Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
The gut (stomach and intestines) is central to the control of blood glucose and appetite, and therefore represents a logical, yet relatively unexplored, target for novel and improved treatments for type 2 diabetes mellitus (T2DM) and obesity. Dr Wu's research program utilises mutidisciplinary techniques to provide important insights into how nutrients, and particularly bitter tasting compounds, can intereact with specific diabetes medicines for therapeutic gain.
Dr Tongzhi Wu leads a research team within the NHMRC Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health at the University of Adelaide, to gain an improved understanding on how ingested nutrients interact with the gut in health and disease and whether this can be translated into safe and improved treatments for type 2 diabetes. He is particularly interested in how the gut “tastes” meal contents, especially bitter tasting substances and the mechanisms by which specific anti-diabetic drugs (e.g. metformin, DPP-4 inhibitors) interact with the gut. His research has been funded by the National Health and Medical Research Council (NHMRC), Diabetes Australia, the Royal Adelaide Hospital (RAH) Research Foundation, and the University of Adelaide.
Dr Wu is currently undertaking a number of studies to:
- define the roles of intestinal bitter taste sensing in the regulation of gastrointestinal hormone secretion, energy intake and postprandial glycaemia, and the implications for T2DM therapy; and
- clarify the role of bile acids in the anti-diabetic action of metformin.
Date Position Institution name 2018 Adjunct Senior Fellow University of Adelaide, Adelaide 2018 - 2020 Royal Adelaide Hospital Florey Fellow Royal Adelaide Hospital, Adelaide 2015 - 2017 Royal Adelaide Hospital Mary Overton Fellow University of Adelaide 2014 - 2014 NHMRC Clinical Research Fellow University of Adelaide, Adelaide 2007 - 2009 Physician Trainee Zhongda Hospital Southeast University 2006 - 2007 Intern (First Class) Zhongda Hospital Southeast University
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award Northern Communities Health Foundation Derek Frewin Early Career Research Award Northern Communities Health Foundation Australia — 2016 Award Executive Dean's Award for Research Excellence (Early Career Researcher) The University of Adelaide — — 2016 Award Travel Award European Association for the Study of Diabetes — €1500 2016 Award Travel Award University of Adelaide, School of Medicine Australia 2835 2015 Fellowship Early Career Fellowship Royal Adelaide Hospital Australia — 2015 Recognition Best Poster Australian Diabetes Society Australia — 2015 Award Travel Grant University of Adelaide, Discipline of Medicine Australia — 2014 Research Award University Doctoral Research Medal University of Adelaide Australia — 2013 Recognition Dean's commendation for thesis excellence University of Adelaide Australia — 2013 Award Travel Award, Diabetes Congress International Diabetes Federation (IDF) Australia — 2013 Fellowship Travelling Fellowship University of Adelaide, Discipline of Medicine Australia 2600 2012 Award Travel Award European Association for the Study of Diabetes — €2000 2011 Award Travel Award European Association for the Study of Diabetes — €2000 2011 Fellowship Postgraduate Travelling Fellowship University of Adelaide Australia 1700 2010 Recognition Best Poster Presentation University of Adelaide, Research Expo Australia — 2009 Recognition Outstanding Postgraduate in Clinical Medicine Southeast University Australia — 2009 Scholarship Postgraduate Scholarship China Scholarship Council China — 2009 Scholarship Postgraduate Supplementary Scholarship Centre of Research Excellence in Translating Nutritional Science to Good Health Australia — 2007 Scholarship First-class postgraduate scholarship Southeast University China — 2007 Recognition Outstanding Graduate in Clinical Medicine Southeast University China — 2006 Recognition 'Excellent Student Researcher' in the Student Research Training Program (SRTP) Southeast University China — 2004 Scholarship 'Zi-guang' Scholarship Southeast University Australia —
Date Institution name Country Title 2009 - 2013 University of Adelaide Australia Doctor of Philosophy 2007 - 2009 Southeast University China Master of Clinical Medicine 2002 - 2007 Southeast University China Bachelor of Clinical Medicine
Year Citation 2017 Watson, L., Wu, T., Horowitz, M., & Rayner, C. (2017). Whey Protein and Diabetes. In Dairy in Human Health and Disease across the Lifespan (pp. 197-209).
2016 Wu, T., Rayner, C. K., & Horowitz, M. (2016). Incretins. In S. Herzig (Ed.), Metabolic Control (Vol. 233, pp. 137-171). Switzerland: Springer.
DOI Scopus23 Europe PMC14
Year Citation 2018 Bitarafan, V., Fitzgerald, P., Little, T., Wu, T., Horowitz, M., & Feinle-Bisset, C. (2018). Effects of intraduodenal infusion of the bitter tastant, quinine, on antropyloroduodenal motility, plasma cholecystokinin concentrations and energy intake in humans. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). Korea (South): WILEY.
2018 Borg, M., Rayner, C., Horowitz, M., Jones, K., & Wu, T. (2018). Metformin attenuates the fall in postprandial blood pressure and slows gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S112). Berlin, GERMANY: SPRINGER. 2018 Jones, K., Stevens, J., Buttfield, M., Wu, T., Hatzinikolas, S., Pham, H., . . . Horowitz, M. (2018). The reduction in postprandial glucose by sitagliptin is related to the rate of gastric emptying in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S381). Berlin, GERMANY: SPRINGER. 2018 Trahair, L., Nauck, M., Wu, T., Buttfield, M., Stevens, J., Hatzinikolas, S., . . . Jones, K. (2018). Measurement of gastric emptying using scintigraphy and a C-13-octanoic acid breath test with Wagner-Nelson analysis in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S338-S339). Berlin, GERMANY: SPRINGER. 2018 Rayner, C., Watson, L., Phillips, L., Bound, M., Grivell, J., Wu, T., . . . Natali, A. (2018). Effects of sustained treatment with lixisenatide on gastric emptying and glucose metabolism in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S386-S387). Berlin, GERMANY: SPRINGER. 2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz., Jones, K. L., & Rayner, C. K. (2015). Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes. In Diabetes. Adelaide. 2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz, M., Jones, K. L., & Rayner, C. K. (2015). Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes. In Diabetes. Adelaide. 2012 Bound, M., Wu, T., Gedulin, B., Horowitz, M., & Rayner, C. (2012). Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans. In Diabetologia Vol. 55 (pp. S338). Germany: Springer.
2012 Zhao, R., Wu, T., Jones, K., Horowitz, M., & Rayner, C. (2012). Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes. In Journal of Gastroenterology and Hepatology Vol. 27 (pp. 148-149). Australia: Wiley-Blackwell.
2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. In DIABETOLOGIA Vol. 54 (pp. S330). Lisbon, PORTUGAL: SPRINGER. 2010 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., . . . Rayner, C. (2010). Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A105). WILEY-BLACKWELL PUBLISHING, INC. 2010 Ma, J., Wu, T., Checklin, H., Wishart, J., Stevens, J., Jones, K., . . . Rayner, C. (2010). Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 25 (pp. A114-A115). WILEY-BLACKWELL PUBLISHING, INC.
2019 – 22 NSFC Project Grant (81870561) ( ¥570,000)
Project title: Effects of intestinal bitter taste sensing on gastrointestinal hormone secretion and glycaemic control
Tongzhi Wu, Chris Rayner, Richard Young, Qin Lu, Dong Wang, Xuyi Wang, Juan Chen, Min Cai, Min Ge
2019 Diabetes Australia Project Grant (Y19G-WUTO) ($59,991)
Project title: Role of bile acids in glucose-lowering by metformin
Tongzhi Wu, Chris Rayner, Karen Jones, Michael Horowitz
2018 – 20 NHMRC Project Grant (APP1147333) ($725,276)
Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.
CIA: Tongzhi Wu, CIB: Chris Rayner, CIC: Karen Jones, CID: Richard Young, CIE: Christine Feinle-Bisset
2018 – 20 Royal Adelaide Hospital (RAH) Research Foundation Florey Fellowship ($348,000)
Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.
CIA: Tongzhi Wu
2018 – 19 Diabetes Australia Millennium Grant ($150,000)
Project title:Do artificial sweeteners affect glycaemic control in T2DM adversely?
Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu
2018 RAH Research Foundation Clinical Project Grant ($49,472)
Project title: Role of endogenous glucose-dependent insulinotropic polypeptide in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects.
Karen Jones, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz
2018 RAH Research Foundation Clinical Project Grant ($49,710)
Project title: Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes.
Richard Young, Nam Nguyen, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, CIE: Michael Horowitz
2017 – 18 University of Adelaide Early Career Researcher Mentored Project Grant ($14,992)
Project title: Nutrient-gut interactions and glycaemic control in type 2 diabetes.
2017 – 18 Project Development Grant of the NHMRC CRE in Translating Nutritional Science to Good Health ($32,610)
Project title: Stimulating intestinal bitter taste receptors for control of type 2 diabetes
2017 – 18 Diabetes Australia project grant (Y17G-WUTO) ($59,270)
Project title: Gastrointestinal mechanisms of the anti-diabetic effect of metformin.
Tongzhi Wu,Chris Rayner, Michael Horowitz
2017 University of Adelaide Research Infrastructure Awards ($26,410)
Project title: LOGIQ eR7 Ultrasound System to measure 2D and Doppler ultrasound in nutrition research.
Karen Jones, Chris Rayner Christine Feinle-Bisset, Tongzhi Wu, Stijn Soenen
2016 – 17 RAH Research Foundation Clinical Project Grant ($49,258)
Project title: Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans?
Tongzhi Wu, Chris Rayner
2015 – 17 RAH Research Committee Early Career Fellowship ($252,000)
Project title: The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes
2015 The University of Adelaide Interdisciplinary Seed Funding
Project title: Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cells. Jiangbo Zhao, Tongzhi Wu
2014 – 16 RAH Research Foundation Clinical Project Grant ($40,000)
Project title: Intestinal sweet taste receptor control of glucose absorption in human health & type 2 diabetes.CIA: Richard Young, Tongzhi Wu, Chris Rayner
2014 – 16 RAH Research Foundation Clinical Project Grant ($49,700)
Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying.Karen Jones, Tongzhi Wu, Chris Rayner
2014 Clinical Research Fellowship of NHMRC CRE in Translating Nutritional Science to Good Health($80,571)
Project title: Gastrointestinal function and the management of type 2 diabetes
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 Co-Supervisor Bitter Taste Control of Blood Glucose Homeostasis Doctor of Philosophy Doctorate Full Time Mr Cong Xie 2017 Co-Supervisor The design and establishment of a microfluidic sensing platform for metal ion and hormone Master of Philosophy Master Full Time Mr Weikun Huang
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