Mr Samuel Evans

ARC Grant-Funded Postdoctoral Research Fellow

School of Pharmacy and Biomedical Sciences

College of Health


ECR with an interest in Toll-Like Receptor signalling and protein interactions. In particular their relevance to pathological pain and altered neural function.

My current work involves developing novel techniques for detection of immune signalling at the receptor level. This work aims improve our ability to study activation of innate immune receptors and the early stages of their signalling pathways. Innate immune receptors are important for numerous processes, from threat detection, reproduction, and nervous system function. Therefore, developing tools to better understand their mechanism of action has the potential to impact multiple fields, including, immunology and vaccine development, pain, addiction, and reproductive biology.

Previously, I worked with Toll-Like Receptors to investigate the relationship with neuronal ion channel TRPV1, attempting to understand the effect that immune signalling has on neural function. Known as neuroimmune signalling, these interactions are believed to play an important role in establishing and maintaining chronic pain. Unfortunately, effective treatment of chronic pain is currently lacking, and greater understanding of these mechanisms is a potential pathway to novel treatment strategies.

Date Position Institution name
2019 - ongoing Grant Funded Researcher University of Adelaide

Date Institution name Country Title
University of Adelaide, Adelaide Australia Bachelor of Health Science (Honours)
University of Adelaide, Adelaide Australia Bachelor of Science
University of Adelaide Australia PhD (Medicine)

Year Citation
2026 Evans, S. G., Buisman-Pijlman, F. T. A., Mustafa, S., & Hutchinson, M. R. (2026). Refining capsaicin-induced pain models: A comprehensive analysis of preclinical practices and their translational potential. Neuroscience and Biobehavioral Reviews, 180, 106455-1-106455-12.
DOI
2026 Aalders, M. B., van Marle, L., Evans, S. G., Lin, D. -Y. I., Wilson, C., Verjans, J. W., . . . Jaarsma, R. L. (2026). Protocol for assessment of pain biomarkers in orthopaedic patients undergoing total knee arthroplasty in a tertiary care hospital and neuroimmunopharmacology laboratory in South Australia: a cross-sectional matched-subject observational study. BMJ Open, 16(6), e117858-1-e117858-8.
DOI
2026 Laoumtzis, M., Evans, S. G., Barratt, D., Mustafa, S., & Hutchinson, M. R. (2026). Psychoneuroimmunology-informed strategies for early detection of biological threat exposure: Insights from experimental rodent models. Brain Behavior and Immunity, 138, 106933.
DOI
2025 Mustafa, S., Evans, S. G., & Hutchinson, M. R. (2025). Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics. Frontiers in Immunology, 16, 1580070-1-1580070-15.
DOI Scopus1 WoS1 Europe PMC1
2023 Mustafa, S., Bajic, J. E., Barry, B., Evans, S., Siemens, K. R., Hutchinson, M. R., & Grace, P. M. (2023). One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology.. Neuropharmacology, 228, 1-14.
DOI Scopus24 WoS22 Europe PMC21
2022 Han, M., Evans, S., Mustafa, S., Wiederman, S., & Ebendorff-Heidepriem, H. (2022). Controlled delivery of quantum dots using microelectrophoresis technique: intracellular behavior and preservation of cell viability. Bioelectrochemistry, 144, 108035-1-108035-9.
DOI
2021 Han, M., Zhao, J., Fabian, J. M., Evans, S., Mustafa, S., Ruan, Y., . . . Ebendorff-Heidepriem, H. (2021). Cytoplasmic delivery of quantum dots via microelectrophoresis technique. Electrophoresis, 42(11), 1247-1254.
DOI Scopus3 WoS4 Europe PMC2

Year Citation
2026 Johnston, C. H., Evans, S., Marini, D., Barratt, D. T., Mustafa, S., Agne, G. F., & Hutchinson, M. R. (2026). Pain in 4D: How Do Early Life Events Create Susceptibilities to Pain. In R. E. Clutten, & G. C. Musk (Eds.), Pain and Suffering in Farmed Animals: First Steps in Better Understanding and Management (pp. 137-162). Switzerland: Springer Nature Switzerland.
DOI
2022 Mustafa, S., Evans, S., Barry, B., Barratt, D., Wang, Y., Lin, C., . . . Hutchinson, M. R. (2022). Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems.. In V. Kumar (Ed.), Toll-like Receptors in Health and Disease. Handbook of Experimental Pharmacology (Vol. 276, pp. 239-273). Springer Berlin Heidelberg.
DOI Scopus3 WoS1 Europe PMC3

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