Dr Tongzhi Wu
Dr Tongzhi Wu is an early-career research fellow within the NHMRC Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, at the University of Adelaide. His major research interest concerns gastrointestinal physiology and glycaemic control in type 2 diabetes. His research is clinically based, and has yielded important insights into the impact of gastric emptying on postprandial blood glucose regulation, the pathophysiology of the ‘incretin’ hormones (ie. glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)), and nutrient sensing within the proximal small intestine in type 2 diabetes. Based on the principles of gut physiology, he is also investigating potential dietary and/or pharmacological strategies that modify gut function to improve glycaemic control in type 2 diabetes.
Appointments
| Date | Position | Institution name |
|---|---|---|
| 2014 | Early Career Postdoctoral Fellow | University of Adelaide |
| 2007 - 2009 | Basic Physician Trainee | Zhongda Hospital Southeast University |
| 2006 - 2007 | Intern (First Class) | Zhongda Hospital Southeast University |
Awards and Achievements
| Date | Type | Title | Institution Name | Amount |
|---|---|---|---|---|
| 2016 | Executive Dean's Award for Research Excellence (Early Career Researcher) | The University of Adelaide | ||
| 2016 | Travel Award | European Association for the Study of Diabetes | ||
| 2016 | Travel Award | University of Adelaide, School of Medicine | ||
| 2015 - 2018 | Early Career Fellowship | Royal Adelaide Hospital | ||
| 2015 | Travel Grant | University of Adelaide, Discipline of Medicine | ||
| 2015 | Best Poster | Australian Diabetes Society | ||
| 2014 | University Doctoral Research Medal | University of Adelaide | ||
| 2013 | Travelling Fellowship | University of Adelaide, Discipline of Medicine | ||
| 2013 | Travel Award, Diabetes Congress | International Diabetes Federation (IDF) | ||
| 2013 | Dean's commendation for thesis excellence | University of Adelaide | ||
| 2012 | Travel Award | European Association for the Study of Diabetes | ||
| 2011 | Travel Award | European Association for the Study of Diabetes | ||
| 2011 | Postgraduate Travelling Fellowship | University of Adelaide | ||
| 2010 | Best Poster Presentation | University of Adelaide, Research Expo | ||
| 2009 - 2013 | Postgraduate Scholarship | China Scholarship Council | ||
| 2009 | Outstanding Postgraduate in Clinical Medicine | Southeast University | ||
| 2009 - 2013 | Postgraduate Supplementary Scholarship | Centre of Research Excellence in Translating Nutritional Science to Good Health | ||
| 2007 | Outstanding Graduate in Clinical Medicine | Southeast University | ||
| 2007 - 2009 | First-class postgraduate scholarship | Southeast University | ||
| 2006 | 'Excellent Student Researcher' in the Student Research Training Program (SRTP) | Southeast University | ||
| 2004 | 'Zi-guang' Scholarship | Southeast University |
Education
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2009 - 2013 | University of Adelaide | Australia | Doctor of Philosophy |
| 2007 - 2009 | Southeast University | China | Master of Clinical Medicine |
| 2002 - 2007 | Southeast University | China | Bachelor of Clinical Medicine |
Journals
| Date | Citation |
|---|---|
| 2017 | Wu,T, Horowitz,M, Rayner,C, 2017, New insights into the anti-diabetic actions of metformin: from the liver to the gut, Expert Review of Gastroenterology and Hepatology, 11, 2, 157-166 10.1080/17474124.2017.1273769 |
| 2017 | Wu,T, Xie,C, Wu,H, Jones,K, Horowitz,M, Rayner,C, 2017, Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes, Diabetes, Obesity and Metabolism, 19, 2, 290-293 10.1111/dom.12812 |
| 2017 | Thazhath,S, Marathe,C, Wu,T, Chang,J, Khoo,J, Kuo,P, Checklin,H, Bound,M, Rigda,R, Horowitz,M et al, 2017, Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes, Diabetes and Vascular Disease Research, 14, 1, 59-63 10.1177/1479164116666761 |
| 2017 | Rayner,C, Jones,K, Wu,T, Horowitz,M, 2017, Gut feelings about diabetes and GLP-1 receptor agonists: lessons to be learnt from studies in functional gastrointestinal disorders, Diabetes, Obesity and Metabolism, 19, 3, 309-312 10.1111/dom.12822 |
| 2017 | Wu,T, Trahair,L, Little,T, Bound,M, Zhang,X, Wu,H, Sun,Z, Horowitz,M, Rayner,C, Jones,K et al, 2017, Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes., Diabetes Care, 40, 5, 702-705 10.2337/dc16-2391 |
| 2016 | Wu,T, Rayner,C, Horowitz,M, 2016, Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control, Biomarkers in Medicine, 10, 11, 1167-1179 10.2217/bmm-2016-0164 |
| 2016 | Thazhath,S, Wu,T, Bound,M, Checklin,H, Standfield,S, Jones,K, Horowitz,M, Rayner,C, 2016, Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: a randomised controlled trial, Nutrition, 32, 5, 553-559 10.1016/j.nut.2015.11.004 |
| 2016 | Thazhath,S, Marathe,C, Wu,T, Chang,J, Khoo,J, Kuo,P, Checklin,H, Bound,M, Rigda,R, Crouch,B et al, 2016, The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal motility, flow, transit, and absorption of glucose in healthy subjects and patients with type 2 diabetes: a randomized controlled trial, Diabetes, 65, 1, 269-275 10.2337/db15-0893 |
| 2016 | Rigda,R, Trahair,L, Little,T, Wu,T, Standfield,S, Feinle-Bisset,C, Rayner,C, Horowitz,M, Jones,K, 2016, Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects, Peptides, 86, 126-132 10.1016/j.peptides.2016.10.010 |
| 2016 | Thazhath,S, Wu,T, Bound,M, Checklin,H, Standfield,S, Jones,K, Horowitz,M, Rayner,C, 2016, Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial, American Journal of Clinical Nutrition, 103, 1, 66-70 10.3945/ajcn.115.117440 |
| 2016 | Zhang,X, Liu,T, Wang,Y, Zhong,M, Zhang,G, Liu,S, Wu,T, Rayner,C, Hu,S, 2016, Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats, Obesity Surgery, 26, 7, 1565-1575 10.1007/s11695-015-1925-y |
| 2016 | Wu,T, Little,T, Bound,M, Borg,M, Zhang,X, Deacon,C, Horowitz,M, Jones,K, Rayner,C, 2016, A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes, Diabetes Care, 39, 4, 511-517 10.2337/dc15-2298 |
| 2016 | Horowitz,M, Wu,T, Deane,A, Jones,K, Rayner,C, 2016, DPP-4 inhibition and the known unknown, Diabetes, 65, 8, 2124-2126 10.2337/dbi16-0023 |
| 2016 | Wu,T, Zhang,X, Trahair,L, Bound,M, Little,T, Deacon,C, Horowitz,M, Jones,K, Rayner,C, 2016, Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes, Journal of Clinical Endocrinology and Metabolism, 101, 12, 4769-4778 10.1210/jc.2016-2813 |
| 2016 | Chen,C, Hu,B, Wu,T, Zhang,Y, Xu,Y, Feng,Y, Jiang,H, 2016, Bile acid profiles in diabetic (db/db) mice and their wild type littermates, Journal of Pharmaceutical and Biomedical Analysis, 131, 473-481 10.1016/j.jpba.2016.09.023 |
| 2015 | Yang,B, Lu,Y, He,J, Wu,T, Xie,Z, Lei,C, Zhou,Y, Han,J, Bian,M, You,H et al, 2015, Performance of fasting plasma glucose and postprandial urine glucose in screening for diabetes in Chinese high‑risk population, Chinese Medical Journal, 128, 24, 3270-3275 10.4103/0366-6999.171353 |
| 2015 | Wu,T, Thazhath,S, Marathe,C, Bound,M, Jones,K, Horowitz,M, Rayner,C, 2015, Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males, Nutrition and Diabetes, 5, 5, e156-1-e156-4 10.1038/nutd.2015.6 |
| 2015 | Wu,T, Trahair,L, Bound,M, Deacon,C, Horowitz,M, Rayner,C, Jones,K, 2015, Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?, Diabetic Medicine, 32, 5, 595-600 10.1111/dme.12622 |
| 2015 | Mignone,LE, Wu,T, Horowitz,M, Rayner,CK, 2015, Whey protein: The "whey" forward for treatment of type 2 diabetes?, World journal of diabetes, 6, 14, 1274-1284 10.4239/wjd.v6.i14.1274 |
| 2014 | Thazhath,S, Wu,T, Bound,M, Checklin,H, Jones,K, Willoughby,S, Horowitz,M, Rayner,C, 2014, Changes in meal composition and duration affect postprandial endothelial function in healthy humans, American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, 12, G1191-G1197 10.1152/ajpgi.00323.2014 |
| 2014 | Thazhath,S, Wu,T, Young,R, Horowitz,M, Rayner,C, 2014, Glucose absorption in small intestinal diseases, Expert Review of Gastroenterology and Hepatology, 8, 3, 301-312 10.1586/17474124.2014.887439 |
| 2014 | Wu,T, Ma,J, Bound,M, Checklin,H, Deacon,C, Jones,K, Horowitz,M, Rayner,C, 2014, Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin, Diabetes, 63, 8, 2776-2787 10.2337/db13-1627 |
| 2014 | Wu,T, Thazhath,S, Bound,M, Jones,K, Horowitz,M, Rayner,C, 2014, Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?, Diabetes Research and Clinical Practice, 106, 1, e3-e6 10.1016/j.diabres.2014.08.004 |
| 2013 | Wu,T, Bound,M, Zhao,R, Standfield,S, Bellon,M, Jones,K, Horowitz,M, Rayner,C, 2013, Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes, Diabetes Care, 36, 7, 1913-1918 10.2337/dc12-2294 |
| 2013 | Chang,J, Wu,T, Greenfield,J, Samocha-Bonet,D, Horowitz,M, Rayner,C, 2013, Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes, Diabetes Care, 36, 8, 2262-2265 10.2337/dc12-1663 |
| 2013 | Wu,T, Rayner,C, Young,R, Horowitz,M, 2013, Gut motility and enteroendocrine secretion, Current Opinion in Pharmacology, 13, 6, 928-934 10.1016/j.coph.2013.09.002 |
| 2013 | Wu,T, Bound,M, Standfield,S, Gedulin,B, Jones,K, Horowitz,M, Rayner,C, 2013, Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans, Diabetes Obesity & Metabolism, 15, 5, 474-477 10.1111/dom.12043 |
| 2013 | Young,R, Chia,C, Isaacs,N, Ma,J, Khoo,J, Wu,T, Horowitz,M, Rayner,C, 2013, Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes, Diabetes, 62, 10, 3532-3541 10.2337/db13-0581 |
| 2013 | Wu,T, Bound,M, Standfield,S, Jones,K, Horowitz,M, Rayner,C, 2013, Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans, Journal of Clinical Endocrinology and Metabolism, 98, 4, 718-722 10.1210/jc.2012-3961 |
| 2013 | Wu,T, Bound,M, Standfield,S, Bellon,M, Young,R, Jones,K, Horowitz,M, Rayner,C, 2013, Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans, Diabetes Care, 36, 12, e202-e203 10.2337/dc13-0958 |
| 2012 | Wu,T, Zhao,R, Bound,M, Checklin,H, Bellon,M, Little,T, Young,R, Jones,K, Horowitz,M, Rayner,C et al, 2012, Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans, American Journal of Clinical Nutrition, 95, 1, 78-83 10.3945/ajcn.111.021543 |
| 2010 | Wu,T, Rayner,CK, Jones,K, Horowitz,M, 2010, Dietary effects on incretin hormone secretion., Vitam Horm, 84, 81-110 10.1016/B978-0-12-381517-0.00003-5 |
Book Chapters
| Date | Citation |
|---|---|
| 2016 | Wu,T, Rayner,CK, Horowitz,M, 2016, Incretins, Springer, Switzerland, pp. 137-171 10.1007/164_2015_9 |
Conference Papers
| Date | Citation |
|---|---|
| 2015 | Marathe,C, Thazhath,SS, Wu,T, Horowitz,M, Jones,KL, Rayner,CK, 2015, Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes, Australian Diabetes Society, Adelaide |
| 2015 | Marathe,C, Thazhath,SS, Wu,T, Horowitz,, Jones,KL, Rayner,CK, 2015, Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes, Australian Diabetes Society, Adelaide |
| 2012 | Bound,M, Wu,T, Gedulin,B, Horowitz,M, Rayner,C, 2012, Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans, Annual Meeting of the European Association for the Study of Diabetes, Berlin 10.1007/s00125-012-2688-9 |
| 2012 | Zhao,R, Wu,T, Jones,K, Horowitz,M, Rayner,C, 2012, Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes, Australian Gastroenterology Week, Adelaide 10.1111/j.1440-1746.2011.07251_9.x |
| 2011 | Wu,T, Zhao,B, Bound,M, Checklin,H, Bellon,M, Little,T, Young,R, Jones,K, Horowitz,M, Rayner,C et al, 2011, Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans, 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon, PORTUGAL |
| 2010 | Ma,J, Wu,T, Checklin,H, Wishart,J, Stevens,J, Jones,K, Horowitz,M, Meyer,J, Rayner,C, 2010, Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes |
| 2010 | Wu,T, Zhao,B, Bound,M, Checklin,H, Bellon,M, Little,T, Young,R, Jones,K, Horowitz,M, Rayner,C et al, 2010, Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects |
Conference Items
| Date | Citation |
|---|---|
| 2017 | Buttfield,M, Stevens,J, Hatzinikolas,S, Wu,T, Pham,H, Lange,K, Rayner,C, Horowitz,M, Jones,K, 2017, EFFECTS OF SITAGLIPTIN ON GASTRIC EMPTYING OF, AND THE BLOOD PRESSURE RESPONSE TO, A CARBOHYDRATE MEAL IN TYPE 2 DIABETES |
| 2016 | Zhang,X, Bound,M, Standfield,S, Hu,S, Jones,K, Horowitz,M, Rayner,C, Wu,T, 2016, Comparative effects of proximal and distal small intestinal glucose on glycaemia, incretin hormone secretion and incretin effect in healthy males, 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Munich, GERMANY 10.1007/s00125-016-4046-9 |
| 2016 | Wu,T, Zhang,X, Little,T, Bound,M, Standfield,S, Deacon,C, Horowitz,M, Jones,K, Rayner,C, 2016, The rate of intraduodenal glucose delivery affects the lowering of blood glucose by vildagliptin in type 2 diabetes, 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Munich, GERMANY |
| 2016 | Mignone,L, Wu,T, Phillips,L, Bound,M, Checklin,H, Grivell,J, Jones,K, Clifton,P, Horowitz,M, Rayner,C et al, 2016, A whey/guar "preload" improves postprandial glycaemia and HbA(1c) in type 2 diabetes: a 12-week, single-blind, randomised and placebo controlled trial, 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Munich, GERMANY 10.1007/s00125-016-4046-9 |
| 2016 | Chen,C, Hu,B, Wu,T, Jiang,H, 2016, Targeted metabolomics study on bile acid profiles in db/db mice and their wild type littermates, 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Munich, GERMANY |
| 2014 | Wu,T, Bound,M, Deacon,C, Jones,K, Horowitz,M, Rayner,C, 2014, Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity? |
| 2014 | Mignone,L, Wu,T, Bound,M, Jones,K, Horowitz,M, Rayner,C, 2014, A low-dose whey protein preload slows gastric emptying and improves post-prandial glycaemia in type 2 diabetes |
| 2012 | He,J, Sun,Z, Wu,T, Xie,Z, Lu,Y, Lei,C, Han,J, Zhou,Y, 2012, Screening for diabetes and pre-diabetes with combined use of FPG and quantitative postprandial urine glucose in Chinese high-risk population: a community-based study |
| 2012 | Young,R, Chia,B, Wu,T, Michael,H, Rayner,C, 2012, Loss of intestinal sweet taste receptor control in type 2 diabetes: A risk factor for postprandial hyperglycemia? |
| 2012 | Wu,T, Zhao,B, Horowitz,M, Jones,K, Rayner,C, 2012, Effects of a xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in type 2 diabetes |
2017 Gastrointestinal mechanism of the anti-diabetic effect of metformin. Wu T, Rayner CK & Horowitz M. Diabetes Australia. ($59,270)
2016-17 Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans? Wu T & Rayner CK. Royal Adelaide Hospital Research Foundation. ($49,258)
2015-17 The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes. Wu T. Royal Adelaide Hospital Research Foundation. ($252,000)
2015-16 Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cell. Zhao J & Wu T. The University of Adelaide. ($22,000)
2014-15 AstraZeneca sponsored investigator initiated study – Project title: Combining saxagliptin and acarbose to improve postprandial hyperglycaemia in type 2 diabetes. Wu T & Sun Z. ($ 100,000)
2014-16 Royal Adelaide Hospital Research Foundation – Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying. Jones KL, Wu T, and Rayner CK. ($47,700)
2014-16 Royal Adelaide Hospital Research Foundation – Project title: Sweet taste receptor control of glucose absorption in human health & type 2 diabetes. Young RL, Wu T, Rayner CK. ($40,000)
Committee Memberships
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2015 | Member | Australian Diabetes Society | Australia | |
| 2009 | Member | European Association for the Study of Diabetes |
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