Tongzhi Wu

Associate Professor Tongzhi Wu

Associate Professor

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

A/Prof Wu is an emerging research leader, with a steeply rising trajectory in research on nutrient-gut interactions and type 2 diabetes. He was a top medical graduate (2009) of Southeast University (Nanjing, China), completed a University of Adelaide PhD conferred with a University Doctoral Research Medal (2013), and transformed into a research group leader during his Royal Adelaide Hospital (RAH) Mary Overton Early Career (2015-17) and Flory (2018-20) Fellowships. He was awarded a ‘top-ranked’ Mid-Career Fellowship from The Hospital Research Foundation (THRF) in 2020 and was prompted to “Associate Professor” by the University of Adelaide in 2021.

Up to one third of Australians will develop type 2 diabetes in their lifetime. Type 2 diabetes is a leading cause of blindness, amputations, heart disease and kidney disease. Early detection of individuals at risk, and achieving good glycaemic control in those with type 2 diabetes, are key to improving health outcomes and reducing costs. The gut (stomach and intestines) is central to the control of blood glucose and appetite, and therefore represents a logical, yet relatively unexplored, target for novel and improved treatments for type 2 diabetes. A/Prof Wu's program focuses on the pivotal role of the gastrointestinal (GI) tract in glucose metabolism, aiming to understand the pathophysiology, and establish novel strategies to mitigate the risk of type 2 diabetes. This work has achieved international recognition by establishing: (i) key pathological features of GI function responsible for elevated blood glucose in type 2 diabetes, (ii) marked variations in gut-mediated glucose responses along the length of the GI tract, (iii) the predominance of the incretin hormone, glucagon-like peptide-1 (GLP-1), over other gut peptides, in mediating these actions, and (iv) the substantial potential for stimulating endogenous GLP-1 to optimise glycaemic control in patients with type 2 diabetes. A/Prof Wu has co-authored 86 peer-reviewed publications in the top-tier journals, featuring predominantly in the leading journals in the field of diabetes (e.g. Diabetes, Diabetes Care, Diabetes Obes Metab), nutrition (e.g. Am J Clin Nutr) and Endocrinology (e.g. JCEM). 

With ongoing funding support from the NHMRC, Diabetes Australia, The Hospital Research Foundation, Royal Adelaide Hospital Research Committee and The University of Adelaide, his team is determining: (i) the roles of bitter taste sensing pathways in different regions of the gut in the regulation of gastrointestinal function, energy intake and postprandial glycaemia, (ii) the relevance of intestinal bile acids to glucose metabolism and potential of measuring bile acid profiles to predict incident type 2 diabetes, and (iii) the clinical efficacy of combining a dietary strategy with pharmacotherapy on glycaemic control. These studies have a high potential to establish novel, safe and cost-effective strategies to improve the management of type 2 diabetes. In this way, he is also building novel research platforms (i.e. organ-on-a-chip) to markedly enhance the capability for investigating the mechanisms by which intraluminal contents interact with the gut and for screening effective therapeutic regimen for evaluation in clinical trials.

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  • Appointments
    Date Position Institution name
    2021 Associate Professor (Level D) The University of Adelaide
    2020 THRF Mid-Career Fellow (Level C) The University of Adelaide
    2018 - 2020 RAH Florey Fellow (GFS-5) Royal Adelaide Hospital
    2015 - 2017 RAH Mary Overton Early Career Fellow (Level A) The University of Adelaide
    2014 - 2014 Clinical Research Fellow (Level A) The University of Adelaide
    2007 - 2009 Physician Trainee Zhongda Hospital Southeast University
    2006 - 2007 Intern (First Class) Zhongda Hospital Southeast University

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2021 Research Award Emerging Leader Award Faculty of Health and Medical Sciences, The University of Adelaide Australia —
    2020 Fellowship THRF Mid-Career Fellowship The Hospital Research Foundation Australia —
    2019 Award Clinical Science Poster Award Australian Diabetes Society Australia —
    2019 Award Travel Award European Association for the Study of Diabetes Germany —
    2018 Award Northern Communities Health Foundation Derek Frewin Early Career Research Award Northern Communities Health Foundation Australia —
    2018 Fellowship Royal Adelaide Hospital Florey Fellowship Royal Adelaide Hospital Research Committee Australia —
    2016 Award Executive Dean's Award for Research Excellence (Early Career Researcher) The University of Adelaide — —
    2016 Award Travel Award European Association for the Study of Diabetes — €1500
    2016 Award Travel Award University of Adelaide, School of Medicine Australia 2835
    2015 Fellowship Early Career Fellowship Royal Adelaide Hospital Australia —
    2015 Recognition Best Poster Australian Diabetes Society Australia —
    2015 Award Travel Grant University of Adelaide, Discipline of Medicine Australia —
    2014 Research Award University Doctoral Research Medal University of Adelaide Australia —
    2013 Fellowship Travelling Fellowship University of Adelaide, Discipline of Medicine Australia 2600
    2013 Recognition Dean's commendation for thesis excellence University of Adelaide Australia —
    2013 Award Travel Award, Diabetes Congress International Diabetes Federation (IDF) Australia —
    2012 Award Travel Award European Association for the Study of Diabetes — €2000
    2011 Award Travel Award European Association for the Study of Diabetes — €2000
    2011 Fellowship Postgraduate Travelling Fellowship University of Adelaide Australia 1700
    2010 Recognition Best Poster Presentation University of Adelaide, Research Expo Australia —
    2009 Recognition Outstanding Postgraduate in Clinical Medicine Southeast University Australia —
    2009 Scholarship Postgraduate Scholarship China Scholarship Council China —
    2009 Scholarship Postgraduate Supplementary Scholarship Centre of Research Excellence in Translating Nutritional Science to Good Health Australia —
    2007 Scholarship First-class postgraduate scholarship Southeast University China —
    2007 Recognition Outstanding Graduate in Clinical Medicine Southeast University China —
    2006 Recognition 'Excellent Student Researcher' in the Student Research Training Program (SRTP) Southeast University China —
    2004 Scholarship 'Zi-guang' Scholarship Southeast University Australia —

  • Education
    Date Institution name Country Title
    2009 - 2013 University of Adelaide Australia Doctor of Philosophy
    2007 - 2009 Southeast University China Master of Clinical Medicine
    2002 - 2007 Southeast University China Bachelor of Clinical Medicine

  • Research Interests
    Clinical Trials Endocrinology & Metabolism Medical Biochemistry: Proteins and Peptides Medical Physiology Nutrition and Metabolic Health Translational Health Outcomes
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  • Journals
    Year Citation
    2021 Qiu, S., Cai, X., Jia, L., Sun, Z., Wu, T., Wendt, J., . . . Schumann, U. (2021). Does objectively-measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis.. Eur Heart J Qual Care Clin Outcomes, 7(5), 496-504.
    DOI Europe PMC1
    2021 Xie, C., Huang, W., Wang, X., Trahair, L. G., Pham, H. T., Marathe, C. S., . . . Wu, T. (2021). Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink. Diabetes Research and Clinical Practice, 171, 1-8.
    DOI Scopus1 WoS1
    2021 Horowitz, M., Wu, T., Rayner, C. K., Marathe, C. S., & Jones, K. L. (2021). Spontaneous or deliberate: effects of acute variations in glycemia on gastric emptying in type 1 diabetes. Diabetes Care, 44(2), 316-318.
    DOI
    2021 Rayner, C. K., Watson, L. E., Phillips, L. K., Lange, K., Bound, M. J., Grivell, J., . . . Natali, A. (2021). Erratum to: Effects of sustained treatment with lixisenatide on gastric emptying and postprandial glucose metabolism in type 2 diabetes: A randomized controlled trial (Diabetes Care 2020, 43, 1813–1821). Diabetes Care, 44(1), 297.
    DOI
    2021 Xie, C., Huang, W., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021). Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease. Nutrients, 13(4), 1-16.
    DOI Scopus3 WoS4 Europe PMC2
    2021 Sang, M., Wu, T., & Sun, Z. (2021). Pathogenesis and clinical management of diabetes-related gastrointestinal symptoms. Chinese Journal of Diabetes Mellitus, 13(5), 513-516.
    DOI
    2021 Horowitz, M., Rayner, C. K., Marathe, C. S., Wu, T., Umapathysivam, M., & Jones, K. L. (2021). Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism, 23(10), [1]-[3].
    DOI Scopus1 WoS1
    2021 Qiu, S., Cai, X., Sun, Z., Wu, T., & Schumann, U. (2021). Is estimated cardiorespiratory fitness an effective predictor for cardiovascular and all-cause mortality? A meta-analysis. Atherosclerosis, 330, 22-28.
    DOI
    2021 Qiu, S., Cai, X., Yuan, Y., Xie, B., Sun, Z., & Wu, T. (2021). Changes in creatinine-to-cystatin C ratio over 4 years, risk of diabetes, and cardiometabolic control: The China Health and Retirement Longitudinal Study. Journal of Diabetes, 9 pages.
    DOI
    2021 Borg, M. J., Xie, C., Rayner, C. K., Horowitz, M., Jones, K. L., & Wu, T. (2021). Potential for gut peptide‐based therapy in postprandial hypotension. Nutrients, 13(8), 2826-1-2826-14.
    DOI
    2021 Dong, S., Qian, L., Cheng, Z., Chen, C., Wang, K., Hu, S., . . . Wu, T. (2021). Lactate and Myocadiac Energy Metabolism.. Frontiers in physiology, 12, 1-12.
    DOI
    2020 Marathe, C. S., Jones, K. L., Wu, T., Rayner, C. K., & Horowitz, M. (2020). Gastrointestinal autonomic neuropathy in diabetes. Autonomic Neuroscience: Basic and Clinical, 229, 1-9.
    DOI Scopus3 WoS2 Europe PMC1
    2020 Rayner, C. K., Wu, T., Aroda, V. R., Whittington, C., Kanters, S., Guyot, P., . . . Horowitz, M. (2020). Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus GLP-1 RAs in people with type 2 diabetes mellitus: a network meta-analysis.. Diabetes Obes Metab, 23(1), 136-146.
    DOI Scopus4 WoS4 Europe PMC5
    2020 Borg, M. J., Rayner, C. K., Jones, K. L., Horowitz, M., Xie, C., & Wu, T. (2020). Gastrointestinal mechanisms underlying the cardiovascular effect of metformin. Pharmaceuticals, 13(11), 1-14.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Wu, T., Rayner, C. K., Jones, K. L., Xie, C., Marathe, C., & Horowitz, M. (2020). Role of intestinal glucose absorption in glucose tolerance. Current Opinion in Pharmacology, 55, 116-124.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Xie, C., Wang, X., Jones, K. L., Horowitz, M., Sun, Z., Little, T. J., . . . Wu, T. (2020). Comparative effects of intraduodenal glucose and fat infusion on blood pressure and heart rate in type 2 diabetes. Frontiers in Nutrition, 7, 1-6.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Sansome, D. J., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2020). Statins and glycaemic control in type 2 diabetes: Are bile acids relevant?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 86(12), 2 pages.
    DOI
    2020 Jalleh, R., Pham, H., Marathe, C. S., Wu, T., Buttfield, M. D., Hatzinikolas, S., . . . Jones, K. L. (2020). Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution.. Nutrients, 12(7), 1-8.
    DOI Scopus4 WoS4 Europe PMC3
    2020 Xu, X., Wang, X., Sun, Z., & Wu, T. (2020). Relationship between gastric emptying rate and glucose regulation and related glucose lowering strategy. Chinese Journal of Diabetes Mellitus, 12(5), 336-339.
    DOI
    2020 Huang, W., Xie, C., Young, R. L., Zhao, J., Ebendorff-Heidepriem, H., Jones, K. L., . . . Wu, T. (2020). Development of innovative tools for investigation of nutrient-gut interaction. World Journal of Gastroenterology, 26(25), 3562-3576.
    DOI
    2020 Horowitz, M., Rayner, C. K., Marathe, C. S., Wu, T., & Jones, K. L. (2020). Glucagon‐like peptide‐1 receptor agonists and the appropriate measurement of gastric emptying. Diabetes, Obesity and Metabolism, 22(12), 2504-2506.
    DOI Scopus7 WoS7 Europe PMC3
    2020 Xie, C., Jones, K. L., Rayner, C. K., & Wu, T. (2020). Enteroendocrine hormone secretion and metabolic control: importance of the region of the gut stimulation. Pharmaceutics, 12(9), 1-23.
    DOI Scopus6 WoS6 Europe PMC2
    2020 Qiu, S., Cai, X., Wu, T., Sun, Z., Guo, H., Kirsten, J., . . . Schumann, U. (2020). Objectively-Measured Light-Intensity Physical Activity and Risk of Cancer Mortality: A Meta-analysis of Prospective Cohort Studies.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(5), 1067-1073.
    DOI Scopus2 WoS1 Europe PMC2
    2020 Rayner, C. K., Watson, L. E., Phillips, L. K., Lange, K., Bound, M. J., Grivell, J., . . . Natali, A. (2020). Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial.. Diabetes Care, 43(8), 1813-1821.
    DOI Scopus6 WoS6 Europe PMC1
    2020 Zhang, X., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2020). Effects of proximal and distal enteral glucose infusion on cardiovascular response in health and type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 105(8), 2877-2884.
    DOI Scopus3 WoS3 Europe PMC1
    2020 Wang, X., Xie, C., Sun, Z., & Wu, T. (2020). Role of intestinal bile acids in the regulation of metabolic homeostasis in humans. Chinese Journal of Diabetes Mellitus, 12(4), 272-274.
    DOI
    2020 Wang, X., Xie, C., Marathe, C. S., Malbert, C. -H., Horowitz, M., Jones, K. L., . . . Wu, T. (2020). Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes.. Diabetes research and clinical practice, 159, 107951.
    DOI Scopus3 WoS3 Europe PMC1
    2020 Marathe, C. S., Pham, H., Marathe, J. A., Trahair, L. G., Huynh, L., Wu, T., . . . Jones, K. L. (2020). The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance.. Acta Diabetol, 57(5), 583-587.
    DOI
    2020 Jones, K. L., Huynh, L. Q., Hatzinikolas, S., Rigda, R. S., Phillips, L. K., Pham, H. T., . . . Horowitz, M. (2020). Exenatide once weekly slows gastric emptying of solids and liquids in healthy, overweight, subjects under steady-state concentrations. Diabetes, Obesity and Metabolism, 22(5), 788-797.
    DOI Scopus13 WoS13 Europe PMC5
    2020 Huang, W., Wu, T., Shallan, A., Kostecki, R., Rayner, C. K., Priest, C., . . . Zhao, J. (2020). A multiplexed microfluidic platform towards interrogating endocrine function: simultaneous sensing of extracellular Ca²⁺ and hormone. ACS Sensors, 5(2), 490-499.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Sansome, D. J., Xie, C., Veedfald, S., Horowitz, M., Rayner, C. K., & Wu, T. (2020). Mechanism of glucose-lowering by metformin in type 2 diabetes: role of bile acids. Diabetes, Obesity and Metabolism, 22(2), 141-148.
    DOI Scopus20 WoS16 Europe PMC7
    2020 Xie, C., Wang, X., Jones, K. L., Horowitz, M., Sun, Z., Little, T. J., . . . Wu, T. (2020). Role of endogenous glucagon-like peptide-1 enhanced by vildagliptin in the glycaemic and energy expenditure responses to intraduodenal fat infusion in type 2 diabetes. Diabetes, obesity & metabolism, 22(3), 383-392.
    DOI Scopus5 WoS4 Europe PMC2
    2020 Stevens, J., Buttfield, M., Wu, T., Hatzinikolas, S., Pham, H., Lange, K., . . . Jones, K. (2020). Effects of sitagliptin on gastric emptying of, and the glycaemic and blood pressure responses to, a carbohydrate meal in type 2 diabetes. Diabetes, Obesity and Metabolism, 22(1), 51-58.
    DOI Scopus8 WoS8 Europe PMC5
    2019 Borg, M. J., Bound, M., Grivell, J., Sun, Z., Jones, K. L., Horowitz, M., . . . Wu, T. (2019). Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon-like peptide-1, and gastric emptying after oral glucose, in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 640-647.
    DOI Scopus17 WoS17 Europe PMC6
    2019 Watson, L., Phillips, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2019). Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clinical Nutrition, 38(6), 2827-2832.
    DOI Scopus10 WoS8 Europe PMC6
    2019 Jones, K. L., Rigda, R. S., Buttfield, M. D. M., Hatzinikolas, S., Pham, H. T., Marathe, C. S., . . . Horowitz, M. (2019). Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycaemia in healthy people and people with type 2 diabetes. Diabetes, Obesity and Metabolism, 21(5), 1158-1167.
    DOI Scopus22 WoS19 Europe PMC7
    2019 Borg, M. J., Jones, K. L., Sun, Z., Horowitz, M., Rayner, C. K., & Wu, T. (2019). Metformin attenuates the postprandial fall in blood pressure in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(5), 1251-1254.
    DOI Scopus6 WoS7 Europe PMC5
    2019 Zhang, X., Young, R. L., Bound, M., Hu, S., Jones, K. L., Horowitz, M., . . . Wu, T. (2019). Comparative effects of proximal and distal small intestinal glucose exposure on glycemia, incretin hormone secretion, and the incretin effect in health and type 2 diabetes. Diabetes Care, 42(4), 520-528.
    DOI Scopus21 WoS18 Europe PMC12
    2019 Pham, H., Holen, I. S., Phillips, L. K., Hatzinikolas, S., Huynh, L. Q., Wu, T., . . . Jones, K. L. (2019). The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects.. Nutrients, 11(11), 13 pages.
    DOI Scopus3 WoS3
    2019 Watson, L. E., Phillips, L. K., Wu, T., Bound, M. J., Jones, K. L., Horowitz, M., & Rayner, C. K. (2019). Longitudinal evaluation of gastric emptying in type 2 diabetes. Diabetes Research and Clinical Practice, 154, 27-34.
    DOI Scopus5 WoS4
    2019 Pham, H., Marathe, C. S., Phillips, L. K., Trahair, L. G., Hatzinikolas, S., Huynh, L., . . . Jones, K. L. (2019). Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP in healthy older subjects.. The Journal of clinical endocrinology and metabolism, 1054(12), 6201-6206.
    DOI Scopus3 WoS3 Europe PMC2
    2019 Shi, R., Wang, Y., An, X., Ma, J., Wu, T., Yu, X., . . . Sun, Z. (2019). Efficacy of co-administration of Liuwei Dihuang Pills and Ginkgo biloba Tablets on albuminuria in type 2 diabetes: A 24-month, multicenter, double-blind, placebo-controlled, randomized clinical trial. Frontiers in Endocrinology, 10(FEB), 7 pages.
    DOI Scopus7 WoS8 Europe PMC7
    2019 Watson, L. E., Xie, C., Wang, X., Li, Z., Phillips, L. K., Sun, Z., . . . Wu, T. (2019). Gastric emptying in patients with well-controlled type 2 diabetes compared with young and older control subjects without diabetes. Journal of Clinical Endocrinology and Metabolism, 104(8), 3311-3319.
    DOI Scopus22 WoS18 Europe PMC6
    2019 Bitarafan, V., Fitzgerald, P. C. E., Little, T. J., Meyerhof, W., Wu, T., Horowitz, M., & Feinle-Bisset, C. (2019). Effects of intraduodenal infusion of the bitter tastant, quinine, on antropyloroduodenal motility, plasma cholecystokinin, and energy intake in healthy men. Journal of Neurogastroenterology and Motility, 25(3), 413-422.
    DOI Scopus7 WoS8 Europe PMC3
    2019 Watson, L. E., Phillips, L., Wu, T., Bound, M., Checklin, H. L., Grivell, J., . . . Rayner, C. (2019). A whey/guar “preload” improves postprandial glycaemia and glycated haemoglobin levels in type 2 diabetes: a 12-week, single-blind, randomized, placebo-controlled trial. Diabetes, Obesity and Metabolism, 21(4), 930-938.
    DOI Scopus14 WoS15 Europe PMC10
    2019 Bitarafan, V., Fitzgerald, P. C., Little, T. J., Meyerhof, W., Jones, K. L., Wu, T., . . . Feinle-Bisset, C. (2019). Intragastric administration of the bitter tastant, quinine, lowers the glycemic response to a nutrient drink without slowing gastric emptying, in healthy men.. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 318(2), R263-R273.
    DOI Scopus10 WoS12 Europe PMC5
    2019 Pham, H., Phillips, L., Marathe, C., Trahair, L., Hatzinikolas, S., Huynh, L., . . . Jones, K. (2019). Longitudinal changes in fasting and glucose-stimulated GIP and GLP-1 in healthy older subjects. DIABETOLOGIA, 62, S128-S129.
    2018 Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018). Gut mechanisms linking intestinal sweet sensing to glycemic control. Frontiers in Endocrinology, 9, 741-1-741-11.
    DOI WoS14 Europe PMC5
    2018 Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J. F., . . . Rayner, C. K. (2018). Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men. Journal of Clinical Endocrinology and Metabolism, 103(12), 4409-4418.
    DOI Scopus11 WoS12 Europe PMC8
    2018 Xie, C., Wang, X., Young, R. L., Horowitz, M., Rayner, C. K., & Wu, T. (2018). Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control. Frontiers in Endocrinology, 9, 576-1-576-10.
    DOI Scopus27 WoS25 Europe PMC10
    2018 Wu, T., Rayner, C. K., Marathe, C. S., Jones, K. L., & Horowitz, M. (2018). Glucagon receptor signalling–backwards and forwards. Expert Opinion on Investigational Drugs, 27(2), 135-138.
    DOI Scopus5 WoS4
    2018 Trahair, L., Wu, T., Feinle-Bisset, C., Marathe, C., Rayner, C., Horowitz, M., & Jones, K. (2018). Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects. Physiological Reports, 6(4), e13610-1-e13610-8.
    DOI Europe PMC1
    2018 Wu, T., Marathe, C. S., Horowitz, M., Jones, K. L., & Rayner, C. K. (2018). Comment on Russell-Jones et al. diabetes care 2017;40:943-950. Comment on bowering et al. diabetes care 2017;40:951-957. Diabetes Care, 41(3), e27-e28.
    DOI Scopus1 WoS1
    2018 Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889.
    DOI Scopus32 WoS30 Europe PMC15
    2018 Marathe, C., Rayner, C., Wu, T., Jones, K., & Horowitz, M. (2018). Gastric emptying and the personalized management of type 1 diabetes. The Journal of Clinical Endocrinology and Metabolism, 103(9), 3503-3506.
    DOI Scopus4 WoS3 Europe PMC2
    2018 Pham, H., Stevens, J., Rigda, R., Phillips, L., Wu, T., Hausken, T., . . . Jones, K. (2018). Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects. American Journal of Clinical Nutrition, 108(1), 156-162.
    DOI Scopus3 WoS3 Europe PMC3
    2017 Rayner, C., Jones, K., Wu, T., & Horowitz, M. (2017). Gut feelings about diabetes and GLP-1 receptor agonists: lessons to be learnt from studies in functional gastrointestinal disorders. Diabetes, Obesity and Metabolism, 19(3), 309-312.
    DOI Scopus8 WoS8 Europe PMC5
    2017 Thazhath, S., Marathe, C. S., Wu, T., Chang, J., Khoo, J., Kuo, P., . . . Rayner, C. K. (2017). Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes. Diabetes and Vascular Disease Research, 14(1), 59-63.
    DOI Scopus11 WoS12 Europe PMC8
    2017 Wu, T., Horowitz, M., & Rayner, C. K. (2017). New insights into the anti-diabetic actions of metformin: from the liver to the gut. Expert Review of Gastroenterology and Hepatology, 11(2), 157-166.
    DOI Scopus26 WoS24 Europe PMC11
    2017 Wu, T., Trahair, L., Little, T., Bound, M., Zhang, X., Wu, H., . . . Jones, K. (2017). Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes.. Diabetes Care, 40(5), 702-705.
    DOI Scopus10 WoS11 Europe PMC5
    2017 Wu, T., Rayner, C., Watson, L., Jones, K., Horowitz, M., & Little, T. (2017). Comparative effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males. Peptides, 95, 124-127.
    DOI Scopus12 WoS12 Europe PMC7
    2017 Wu, T., Xie, C., Wu, H., Jones, K., Horowitz, M., & Rayner, C. (2017). Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes, Obesity and Metabolism, 19(2), 290-293.
    DOI Scopus31 WoS30 Europe PMC21
    2016 Wu, T., Rayner, C., & Horowitz, M. (2016). Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control. Biomarkers in Medicine, 10(11), 1167-1179.
    DOI Scopus12 WoS11 Europe PMC6
    2016 Rigda, R., Trahair, L., Little, T., Wu, T., Standfield, S., Feinle-Bisset, C., . . . Jones, K. (2016). Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects. Peptides, 86, 126-132.
    DOI Scopus1 WoS1 Europe PMC2
    2016 Thazhath, S., Marathe, C., Wu, T., Chang, J., Khoo, J., Kuo, P., . . . Rayner, C. (2016). The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal motility, flow, transit, and absorption of glucose in healthy subjects and patients with type 2 diabetes: a randomized controlled trial. Diabetes, 65(1), 269-275.
    DOI Scopus36 WoS37 Europe PMC25
    2016 Zhang, X., Liu, T., Wang, Y., Zhong, M., Zhang, G., Liu, S., . . . Hu, S. (2016). Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats. Obesity Surgery, 26(7), 1565-1575.
    DOI Scopus8 WoS6 Europe PMC5
    2016 Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K., . . . Rayner, C. (2016). Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. American Journal of Clinical Nutrition, 103(1), 66-70.
    DOI Scopus53 WoS53 Europe PMC29
    2016 Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K., . . . Rayner, C. (2016). Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: a randomised controlled trial. Nutrition, 32(5), 553-559.
    DOI Scopus6 WoS6 Europe PMC4
    2016 Wu, T., Little, T., Bound, M., Borg, M., Zhang, X., Deacon, C., . . . Rayner, C. (2016). A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes. Diabetes Care, 39(4), 511-517.
    DOI Scopus50 WoS49 Europe PMC30
    2016 Horowitz, M., Wu, T., Deane, A. M., Jones, K. L., & Rayner, C. K. (2016). DPP-4 inhibition and the known unknown. Diabetes, 65(8), 2124-2126.
    DOI Scopus4 WoS4 Europe PMC3
    2016 Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, C., . . . Rayner, C. (2016). Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 101(12), 4769-4778.
    DOI Scopus11 WoS10 Europe PMC3
    2016 Chen, C., Hu, B., Wu, T., Zhang, Y., Xu, Y., Feng, Y., & Jiang, H. (2016). Bile acid profiles in diabetic (db/db) mice and their wild type littermates. Journal of Pharmaceutical and Biomedical Analysis, 131, 473-481.
    DOI Scopus10 WoS8 Europe PMC6
    2015 Yang, B., Lu, Y., He, J., Wu, T., Xie, Z., Lei, C., . . . Sun, Z. (2015). Performance of fasting plasma glucose and postprandial urine glucose in screening for diabetes in Chinese high‑risk population. Chinese Medical Journal, 128(24), 3270-3275.
    DOI Scopus5 WoS5 Europe PMC3
    2015 Wu, T., Thazhath, S., Marathe, C., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2015). Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition and Diabetes, 5(5), e156-1-e156-4.
    DOI Scopus21 WoS32 Europe PMC9
    2015 Mignone, L., Wu, T., Horowitz, M., & Rayner, C. (2015). Whey protein: The "whey" forward for treatment of type 2 diabetes?. World Journal of Diabetes, 6(14), 1274-1284.
    DOI Scopus9 Europe PMC20
    2015 Wu, T., Trahair, L., Bound, M., Deacon, C., Horowitz, M., Rayner, C., & Jones, K. (2015). Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?. Diabetic Medicine, 32(5), 595-600.
    DOI Scopus5 WoS5 Europe PMC2
    2015 Okosun, I., Seale, J., & Lyn, R. (2015). Commingling effect of gynoid and android fat patterns on cardiometabolic dysregulation in normal weight American adults.. Nutrition & diabetes, 5(5), 1-8.
    DOI Europe PMC22
    2014 Thazhath, S., Wu, T., Bound, M., Checklin, H., Jones, K., Willoughby, S., . . . Rayner, C. (2014). Changes in meal composition and duration affect postprandial endothelial function in healthy humans. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(12), G1191-G1197.
    DOI Scopus8 WoS9 Europe PMC6
    2014 Wu, T., Thazhath, S., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Diabetes Research and Clinical Practice, 106(1), e3-e6.
    DOI Scopus43 WoS40 Europe PMC30
    2014 Wu, T., Ma, J., Bound, M., Checklin, H., Deacon, C., Jones, K., . . . Rayner, C. (2014). Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin. Diabetes, 63(8), 2776-2787.
    DOI Scopus33 WoS33 Europe PMC20
    2014 Thazhath, S., Wu, T., Young, R., Horowitz, M., & Rayner, C. (2014). Glucose absorption in small intestinal diseases. Expert Review of Gastroenterology and Hepatology, 8(3), 301-312.
    DOI Scopus13 WoS11 Europe PMC6
    2014 Li, F., Chen, B., Li, L., Zha, M., Zhou, S., Wu, T., . . . Sun, Z. (2014). INS-1 cells inhibit the production of extracellular matrix from pancreatic stellate cells. Journal of Molecular Histology, 45(3), 321-327.
    DOI Scopus4 WoS5 Europe PMC3
    2013 Wu, T., Bound, M., Standfield, S., Jones, K., Horowitz, M., & Rayner, C. (2013). Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans. Journal of Clinical Endocrinology and Metabolism, 98(4), 718-722.
    DOI Scopus59 WoS52 Europe PMC40
    2013 Wu, T., Bound, M., Standfield, S., Gedulin, B., Jones, K., Horowitz, M., & Rayner, C. (2013). Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes Obesity & Metabolism, 15(5), 474-477.
    DOI Scopus83 WoS82 Europe PMC58
    2013 Wu, T., Bound, M., Standfield, S., Bellon, M., Young, R., Jones, K., . . . Rayner, C. (2013). Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care, 36(12), e202-e203.
    DOI Scopus40 WoS43 Europe PMC25
    2013 Wu, T., Rayner, C., Young, R., & Horowitz, M. (2013). Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology, 13(6), 928-934.
    DOI Scopus43 WoS42 Europe PMC27
    2013 Chang, J., Wu, T., Greenfield, J., Samocha-Bonet, D., Horowitz, M., & Rayner, C. (2013). Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes. Diabetes Care, 36(8), 2262-2265.
    DOI Scopus30 WoS32 Europe PMC21
    2013 Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541.
    DOI Scopus72 WoS67 Europe PMC48
    2013 Wu, T., Bound, M., Zhao, R., Standfield, S., Bellon, M., Jones, K., . . . Rayner, C. (2013). Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care, 36(7), 1913-1918.
    DOI Scopus37 WoS37 Europe PMC27
    2012 Wu, T., Zhao, R., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. American Journal of Clinical Nutrition, 95(1), 78-83.
    DOI Scopus107 WoS103 Europe PMC70
    2010 Wu, T., Rayner, C., Jones, K., & Horowitz, M. (2010). Dietary effects on incretin hormone secretion. Unknown Journal, 84, 81-110.
    DOI Scopus39 WoS36 Europe PMC26

  • Book Chapters
    Year Citation
    2017 Watson, L., Wu, T., Horowitz, M., & Rayner, C. (2017). Whey Protein and Diabetes. In R. Watson, R. Collier, & V. Preedy (Eds.), Dairy in Human Health and Disease across the Lifespan (pp. 197-209). United Kingdom: Academic Press.
    DOI Scopus2
    2016 Wu, T., Rayner, C., & Horowitz, M. (2016). Incretins. In S. Herzig (Ed.), Metabolic Control (Vol. 233, pp. 137-171). Switzerland: Springer.
    DOI Scopus40 Europe PMC20
    2010 Wu, T., Rayner, C. K., Jones, K., & Horowitz, M. (2010). Dietary Effects on Incretin Hormone Secretion. In Incretins and Insulin Secretion (pp. 81-110). Elsevier.
    DOI

  • Conference Papers
    Year Citation
    2018 Borg, M. J., Rayner, C. K., Horowitz, M., Jones, K. L., & Wu, T. (2018). Metformin attenuates the fall in postprandial blood pressure and slows gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S112). Berlin, GERMANY: SPRINGER.
    2018 Rayner, C. K., Watson, L. E., Phillips, L. K., Bound, M. J., Grivell, J., Wu, T., . . . Natali, A. (2018). Effects of sustained treatment with lixisenatide on gastric emptying and glucose metabolism in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S386-S387). Berlin, GERMANY: SPRINGER.
    2018 Trahair, L., Nauck, M., Wu, T., Buttfield, M., Stevens, J., Hatzinikolas, S., . . . Jones, K. (2018). Measurement of gastric emptying using scintigraphy and a C-13-octanoic acid breath test with Wagner-Nelson analysis in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S338-S339). Berlin, GERMANY: SPRINGER.
    WoS2
    2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz., Jones, K. L., & Rayner, C. K. (2015). Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes. In Diabetes. Adelaide.
    2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz, M., Jones, K. L., & Rayner, C. K. (2015). Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes. In Diabetes. Adelaide.
    2012 Bound, M., Wu, T., Gedulin, B., Horowitz, M., & Rayner, C. (2012). Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans. In Diabetologia Vol. 55 (pp. S338). Germany: Springer.
    DOI
    2012 Zhao, R., Wu, T., Jones, K., Horowitz, M., & Rayner, C. (2012). Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes. In Journal of Gastroenterology and Hepatology Vol. 27 (pp. 148-149). Australia: Wiley-Blackwell.
    DOI
    2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER.
    2010 Ma, J., Wu, T., Checklin, H., Wishart, J., Stevens, J., Jones, K., . . . Rayner, C. (2010). Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A114-A115). WILEY-BLACKWELL PUBLISHING, INC.
    2010 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2010). Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A105). WILEY-BLACKWELL PUBLISHING, INC.

  • Conference Items
    Year Citation
    2020 Wang, X., Chen, C., Xie, C., Horowitz, M., Jones, K., Rayner, C., . . . Wu, T. (2020). Serum bile acids after an oral glucose load in Chinese healthy individuals and patients with type 2 diabetes: relationships with glycaemia. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Xie, C., Wang, X., Bound, M. J., Young, R. L., Jones, K. L., Horowitz, M., . . . Wu, T. (2020). Bitter taste signalling modulates bile acid-induced PYY, but not GLP-1 secretion in healthy humans. Poster session presented at the meeting of Abstracts of the 56th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Virtual Online: Springer-Verlag.
    DOI
    2020 Wu, T., Xie, C., Wang, X., Bound, M., Grivell, J., Jones, K., . . . Rayner, C. (2020). Role of endogenous glucagon-like peptide-1 in the serum triglyceride response to intraduodenal fat infusion in type 2 diabetic patients on vildagliptin. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Sansome, D., Veedfald, S., Xie, C., Bound, M., Grivell, J., Jones, K., . . . Wu, T. (2020). Role of bile acids on glucose-lowering by metformin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Huynh, L., Ng, S., Xie, D., Hargreaves, M., Murthy, T. A., Wu, T., . . . Marathe, C. (2020). Diabetes distress is associated with gastrointestinal symptoms in type 1 diabetes. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Bizzotto, R., Rayner, C. K., Watson, L. E., Phillips, L. K., Lange, K., Bound, M. J., . . . Mari, A. (2020). Comparison of paracetamol absorption and gastric emptying measured by scintigraphy in relation to rate of appearance of oral glucose and postprandial glycaemia. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Wu, T., Wang, X., Xie, C., Marathe, C. S., Malbert, C. -H., Horowitz, M., . . . Sun, Z. (2020). Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
    2019 Jalleh, R., Pham, H., Marathe, C., Wu, T., Buttfield, M., Hatzinikolas, S., . . . Jones, K. (2019). Acute effects of lixisenatide on intragastric meal distribution: impact on energy intake. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Jones, K., Huynh, L., Hatzinikolas, S., Rigda, R., Phillips, L., Pham, H., . . . Horowitz, M. (2019). Effect of exenatide once-weekly (QW) on gastric emptying in health: impact on glycaemia and glucose absorption. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    WoS1
    2019 Huynh, L., Pham, H., Holen, I., Hatzinikolas, S., Phillips, L., Wu, T., . . . Jones, K. (2019). Effects of a guar/whey preload on gastric emptying and glycaemic responses to oral glucose in healthy older people. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Xie, C., Wang, X., Bound, M., Grivell, J., Jones, K., Horowitz, M., . . . Wu, T. (2019). Roles of endogenous GLP-1 in the glycaemic and energy expenditure responses to fat in type 2 diabetes studied using vildagliptin and exendin(9-39). Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Marathe, C., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Wu, T., . . . Jones, K. (2019). Acute administration of lixisenatide diminishes the insulin secretory response to oral glucose by slowing gastric emptying. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Marathe, J., Pham, H., Trahair, L., Huynh, L., Wu, T., Rayner, C., . . . Marathe, C. (2019). Relationships between GIP and GLP-1 secretion in people with normal or impaired glucose tolerance. Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Horowitz, M., Xie, C., Wang, X., Bound, M. J., Grivell, J., Jones, K. L., . . . Wu, T. (2019). Comparative effects of intraduodenal glucose and fat on blood pressure and heart rate in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Barcelona, SPAIN: Springer-Verlag.
    DOI
    2019 Wu, T., Zhang, X., Horowitz, M., Jones, K., & Rayner, C. (2019). Comparative effects of proximal and distal small intestinal glucose exposure on blood pressure, heart rate and mesenteric blood flow in health and type 2 diabetes. Poster session presented at the meeting of Diabetologia. Barcelona, Spain: Springer.
    2018 Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J., . . . Rayner, C. (2018). Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
    2018 Wu, T., Borg, M., Jones, K., Horowitz, M., & Rayner, C. (2018). Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and GLP-1, and gastric emptying after oral glucose in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Berlin, GERMANY: SPRINGER.
    2018 Bitarafan, V., Fitzgerald, P., Little, T., Wu, T., Horowitz, M., & Feinle-Bisset, C. (2018). Effects of intraduodenal infusion of the bitter tastant, quinine, on antropyloroduodenal motility, plasma cholecystokinin concentrations and energy intake in humans. Poster session presented at the meeting of Abstracts of the 3rd meeting of the Federation of Neurogastroenterology and Motility (FNM 2018), as published in Neurogastroenterology & Motility. Amsterdam, The Netherlands: Wiley.
    DOI
    2018 Xie, C., Wang, X., Bound, M., Grivell, J., Young, R., Jones, K., . . . Wu, T. (2018). Effects of the bitter taste receptor agonist, denatonium benzoate, on postprandial glycaemia, gastric emptying and energy intake in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI
    2018 Jones, K., Stevens, J., Buttfield, M., Wu, T., Hatzinikolas, S., Pham, H., . . . Horowitz, M. (2018). The reduction in postprandial glucose by sitagliptin is related to the rate of gastric emptying in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Berlin, GERMANY: SPRINGER.
    2018 Young, R., Kreuch, D., Mobegi, F., Leong, L., Schober, G., Isaacs, N., . . . Rogers, G. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI
    2017 Phillips, L., Watson, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2017). Longitudinal evaluation of gastric emptying in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI
    2017 Jones, K., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Marathe, C., . . . Horowitz, M. (2017). Acute effects of lixisenatide on gastric emptying, glycaemia and 'postprandial' blood pressure responses to an oral glucose load in healthy subjects and type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI WoS1
    2017 Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI WoS2
    2017 Rayner, C., Wu, T., Horowitz, M., & Jones, K. (2017). Blockade of glucagon-like peptide-1 receptors by exendin(9-39) attenuates the increase in heart rate during small intestinal glucose infusion in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI WoS1
    2017 Wu, T., Horowitz, M., Jones, K., & Rayner, C. (2017). Endogenous glucagon-like peptide-1 mediates the lowering of glycaemia during small intestinal glucose infusion by bile acids in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI WoS2
    2017 Buttfield, M., Stevens, J., Hatzinikolas, S., Wu, T., Pham, H., Lange, K., . . . Jones, K. (2017). EFFECTS OF SITAGLIPTIN ON GASTRIC EMPTYING OF, AND THE BLOOD PRESSURE RESPONSE TO, A CARBOHYDRATE MEAL IN TYPE 2 DIABETES. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY.
    2016 Chen, C., Hu, B., Wu, T., & Jiang, H. (2016). Targeted metabolomics study on bile acid profiles in db/db mice and their wild type littermates. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER.
    2016 Zhang, X., Bound, M., Standfield, S., Hu, S., Jones, K., Horowitz, M., . . . Wu, T. (2016). Comparative effects of proximal and distal small intestinal glucose on glycaemia, incretin hormone secretion and incretin effect in healthy males. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag.
    DOI WoS2
    2016 Wu, T., Zhang, X., Little, T., Bound, M., Standfield, S., Deacon, C., . . . Rayner, C. (2016). The rate of intraduodenal glucose delivery affects the lowering of blood glucose by vildagliptin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. Munich, GERMANY: SPRINGER.
    2016 Mignone, L., Wu, T., Phillips, L., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2016). A whey/guar "preload" improves postprandial glycaemia and HbA(1c) in type 2 diabetes: a 12-week, single-blind, randomised and placebo controlled trial. Poster session presented at the meeting of Abstracts of the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Munich, GERMANY: Springer-Verlag.
    DOI
    2014 Mignone, L., Wu, T., Bound, M., Jones, K., Horowitz, M., & Rayner, C. (2014). A low-dose whey protein preload slows gastric emptying and improves post-prandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
    2014 Wu, T., Bound, M., Deacon, C., Jones, K., Horowitz, M., & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
    2012 He, J., Sun, Z., Wu, T., Xie, Z., Lu, Y., Lei, C., . . . Zhou, Y. (2012). Screening for diabetes and pre-diabetes with combined use of FPG and quantitative postprandial urine glucose in Chinese high-risk population: a community-based study. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
    2012 Wu, T., Zhao, B., Horowitz, M., Jones, K., & Rayner, C. (2012). Effects of a xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. SPRINGER.
    2012 Young, R., Chia, B., Wu, T., Michael, H., & Rayner, C. (2012). Loss of intestinal sweet taste receptor control in type 2 diabetes: A risk factor for postprandial hyperglycemia?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.

2021 – 22                   Diabetes Australia Project Grant (Y21G-WUTO) ($60,000)

 Project title: More or less? Bile acids and glycaemic control in type 2 diabetes

Tongzhi Wu, Chris Rayner, Richard Young, Karen Jones, Michael Horowitz

2021                           FHMS Emerging Leaders Development Award ($40,000) Tongzhi Wu

 Project title: Application of novel 'organ-on-a-chip' systems in metabolic research

2021                           FHMS Near-Miss Ideas Grant Application Scheme ($36,245)

 Project title: Optimisation of 'intestine-on-a-chip' for investigation of nutrient-gut interaction

Tongzhi Wu, Chris Rayner, Richard Young, Michael Horowitz, Karen Jones, Heike Ebendorff-Heidepriem

2020 – 23                    The Hospital Research Foundation Mid-Career Fellowship ( $480,000) Tongzhi Wu

2020 – 21                    Diabetes Australia Project Grant (Y20G-WUTO) ($60,000)

 Project title: Effects of endogenous bile acids on postprandial glucose metabolism in type 2 diabetes, and the impact of the small intestinal region exposed

Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz

2020 – 21                    Royal Adelaide Hospital Research Committee Clinical Project Grant ($48,286)

Project title: GLP-1 for lowering plasma glucose in type 2 diabetes: A systemic comparison of intravenous and subcutaneous routes

 Chris Rayner, Daniel Quast, Tongzhi Wu

2020 – 21                   Royal Adelaide Hospital Research Committee Clinical Project Grant ($50,000)

Project title: Effects of endogenous bile acids on postprandial glucose metabolism in health, and the impact of the small intestinal region exposed

 Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz

2020  – 21                   Diabetes Australia Project Grant (Y20G-YOUR) ($59,762)

 Project title: Does the gut microbiome link intake of low-calorie sweeteners to impaired blood glucose control?

Richard Young, Geraint Rogers, Chris Rayner, Michael Horowitz, Tongzhi Wu

2019 – 20                    Diabetes Australia Project Grant (Y19G-WUTO) ($60,000)

 Project title: Role of bile acids in glucose-lowering by metformin

 Tongzhi Wu, Chris Rayner, Karen Jones, Michael Horowitz

2019 – 21                    RAH Research Foundation Clinical Project Grant ($49,998)

Project title: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes.

Tongzhi Wu, Liza Phillips, Chris Rayner, Karen Jones, Michael Horowitz

2019                            Diabetes Australia Project Grant (Y19G-JONK) ($59,872)

Project title: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, an oral glucose load in type 2 diabetes.

Karen Jones, Liza Phillips, Tongzhi Wu, Chinmay Marathe, Michael Howoritz, Chris Rayner.

2018 – 21                    NHMRC Project Grant (APP1147333) ($725,276)

Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes. 

CIA: Tongzhi Wu, CIB: Chris Rayner, CIC: Karen Jones, CID: Richard Young, CIE: Christine Feinle-Bisset

2018 – 20                    Royal Adelaide Hospital (RAH) Research Foundation Florey Fellowship ($348,000) Tongzhi Wu

2018 – 19                    Diabetes Australia Millennium Grant ($150,000)

Project title:Do artificial sweeteners affect glycaemic control in T2DM adversely? 

Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu

2018                            RAH Research Foundation Clinical Project Grant ($49,472)

Project title: Role of endogenous glucose-dependent insulinotropic polypeptide in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects.

Karen Jones, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz

2018                            RAH Research Foundation Clinical Project Grant ($49,710)

Project title: Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes.

Richard Young, Nam Nguyen, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, CIE: Michael Horowitz

2017 – 18                    University of Adelaide Early Career Researcher Mentored Project Grant ($14,992)

Project title: Nutrient-gut interactions and glycaemic control in type 2 diabetes. 

Tongzhi Wu

2017 – 18                    Project Development Grant of the NHMRC CRE in Translating Nutritional Science to Good Health ($32,610)

Project title: Stimulating intestinal bitter taste receptors for control of type 2 diabetes

Tongzhi Wu

2017 – 19                    Investigator-initiated study funded by Novartis ($211,106)

Project title: Defining the role of endogenous glucagon-like peptide-1 (GLP-1) in the glycaemic, triglyceride and energy expenditure responses to fat in patients with type 2 diabetes using Galvus (vildagliptin) and the GLP-1 receptor antagonist exendin(9-39)

Tongzhi Wu

2017 – 18                    Diabetes Australia project grant (Y17G-WUTO) ($59,270)

Project title: Gastrointestinal mechanisms of the anti-diabetic effect of metformin. 

Tongzhi Wu,Chris Rayner, Michael Horowitz

2017                            University of Adelaide Research Infrastructure Awards ($26,410)

Project title: LOGIQ eR7 Ultrasound System to measure 2D and Doppler ultrasound in nutrition research. 

Karen Jones, Chris Rayner Christine Feinle-Bisset, Tongzhi Wu, Stijn Soenen

2016 – 17                    RAH Research Foundation Clinical Project Grant ($49,258)

Project title: Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans?

Tongzhi Wu, Chris Rayner

2015 – 17                    RAH Research Committee Early Career Fellowship ($252,000)

Project title: The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes

Tongzhi Wu

2015                            The University of Adelaide Interdisciplinary Seed Funding

Project title: Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cells. Jiangbo Zhao, Tongzhi Wu

2014 – 16                    RAH Research Foundation Clinical Project Grant ($40,000)

Project title: Intestinal sweet taste receptor control of glucose absorption in human health & type 2 diabetes.CIA: Richard Young, Tongzhi Wu, Chris Rayner

2014 – 16                    RAH Research Foundation Clinical Project Grant ($49,700)

Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying.Karen Jones, Tongzhi Wu, Chris Rayner

2014                            Clinical Research Fellowship of NHMRC CRE in Translating Nutritional Science to Good Health($80,571)

Project title: Gastrointestinal function and the management of type 2 diabetes

Tongzhi Wu

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  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Principal Supervisor Human gut-pancreas chip - a novel in vitro model for diabetes study Doctor of Philosophy Doctorate Full Time Mr Weikun Huang
    2017 Co-Supervisor Bitter Taste Control of Blood Glucose Homeostasis Doctor of Philosophy Doctorate Full Time Mr Cong Xie

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2017 - 2019 Co-Supervisor A microfluidic sensing system for simultaneous monitoring of extracellular Ca(II) and insulin secretion Master of Philosophy Master Full Time Mr Weikun Huang

  • Other Supervision Activities
    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2021 - ongoing Principal Supervisor Taste receptor signalling and renal glucose excretion in health and diabetes The University of Adelaide/Southeast University — Doctorate Full Time Ting-ting Li
    2020 - ongoing Principal Supervisor The role of bile acid-gut interaction in glucose homeostasis The University of Adelaide/Southeast University — Doctorate Full Time Chun-jie Xiang
    2019 - ongoing Principal Supervisor Human gut-pancreas chip - a novel in vitro model for diabetes study The University of Adelaide — Higher Doctorate Full Time Weikun Huang
    2019 - ongoing Principal Supervisor Interaction of intestinal bile acids with metformin The University of Adelaide — Honours Full Time Daniel Sansome
    2017 - ongoing Principal Supervisor Effects of nutritive and non-nutritive compounds on gut function, appetite and blood glucose The University of Adelaide — Higher Doctorate Full Time Xuyi Wang
    2017 - 2017 Principal Supervisor Gastrointestinal mechanisms of the anti-diabetic effect of metformin The University of Adelaide — Honours Full Time Malcolm Borg
    2015 - ongoing Principal Supervisor Characterisation of glucose disposal mediated by different gut regions in health and type 2 diabetes The University of Adelaide — Doctorate Full Time Xiang Zhang
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  • Committee Memberships
    Date Role Committee Institution Country
    2019 - ongoing Board Member Chinese Diabetes Society - Translational Research Group Chinese Diabetes Society China
    2015 - ongoing Member Australian Diabetes Society — Australia
    2009 - ongoing Member European Association for the Study of Diabetes — —
  • Position: Associate Professor
  • Phone: 83136535
  • Email: tongzhi.wu@adelaide.edu.au
  • Fax: 8223 3870
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 6
  • Room: 6 061
  • Org Unit: Medical Specialties
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