Dr Maria Gancheva

ARC Grant-Funded Postdoctoral Research Fellow

School of Biological Sciences

College of Science

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Maria is an ARC Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR) post-doctoral fellow and researcher in Associate Professor Danny Wilson's research laboratory on malaria and toxoplasma biology, at the University of Adelaide (School of Biological Sciences). Working closely with industry partner Neoculi Pty Ltd, she leads the drug development studies for treatment of parasitic diseases relevant to human and livestock health. Maria’s research is focused on developing therapeutics with novel mechanisms of action against Plasmodium spp. and Toxoplasma gondii parasites. Malaria, caused by mosquito-transmitted Plasmodium spp. parasites, results in over 200 million cases and over 600,000 deaths each year, with children under the age of five years most at risk. The related food and water-borne zoonotic parasite Toxoplasma gondii, estimated to chronically infect more than a third of the world’s population, poses serious health risks during pregnancy and to immunocompromised individuals. It also has a large economic impact on the livestock industry, costing Australia millions of dollars each year. Parasite resistance to anti-malarial drugs is spreading and the limited efficacy of toxoplasma drugs highlight the urgent need to develop new safe and effective drugs.Maria graduated from The University of Adelaide with a Bachelor of Science (Biomedical Science) degree, majoring in Biochemistry and Microbiology/Immunology, and an Honours degree in Health Sciences (First Class Honours), followed by a PhD in Medicine, within the Stroke Research Programme. Her PhD research focussed on the neurogenic potential of human dental pulp stem cells; potential candidates for cell-based therapies for treatment of neurological diseases, such as stroke. Her dissertation examined the ability to reprogram human dental pulp stem cells along the neural lineage using specific transcription factors and culture conditions, to enhance their neurogenic capacity, including their ability to replace lost neural cells.

Date Position Institution name
2020 - ongoing Academic Researcher The University of Adelaide

Date Type Title Institution Name Country Amount
2020 Award Florey Postgraduate Research Conference Peter Couche Foundation Prize The University of Adelaide Australia -
2020 Award Boehringer Ingelheim Fonds Travel Grant Boehringer Ingelheim Fonds Germany -
2019 Award South Australian Health and Medical Research Institute Annual Scientific Meeting Poster Session PhD Researcher Prize South Australian Health and Medical Research Institute Australia -
2016 Scholarship Australian Government Research Training Program Scholarship Australian Government Australia -
2014 Scholarship Australian Neurology Research Summer Scholarship The Hospital Research Foundation Australia -
2014 Achievement Faculty of Sciences Outstanding Academic Achievement Award The University of Adelaide Australia -
2013 Achievement Faculty of Sciences Outstanding Academic Achievement Award The University of Adelaide Australia -
2012 Achievement Faculty of Sciences Outstanding Academic Achievement Award The University of Adelaide Australia -
2012 Award The University of Adelaide Principals’ Scholarship Award The University of Adelaide Australia -

Language Competency
Bulgarian Can read, write, speak and understand spoken
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2016 - 2021 University of Adelaide, Adelaide Australia PhD in Medicine
2015 - 2015 University of Adelaide, Adelaide Australia Bachelor of Health Sciences Honours
2012 - 2014 University of Adelaide, Adelaide Australia Bachelor of Science (Biomedical Science)

Year Citation
2025 Awalt, J. K., Ooi, Z. K., Ashton, T. D., Mansouri, M., Calic, P. P. S., Zhou, Q., . . . Sleebs, B. E. (2025). Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4. Journal of Medicinal Chemistry, 68(8), 8933-8966.
DOI Scopus2 WoS2 Europe PMC1
2025 Mao, E. Y., Page, S. W., Sleebs, B. E., Gancheva, M. R., & Wilson, D. W. (2025). A review of natural products as a source of next-generation drugs against apicomplexan parasites. npj Antimicrobials and Resistance, 3(1), 51-1-51-15.
DOI WoS2
2025 Mao, E. Y., Nguyen, W., Jana, G. P., Maity, B. C., Pazicky, S., Giannangelo, C., . . . Wilson, D. W. (2025). Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites. Antimicrobial Agents and Chemotherapy, 69(9), e0178324-1-e0178324-27.
DOI
2025 Gancheva, M. R., Mao, E. Y., Romeo, O., Vuong, D., O’Handley, R., Page, S. W., . . . Wilson, D. W. (2025). Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites. International Journal for Parasitology: Drugs and Drug Resistance, 29, 100606-1-100606-14.
DOI
2024 Gancheva, M. R., Kremer, K., Breen, J., Arthur, A., Hamilton-Bruce, A., Thomas, P., . . . Koblar, S. (2024). Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells. Stem Cell Reviews and Reports, 20(3), 797-815.
DOI Scopus5 WoS3 Europe PMC3
2024 Ashton, T. D., Calic, P. P. S., Dans, M. G., Ooi, Z. K., Zhou, Q., Palandri, J., . . . Sleebs, B. E. (2024). Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. Journal of Medicinal Chemistry, 67(16), 14493-14523.
DOI Scopus5 WoS5 Europe PMC4
2024 Ashton, T. D., Calic, P. P. S., Dans, M. G., Ooi, Z. K., Zhou, Q., Loi, K., . . . Sleebs, B. E. (2024). Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4. ChemMedChem: chemistry enabling drug discovery, 19(24), e202400549-1-e202400549-16.
DOI Scopus2 WoS2 Europe PMC3
2023 Dans, M. G., Piirainen, H., Nguyen, W., Khurana, S., Mehra, S., Razook, Z., . . . Gilson, P. R. (2023). Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics. PLoS Biology, 21(4), e3002066-1-e3002066-34.
DOI Scopus9 WoS12 Europe PMC14
2022 Burns, A. L., Sleebs, B. E., Gancheva, M., McLean, K. T., Siddiqui, G., Venter, H., . . . Wilson, D. W. (2022). Targeting malaria parasites with novel derivatives of azithromycin. Frontiers in Cellular and Infection Microbiology, 12(article no. 1063407), 1-10.
DOI Scopus9 WoS8 Europe PMC7
2021 Nguyen, W., Dans, M. G., Ngo, A., Gancheva, M. R., Romeo, O., Duffy, S., . . . Sleebs, B. E. (2021). Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion. European Journal of Medicinal Chemistry, 214, 113253-1-113253-27.
DOI Scopus18 WoS18 Europe PMC10
2021 Bailey, B. L., Nguyen, W., Ngo, A., Goodman, C. D., Gancheva, M. R., Favuzza, P., . . . Sleebs, B. E. (2021). Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity. Bioorganic Chemistry, 115, 105244-1-105244-23.
DOI Scopus17 WoS17 Europe PMC15
2021 Ashton, T. D., Ngo, A., Favuzza, P., Bullen, H. E., Gancheva, M. R., Romeo, O., . . . Sleebs, B. E. (2021). Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity. Bioorganic Chemistry, 117, 105359-1-105359-28.
DOI Scopus18 WoS18 Europe PMC6
2019 Gancheva, M. R., Kremer, K. L., Gronthos, S., & Koblar, S. A. (2019). Using dental pulp stem cells for stroke therapy. Frontiers in Neurology, 10(APR), 422-1-422-17.
DOI Scopus28 WoS27 Europe PMC25

2023, The University of Adelaide, School of Biological Sciences, Early and Mid-Career Researchers’ Association, Small Research Grant, $3000



2019, The Hospital Research Foundation, Project Grant, $22,500

2023, The University of Adelaide, Principles and Practices of Research (Advanced) II: academic mentor.

2002, The University of Adelaide, PAEDIATS3000: guest lecturer.

2018, The University of Adelaide, HLTH SC 3010 A Research Placement (Neuroscience): workshop demonstrator/tutor and assessor.

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Defining how an abundant malaria merozoite surface protein shelters nearby vaccine candidates from protective antibodies Master of Philosophy Master Full Time Miss Kaitlin Renee Turland
2025 Co-Supervisor Optimising lead drug delivery and potency for treatment of apicomplexan parasite infection Doctor of Philosophy Doctorate Full Time Mr Igor Blatov
2025 Co-Supervisor Characterisation of Cross-Species Function for Malaria Merozoite Proteins 4 and 5 Doctor of Philosophy Doctorate Full Time Mr Jarryd Blake Tiu
2025 Co-Supervisor Characterisation of Cross-Species Function for Malaria Merozoite Proteins 4 and 5 Doctor of Philosophy Doctorate Full Time Mr Jarryd Blake Tiu
2025 Co-Supervisor Optimising lead drug delivery and potency for treatment of apicomplexan parasite infection Doctor of Philosophy Doctorate Full Time Mr Igor Blatov
2025 Co-Supervisor Defining how an abundant malaria merozoite surface protein shelters nearby vaccine candidates from protective antibodies Master of Philosophy Master Full Time Miss Kaitlin Renee Turland
2024 Co-Supervisor Characterisation of novel drugs with therapeutic potential against the pathogenic parasites that cause malaria and toxoplasmosis Doctor of Philosophy Doctorate Full Time Miss Emma Yuxin Mao
2024 Co-Supervisor Characterisation of novel drugs with therapeutic potential against the pathogenic parasites that cause malaria and toxoplasmosis Doctor of Philosophy Doctorate Full Time Miss Emma Yuxin Mao

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2018 - 2018 Co-Supervisor Neuroscience Research Placement The University of Adelaide HLTH SC 3010 A and B Research Placement (Neuroscience Major) Other - Emily Squires and Miriam Dodd

Date Role Committee Institution Country
2024 - ongoing Secretary School of Biological Sciences Early- to Mid-Career Researchers Association The University of Adelaide Australia
2018 - 2019 Member Connectome Project Adelaide The University of Adelaide Australia

Date Role Membership Country
2023 - 2023 Member Australian Society for Parasitology Australia
2019 - 2020 Member Australasian Neuroscience Society (ANS) Australia
2018 - ongoing Member International Society for Stem Cell Research (ISSCR) -
2015 - 2017 Member Australian Society for Medical Research (ASMR) Australia
2012 - ongoing Member Golden Key International Honour Society Australia

Date Institution Department Organisation Type Country
2016 - 2016 World Stroke Organisation - - -

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