Research Interests
Central Nervous System Neurogenetics Neurology and Neuromuscular Diseases Neurosciences Peripheral Nervous System Preventive Medicine Regenerative Medicine Cardiac, Respiratory and Vascular Health Neuroscience, Behaviour and Brain Health Translational Health Outcomes Innovative TherapeuticsProf Simon Koblar
School of Medicine
College of Health
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Professor Koblar is a clinician-scientist with a national and international reputation in stroke and regenerative medicine, as well as in other disciplines including genetics, clinical neurology and developmental neurobiology. He has been appointed as the first Professor of Neurology and Neuroscience at the University of Adelaide in recognition of his significant and sustained scientific and clinical contributions. In 2005 he founded and continues to be Director of the Stroke Research Programme (SRP), which is a unique collaboration between the South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide, Basil Hetzel Institute for Translational Health Research, and two hospitals, The Queen Elizabeth (TQEH) and Royal Adelaide Hospitals (RAH). In 2015 SAHMRI was successful in being awarded one of four in the country NHMRC Advanced Health Research and Translation Centres, with stroke being one of the key thematic areas in collaboration with the SRP.Prof. Koblar was instrumental in founding the Adelaide Centre for Neuroscience Research (ACNR) and is its Director. The ACNR has brought together multidisciplinary researchers from many schools and faculties within the University of Adelaide. It also convenes the biannual Mount Lofty Workshop in the Adelaide Hills entitled ‘Frontier Technologies for Nervous System Function and Repair’. The 6th Mt Lofty Workshop was convened in 2014 and over the last decade the workshop has invited many leading neurologists, neurosurgeons, neuropathologists and neuroscientists from around Australia and internationally to participate. The ACNR and Mt Lofty Workshops have promoted leading edge neuroscience research within the University of Adelaide, which has led to national and international collaborations. His vision to bring together clinicians and scientists was fostered from his early academic experiences. His PhD was undertaken at the Walter and Eliza Hall Institute (WEHI), University of Melbourne during the directorship of Prof./Sir Gus Nossal and Prof. Koblar’s supervisor Prof. Perry Bartlett (formerly Director Queensland Brain Institute). He has an outstanding research profile of significant and sustained scientific contributions, having made six seminal discoveries, which are exemplified by several awards:1. Guillain-Barré syndrome (GBS): He was a Clinical Research Fellow at Guy’s Hospital, London, UK (1990-1992) under the mentorship of Prof. Richard Hughes and together they discovered the autoimmune basis of GBS. This led to a direct clinical translation with an antibody blood test now routinely used in the diagnosis of GBS. In 2004 he was sponsored by a co-author of the GBS discovery and then newly appointed director, Prof. Patrick Doherty, to undertake sabbatical leave at the Wolfson Centre for Age-Related Diseases, Guy’s Hospital, to advise as to the nexus of clinical and basic science research in Guy’s newest research institute. 2. Leukaemia Inhibitory Factor Receptor β (LIFRβ): During his PhD at WEHI, where the cytokine LIF had been discovered, Prof. Bartlett provided him an opportunity to investigate the first LIFRβ knockout mouse in collaboration with Immunex Ltd., a biotechnology company in Seattle, USA. From these investigations he discovered the essential role of LIFRβ signalling in neural differentiation. 3. Eph and ephrin family of genes: From 1996 to 1998 he was a Senior Post-doctoral Fellow at the University of Washington, Seattle with Prof. Mark Bothwell, co-discoverer of p75 the low affinity NGF receptor. He commenced research into a newly discovered family of genes the Eph/ephrins. In collaboration with other researchers in the USA he discovered the fundamental roles of a number of Eph/eprhin genes in development of the peripheral nervous system and also found a link to oncology. In 2001 his contribution to neuroscience research by a young neurologist was recognised by the Leonard Cox Award presented by the Australian and New Zealand Association of Neurologists. In 2002 his contribution to neuroscience research in the peripheral nervous system was recognised by the Sunderland Award presented by the University of Melbourne. 4. Genetics of Stroke: In 2004 he discovered that a genetic variation in the tPA gene was a risk for small vessel stroke (Ref. 9 and Patents in CV below). This was made in collaboration with one of his early PhD students, A/Prof. Jim Jannes, and also co-director of the SRP, A/Prof. Anne Hamilton-Bruce. From 2005 to 2010 the University of Adelaide and TQEH established a start-up biotechnology company – Atherogen Biotechnology Ltd. with inventors (Jannes, Koblar and Hamilton-Bruce). Atherogen Ltd. used this discovery to develop the concept of a genetic biomarker for small vessel cerebral disease. This initial genetic stroke research led to a strong collaboration with Prof. Christopher Levi, University of Newcastle, and together they set up the Australian Stroke Genetics Collaborative (ASGC). This collaboration subsequently led to a significant genetic discovery of a genetic risk for large vessel stroke, which was verified with collaborators from the International Stroke Genetics Consortium. 5. Npas4: In 2004 he published his second genetic discovery, isolating the gene Nxf (later renamed Npas4) using newly developed DNA microarray technology and found its association with neurological disease in collaboration with Prof. Grant Sutherland, an eminent Australian geneticist. From this research he collaborated with A/Prof. Yingxi Lin, Massachusetts Institute of Technology, USA and this led to further significant scientific contributions on the function of Npas4 in stroke and stem cell biology. 6. Dental Pulp Stem Cells (DPSC): In collaboration with Prof. Stan Granthos, who discovered DPSC in 2000, he hypothesized DPSC were a neural stem cell which he has established through published seminal discoveries demonstrating their ability to become neurons, influence neural plasticity and successfully treat a preclinical stroke model. In 2012 Mesoblast Ltd. in collaboration with the University of Adelaide patented the use of DPSC for the treatment of stroke. In 2011 his innovative research in regenerative medicine was recognised by the Leopold Dintenfass Award from the Rebecca L. Cooper Medical Research Foundation Ltd., NSW. Through his scientific and community leadership and industry interactions he proposed translating his basic stem cell research into a ‘first in human’ Phase 1 clinical trial in stroke patients using autologous DPSC in Australia. This has involved support from various groups: philanthropic organisations, the Peter Couche Foundation and Stroke SA, and industry, Mesoblast Ltd. and Boehringher-Ingelheim Corp., as well as research institutions SAHMRI and the University of Adelaide.He has been principal or co-investigator on research grants of over $16.8 M, which includes funding from the NHMRC, ARC and various philanthropic foundations. He is an author of more than 100 refereed scientific articles, book chapters, patents and expert reports with a H index of 23 (Google Scholar) and over 2500 citations. He has been a supervisor of 57 higher degree research students (2015 figure) with a strong track record of completion on time. His national and international profile is exemplified by invited presentations to over 80 local, national and international conferences and academic meetings. Two highlights in his career have been the plenary lecture on ‘Stem Cell Therapy in Stroke’ at the World Congress in Neurology 2011 (biannual conference) and he convened the 22nd Stroke Society of Australasia Conference in Adelaide SA in 2011. He is on the Editorial Boards of the high impact journals: International Journal of Stroke and Stem Cell Research and Therapy. He is regularly invited as an international reviewer of grant applications for the National Science Foundation (USA), Welcome Trust (UK), the Medical Research Council (UK) and medical research institutions in New Zealand. He was a member of the NHMRC Neuroscience Project Grant Review Panel from 2008 to 2012.He has a strong track record in medical education. He developed an innovative Neurology Teaching program at the University of Adelaide, which was recognised by the Allan Kerr Grant Award for Outstanding Teacher in 2003 and the Derek Frewin Citation for Clinical Teaching in 2010 and 2011. He established and chairs the MBBS Research Committee in the medical program at the University of Adelaide, which coordinates and innovates new approaches to stimulate medical student interaction and involvement in research. He has been an active member of the MBBS Curriculum Committee since 2011.Prof. Koblar has contributed significantly to the broader community in the field of stroke. In 2010 he helped establish the The Peter Couche Foundation, with Peter Couche and Mr Stephen Gerlach (Chancellor of Flinders University, SA), which is a philanthropic foundation having raised over $500,000 to fund innovative research in stroke. Since 2008 he has coordinated and provided media input during National Stroke Week, which has led to regular national media coverage, and increasing community awareness about stroke. He regularly provides local and national comment in the print, radio and television media on stroke related-issues.
Research Interests
Our major areas of current research are in stroke prevention, the molecular and cellular mechanisms underlying ischaemic stroke, and the translation of stroke management pathways in the clinical domain. We are currently involved in discovering a plasma protein/s which may tell the clinician when a patient is at risk of stroke following a transient ischaemic attack (TIA) so immediate treatment can be instigated. Stroke is the leading cause of adult disability and we aim to find out how to repair the brain following an ischaemic stroke. We have found that a stem cell from the tooth, Dental Pulp Stem Cell (DPSC), is able to general neurons and improve function when injected into the rodent brain following a stroke. There is a major need to understand the underlying mechanisms of stem cell therapy as different stem cells are used around the world in clinical trials. It is assumed that a neural stem cell maybe the optimum cell for therapy in the brain and so we are using molecular techniques to redirect DPSC into a neural stem cell. Finally, we research how to better translate stroke discoveries into the clinic for better patient outcomes.
Available Research Projects
Stroke Research Programme
Research Project 1 - FAST-IT Study – Investigation for a Plasma Biomarker for Transient Ischaemic Attack
Project description: Transient Ischaemic Attacks (TIA) result in transient neurological symptoms due to focal cerebral ischaemic and are an emergency with rapid diagnosis and treatment essential to reduce progression to a stroke. Currently, the diagnosis is very difficult and relies on clinical acumen with imaging of the brain helping to exclude a stroke. The discovery of a plasma protein which would be a biomarker for TIA would be an enormous advantage. This study will obtain patients from either the emergency department or the TIA rapid assessment clinic and document their clinical status with a blood sample taken within 48 hours of their presentation. The plasma samples will be interrogate using the latest Mass Spectrometry and proteomic tools to elucidate a protein which would be a biomarker of TIA.
Projects available for: Third Year / Honours / HDR / Masters / Mphil
Location: SAHMRI
Research project start: Semester 1 or 2
Special requirements: Nil
Research Project 2 - Investigation of Dental Pulp Stem Cells as a Treatment for Ischaemic Stroke
Project description: Dental Pulp Stem Cells (DPSC) are a neural/mesenchymal-type stem cell derived from the dental pulp of human molar teeth. We have demonstrated previously that DPSC are able to generate neurons in vitro and when implanted into the brain of a rat following an ischaemic stroke they have a positive impact improving disability following stroke. This research project will investigate further the neural potential of DPSC and when injected into the normal mouse brain how long the cells survive, where they migrate and what they differentiate into, whether neurons or glial cells.
Projects available for: Third Year / Honours / HDR / Masters / Mphil
Location: SAHMRI
Research project start: Semester 1 or 2
Special requirements: Vaccination to Hepatitis B required
| Date | Position | Institution name |
|---|---|---|
| 2015 - ongoing | Professor of Neurology and Neuroscience | University of Adelaide |
| 2015 - ongoing | Senior Consultant Neurologist (Clinical Academic) | Central Adelaide Local Health Network |
| 2013 - 2014 | Professor of Medicine | The University of Adelaide |
| 2009 - 2013 | Clinical Advisor – Centre for Stem Cell Research | Robinson Institute, University of Adelaide |
| 2009 - 2012 | Associate Professor of Medicine | The University of Adelaide |
| 2000 - 2008 | Team Leader – Molecular Neurobiology, ARC Centre of Excellence for the Molecular Genetics of Development | University of Adelaide |
| 2000 - 2008 | Senior Lecturer | University of Adelaide |
| 1998 - 1999 | NHMRC Peter Doherty Research Fellow | University of Adelaide |
| 1998 - 1999 | Head - Axon Guidance Laboratory | University of Adelaide |
| 1996 - 1998 | Senior Post-doctoral Fellow | University of Washington |
| 1992 - 1996 | NHMRC Post-Graduate Medical Scholarship | University of Melbourne |
| 1990 - 1991 | Clinical Research Fellow | United Medical & Dental Schools of Guy's & St. Thomas's Hospitals |
| 1989 - 1989 | Clinical Research Fellow | University of Turin |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2011 | Award | Leo Dintenfass Award | Rebecca L Cooper Medical Research Foundation Board | Australia | $5,500 |
| 1998 | Achievement | Certificate of Specialist Registration in Neurology | - | Australia | - |
| 1996 | Achievement | Doctor of Philosophy | University of Melbourne, Walter & Eliza Hall Institute of Medical Research | Australia | - |
| 1991 | Fellowship | FRACP | Royal Australian College of Physicians | Australia | - |
| 1984 | Achievement | MBBS | Flinders University of South Australia | - | - |
| Language | Competency |
|---|---|
| Italian | Can read, speak and understand spoken |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1992 - 1996 | The Walter & Eliza Hall Institute of Medical Research, University of Melbourne | Australia | PhD |
| 1991 | Royal Australasian College of Physicians | Australia | FRACP (Fellowship) |
| 1989 | United States of America | USA | U.S.A. Foreign Medical Graduates - practice certificate |
| 1984 | Flinders University of South Australia | Australia | BMBS |
| Date | Title | Institution | Country |
|---|---|---|---|
| 1998 - 2005 | Senior Visiting Specialist Neurologist | Queen Elizabeth Hospital | Australia |
| 1996 - 1997 | Visiting Overseas Fellow | University of Washington Medical Center | United States |
| 1992 - 1996 | Neurology Fellow | Monash Medical Centre | Australia |
| 1991 - 1991 | Senior Neurology Registrar | Queen Elizabeth Hospital | Australia |
| 1990 - 1990 | Neurology Registrar | Guy's Hospital | United Kingdom |
| 1988 - 1989 | Advanced Physician Trainee | Royal Adelaide Hospital | Australia |
| 1985 - 1987 | Basic Physician Trainee | Royal Adelaide Hospital | Australia |
| 1984 - 1984 | Internship | Royal Adelaide Hospital | Australia |
| Date | Title | Institution name | Country |
|---|---|---|---|
| 1998 | Certificate of Specialist Registration in Neurology # 3191 | Australian Government | Australia |
| 1989 | U.S.A. Foreign Medical Graduates - practice certificate | Educational Commission for Foreign Medical Graduates | United States |
| Year | Citation |
|---|---|
| 2023 | ESOC 2023 Abstract Book (2023). (Vol. 8). SAGE Publications. DOI |
| Year | Citation |
|---|---|
| 1995 | Bartlett, P. F., Richards, L. R., Kilpatrick, T. J., Talman, P. T., Bailey, K. A., Brooker, G. J., . . . Ford, M. O. (1995). Factors regulating the differentiation of neural precursors in the forebrain.. In G. R. Bock, & G. Cardew (Eds.), Unknown Book (Vol. 193, pp. 85-126). JOHN WILEY & SONS LTD. DOI Scopus14 WoS15 Europe PMC8 |
| 1995 | Bartlett, P. F., Richards, L. R., Kilpatrick, T. J., Talman, P. T., Bailey, K. A., Brooker, G. J., . . . Ford, M. O. (1995). Factors regulating the differentiation of neural precursors in the forebrain.. In G. R. Bock, & G. Cardew (Eds.), Unknown Book (Vol. 193, pp. 85-126). JOHN WILEY & SONS LTD. DOI Scopus14 WoS15 Europe PMC8 |
| Year | Citation |
|---|---|
| 2023 | Lau, S., Sharma, D., Rao, S., Snel, M., Milton, A., Edwards, S., . . . Hamilton-Bruce, A. (2023). Proteomics-based classification of transient ischaemic attacks, mimics and healthy controls using machine learning. In European Stroke Journal Vol. 8 (pp. 624-625). Munich, Germany. DOI |
| 2022 | Sharma, D., Rao, S., Snel, M., Lau, S., Edwards, S., Mahadevan, J., . . . Koblar, S. (2022). FAST-IT: Finding A Simple Test In TIA (Transient Ischaemic Attack): A pilot study at the Royal Adelaide Hospital. In INTERNATIONAL JOURNAL OF STROKE Vol. 17 (pp. 33-34). SAGE PUBLICATIONS LTD. |
| 2021 | Nagpal, A., Milton, A., Hamilton-Bruce, A., & Koblar, S. (2021). CRITICAL DETERMINANTS OF SUCCESSFUL TRANSLATION OF CELL THERAPIES IN ISCHAEMIC STROKE: A REVIEW. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 121). SAGE PUBLICATIONS LTD. |
| 2021 | Milton, A. G., Lau, S., Edwards, S., Duvenage, H. A., Djukic, M., Snel, M., . . . Hamilton-Bruce, M. A. (2021). Searching for de novo Transient Ischemic Attack (TIA) biomarkers using new-generation mass spectrometry. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 22). SAGE PUBLICATIONS LTD. |
| 2021 | Sharma, D., Koblar, S. A., & Hamilton-Bruce, M. A. (2021). Biomarkers for Transient Ischaemic Attacks (TIAs): A review. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 28). SAGE PUBLICATIONS LTD. |
| 2021 | Hamilton-Bruce, M. A., Hazel, S. J., Young, J. O., Nottle, C., Milton, A. G., Kinnear, L., . . . Koblar, S. A. (2021). DOgSS: An action research protocol for dogs offering support after stroke. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 12). SAGE PUBLICATIONS LTD. |
| 2020 | Milton, A. G., Kremer, K. L., Rao, S. R., Mas, E., Snel, M. F., Trim, P. J., . . . Hamilton-Bruce, M. A. (2020). A Prospective Cohort Study to Develop and Validate a Multivariable Prediction Model for Transient Ischaemic Attack (TIA) Diagnosis Using Proteomic Discovery and Candidate Lipid Mass Spectrometry, Neuroimaging and Machine Learning: Study Protocol. In Abstracts of the Annual Conference of the Asia Pacific Stroke Organization (APSO 2020), as published in Cerebrovascular Diseases Vol. 49 (pp. 72). Korea: Karger. DOI |
| 2019 | Kleinig, T., Cheong, E., Harvey, J., Cagi, L., Cranefield, J., Koblar, S., . . . Campbell, B. (2019). Head-down position improves blood flow in acute stroke measured by CT perfusion (CTP): interim results of the Head-START study. In INTERNATIONAL JOURNAL OF STROKE Vol. 14 (pp. 4). SAGE PUBLICATIONS LTD. |
| 2019 | Nagpal, A., Hamilton-Bruce, A., Milton, A. G., & Koblar, S. (2019). Clinical Translation of Cell Therapies in Stroke (CT2S) Checklist - a tool to accelerate cell therapy research in academic setting. In INTERNATIONAL JOURNAL OF STROKE Vol. 14 (pp. 25). SAGE PUBLICATIONS LTD. |
| 2018 | Lillicrap, T., Harman, S., Draxler, D., Niego, B., Ho, H., McCutcheon, F., . . . Medcalf, R. (2018). Ex-vivo generation of plasmin from patients with acute ischaemic stroke is predictive of successful thrombolysis. In INTERNATIONAL JOURNAL OF STROKE Vol. 13 (pp. 4). SAGE PUBLICATIONS LTD. |
| 2018 | Milton, A. G., Kleinig, T., Young, A. -M., Nagpal, A., Kim, S., Koblar, S. A., . . . Jannes, J. (2018). Central Adelaide Local Health Network - Stroke Unit Access Update. In INTERNATIONAL JOURNAL OF STROKE Vol. 13 (pp. 47). SAGE PUBLICATIONS LTD. |
| 2016 | Ebert, L., Tan, L. Y., Min, K. K. M., Cockshell, M., Johan, M. Z., Parham, K., . . . Bonder, C. (2016). Desmoglein 2 (DSG2) is a novel surface marker of endothelial and haematopoietic progenitor cells, and plays a critical role in neoangiogenesis. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 309). Melbourne, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Moey, A., Hamilton-Bruce, M., Howell, S., Leyden, J., Chong, W., Dodd, L., . . . Jannes, J. (2015). Significant increase in thrombolysis therapy rates for stroke in South Australia. In International Journal of Stroke Vol. 10 (pp. E49). England: Wiley. DOI Scopus2 WoS4 Europe PMC2 |
| 2015 | Majd, S., Grantham, H., Koblar, S., Rayner, T., & Power, J. (2015). Developing an animal model of global brain ischemia through cardiac arrest. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 325). Cairns, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | Majd, S., Grantham, H., Power, J., & Koblar, S. (2015). Effect of global brain ischeima after cardiac arrest oin producing the hallmarks of Alzheimer's disease. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 275). Cairns, AUSTRALIA: WILEY-BLACKWELL. |
| 2014 | Tsiminis, G., Klarić, T., Schartner, E., Warren-Smith, S., Lewis, M., Koblar, S., & Monro, T. (2014). Fibre-optic photochemical stroke: generating and measuring photochemical changes inside the brain. In J. LopezHiguera, J. Jones, M. LopezAmo, & J. Santos (Eds.), Proceedings of SPIE - The International Society for Optical Engineering Vol. 9157 (pp. 9157D4-1-9157D4-4). US: SPIE. DOI Scopus1 |
| 2011 | Arthur, A., Panagopoulos, R., Cooper, L., Zannettino, A., Koblar, S. A., Sims, N. A., . . . Gronthos, S. (2011). THE ROLE OF EPHB/EPHRINB MOLECULES IN FRACTURE REPAIR. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S523). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD. |
| 2009 | Arthur, A., Stylianou, C., Koblar, S. A., Matsuo, K., & Gronthos, S. (2009). EphB/ephrin-B interactions assist in MSC niche maintenance and contribute to bone remodelling following injury. In BONE Vol. 44 (pp. S142-S143). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI |
| 2007 | Arthur, A., Koblar, S., & Gronthos, S. (2007). The role of EphB/ephrin-B interactions in cell attachment and spreading of mesenchymal precursors derived from human bone marrow and dental pulp tissues. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S370-S371). Honolulu, HI: AMER SOC BONE & MINERAL RES. |
| 2003 | Jayasena, C. S., & Koblar, S. A. (2003). Investigating the role of Eph/ephrin-A during trigerninal ganglion axon guidance.. In DEVELOPMENTAL BIOLOGY Vol. 259 (pp. 590). BOSTON, MASSACHUSETTS: ACADEMIC PRESS INC ELSEVIER SCIENCE. |
| Year | Citation |
|---|---|
| 2023 | Hamilton-Bruce, M. A., Young, J., Hazel, S. J., Koblar, S. A., Milton, A. G., Nottle, C., . . . Mani, B. (2023). Dogs Offering Support after Stroke (DOgSS) - Animal Assisted Intervention Action Research at the Royal Adelaide Hospital’s Stroke Unit. Poster session presented at the meeting of Abstracts of Stroke 2023 - The Combined Stroke Society of Australasia and Smart Strokes Nursing and Allied Health Scientific Meeting, as published in International Journal of Stroke. Melbourne, Australia: SAGE Publications. DOI WoS2 |
| 2021 | Bacchi, S., Oakden-Rayner, L., Menon, D. K., Moey, A., Jannes, J., Kleinig, T., & Koblar, S. (2021). STROKE PROGNOSTICATION FOR DISCHARGE PLANNING WITH MACHINE LEARNING: DERIVATION, PROSPECTIVE VALIDATION AND EXTERNAL VALIDATION. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY. |
| 2019 | Milton, A., Harvey, J., Edwards, S., Young, A. -M., Dodd, L., Hampton, C., . . . Koblar, S. (2019). Central Adelaide Local Health Network (CALHN) Stroke Unit (SU) administrative data and Stroke Clinical Registry data analyses. Poster session presented at the meeting of International Journal of Stroke. Canberra, Australia: International Journal of Stroke. |
| 2018 | Nagpal, A., Milte, R., Kim, S. W., Hillier, S., Milton, A. G., Hamilton-Bruce, M. A., . . . Koblar, S. A. (2018). Economic evaluation of stem cell therapies in neurological diseases: a systematic review. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. SAGE PUBLICATIONS LTD. |
| 2018 | Levi, C., Lillicrap, T., Harman, S., Draxler, D., Niego, B., Ho, H., . . . Medcalf, R. (2018). EX-VIVO GENERATION OF PLASMIN FROM PATIENTS WITH ACUTE ISCHAEMIC STROKE IS PREDICTIVE OF SUCCESSFUL THROMBOLYSIS. Poster session presented at the meeting of JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. Darwin, AUSTRALIA: BMJ PUBLISHING GROUP. DOI |
| 2017 | Goldsmith, K., Balabanski, A., Giarola, B., Buxton, D., Castle, S., McBride, K., . . . Kleinig, T. (2017). Excessive stroke incidence in Aboriginal people in Central Australia: a retrospective population-based study. Poster session presented at the meeting of Abstracts of the RACP Congress 2017 - Bringing Specialists Together. Sharing Knowledge. Building Skills, as published in Internal Medicine Journal. Melbourne, VIC: Wiley-Blackwell. DOI WoS2 |
| 2017 | Pandos, O., Nagpal, A. N., Milton, A., Kleinig, T., Jannes, J., Koblar, S., & Hamilton-Bruce, M. A. (2017). Legislative requirements increase availability of access to certified stroke unit care. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. SAGE PUBLICATIONS LTD. |
| 2017 | Milton, A., Kleinig, T., Nagpal, A., Young, A. -M., Kim, S., Koblar, S. A., . . . Jannes, J. (2017). Stroke unit access update. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. SAGE PUBLICATIONS LTD. |
| 2017 | Balabanski, A., Goldsmith, K., Giarola, B., Buxton, D., Castle, S., McBride, K., . . . Kleinig, T. (2017). Excessive stroke incidence in Aboriginal people in Central Australia: a retrospective population-based study. Poster session presented at the meeting of Abstracts of the 27th Annual Scientific Meeting of the Stroke Society of Australasia, as published in International Journal of Stroke. Queenstown, New Zealand: SAGE Publications. DOI |
| 2016 | Foyle, K., Wilson, J., Koblar, S., McColl, S., & Comerford, I. (2016). Dental pulp stem cells inhibit encephalitogenic T cell responses and suppress disease in an animal model of multiple sclerosis. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL. |
| 2016 | Carson, K. V., Brinn, M. P., Peters, M. J., Fitridge, R., Koblar, S. A., Jannes, J., . . . Smith, B. J. (2016). SUPERIORITY OF A COURSE OF VARENICLINE TARTRATE PLUS COUNSELLING OVER COUNSELLING ALONE FOR SMOKING CESSATION: A 24-MONTH RANDOMISED CONTROLLED TRIAL FOR INPATIENTS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. |
| 2016 | Goldsmith, K., Balabanski, A., Giarola, B., Buxton, D., Castle, S., McBride, K., . . . Kleinig, T. (2016). Excessive stroke incidence in Aboriginal people in Central Australia: a retrospective population-based study. Poster session presented at the meeting of Abstracts of the 10th World Stroke Congress, as published in International Journal of Stroke. Hyderabad, INDIA: SAGE Publications. DOI |
| 2016 | Asia Pacific Stroke Conference 2016. Abstracts of the Annual Conference of theAsia Pacific Stroke Organization (APSO) Combined with Stroke Society of Australasia, Brisbane, Qld., Australia, July 14-17, 2016: Abstracts (2016). Poster session presented at the meeting of Cerebrovascular Diseases. S. Karger AG. DOI |
| 2016 | Hamilton-Bruce, A., Milton, A., Miller, S., Kleinig, T., Jannes, J., & Koblar, S. (2016). Transforming Stroke Research in South Australia - A Management Program to Support Change. Poster session presented at the meeting of CEREBROVASCULAR DISEASES. KARGER. |
| 2016 | Goldsmith, K., Balabanski, A., Giarola, B., Buxton, D., Castle, S., McBride, K., . . . Kleinig, T. (2016). Comparison of Aboriginal and Non-Aboriginal Stroke in Central Australia: A Retrospective Cohort Study. Poster session presented at the meeting of CEREBROVASCULAR DISEASES. KARGER. |
| 2016 | Hamilton-Bruce, A., Kleinig, T., Royle, E., Milton, A., Koblar, S., & Jannes, J. (2016). Quantifying and Overcoming Barriers to Stroke Unit Access. Poster session presented at the meeting of CEREBROVASCULAR DISEASES. KARGER. |
| 2016 | Carson, K., Brinn, M., Peters, M., Fitridge, R., Koblar, S., Jannes, J., . . . Smith, B. (2016). SUPERIORITY OF A COURSE OF VARENICLINE TARTRATE PLUS COUNSELLING OVER COUNSELLING ALONE FOR SMOKING CESSATION: A 24-MONTH RANDOMISED CONTROLLED TRIAL FOR INPATIENTS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. WoS3 |
| 2015 | Hamilton-Bruce, A. M., Milton, A. G., Koblar, S. A., & MacFarlane, P. (2015). Stroke and exceptions from informed consent (EFIC): Literature review. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2015 | Hamilton-Bruce, A. M., Milton, A. G., Koblar, S. A., & MacFarlane, P. (2015). Stroke and Exceptions from Informed Consent (EFIC): Exploring the interface between law, ethics and clinical research. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. WoS1 |
| 2015 | Koblar, S., Gronthos, S., & Shi, S. (2015). Stem cell therapy in stroke - human dental pulp stem cells from basic science to a clinical trial. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2014 | Djukic, M., Milton, A. G., Hamilton-Bruce, A. M., Lewis, M. D., Leung, E., Jannes, J., . . . Koblar, S. A. (2014). Targeted peptide quantification of candidate plasma proteins to diagnose Transient Ischaemic Attack (TIA). Poster session presented at the meeting of Abstracts of the 25th Annual Scientific Meeting of the Stroke Society of Australasia, as published in International Journal of Stroke. Hamilton Island, Qld.: Wiley-Blackwell. DOI WoS1 |
| 2014 | Hamilton-Bruce, A. M., Hazel, S., Krawczyk, V. J., Milton, A. G., & Koblar, S. A. (2014). Exploration of ethological issues in Animal Assisted Interventions (AAI) for stroke sufferers: Recommendations for action. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2013 | Appleton, S., Biermann, S., Hamilton-Bruce, M. A., Piantadosi, C., Tucker, G., Koblar, S. A., & Adams, R. (2013). Health literacy (HL) mediates the relationship of socioeconomic status (SES) and stroke in a population sample. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2013 | Krawczyk, V. J., Crichton, J., Hamilton-Bruce, M. A., & Koblar, S. A. (2013). Perspectives on language, medicine and the human body in a multidisciplinary biomedical research group. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2013 | Hamilton-Bruce, M. A., Gowland, J., Hazel, S., & Koblar, S. A. (2013). Animal assisted therapy (AAT) for stroke victims: the need for objective assessment?. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2013 | Leong, W. K., Klaric, T. S., Lin, Y., Koblar, S. A., & Lewis, M. D. (2013). Npas4 upregulation in the corticolimbic system in stroke: implications for post-stroke depression. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2013 | Milton, A. G., Hamilton-Bruce, M. A., Jannes, J., & Koblar, S. A. (2013). Phosphodiesterase 4D (PDE4D) and stroke: heterogeneity of studies. Poster session presented at the meeting of 24th Annual Scientific Meeting of the Stroke Society of Australia, as published in International Journal of Stroke. Darwin, Australia: Wiley. DOI |
| 2012 | Koblar, S. (2012). Stem Cell Therapy in Stroke-2012 Update. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2012 | Koblar, S., Djukic, M., Lewis, M. D., Leung, E., Jannes, J., Hamilton-Bruce, M. A., & Chataway, T. (2012). Candidate Plasma Biomarkers for Transient Ischaemic Attack (TIA). Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2012 | Hamilton-Bruce, M. A., & Koblar, S. (2012). Genetic testing - operational framework changes needed?. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2012 | Moey, A., Jannes, J., Koblar, S., Leyden, J., Kleinig, T., Lee, A., & Chong, K. (2012). Thrombolysis for Acute Stroke in South Australia: Have We Improved?. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF STROKE. WILEY-BLACKWELL. |
| 2005 | Jannes, J., Milton, A., HAMILTON-BRUCE, M. A., & KOBLAR, S. A. (2005). Chloride channel gene polymorphism and stroke. Poster session presented at the meeting of Journal of Neurological Sciences. Sydney, AUSTRALIA: Elsevier. DOI |
| Year | Citation |
|---|---|
| 2019 | Authors: Milton A, Kremer K, Rao S, Trim P, Snel M, Kleinig T, Jannes J, Koblar S. Title: FAST-IT TIA Biomarker Study. Extent: Poster and Oral presentation (AGM). |
| 1996 | Authors: Koblar SA. Title: Regulation of Neural Differentiation (PhD Thesis). Extent: PhD Thesis. |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2021 | Co-Supervisor | FAST-IT Study: Investigation for Plasma Biomarkers for Transient Ischaemic Attack | Doctor of Philosophy | Doctorate | Part Time | Deeksha Sharma |
| 2021 | Co-Supervisor | FAST-IT Study: Investigation for Plasma Biomarkers for Transient Ischaemic Attack | Doctor of Philosophy | Doctorate | Part Time | Deeksha Sharma |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2019 - 2022 | Principal Supervisor | Deep Learning in the Prediction of Clinically Significant Outcomes in Stroke and General Medicine Patients | Doctor of Philosophy | Doctorate | Part Time | APrf Stephen Daniel Bacchi |
| 2016 - 2021 | Principal Supervisor | Investigating Reprogramming Factors and Neural Conditions to Convert Human Dental Pulp Stem Cells into Neural Stem Cells | Doctor of Philosophy | Doctorate | Full Time | Miss Maria Roumenova Gancheva |
| 2015 - 2019 | Principal Supervisor | Exploring Determinants of Execution in Early Phase Clinical Studies with Cell Therapies in Stroke | Doctor of Philosophy | Doctorate | Full Time | Dr Anjali Nagpal |
| 2014 - 2020 | Co-Supervisor | Characterisation of human dental pulp stem cells in an animal model of multiple sclerosis | Doctor of Philosophy | Doctorate | Full Time | Dr Kerrie Louise Foyle |
| 2013 - 2018 | Principal Supervisor | Molecular and Cellular Investigations Relating to Neuroplasticity in Stroke | Doctor of Philosophy | Doctorate | Full Time | Mr Joshua Nathan Winderlich |
| 2012 - 2014 | Principal Supervisor | Investigation of p75 neurotrophin receptor on human Dental Pulp Stem Cells (hDPSC) | Master of Medical Science | Master | Full Time | Miss Wenru Pan |
| 2012 - 2015 | Co-Supervisor | The Role of Npas4 in Neuroprotection and Neurogenesis | Doctor of Philosophy | Doctorate | Full Time | Mr Fong Chan Choy |
| 2010 - 2014 | Co-Supervisor | Neurophysiology and Electrophysiology of Human and Murine Dental Pulp Stem Cells | Doctor of Philosophy | Doctorate | Full Time | Miss Kylie Maree Ellis |
| 2009 - 2017 | Principal Supervisor | Proteomic Investigations and Biomarker Discovery in Transient Ischaemic Attack | Doctor of Philosophy | Doctorate | Full Time | Mr Michael Djukic |
| 2009 - 2012 | Principal Supervisor | Stem Cell and Molecular Investigations Following Focal Cerebral Ischemia | Doctor of Philosophy | Doctorate | Full Time | Miss Wai Khay Leong |
| 2009 - 2015 | Principal Supervisor | Transient Ischaemic Attack: A Primary Care Perspective of Stroke Prevention | Doctor of Philosophy | Doctorate | Part Time | Dr Elaine Leung |
| 2008 - 2014 | Co-Supervisor | Expression and functional analysis of SOX3 in murine neurogenesis | Doctor of Philosophy | Doctorate | Full Time | Mr Nicholas Alan Rogers |
| 2006 - 2011 | Co-Supervisor | Identification of Downstream Target Genes and Analysis of Obesity-Related Variants of the bHLH/PAS Transcription Factor Single-Minded 1 | Doctor of Philosophy | Doctorate | Full Time | Miss Anne Raimondo |
| 2006 - 2010 | Co-Supervisor | Endothelial Function & Genetic Polymorphisms in Cerebral Small Vessel Disease | Doctor of Philosophy | Doctorate | Full Time | Miss Ada Lam |
| 2006 - 2012 | Principal Supervisor | Expression and Function of Npas4 During Early Development | Doctor of Philosophy | Doctorate | Full Time | Dr Tom Klaric |
| 2005 - 2008 | Co-Supervisor | Analysis of Genes Implicated in Alzheimer's Disease Pathogenesis Using Danio Rerio as a Model Organism | Doctor of Philosophy | Doctorate | Full Time | Dr Morgan Newman |
| 2003 - 2007 | Principal Supervisor | Guidance and Neuronal Properties of Dental Pulp Stem Cells | Doctor of Philosophy | Doctorate | Full Time | Dr Agnes Arthur |
| 2003 - 2007 | Co-Supervisor | The Contribution of Periodontal Mechanoreceptors to Physiological Tremor in the Human Jaw | Doctor of Philosophy | Doctorate | Full Time | Mr Paul Sowman |
| 2002 - 2006 | Co-Supervisor | The Pathophysiology of the Coronary Slow Flow Phenomenon | Doctor of Philosophy | Doctorate | Full Time | Dr Stuart Turner |
| 2002 - 2005 | Principal Supervisor | Investigating the Role of EphA/ ephrin-A Signalling During Trigeminal Ganglion Axon Guidance | Doctor of Philosophy | Doctorate | Full Time | Ms Chathurani Jayasena |
| 2002 - 2011 | Co-Supervisor | An Investigation into the Development and Patterning of Dorsal Longitudinal Ascending Interneurons in Danio Rerio | Doctor of Philosophy | Doctorate | Full Time | Dr Simon Wells |
| 2000 - 2005 | Principal Supervisor | EphA4 and ephrin-A interactions in avian neural crest cell segmentation | Doctor of Philosophy | Doctorate | Full Time | Dr Edwina Sutton |
| 2000 - 2004 | Principal Supervisor | Polygenic Disease: A Study of Genetic Risk in an Australian Stroke Population | Doctor of Philosophy | Doctorate | Full Time | APrf Jim Jannes |
| 1999 - 2003 | Co-Supervisor | MOLECULAR CHARACTERISATION OF TRANSLOCATIONS INVOLVING CHROMOSOME BAND 1p36 IN ACUTE MYELOID LEUKAEMIA | Doctor of Philosophy | Doctorate | Full Time | Mr Christopher Ian Slape |
| 1998 - 2003 | Principal Supervisor | Investigations of ephrin ligands during development | Doctor of Philosophy | Doctorate | Full Time | Mr Paul Tosch |
| Date | Role | Board name | Institution name | Country |
|---|---|---|---|---|
| 2005 - 2008 | Board Member | Brain Foundation (SA) Ltd | - | - |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2016 - ongoing | Member | National Stroke Foundation Research Advisory Committee | - | - |
| 2012 - ongoing | Board Member | University of Adelaide Medical School MBBS Research Committee | University of Adelaide | - |
| 2011 - ongoing | Member | University of Adelaide Medical School Curriculum Committee | University of Adelaide | - |
| 2011 - ongoing | Member | National Stroke Foundation Clinical Council | National Stroke Foundation | Australia |
| 2010 - ongoing | Chair | Stroke SA Network TIA Workgroup | Stroke SA Network | Australia |
| 2009 - ongoing | Member | Stroke SA Network Steering Committee | Stroke SA Network | - |
| 2006 - ongoing | Chair | Nervous System Review Group (Faculty of Health Science) | University of Adelaide | - |
| 2001 - 2003 | Member | South Australian Italian Medical Association Committee | - | - |
| 2000 - 2001 | Board Member | Curriculum Committee, Faculty of Health Science | University of Adelaide | - |
| Date | Role | Membership | Country |
|---|---|---|---|
| 2009 - ongoing | Member | Stroke Society of Australasia | - |
| 2006 - 2009 | Chair | South Australian Stroke Unit Network | - |
| 2003 - 2003 | President | Cairns Neurological Society (SA) | - |
| 2001 - 2003 | Secretary | Cairns Neurological Society (SA) | - |
| 2000 - 2000 | Treasurer | Cairns Neurological Society (SA) | - |
| 1998 - ongoing | Member | South Australian Italian Medical Association | - |
| 1998 - ongoing | Member | Cairns Neurological Society (SA) | - |
| 1998 - ongoing | Member | Mortality Review Committee, The Queen Elizabeth Hospital | Australia |
| 1997 - ongoing | Member | Society for Neuroscience | United States |
| 1992 - ongoing | Member | Australian Neuroscience Society | - |
| 1991 - ongoing | Member | Australian and New Zealand Association Neurology | - |
| Date | Institution | Department | Organisation Type | Country |
|---|---|---|---|---|
| 2016 - 2016 | THERAPEUTIC GOODS ADMINISTRATION | Stroke Research Programme, University of Adelaide, Adelaide, South Australia | - | - |
| 2016 - 2016 | Scientific Methods (Nature Publishing Group) (Impact Factor 5.288) | - | - | - |
| 2016 - ongoing | International Journal of Stroke, the official journal of the World Stroke Organization; impact factor 4.3 (2014 Thomson Reuters) | - | Scientific research | - |
| 2016 - 2016 | a Hindawi Press journal, impact factor 2.813 (2014 Thomson Reuters) | Stem Cells International | - | - |
| 2016 - 2016 | World Stroke Organisation | - | - | - |
| 2010 - ongoing | University of Adelaide | Peter Couche Foundation | - | Australia |
| 2008 - ongoing | University of Adelaide | Adelaide Centre for Neuroscience Research | - | Australia |
| 2008 - 2012 | National Health & Medical Research Council | - | - | - |
| 2007 - 2011 | Queen Elizabeth Hospital | Basil Hetzel Institute | - | Australia |
| 2006 - 2009 | Australian Stroke Unit Network | - | - | - |
| 2006 - ongoing | University of Adelaide | Mt Lofty Workshop ‘Frontier Technologies for Nervous System Function and Repair’ | - | Australia |
| 2006 - ongoing | University of Adelaide | Centre Stem Cell Research, Robinson Institute | - | Australia |
| 2005 - ongoing | South Australian Neuroscience Institute | - | - | Australia |
| 2005 - ongoing | University of Adelaide | Computational Neuroscience Research Cluster | - | Australia |
| 2005 - 2010 | Research Network in Genes and Environment in Development | - | - | Australia |
| 2003 - 2005 | SA Health and Medical Research Advisory Council | - | - | - |
| 2000 - ongoing | University of Adelaide | Adelaide Microarray Facility | - | Australia |
| 2000 - 2001 | University of Adelaide | Faculty of Health Science | - | Australia |
| 1998 - 1998 | Australian and New Zealand Society for Cell & Developmental Biology | - | - | Australia |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2013 - ongoing | Board Member | Stem Cell Research and Therapy | - | - |
| 2010 - ongoing | Board Member | International Journal of Stroke | - | - |
| Date | Office Name | Institution | Country |
|---|---|---|---|
| 2008 - ongoing | Patron | Stroke SA Ltd. | Australia |