Agnes Arthur

Dr Agnes Arthur

Research Group Leader - (MCC)

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Skeletal disease such as osteoporosis is caused by the uncoupling of the bone remodelling process. This uncoupling causes the deterioration of the skeleton by a decrease in the production and thus function of bone forming cells and the increase of bone removing cells. This imbalance ultimately results in more brittle bones that have a higher incidence of fracture. Osteoporosis affects over 2 million Australians and costs the health system approximately $20 million/day. With such high prevalence and cost to the Australian health system, it is imperative that we identify novel therapies that limit side effects while treating osteoporosis effectively.

I lead the Musculoskeletal Cellular Communication (MCC) research group within the Mesenchymal Stem Cell (MSC) Laboratory. My group is interested in understanding the communication between MSC and their surrounding microenvironment. This communication is important during (1) bone remodelling, (2) bone disease and (3) repair following trauma. My research focuses on the function of a family of receptor tyrosine kinase molecules, the Eph receptors and ephrin ligands expressed by MSC and within their microenvironment. The projects aim to decipher the function of ephrinB1 on the skeletal stem cells and their derivatives during bone development, postnatal skeletal homeostasis/remodelling, during the onset of osteoporosis and following fracture repair. The research also aims to identify the signalling mechanisms by which ephrinB1/EphB molecules mediate their responses during these processes. This approach could potentially translate into alternative therapeutic treatments for patients with osteoporosis, to prevent fractures in high risk groups.

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  • Journals

    Year Citation
    2021 Abeynayake, N., Arthur, A., & Gronthos, S. (2021). Crosstalk between skeletal and neural tissues is critical for skeletal health. Bone, 142, 1-13.
    DOI Scopus3 WoS4 Europe PMC3
    2021 Arthur, A., & Gronthos, S. (2021). Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment. Frontiers in Cell and Developmental Biology, 9, 19 pages.
    DOI WoS1 Europe PMC1
    2021 Tangseefa, P., Martin, S. K., Arthur, A., Panagopoulos, V., Page, A. J., Wittert, G. A., . . . Zannettino, A. C. W. (2021). Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary-Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice. JBMR Plus, 5(5), e10486.
    DOI
    2021 Barker, A. J., Arthur, A., DeNichilo, M. O., Panagopoulos, R., Gronthos, S., Anderson, P. J., . . . Panagopoulos, V. (2021). Plant-derived soybean peroxidase stimulates osteoblast collagen biosynthesis, matrix mineralization, and accelerates bone regeneration in a sheep model. Bone Reports, 14, 101096.
    DOI
    2020 Arthur, A., & Gronthos, S. (2020). Clinical application of bone marrow mesenchymal stem/stromal cells to repair skeletal tissue. International Journal of Molecular Sciences, 21(24), 9759-1-9759--28.
    DOI Scopus4 WoS5 Europe PMC3
    2020 Arthur, A., Paton, S., Zannettino, A. C. W., & Gronthos, S. (2020). Conditional knockout of ephrinB1 in osteogenic progenitors delays the process of endochondral ossification during fracture repair. Bone, 132, 115189-1-115189-10.
    DOI Scopus3 WoS2 Europe PMC2
    2019 Arthur, A., Nguyen, T. M., Paton, S., Zannettino, A. C. W., & Gronthos, S. (2019). Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance. Experimental Hematology, 69, 43-53.
    DOI Scopus7 WoS7 Europe PMC4
    2018 Arthur, A., Nguyen, T., Paton, S., Klisuric, A., Zannettino, A., & Gronthos, S. (2018). The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption. Scientific Reports, 8(1), 12756-1-12756-12.
    DOI Scopus5 WoS5 Europe PMC2
    2017 Hemming, S., Cakouros, D., Codrington, J., Vandyke, K., Arthur, A., Zannettino, A., & Gronthos, S. (2017). EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture & structural integrity and accelerates remodeling. FASEB Journal, 31(3), 1011-1027.
    DOI Scopus35 WoS33 Europe PMC23
    2017 Nguyen, T., Arthur, A., Zannettino, A., & Gronthos, S. (2017). EphA5 and EphA7 forward signaling enhances human hematopoietic stem and progenitor cell maintenance, migration, and adhesion via Rac1 activation. Experimental Hematology, 48, 72-78.
    DOI Scopus10 WoS9 Europe PMC6
    2017 Tomokiyo, A., Hynes, K., Ng, J., Menicanin, D., Camp, E., Arthur, A., . . . Mark Bartold, P. (2017). Generation of Neural Crest-Like Cells From Human Periodontal Ligament Cell-Derived Induced Pluripotent Stem Cells. Journal of Cellular Physiology, 232(2), 402-416.
    DOI Scopus9 WoS8 Europe PMC4
    2016 Arthur, A., Cakouros, D., Cooper, L., Nguyen, T., Isenmann, S., Zannettino, A., . . . Gronthos, S. (2016). Twist-1 enhances bone marrow mesenchymal stromal cell support of hematopoiesis by modulating CXCL12 expression. Stem Cells, 34(2), 504-509.
    DOI Scopus13 WoS13 Europe PMC12
    2016 Nguyen, T., Arthur, A., & Gronthos, S. (2016). The role of Eph/ephrin molecules in stromal–hematopoietic interactions. International Journal of Hematology, 103(2), 145-154.
    DOI Scopus14 WoS14 Europe PMC10
    2016 M Nguyen, T., Arthur, A., & Gronthos, S. (2016). Eph/ephrin-mediated mesenchymal stem cell regulation of T-cell activation and function. Journal of Clinical and Cellular Immunology, 7(3), 418-1-418-7.
    DOI
    2016 Nguyen, T., Arthur, A., Paton, S., Hemming, S., Panagopoulos, R., Codrington, J., . . . Gronthos, S. (2016). Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development. Bone, 93, 12-21.
    DOI Scopus11 WoS11 Europe PMC8
    2015 Nguyen, T., Arthur, A., Panagopoulos, R., Paton, S., Hayball, J., Zannettino, A., . . . Gronthos, S. (2015). EphB4 expressing stromal cells exhibit an enhanced capacity for hematopoietic stem cell maintenance. Stem Cells, 33(9), 2838-2849.
    DOI Scopus22 WoS22 Europe PMC18
    2013 Nguyen, T., Arthur, A., Hayball, J., & Gronthos, S. (2013). Ephb and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells and Development, 22(20), 2751-2764.
    DOI Scopus45 WoS45 Europe PMC38
    2013 Arthur, A., Panagopoulos, R., Cooper, L., Menicanin, D., Parkinson, I., Codrington, J., . . . Gronthos, S. (2013). EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair. Journal of Bone and Mineral Research, 28(4), 926-935.
    DOI Scopus35 WoS33 Europe PMC23
    2012 Leong, W., Henshall, T., Arthur, A., Kremer, K., Lewis, M., Helps, S., . . . Koblar, S. (2012). Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms. Stem Cells Translational Medicine, 1(3), 177-187.
    DOI Scopus104 WoS100 Europe PMC81
    2011 Gronthos, S., Arthur, A., Bartold, P., & Shi, S. (2011). A method to isolate and culture expand human dental pulp stem cells. Methods in Molecular Biology, 698, 107-121.
    DOI Scopus77 Europe PMC44
    2011 Arthur, A., Zannettino, A., Panagopoulos, R., Koblar, S., Sims, N., Stylianou, C., . . . Gronthos, S. (2011). EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation. Bone, 48(3), 533-542.
    DOI Scopus69 WoS65 Europe PMC58
    2010 Psaltis, P., Paton, S., See, F., Arthur, A., Martin, S., Itescu, S., . . . Zannettino, A. (2010). Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations. Journal of Cellular Physiology, 223(2), 530-540.
    DOI Scopus111 WoS106 Europe PMC84
    2009 Isenmann, S., Arthur, A., Zannettino, A., Turner, J., Shi, S., Glackin, C., & Gronthos, S. (2009). TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem Cells, 27(10), 2457-2468.
    DOI Scopus150 WoS146 Europe PMC122
    2009 Arthur, A., Shi, S., Zannettino, A., Fujii, N., Gronthos, S., & Koblar, S. (2009). Implanted adult human dental pulp stem cells induce endogenous axon guidance. Stem Cells, 27(9), 2229-2237.
    DOI Scopus109 WoS109 Europe PMC83
    2009 Arthur, A., Koblar, S., Shi, S., & Gronthos, S. (2009). Eph/ephrinB mediate dental pulp stem cell mobilization and function. Journal of Dental Research, 88(9), 829-834.
    DOI Scopus32 WoS32 Europe PMC18
    2009 Arthur, A., Zannettino, A., & Gronthos, S. (2009). The Therapeutic Applications of Multipotential Mesenchymal/Stromal Stem Cells in Skeletal Tissue Repair. Journal of Cellular Physiology, 218(2), 237-245.
    DOI Scopus266 WoS234 Europe PMC166
    2008 Arthur, A., Rychkov, G., Shi, S., Koblar, S., & Gronthos, S. (2008). Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26(7), 1787-1795.
    DOI Scopus414 WoS401 Europe PMC291
    2008 Zannettino, A., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J., & Gronthos, S. (2008). Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. Journal of Cellular Physiology, 214(2), 413-421.
    DOI Scopus441 WoS396 Europe PMC308
    2007 Arthur, A., Shi, S., Sun, T., Bartold, P., Koblar, S., & Gronthos, S. (2007). EphB/ephrin-B interaction mediates adult stem cell attachment spreading and migration: Implications for dental tissue repair. Stem Cells, 25(1), 156-164.
    DOI Scopus53 WoS55 Europe PMC35
  • Book Chapters

    Year Citation
    2017 Arthur, A., Shi, S., & Gronthos, S. (2017). Dental Pulp Stem Cells: What’s New?. In M. Tatullo (Ed.), MSCs and Innovative Biomaterials in Dentistry (pp. 1-20). Springer.
    DOI
    2014 Arthur, A., Shi, S., & Gronthos, S. (2014). Dental Pulp Stem Cells. In A. Vishwakarma, P. Sharpe, S. Shi, & M. Ramalingam (Eds.), Stem Cell Biology and Tissue Engineering in Dental Sciences (pp. 279-289). United Kingdom: Elsevier Science Publishing Co Inc.
    DOI Scopus3
    2013 Arthur, A., Zannettino, A., & Gronthos, S. (2013). The multipotential of Mesenchymal / Stromal Stem Cells in Skeletal Tissue Repair.. In R. Rajendram, V. Preedy, & V. Patel (Eds.), Stem Cells and Bone Tissue (pp. 82-102).
    DOI Scopus3
  • Conference Papers

    Year Citation
    2019 Arthur, A., Paton, S., Gronthos, S., & Zannettino, A. (2019). The Loss of ephrinB1 in Osteoprogenitors Delays Fracture Repair. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 34 (pp. 326). Orlando, FL: WILEY.
    2018 Nguyen, T. M., Arthur, A., & Gronthos, S. (2018). EPHA FORWARD SIGNALLINGS ENHANCE HUMAN HAEMATOPOIETIC PROGENITOR CELL MIGRATION AND ADHESION VIA RAC1 ACTIVATION. In JOURNAL OF GENE MEDICINE Vol. 20 (pp. 1 page). Univ Technol Sydney, Sydney, AUSTRALIA: WILEY.
    2016 Nguyen, T., Arthur, A., Purton, L., Hayball, J., Zannettino, A., Paton, S., . . . Gronthos, S. (2016). EphB4 enhances bone marrow stromal stem cell-mediated support of haematopoiesis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 30). British Soc Haematol, Glasgow, SCOTLAND: WILEY-BLACKWELL.
    2016 Nguyen, T., Arthur, A., Paton, S., Purton, L., & Gronthos, S. (2016). EphrinB1 expressing stromal cells exhibit an enhanced capacity for haematopoietic stem cell maintenance. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 30). British Soc Haematol, Glasgow, SCOTLAND: WILEY-BLACKWELL.
    2011 Arthur, A., Panagopoulos, R., Cooper, L., Zannettino, A., Koblar, S., Sims, N., . . . Gronthos, S. (2011). THE ROLE OF EPHB/EPHRINB MOLECULES IN FRACTURE REPAIR. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S523). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
    2009 Arthur, A., Stylianou, C., Koblar, S. A., Matsuo, K., & Gronthos, S. (2009). EphB/ephrin-B interactions assist in MSC niche maintenance and contribute to bone remodelling following injury. In BONE Vol. 44 (pp. S142-S143). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
    DOI
    2009 Gronthos, S., Isenmann, S., Arthur, A., Zannettino, A. C. W., Shi, S., & Glackin, C. A. (2009). The role of Twist-1 and-2 in the maintenance of mesenchymal stromal/stem cells. In BONE Vol. 44 (pp. S146). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
    DOI
    2007 Arthur, A., Koblar, S., & Gronthos, S. (2007). The role of EphB/ephrin-B interactions in cell attachment and spreading of mesenchymal precursors derived from human bone marrow and dental pulp tissues. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S370-S371). Honolulu, HI: AMER SOC BONE & MINERAL RES.
  • Conference Items

    Year Citation
    2019 Kutyna, M. M., Wee, A., Paton, S., Cakouros, D., Arthur, A., Chhetri, R., . . . Hiwase, D. K. (2019). Aberrant Bone Marrow Microenvironment in Therapy Related Myeloid Neoplasm (t-MN). Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
    DOI
    2013 Thao, N., Gronthos, S., Arthur, A., & Hayball, J. (2013). Ephb and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Poster session presented at the meeting of Abstracts of the Ephb and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells, as published in Experimental Hematology. Vienna, AUSTRIA: Elsevier.
    DOI

Australian Dental Research Foundation (ARDF) project grant. A pilot study to utilise single cell RNA sequencing (scRNA-seq) to define the bone remodelling microenvironment human periodontitis gingival and bone tissues. ($13,500) 2020. Chief Investigators: Melissa Cantley, Nicholas Quirk, Agnes Arthur, Sushil Kaur, Kent Algate, James Breen.

University of Adelaide, Adelaide Medical Research Committee Small Equipment Award ($1,909) 2019. Chief Investigators: Agnes Arthur and Melissa Cantley.  

University of Adelaide, School of Medicine Equipment Grant. ($23,840) 2019. Chief Investigators: Melissa Cantley and Agnes Arthur 

University of Adelaide, School of Medicine Research Travel Awards ($3000) 2019. Attendance of the ASBMR Conference held in Orlando, Florida, USA

ASBMR Family Care Travel Grant ($400 USD) 2019. Attendance of the ASBMR Conference held in Orlando, Florida, USA

Australian Dental Research Fund #381-2018 ($4,480) 2019. Phenotyping the craniofacial and dental features in a murine model of craniofrontonasal dysplasia (CFND). Chief investigators: Samuel Bereza, Sarbin Ranjitkar, Robin Chi-Weng Yong, Agnes Arthur, Peter Anderson.

International Federation of Musculoskeletal Research Societies (IFMRS) fellowship grant. ($25000 USD) 2018-2019. Note 1 of 2 international fellowships given annually. Principal Investigator: Agnes Arthur.

University of Adelaide, School of Medicine Research Travel Awards ($2870) - Attendance of the ANZBMS Conference held in Queenstown, New Zealand

The Australian Society for Stem Cell Research / National Stem Cell Foundation of Australia travel award ($840) – Attendance of the ISSCR Conference held in Melbourne, Australia

University of Adelaide, School of Medicine Research Travel Awards 2017 ($1000) - Attendance of the ANZBMS conference 2017.

University of Adelaide, School of Medicine Equipment Grant 2016 ($5,040). Chief Investigators: Agnes Arthur, Andrew Zannettino, Stan Gronthos.

University of Adelaide, School of Medicine Research Travel Awards 2016 ($1000) - Attendance of the ANZBMS conference 2016.

Australian Dental Research Fund #44-2014 ($11,363) 2015. The role of EphB/ephrinB activation in allogeneic Dental Pulp Stem Cell mediated dental tissue regeneration following tooth injury. Chief investigators: Stan Gronthos, Agnes Arthur.

National Health & Medical Research Council, Project Grant # APP1083704 (AUD$548,347) 2015-2017. Title: The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis. Chief investigators: Stan Gronthos, Agnes Arthur and Andrew Zannettino. 

RAH Research Fund - Mary Overton Early Career Fellowship #7730 ($250,803) 2013-2016. Principal Investigator: Agnes Arthur.

International Osteoporosis Foundation (IOF), Young Investigator Award ($500) 2011

Travel award funded by the ANZBMS 2009

Robinson Institute, University of Adelaide, Publication Award ($1,000) 2009

Robinson Institute, University of Adelaide, Young Investigator Award ($10,000) 2009-2010. Chief Investigator: Agnes Arthur.

Catholic Archdiocese of Sydney, Adult Stem Cell Research Award ($100,000) 2007-2008. Chief Investigators: Stan Gronthos, Simon Koblar and Agnes Arthur

Principles of Human Health and Disease

Dental Science and Practice I Part I and II

Human Biology IOH Part II

Scientific Basis of Medicine I

Scientific Basis of Medicine II 

Scientific Basis of Medicine III 

Investigative Cell Biology

Medical Science Undergraduate Research Placement 

BHMS Honours Program

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Investigating the Role of Eph/ephrin Molecules in Cross-talk Between Bone and Neural Tissue During Development and Skeletal Tissue Repair Master of Philosophy (Medical Science) Master Full Time Miss Nethmi Abeynayake
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2019 - 2019 Co-Supervisor Investigating the role of ephrinB1/EphB2 downstream signalling in mediating osteoclastogenic/osteogenic interactions University of Adelaide Adelaide Medical School Honours Full Time Kellie Wise
    2018 - ongoing Co-Supervisor Craniofacial phenotyping of EFNB1 null mice. University of Adelaide Dentistry Honours Part Time Samuel Bereza
    2017 - 2017 Co-Supervisor Investigating the Role of ephrinB1 During Skeletal Repair Following Fracture University of Adelaide Adelaide Medical School Honours Full Time Daniel Reed
    2015 - 2015 Co-Supervisor EphB2/ephrinB1 Interactions Mediate Osteoblast/Osteoclast Communication Via Gap Junction Proteins University of Adelaide School of Medical Sciences Honours Full Time Ana Klisuric
  • Position: Research Group Leader - (MCC)
  • Phone: 81284695
  • Email: agnes.arthur@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI, floor 5 South
  • Org Unit: Medical Sciences

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