Cong Xie

Cong Xie

Higher Degree by Research Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences


Dr Cong Xie was a top-ranked medical graduate of Southeast University (Nanjing, China) in 2017. Subsequent to the completion of his physician training in a tertiary hospital in Nanjing (2014-17), he was awarded a prestigious PhD scholarship jointly funded by the China Scholarship Council and The University of Adelaide. In the latter, he conducted a highly productive PhD study, focussing on the understanding of the important role of the gut in glucose metabolism in both health and type 2 diabetes and translation of these novel insights into improved therapy for type 2 diabetes. He is passionate about these research areas and, with strong support from mentors of internationally recognised expertise in the field, committed to pursue an independent research career in Adelaide.

Type 2 diabetes is a leading cause of blindness, amputations, heart disease and kidney disease. Up to a third of Australians will develop type 2 diabetes in their lifespan, which can impose a ~6 years decrease in life expectancy and a 3-4 fold increase in healthcare costs within Australia. As the key interface between ingested nutrients and the body, the gastrointestinal tract is now recognised to play a central role in regulating postprandial metabolism. Dr Xie's research focuses on the pivotal role of gastrointestinal (GI) function, particularly gastric emptying and GI hormones (e.g. glucagon-like peptide-1 (GLP-1)), in the regulation of postprandial glycaemia, energy expenditure and energy intake in both health and type 2 diabetes (T2D). He is particularly interested in the role of bitter taste and bile acid signalling in the metabolic homeostasis.

During the PhD program, he has been actively involved in over 10 clinical research projects and responsible for driving 9 clinical studies relating to gastrointestinal function and metabolic control in health and type 2 diabetes during his PhD. With the great support from his supervisors (Prof Chris Rayner and A/Prof Tongzhi Wu), he is now determining: the roles of bitter taste and bile acid signalling in the regulation of gastrointestinal function, energy intake and postprandial glycaemia in cohorts of healthy participants and patients with T2D. These studies would provide clear views of the physiology and pathophysiology of T2D and have a high potential to establish novel, safe and cost-effective strategies to improve the management of T2D.

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  • Appointments

    Date Position Institution name
    2021 Clinical Research Fellow University of Adelaide
    2015 - 2017 Physician Trainee Zhongda Hospital Southeast University
    2014 - 2015 Intern Southeast University
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2021 Award Adelaide Medical School Research Support Award The University of Adelaide Australia
    2021 Award Australia Diabetes Society Registration Grant Australia Diabetes Society Australia
    2020 Award Clinical Poster Award (Finalist) Australia Diabetes Society Australia
    2019 Award Travel Grant European Association for the Study of Diabetes Italy
    2018 Award Travel Grant European Association for the Study of Diabetes Italy
    2018 Achievement Clinical Poster Award (Finalist) Australia Diabetes Society Australia
    2018 Award The Hospital Research Foundation Research Travel Awards The Hospital Research Foundation Australia
    2018 Award Adelaide Medical School Research Travel Award The University of Adelaide Australia
    2018 Scholarship Postgraduate Supplementary Scholarship National Health and Medical Research Council Grant Australia
    2017 Scholarship Postgraduate scholarship China Scholarship Council China
  • Education

    Date Institution name Country Title
    2017 - 2021 University of Adelaide Australia PhD
    2015 - 2017 Southeast University China Master
    2010 - 2015 Southeast University China Bachelor
  • Research Interests

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  • Journals

    Year Citation
    2021 Xie, C., Huang, W., Wang, X., Trahair, L. G., Pham, H. T., Marathe, C. S., . . . Wu, T. (2021). Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink. Diabetes Research and Clinical Practice, 171, 1-8.
    DOI Scopus1 WoS1
    2021 Xie, C., Huang, W., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021). Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease. Nutrients, 13(4), 1-16.
    DOI Scopus5 WoS5 Europe PMC2
    2021 Borg, M. J., Xie, C., Rayner, C. K., Horowitz, M., Jones, K. L., & Wu, T. (2021). Potential for gut peptide‐based therapy in postprandial hypotension. Nutrients, 13(8), 2826-1-2826-14.
    DOI
    2021 Huang, W., Wu, T., Xie, C., Rayner, C. K., Priest, C., Ebendorff-Heidepriem, H., & Zhao, J. (2021). Sensing Intra- and Extra-Cellular Ca<sup>2+</sup> in the Islet of Langerhans. Advanced Functional Materials, 24 pages.
    DOI
    2021 Xie, C., Huang, W., Watson, L. E., Soenen, S., Young, R. L., Jones, K. L., . . . Wu, T. (2021). Plasma GLP-1 response to oral and intraduodenal nutrients in health and type 2 diabetes - impact on gastric emptying.. J Clin Endocrinol Metab.
    DOI
    2020 Sansome, D. J., Xie, C., Veedfald, S., Horowitz, M., Rayner, C. K., & Wu, T. (2020). Mechanism of glucose-lowering by metformin in type 2 diabetes: role of bile acids. Diabetes, Obesity and Metabolism, 22(2), 141-148.
    DOI Scopus21 WoS19 Europe PMC8
    2020 Xie, C., Wang, X., Jones, K. L., Horowitz, M., Sun, Z., Little, T. J., . . . Wu, T. (2020). Role of endogenous glucagon-like peptide-1 enhanced by vildagliptin in the glycaemic and energy expenditure responses to intraduodenal fat infusion in type 2 diabetes. Diabetes, obesity & metabolism, 22(3), 383-392.
    DOI Scopus5 WoS4 Europe PMC2
    2020 Wang, X., Xie, C., Marathe, C. S., Malbert, C. -H., Horowitz, M., Jones, K. L., . . . Wu, T. (2020). Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes.. Diabetes research and clinical practice, 159, 107951.
    DOI Scopus3 WoS3 Europe PMC1
    2020 Borg, M. J., Rayner, C. K., Jones, K. L., Horowitz, M., Xie, C., & Wu, T. (2020). Gastrointestinal mechanisms underlying the cardiovascular effect of metformin. Pharmaceuticals, 13(11), 1-14.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Wu, T., Rayner, C. K., Jones, K. L., Xie, C., Marathe, C., & Horowitz, M. (2020). Role of intestinal glucose absorption in glucose tolerance. Current Opinion in Pharmacology, 55, 116-124.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Xie, C., Wang, X., Jones, K. L., Horowitz, M., Sun, Z., Little, T. J., . . . Wu, T. (2020). Comparative effects of intraduodenal glucose and fat infusion on blood pressure and heart rate in type 2 diabetes. Frontiers in Nutrition, 7, 1-6.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Wang, X., Xie, C., Sun, Z., & Wu, T. (2020). Role of intestinal bile acids in the regulation of metabolic homeostasis in humans. Chinese Journal of Diabetes Mellitus, 12(4), 272-274.
    DOI
    2020 Huang, W., Xie, C., Young, R. L., Zhao, J., Ebendorff-Heidepriem, H., Jones, K. L., . . . Wu, T. (2020). Development of innovative tools for investigation of nutrient-gut interaction. World Journal of Gastroenterology, 26(25), 3562-3576.
    DOI Scopus1 WoS1
    2020 Xie, C., Jones, K. L., Rayner, C. K., & Wu, T. (2020). Enteroendocrine hormone secretion and metabolic control: importance of the region of the gut stimulation. Pharmaceutics, 12(9), 1-23.
    DOI Scopus7 WoS7 Europe PMC2
    2019 Watson, L. E., Xie, C., Wang, X., Li, Z., Phillips, L. K., Sun, Z., . . . Wu, T. (2019). Gastric emptying in patients with well-controlled type 2 diabetes compared with young and older control subjects without diabetes. Journal of Clinical Endocrinology and Metabolism, 104(8), 3311-3319.
    DOI Scopus22 WoS18 Europe PMC6
    2018 Xie, C., Wang, X., Young, R. L., Horowitz, M., Rayner, C. K., & Wu, T. (2018). Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control. Frontiers in Endocrinology, 9, 576-1-576-10.
    DOI Scopus28 WoS25 Europe PMC10
    2017 Wu, T., Xie, C., Wu, H., Jones, K., Horowitz, M., & Rayner, C. (2017). Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes. Diabetes, Obesity and Metabolism, 19(2), 290-293.
    DOI Scopus31 WoS30 Europe PMC21
  • Conference Items

    Year Citation
    2020 Wu, T., Wang, X., Xie, C., Marathe, C. S., Malbert, C. -H., Horowitz, M., . . . Sun, Z. (2020). Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
    2020 Wang, X., Chen, C., Xie, C., Horowitz, M., Jones, K. L., Rayner, C. K., . . . Wu, T. (2020). Serum bile acids after an oral glucose load in Chinese healthy individuals and patients with type 2 diabetes: relationships with glycaemia. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Xie, C., Wang, X., Bound, M. J., Young, R. L., Jones, K. L., Horowitz, M., . . . Wu, T. (2020). Bitter taste signalling modulates bile acid-induced PYY, but not GLP-1 secretion in healthy humans. Poster session presented at the meeting of Abstracts of the 56th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Virtual Online: Springer-Verlag.
    DOI
    2020 Wu, T., Xie, C., Wang, X., Bound, M. J., Grivell, J., Jones, K. L., . . . Rayner, C. K. (2020). Role of endogenous glucagon-like peptide-1 in the serum triglyceride response to intraduodenal fat infusion in type 2 diabetic patients on vildagliptin. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2020 Sansome, D., Veedfald, S., Xie, C., Bound, M., Grivell, J., Jones, K., . . . Wu, T. (2020). Role of bile acids on glucose-lowering by metformin in type 2 diabetes. Poster session presented at the meeting of DIABETOLOGIA. ELECTR NETWORK: SPRINGER.
    2019 Xie, C., Wang, X., Bound, M., Grivell, J., Jones, K., Horowitz, M., . . . Wu, T. (2019). Roles of endogenous GLP-1 in the glycaemic and energy expenditure responses to fat in type 2 diabetes studied using vildagliptin and exendin(9-39). Poster session presented at the meeting of DIABETOLOGIA. Barcelona, SPAIN: SPRINGER.
    2019 Horowitz, M., Xie, C., Wang, X., Bound, M. J., Grivell, J., Jones, K. L., . . . Wu, T. (2019). Comparative effects of intraduodenal glucose and fat on blood pressure and heart rate in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), as published in Diabetologia. Barcelona, SPAIN: Springer-Verlag.
    DOI
    2018 Xie, C., Wang, X., Bound, M., Grivell, J., Young, R., Jones, K., . . . Wu, T. (2018). Effects of the bitter taste receptor agonist, denatonium benzoate, on postprandial glycaemia, gastric emptying and energy intake in type 2 diabetes. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
    DOI

Dr Xie has supervised five medical undergraduates on research placement and summer scholarship projects. He has provided technical training to a number of Honours students and junior HDR students within his research centre.

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  • Memberships

    Date Role Membership Country
    2018 - ongoing Member Australian Diabetes Society Australia
    2018 - ongoing Member European Association for the Study of Diabetes Italy

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