Dr Tongzhi Wu

Tongzhi Wu
Adelaide Medical School
Faculty of Health and Medical Sciences

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Dr Tongzhi Wu

Dr Tongzhi Wu is an early-career research fellow within the NHMRC Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, at the University of Adelaide. His major research interest concerns gastrointestinal physiology and glycaemic control in type 2 diabetes. His research is clinically based, and has yielded important insights into the impact of gastric emptying on postprandial blood glucose regulation, the pathophysiology of the ‘incretin’ hormones (ie. glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)), and nutrient sensing within the proximal small intestine in type 2 diabetes. Based on the principles of gut physiology, he is also investigating potential dietary and/or pharmacological strategies that modify gut function to improve glycaemic control in type 2 diabetes. 

Appointments

Date Position Institution name
2014 Early Career Postdoctoral Fellow University of Adelaide
2007 - 2009 Basic Physician Trainee Zhongda Hospital Southeast University
2006 - 2007 Intern (First Class) Zhongda Hospital Southeast University

Awards and Achievements

Date Type Title Institution Name Amount
2016 Award Executive Dean's Award for Research Excellence (Early Career Researcher) The University of Adelaide
2016 Award Travel Award University of Adelaide, School of Medicine 2835
2016 Award Travel Award European Association for the Study of Diabetes €1500
2015 Award Travel Grant University of Adelaide, Discipline of Medicine
2015 Recognition Best Poster Australian Diabetes Society
2015 - 2018 Fellowship Early Career Fellowship Royal Adelaide Hospital
2014 Research Award University Doctoral Research Medal University of Adelaide
2013 Recognition Dean's commendation for thesis excellence University of Adelaide
2013 Award Travel Award, Diabetes Congress International Diabetes Federation (IDF)
2013 Fellowship Travelling Fellowship University of Adelaide, Discipline of Medicine 2600
2012 Award Travel Award European Association for the Study of Diabetes €2000
2011 Award Travel Award European Association for the Study of Diabetes €2000
2011 Fellowship Postgraduate Travelling Fellowship University of Adelaide 1700
2010 Recognition Best Poster Presentation University of Adelaide, Research Expo
2009 - 2013 Scholarship Postgraduate Supplementary Scholarship Centre of Research Excellence in Translating Nutritional Science to Good Health
2009 - 2013 Scholarship Postgraduate Scholarship China Scholarship Council
2009 Recognition Outstanding Postgraduate in Clinical Medicine Southeast University
2007 - 2009 Scholarship First-class postgraduate scholarship Southeast University
2007 Recognition Outstanding Graduate in Clinical Medicine Southeast University
2006 Recognition 'Excellent Student Researcher' in the Student Research Training Program (SRTP) Southeast University
2004 Scholarship 'Zi-guang' Scholarship Southeast University

Education

Date Institution name Country Title
2009 - 2013 University of Adelaide Australia Doctor of Philosophy
2007 - 2009 Southeast University China Master of Clinical Medicine
2002 - 2007 Southeast University China Bachelor of Clinical Medicine

Journals

Year Citation
2017 Wu, T., Horowitz, M. & Rayner, C. (2017). New insights into the anti-diabetic actions of metformin: from the liver to the gut. Expert Review of Gastroenterology and Hepatology, 11, 2, 157-166.
10.1080/17474124.2017.1273769
2017 Wu, T., Trahair, L., Little, T., Bound, M., Zhang, X., Wu, H. ... Jones, K. (2017). Effects of vildagliptin and metformin on blood pressure and heart rate responses to small intestinal glucose in type 2 diabetes.. Diabetes Care, 40, 5, 702-705.
10.2337/dc16-2391
2017 Wu, T., Rayner, C., Watson, L., Jones, K., Horowitz, M. & Little, T. (2017). Comparative effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males. Peptides, 95, 124-127.
10.1016/j.peptides.2017.08.001
2017 Thazhath, S., Marathe, C., Wu, T., Chang, J., Khoo, J., Kuo, P. ... Rayner, C. (2017). Acute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetes. Diabetes and Vascular Disease Research, 14, 1, 59-63.
10.1177/1479164116666761
2017 Wu, T., Xie, C., Wu, H., Jones, K., Horowitz, M. & Rayner, C. (2017). Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes, Obesity and Metabolism, 19, 2, 290-293.
10.1111/dom.12812
2017 Rayner, C., Jones, K., Wu, T. & Horowitz, M. (2017). Gut feelings about diabetes and GLP-1 receptor agonists: lessons to be learnt from studies in functional gastrointestinal disorders. Diabetes, Obesity and Metabolism, 19, 3, 309-312.
10.1111/dom.12822
2016 Wu, T., Little, T., Bound, M., Borg, M., Zhang, X., Deacon, C. ... Rayner, C. (2016). A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes. Diabetes Care, 39, 4, 511-517.
10.2337/dc15-2298
2016 Zhang, X., Liu, T., Wang, Y., Zhong, M., Zhang, G., Liu, S. ... Hu, S. (2016). Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats. Obesity Surgery, 26, 7, 1565-1575.
10.1007/s11695-015-1925-y
2016 Rigda, R., Trahair, L., Little, T., Wu, T., Standfield, S., Feinle-Bisset, C. ... Jones, K. (2016). Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects. Peptides, 86, 126-132.
10.1016/j.peptides.2016.10.010
2016 Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K. ... Rayner, C. (2016). Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. American Journal of Clinical Nutrition, 103, 1, 66-70.
10.3945/ajcn.115.117440
2016 Thazhath, S., Marathe, C., Wu, T., Chang, J., Khoo, J., Kuo, P. ... Rayner, C. (2016). The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal motility, flow, transit, and absorption of glucose in healthy subjects and patients with type 2 diabetes: a randomized controlled trial. Diabetes, 65, 1, 269-275.
10.2337/db15-0893
2016 Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, C. ... Rayner, C. (2016). Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 101, 12, 4769-4778.
10.1210/jc.2016-2813
2016 Horowitz, M., Wu, T., Deane, A., Jones, K. & Rayner, C. (2016). DPP-4 inhibition and the known unknown. Diabetes, 65, 8, 2124-2126.
10.2337/dbi16-0023
2016 Chen, C., Hu, B., Wu, T., Zhang, Y., Xu, Y., Feng, Y. & Jiang, H. (2016). Bile acid profiles in diabetic (db/db) mice and their wild type littermates. Journal of Pharmaceutical and Biomedical Analysis, 131, 473-481.
10.1016/j.jpba.2016.09.023
2016 Wu, T., Rayner, C. & Horowitz, M. (2016). Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control. Biomarkers in Medicine, 10, 11, 1167-1179.
10.2217/bmm-2016-0164
2016 Thazhath, S., Wu, T., Bound, M., Checklin, H., Standfield, S., Jones, K. ... Rayner, C. (2016). Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: a randomised controlled trial. Nutrition, 32, 5, 553-559.
10.1016/j.nut.2015.11.004
2015 Yang, B., Lu, Y., He, J., Wu, T., Xie, Z., Lei, C. ... Sun, Z. (2015). Performance of fasting plasma glucose and postprandial urine glucose in screening for diabetes in Chinese high‑risk population. Chinese Medical Journal, 128, 24, 3270-3275.
10.4103/0366-6999.171353
2015 Wu, T., Trahair, L., Bound, M., Deacon, C., Horowitz, M., Rayner, C. & Jones, K. (2015). Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?. Diabetic Medicine, 32, 5, 595-600.
10.1111/dme.12622
2015 Wu, T., Thazhath, S., Marathe, C., Bound, M., Jones, K., Horowitz, M. & Rayner, C. (2015). Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Sebastian Thazhath, S (Ed.). Nutrition and Diabetes, 5, 5, e156-1-e156-4.
10.1038/nutd.2015.6
2015 Mignone, L. E., Wu, T., Horowitz, M. & Rayner, C. K. (2015). Whey protein: The "whey" forward for treatment of type 2 diabetes?. World journal of diabetes, 6, 14, 1274-1284.
10.4239/wjd.v6.i14.1274
2014 Thazhath, S., Wu, T., Bound, M., Checklin, H., Jones, K., Willoughby, S. ... Rayner, C. (2014). Changes in meal composition and duration affect postprandial endothelial function in healthy humans. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, 12, G1191-G1197.
10.1152/ajpgi.00323.2014
2014 Wu, T., Thazhath, S., Bound, M., Jones, K., Horowitz, M. & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?. Diabetes Research and Clinical Practice, 106, 1, e3-e6.
10.1016/j.diabres.2014.08.004
2014 Wu, T., Ma, J., Bound, M., Checklin, H., Deacon, C., Jones, K. ... Rayner, C. (2014). Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin. Diabetes, 63, 8, 2776-2787.
10.2337/db13-1627
2014 Thazhath, S., Wu, T., Young, R., Horowitz, M. & Rayner, C. (2014). Glucose absorption in small intestinal diseases. Expert Review of Gastroenterology and Hepatology, 8, 3, 301-312.
10.1586/17474124.2014.887439
2013 Wu, T., Bound, M., Zhao, R., Standfield, S., Bellon, M., Jones, K. ... Rayner, C. (2013). Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care, 36, 7, 1913-1918.
10.2337/dc12-2294
2013 Chang, J., Wu, T., Greenfield, J., Samocha-Bonet, D., Horowitz, M. & Rayner, C. (2013). Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes. Diabetes Care, 36, 8, 2262-2265.
10.2337/dc12-1663
2013 Wu, T., Rayner, C., Young, R. & Horowitz, M. (2013). Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology, 13, 6, 928-934.
10.1016/j.coph.2013.09.002
2013 Wu, T., Bound, M., Standfield, S., Gedulin, B., Jones, K., Horowitz, M. & Rayner, C. (2013). Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes Obesity & Metabolism, 15, 5, 474-477.
10.1111/dom.12043
2013 Wu, T., Bound, M., Standfield, S., Bellon, M., Young, R., Jones, K. ... Rayner, C. (2013). Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care, 36, 12, e202-e203.
10.2337/dc13-0958
2013 Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T. ... Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62, 10, 3532-3541.
10.2337/db13-0581
2013 Wu, T., Bound, M., Standfield, S., Jones, K., Horowitz, M. & Rayner, C. (2013). Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans. Journal of Clinical Endocrinology and Metabolism, 98, 4, 718-722.
10.1210/jc.2012-3961
2012 Wu, T., Zhao, R., Bound, M., Checklin, H., Bellon, M., Little, T. ... Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. American Journal of Clinical Nutrition, 95, 1, 78-83.
10.3945/ajcn.111.021543
2010 Wu, T., Rayner, C. K., Jones, K. & Horowitz, M. (2010). Dietary effects on incretin hormone secretion.. Vitam Horm, 84, 81-110.
10.1016/B978-0-12-381517-0.00003-5

Book Chapters

Year Citation
2016 Wu, T., Rayner, C. K. & Horowitz, M. (2016). Incretins. In S. Herzig (Ed.), Metabolic Control (pp. 137-171). Switzerland: Springer.
10.1007/164_2015_9

Conference Papers

Year Citation
2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz, , Jones, K. L. & Rayner, C. K. (2015). Effects of Glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on small intestinal motility, and glucose absorption in health and type 2 diabetes. Australian Diabetes Society. Adelaide.
2015 Marathe, C., Thazhath, S. S., Wu, T., Horowitz, M., Jones, K. L. & Rayner, C. K. (2015). Effects of glucagon-like peptide -1 (GLP-1) receptor agonist, exenatide, on blood pressure and heart rate during duodenal glucose infusion in type 2 diabetes. Australian Diabetes Society. Adelaide.
2012 Zhao, R., Wu, T., Jones, K., Horowitz, M. & Rayner, C. (2012). Effects of a D-xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in patients with type 2 diabetes. Australian Gastroenterology Week. Adelaide.
10.1111/j.1440-1746.2011.07251_9.x
2012 Bound, M., Wu, T., Gedulin, B., Horowitz, M. & Rayner, C. (2012). Effects of bile acid enemas on GLP-1 and PYY secretion in healthy humans. Annual Meeting of the European Association for the Study of Diabetes. Berlin.
10.1007/s00125-012-2688-9
2011 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T. ... Rayner, C. (2011). Effects of different sweet preloads on incretin hormone responses, gastric emptying and postprandial glycaemia in healthy humans. 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2010 Ma, J., Wu, T., Checklin, H., Wishart, J., Stevens, J., Jones, K. ... Rayner, C. (2010). Effects of enterically coated, nutrient-containing pellets on glycaemia and incretin hormone release in type 2 diabetes.
2010 Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T. ... Rayner, C. (2010). Effects of sweet preloads on gastric emptying and postprandial glycaemia in healthy subjects.

Conference Items

Year Citation
2017 Buttfield, M., Stevens, J., Hatzinikolas, S., Wu, T., Pham, H., Lange, K. ... Jones, K. (2017). EFFECTS OF SITAGLIPTIN ON GASTRIC EMPTYING OF, AND THE BLOOD PRESSURE RESPONSE TO, A CARBOHYDRATE MEAL IN TYPE 2 DIABETES.
2017 Jones, K., Rigda, R., Buttfield, M., Hatzinikolas, S., Pham, H., Marathe, C. ... Horowitz, M. (2017). Acute effects of lixisenatide on gastric emptying, glycaemia and 'postprandial' blood pressure responses to an oral glucose load in healthy subjects and type 2 diabetes. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2017 Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N. ... Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2017 Wu, T., Horowitz, M., Jones, K. & Rayner, C. (2017). Endogenous glucagon-like peptide-1 mediates the lowering of glycaemia during small intestinal glucose infusion by bile acids in type 2 diabetes. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2017 Phillips, L., Watson, L., Wu, T., Bound, M., Checklin, H., Grivell, J. ... Rayner, C. (2017). Longitudinal evaluation of gastric emptying in type 2 diabetes. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2017 Rayner, C., Wu, T., Horowitz, M. & Jones, K. (2017). Blockade of glucagon-like peptide-1 receptors by exendin(9-39) attenuates the increase in heart rate during small intestinal glucose infusion in type 2 diabetes. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Lisbon, PORTUGAL.
2016 Zhang, X., Bound, M., Standfield, S., Hu, S., Jones, K., Horowitz, M. ... Wu, T. (2016). Comparative effects of proximal and distal small intestinal glucose on glycaemia, incretin hormone secretion and incretin effect in healthy males. 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD). Munich, GERMANY.
10.1007/s00125-016-4046-9
2016 Wu, T., Zhang, X., Little, T., Bound, M., Standfield, S., Deacon, C. ... Rayner, C. (2016). The rate of intraduodenal glucose delivery affects the lowering of blood glucose by vildagliptin in type 2 diabetes. 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Munich, GERMANY.
2016 Mignone, L., Wu, T., Phillips, L., Bound, M., Checklin, H., Grivell, J. ... Rayner, C. (2016). A whey/guar "preload" improves postprandial glycaemia and HbA(1c) in type 2 diabetes: a 12-week, single-blind, randomised and placebo controlled trial. 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD). Munich, GERMANY.
10.1007/s00125-016-4046-9
2016 Chen, C., Hu, B., Wu, T. & Jiang, H. (2016). Targeted metabolomics study on bile acid profiles in db/db mice and their wild type littermates. 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Munich, GERMANY.
2014 Wu, T., Bound, M., Deacon, C., Jones, K., Horowitz, M. & Rayner, C. (2014). Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?.
2014 Mignone, L., Wu, T., Bound, M., Jones, K., Horowitz, M. & Rayner, C. (2014). A low-dose whey protein preload slows gastric emptying and improves post-prandial glycaemia in type 2 diabetes.
2012 He, J., Sun, Z., Wu, T., Xie, Z., Lu, Y., Lei, C. ... Zhou, Y. (2012). Screening for diabetes and pre-diabetes with combined use of FPG and quantitative postprandial urine glucose in Chinese high-risk population: a community-based study.
2012 Young, R., Chia, B., Wu, T., Michael, H. & Rayner, C. (2012). Loss of intestinal sweet taste receptor control in type 2 diabetes: A risk factor for postprandial hyperglycemia?.
2012 Wu, T., Zhao, B., Horowitz, M., Jones, K. & Rayner, C. (2012). Effects of a xylose preload, with or without sitagliptin, on gastric emptying and postprandial glycaemia in type 2 diabetes.

2017                      Gastrointestinal mechanism of the anti-diabetic effect of metformin. Wu T, Rayner CK & Horowitz M. Diabetes Australia. ($59,270)

2016-17                 Does intestinal bitter taste sensing modulate gastrointestinal motility and hormone secretion to reduce glycaemia and energy intake in humans? Wu T & Rayner CK. Royal Adelaide Hospital Research Foundation. ($49,258)

2015-17                The “gut-incretin” axis in the regulation of postprandial glycaemia in type 2 diabetes. Wu T. Royal Adelaide Hospital Research Foundation. ($252,000)

2015-16                Fibre insight in diabetes treatment: a new photonic fibre device to investigate the enteroendocrine L-cell. Zhao J & Wu T. The University of Adelaide. ($22,000)

2014-15                 AstraZeneca sponsored investigator initiated study – Project title: Combining saxagliptin and acarbose to improve postprandial hyperglycaemia in type 2 diabetes. Wu T & Sun Z. ($ 100,000)

2014-16                 Royal Adelaide Hospital Research Foundation – Project title: Effects of DPP-4 inhibition with sitagliptin on postprandial blood pressure, glycaemia and incretin hormones in type 2 diabetes – relationship to gastric emptying. Jones KL, Wu T, and Rayner CK. ($47,700)

2014-16                 Royal Adelaide Hospital Research Foundation – Project title: Sweet taste receptor control of glucose absorption in human health & type 2 diabetes. Young RL, Wu T, Rayner CK. ($40,000)

Committee Memberships

Date Role Committee Institution Country
2015 - ongoing Member Australian Diabetes Society Australia
2009 - ongoing Member European Association for the Study of Diabetes
Phone
0882225038
Fax
8223 3870
Campus
North Terrace
Building
RAH - Eleanor Harrald
Room Number
6 21
Org Unit
Medical Specialties

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