Tongzhi Wu
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
The gut (stomach and intestines) is central to the control of blood glucose and appetite, and therefore represents a logical, yet relatively unexplored, target for novel and improved treatments for type 2 diabetes mellitus (T2DM) and obesity. Dr Wu's research program utilises mutidisciplinary techniques to provide important insights into how nutrients, and particularly bitter tasting compounds, can intereact with specific diabetes medicines for therapeutic gain.
Dr Tongzhi Wu leads a research team within the NHMRC Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health at the University of Adelaide, to gain an improved understanding on how ingested nutrients interact with the gut in health and disease and whether this can be translated into safe and improved treatments for type 2 diabetes. He is particularly interested in how the gut “tastes” meal contents, especially bitter tasting substances and the mechanisms by which specific anti-diabetic drugs (e.g. metformin, DPP-4 inhibitors) interact with the gut. His research has been funded by the National Health and Medical Research Council (NHMRC), Diabetes Australia, the Royal Adelaide Hospital (RAH) Research Foundation, and the University of Adelaide.
Dr Wu is currently undertaking a number of studies to:
- define the roles of intestinal bitter taste sensing in the regulation of gastrointestinal hormone secretion, energy intake and postprandial glycaemia, and the implications for T2DM therapy; and
- clarify the role of bile acids in the anti-diabetic action of metformin.
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Appointments
Date Position Institution name 2021 Associate Professor The University of Adelaide 2020 THRF Mid-Career Fellow University of Adelaide 2018 - 2020 Adjunct Senior Fellow University of Adelaide, Adelaide 2018 - 2020 Royal Adelaide Hospital Florey Fellow Royal Adelaide Hospital, Adelaide 2015 - 2017 Royal Adelaide Hospital Mary Overton Fellow University of Adelaide 2014 - 2014 NHMRC Clinical Research Fellow University of Adelaide, Adelaide 2007 - 2009 Physician Trainee Zhongda Hospital Southeast University 2006 - 2007 Intern (First Class) Zhongda Hospital Southeast University -
Awards and Achievements
Date Type Title Institution Name Country Amount 2020 Fellowship THRF Mid-Career Fellowship The Hospital Research Foundation Australia — 2019 Award Clinical Science Poster Award Australian Diabetes Society Australia — 2019 Award Travel Award European Association for the Study of Diabetes Germany — 2018 Award Northern Communities Health Foundation Derek Frewin Early Career Research Award Northern Communities Health Foundation Australia — 2018 Fellowship Royal Adelaide Hospital Florey Fellowship Royal Adelaide Hospital Research Committee Australia — 2016 Award Executive Dean's Award for Research Excellence (Early Career Researcher) The University of Adelaide — — 2016 Award Travel Award European Association for the Study of Diabetes — €1500 2016 Award Travel Award University of Adelaide, School of Medicine Australia 2835 2015 Fellowship Early Career Fellowship Royal Adelaide Hospital Australia — 2015 Recognition Best Poster Australian Diabetes Society Australia — 2015 Award Travel Grant University of Adelaide, Discipline of Medicine Australia — 2014 Research Award University Doctoral Research Medal University of Adelaide Australia — 2013 Fellowship Travelling Fellowship University of Adelaide, Discipline of Medicine Australia 2600 2013 Award Travel Award, Diabetes Congress International Diabetes Federation (IDF) Australia — 2013 Recognition Dean's commendation for thesis excellence University of Adelaide Australia — 2012 Award Travel Award European Association for the Study of Diabetes — €2000 2011 Award Travel Award European Association for the Study of Diabetes — €2000 2011 Fellowship Postgraduate Travelling Fellowship University of Adelaide Australia 1700 2010 Recognition Best Poster Presentation University of Adelaide, Research Expo Australia — 2009 Recognition Outstanding Postgraduate in Clinical Medicine Southeast University Australia — 2009 Scholarship Postgraduate Scholarship China Scholarship Council China — 2009 Scholarship Postgraduate Supplementary Scholarship Centre of Research Excellence in Translating Nutritional Science to Good Health Australia — 2007 Scholarship First-class postgraduate scholarship Southeast University China — 2007 Recognition Outstanding Graduate in Clinical Medicine Southeast University China — 2006 Recognition 'Excellent Student Researcher' in the Student Research Training Program (SRTP) Southeast University China — 2004 Scholarship 'Zi-guang' Scholarship Southeast University Australia — -
Education
Date Institution name Country Title 2009 - 2013 University of Adelaide Australia Doctor of Philosophy 2007 - 2009 Southeast University China Master of Clinical Medicine 2002 - 2007 Southeast University China Bachelor of Clinical Medicine -
Research Interests
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Journals
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Book Chapters
Year Citation 2017 Watson, L., Wu, T., Horowitz, M., & Rayner, C. (2017). Whey Protein and Diabetes. In R. Watson, R. Collier, & V. Preedy (Eds.), Dairy in Human Health and Disease across the Lifespan (pp. 197-209). United Kingdom: Academic Press.
Scopus22016 Wu, T., Rayner, C., & Horowitz, M. (2016). Incretins. In S. Herzig (Ed.), Metabolic Control (Vol. 233, pp. 137-171). Switzerland: Springer.
Scopus37 Europe PMC162010 Wu, T., Rayner, C. K., Jones, K., & Horowitz, M. (2010). Dietary Effects on Incretin Hormone Secretion. In Incretins and Insulin Secretion (pp. 81-110). Elsevier.
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Conference Papers
Year Citation 2018 Borg, M. J., Rayner, C. K., Horowitz, M., Jones, K. L., & Wu, T. (2018). Metformin attenuates the fall in postprandial blood pressure and slows gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S112). Berlin, GERMANY: SPRINGER. 2018 Rayner, C. K., Watson, L. E., Phillips, L. K., Bound, M. J., Grivell, J., Wu, T., . . . Natali, A. (2018). Effects of sustained treatment with lixisenatide on gastric emptying and glucose metabolism in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S386-S387). Berlin, GERMANY: SPRINGER. 2018 Trahair, L., Nauck, M., Wu, T., Buttfield, M., Stevens, J., Hatzinikolas, S., . . . Jones, K. (2018). Measurement of gastric emptying using scintigraphy and a C-13-octanoic acid breath test with Wagner-Nelson analysis in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S338-S339). Berlin, GERMANY: SPRINGER.
WoS12015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz., Jones, K. L., & Rayner, C. K. (2015). Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes. In Diabetes. Adelaide. 2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz, M., Jones, K. L., & Rayner, C. K. (2015). Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes. In Diabetes. Adelaide. 2012 Bound, M., Wu, T., Gedulin, B., Horowitz, M., & Rayner, C. (2012). Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans. In Diabetologia Vol. 55 (pp. S338). Germany: Springer.
2012 Zhao, R., Wu, T., Jones, K., Horowitz, M., & Rayner, C. (2012). Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes. In Journal of Gastroenterology and Hepatology Vol. 27 (pp. 148-149). Australia: Wiley-Blackwell.
2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER. 2010 Ma, J., Wu, T., Checklin, H., Wishart, J., Stevens, J., Jones, K., . . . Rayner, C. (2010). Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A114-A115). WILEY-BLACKWELL PUBLISHING, INC. 2010 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2010). Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A105). WILEY-BLACKWELL PUBLISHING, INC. -
Conference Items
Year Citation 2020 Wang, X., Chen, C., Xie, C., Horowitz, M., Jones, K., Rayner, C., . . . Wu, T. (2020). Serum bile acids after an oral glucose load in Chinese healthy individuals and patients with type 2 diabetes: relationships with glycaemia. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Xie, C., Wang, X., Bound, M., Young, R., Jones, K., Horowitz, M., . . . Wu, T. (2020). Bitter taste signalling modulates bile acid-induced PYY, but not GLP-1 secretion in healthy humans. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Wu, T., Xie, C., Wang, X., Bound, M., Grivell, J., Jones, K., . . . Rayner, C. (2020). Role of endogenous glucagon-like peptide-1 in the serum triglyceride response to intraduodenal fat infusion in type 2 diabetic patients on vildagliptin. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Sansome, D., Veedfald, S., Xie, C., Bound, M., Grivell, J., Jones, K., . . . Wu, T. (2020). Role of bile acids on glucose-lowering by metformin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Huynh, L., Ng, S., Xie, D., Hargreaves, M., Murthy, T. A., Wu, T., . . . Marathe, C. (2020). Diabetes distress is associated with gastrointestinal symptoms in type 1 diabetes. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Bizzotto, R., Rayner, C. K., Watson, L. E., Phillips, L. K., Lange, K., Bound, M. J., . . . Mari, A. (2020). Comparison of paracetamol absorption and gastric emptying measured by scintigraphy in relation to rate of appearance of oral glucose and postprandial glycaemia. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER. 2020 Wu, T., Wang, X., Xie, C., Marathe, C. S., Malbert, C. -H., Horowitz, M., . . . Sun, Z. (2020). Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY. 2019 Jalleh, R., Pham, H., Marathe, C., Wu, T., Buttfield, M., Hatzinikolas, S., . . . Jones, K. (2019). Acute effects of lixisenatide on intragastric meal distribution: impact on energy intake. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER. 2019 Jones, K., Huynh, L., Hatzinikolas, S., Rigda, R., Phillips, L., Pham, H., . . . Horowitz, M. (2019). Effect of exenatide once-weekly (QW) on gastric emptying in health: impact on glycaemia and glucose absorption. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
WoS12019 Huynh, L., Pham, H., Holen, I., Hatzinikolas, S., Phillips, L., Wu, T., . . . Jones, K. (2019). Effects of a guar/whey preload on gastric emptying and glycaemic responses to oral glucose in healthy older people. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER. 2019 Xie, C., Wang, X., Bound, M., Grivell, J., Jones, K., Horowitz, M., . . . Wu, T. (2019). Roles of endogenous GLP-1 in the glycaemic and energy expenditure responses to fat in type 2 diabetes studied using vildagliptin and exendin(9-39). Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER. 2019 Marathe, C., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Wu, T., . . . Jones, K. (2019). Acute administration of lixisenatide diminishes the insulin secretory response to oral glucose by slowing gastric emptying. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER. 2019 Marathe, J., Pham, H., Trahair, L., Huynh, L., Wu, T., Rayner, C., . . . Marathe, C. (2019). Relationships between GIP and GLP-1 secretion in people with normal or impaired glucose tolerance. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER. 2019 Horowitz, M., Xie, C., Wang, X., Bound, M. J., Grivell, J., Jones, K. L., . . . Wu, T. (2019). Comparative effects of intraduodenal glucose and fat on blood pressure and heart rate in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Barcelona, SPAIN: Springer-Verlag.
2019 Wu, T., Zhang, X., Horowitz, M., Jones, K., & Rayner, C. (2019). Comparative effects of proximal and distal small intestinal glucose exposure on blood pressure, heart rate and mesenteric blood flow in health and type 2 diabetes. Poster session presented at the meeting of Diabetologia. Barcelona, Spain: Springer. 2018 Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J., . . . Rayner, C. (2018). Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY. 2018 Wu, T., Borg, M., Jones, K., Horowitz, M., & Rayner, C. (2018). Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and GLP-1, and gastric emptying after oral glucose in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Berlin, GERMANY: SPRINGER. 2018 Xie, C., Wang, X., Bound, M., Grivell, J., Young, R., Jones, K., . . . Wu, T. (2018). Effects of the bitter taste receptor agonist, denatonium benzoate, on postprandial glycaemia, gastric emptying and energy intake in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
2018 Jones, K., Stevens, J., Buttfield, M., Wu, T., Hatzinikolas, S., Pham, H., . . . Horowitz, M. (2018). The reduction in postprandial glucose by sitagliptin is related to the rate of gastric emptying in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Berlin, GERMANY: SPRINGER. 2018 Young, R., Kreuch, D., Mobegi, F., Leong, L., Schober, G., Isaacs, N., . . . Rogers, G. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
2017 Phillips, L., Watson, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2017). Longitudinal evaluation of gastric emptying in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
2017 Jones, K., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Marathe, C., . . . Horowitz, M. (2017). Acute effects of lixisenatide on gastric emptying, glycaemia and 'postprandial' blood pressure responses to an oral glucose load in healthy subjects and type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
WoS12017 Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
WoS22017 Rayner, C., Wu, T., Horowitz, M., & Jones, K. (2017). Blockade of glucagon-like peptide-1 receptors by exendin(9-39) attenuates the increase in heart rate during small intestinal glucose infusion in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
WoS12017 Wu, T., Horowitz, M., Jones, K., & Rayner, C. (2017). Endogenous glucagon-like peptide-1 mediates the lowering of glycaemia during small intestinal glucose infusion by bile acids in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
WoS22017 Buttfield, M., Stevens, J., Hatzinikolas, S., Wu, T., Pham, H., Lange, K., . . . Jones, K. (2017). EFFECTS OF SITAGLIPTIN ON GASTRIC EMPTYING OF, AND THE BLOOD PRESSURE RESPONSE TO, A CARBOHYDRATE MEAL IN TYPE 2 DIABETES. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY. 2016 Chen, C., Hu, B., Wu, T., & Jiang, H. (2016). Targeted metabolomics study on bile acid profiles in db/db mice and their wild type littermates. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER. 2016 Zhang, X., Bound, M., Standfield, S., Hu, S., Jones, K., Horowitz, M., . . . Wu, T. (2016). Comparative effects of proximal and distal small intestinal glucose on glycaemia, incretin hormone secretion and incretin effect in healthy males. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag.
WoS22016 Wu, T., Zhang, X., Little, T., Bound, M., Standfield, S., Deacon, C., . . . Rayner, C. (2016). The rate of intraduodenal glucose delivery affects the lowering of blood glucose by vildagliptin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER. 2016 Mignone, L., Wu, T., Phillips, L., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2016). A whey/guar "preload" improves postprandial glycaemia and HbA(1c) in type 2 diabetes: a 12-week, single-blind, randomised and placebo controlled trial. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag.
2014 Mignone, L., Wu, T., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2014). A low-dose whey protein preload slows gastric emptying and improves post-prandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. 2014 Wu, T., Bound, M., Deacon, C., Jones, K., Horowitz, M., & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. 2012 He, J., Sun, Z., Wu, T., Xie, Z., Lu, Y., Lei, C., . . . Zhou, Y. (2012). Screening for diabetes and pre-diabetes with combined use of FPG and quantitative postprandial urine glucose in Chinese high-risk population: a community-based study. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. 2012 Wu, T., Zhao, B., Horowitz, M., Jones, K., & Rayner, C. (2012). Effects of a xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER. 2012 Young, R., Chia, B., Wu, T., Michael, H., & Rayner, C. (2012). Loss of intestinal sweet taste receptor control in type 2 diabetes: A risk factor for postprandial hyperglycemia?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2020 – 22 The Hospital Research Foundation Mid-Career Fellowship ( $479,888) Tongzhi Wu
2020 Diabetes Australia Project Grant (Y20G-WUTO) ($59,970)
Project title: Effects of endogenous bile acids on postprandial glucose metabolism in type 2 diabetes, and the impact of the small intestinal region exposed
Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz
2020 Royal Adelaide Hospital Research Committee Clinical Project Grant ($48,286)
Project title: GLP-1 for lowering plasma glucose in type 2 diabetes: A systemic comparison of intravenous and subcutaneous routes
Chris Rayner, Daniel Quast, Tongzhi Wu
2020 Royal Adelaide Hospital Research Committee Clinical Project Grant ($50,000)
Project title: Effects of endogenous bile acids on postprandial glucose metabolism in health, and the impact of the small intestinal region exposed
Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz
2020 Diabetes Australia Project Grant (Y20G-YOUR) ($59,762)
Project title: Does the gut microbiome link intake of low-calorie sweeteners to impaired blood glucose control?
Richard Young, Geraint Rogers, Chris Rayner, Michael Horowitz, Tongzhi Wu
2020-21 Diabetes Australia Project Grant (Y20G-WUTO) ($59,970)
Project title: Effects of endogenous bile acids on postprandial glucose metabolism in type 2 diabetes, and the impact of the small intestinal region exposed
Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz
2019 – 20 Diabetes Australia Project Grant (Y19G-WUTO) ($59,991)
Project title: Role of bile acids in glucose-lowering by metformin
Tongzhi Wu, Chris Rayner, Karen Jones, Michael Horowitz
2019 – 21 RAH Research Foundation Clinical Project Grant ($49,998)
Project title: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes.
Tongzhi Wu, Liza Phillips, Chris Rayner, Karen Jones, Michael Horowitz
2019 Diabetes Australia Project Grant (Y19G-JONK) ($59,872)
Project title: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, an oral glucose load in type 2 diabetes.
Karen Jones, Liza Phillips, Tongzhi Wu, Chinmay Marathe, Michael Howoritz, Chris Rayner.
2018 – 21 NHMRC Project Grant (APP1147333) ($725,276)
Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.
CIA: Tongzhi Wu, CIB: Chris Rayner, CIC: Karen Jones, CID: Richard Young, CIE: Christine Feinle-Bisset
2018 – 20 Royal Adelaide Hospital (RAH) Research Foundation Florey Fellowship ($348,000) Tongzhi Wu
2018 – 19 Diabetes Australia Millennium Grant ($150,000)
Project title:Do artificial sweeteners affect glycaemic control in T2DM adversely?
Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu
2018 RAH Research Foundation Clinical Project Grant ($49,472)
Project title: Role of endogenous glucose-dependent insulinotropic polypeptide in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects.
Karen Jones, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz
2018 RAH Research Foundation Clinical Project Grant ($49,710)
Project title: Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes.
Richard Young, Nam Nguyen, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, CIE: Michael Horowitz
2017 – 18 University of Adelaide Early Career Researcher Mentored Project Grant ($14,992)
Project title: Nutrient-gut interactions and glycaemic control in type 2 diabetes.
Tongzhi Wu
2017 – 18 Project Development Grant of the NHMRC CRE in Translating Nutritional Science to Good Health ($32,610)
Project title: Stimulating intestinal bitter taste receptors for control of type 2 diabetes
Tongzhi Wu
2017 – 18 Diabetes Australia project grant (Y17G-WUTO) ($59,270)
Project title: Gastrointestinal mechanisms of the anti-diabetic effect of metformin.
Tongzhi Wu,Chris Rayner, Michael Horowitz
2017 University of Adelaide Research Infrastructure Awards ($26,410)
Project title: LOGIQ eR7 Ultrasound System to measure 2D and Doppler ultrasound in nutrition research.
Karen Jones, Chris Rayner Christine Feinle-Bisset, Tongzhi Wu, Stijn Soenen
2016 – 17 RAH Research Foundation Clinical Project Grant ($49,258)
Project title: Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans?
Tongzhi Wu, Chris Rayner
2015 – 17 RAH Research Committee Early Career Fellowship ($252,000)
Project title: The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes
Tongzhi Wu
2015 The University of Adelaide Interdisciplinary Seed Funding
Project title: Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cells. Jiangbo Zhao, Tongzhi Wu
2014 – 16 RAH Research Foundation Clinical Project Grant ($40,000)
Project title: Intestinal sweet taste receptor control of glucose absorption in human health & type 2 diabetes.CIA: Richard Young, Tongzhi Wu, Chris Rayner
2014 – 16 RAH Research Foundation Clinical Project Grant ($49,700)
Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying.Karen Jones, Tongzhi Wu, Chris Rayner
2014 Clinical Research Fellowship of NHMRC CRE in Translating Nutritional Science to Good Health($80,571)
Project title: Gastrointestinal function and the management of type 2 diabetes
Tongzhi Wu
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Principal Supervisor Human gut-pancreas chip - a novel in vitro model for diabetes study Doctor of Philosophy Doctorate Full Time Mr Weikun Huang 2017 Co-Supervisor Bitter Taste Control of Blood Glucose Homeostasis Doctor of Philosophy Doctorate Full Time Mr Cong Xie -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2019 Co-Supervisor A microfluidic sensing system for simultaneous monitoring of extracellular Ca(II) and insulin secretion Master of Philosophy Master Full Time Mr Weikun Huang -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2019 - ongoing Principal Supervisor Human gut-pancreas chip - a novel in vitro model for diabetes study The University of Adelaide — Higher Doctorate Full Time Weikun Huang 2019 - ongoing Principal Supervisor Role of bile acids in glucose-lowering by metformin The University of Adelaide — Honours Full Time Daniel Sansome 2017 - ongoing Principal Supervisor Effects of the non-nutritive bitter taste flavouring, denatonium benzoate (DB), and the low-nutritive bitter taste amino acid, leucine, on gastrointestinal hormone secretion and energy intake in health and type 2 diabetes – regional differences in small intestinal exposure The University of Adelaide/Southeast University — Higher Doctorate Full Time Xuyi Wang 2017 - 2017 Principal Supervisor Gastrointestinal mechanisms of the anti-diabetic effect of metformin The University of Adelaide — Honours Full Time Malcolm Borg 2015 - 2016 Co-Supervisor Comparative effects of proximal and distal small intestinal glucose exposure on glycemia, incretin hormone secretion and the incretin effect in health and type 2 diabetes. The University of Adelaide / Shangdong University — Higher Doctorate Full Time Xiang Zhang
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Committee Memberships
Date Role Committee Institution Country 2019 - ongoing Board Member Chinese Diabetes Society - Translational Research Group Chinese Diabetes Society China 2015 - ongoing Member Australian Diabetes Society — Australia 2009 - ongoing Member European Association for the Study of Diabetes — —
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