Tongzhi Wu

Associate Professor Tongzhi Wu

Ext-Funded Research Fellow (D)

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

A/Prof Wu is an emerging research leader, with a steeply rising trajectory in research on nutrient-gut interactions and type 2 diabetes. He was a top medical graduate (2009) of Southeast University (Nanjing, China), completed a University of Adelaide PhD conferred with a University Doctoral Research Medal (2013), and transformed into a research group leader during his Royal Adelaide Hospital (RAH) Mary Overton Early Career (2015-17) and Flory (2018-20) Fellowships. He was awarded a ‘top-ranked’ Mid-Career Fellowship from The Hospital Research Foundation (THRF) in 2020 and was promoted to “Associate Professor” by the University of Adelaide in 2021.

Type 2 diabetes is now a "global pandemic", and is a leading cause of blindness, amputations, heart disease and kidney disease. Early detection of individuals at risk, and achieving good glycaemic control in those with type 2 diabetes, are key to improving health outcomes and reducing costs. The gut (stomach and intestines) is central to the control of blood glucose and appetite, and therefore represents a logical, yet relatively unexplored, target for novel and improved treatments for type 2 diabetes. A/Prof Wu's program focuses on the pivotal role of the gastrointestinal (GI) tract in glucose metabolism, aiming to understand the pathophysiology, and establish novel strategies to mitigate the risk of type 2 diabetes. This work has achieved international recognition by establishing: (i) key pathological features of GI function responsible for elevated blood glucose in type 2 diabetes, (ii) marked variations in gut-mediated glucose responses along the length of the GI tract, (iii) the predominance of the incretin hormone, glucagon-like peptide-1 (GLP-1), over other gut peptides, in mediating these actions, and (iv) the substantial potential for stimulating endogenous GLP-1 to optimise glycaemic control in patients with type 2 diabetes. A/Prof Wu has co-authored >100 peer-reviewed publications in the top-tier journals, featuring predominantly in the leading journals in the field of diabetes (e.g. Diabetes, Diabetes Care, Diabetes Obes Metab), nutrition (e.g. Am J Clin Nutr) and Endocrinology (e.g. JCEM). 

With ongoing funding support from the NHMRC, Diabetes Australia, The Hospital Research Foundation, Royal Adelaide Hospital Research Committee and The University of Adelaide, his team is determining: (i) the roles of bitter taste sensing pathways in different regions of the gut in the regulation of gastrointestinal function, energy intake and postprandial glycaemia, (ii) the potential of utilising bile acids as a therapy to restore glucose homeostasis and measuring circulating bile acid profiles to predict future risk of type 2 diabetes, and (iii) the clinical efficacy of combining a dietary strategy with pharmacotherapy on glycaemic control. These studies have a high potential to establish novel, safe and cost-effective solutions to type 2 diabetes. In this effort, he has also built novel research platforms (i.e. organ-on-a-chip) in collaboration with Prof Heike Ebendorff-Heidepriem and Dr Tim Zhao to markedly enhance the capability for investigating the mechanisms by which intraluminal contents interact with the gut and for screening effective therapeutic regimen for evaluation in clinical trials.

 

PATENTS:

1. Patent Title: METHODS AND COMPOSITION FOR TREATING METABOLIC DISORDERS AND HYPERGLYCAEMIA

Patent Number: AU 2023900718 (Inventors: Tongzhi Wu, Chris Rayner, Richard Young, Chunjie Xiang, Cong Xie, Michael Horowitz, Karen Jones)

2. Patent Title: METHODS AND COMPOSITION FOR PREVENTING AND/OR TREATING DIABETES ASSOCIATED WITH LOW-CALORIE SWEETENERS

Patent Number: AU 2023901506 (Inventors: Tongzhi Wu, Chris Rayner, Richard Young, Tingting Li, Cong Xie, Weikun Huang, Michael Horowitz, Karen Jones)

 

PUBLICATIONS:

Original articles

  1. Wu T, Zhao BR, Bound MJ, Checklin HL, Bellon M, Little TJ, Young RL, Jones KL, Horowitz M, Rayner CK. Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycaemia in healthy humans. Am J Clin Nutr. 2012;95:78-83.
  2. Wu T, Bound MJ, Standfield SD, Jones KL, Horowitz M, Rayner CK. Effects of taurocholic acid on glycaemic, glucagon-like Peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans. J Clin Endocrinol Metab. 2013;98:E718-22. 
  3. Wu T, Bound MJ, Standfield SD, Gedulin B, Jones KL, Horowitz M, Rayner CK. Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes Obes Metab.2013;15:474-7.
  4. Wu T, Bound MJ, Zhao BR, Standfield SD, Bellon M, Jones KL, Horowitz M, Rayner CK. Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycaemia in type 2 diabetes. Diabetes Care. 2013;36:1913-8.
  5. Chang J, Wu T, Greenfield JR, Samocha-Bonet D, Horowitz M, Rayner CK. Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion and antropyloroduodenal motility in health and type 2 diabetes. Diabetes Care. 2013;36:2262-5.
  6. Young RL, Chia B, Isaacs NJ, Ma J, Khoo J, Wu T, Horowitz M, Rayner CK. Disordered control of intestinal sweet taste receptor expression in type 2 diabetes. Diabetes. 2013;62:3532-41.
  7. Wu T, Bound MJ, Standfield SD, Bellon M, Young RL, Jones KL, Horowitz M, Rayner CK. Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycaemia in healthy humans. Diabetes Care. 2013;36:e202-3.
  8. Li F, Chen B, Li L, Zha M, Zhou S, Wu T, Bachem MG, Sun Z. INS-1 cells inhibit the production of extracellular matrix from pancreatic stellate cells. J Mol Histol. 2014;45:321-7.
  9. Wu T, Ma J, Bound MJ, Checklin H, Deacon CF, Jones KL, Horowitz M, Rayner CK. Effects of sitagliptin on glycaemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans, and patients with type 2 diabetes treated with or without metformin. Diabetes. 2014;63:2776-87.
  10. Wu T, Thazhath SS, Bound MJ, Jones KL, Horowitz M, Rayner CK. Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity? Diabetes Res Clin Pract. 2014;106:e3-6.
  11. Thazhath SS, Wu T, Bound MJ, Checklin HL, Jones KL, Willoughby S, Horowitz M, Rayner CK. Changes in meal composition and duration affect postprandial endothelial function in healthy humans. Am J Physiol GastrointestLiver Physiol. 2014;307:G1191-7.
  12. Wu T, Trahair LG, Bound MJ, Deacon CF, Horowitz M, Jones KL, Rayner CK. Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with type 2 diabetes. Diabet Med.2015;32:595-600.
  13. Wu T, Thazhath SS, Marathe CS, Bound MJ, Jones KL, Horowitz M, Rayner CK. Comparative effect of intraduodenal and intrajejunal infusion on the gut-incretin axis response in healthy males. Nutr Diabetes.2015;5:e156.
  14. Yang BQ, Lu Y, He JJ, Wu TZ, Xie ZL, Lei CH, Zhou Y, Han J, Bian MQ, You H, Mei DX, Sun ZL. Performance of Fasting Plasma Glucose and Postprandial Urine Glucose in Screening for Diabetes in Chinese High-risk Population. Chin Med J. 2015;128:3270-3275.
  15. Zhang X, Liu T, Wang Y, Zhong M, Zhang G, Liu S, Wu T, Rayner CK, Hu S. Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats. Obes Surg. 2016;26:1565-75.
  16. Thazhath SS, Wu T, Bound MJ, Checklin HL, Standfield S, Jones KL, Horowitz M, Rayner CK. Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. Am J Clin Nutr. 2016;103:66-70.
  17. Thazhath SS, Marathe CS, Wu T, Chang J, Khoo J, Kuo P, Checklin HL, Bound MJ, Rigda RS, Crouch B, Jones KL, Horowitz M, Rayner CK. The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients With Type 2 Diabetes: A Randomized Controlled Trial. Diabetes. 2016;65:269-75.
  18. Wu T, Little TJ, Bound MJ, Borg M, Zhang X, Deacon CF, Horowitz M, Jones KL, Rayner CK. A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes. Diabetes Care. 2016;39:511-7.
  19. Thazhath SS, Wu T, Bound MJ, Checklin HL, Standfield S, Jones KL, Horowitz M, Rayner CK. Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: A randomised controlled trial. Nutrition. 2016;32:553-9.
  20. Chen C, Hu B, Wu T, Zhang Y, Xu Y, Feng Y, Jiang H. Bile acid profiles in diabetic (db/db) mice and their wild type littermates. J Pharm Biomed Anal. 2016;131:473-481.
  21. Wu T, Zhang X, Trahair LG, Bound BM, Little TJ, Deacon CF, Horowitz M, Jones KL, Rayner CK. Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes. J Clin Endocrinol Metab. 2016;101:4769-4778.
  22. Rigda RS, Trahair LG, Little TJ, Wu T, Standfield SD, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects. Peptides.2016;86:126-132.
  23. Thazhath SS, Marathe CS, Wu T, Chang J, Khoo J, Kuo P, Checklin HL, Bound MJ, Rigda RS, Crouch B, Jones KL, Horowitz M, Rayner CK. Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes. Diabetes Vasc Dis Res. 2017;14:59-63.
  24. Wu T, Xie C, Wu H, Horowitz M, Jones KL, Rayner CK. Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes Obes Metab. 2017;19:290-93.
  25. Wu T, Trahair LG, Little TJ, Bound MJ, Zhang X, Wu H, Sun Z, Horowitz M, Rayner CK, Jones KL. Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes. Diabetes Care. 2017;40:702-5.
  26. Wu T, Rayner CK, Watson LE, Jones KL, Horowitz M, Litter TJ. Comparative Effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males. Peptides. 2017;95:124-127.
  27. Trahair LG, Wu T, Feinle-Bisset C, Marathe CS, Rayner CK, Horowitz M, Jones KL. Comparative effects of small intestinal glucose on blood pressure, heart rate and noradrenaline responses in obese, and healthy, subjects. Physiol Rep. 2018;6(4). doi: 10.14814/phy2.13610.
  28. Rigda RS, Trahair LG, Wu T, Little TJ, Lange K, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Effects of length and region of small intestine exposed to glucose on blood pressure, superior mesenteric artery blood flow and plasma noradrenaline in healthy older subjects. J Aging Res Clin Practice. 2018;7:149-155.
  29. Young RL, Lumsden AL, Martin AM, Schober G, Pezos N, Thazhath SS, Isaacs NJ, Cvijanovic N, Sun EWL, Wu T, Rayner CK, Nguyen NQ, Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Wattchow DA, Liou AP, Jackson VM, Keating DJ. Augmented capacity for peripheral serotonin release in human obesity. Int J Obes. 2018;42(11):1880-9. 
  30. Pham HT, Stevens JE, Rigda RS, Phillips LK, Wu T, Hausken T, Soenen S, Visvanathan R, Rayner CK, Horowitz M, Jones KL. Effects of intraduodenal administration of the artificial sweetener, sucralose, on blood pressure and superior mesenteric artery blood flow in healthy older subjects. Am J Clin Nutr. 2018;108(1):156-162.
  31. Veedfald S, Wu T, Bound M, Grivell J, Hartmann B, Rehfeld JF, Deacon CF, Horowitz M, Holst JJ, Rayner CK. Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men. J Clin Endocrinol Metab. 2018;103(12):4409-18. 
  32. Borg MJ, Bound M, Grivell J, Sun Z, Jones KL, Horowitz M, Rayner CK, Wu T. Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon-like peptide-1, and gastric emptying after oral glucose, in type 2 diabetes. Diabetes Obes Metab. 2019;21(3):640-647.
  33. Borg MJ, Jones KL, Sun Z, Horowitz M, Rayner CK, Wu T. Metformin attenuates the postprandial fall in blood pressure in type 2 diabetes. Diabetes Obes Metab. 2019;21(5):1251-1254.
  34. Jones KL, Rigda RS, Buttfield MDM, Hatzinikolas S, Pham HT, Marathe CS, Wu T, Lange K, Trahair LG, Rayner CK, Horowitz M. Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycemia in health and type 2 diabetes. Diabetes Obes Metab. 2019;21(5):1158-1167.
  35. Zhang X, Young RL, Bound M, Hu S, Jones KL, Horowitz M, Rayner CK, Wu T.  Comparative effects of proximal and distal small intestinal glucose exposure on glycemia, incretin hormone secretion and the incretin effect in health and type 2 diabetes. Diabetes Care. 2019;42(4):520-528.
  36. Shi R, Wang Y, An X, Ma J, Wu T, Yu X, Liu S, Huang L, Wang L, Liu J, Ge J, Qiu S, Yin H, Wang X, Wang Y, Yang B, Yu J, Sun Z. Efficacy of Co-administration of Liuwei Dihuang Pills and Ginkgo Biloba Tablets on Albuminuria in Type 2 Diabetes: A 24-Month, Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Front Endocrinol. 2019 Feb 22;10:100.
  37. Watson LE, Phillips LK, Wu T, Bound MJ, Checklin HL, Grivell J, Jones KL, Clifton PM, Horowitz M, Rayner CK. A whey/guar "preload" improves postprandial glycaemia and HbA1c in type 2 diabetes - a 12-week, single-blind, randomized, placebo-controlled trial. Diabetes Obes Metab. 2019 Apr;21(4):930-938
  38. Watson LE, Phillips LK, Wu T, Bound MJ, Checklin HL, Grivell J, Jones KL, Horowitz M, Rayner CK. Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clin Nutr. 2019 Dec;38(6):2827-2832.
  39. Watson LE, Xie C, Wang X, Li Z, Phillips LK, Sun Z, Jones KL, Horowitz M, Rayner CK, Wu T. Gastric emptying in patients with well-controlled type 2 diabetes compared to non-diabetic young and older controls. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3311-3319.
  40. Bitarafan V, Fitzgerald PCE, Little TJ, Meyerhof W, Wu T, Horowitz M, Feinle-Bisset C. Intraduodenal infusion of the bitter tastant, quinine, does not modulate antropyloroduodenal motility, plasma cholecystokinin or energy intake in healthy men. J Neurogastroenterol Motil. 2019 Jul 1;25(3):413-422.
  41. Watson LE, Phillips LK, Wu T, Bound MJ, Jones KL, Horowitz M, Rayner CK. Longitudinal evaluation of gastric emptying in type 2 diabetes. Diabetes Res Clin Pract. 2019 Aug;154:27-34.
  42. Pham H, Holen IS, Phillips LK, Hatzinikolas S, Huynh LQ, Wu T, Hausken T, Rayner CK, Horowitz M, Jones KL.The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects. Nutrients. 2019 Nov 5;11(11). pii: E2666.
  43. Pham H, Marathe CS, Phillips LK, Trahair LG, Hatzinikolas S, Huynh L, Wu T, Nauck M, Rayner CK, Horowtiz M, Jones KL. Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP in healthy older subjects. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6201-6206.
  44. Stevens JE, Buttfield M, Wu T, Hatzinikolas S, Pham H, Lange K, Rayner CK, Horowitz M, Jones CK. Effects of sitagliptin on gastric emptying of, and the glycaemic and blood pressure responses to, a carbohydrate meal in type 2 diabetes. Diabetes Obes Metab. 2020 Jan;22(1):51-58.
  45. Wang X, Xie C, Marathe CS, Malbert CH, Horowitz M, Jones KL, Rayner CK, Sun Z, Wu T. Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes. Diabetes Res Clin Pract. 2020 Jan;159:107951
  46. Bitarafan V, Fitzgerald PCE, Little TJ, Meyerhof W, Jones KL, Wu T, Horowitz M, Feinle-Bisset C. Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men. Am J Physiol Regul Integr Comp Physiol. 2020 Feb 1;318(2):R263-R273.
  47. Huang W, Wu T*, Shallan A, Kostecki R, Rayner CK, Priest C, Ebendorff-Heidepriem H, Zhao J* (*joint senior authorship). A Multiplexed Microfluidic Platform toward Interrogating Endocrine Function: Simultaneous Sensing of Extracellular Ca2+ and Hormone. ACS Sens. 2020 Feb 28;5(2):490-499
  48. Xie C, Wang X, Jones KL, Horowitz M, Sun Z, Little TJ, Rayner CK, Wu T. Role of endogenous glucagon-like peptide-1 enhanced by vildagliptin in the glycaemic and energy expenditure responses to intraduodenal fat infusion in type 2 diabetes. Diabetes Obes Metab. 2020 Mar;22(3):383-392.
  49. Jones KL, Huynh LQ, Hatzinikolas S, Rigda RS, Phillips LK, Pham HT, Marathe CS, Wu T, Malbert CH, Stevens JE, Lange K, Rayner CK, Horowitz M. Exenatide once weekly slows gastric emptying of solids and liquids in healthy, overweight people at steady-state concentrations. Diabetes Obes Metab. 2020 May;22(5):788-797
  50. Marathe CS, Pham H, Marathe JA, Trahair LG, Huynh L, Wu T, Phillips LK, Rayner CK, Nauck MA, Horowitz M, Jones KL. The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance. Acta Diabetol. 2020 May;57(5):583-587
  51. Qiu S, Cai X, Wu T, Sun Z, Guo H, Kirsten J, Wendt J, Steinacker JM, and Schumann U. Objectively-measured light-intensity physical activity and risk of cancer mortality: a meta-analysis of prospective cohort studies. Cancer Epidemiol Biomarkers Prev. 2020 May;29(5):1067-1073
  52. Rayner CK, Watson LE, Phillips LK, Lange K, Bound MJ, Grivell J, Wu T, Jones KL, Horowitz M, Ferrannini E, Trico D, Frascerra Mari A, Natali A. Effects of sustained treatment with lixisenatide on gastric emptying and postprandial glucose metabolism in type 2 diabetes: a randomized controlled trial. Diabetes Care. 2020 Aug;43(8):1813-1821
  53. Zhang X, Jones KL, Horowitz M, Rayner CK, Wu T. Effects of proximal and distal enteral glucose infusion on cardiovascular response in health and type 2 diabetes. J Clin Endo Metab. 2020 Aug 1;105(8):dgaa341
  54. Qiu S, Cai X, Jia L, Sun Z, Wu T, Wendt J, Steinacker JM, Schumann U. Does objectively-measured light-intensitity physical activity reduce the risk of cardiovascular mortality? A Meta-analysis. Eur Heart J Qual Care Clin Outcomes 2020 Jun 8:qcaa051
  55. Jalleh R, Pham H, Marathe CS, Wu T, Buttfield M, Hatzinikaloas S, Malbert CH, Rigda R, Lange K, Trahair L, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Acute effects of lixisenatide on energy intake in healthy subjects and patients with type 2 diabetes – relationship to gastric emptying and intragastric distribution. Nutrients.2020 Jul 1;12(7):1962
  56. Xie C, Wang X, Jones KL, Horowitz M, Sun Z, Little TJ, Rayner CK, Wu T. Comparative effects of intraduodenal glucose and fat on blood pressure and heart rate in type 2 diabetes. Front Nutr 2020 Nov 9;7:582314.
  57. Rayner CK, Wu T, Aroda VR, Whittington C, Kanters S, Guyot P, Shaunic A, Horowitz M. Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus GLP-1 RAs in people with type 2 diabetes mellitus: a network meta-analysis. Diabetes Obes Metab. 2021 Jan;23(1):136-146.
  58. Xie C, Huang W, Wang X, Trahair LG, Pham HT, Marathe CS, Young RL, Jones KL, Horowitz M, Rayner CK, Wu T. Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink. Diabetes Res Clin Pract. 2021 Jan;171:108610.
  59. Qiu S, Cai X, Sun Z, Wu T, Schumann U. Is estimated cardiorespiratory fitness an effective predictor for cardiovascular and all-cause mortality? A meta-analysis. Atherosclerosis. 2021;330:22-28.
  60. Qiu S, Cai X, Xie B, Yuan Y, Sun Z, Wu T. Normalized creatinine-to-cystatin C ratio and risk of diabetes in middle-aged and older adults: the China Health and Retirement Longitudinal Study. Diabetes Metab J. 2022 Mar 7. doi: 10.4093/dmj.2021.0074.
  61. Qiu S, Cai X, Yuan Y, Xie B, Sun Z, Wu T. Changes in creatine-to-cystatin C ratio over 4-year, risk of diabetes, and cardiometabolic control: the China Health and Retirement Longitudinal Study. J Diabetes. 2021 Dec;13(12):1025-1033
  62. Xie C, Huang W, Watson LE, Soenen S, Young RL, Jones KL, Horowitz M, Rayner CK, Wu T. Plasma GLP-1 response to oral and intraduodenal nutrients in health and type 2 diabetes – impact on gastric emptying. J Clin Endo Metab. 2022 Mar 24;107(4):e1643-e1652.
  63. Qiu S, Cai X, Yuan Y, Xie B, Sun Z, Wang D, Wu T. Muscle strength and prediabetes progression and regression in middle-aged and older adults: a prospective cohort study. J Cachexia Scarcopenia Muscle. 2022 Apr;13(2):909-918. 
  64. Qiu S, Cai X, Zheng P, Yuan Y, Xu Y, Jia L, Sun Z, Wu T. Changes in objectively-measured physical capability over 4-year, risk of diabetes, and glycaemic control in older adults: the China Health and Retirement Longitudinal Study. Diabetes Res Clin Pract. 2021 Dec 28;184:109186.
  65. Wang X, Chen C, Xie C, Huang W, Young RL, Jones KL, Horowitz M, Rayner CK, Sun Z, Wu T. Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2h plasma glucose in individuals without diabetes. Diabetes Obes Metab. 2022 Jun;24(6):1132-1142.
  66. Jones KL, Trahair LG, Nauck MA, Wu T, Stevens JE, Buttfield MD, Hatzinikolas S, Pham H, Meier JJ, Rayner CK, Horowitz M. Measurement of gastric emptying using a 13C-octanoic acid breath test with Wagner-Nelson analysis and scintigraphy in type 2 diabetes. Exp Clin Endocrinol Diabetes. 2022;130(11):1132-1142. 
  67. Marathe CS, Pham H, Wu T, Trahair LG, Rigda RS, Buttfield MDM, Hatzinikolas S, Lange K, Rayner CK, Mari A, Horowitz M, Jones KL. Acute administration of the GLP-1 agonist, lixisenatide, diminishes postprandial insulin secretion in healthy subjects but not in type 2 diabetes, associated with slowing of gastric emptying. Diabetes Ther. 2022;13(6):1245-1249.
  68. Zhang X, Cheng Z, Dong s, Rayner CK, Wu T, Zhong M,  Zhang G, Wang K, Hu S. Effects of ileal glucose infusion on enteropancreatic hormone secretion in humans: relationship to glucose absorption. Metabolism. 2022 Jun;131:155198. 
  69. Sang M, Liu Y, Wu T, Zhou X, Wang D, Sun Z, Qiu S. Association of a novel electrolyte index, SUSPPUP, base on the measurement of fasting serum and spot urinary sodium and potassium, with prediabetes and diabetes in Chinese population. Clin Chim Acta. 2022 May 4:S0009-8981(22)01134-2. 
  70. Yao J, Li W, Liu Y, Wu T, Wang D, Arezina R, Sun Z, Qiu S. Investigation of the association between lens autofluorescence ratio and diabetes: a cross-sectional study. Photodiagnosis Photodyn Ther. 2022 Apr 28:102888. 
  71. Xie B, Cai X, Zhu Y, Sun Z, Qiu S, Wu T. Accelerometer-measured light-intensity physical activity and risk of cardiovascular disease or death in older adults: A meta-analysis. Kardiol Pol. 2022;80(7-8):774-781.
  72. Sang M, Xie C, Qiu S, Wang X, Horowitz M, Jones KL, Rayner CK, Wu T. Cholecystectomy is associated with dysglycaemia: cross-sectional and prospective analyses. Diabetes Obes Metab. 2022 Aug;24(8):1656-1660.
  73. Qiu S, Cai X, Yuan Y, Xie B, Sun Z, Wu T. Is imaging -based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies. Diabetes Res Clin Pract. 2022 [in press]
  74. Jalleh RJ, Wu T, Jones KL, Rayner CK, Horowitz M, Marathe CS. Relationships of glucose, GLP-1 and insulin secretion with gastric emptying after a 75g glucose load in type 2 diabetes. J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3850-e3856.
  75. Sang M*, Wu T* (co-first author), Zhou X, Horowitz M, Jones KL, Qiu S, Guo H, Wang B, Rayner CK#, Sun Z#.  Prevalence of gastrointestinal symptoms in Chinese community-dwelling adults with and without diabetes. Nutrients. 2022 Aug 26;14(17):3506.
  76. Qiu S, Wang Q, Cai X, Sun Z, Wu T. Circulating irisin in nonalcoholic fatty liver disease: an updated meta-analysis. Endokrynologia Polska. 2023;74(1):47-54.
  77. Huang W, Xie C, Albrechtsen NJW, Jones KL, Horowitz M, Rayner CK, Wu T. The ‘early’ postprandial glucagon response is related to the rate of gastric emptying in type 2 diabetes. Peptides. 2023 Mar;161:170941.
  78. Qiu S, Wang Q, Chen W, Xie B, Wang D, Cai X, Sun Z, Wu T. Cumulative muscle strength and risk of cardiovascular disease and all-cause mortality: a prospective cohort study. Arch Med Res. 2023 Apr;54(3):261-269.
  79. Li Y, Zhang D, Mo Y, Zeng T, Wu T, Liu L, Zhang H, Chen C. Simultaneous determination of sex hormones and bile acids in rate plasma using a liquid chromatography-tandem mass spectrometry method. J Pharm Biomed Anal. 2023;223:115139.
  80. Qiu S, Zhu Y, Xie B, Chen W, Wang D, Cai X, Sun Z, Wu T. Prediabetes progression and regression on objectively measured physical function: a prospective cohort study. Diabetes Metab J. 2023 [in press]
  81. Jalleh RJ, Trahair LG, Wu T, Standfield S, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy subjects. Diabetes Obes Metab. 2023 Jul:25(7):1849-1854.
  82. Xie C, Jalleh RJ, Watson LE, Huang W, Sun Y, Jones KL, Horowitz M, Rayner CK, Wu T. Determinants of blood glucose concentrations following a high carbohydrate meal in type 2 diabetes: A multiple linear regression analysis. Diabetes Res Clin Pract. 2023 Apr;198:110606.
  83. Xie C, Huang W, Sun Y, Xiang C, Trahair L, Jones KL, Horowitz M, Rayner CK, Wu T. Disparities in the glycaemic and incretin responses to intraduodenal glucose infusion between healthy young men and women. J Clin Endocrinol Metab. 2023 Aug 18;108(9):e712-e719.
  84. Zhou X, Lu H, Sang M, Qiu S, Yuan Y, Wu T, Chen J, Sun Z. Impaired antibody response to inactivated COVID-19 vaccines in hospitalized patients with type 2 diabetes. Hum Vaccin Immunother. 2023;19(1):2184754.
  85. Qiu S, Cai X, Liang Y, Chen W, Wang D, Sun Z, Xie B, Wu T. Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis. Diabetes Res Clin Pract. 2023 Mar;197:110526.
  86. Huang W, Xie C, Wewer Albrechtesen JJ, Sang M, Sun Z, Jones KL, Horowitz M, Rayner CK, Wu T. Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes. Peptides. 2023 Nov;169:171092.
  87. Qiu S, Cai X, Zhou X, Xu J, Sun Z, Guo H, Wu T. Muscle quality in relation to prediabetes phenotypes: a population-based study with mediation analysis. J Clin Endocrinol Metab. [in press]

 

Reviews

  1. Wu T, Rayner CK, Jones K, Horowitz M. Dietary effects on incretin hormone secretion. Vitam Horm 2010;84:81-110.
  2. Wu T, Rayner CK, Young RL, Horowitz M. Gut motility and enteroendocrine secretion. Curr Opin Pharmacol. 2013;13:928-34. 
  3. Thazhath SS, Wu T, Young RL, Horowitz M, Rayner CK. Glucose absorption in small intestinal diseases. Expert Rev Gastroenterol Hepatol. 2014;8:301-12.
  4. Mignone LE, Wu T, Horowitz M, Rayner CK. Whey protein: The "whey" forward for treatment of type 2 diabetes? World J Diabetes. 2015;6:1274-84.
  5. Wu T, Rayner CK, Horowitz M. Inter-regulation of gastric emptying and incretin hormone secretion – implications for postprandial glycaemic control. Biomark Med. 2016;10(11):1167-79.
  6. Wu T, Horowitz M, Rayner CK. New insights into the anti-diabetic actions of metformin: from the liver to the gut. Expert Rev Gastroenterol Hepatol. 2017;11:157-66.
  7. Xie C, Wang X, Young RL, Horowitz M, Rayner CK, Wu T. Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control. Front Endocrinol. 2018 Sep 27;9:576. 
  8. Kreuch D, Keating DJ, Wu T, Horowitz M, Rayner CK, Young RL. Gut mechanisms linking intestinal sweet sensing to glycemic control. Front Endocrinol. 2018 Dec 4;9:741.
  9. Sansome DJ, Xie C, Veedfald S, Horowitz M, Rayer CK, Wu T. Role of bile acids in glucose lowering by metformin in type 2 diabetes. Diabetes Obes Metab. 2020 Feb;22(2):141-148.
  10. Huang W, Xie C, Young RL, Zhao J, Ebendorff-Heidepriem H, Jones KL, Rayner CK, Wu T. Development of innovative tools for investigation of nutrient-gut interaction. World J Gastroenterol. 2020 Jul 7;26(5):3562-3576
  11. Xie C, Jones KL, Rayner CK, Wu T. Enteroendocrine Hormone Secretion and Metabolic Control: Importance of the Region of the Gut Stimulation. Pharmaceutics. 2020 Aug 21;12(9):E790
  12. Marathe CS, Jones KL, Wu T, Rayner CK, Horowitz M. Gastrointestinal autonomic neuropathy in diabetes. Auton Neurosci. 2020 Aug 15;229:102718
  13. Wu T, Rayner CK, Jones KL, Xie C, Marathe CS, Horowitz M. Role of intestinal glucose absorption in glucose tolerance. Curr Opin Pharmacol. 2020;55:116-124.
  14. Borg MJ, Rayner CK, Jones KL, Horowitz M, Xie C, Wu T. Gastrointestinal mechanisms underlying the cardiovascular effect of metformin. Pharmaceuticals. 2020;13(11):410.
  15. Borg MJ, Xie C, Rayner CK, Horowitz M, Jones KL, Wu T. Potential for gut peptide-based therapy in postprandial hypotension. Nutrients. 2021;13(8):2826.
  16. Xie C, Huang W, Young RL, Jones KL, Horowitz M, Rayner CK, Wu T. Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease. Nutrients. 2021;13(4):1104.
  17. Dong S, Qian L, Cheng Z, Chen C, Wang K, Hu S, Zhang X, Wu T. Lactate and myocardiac energy metabolism. Front Physiol. 2021 [In press]
  18. Huang W, Wu T*, Xie C, Rayner CK, Priest C, Ebendorff-Heidepriem, Zhao J* (*joint sensor author). Sensing intra- and extracellular Ca2+ in the islet of Langerhans. Advanced Functional Materials. 2021 [In press]
  19. Normal and disordered gastric emptying in diabetes: recent insights into (patho)physiology, management and impact on glycaemic control. Jalleh RJ, Jones KL, Rayner CK, Marathe CS, Wu T, Horowitz M. Diabetologia.2022 Dec;65:1981-1993.

Editorials

  1. Horowitz M, Wu T, Deane AM, Jones KL, Rayner CK. Dipeptidyl Peptidase 4 and the known unknown. Diabetes 2016;65:2124-26.
  2. Rayner CK, Jones KL, Wu T, Horowitz M. Gut feelings about diabetes and GLP-1 receptor agonists – lessons to be learnt from studies in functional gastrointestinal disorders. Diabetes Obes Metab. 2017;19:309-12.
  3. Wu T, Rayner CK, Marathe CS, Jones KL, Horowitz M. Glucagon receptor signalling – backwards and forwards. Expert Opin Investig Drugs. 2018  Feb;27(2):135-138.
  4. Marathe CS, Rayner CK, Wu T, Jones KL, Horowitz M. Gastric emptying and the personalized management of type 1 diabetes. J Clin Endocriol Metab. 2018 Sep 1;103(9):3503-3506.
  5. Horowitz M, Wu T, Rayner CK, Marathe CS, Jones KL. Spontaneous or deliberate: effects of acute variations in glycemia on gastric emptying in type 1 diabetes. Diabetes Care 2021 Feb;44(2):316-318.
  6. Qiu S, Ma J, Wu T. Editorial: Management of diabetes and its complications: a focus on endothelial dysfunction. Front Endocrinol. 2022 Mar 18;13:857983.
  7. Wu T, Rayner CK, Jones KL, Horowitz M. Seize the whey! Whey preloads for control of postprandial glycemia in metabolic disease. Am J Clin Nutr. 2023;118(2):345-346.

Letters

  1. Wu T, Marathe CS, Horowitz M, Jones KL, Rayner CK. Comment on Russell-Jones et al. Diabetes Care 2017;40:943–950. Comment on Bowering et al. Diabetes Care 2017;40:951–957. Diabetes Care. 2018;41:e27-28.
  2. Sansome DJ, Xie C, Veedfald S, Horowitz M, Rayer CK, Wu T. Statins and glycaemic control in type 2 diabetes: are bile acids relevant? Br J Clin Pharmacol. 2020 Dec;86(12):2538-2539.
  3. Horowitz M, Rayner CK, Marathe CS, Wu T, Jones KL. Glucagon-like peptide-1 receptor agonists and the appropriate measurement of gastric emptying. Diabetes Obes Metab. 2020 Dec;22(12):2504-2506.
  4. Marathe CS, Jones KL, Rayner CK, Wu T, Horowitz M. Comment on Rosenstock et al.  Impact of a Weekly Glucagon-Like Peptide-1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial. Diabetes Care. 2021 [in press]
  5. Horowitz M, Rayner CK, Marathe CS, Wu T, Umapathysivam M, Jones KL. Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. Diabetes Obes Metab. 2021 Oct;23(10):2411-2413. 
  6. Sang M, Sun Z, Wu T. Inflammatory bowel disease and diabetes: is there a link? World J Diabetes. 2022 Feb 15;13(2):126-128. 
  7. Wu T, Rayner CK, Jones KL, Horowitz M, Feinle-Bisset C, Standfield SD, Xie C, Deacon CF, Holst JJ, Wewer Albrechtsen NJ. Measurement of plasma glucagon in humans – a shift in the performance of a current commercially available radioimmunoassy kit. Diabetes Obes Metab. 2022  Jun;24(6):1182-1184.
  8. Qiu S, Cai X, Sun Z, Wu T. Comment on ‘Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study’ by Kaga et al. J Cachexia Sarcopenia Muscle. 2023;14(5):2452-2453.

Book chapters

  1. Wu T, Rayner CK, Horowitz M. Incretins. Handb Exp Pharmacol. 2016;233:137-71.
  2. Watson LE, Wu T, Horowitz M, Rayner CK. Whey protein and diabetes. Milk in Human Health and Disease Across Lifespan. 2017 [edited by Watson RR et al.]
  3. Marathe CS, Rayner CK, Wu T, Jones KL, Horowitz M. Diabetes and the gastrointestinal tract. In book: 2020. In: Kuipers, EJ (ed.) Encyclopedia of Gastroenterology, 2nd edition, pp. 9-12. Oxford: Academic Press.
  4. Marathe CS, Rayner CK, Wu T, Jones KL, Horowitz M. Gastrointestinal disorders in diabetes. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. 2020 Jan 11.
  5. Jones KL, Marathe CS, Wu T, Rayner CK, Horowitz M. Gastrointestinal neurophathy. Diabetic Neuropathy: Clinical Management (3rd ed). 2021 [in press]

 

  • Appointments
    Date Position Institution name
    2021 - ongoing Associate Professor (Level D) The University of Adelaide
    2020 - ongoing THRF Mid-Career Fellow (Level C) The University of Adelaide
    2018 - 2020 RAH Florey Fellow (GFS-5) Royal Adelaide Hospital
    2015 - 2017 RAH Mary Overton Early Career Fellow (Level A) The University of Adelaide
    2014 - 2014 Clinical Research Fellow (Level A) The University of Adelaide
    2007 - 2009 Physician Trainee Zhongda Hospital Southeast University
    2006 - 2007 Intern (First Class) Zhongda Hospital Southeast University

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2021 Research Award Emerging Leader Award Faculty of Health and Medical Sciences, The University of Adelaide Australia -
    2020 Fellowship THRF Mid-Career Fellowship The Hospital Research Foundation Australia -
    2019 Award Clinical Science Poster Award Australian Diabetes Society Australia -
    2019 Award Travel Award European Association for the Study of Diabetes Germany -
    2018 Award Northern Communities Health Foundation Derek Frewin Early Career Research Award Northern Communities Health Foundation Australia -
    2018 Fellowship Royal Adelaide Hospital Florey Fellowship Royal Adelaide Hospital Research Committee Australia -
    2016 Award Executive Dean's Award for Research Excellence (Early Career Researcher) The University of Adelaide - -
    2016 Award Travel Award European Association for the Study of Diabetes - €1500
    2016 Award Travel Award University of Adelaide, School of Medicine Australia 2835
    2015 Fellowship Early Career Fellowship Royal Adelaide Hospital Australia -
    2015 Recognition Best Poster Australian Diabetes Society Australia -
    2015 Award Travel Grant University of Adelaide, Discipline of Medicine Australia -
    2014 Research Award University Doctoral Research Medal University of Adelaide Australia -
    2013 Recognition Dean's commendation for thesis excellence University of Adelaide Australia -
    2013 Award Travel Award, Diabetes Congress International Diabetes Federation (IDF) Australia -
    2013 Fellowship Travelling Fellowship University of Adelaide, Discipline of Medicine Australia 2600
    2012 Award Travel Award European Association for the Study of Diabetes - €2000
    2011 Award Travel Award European Association for the Study of Diabetes - €2000
    2011 Fellowship Postgraduate Travelling Fellowship University of Adelaide Australia 1700
    2010 Recognition Best Poster Presentation University of Adelaide, Research Expo Australia -
    2009 Recognition Outstanding Postgraduate in Clinical Medicine Southeast University Australia -
    2009 Scholarship Postgraduate Scholarship China Scholarship Council China -
    2009 Scholarship Postgraduate Supplementary Scholarship Centre of Research Excellence in Translating Nutritional Science to Good Health Australia -
    2007 Scholarship First-class postgraduate scholarship Southeast University China -
    2007 Recognition Outstanding Graduate in Clinical Medicine Southeast University China -
    2006 Recognition 'Excellent Student Researcher' in the Student Research Training Program (SRTP) Southeast University China -
    2004 Scholarship 'Zi-guang' Scholarship Southeast University Australia -

  • Education
    Date Institution name Country Title
    2009 - 2013 University of Adelaide Australia Doctor of Philosophy
    2007 - 2009 Southeast University China Master of Clinical Medicine
    2002 - 2007 Southeast University China Bachelor of Clinical Medicine

  • Research Interests
    Clinical Trials Endocrinology & Metabolism Medical Biochemistry: Proteins and Peptides Medical Physiology Nutrition and Metabolic Health Translational Health Outcomes

2023                           Diabetes Australia Project Grant (ID: Y23G-WUTO) ($70,000)

Project title: Harnessing bile acid sensing mechanisms to improve the management of type 2 diabetes.

Chief Investigators: Tongzhi Wu, Chris Rayner, Richard Young, Michael Horowitz, Karen Jones, Cong Xie, Heike Ependorff-Heidepriem, Weikun Huang.

 

2023                           Diabetes Australia Project Grant (ID: Y23G-RAYN) ($70,000)

Project title: Impact of renal 'sweet taste' sensing on the risk of dysglycaemia.

Chief Investigators: Chris Rayner, Tongzhi Wu, Richard Young, Merlin Thomas, Cong Xie, Weikun Huang.

 

2022 – 23                    Diabetes SA Project Grant. ($100,000)

Blocking intestinal sweet taste for better control of glycaemia in type 2 diabetes. Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu, Kerry Ivey, Geraint Rogers.

 

2022 – 23                    Diabetes Australia Project Grant (ID: Y22G-YOUR). ($70,000)

Host or the hosted? Mechanisms underlying intestinal control of glycaemia in type 2 diabetes. Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu, Geraint Rogers, Kerry Ivey.

 

2022 – 23                    Diabetes Australia Project Grant (ID: Y22G-JONK). ($70,000)

Effect of subcutaneous (sc) semaglutide on gastric emptying measured using the ‘gold standard’ technique, scintigraphy, in type 2 diabetes (T2D). Karen Jones, Michael Horowitz, Christ Rayner, Chinmay Marathe, Tongzhi Wu, Lee-ann Chapple.

 

2022                            Gum Bequest – Royal Adelaide Hospital ($40,000)

Project title: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, a carbohydrate meal in type 2 diabetes. Karen Jones, Michael Horowitz, Chris Rayner, Tongzhi Wu, Chinmay Marathe.

 

2021                            University of Adelaide, Faculty of Health and Medical Sciences - 2021 Research Infrastructure Funding Award ($130,328)

 

Project title: LOGIQ E10 Ultrasound system – portable 3D ultrasound device and software. Karen Jones, Tongzhi Wu, Chris Rayner, Chinmay Marathe, Lee-ann Chapple, M Horowitz.

 

2021                            University of Adelaide, Faculty of Health and Medical Sciences - 2021 Small Equipment funding Award – Microfluidic perfusion pump ($2,470).

Tongzhi Wu, Richard Young, Lisa Nicholas, Weikun Huang.

 

2021                            University of Adelaide, Faculty of Health and Medical Sciences - 2021 Small Equipment funding Award – Refrigerated benchtop microcentrifuge ($5,999).

Lisa Nicholas, Sarah Roberston, Tongzhi Wu.

 

2021 – 22                    Diabetes Australia Project Grant (ID: Y21G-YOUR). ($60,000)

Project title: Blocking intestinal sweet taste for glycaemic benefits in type 2 diabetes. Richard Young, Geraint Rogers, Chris Rayner, Michael Horowitz, Tongzhi Wu.

 

2021 – 22                    Diabetes Australia Project Grant (ID: Y21G-WUTO). ($60,000)

Project Title: More or less? Bile acids and glycaemic control in type 2 diabetes. Tongzhi Wu, Chris Rayner, Karen Jones, Richard Young, Michael Horowitz.

 

2020 – 23                    The Hospital Research Foundation Mid-Career Fellowship ($600,000)

                                    Project title: Developing novel ‘gut-based’ therapies for type 2 diabetes

                                    Tongzhi Wu

 

2020 – 22                    Royal Adelaide Hospital Research Committee Clinical Project Grant ($48,286)

                                    Project title: GLP-1 for lowering plasma glucose in type 2 diabetes: A systemic comparison of intravenous and subcutaneous routes

                                    Chris Rayner, Daniel Quast, Tongzhi Wu

 

2020 – 22                    Royal Adelaide Hospital Research Committee Clinical Project Grant ($50,000)

                                    Project title: Effects of endogenous bile acids on postprandial glucose metabolism in both health and type 2 diabetes, and the impact of the small intestinal region exposed

                                    Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz

 

2020 – 22                    Diabetes Australia Project Grant (Y20G-YOUR) ($59,762)

                                    Project title: Does the gut microbiome link intake of low-calorie sweeteners to impaired blood glucose control?

                                    Richard Young, Geraint Rogers, Chris Rayner, Michael Horowitz, Tongzhi Wu

 

2020 – 22                    Diabetes Australia Project Grant (Y20G-WUTO) ($59,970)

                                    Project title: Effects of endogenous bile acids on postprandial glucose metabolism in type 2 diabetes, and the impact of the small intestinal region exposed

                                    Tongzhi Wu, Chris Rayner, Liza Phillips, Karen Jones, Michael Horowitz

 

2019 – 20                    Diabetes Australia Project Grant (Y19G-WUTO) ($59,991)

                                    Project title: Role of bile acids in glucose-lowering by metformin

                                    Tongzhi Wu, Chris Rayner, Karen Jones, Michael Horowitz

 

2019 – 20                    RAH Research Foundation Clinical Project Grant ($49,998)

Project title: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes.

Tongzhi Wu, Liza Phillips, Chris Rayner, Karen Jones, Michael Horowitz

 

2019                            Diabetes Australia Project Grant (Y19G-JONK) ($59,872)

Project title: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, an oral glucose load in type 2 diabetes.

Karen Jones, Liza Phillips, Tongzhi Wu, Chinmay Marathe, Michael Howoritz, Chris Rayner.

 

2018 – 22                    NHMRC Project Grant (APP1147333) ($725,276)

Project title: Bitter taste as a mediator of food intake and postprandial glycaemia in type 2 diabetes.

Tongzhi Wu, Chris Rayner, Karen Jones, Richard Young, Christine Feinle-Bisset

 

2018 – 22                    NSFC Project Grant (81870561) ($120,000)

                                    Project title: Effects of intestinal bitter taste sensing on gastrointestinal hormone secretion and glycaemic control

                                    Tongzhi Wu, Chris Rayner, Richard Young, Qin Lu, Dong Wang, Xuyi Wang, Juan Chen, Min Cai, Min Ge

 

2018 – 20                    RAH Research Foundation Florey Fellowship ($348,000)

Tongzhi Wu

 

2018 – 20                    Diabetes Australia Millennium Grant ($150,000)

Project title: Do artificial sweeteners affect glycaemic control in T2DM adversely?

Richard Young, Chris Rayner, Michael Horowitz, Tongzhi Wu

 

2018 – 19                    RAH Research Foundation Clinical Project Grant ($49,472)

Project title: Role of endogenous glucose-dependent insulinotropic polypeptide in the gastric emptying, glycaemia, splanchnic blood flow and blood pressure responses to oral glucose in healthy older subjects.

Karen Jones, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz

 

2018 – 19                    RAH Research Foundation Clinical Project Grant ($49,710)

Project title: Molecular events linking artificial sweetener intake to augmented glucose absorption and dysglycaemia in health and type 2 diabetes.

Richard Young, Nam Nguyen, Chris Rayner, Tongzhi Wu, Dylan Bartholomeusz, Michael Horowitz

 

2017 – 19                    Investigator-initiated study funded by Novartis (CLAF237AAU09T) ($211,106)

                                    Defining the role of endogenous glucagon-like peptide-1 (GLP-1) in the glycaemic, triglyceride and energy expenditure responses to fat in patients with type 2 diabetes using Galvus (vildagliptin) and the GLP-1 receptor antagonist exendin(9-39). Tongzhi Wu

 

2017 – 18                    University of Adelaide Early Career Researcher Mentored Project Grant ($14,992)

Project title: Nutrient-gut interactions and glycaemic control in type 2 diabetes.

Tongzhi Wu

 

2017 – 18                    Project Development Grant of the NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health ($32,610)

                                    Project title: Stimulating intestinal bitter taste receptors for control of type 2 diabetes

Tongzhi Wu

 

2017 – 18                    Diabetes Australia Project Grant (Y17G-WUTO) ($59,270)

Project title: Gastrointestinal mechanisms of the anti-diabetic effect of metformin.

Tongzhi Wu, Chris Rayner, Michael Horowitz

 

2017                            University of Adelaide Research Infrastructure Awards ($26,410)

Project title: LOGIQ eR7 Ultrasound System to measure 2D and Doppler ultrasound in nutrition research.

Karen Jones, Chris Rayner Christine Feinle-Bisset, Tongzhi Wu, Stijn Soenen

 

2016 – 17                    RAH Research Foundation Clinical Project Grant ($49,258)

Project title: Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans?

Tongzhi Wu, Chris Rayner

 

2015 – 17                    RAH Research Committee Mary Overton Early Career Fellowship ($252,000)

Project title: The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes

Tongzhi Wu

 

2015                            The University of Adelaide Interdisciplinary Seed Funding ($22,000)

Project title: Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cells.

Jiangbo Zhao, Tongzhi Wu

 

2014 – 16                    RAH Research Foundation Clinical Project Grant ($40,000)

Project title: Intestinal sweet taste receptor control of glucose absorption in human health & type 2 diabetes.

Richard Young, Tongzhi Wu, Chris Rayner

 

2014 – 16                    RAH Research Foundation Clinical Project Grant ($49,700)

Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying.

Karen Jones, Tongzhi Wu, Chris Rayner

 

2014                            Clinical Research Fellowship of NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health ($80,571)

Project title: Gastrointestinal function and the management of type 2 diabetes

Tongzhi Wu

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2025 Principal Supervisor The effects of low-calorie sweeteners on metabolic health in those with or without diabetes mellitus. Doctor of Philosophy Doctorate Full Time Mr Malcolm Joseph Borg
    2022 Principal Supervisor Joint Award Project: Bile Acids and Glycaemia Control in Health and Type 2 Diabetes Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Yixuan Sun

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2023 Principal Supervisor Understanding intestinal and pancreatic hormone secretion in health and type 2 diabetes: (pre-)clinical studies and technical innovations Doctor of Philosophy Doctorate Full Time Dr Weikun Huang
    2017 - 2021 Co-Supervisor The role of gastrointestinal function in the regulation of postprandial glycaemia and energy balance in health and type 2 diabetes Doctor of Philosophy Doctorate Full Time Mr Cong Xie
    2017 - 2019 Co-Supervisor A microfluidic sensing system for simultaneous monitoring of extracellular Ca(II) and insulin secretion Master of Philosophy Master Full Time Dr Weikun Huang

  • Other Supervision Activities
    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2021 - ongoing Principal Supervisor Taste receptor signalling and renal glucose excretion in health and diabetes The University of Adelaide/Southeast University - Doctorate Full Time Ting-ting Li
    2020 - ongoing Principal Supervisor The role of bile acid-gut interaction in glucose homeostasis The University of Adelaide/Southeast University - Doctorate Full Time Chun-jie Xiang
    2019 - ongoing Principal Supervisor Human gut-pancreas chip - a novel in vitro model for diabetes study The University of Adelaide - Higher Doctorate Full Time Weikun Huang
    2019 - ongoing Principal Supervisor Interaction of intestinal bile acids with metformin The University of Adelaide - Honours Full Time Daniel Sansome
    2017 - ongoing Principal Supervisor Effects of nutritive and non-nutritive compounds on gut function, appetite and blood glucose The University of Adelaide - Higher Doctorate Full Time Xuyi Wang
    2017 - 2017 Principal Supervisor Gastrointestinal mechanisms of the anti-diabetic effect of metformin The University of Adelaide - Honours Full Time Malcolm Borg
    2015 - ongoing Principal Supervisor Characterisation of glucose disposal mediated by different gut regions in health and type 2 diabetes The University of Adelaide - Doctorate Full Time Xiang Zhang

  • Mentoring
    Date Topic Location Name
    2022 - ongoing Role of bile acids in metabolic control The University of Adelaide Dr C Xie
    2019 - ongoing Gastrointestinal actions of metformin Ruhr-University Bochum Dr D Quast
    2019 - ongoing Gastrointestinal function in diabetes University of Copenhagen Dr S Veedfald
    2017 - 2017 Gastrointestinal function in diabetes University of Copenhagen Dr S Veedfald
    2015 - ongoing Gastrointestinal function in health and type 2 diabetes The University of Adelaide Dr C Marathe

  • Board Memberships
    Date Role Board name Institution name Country
    2020 - ongoing Board Member Postgraduate Education The University of Adelaide Australia
    2016 - ongoing Advisory Board Member The Global Institute of Traditional Medicine The University of Adelaide Australia

  • Committee Memberships
    Date Role Committee Institution Country
    2019 - ongoing Board Member Chinese Diabetes Society - Translational Research Group Chinese Diabetes Society China
    2016 - ongoing Board Member Centre of Research Excellence in Nutrition Steering Committee The University of Adelaide Australia
    2015 - ongoing Member Australian Diabetes Society - Australia
    2009 - ongoing Member European Association for the Study of Diabetes - -

  • Editorial Boards
    Date Role Editorial Board Name Institution Country
    2023 - ongoing Board Member Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics Wiley-Blackwell United Kingdom
    2022 - ongoing Editor Nutrients Nutrients Switzerland
    2021 - 2022 Editor Frontiers in Physiology Frontiers Switzerland
    2020 - ongoing Associate Editor Frontiers in Endocrinology Frontiers Switzerland

  • Event Participation
    Date Event Name Event Type Institution Country
    2022 - 2022 2022 International Diabetes Federation (IDF) Congress Conference International Diabetes Federation -
    2022 - 2022 A Hundred Years with Glucagon and a Hundred more Conference Danish Diabetes Academy -
    2020 - 2021 RAH Research Fund Campaign Social event Royal Adelaide Hospital -
    2013 - ongoing Diabetes SA education sessions Seminars Diabetes SA -

  • Review, Assessment, Editorial and Advice
    Date Title Type Institution Country
    2022 - 2023 MRFF Grant assessment Grant Assessment NHMRC -
    2022 - 2022 NHMRC Ideas Grant Assessment Grant Assessment NHMRC -
    2021 - 2023 NHMRC Ideas Grant Grant Assessment NHMRC -
    2020 - ongoing Austrian Science Fund grant assessment Grant Assessment Austrian Science Fund -
    2020 - ongoing New Zealand Health Research Council grant assessment Grant Assessment New Zealand Health Research Council -
    2019 - ongoing National Natural Science Foundation of China grant assessment Grant Assessment National Nature Science Foundation of China -
    2018 - ongoing French National Research Agency grant assessment Grant Assessment French National Research Agency -
    2017 - ongoing Australiasian Diabetes Congress Conference Review Australian Diabetes Society -
    2014 - ongoing Diabetes UK grant assessment Grant Assessment Diabetes UK -
  • Position: Ext-Funded Research Fellow (D)
  • Phone: 83136535
  • Email: tongzhi.wu@adelaide.edu.au
  • Fax: 82233870
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 6
  • Org Unit: Medical Specialties
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