Dr Tongzhi Wu

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

The gut (stomach and intestines) is central to the control of blood glucose and appetite, and therefore represents a logical, yet relatively unexplored, target for novel and improved treatments for type 2 diabetes mellitus (T2DM) and obesity. Dr Wu's research program utilises mutidisciplinary techniques to provide important insights into how nutrients, and particularly bitter tasting compounds, can intereact with specific diabetes medicines for therapeutic gain.

My Research
Career
Publications
Grants and Funding
Supervision
Professional Activities
Contact

Dr Tongzhi Wu leads a research team within the NHMRC Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health at the University of Adelaide, to gain an improved understanding on how ingested nutrients interact with the gut in health and disease and whether this can be translated into safe and improved treatments for type 2 diabetes. He is particularly interested in how the gut “tastes” meal contents, especially bitter tasting substances and the mechanisms by which specific anti-diabetic drugs (e.g. metformin, DPP-4 inhibitors) interact with the gut. His research has been funded by the National Health and Medical Research Council (NHMRC), Diabetes Australia, the Royal Adelaide Hospital (RAH) Research Foundation, and the University of Adelaide.

Dr Wu is currently undertaking a number of studies to:

define the roles of intestinal bitter taste sensing in the regulation of gastrointestinal hormone secretion, energy intake and postprandial glycaemia, and the implications for T2DM therapy; and
clarify the role of bile acids in the anti-diabetic action of metformin.

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Appointments

Date	Position	Institution name
2018	Adjunct Senior Fellow	University of Adelaide, Adelaide
2018 - 2020	Royal Adelaide Hospital Florey Fellow	Royal Adelaide Hospital, Adelaide
2015 - 2017	Royal Adelaide Hospital Mary Overton Fellow	University of Adelaide
2014 - 2014	NHMRC Clinical Research Fellow	University of Adelaide, Adelaide
2007 - 2009	Physician Trainee	Zhongda Hospital Southeast University
2006 - 2007	Intern (First Class)	Zhongda Hospital Southeast University

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2018	Award	Northern Communities Health Foundation Derek Frewin Early Career Research Award	Northern Communities Health Foundation	Australia	—
2016	Award	Executive Dean's Award for Research Excellence (Early Career Researcher)	The University of Adelaide	—	—
2016	Award	Travel Award	European Association for the Study of Diabetes	—	€1500
2016	Award	Travel Award	University of Adelaide, School of Medicine	Australia	2835
2015	Fellowship	Early Career Fellowship	Royal Adelaide Hospital	Australia	—
2015	Recognition	Best Poster	Australian Diabetes Society	Australia	—
2015	Award	Travel Grant	University of Adelaide, Discipline of Medicine	Australia	—
2014	Research Award	University Doctoral Research Medal	University of Adelaide	Australia	—
2013	Recognition	Dean's commendation for thesis excellence	University of Adelaide	Australia	—
2013	Award	Travel Award, Diabetes Congress	International Diabetes Federation (IDF)	Australia	—
2013	Fellowship	Travelling Fellowship	University of Adelaide, Discipline of Medicine	Australia	2600
2012	Award	Travel Award	European Association for the Study of Diabetes	—	€2000
2011	Award	Travel Award	European Association for the Study of Diabetes	—	€2000
2011	Fellowship	Postgraduate Travelling Fellowship	University of Adelaide	Australia	1700
2010	Recognition	Best Poster Presentation	University of Adelaide, Research Expo	Australia	—
2009	Recognition	Outstanding Postgraduate in Clinical Medicine	Southeast University	Australia	—
2009	Scholarship	Postgraduate Scholarship	China Scholarship Council	China	—
2009	Scholarship	Postgraduate Supplementary Scholarship	Centre of Research Excellence in Translating Nutritional Science to Good Health	Australia	—
2007	Scholarship	First-class postgraduate scholarship	Southeast University	China	—
2007	Recognition	Outstanding Graduate in Clinical Medicine	Southeast University	China	—
2006	Recognition	'Excellent Student Researcher' in the Student Research Training Program (SRTP)	Southeast University	China	—
2004	Scholarship	'Zi-guang' Scholarship	Southeast University	Australia	—

Education

Date	Institution name	Country	Title
2009 - 2013	University of Adelaide	Australia	Doctor of Philosophy
2007 - 2009	Southeast University	China	Master of Clinical Medicine
2002 - 2007	Southeast University	China	Bachelor of Clinical Medicine

Research Interests

Clinical Trials Endocrinology & Metabolism Medical Biochemistry: Proteins and Peptides Medical Physiology Nutrition and Metabolic Health Translational Health Outcomes

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Journals

Year	Citation
2019	Borg, M. J., Bound, M., Grivell, J., Sun, Z., Jones, K., Horowitz, M., . . . Wu, T. (2019). Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon-like peptide-1, and gastric emptying after oral glucose, in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 640-647. DOI Scopus3 WoS3 Europe PMC1
2019	Shi, R., Wang, Y., An, X., Ma, J., Wu, T., Yu, X., . . . Sun, Z. (2019). Efficacy of co-administration of Liuwei Dihuang Pills and Ginkgo biloba Tablets on albuminuria in type 2 diabetes: A 24-month, multicenter, double-blind, placebo-controlled, randomized clinical trial. Frontiers in Endocrinology, 10(FEB), 7 pages. DOI
2019	Watson, L., Xie, C., Wang, X., Li, Z., Phillips, L., Sun, Z., . . . Wu, T. (2019). Gastric Emptying in Patients with Well-Controlled Type 2 Diabetes Compared with Young and Older Control Subjects Without Diabetes. Journal of Clinical Endocrinology and Metabolism, 104(8), 3311-3319. DOI
2019	Jones, K., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Marathe, C., . . . Horowitz, M. (2019). Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycaemia in healthy people and people with type 2 diabetes. Diabetes, Obesity and Metabolism, OnlinePubl(5), 1-10. DOI
2019	Borg, M., Jones, K., Sun, Z., Horowitz, M., Rayner, C., & Wu, T. (2019). Metformin attenuates the postprandial fall in blood pressure in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(5), 1251-1254. DOI Scopus1
2019	Zhang, X., Young, R. L., Bound, M., Hu, S., Jones, K. L., Horowitz, M., . . . Wu, T. (2019). Comparative effects of proximal and distal small intestinal glucose exposure on glycemia, incretin hormone secretion, and the incretin effect in health and type 2 diabetes. Diabetes Care, 42(4), 520-528. DOI Scopus3 WoS2 Europe PMC1
2019	Bitarafan, V., Fitzgerald, P. C., Little, T. J., Meyerhof, W., Wu, T., Horowitz, M., & Feinle-Bisset, C. (2019). Effects of Intraduodenal Infusion of the Bitter Tastant, Quinine, on Antropyloroduodenal Motility, Plasma Cholecystokinin, and Energy Intake in Healthy Men. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, 25(3), 413-422. DOI
2019	Watson, L. E., Phillips, L., Wu, T., Bound, M., Checklin, H. L., Grivell, J., . . . Rayner, C. (2019). A whey/guar “preload” improves postprandial glycaemia and glycated haemoglobin levels in type 2 diabetes: a 12-week, single-blind, randomized, placebo-controlled trial. Diabetes, Obesity and Metabolism, 21(4), 930-938. DOI Scopus2 WoS1 Europe PMC1
2019	Watson, L. E., Phillips, L. K., Wu, T., Bound, M. J., Jones, K. L., Horowitz, M., & Rayner, C. K. (2019). Longitudinal evaluation of gastric emptying in type 2 diabetes.. Diabetes research and clinical practice, 154, 27-34. DOI
2019	Pham, H., Marathe, C. S., Phillips, L. K., Trahair, L. G., Hatzinikolas, S., Huynh, L., . . . Jones, K. L. (2019). Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP in healthy older subjects.. The Journal of clinical endocrinology and metabolism. DOI
2018	Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018). Gut mechanisms linking intestinal sweet sensing to glycemic control. Frontiers in Endocrinology, 9, 741-1-741-11. DOI WoS2 Europe PMC1
2018	Watson, L., Phillips, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2018). Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clinical Nutrition. DOI Scopus1 Europe PMC1
2018	Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J., . . . Rayner, C. (2018). Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men. Journal of Clinical Endocrinology and Metabolism, 103(12), 4409-4418. DOI Scopus1 WoS1
2018	Xie, C., Wang, X., Young, R. L., Horowitz, M., Rayner, C. K., & Wu, T. (2018). Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control. Frontiers in Endocrinology, 9, 576-1-576-10. DOI WoS1
2018	Wu, T., Rayner, C., Marathe, C., Jones, K., & Horowitz, M. (2018). Glucagon receptor signalling–backwards and forwards. Expert Opinion on Investigational Drugs, 27(2), 135-138. DOI Scopus2 WoS1
2018	Trahair, L., Wu, T., Feinle-Bisset, C., Marathe, C., Rayner, C., Horowitz, M., & Jones, K. (2018). Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects. Physiological Reports, 6(4), e13610-1-e13610-8. DOI
2018	Wu, T., Marathe, C., Horowitz, M., Jones, K., & Rayner, C. (2018). Comment on Russell-Jones et al. diabetes care 2017;40:943-950. Comment on bowering et al. diabetes care 2017;40:951-957. Diabetes Care, 41(3), e27-e28. DOI Scopus1 WoS1
2018	Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889. DOI Scopus7 WoS6 Europe PMC5
2018	Marathe, C., Rayner, C., Wu, T., Jones, K., & Horowitz, M. (2018). Gastric emptying and the personalized management of type 1 diabetes. The Journal of Clinical Endocrinology and Metabolism, 103(9), 3503-3506. DOI Scopus1 WoS1
2018	Pham, H., Stevens, J., Rigda, R., Phillips, L., Wu, T., Hausken, T., . . . Jones, K. (2018). Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects. American Journal of Clinical Nutrition, 108(1), 156-162. DOI
2017	Wu, T., Rayner, C., Watson, L., Jones, K., Horowitz, M., & Little, T. (2017). Comparative effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males. Peptides, 95, 124-127. DOI Scopus2 WoS2
2017	Rayner, C., Jones, K., Wu, T., & Horowitz, M. (2017). Gut feelings about diabetes and GLP-1 receptor agonists: lessons to be learnt from studies in functional gastrointestinal disorders. Diabetes, Obesity and Metabolism, 19(3), 309-312. DOI Scopus5 WoS6 Europe PMC4
2017	Thazhath, S., Marathe, C., Wu, T., Chang, J., Khoo, J., Kuo, P., . . . Rayner, C. (2017). Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes. Diabetes and Vascular Disease Research, 14(1), 59-63. DOI Scopus5 WoS5 Europe PMC3
2017	Wu, T., Horowitz, M., & Rayner, C. (2017). New insights into the anti-diabetic actions of metformin: from the liver to the gut. Expert Review of Gastroenterology and Hepatology, 11(2), 157-166. DOI Scopus7 WoS6 Europe PMC4
2017	Wu, T., Trahair, L., Little, T., Bound, M., Zhang, X., Wu, H., . . . Jones, K. (2017). Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes.. Diabetes Care, 40(5), 702-705. DOI Scopus2 WoS2
2017	Wu, T., Xie, C., Wu, H., Jones, K., Horowitz, M., & Rayner, C. (2017). Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes, Obesity and Metabolism, 19(2), 290-293. DOI Scopus12 WoS13 Europe PMC11
2016	Wu, T., Rayner, C., & Horowitz, M. (2016). Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control. Biomarkers in Medicine, 10(11), 1167-1179. DOI Scopus7 WoS7 Europe PMC4
2016	Rigda, R., Trahair, L., Little, T., Wu, T., Standfield, S., Feinle-Bisset, C., . . . Jones, K. (2016). Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects. Peptides, 86, 126-132. DOI
2016	Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K., . . . Rayner, C. (2016). Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. American Journal of Clinical Nutrition, 103(1), 66-70. DOI Scopus32 WoS32 Europe PMC22
2016	Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K., . . . Rayner, C. (2016). Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: a randomised controlled trial. Nutrition, 32(5), 553-559. DOI Scopus3 WoS4 Europe PMC2
2016	Wu, T., Little, T., Bound, M., Borg, M., Zhang, X., Deacon, C., . . . Rayner, C. (2016). A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes. Diabetes Care, 39(4), 511-517. DOI Scopus27 WoS24 Europe PMC16
2016	Horowitz, M., Wu, T., Deane, A., Jones, K., & Rayner, C. (2016). DPP-4 inhibition and the known unknown. Diabetes, 65(8), 2124-2126. DOI Scopus3 WoS3 Europe PMC3
2016	Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, C., . . . Rayner, C. (2016). Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 101(12), 4769-4778. DOI Scopus3 WoS3
2016	Chen, C., Hu, B., Wu, T., Zhang, Y., Xu, Y., Feng, Y., & Jiang, H. (2016). Bile acid profiles in diabetic (db/db) mice and their wild type littermates. Journal of Pharmaceutical and Biomedical Analysis, 131, 473-481. DOI Scopus4 WoS3 Europe PMC2
2016	Thazhath, S., Marathe, C., Wu, T., Chang, J., Khoo, J., Kuo, P., . . . Rayner, C. (2016). The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal motility, flow, transit, and absorption of glucose in healthy subjects and patients with type 2 diabetes: a randomized controlled trial. Diabetes, 65(1), 269-275. DOI Scopus21 WoS22 Europe PMC15
2016	Zhang, X., Liu, T., Wang, Y., Zhong, M., Zhang, G., Liu, S., . . . Hu, S. (2016). Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats. Obesity Surgery, 26(7), 1565-1575. DOI Scopus4 WoS4 Europe PMC4
2015	Mignone, L., Wu, T., Horowitz, M., & Rayner, C. (2015). Whey protein: The "whey" forward for treatment of type 2 diabetes?. World Journal of Diabetes, 6(14), 1274-1284. DOI Scopus9 Europe PMC10
2015	Wu, T., Thazhath, S., Marathe, C., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2015). Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition and Diabetes, 5(5), e156-1-e156-4. DOI Scopus13 WoS8 Europe PMC5
2015	Yang, B., Lu, Y., He, J., Wu, T., Xie, Z., Lei, C., . . . Sun, Z. (2015). Performance of fasting plasma glucose and postprandial urine glucose in screening for diabetes in Chinese high‑risk population. Chinese Medical Journal, 128(24), 3270-3275. DOI Scopus3 Europe PMC3
2015	Wu, T., Trahair, L., Bound, M., Deacon, C., Horowitz, M., Rayner, C., & Jones, K. (2015). Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?. Diabetic Medicine, 32(5), 595-600. DOI Scopus2 WoS2 Europe PMC1
2014	Thazhath, S., Wu, T., Bound, M., Checklin, H., Jones, K., Willoughby, S., . . . Rayner, C. (2014). Changes in meal composition and duration affect postprandial endothelial function in healthy humans. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(12), G1191-G1197. DOI Scopus3 WoS3 Europe PMC2
2014	Wu, T., Thazhath, S., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Diabetes Research and Clinical Practice, 106(1), e3-e6. DOI Scopus25 WoS27 Europe PMC22
2014	Wu, T., Ma, J., Bound, M., Checklin, H., Deacon, C., Jones, K., . . . Rayner, C. (2014). Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin. Diabetes, 63(8), 2776-2787. DOI Scopus28 WoS29 Europe PMC18
2014	Thazhath, S., Wu, T., Young, R., Horowitz, M., & Rayner, C. (2014). Glucose absorption in small intestinal diseases. Expert Review of Gastroenterology and Hepatology, 8(3), 301-312. DOI Scopus7 WoS6 Europe PMC4
2013	Wu, T., Bound, M., Standfield, S., Jones, K., Horowitz, M., & Rayner, C. (2013). Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans. Journal of Clinical Endocrinology and Metabolism, 98(4), 718-722. DOI Scopus42 WoS40 Europe PMC33
2013	Wu, T., Bound, M., Standfield, S., Gedulin, B., Jones, K., Horowitz, M., & Rayner, C. (2013). Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes Obesity & Metabolism, 15(5), 474-477. DOI Scopus58 WoS60 Europe PMC40
2013	Wu, T., Bound, M., Standfield, S., Bellon, M., Young, R., Jones, K., . . . Rayner, C. (2013). Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care, 36(12), e202-e203. DOI Scopus23 WoS25 Europe PMC15
2013	Wu, T., Rayner, C., Young, R., & Horowitz, M. (2013). Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology, 13(6), 928-934. DOI Scopus24 WoS25 Europe PMC16
2013	Chang, J., Wu, T., Greenfield, J., Samocha-Bonet, D., Horowitz, M., & Rayner, C. (2013). Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes. Diabetes Care, 36(8), 2262-2265. DOI Scopus20 WoS23 Europe PMC16
2013	Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541. DOI Scopus55 WoS51 Europe PMC37
2013	Wu, T., Bound, M., Zhao, R., Standfield, S., Bellon, M., Jones, K., . . . Rayner, C. (2013). Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care, 36(7), 1913-1918. DOI Scopus24 WoS24 Europe PMC20
2012	Wu, T., Zhao, R., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. American Journal of Clinical Nutrition, 95(1), 78-83. DOI Scopus67 WoS65 Europe PMC47
2010	Wu, T., Rayner, C., Jones, K., & Horowitz, M. (2010). Dietary effects on incretin hormone secretion. Unknown Journal, 84, 81-110. DOI Scopus30 WoS27 Europe PMC22

Book Chapters

Year	Citation
2017	Watson, L., Wu, T., Horowitz, M., & Rayner, C. (2017). Whey Protein and Diabetes. In Dairy in Human Health and Disease across the Lifespan (pp. 197-209). DOI Scopus2
2016	Wu, T., Rayner, C. K., & Horowitz, M. (2016). Incretins. In S. Herzig (Ed.), Metabolic Control (Vol. 233, pp. 137-171). Switzerland: Springer. DOI Scopus24 Europe PMC14

Conference Papers

Year	Citation
2018	Borg, M., Rayner, C., Horowitz, M., Jones, K., & Wu, T. (2018). Metformin attenuates the fall in postprandial blood pressure and slows gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S112). Berlin, GERMANY: SPRINGER.
2018	Jones, K., Stevens, J., Buttfield, M., Wu, T., Hatzinikolas, S., Pham, H., . . . Horowitz, M. (2018). The reduction in postprandial glucose by sitagliptin is related to the rate of gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S381). Berlin, GERMANY: SPRINGER.
2018	Trahair, L., Nauck, M., Wu, T., Buttfield, M., Stevens, J., Hatzinikolas, S., . . . Jones, K. (2018). Measurement of gastric emptying using scintigraphy and a C-13-octanoic acid breath test with Wagner-Nelson analysis in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S338-S339). Berlin, GERMANY: SPRINGER.
2018	Rayner, C., Watson, L., Phillips, L., Bound, M., Grivell, J., Wu, T., . . . Natali, A. (2018). Effects of sustained treatment with lixisenatide on gastric emptying and glucose metabolism in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S386-S387). Berlin, GERMANY: SPRINGER.
2015	Marathe, C., Thazhath, S. S., Wu, T., Horowitz., Jones, K. L., & Rayner, C. K. (2015). Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes. In Diabetes. Adelaide.
2015	Marathe, C., Thazhath, S. S., Wu, T., Horowitz, M., Jones, K. L., & Rayner, C. K. (2015). Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes. In Diabetes. Adelaide.
2012	Bound, M., Wu, T., Gedulin, B., Horowitz, M., & Rayner, C. (2012). Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans. In Diabetologia Vol. 55 (pp. S338). Germany: Springer. DOI
2012	Zhao, R., Wu, T., Jones, K., Horowitz, M., & Rayner, C. (2012). Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes. In Journal of Gastroenterology and Hepatology Vol. 27 (pp. 148-149). Australia: Wiley-Blackwell. DOI
2011	Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER.
2010	Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2010). Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A105). WILEY-BLACKWELL PUBLISHING, INC.
2010	Ma, J., Wu, T., Checklin, H., Wishart, J., Stevens, J., Jones, K., . . . Rayner, C. (2010). Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A114-A115). WILEY-BLACKWELL PUBLISHING, INC.

Conference Items

Year	Citation
2018	Xie, C., Wang, X., Bound, M., Grivell, J., Young, R., Jones, K., . . . Wu, T. (2018). Effects of the bitter taste receptor agonist, denatonium benzoate, on postprandial glycaemia, gastric emptying and energy intake in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2018	Young, R., Kreuch, D., Mobegi, F., Leong, L., Schober, G., Isaacs, N., . . . Rogers, G. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2018	Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J., . . . Rayner, C. (2018). Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
2018	Wu, T., Borg, M., Jones, K., Horowitz, M., & Rayner, C. (2018). Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and GLP-1, and gastric emptying after oral glucose in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Berlin, GERMANY: SPRINGER.
2017	Phillips, L., Watson, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2017). Longitudinal evaluation of gastric emptying in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2017	Jones, K., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Marathe, C., . . . Horowitz, M. (2017). Acute effects of lixisenatide on gastric emptying, glycaemia and 'postprandial' blood pressure responses to an oral glucose load in healthy subjects and type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI WoS1
2017	Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI WoS1
2017	Rayner, C., Wu, T., Horowitz, M., & Jones, K. (2017). Blockade of glucagon-like peptide-1 receptors by exendin(9-39) attenuates the increase in heart rate during small intestinal glucose infusion in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2017	Wu, T., Horowitz, M., Jones, K., & Rayner, C. (2017). Endogenous glucagon-like peptide-1 mediates the lowering of glycaemia during small intestinal glucose infusion by bile acids in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2017	Buttfield, M., Stevens, J., Hatzinikolas, S., Wu, T., Pham, H., Lange, K., . . . Jones, K. (2017). EFFECTS OF SITAGLIPTIN ON GASTRIC EMPTYING OF, AND THE BLOOD PRESSURE RESPONSE TO, A CARBOHYDRATE MEAL IN TYPE 2 DIABETES. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY.
2016	Chen, C., Hu, B., Wu, T., & Jiang, H. (2016). Targeted metabolomics study on bile acid profiles in db/db mice and their wild type littermates. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER.
2016	Zhang, X., Bound, M., Standfield, S., Hu, S., Jones, K., Horowitz, M., . . . Wu, T. (2016). Comparative effects of proximal and distal small intestinal glucose on glycaemia, incretin hormone secretion and incretin effect in healthy males. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag. DOI WoS2
2016	Wu, T., Zhang, X., Little, T., Bound, M., Standfield, S., Deacon, C., . . . Rayner, C. (2016). The rate of intraduodenal glucose delivery affects the lowering of blood glucose by vildagliptin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER.
2016	Mignone, L., Wu, T., Phillips, L., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2016). A whey/guar "preload" improves postprandial glycaemia and HbA(1c) in type 2 diabetes: a 12-week, single-blind, randomised and placebo controlled trial. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag. DOI
2014	Mignone, L., Wu, T., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2014). A low-dose whey protein preload slows gastric emptying and improves post-prandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
2014	Wu, T., Bound, M., Deacon, C., Jones, K., Horowitz, M., & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
2012	He, J., Sun, Z., Wu, T., Xie, Z., Lu, Y., Lei, C., . . . Zhou, Y. (2012). Screening for diabetes and pre-diabetes with combined use of FPG and quantitative postprandial urine glucose in Chinese high-risk population: a community-based study. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
2012	Wu, T., Zhao, B., Horowitz, M., Jones, K., & Rayner, C. (2012). Effects of a xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
2012	Young, R., Chia, B., Wu, T., Michael, H., & Rayner, C. (2012). Loss of intestinal sweet taste receptor control in type 2 diabetes: A risk factor for postprandial hyperglycemia?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.

2019 – 22 NSFC Project Grant (81870561) ( ¥570,000)

Project title: Effects of intestinal bitter taste sensing on gastrointestinal hormone secretion and glycaemic control

Tongzhi Wu, Chris Rayner, Richard Young, Qin Lu, Dong Wang, Xuyi Wang, Juan Chen, Min Cai, Min Ge

2019 Diabetes Australia Project Grant (Y19G-WUTO) ($59,991)

Project title: Role of bile acids in glucose-lowering by metformin

Tongzhi Wu, Chris Rayner, Karen Jones, Michael Horowitz

2018 – 20 NHMRC Project Grant (APP1147333) ($725,276)

Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.

CIA: Tongzhi Wu, CIB: Chris Rayner, CIC: Karen Jones, CID: Richard Young, CIE: Christine Feinle-Bisset

2018 – 20 Royal Adelaide Hospital (RAH) Research Foundation Florey Fellowship ($348,000)

Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.

CIA: Tongzhi Wu

2018 – 19 Diabetes Australia Millennium Grant ($150,000)

Project title:Do artificial sweeteners affect glycaemic control in T2DM adversely?

Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu

2018 RAH Research Foundation Clinical Project Grant ($49,472)

Project title: Role of endogenous glucose-dependent insulinotropic polypeptide in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects.

Karen Jones, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz

2018 RAH Research Foundation Clinical Project Grant ($49,710)

Project title: Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes.

Richard Young, Nam Nguyen, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, CIE: Michael Horowitz

2017 – 18 University of Adelaide Early Career Researcher Mentored Project Grant ($14,992)

Project title: Nutrient-gut interactions and glycaemic control in type 2 diabetes.

Tongzhi Wu

2017 – 18 Project Development Grant of the NHMRC CRE in Translating Nutritional Science to Good Health ($32,610)

Project title: Stimulating intestinal bitter taste receptors for control of type 2 diabetes

Tongzhi Wu

2017 – 18 Diabetes Australia project grant (Y17G-WUTO) ($59,270)

Project title: Gastrointestinal mechanisms of the anti-diabetic effect of metformin.

Tongzhi Wu,Chris Rayner, Michael Horowitz

2017 University of Adelaide Research Infrastructure Awards ($26,410)

Project title: LOGIQ eR7 Ultrasound System to measure 2D and Doppler ultrasound in nutrition research.

Karen Jones, Chris Rayner Christine Feinle-Bisset, Tongzhi Wu, Stijn Soenen

2016 – 17 RAH Research Foundation Clinical Project Grant ($49,258)

Project title: Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans?

Tongzhi Wu, Chris Rayner

2015 – 17 RAH Research Committee Early Career Fellowship ($252,000)

Project title: The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes

Tongzhi Wu

2015 The University of Adelaide Interdisciplinary Seed Funding

Project title: Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cells. Jiangbo Zhao, Tongzhi Wu

2014 – 16 RAH Research Foundation Clinical Project Grant ($40,000)

Project title: Intestinal sweet taste receptor control of glucose absorption in human health & type 2 diabetes.CIA: Richard Young, Tongzhi Wu, Chris Rayner

2014 – 16 RAH Research Foundation Clinical Project Grant ($49,700)

Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying.Karen Jones, Tongzhi Wu, Chris Rayner

2014 Clinical Research Fellowship of NHMRC CRE in Translating Nutritional Science to Good Health($80,571)

Project title: Gastrointestinal function and the management of type 2 diabetes

Tongzhi Wu

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Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2017 Co-Supervisor Bitter Taste Control of Blood Glucose Homeostasis Doctor of Philosophy Doctorate Full Time Mr Cong Xie

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2017	Co-Supervisor	Bitter Taste Control of Blood Glucose Homeostasis	Doctor of Philosophy	Doctorate	Full Time	Mr Cong Xie

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2017 - 2019	Co-Supervisor	A microfluidic sensing system for simultaneous monitoring of extracellular Ca(II) and insulin secretion	Master of Philosophy	Master	Full Time	Mr Weikun Huang

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Committee Memberships

Date Role Committee Institution Country
2015 - ongoing Member Australian Diabetes Society — Australia
2009 - ongoing Member European Association for the Study of Diabetes — —

Date	Role	Committee	Institution	Country
2015 - ongoing	Member	Australian Diabetes Society	—	Australia
2009 - ongoing	Member	European Association for the Study of Diabetes	—	—

Phone: 83136535
Email: tongzhi.wu@adelaide.edu.au
Fax: 8223 3870
Campus: North Terrace
Building: Adelaide Health and Medical Sciences, floor 6
Room: 6 061
Org Unit: Medical Specialties

Dr Tongzhi Wu

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Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

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