peripheral interleukin-1β levels are elevated in chronic tension-type headache patients. Pain Research & Management : The Journal of the Canadian Pain Society = journal de la société canadienne pour le traitement de la douleur, 18(6), 301-306.
DOI Scopus11 WoS7 Europe PMC5
2013 Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Stanley, N., . . . Somogyi, A. (2013). The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition, 41(6), 1264-1272.
DOI Scopus15 WoS13 Europe PMC11
2013 Hutchinson, M., Bujis, M., Tuke, S., Kwok, Y., Gentgall, M., Williams, D., & Rolan, P. (2013). Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behavior and Immunity, 30, 3-11.
DOI Scopus29 WoS26 Europe PMC19
2013 Theberge, F., Li, X., Kambhampati, S., Pickens, C., St Laurent, R., Bossert, J., . . . Shaham, Y. (2013). Effect of chronic delivery of the toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry, 73(8), 729-737.
DOI Scopus44 WoS43 Europe PMC36
2013 Lewis, S., Hutchinson, M., Zhang, Y., Hund, D., Maier, S., Rice, K., & Watkins, L. (2013). Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behavior and Immunity, 30, 24-32.
DOI Scopus24 WoS21 Europe PMC19
2013 Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia, 33(1), 52-64.
DOI Scopus23 WoS18 Europe PMC17
2012 Jalleh, R., Koh, K., Choi, B., Liu, E., Maddison, J., & Hutchinson, M. (2012). Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Medical Hypotheses, 79(6), 735-739.
DOI Scopus11 WoS7 Europe PMC4
2012 Kwok, Y., Hutchinson, M., Gentgall, M., & Rolan, P. (2012). Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. PLoS One, 7(8), 1-8.
DOI Scopus23 WoS23 Europe PMC17
2012 Hutchinson, M., Northcutt, A., Hiranita, T., Wang, X., Lewis, S., Thomas, J., . . . Watkins, L. (2012). Opioid activation of toll-like receptor 4 contributes to drug reinforcement. Journal of Neuroscience, 32(33), 11187-11200.
DOI Scopus109 WoS104 Europe PMC80
2012 Grace, P., Hurley, D., Barratt, D., Tsykin, A., Watkins, L., Rolan, P., & Hutchinson, M. (2012). Harnessing pain heterogeneity and RNA transcriptome to idenitfy blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic construction injury model. Journal of Neurochemistry, 122(5), 976-994.
DOI Scopus11 WoS11 Europe PMC10
2012 Watkins, L., Hutchinson, M., & Johnson, K. (2012). Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology, 234(2), 351-353.
DOI Scopus15 WoS15 Europe PMC15
2012 Corrigan, F., & Hutchinson, M. (2012). Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling?. Expert Review of Clinical Immunology, 8(3), 201-203.
DOI Scopus2 WoS1
2012 Sumracki, N., Hutchinson, M., Gentgall, M., Briggs, N., Williams, D., & Rolan, P. (2012). The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One, 7(6), 1-8.
DOI Scopus12 WoS9 Europe PMC8
2012 Lewis, S., Loram, L., Hutchinson, M., Li, C., Zhang, Y., Maier, S., . . . Watkins, L. (2012). (+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain, 13(5), 498-506.
DOI Scopus45 WoS40 Europe PMC33
2012 Wang, X., Loram, L., Ramos, K., de Jesus, A., Thomas, J., Cheng, K., . . . Yin, H. (2012). Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6325-6330.
DOI Scopus161 WoS158 Europe PMC121
2012 Coller, J., & Hutchinson, M. (2012). Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & Therapeutics, 134(2), 219-245.
DOI Scopus71 WoS62 Europe PMC46
2012 Nicotra, L., Loram, L., Watkins, L., & Hutchinson, M. (2012). Toll-like receptors in chronic pain. Experimental Neurology, 234(2), 316-329.
DOI Scopus105 WoS93 Europe PMC75
2012 Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Coller, J., Rice, K., . . . Hutchinson, M. (2012). Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology, 165(5), 1319-1329.
DOI Scopus53 WoS44 Europe PMC36
2012 Thomas, J., & Hutchinson, M. (2012). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids. Expert Review of Neurotherapeutics, 12(11), 1311-1324.
DOI Scopus6 WoS6 Europe PMC4
2011 Liu, L., Ghosh, N., Slivka, P., Fiorini, Z., Hutchinson, M., Watkins, L., & Yin, H. (2011). An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. ChemBioChem, 12(12), 1827-1831.
DOI Scopus10 WoS8 Europe PMC6
2011 Schwarz, J., Hutchinson, M., & Bilbo, S. (2011). Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. Journal of Neuroscience, 31(49), 17835-17847.
DOI Scopus82 WoS77 Europe PMC64
2011 Anderson, P., Hutchinson, M., Irvine, R., & Salem, A. (2011). Attenuating glial activation with minocycline reduces the hyperthermic response to 3, 4-methylenedioxymethamphetamine (MDMA) in the rat. The Open Addiction Journal, 4(Sp Iss), 4-5.
DOI
2011 Salem, A., Gordon, J., Hutchinson, M., & Irvine, R. (2011). 3,4-Methylenedioxymethamphetamine (MDMA) induced hyperthermia - the role of pro-inflammatory cytokines. The Open Addiction Journal, 4(Sp Iss), 48-49.
DOI
2011 Grace, P., Rolan, P., & Hutchinson, M. (2011). Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behavior and Immunity, 25(7), 1322-1332.
DOI Scopus57 WoS54 Europe PMC46
2011 Liu, L., Coller, J., Watkins, L., Somogyi, A., & Hutchinson, M. (2011). Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains. Brain Behavior and Immunity, 25(6), 1223-1232.
DOI Scopus30 WoS28 Europe PMC24
2011 Hutchinson, M., Shavit, Y., Grace, P., Rice, K., Maier, S., & Watkins, L. (2011). Exploring the neuroimmunopharmacology of opioids: An integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews, 63(3), 772-810.
DOI Scopus177 WoS162 Europe PMC131
2011 Wu, Y., Lousberg, E., Moldenhauer, L., Hayball, J., Robertson, S., Coller, J., . . . Hutchinson, M. (2011). Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain Behavior and Immunity, 25(Suppl 1), 155-164.
DOI Scopus42 WoS33 Europe PMC26
2011 Grace, P., Hutchinson, M., Bishop, A., Somogyi, A., Mayrhofer, G., & Rolan, P. (2011). Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain Behavior and Immunity, 25(3), 503-513.
DOI Scopus11 WoS10 Europe PMC10
2010 Grace, P., Hutchinson, M., Manavis, J., Somogyi, A., & Rolan, P. (2010). A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods, 193(1), 47-53.
DOI Scopus18 WoS19 Europe PMC17
2010 Joce, C., Stahl, J., Shridhar, M., Hutchinson, M., Watkins, L., Fedichev, P., & Yin, H. (2010). Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters, 20(18), 5411-5413.
DOI Scopus28 WoS26 Europe PMC20
2010 Stanley, N., Hutchinson, M., Kvist, T., Nielsen, B., Mathiesen, J., Brauner-Osborne, H., . . . Taylor, D. (2010). A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry, 18(16), 6089-6098.
DOI Scopus3 WoS1
2010 Buchanan, M., Hutchinson, M., Watkins, L., & Yin, H. (2010). Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry, 114(1), 13-27.
DOI Scopus154 WoS152 Europe PMC113
2010 Hutchinson, M., Zhang, Y., Shridhar, M., Evans, J., Buchanan, M., Zhao, T., . . . Watkins, L. (2010). Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behavior and Immunity, 24(1), 83-95.
DOI Scopus237 WoS220 Europe PMC177
2010 Lewis, S., Hutchinson, M., Rezvani, N., Loram, L., Zhang, Y., Maier, S., . . . Watkins, L. (2010). Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience, 165(2), 569-583.
DOI Scopus81 WoS74 Europe PMC65
2010 Hutchinson, M., Loram, L., Zhang, Y., Shridhar, M., Rezvani, N., Berkelhammer, D., . . . Watkins, L. (2010). Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience, 168(2), 551-563.
DOI Scopus55 WoS50 Europe PMC36
2010 Hutchinson, M., Lewis, S., Coats, B., Rezvani, N., Zhang, Y., Wieseler, J., . . . Watkins, L. (2010). Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience, 167(3), 880-893.
DOI Scopus66 WoS58 Europe PMC53
2009 Slivka, P., Shridhar, M., Lee, G., Sammond, D., Hutchinson, M., Martinko, A., . . . Yin, H. (2009). A Peptide Antagonist of the TLR4-MD2 Interaction. ChemBioChem, 10(4), 645-649.
DOI Scopus29 WoS27 Europe PMC21
2009 Rolan, P., Hutchinson, M., & Johnson, K. (2009). Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy, 10(17), 2897-2904.
DOI Scopus63 WoS63 Europe PMC46
2009 Hutchinson, M., Ramos, K., Loram, L., Wieseler-Frank, J., Sholar, P., Kearney, J., . . . Watkins, L. (2009). Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience, 164(4), 1821-1832.
DOI Scopus44 WoS38 Europe PMC25
2009 Loram, L., Harrison, J., Sloane, E., Hutchinson, M., Sholar, P., Taylor, F., . . . Watkins, L. (2009). Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: A novel therapy for neuropathic pain. Journal of Neuroscience, 29(44), 14015-14025.
DOI Scopus68 WoS62 Europe PMC40
2009 Liu, L., Hutchinson, M., White, J., Somogyi, A., & Coller, J. (2009). Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics (Print Edition), 19(11), 869-876.
DOI Scopus21 WoS19 Europe PMC13
2009 Watkins, L., Hutchinson, M., Rice, K., & Maier, S. (2009). The "Toll" of Opiod-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia. Trends in Pharmacological Sciences, 30(11), 581-591.
DOI Scopus199 WoS180 Europe PMC142
2009 Rodgers, K., Hutchinson, M., Northcutt, A., Maier, S., Watkins, L., & Barth, D. (2009). The cortical innate immune response increases local neuronal excitability leading to seizures. Brain, 132(9), 2478-2486.
DOI Scopus93 WoS87 Europe PMC72
2009 Bland, S., Hutchinson, M., Maier, S., Watkins, L., & Johnson, K. (2009). The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain Behavior and Immunity, 23(4), 492-497.
DOI Scopus46 WoS40 Europe PMC31
2009 Hutchinson, M., Lewis, S., Coats, B., Skyba, D., Crysdale, N., Berkelhammer, D., . . . Johnson, K. (2009). Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behavior and Immunity, 23(2), 240-250.
DOI Scopus127 WoS122 Europe PMC92
2008 Hutchinson, M., Coats, B., Lewis, S., Zhang, Y., Sprunger, D., Rezvani, N., . . . Watkins, L. (2008). Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behavior and Immunity, 22(8), 1178-1189.
DOI Scopus173 WoS149 Europe PMC119
2008 Hutchinson, M., Northcutt, A., Chao, L., Kearney, J., Zhang, Y., Berkelhammer, D., . . . Maier, S. (2008). Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behavior and Immunity, 22(8), 1248-1256.
DOI Scopus95 WoS80 Europe PMC58
2008 Hutchinson, M., Zhang, Y., Brown, K., Coats, B., Shridhar, M., Sholar, P., . . . Watkins, L. (2008). Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience, 28(1), 20-29.
DOI Scopus208 WoS201 Europe PMC171
2007 Watkins, L., Hutchinson, M., Milligan, E., & Maier, S. (2007). 'Listening' and 'talking' to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews, 56(1), 148-169.
DOI Scopus126 WoS106 Europe PMC92
2007 Der-Avakian, A., Bland, S., Rozeske, R., Tamblyn, J., Hutchinson, M., Watkins, L., & Maier, S. (2007). The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology, 191(4), 909-917.
DOI Scopus27 WoS24 Europe PMC20
2007 Watkins, L., Hutchinson, M., Ledeboer, A., Wieseler-Frank, J., Milligan, E., & Maier, S. (2007). Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids. Brain Behavior and Immunity, 21(2), 131-146.
DOI Scopus225 WoS198 Europe PMC161
2007 Hutchinson, M., Johnson, K., Rice, K., Maier, S., & Watkins, L. (2007). Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. The Scientific World Journal, 7(Suppl 2), 98-111.
DOI Scopus213 WoS8 Europe PMC110
2007 Ledeboer, A., Hutchinson, M., Watkins, L., & Johnson, K. (2007). Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion on Investigational Drugs, 16(7), 935-950.
DOI Scopus98 WoS90 Europe PMC61
2005 Hutchinson, M., & Somogyi, A. (2005). Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. International Immunopharmacology, 5(12), 1713-1722.
DOI Scopus6 WoS4 Europe PMC4
2005 Watkins, L., Hutchinson, M., Johnston, I., & Maier, S. (2005). Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences, 28(12), 661-669.
DOI Scopus228 WoS206 Europe PMC150
2004 Hutchinson, M., & Somogyi, A. (2004). (S)-(+)methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone. International Immunopharmacology, 4(12), 1525-1530.
DOI Scopus10 WoS9 Europe PMC8
2004 Hutchinson, M., La Vincente, S., & Somogyi, A. (2004). In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. Pain, 110(3), 751-755.
DOI Scopus11 WoS9 Europe PMC9
2004 Hutchinson, M., & Somogyi, A. (2004). Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. European Journal of Pharmacology, 494(2-3), 251-262.
DOI Scopus8 WoS6 Europe PMC6
2004 Hutchinson, M., Menelaou, A., Foster, D., Coller, J., & Somogyi, A. (2004). CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology, 57(3), 287-297.
DOI Scopus97 WoS78 Europe PMC47
2003 Menelaou, A., Hutchinson, M., Quinn, I., Christensen, A., & Somogyi, A. (2003). Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 785(1), 81-88.
DOI Scopus20 WoS17 Europe PMC9
2002 Hutchinson, M., & Somogyi, A. (2002). Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. European Journal of Pharmacology, 453(1), 27-32.
DOI Scopus17 WoS16 Europe PMC12

Book Chapters

Year Citation
2015 Thomas, J., Sanam, M., Johnson, J., & Nicotra, L. (2015). The relationship between opioids and immune signalling in the spinal cord. In Unknown Book (Vol. 227, pp. 207-238).
DOI Scopus7 Europe PMC4
2014 Wang, X., Cochran, T. A., Hutchinson, M. R., Yin, H., & Watkins, L. R. (2014). Drug addiction. In M. E. Tremblay, & A. Sierra (Eds.), Microglia in health and disease (pp. 299-317). Springer New York.
DOI Scopus1
2013 Sumracki, N., Nicotra, L., Kwok, Y., Liu, L., Steeg, K., Watkins, L., & Hutchinson, M. (2013). The future: new concepts and potential therapies. In C. Toth, & D. Moulin (Eds.), Neuropathic pain: causes, management and understanding (1 ed., pp. 341-356). United Kingdom: Cambridge University Press.
DOI
2013 Wu, Y., & Hutchinson, M. (2013). Therapeutic strategies to treat alcohol-related disorders targeting central immune signaling. In C. Cui, L. Grandison, & A. Noronha (Eds.), Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (1 ed., pp. 535-559). United States: Springer.
DOI
2013 Grace, P. M., Watkins, L. R., & Hutchinson, M. R. (2013). The Wiley-Blackwell Handbook of Psychoneuroimmunology. In A. W. Kusnecov, & H. Anisman (Eds.), The Wiley-Blackwell Handbook of Psychoneuroimmunology (pp. 176 (552 pages)). John Wiley & Sons.
2012 Grace, P., Watkins, L., & Hutchinson, M. (2012). The role of the immune system in chronic pain comorbidities. In M. Giamberardino, & T. Jensen (Eds.), Pain Comorbidities: Understanding and Treating the Complex Patient (1 ed., pp. 137-155). Seattle, WA: USA: IASP Press (International Association for the Study of Pain).
2009 Gordon, A., Hutchinson, M., La Vincente, S., Mitchell, T., Morrish, G., Newcombe, D., . . . White, J. (2009). Pharmacology of opioid agonists and antagonists. In R. P. Mattick, R. Ali, & N. Lintzeris (Eds.), Pharmacotherapies for the Treatment of Opioid Dependence: Efficacy, Cost-Effectiveness and Implementation Guidelines (pp. 15-53). New York, USA: Informa.
2007 Watkins, L., Wieseler-Frank, J., Hutchinson, M., Ledeboer, A., Spataro, L., Milligan, E., . . . Maier, S. (2007). Neuroimmune interactions and pain: The role of immune and glial cells. In Psychoneuroimmunology, Two-Volume Set (Vol. 1, pp. 393-414).
DOI Scopus3

Conference Papers

Year Citation
2017 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2017). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In 2016 IEEE Photonics Conference, IPC 2016 (pp. 684-685). Waikoloa, HI: IEEE.
DOI
2017 Hutchinson, M. (2017). The importance of knowing you are sick: Biophotonics for the 'Other' brain. In Optics InfoBase Conference Papers Vol. Part F41-CLEO_SI 2017.
DOI
2017 Liu, G., Zhang, K., Nadort, A., Hutchinson, M., & Goldys, E. (2017). An optical fibre based ex-vivo device for detection of cytokines. In IET Conference Publications Vol. 2017.
2016 Tsiminis, G., Schartner, E., Bekteshi, M., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow-core optical fibers made by glass billet extrusion as sensors for raman spectroscopy. In Optics InfoBase Conference Papers Vol. Part F3-ACOFT 2016 (pp. 1-2). Sydney Australia.
DOI
2016 Musolino, S., Schartner, E., Tsiminis, G., Salem, A., Monro, T., & Hutchinson, M. (2016). A portable optical fiber probe for in vivo brain temperature measurements. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2016 Staikopoulos, V., Gosnell, M., Anwer, A., Mustafa, S., Hutchinson, M., & Goldys, E. (2016). Hyperspectral imaging of endogenous fluorescent metabolic molecules to identify pain states in central nervous system tissue. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 1-8). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2016 Peddie, V., Heng, S., Mustafa, S., Thomas, J., Hutchinson, M., & Abell, A. (2016). Shapeshifting photoswitchable azobenzene compounds and their biological applications. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2016 Tsiminis, G., Schartner, E., Brooks, J., & Hutchinson, M. (2016). Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2016 Tsiminis, G., Schartner, E., Hutchinson, M., & Ebendorff-Heidepriem, H. (2016). Hollow core optical fibres made by glass billet extrusion as sensors for Raman spectroscopy. In M. Hutchinson, & E. Goldys (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 10013 (pp. 4 pages). Adelaide, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2015 Dodds, K., Beckett, E., Staikopoulos, V., Evans, S., & Hutchinson, M. (2015). Novel mouse model of endometriosis permits identification of spinal glia and nociception characteristics involved in pelvic pain. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 267). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015 Staikopoulos, V., Jin, D., Lu, Y., Gibson, B., Reineck, P., Goldys, E., . . . Hutchinson, M. (2015). Ultra-structural imaging in cleared mouse cns using nanoparticles. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 382). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015 Jacobsen, J., Staikopoulos, V., & Hutchinson, M. (2015). Optimisation and utilisation of a novel whole-brain imaging technique (clarity) to analyse addiction-like behaviours. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 351). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2015 Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2015). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. In Optics InfoBase Conference Papers.
2007 Hutchinson, M., Coats, B., Zhang, Y., Lewis, S., Sprunger, D., Baker, E., . . . Watkins, L. (2007). Opioid-induced glial activation via a non-classical opioid receptor: clinical implications & the search for the target. In NEURON GLIA BIOLOGY Vol. 2 (pp. S16). CAMBRIDGE UNIV PRESS.
WoS1

Conference Items

Year Citation
2016 Bajic, J. E., Whittaker, A. L., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. Poster session presented at the meeting of Multinational Association for Supportive Care in Cancer. Adelaide.
2016 Whittaker, A. L., Bajic, J. E., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). Chemotherapy Induces Intestinal Inflammation and Central Changes Which Are Modified by Analgesics via Neuro-Immune Mechanisms. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
DOI
2016 Bajic, J., Whittaker, A., Bobrovskaya, L., Hutchinson, M., & Howarth, G. (2016). Intestinal mucositis induced by 5-Fluorouracil results in glial changes modified by analgesics via neuro-immune mechanisms. Poster session presented at the meeting of Australian Society for Medical Research. Adelaide.
2015 Bajic, J., Howarth, G., Eden, G., Lampton, L., Mashtoub, S., & Hutchinson, M. (2015). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Neurochemistry. Cairns, Australia: Wiley.
DOI WoS1
2014 Schartner, E., Musolino, S., Salem, A., Hutchinson, M., & Monro, T. (2014). Rare-earth thermometry using functionalised optical fibre tips for in vivo measurements of brain temperature. Poster session presented at the meeting of Optics InfoBase Conference Papers.
2014 Schartner, E., Tsiminis, G., Henderson, M., Hutchinson, M., & Monro, T. (2014). A comparison between multimode tip and suspended core fluorescence optical fibre sensors. Poster session presented at the meeting of Optics InfoBase Conference Papers.
2014 Robertson, S. A., Chin, P. -Y., Dorian, C., & Hutchinson, M. (2014). Inhibition of the TLR4 Signalling Pathway Protects Mice from LPS-Induced Preterm Delivery. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
2014 Robertson, S. A., Wahid, H. W., Dorian, C., Hutchinson, M., & Olson, D. M. (2014). Toll-Like Receptor 4 (TLR4) Signalling Is Implicated in Normal On-Time Labour in Mice. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
2014 Bajic, J., Howarth, G., Eden, G., Lampton, L., Mashtoub, S., & Hutchinson, M. (2014). Intestinal mucositis induced by 5-fluorouracil results in spinal astrocyte expression changes in rats. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Broadbeach, Qld.: Wiley.
DOI
2014 Li, Y., Coller, J., Hutchinson, M., Klein, K., Zanger, U., Currow, D., . . . Somogyi, A. (2014). Cyp2B6*6 Allele Alters Ketamine'S Pharmacokinetics In Chronic Pain Patients And Metabolism In Vitro. Poster session presented at the meeting of Drug Metabolism Reviews. Toronto, CANADA: Informa Healthcare.
DOI
2013 Rolan, P., Hutchinson, M., Buijs, M., Tuke, J., Kwok, Y., Gentgall, M., . . . Nillsen, N. (2013). First demonstration of the neuroimmune link in humans using IV Endotoxin and Intradermal Capsaicin in the face and arm. Poster session presented at the meeting of JOURNAL OF HEADACHE AND PAIN. SPRINGER-VERLAG ITALIA SRL.
DOI
2013 Kwiatek, R., Hutchinson, M., Cleland, L., Limaye, V., True, B., Lubhan, C., . . . Coller, J. (2013). GENETIC VARIABILITY IN CYTOKINE AND CYTOKINE RECEPTORS IN FIBROMYALGIA - A PILOT STUDY. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013 Hutchinson, M. (2013). THE PROINFLAMMATORY HYPOTHESIS OF ADDICTION: CLINICAL AND PRECLINICAL EVIDENCE.. Poster session presented at the meeting of JOURNAL OF NEUROIMMUNE PHARMACOLOGY. SPRINGER.
2013 Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Codeine, Increasing Pain & Medication Overuse Headache: The First Evidence of Codeine-Induced Hyperalgesia. Poster session presented at the meeting of CEPHALALGIA. Boston, MA: SAGE PUBLICATIONS LTD.
2012 Zwicker, J. D., Zhang, Y., Hutchinson, M. R., Rice, K. C., Watkins, L. R., & Funk, G. D. (2012). Microglia attenuate the opioid-induced depression of preBotzinger Complex (preBotC) inspiratory rhythm in vitro via a TLR4-independent pathway. Poster session presented at the meeting of FASEB JOURNAL. San Diego, CA: FEDERATION AMER SOC EXP BIOL.
WoS1
2012 Narayan, D., Wood, J., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Casson, R. (2012). IMMUNE PRIMING AND EXPERIMENTAL GLAUCOMA: THE EFFECT OF PRIOR SYSTEMIC LIPOPOLYSACCHARIDE CHALLENGE ON TISSUE OUTCOMES AFTER OPTIC NERVE INJURY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL.

My research program has been funded by the following grant schemes

  • ARC discovery grant that includes an ARF (DP110100297; Sole CI)
  • NHMRC CJ Martin Postdoctoral Fellowship (Sole CI)
  • NHMRC project grant (APP1026178; CIB).
  • ARC Centre of Excellence for Nanoscale BioPhotonics ($38M, CE140100003)
  • NIH R01 grants as a PI (R01 DA034185; R01 DA025978; R01 DA23132; R01 DE017782)
  • USA Department of Defence CDMRP grant ($614K)
  • National Breast Cancer Foundation of Australia ($112K)
  • USA Fibromyalgia Association pilot grant ($55K)
  • ~$3M contract research on neuroimmune targeted therapies for pharmaceutical companies such as Phebra, Bionomics, Avigen, Covidien, Implicit Biosciences, NovImmune, Merck and J&J.

 

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Co-Supervisor Hypernociception in a Mouse Model of Inflammatory Arthritis Doctor of Philosophy Doctorate Full Time Miss Florence Jade Lees
2016 Principal Supervisor The Role of Nitroxyl (HNO) in Inflammation and Neuropathic Pain signaling Doctor of Philosophy Doctorate Full Time Mrs Vicky Staikopoulos
2015 Principal Supervisor The Effect of Sex on the Role of TLR4 in Chronic Pain Doctor of Philosophy Doctorate Full Time Samuel Greig Evans
2015 Principal Supervisor The Neuroimmunopharmacology of Dopaminergic System and their role in Neurodegenerative Diseases Doctor of Philosophy Doctorate Full Time Ms Krystal Lee Iacopetta
2015 Principal Supervisor Using Biophotonics to Examine Pain Processing Doctor of Philosophy Doctorate Full Time Mr Azim Arman
2014 Co-Supervisor MDMA Induced Hyperthermia - The Role of Monocyline on Core Body Temperature Doctor of Philosophy Doctorate Full Time Stefan Musolino
2014 Principal Supervisor The Interaction Between Stress and Alcohol Induced Neuroinflammation on Depressive-like Behaviour Doctor of Philosophy Doctorate Part Time Joshua Luke Holmes
2014 Principal Supervisor Assessing Glial Activation in Chemotherapy-Related Cognitive Impairment Doctor of Philosophy Doctorate Part Time Juliana Esma Bajic

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2014 - 2017 Principal Supervisor Exploring the Bidirectional Interface between Stress and Innate Immunity: A Focus on Glucocorticoid and TLR4-MyD88 Signalling Doctor of Philosophy Doctorate Full Time Dr Jiajun Liu
2014 - 2018 Co-Supervisor Investigating the role of Toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury Doctor of Philosophy Doctorate Full Time Sam Man Lee
2013 - 2017 Co-Supervisor Toll-Like Receptor 4 Signalling in Inflammation Pathways to Term and Preterm Delivery Doctor of Philosophy Doctorate Full Time Miss Hanan Hamimi Binti Wahid
2013 - 2017 Principal Supervisor Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours Doctor of Philosophy Doctorate Full Time Jonathan Henry Jacobsen
2011 - 2017 Principal Supervisor Neuroimmunopharmacology of Opioids Doctor of Philosophy Doctorate Full Time Dr Jacob Henry Lloyd Thomas
2010 - 2015 Co-Supervisor The thermal grill as a tool to investigate analgesic clinical pharmacology Doctor of Philosophy Doctorate Full Time Mrs Nicole Martha Sumracki
2010 - 2014 Co-Supervisor Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Doctor of Philosophy Doctorate Full Time Mr Yibai Li
2010 - 2015 Principal Supervisor Sex Differences in Allodynia: A complex Interaction Between 17beta-Oestradiol and the Innate Immune System Doctor of Philosophy Doctorate Full Time Miss Lauren Louise Nicotra
2010 - 2015 Co-Supervisor Codeine, heightened pain sensitivity and medication overuse headache: A neuroimmune hypothesis and novel treatment strategy. Doctor of Philosophy Doctorate Full Time Miss Jacinta Lee Johnson
2009 - 2014 Co-Supervisor Potential peripheral biomarkers for chronic pain Doctor of Philosophy Doctorate Full Time Miss Yuen Kwok
2009 - 2011 Co-Supervisor CNS Immune Signalling and Drug Addiction: Role of Interleukin-1 Beta Doctor of Philosophy Doctorate Full Time Mr Liang Liu
2008 - 2011 Co-Supervisor The Neuroimmunopharmacology of Alcohol Doctor of Philosophy Doctorate Full Time Miss Yue Wu
2007 - 2011 Co-Supervisor Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy Doctor of Philosophy Doctorate Full Time Mr Peter Grace

Board Memberships

Date Role Board name Institution name Country
2013 - ongoing Board Member Science Technology Australia Australia

Memberships

Date Role Membership Country
2012 - ongoing Member Australian Pain Society Australia
2007 - ongoing Member International Association for the Study of Pain United States
2007 - ongoing Member Psychoneuroimmunology Research Society United States
2002 - ongoing Member Society for Neuroscience United States
1999 - ongoing Representative Australasian Society for Clinical and Experimental Pharmacology and Toxicology Australia

Editorial Boards

Date Role Editorial Board Name Institution Country
2015 - ongoing Associate Editor Brain, Behavior, and Immunity
Position
Director - Centre for Nanoscale BioPhotonics
Phone
83130322
Fax
8224 0685
Campus
North Terrace
Building
The Braggs Buidling, floor 3
Room Number
3 10
Org Unit
Medical Sciences

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