Dennis Lau

Dennis Lau
Adelaide Medical School
Faculty of Health and Medical Sciences

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Dennis Lau

Dr Lau is an opinion leader in heart rhythm disorders internationally. His research work has provided novel insights regarding catheter ablation of AF from mapping studies in both animal models and human subjects. His work has enhanced the knowledge in the field on atrial remodelling due to various risk factors. Importantly, he has been instrumental in translating these basic studies with active involvement in clinical trials at Centre for Heart Rhythm Disorders examining risk factor management in AF patients. Recent publications from this work are being incorporated into international practice guidelines. Dr Lau is one of few researchers who combine preclinical studies with clinical research in the field of heart rhythm disorders in Australia.

He is actively involved in peer review as invited reviewer for several international scientific journals including Circulation – Arrhythmia and Electrophysiology, Heart Rhythm and Heart. He is an editorial board member for 2 international journals: PeerJ & Journal of Arrhythmia. He has been a co-supervisor for doctoral candidates (5 successfully completed, 8 ongoing).

Appointments

Date Position Institution name
2015 Research Fellow University of Adelaide
2013 Cardiologist Royal Adelaide Hospital

Language Competencies

Language Competency
English Can

Education

Date Institution name Country Title
University of Adelaide Australia PhD
The Royal Australasian College of Physicians Australia FRACP
University of Melbourne Australia MBBS

Keywords

Cardiology

Journals

Date Citation
2017 Spronk,H, De Jong,A, Verheule,S, De Boer,H, Maass,A, Lau,D, Rienstra,M, Van Hunnik,A, Kuiper,M, Lumeij,S et al, 2017, Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation, European Heart Journal, 38, 1, 38-50 10.1093/eurheartj/ehw119
2017 Middeldorp,M, Mahajan,R, Elliott,A, Pathak,R, Twomey,D, Wilson,L, Stolcman,S, Munawar,D, Kumar,S, Lau,D et al, 2017, Premature Trigger of ERI in Medtronic EnRhythm Devices, PACE - Pacing and Clinical Electrophysiology, - 10.1111/pace.13073
2017 Kuklik,P, Zeemering,S, Van Hunnik,A, Maesen,B, Pison,L, Lau,D, Maessen,J, Podziemski,P, Meyer,C, Schaffer,B et al, 2017, Identification of rotors during human atrial fibrillation using contact mapping and phase singularity detection: Technical considerations, IEEE Transactions on Biomedical Engineering, 64, 2, 310-318 10.1109/TBME.2016.2554660
2017 Thanigaimani,S, Brooks,A, Kuklik,P, Twomey,D, Franklin,S, Noschka,E, Chapman,D, Pathak,R, Mahajan,R, Sanders,P et al, 2017, Spatiotemporal characteristics of atrial fibrillation electrograms: A novel marker for arrhythmia stability and termination, Journal of Arrhythmia, 33, 1, 40-48 10.1016/j.joa.2016.05.009
2017 Thanigaimani,S, Lau,D, Agbaedeng,T, Elliott,A, Mahajan,R, Sanders,P, 2017, Molecular mechanisms of atrial fibrosis: implications for the clinic, Expert review of cardiovascular therapy, 15, 4, 247-256 10.1080/14779072.2017.1299005
2017 Mahajan,R, Lau,D, 2017, Towards improved understanding of atrial fibrillation in South Asians, Trends in Cardiovascular Medicine, 27, 4, - 10.1016/j.tcm.2016.12.006
2016 Sanders,P, Lau,D, 2016, Mortality Paradox in Obesity and Atrial Fibrillation: True Clinical Phenomenon or Red Herring in Atrial Fibrillation Care?, JACC: Clinical Electrophysiology, 2, 3, 364-366 10.1016/j.jacep.2016.02.001
2016 Gallagher,C, Hendriks,J, Mahajan,R, Middeldorp,M, Elliott,A, Pathak,R, Sanders,P, Lau,D, 2016, Lifestyle management to prevent and treat atrial fibrillation, Expert Review of Cardiovascular Therapy, 14, 7, 799-809 10.1080/14779072.2016.1179581
2016 Lau,D, Middeldorp,M, Sanders,P, 2016, Obesity paradox in atrial fibrillation: A distracting reality or fictitious finding?, European Heart Journal, 37, 38, 2879-2881 10.1093/eurheartj/ehw261
2016 Elliott,A, Pathak,R, Mahajan,R, Lau,D, Sanders,P, 2016, Reply Benefit of Exercise in Atrial Fibrillation: Diastolic Function Matters!, Journal of the American College of Cardiology, 67, 10, 1258-1259 10.1016/j.jacc.2015.12.041
2016 Neo,M, Morris,D, Kuklik,P, Lau,D, Dimitri,H, Lim,W, Sanders,P, Saint,D, 2016, Simultaneous conduction mapping and intracellular membrane potential recording in isolated atria, Canadian Journal of Physiology and Pharmacology, 94, 5, 563-569 10.1139/cjpp-2015-0194
2016 Wong,G, Lau,D, Middeldorp,M, Harrington,J, Stolcman,S, Wilson,L, Twomey,D, Kumar,S, Munawar,D, Khokhar,K et al, 2016, Feasibility and safety of Reveal LINQ insertion in a sterile procedure room versus electrophysiology laboratory, International Journal of Cardiology, 223, 13-17 10.1016/j.ijcard.2016.08.113
2016 Lim,H, Denis,A, Middeldorp,M, Lau,D, Mahajan,R, Derval,N, Albenque,J, Boveda,S, Zellerhoff,S, Yamashita,S et al, 2016, Persistent atrial fibrillation from the onset: a specific subgroup of patients with biatrial substrate involvement and poorer clinical outcome, JACC: Clinical Electrophysiology, 2, 2, 129-139 10.1016/j.jacep.2015.12.014
2016 Pathak,R, Evans,M, Middeldorp,M, Mahajan,R, Mehta,A, Meredith,M, Twomey,D, Wong,C, Hendriks,J, Abhayaratna,W et al, 2016, Cost-Effectiveness and Clinical Effectiveness of the Risk Factor Management Clinic in Atrial Fibrillation. The CENT Study, JACC: Clinical Electrophysiology, - 10.1016/j.jacep.2016.12.015
2016 Lim,W, Baumert,M, Neo,M, Kuklik,P, Ganesan,A, Lau,D, Tsoutsman,T, Semsarian,C, Sanders,P, Saint,D et al, 2016, Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy, Clinical and Experimental Pharmacology and Physiology, 43, 1, 95-101 10.1111/1440-1681.12498
2016 Van Hunnik,A, Lau,D, Zeemering,S, Kuiper,M, Verheule,S, Schotten,U, 2016, Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness, Heart Rhythm, 13, 4, 964-972 10.1016/j.hrthm.2015.12.009
2016 Wong,C, Sun,M, Odutayo,A, Emdin,C, Mahajan,R, Lau,D, Pathak,R, Wong,D, Selvanayagam,J, Sanders,P et al, 2016, Associations of epicardial, abdominal, and overall adiposity with atrial fibrillation, Circulation: Arrhythmia and Electrophysiology, 9, 12, 1-29 10.1161/CIRCEP.116.004378
2016 Lau,D, Mahajan,R, Lee,G, Kalman,J, Sanders,P, 2016, Towards Improved Care of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncope Patients: A Call to Action in Australia, Heart Lung and Circulation, 25, 1, 8-11 10.1016/j.hlc.2015.10.001
2016 Pathak,R, Elliott,A, Mahajan,R, Lau,D, Sanders,P, 2016, Reply atrial fibrillation is an obesity-related outcome, requiring a body composition-neutral assessment of cardiorespiratory fitness, Journal of the American College of Cardiology, 67, 3, 349-350 10.1016/j.jacc.2015.10.069
2016 Elliott,A, Mahajan,R, Pathak,R, Lau,D, Sanders,P, 2016, Exercise training and Atrial fibrillation: Further evidence for the importance of lifestyle change, Circulation, 133, 5, 457-459 10.1161/CIRCULATIONAHA.115.020800
2016 Elliott,A, Mahajan,R, Lau,D, Sanders,P, 2016, Atrial fibrillation in endurance athletes: from mechanism to management, Cardiology Clinics, 34, 4, 567-578 10.1016/j.ccl.2016.06.006
2016 Lau,D, Schotten,U, Mahajan,R, Antic,N, Hatem,S, Pathak,R, Hendriks,J, Kalman,J, Sanders,P, 2016, Novel mechanisms in the pathogenesis of atrial fibrillation: Practical applications, European Heart Journal, 37, 20, 1573-1581 10.1093/eurheartj/ehv375
2015 Lau,D, Maesen,B, Zeemering,S, Kuklik,P, Hunnik,A, Lankveld,T, Bidar,E, Verheule,S, Nijs,J, Maessen,J et al, 2015, Indices of bipolar complex fractionated atrial electrograms correlate poorly with each other and atrial fibrillation substrate complexity, Heart Rhythm, 12, 7, 1415-1423 10.1016/j.hrthm.2015.03.017
2015 Boriani,G, Savelieva,I, Dan,G, Deharo,J, Ferro,C, Israel,C, Lane,D, La Manna,G, Morton,J, Mitjans,A et al, 2015, Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: Clinical significance and implications for decision making- A position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society, Europace, 17, 8, 1169-1196 10.1093/europace/euv202
2015 Pathak,R, Mehta,A, Lau,D, Sanders,P, 2015, Reply: Going Over LEGACY With a Pinch of Salt, Journal of the American College of Cardiology, 66, 17, 1946- 10.1016/j.jacc.2015.07.077
2015 Pathak,R, Middeldorp,M, Meredith,M, Mehta,A, Mahajan,R, Wong,C, Twomey,D, Elliott,A, Kalman,J, Abhayaratna,W et al, 2015, Long-term effect of goal-directed weight management in an atrial fibrillation cohort: a long-term follow-up study (LEGACY), Journal of the American College of Cardiology, 65, 20, 2159-2169 10.1016/j.jacc.2015.03.002
2015 Kuklik,P, Lau,D, Ganesan,A, Brooks,A, Sanders,P, 2015, High-density mapping of atrial fibrillation in a chronic substrate: evidence for distinct modes of repetitive wavefront propagation, International Journal of Cardiology, 199, 407-414 10.1016/j.ijcard.2015.07.057
2015 Ganesan,A, Nandal,S, Lüker,J, Pathak,R, Mahajan,R, Twomey,D, Lau,D, Sanders,P, 2015, Catheter ablation of atrial fibrillation in patients with concomitant left ventricular impairment: a systematic review of efficacy and effect on ejection fraction, Heart Lung and Circulation, 24, 3, 270-280 10.1016/j.hlc.2014.09.012
2015 Wong,G, Lau,D, Baillie,T, Middeldorp,M, Steele,P, Sanders,P, 2015, Novel use of sildenafil in the management of pulmonary hypertension due to post-catheter ablation 'stiff left atrial syndrome', International Journal of Cardiology, 181, 55-56 10.1016/j.ijcard.2014.12.012
2015 Sheldon,R, Grubb,B, Olshansky,B, Shen,W, Calkins,H, Brignole,M, Raj,S, Krahn,A, Morillo,C, Stewart,J et al, 2015, 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope, Heart Rhythm, 12, 6, e41-e63 10.1016/j.hrthm.2015.03.029
2015 Pathak,R, Mahajan,R, Lau,D, Sanders,P, 2015, Sleep apnea and cardiac arrhythmia: a timely wake-up call!, Sleep, 38, 7, 1005-1006 10.5665/sleep.4796
2015 Wong,C, Lee,S, Gan,S, Mahajan,R, Rangnekar,G, Pathak,R, Twomey,D, Schultz,C, Ganesan,A, Brooks,A et al, 2015, Underuse and overuse of anticoagulation for atrial fibrillation: a study in Indigenous and non-Indigenous Australians, International Journal of Cardiology, 191, 20-24 10.1016/j.ijcard.2015.03.064
2015 Pathak,R, Mahajan,R, Lau,D, Sanders,P, 2015, The implications of obesity for cardiac arrhythmia mechanisms and management, Canadian Journal of Cardiology, 31, 2, 203-210 10.1016/j.cjca.2014.10.027
2015 Wong,C, Sullivan,T, Sun,M, Mahajan,R, Pathak,R, Middeldorp,M, Twomey,D, Ganesan,A, Rangnekar,G, Roberts-Thomson,K et al, 2015, Obesity and the risk of incident, post-operative, and post-ablation atrial fibrillation: a meta-analysis of 626,603 individuals in 51 studies, JACC: Clinical Electrophysiology, 1, 3, 139-152 10.1016/j.jacep.2015.04.004
2015 Mahajan,R, Lau,D, Brooks,A, Shipp,N, Manavis,J, Wood,J, Finnie,J, Samuel,C, Royce,S, Twomey,D et al, 2015, Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity, Journal of the American College of Cardiology, 66, 1, 1-11 10.1016/j.jacc.2015.04.058
2015 Mahajan,R, Lau,D, Sanders,P, 2015, Impact of obesity on cardiac metabolism, fibrosis, and function, Trends in Cardiovascular Medicine, 25, 2, 119-126 10.1016/j.tcm.2014.09.005
2015 Pathak,R, Mahajan,R, Lau,D, Sanders,P, 2015, Reply: BMI reduction decreases AF recurrence rate in a mediterranean cohort, Journal of the American College of Cardiology, 66, 20, 2265-2266 10.1016/j.jacc.2015.08.885
2015 Lim,HS, Willoughby,SR, Schultz,C, Alasady,M, Rangnekar,G, Dang,J, Gan,C, Lau,DH, Roberts-Thomson,KC, Young,GD et al, 2015, Thrombogenic risk in patients with atrial fibrillation, JACC: Clinical Electrophysiology, 1, 3, 210-217 10.1016/j.jacep.2015.03.011
2015 Lau,D, Volders,P, Kohl,P, Prinzen,F, Zaza,A, Kaab,S, Oto,A, Schotten,U, 2015, Opportunities and challenges of current electrophysiology research: a plea to establish ‘translational electrophysiology’ curricula, Europace, 17, 5, 825-833 10.1093/europace/euu301
2015 Parthiban,N, Esterman,A, Mahajan,R, Twomey,D, Pathak,R, Lau,D, Roberts-Thomson,K, Young,G, Sanders,P, Ganesan,A et al, 2015, Remote monitoring of implantable cardioverter-defibrillators: a systematic review and meta-analysis of clinical outcomes, Journal of the American College of Cardiology, 65, 24, 2591-2600 10.1016/j.jacc.2015.04.029
2015 Pathak,R, Elliott,A, Middeldorp,M, Meredith,M, Mehta,A, Mahajan,R, Hendriks,J, Twomey,D, Kalman,J, Abhayaratna,W et al, 2015, Impact of CARDIOrespiratory FITness on arrhythmia recurrence in obese individuals with atrial fibrillation: the CARDIO-FIT Study, Journal of the American College of Cardiology, 66, 9, 985-996 10.1016/j.jacc.2015.06.488
2014 Mahajan,R, Lau,D, Sanders,P, 2014, Biomarkers and atrial fibrillation: is it prime time yet?, Heart, 100, 15, 1151-1152 10.1136/heartjnl-2014-306008
2014 Wong,C, Lau,D, Sanders,P, 2014, Atrial fibrillation epidemic and hospitalizations: how to turn the rising tide?, Circulation, 129, 23, 2361-2363 10.1161/CIRCULATIONAHA.114.010073
2014 Pathak,R, Middeldorp,M, Lau,D, Mehta,A, Mahajan,R, Twomey,D, Alasady,M, Hanley,L, Antic,N, McEvoy,R et al, 2014, Aggressive risk factor reduction study for atrial fibrillation and implications for the outcome of ablation: the ARREST-AF Cohort Study, Journal of the American College of Cardiology, 64, 21, 2222-2231 10.1016/j.jacc.2014.09.028
2014 Lim,H, Willoughby,S, Schultz,C, Chakrabarty,A, Alasady,M, Lau,D, Roberts-Thomson,K, Worthley,M, Young,G, Sanders,P et al, 2014, Successful catheter ablation decreases platelet activation and improves endothelial function in patients with atrial fibrillation, Heart Rhythm, 11, 11, 1912-1918 10.1016/j.hrthm.2014.07.030
2014 Wong,C, Brooks,A, Cheng,Y, Lau,D, Rangnekar,G, Roberts-Thomson,K, Kalman,J, Brown,A, Sanders,P, 2014, Atrial fibrillation in Indigenous and non-Indigenous Australians: a cross-sectional study, BMJ Open, 4, 10, e006242-1-e006242-6 10.1136/bmjopen-2014-006242
2014 Ganesan,A, Kuklik,P, Gharaviri,A, Brooks,A, Chapman,D, Lau,D, Roberts-Thomson,K, Sanders,P, 2014, Origin and characteristics of high Shannon entropy at the pivot of locally stable rotors: insights from computational simulation, PloS one, 9, 11, e110662-1-e110662-9 10.1371/journal.pone.0110662
2014 Lau,D, Kalman,J, Sanders,P, 2014, Management of recent-onset sustained atrial fibrillation: pharmacologic and nonpharmacologic strategies, Clinical Therapeutics, 36, 9, 1151-1159 10.1016/j.clinthera.2014.08.002
2014 Lim,H, Schultz,C, Dang,J, Alasady,M, Lau,D, Brooks,A, Wong,C, Roberts-Thomson,K, Young,G, Worthley,M et al, 2014, Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation, Circulation: Arrhythmia and Electrophysiology, 7, 1, 83-89 10.1161/CIRCEP.113.000876
2013 Lau,D, Zeemering,S, Maesen,B, Kuklik,P, Verheule,S, Schotten,U, 2013, Catheter ablation targeting complex fractionated atrial electrogram in atrial fibrillation, Journal of Atrial Fibrillation, 6, 3, 86-92
2013 Ganesan,A, Shipp,N, Brooks,A, Kuklik,P, Lau,D, Lim,H, Sullivan,T, Roberts-Thomson,K, Sanders,P, 2013, Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis, Journal of the American Heart Association, 2, 2, e004549-1-e004549-14 10.1161/JAHA.112.004549
2013 Pathak,R, Lau,DH, Mahajan,R, Sanders,P, 2013, Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation, Journal of Atrial Fibrillation, 6, 4, 53-64
2013 Ganesan,A, Kuklik,P, Lau,D, Brooks,A, Baumert,M, Lim,W, Thanigaimani,S, Nayyar,S, Mahajan,N, Kalman,J et al, 2013, Bipolar electrogram Shannon entropy at sites of rotational activation: implications for ablation of atrial fibrillation, Circulation. Arrhythmia and Elecrophysiology (online), 6, 1, 48-57 10.1161/CIRCEP.112.976654
2013 Lau,D, Middeldorp,M, Brooks,A, Ganesan,A, Roberts-Thomson,K, Stiles,M, Leong,D, Abed,H, Lim,H, Wong,C et al, 2013, Aortic stiffness in lone atrial fibrillation: A novel risk factor for arrhythmia recurrence, PLoS One, 8, 10, 1-9 10.1371/journal.pone.0076776
2013 Aakriti,G, Perera,T, Ganesan,A, Sullivan,T, Lau,D, Roberts-Thomson,K, Brooks,A, Sanders,P, 2013, Complications of catheter ablation of atrial fibrillation a systematic review, Circulation, Arrhythmia & Electrophysiology (Print), 6, 6, 1082-1088 10.1161/CIRCEP.113.000768
2013 Abed,H, Samuel,C, Lau,D, Kelly,D, Royce,S, Alasady,M, Mahajan,R, Kuklik,P, Zhang,Y, Brooks,A et al, 2013, Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation, Heart Rhythm, 10, 1, 90-100 10.1016/j.hrthm.2012.08.043
2013 Lau,D, Shipp,N, Kelly,D, Thanigaimani,S, Neo,M, Kuklik,P, Lim,H, Zhang,Y, Drury,K, Wong,C et al, 2013, Atrial arrhythmia in ageing spontaneously hypertensive rats: Unraveling the substrate in hypertension and ageing, PLoS One, 8, 8, 1-10 10.1371/journal.pone.0072416
2013 Alasady,M, Shipp,N, Brooks,A, Lim,H, Lau,D, Barlow,D, Kuklik,P, Worthley,M, Roberts-Thomson,K, Saint,D et al, 2013, Myocardial infarction and atrial fibrillation importance of atrial ischemia, Circulation, Arrhythmia & Electrophysiology (Print), 6, 4, 738-745 10.1161/CIRCEP.113.000163
2013 Burch,A, Wong,C, Sullivan,T, Brooks,A, Leong,D, Lau,D, Sun,M, Roberts-Thomson,K, Sanders,P, 2013, Trends in the use of implantable cardioverter defibrillators in Australia: a 10-year nationwide study from 2000-2009, Internal Medicine Journal, 43, 8, 888-895 10.1111/imj.12201
2013 Lim,H, Willoughby,S, Schultz,C, Gan,C, Alasady,M, Lau,D, Leong,D, Brooks,A, Young,G, Kistler,P et al, 2013, Effect of atrial fibrillation on atrial thrombogenesis in humans: Impact of rate and rhythm, Journal of the American College of Cardiology, 61, 8, 852-860 10.1016/j.jacc.2012.11.046
2013 Abed,H, Wittert,G, Leong,D, Shirazi,M, Bahrami,B, Middeldorp,M, Lorimer,M, Lau,D, Antic,N, Brooks,A et al, 2013, Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation a randomized clinical trial, Jama-journal of the American Medical Association, 310, 19, 2050-2060 10.1001/jama.2013.280521
2013 Wong,C, Sun,M, Lau,D, Brooks,A, Sullivan,T, Worthley,M, Roberts-Thomson,K, Sanders,P, 2013, Nationwide trends in the incidence of acute myocardial infarction in Australia, 1993-2010, American Journal of Cardiology, 112, 2, 169-173 10.1016/j.amjcard.2013.03.014
2013 Brooks,A, Wilson,L, Chia,N, Lau,D, Alasady,M, Leong,D, Laborderie,J, Roberts-Thomson,K, Young,G, Kalman,J et al, 2013, Accuracy and clinical outcomes of CT image integration with Carto-Sound compared to electro-anatomical mapping for atrial fibrillation ablation: A randomized controlled study, International Journal of Cardiology, 168, 3, 2774-2782 10.1016/j.ijcard.2013.03.130
2013 Wong,C, Sun,M, Cheng,Y, Dang,J, Barlow,D, Chia,N, Wong,N, Wong,M, Lau,D, Brooks,A et al, 2013, Temporal and comparative outcomes of cardiac electrophysiology abstracts, American Journal of Cardiology, 112, 2, 251-254 10.1016/j.amjcard.2013.03.016
2012 Wong,C, Brooks,A, Lau,D, Leong,D, Sun,M, Sullivan,T, Roberts-Thomson,K, Sanders,P, 2012, Factors associated with the epidemic of hospitalizations due to atrial fibrillation, American Journal of Cardiology, 110, 10, 1496-1499 10.1016/j.amjcard.2012.07.011
2012 Abed,H, Alasady,M, Lau,D, Lim,H, Sanders,P, 2012, Approach to the difficult transseptal: Diathermy facilitated left atrial access, Heart, Lung & Circulation (Print Edition), 21, 2, 108-112 10.1016/j.hlc.2011.07.010
2012 Zeemering,S, Maesen,B, Nijs,J, Lau,D, Granier,M, Verheule,S, Schotten,U, 2012, Automated quantification of atrial fibrillation complexity by probabilistic electrogram analysis and fibrillation wave reconstruction, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, 6357-6360 10.1109/EMBC.2012.6347448
2012 Ganesan,A, Brooks,A, Roberts-Thomson,K, Lau,D, Kalman,J, Sanders,P, 2012, Role of AV nodal ablation in cardiac synchronization in patients with coexistent atrial fibrillation and heart failure: a systematic review, Journal of the American College of Cardiology, 59, 8, 719-726 10.1016/j.jacc.2011.10.891
2012 Wilson,L, Brooks,A, Lau,D, Dimitri,H, Sharma,G, Lim,H, Alasady,M, Young,G, Sanders,P, 2012, Real-time CartoSound imaging of the esophagus: a comparison to computed tomography, International Journal of Cardiology, 157, 2, 260-262 10.1016/j.ijcard.2012.03.037
2012 Wong,C, John,B, Brooks,A, Chandy,S, Kuklik,P, Lau,D, Sullivan,T, Roberts-Thomson,K, Sanders,P, 2012, Direction-dependent conduction abnormalities in the chronically stretched atria, Europace, 14, 7, 954-961 10.1093/europace/eur428
2012 Mahajani,R, Brooks,A, Sullivan,T, Lim,H, Alasady,M, Abed,H, Ganesan,A, Nayyar,S, Lau,D, Roberts-Thomson,K et al, 2012, Importance of the underlying substrate in determining thrombus location in atrial fibrillation: implications for left atrial appendage closure, Heart, 98, 15, 1120-1126 10.1136/heartjnl-2012-301799
2012 Derejko,P, Szumowski,L, Sanders,P, Krupa,W, Bodalski,R, Orczykowski,M, Urbanek,P, Zakrzewska,J, Lim,H, Lau,D et al, 2012, Atrial fibrillation in patients with Wolff-Parkinson-White syndrome: Role of pulmonary veins, Journal of Cardiovascular Electrophysiology, 23, 3, 280-286 10.1111/j.1540-8167.2011.02203.x
2012 Lau,D, Maesen,B, Zeemering,S, Verheule,S, Crijns,H, Schotten,U, 2012, Stability of complex fractionated atrial electrograms: A systematic review, Journal of Cardiovascular Electrophysiology, 23, 9, 980-987 10.1111/j.1540-8167.2012.02335.x
2012 Dimitri,H, Ng,M, Brooks,A, Kuklik,P, Stiles,M, Lau,D, Antic,N, Thornton,A, Saint,D, McEvoy,R et al, 2012, Atrial remodeling in obstructive sleep apnea: implications for atrial fibrillation, Heart Rhythm, 9, 3, 321-327 10.1016/j.hrthm.2011.10.017
2011 Roberts-Thomson,K, Lau,D, Sanders,P, 2011, The diagnosis and management of ventricular arrhythmias, Nature Reviews Cardiology, 8, 6, 311-321 10.1038/nrcardio.2011.15
2011 Psaltis,P, Carbone,A, Leong,D, Lau,D, Nelson,A, Kuchel,T, Jantzen,T, Manavis,J, Williams,K, Sanders,P et al, 2011, Assessment of myocardial fibrosis by endoventricular electromechanical mapping in experimental nonischemic cardiomyopathy, International Journal of Cardiovascular Imaging, 27, 1, 25-37 10.1007/s10554-010-9657-5
2011 Lau,D, Psaltis,P, Mackenzie,L, Kelly,D, Carbone,A, Worthington,M, Nelson,A, Zhang,Y, Kuklik,P, Wong,C et al, 2011, Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort, Journal of Cardiovascular Electrophysiology, 22, 2, 175-182 10.1111/j.1540-8167.2010.01851.x
2011 Wong,C, Abed,H, Molaee,P, Nelson,A, Brooks,A, Sharma,G, Leong,D, Lau,D, Middeldorp,M, Roberts-Thomson,K et al, 2011, Pericardial fat is associated with atrial fibrillation severity and ablation outcome, Journal of the American College of Cardiology, 57, 17, 1745-1751 10.1016/j.jacc.2010.11.045
2011 Lau,D, Psaltis,P, Carbone,A, Kelly,D, Mackenzie,L, Worthington,M, Metcalf,R, Kuklik,P, Nelson,A, Zhang,Y et al, 2011, Atrial protective effects of n-3 polyunsaturated fatty acids: A long-term study in ovine chronic heart failure, Heart Rhythm, 8, 4, 575-582 10.1016/j.hrthm.2010.12.009
2011 Lau,D, Roberts-Thomson,K, Sanders,P, 2011, Sinus node revisited, Current Opinion in Cardiology, 26, 1, 55-59 10.1097/HCO.0b013e32834138f4
2011 Mahajan,R, Lim,H, Lau,D, Sanders,P, 2011, Left superior pulmonary vein rhythm masquerading as sinus rhythm, Indian Pacing and Electrophysiology Journal, 11, 1, 20-23
2011 Abed,H, Lau,D, Kelly,D, Nelson,A, Wittert,G, Sanders,P, 2011, Obesity and Atrial Fibrillation: A Chronic Ovine Study, Journal of Arrhythmia, 27, Supplement, YIAB_1-YIAB_1 10.4020/jhrs.27.YIAB_1
2010 Lau,D, Brooks,A, Sanders,P, 2010, AF Termination: the Holy Grail of persistent AF ablation?, Journal of Atrial Fibrillation, 1, 12, 702-704
2010 Brooks,A, Stiles,M, Laborderie,J, Lau,D, Kuklik,P, Shipp,N, Hsu,L, Sanders,P, 2010, Outcomes of long-standing persistent atrial fibrillation ablation: A systematic review, Heart Rhythm, 7, 6, 835-846 10.1016/j.hrthm.2010.01.017
2010 Lau,D, Mackenzie,L, Rajendram,A, Psaltis,P, Kelly,D, Spyropoulos,P, Zhang,Y, Olakkengil,S, Russell,C, Brooks,A et al, 2010, Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model, Blood Pressure, 19, 2, 119-125 10.3109/08037050903576767
2010 Lau,D, Alasady,M, Brooks,A, Sanders,P, 2010, New onset atrial fibrillation and acute coronary syndrome, Expert Review of Cardiovascular Therapy, 8, 7, 941-948 10.1586/erc.10.61
2010 Lau,D, Mackenzie,L, Shipp,N, Kuklik,P, Dimitri,H, Lobb,B, Alasady,M, Lim,H, Kelly,D, Brooks,A et al, 2010, Feasibility of high-density electrophysiological study using multiple-electrode array in isolated small animal atria, Clinical and Experimental Pharmacology and Physiology, 37, 10, 1023-1027 10.1111/j.1440-1681.2010.05435.x
2010 Wong,C, Stiles,M, John,B, Brooks,A, Lau,D, Dimitri,H, Kuklik,P, Shipp,N, Sullivan,T, Sanders,P et al, 2010, Direction-dependent conduction in lone atrial fibrillation, Heart Rhythm, 7, 9, 1192-1199 10.1016/j.hrthm.2010.05.037
2010 Psaltis,P, Carbone,A, Nelson,A, Lau,D, Jantzen,T, Manavis,J, Williams,K, Itescu,S, Sanders,P, Gronthos,S et al, 2010, Reparative effects of allogeneic mesenchymal precursor cells delivered transendocardially in experimental nonischemic cardiomyopathy, JACC: Cardiovascular Interventions, 3, 9, 974-983 10.1016/j.jcin.2010.05.016
2010 Lau,D, Mackenzie,L, Kelly,D, Psaltis,P, Brooks,A, Worthington,M, Rajendram,A, Kelly,D, Zhang,Y, Kuklik,P et al, 2010, Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model, Heart Rhythm, 7, 9, 1282-1290 10.1016/j.hrthm.2010.05.010
2010 Lau,D, Mackenzie,L, Kelly,D, Psaltis,P, Worthington,M, Rajendram,A, Kelly,D, Nelson,A, Zhang,Y, Kuklik,P et al, 2010, Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model, Heart Rhythm, 7, 3, 396-404 10.1016/j.hrthm.2009.11.031
2010 Stiles,M, Wong,C, John,B, Kuklik,P, Brooks,A, Lau,D, Dimitri,H, Wilson,L, Young,G, Sanders,P et al, 2010, Characterization of atrial remodeling studied remote from episodes of typical atrial flutter, American Journal of Cardiology, 106, 4, 528-534 10.1016/j.amjcard.2010.03.069
2009 Nelson,A, Worthley,M, Psaltis,P, Carbone,A, Dundon,B, Duncan,R, Piantadosi,C, Lau,D, Sanders,P, Wittert,G et al, 2009, Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume, Journal of Cardiovascular Magnetic Resonance, 11, 1, 1-8 10.1186/1532-429X-11-15
2009 Lau,D, Huynh,L, Chew,D, Astley,C, Soman,A, Sanders,P, 2009, Prognostic impact of types of atrial fibrillation in acute coronary syndromes, American Journal of Cardiology, 104, 10, 1317-1323 10.1016/j.amjcard.2009.06.055
2009 Wong,C, Wong,M, Wong,N, Sun,M, Brooks,A, Stiles,M, Lau,D, Nelson,A, De Sciscio,P, Shipp,N et al, 2009, Impact of research presentations at the annual scientific sessions of the Heart Rhythm Society, Heart Rhythm, 6, 9, 1345-1348 10.1016/j.hrthm.2009.06.007
2009 Thavapalachandran,S, Leong,D, Stiles,M, John,B, Dimitri,H, Lau,D, Psaltis,P, Brooks,A, Alasady,M, Lim,H et al, 2009, Evidence-based management of heart failure in clinical practice: a review of device-based therapy use, Internal Medicine Journal, 39, 10, 669-675 10.1111/j.1445-5994.2008.01876.x
2009 Sanders,P, Jaïs,P, Young,G, Sacher,F, Rotter,M, Hocini,M, Hsu,L, Stiles,M, John,B, Lau,D et al, 2009, Atrial Mechanical Function after Atrial Fibrillation Ablation, 225-232 10.1002/9781444300185.ch16
2009 Roberts-Thomson,K, John,B, Worthley,S, Brooks,A, Stiles,M, Lau,D, Kuklik,P, Shipp,N, Kalman,J, Sanders,P et al, 2009, Left atrial remodeling in patients with atrial septal defects, Heart Rhythm, 6, 7, 1000-1006 10.1016/j.hrthm.2009.03.050
2009 Stiles,M, John,B, Wong,C, Kuklik,P, Brooks,A, Lau,D, Dimitri,H, Roberts-Thomson,K, Wilson,L, De Sciscio,P et al, 2009, Paroxysmal lone atrial fibrillation is associated with an abnormal atrial substrate, Journal of the American College of Cardiology, 53, 14, 1182-1191 10.1016/j.jacc.2008.11.054
2008 Lau,D, Wilson,L, Stiles,M, Shashidhar,, Dimitri,H, Brooks,A, Young,G, Sanders,P, 2008, Defibrillator reset by radiotherapy, International Journal of Cardiology, 130, 1, E37-E38 10.1016/j.ijcard.2007.06.145
2008 Brooks,A, Wilson,L, Kuklik,P, Stiles,M, John,B, Shashidhar,, Dimitri,H, Lau,D, Roberts-Thomson,R, Wong,C et al, 2008, Image integration using NavX fusion: Initial experience and validation, Heart Rhythm, 5, 4, 526-535 10.1016/j.hrthm.2008.01.008
2008 Stiles,M, Brooks,A, John,B, Shashidar,M, Wilson,L, Kuklik,P, Dimitri,H, Lau,D, Roberts-Thomson,R, Mackenzie,L et al, 2008, The effect of electrogram duration on quantification of complex fractionated atrial electrograms and dominant frequency, Journal of Cardiovascular Electrophysiology, 19, 3, 252-258 10.1111/j.1540-8167.2007.01034.x
2008 Psaltis,P, Carbone,A, Nelson,A, Lau,D, Manavis,J, Finnie,J, Teo,K, Mackenzie,L, Sanders,P, Gronthos,S et al, 2008, An ovine model of toxic, nonischemic cardiomyopathy-assessment by cardiac magnetic resonance imaging, Journal of Cardiac Failure, 14, 9, 785-795 10.1016/j.cardfail.2008.06.449
2008 Stiles,M, Brooks,A, Kuklik,P, John,B, Dimitri,H, Lau,D, Wilson,L, Dhar,S, Roberts-Thomson,R, Mackenzie,L et al, 2008, High-density mapping of atrial fibrillation in humans: Relationship between high-frequency activation and electrogram fractionation, Journal of Cardiovascular Electrophysiology, 19, 12, 1245-1253 10.1111/j.1540-8167.2008.01253.x
2007 Leong,D, Stiles,M, John,B, Lau,D, Young,G, Sanders,P, 2007, Spontaneous degeneration of supraventricular tachycardia to ventricular fibrillation, Journal of Cardiovascular Electrophysiology, 18, 3, 336-337 10.1111/j.1540-8167.2006.00710.x
2007 Stiles,M, Lau,D, Young,G, Sanders,P, 2007, Delayed termination of ventricular tachycardia after cardioversion, Europace, 9, 9, 730-731 10.1093/europace/eum136
2007 Stiles,M, Sanders,P, Disney,P, Brooks,A, John,B, Lau,D, Shashidhar,, Wilson,L, Mackenzie,L, Young,G et al, 2007, Differential effects of intravenous magnesium on atrioventricular node conduction in supraventricular tachycardia, American Journal of Cardiology, 100, 8, 1249-1253 10.1016/j.amjcard.2007.05.051
2007 Lau,D, Stiles,M, Shashidhar,, Young,G, Sanders,P, 2007, Atrial fibrillation and anabolic steroid abuse, International Journal of Cardiology, 117, 2, e86-e87 10.1016/j.ijcard.2006.11.199

Book Chapters

Date Citation
2015 Ganesan,A, Lau,D, Sanders,P, 2015, How to select target sites in electrogram-guided ablationoptions, techniques, and results, pp. 191-205 10.1002/9781118658369.ch14
2014 Sanders,P, Lau,DH, Kalman,JM, 2014, Sinus Node Abnormalities, Elsevier, USA, pp. 691-697 10.1016/B978-1-4557-2856-5.00072-8

Conference Papers

Date Citation
2015 Wong,C, Lee,S, Gan,S, Mahajan,R, Pathak,R, Brooks,A, Roberts-Thomson,K, Brown,A, Lau,D, Sanders,P et al, 2015, Guideline adherence to anticoagulation for atrial fibrillation: a study in indigenous and non-indigenous Australians, Congress of the European-Society-of-Cardiology (ESC), London, ENGLAND

Conference Items

Date Citation
2016 Agbaedeng,T, Mahajan,R, Munawar,D, Elliott,A, Twomey,D, Kumar,S, Lau,D, Sanders,P, 2016, Meta-analysis of effects of epicardial fat on atrial fibrillation and ablation outcome, Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Adelaide, Australia 10.1016/j.hlc.2016.06.355
2011 Lim,H, Willoughby,S, Schultz,C, Alasady,M, Lau,D, Roberts-Thomson,K, Young,G, Sanders,P, 2011, The Effect of Acute Onset Atrial Fibrillation and Rapid Atrial Rates on Markers of Thrombogenesis in the Human Left Atrium 10.4020/jhrs.27.OP19_2
2009 Lau,DH, Mackenzie,L, Kelly,DJ, Psaltis,PJ, Worthington,M, Rajendram,A, Kelly,DR, Kuklik,P, Nelson,AJ, Zhang,Y et al, 2009, Hypertension and atrial fibrillation: a long term study of remodeling in a conscious ovine model, 82nd Scientific Session of the American Heart Association, Orlando, FL

Dr Lau is actively involved in international multicentre clinical trials as institutional co-PI in the leadless pacemaker IDE study (LEADLESS II) and co-investigator in numerous studies such as the ProMRI-PROVEN, CABANA, DIAGRAF, Reveal LinQ, CAAN-AF & HELP-AF.

Personal funding: Postgraduate Scholarships (2006-2009) - University of Adelaide, Kidney Health Australia and NHMRC; Postdoctoral Fellowship (2010-2014) - CRB Blackburn Overseas Travelling Fellowship from The Royal Australasian College of Physicians and NHMRC overseas training fellowship.

Research funding: St Jude Medical Australia (2006), Cardio Vascular Lipid Research Grant (2007), Royal Adelaide Hospital Research Foundation Research Grant (2014), Ramaciotti Establishment Grant (2014), Heart Foundation (SA) Tom Simpson Trust Fund (2013 & 2016) and The University of Adelaide School of Medicine Small Equipment Grant (2016).

 

Regular teaching and mentoring of 4-5th year medical student joining the cardiac electrophysiology rotation.

Continuing education for community pharmacists, Pharmaceutical Society of Australia (2014-current).

Short term medical work & teaching in Goma, Democratic Republic of Congo (2007).

Dr Lau has received numerous invitations to present (35 in the last 5 years) and chair at scientific meetings both locally and internationally including: Heart Rhythm Society, USA, The Asia-Pacific Heart Rhythm Society, Venice Arrhythmias, 4 Corners of Cardiology & Heart Foundation Australia. More recently, Dr Lau has also been invited to participate in writing committees of position statements/expert consensus papers at an international level on: Translational Electrophysiology Research (European Heart Rhythm Association), Cardiac Dysautonomic Syndromes (Heart Rhythm Society, USA) & Novel anticoagulation use in patient undergoing cardiac interventions (European Heart Rhythm Association).

He has been a primary/co-supervisor for doctoral candidates (5 successfully completed, 8 ongoing). In addition, he provides mentorship to cardiac technician and junior mendical staff in both learning and practising medicine.  

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