Weikun Huang
Health and Medical Sciences Faculty Office
Faculty of Health and Medical Sciences
Weikun's work focuses on developing organ-on-chip platform for studying the endocrine functions of gut and pancreas and the identification of novel therapeutic targets for type 2 diabetes (T2D). He is also interested in understanding the gut and pancreatic hormone secretion in health and T2D.
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Appointments
Date Position Institution name 2023 - ongoing Grant-funded researcher University of Adelaide 2019 - 2023 PhD candidate The University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2023 Award Travel Grant Australian Diabetes Society Australia 350 2023 Award Pincus Taft Young Investigator Award (Finalist) Australian Diabetes Society Australia - 2023 Award Travel Grant European Association for the Study of Diabetes Germany €2,000 2022 Award Travel Grant European Association of the Study of Diabetes Germany €1,400 2022 Award Clinical Poster Award (Finalist) Australian Diabetes Society Australia - 2022 Award Basic Science Poster Award (Finalist) Australian Diabetes Society Australia - 2022 Research Award Travel Grant Adelaide Graduate and Research School, The University of Adelaide Australia 2,500 2022 Research Award Adelaide Medical School Travel Grant Adelaide Medical School, The University of Adelaide Australia 3,500 2022 Award Best Student Paper Award Institute of Photonics and Advanced Sensing Australia 500 2022 Award Travel Award Australian Diabetes Society Australia 700 2021 Award Best Transdisciplinary Paper Award Institute of Photonics and Advanced Sensing, The University of Adelaide Australia 500 2020 Award ADS-Abbott Registration Grant Australian Diabetes Society Australia 250 2020 Award Pincus Taft Young Investigator Award (Finalist) Australian Diabetes Society Australia - 2019 Award People's Choice for Best Oral Presentation Institute of Photonics and Advanced Sensing, The University of Adelaide Australia - 2019 Scholarship NHMRC-funded supplementary scholarship The University of Adelaide Australia 5,000 per annum 2019 Scholarship Adelaide Graduate Research Scholarship The University of Adelaide Australia 32,500 per annum 2019 Award Travel Award ARC Centre of Excellence for Nanoscale BioPhotonics, The University of Adelaide Australia - -
Language Competencies
Language Competency Chinese (Mandarin) Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title Jilin University China Bachelor's degree in Agriculture (Veterinary Medicine) Jilin University China Bachelor's degree in Art (English), dual degree The University of Adelaide Australia Master of Philosophy in Physics The University of Adelaide Australia Doctor of Philosophy in Medicine -
Research Interests
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Journals
Year Citation 2024 Huang, W., O’Hara, S. E., Xie, C., Liu, N., Rayner, C. K., Nicholas, L. M., & Wu, T. (2024). Effects of a bitter substance, denatonium benzoate, on pancreatic hormone secretion. American Journal of Physiology - Endocrinology and Metabolism, 326(4), E537-E544.
2024 Xie, C., Iroga, P., Bound, M. J., Grivell, J., Huang, W., Jones, K. L., . . . Wu, T. (2024). Impact of the timing of metformin administration on glycaemic and glucagon-like peptide-1 responses to intraduodenal glucose infusion in type 2 diabetes: a double-blind, randomised, placebo-controlled, crossover study. Diabetologia, 67(7), 1260-1270.
2024 Xiang, C., Sun, Y., Luo, Y., Xie, C., Huang, W., Sun, Z., . . . Wu, T. (2024). Gastric emptying of a glucose drink is predictive of the glycaemic response to oral glucose and mixed meals, but unrelated to antecedent glycaemic control, in type 2 diabetes. Nutrition and Diabetes, 14(1), 13-1-13-7.
Scopus12024 Xiang, C., Sun, Y., Luo, Y., Xie, C., Huang, W., Jones, K. L., . . . Wu, T. (2024). Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia. Diabetes, Obesity and Metabolism, 26(8), 3119-3127.
Scopus12024 Sun, Y., Luo, Y., Xiang, C., Xie, C., Huang, W., Sun, Z., . . . Wu, T. (2024). Gastric emptying in newly diagnosed, treatment-naïve Han Chinese with type 2 diabetes and the impact of 4-week insulin pump therapy. Diabetes, Obesity and Metabolism, 26(8), 3078-3087.
2024 Xie, C., Huang, W., Rayner, C. K., Horowitz, M., & Wu, T. (2024). Letter to the Editor From Xie et al: "The <SUP>13</SUP>C Glucose Breath Test Accurately Identifies Insulin Resistance in People With Type 1 Diabetes". JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2 pages.
2024 Huang, W., Xie, C., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2024). Sex differences in the plasma glucagon responses to a high carbohydrate meal and a glucose drink in type 2 diabetes. Diabetes Research and Clinical Practice, 214, 3 pages.
2023 Huang, W., Xie, C., Wewer Albrechtsen, N. J., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2023). The 'early' postprandial glucagon response is related to the rate of gastric emptying in patients with type 2 diabetes. Peptides, 161, 170941-1-170941-7.
Scopus4 WoS12023 Xie, C., Jalleh, R. J., Watson, L. E., Huang, W., Sun, Y., Jones, K. L., . . . Wu, T. (2023). Determinants of blood glucose concentrations following a high carbohydrate meal in type 2 diabetes: A multiple linear regression analysis. Diabetes Research and Clinical Practice, 198, 110606.
Scopus3 Europe PMC12023 Xie, C., Huang, W., Sun, Y., Xiang, C., Trahair, L., Jones, K. L., . . . Wu, T. (2023). Disparities in the glycaemic and incretin responses to intraduodenal glucose infusion between healthy young men and women.. The Journal of clinical endocrinology and metabolism, 108(9), e712-e719.
Scopus11 WoS2 Europe PMC52023 Huang, W., Xie, C., Wewer Albrechtsen, N. J., Sang, M., Sun, Z., Jones, K. L., . . . Wu, T. (2023). Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes. Peptides, 169, 171092-1-171092-10.
Scopus22022 Huang, W., Wu, T., Xie, C., Rayner, C. K., Priest, C., Ebendorff-Heidepriem, H., & Zhao, J. (2022). Sensing Intra- and Extra-Cellular Ca2+ in the Islet of Langerhans. Advanced Functional Materials, 32(3), 24 pages.
Scopus22022 Xie, C., Huang, W., Watson, L. E., Soenen, S., Young, R. L., Jones, K. L., . . . Wu, T. (2022). Plasma GLP-1 response to oral and intraduodenal nutrients in health and type 2 diabetes - impact on gastric emptying. The Journal of Clinical Endocrinology & Metabolism, 107(4), e1643-e1652.
Scopus20 WoS11 Europe PMC122022 Wang, X., Chen, C., Xie, C., Huang, W., Young, R. L., Jones, K. L., . . . Wu, T. (2022). Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2h plasma glucose in individuals without diabetes.. Diabetes, obesity & metabolism, 24(6), 1134-1142.
Scopus7 WoS6 Europe PMC62021 Xie, C., Huang, W., Wang, X., Trahair, L. G., Pham, H. T., Marathe, C. S., . . . Wu, T. (2021). Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink. Diabetes Research and Clinical Practice, 171, 1-8.
Scopus17 WoS9 Europe PMC62021 Xie, C., Huang, W., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021). Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease. Nutrients, 13(4), 1-16.
Scopus57 WoS44 Europe PMC382021 Palasis, K. A., Lokman, N. A., Quirk, B. C., Adwal, A., Scolaro, L., Huang, W., . . . Abell, A. D. (2021). Optical fibre-enabled photoswitching for localised activation of an anti-cancer therapeutic drug. International Journal of Molecular Sciences, 22(19), 10844-1-10844-10.
Scopus5 WoS3 Europe PMC22020 Huang, W., Wu, T., Shallan, A., Kostecki, R., Rayner, C. K., Priest, C., . . . Zhao, J. (2020). A multiplexed microfluidic platform towards interrogating endocrine function: simultaneous sensing of extracellular Ca²⁺ and hormone. ACS Sensors, 5(2), 490-499.
Scopus6 WoS4 Europe PMC22020 Huang, W., Xie, C., Young, R. L., Zhao, J., Ebendorff-Heidepriem, H., Jones, K. L., . . . Wu, T. (2020). Development of innovative tools for investigation of nutrient-gut interaction. World Journal of Gastroenterology, 26(25), 3562-3576.
Scopus8 WoS7 Europe PMC32016 Deng, Q., Ma, D., Shi, Z., Huang, W., Du, X., Gao, W., . . . Li, X. (2016). Effects of β-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes in vitro. Journal of Animal Physiology and Animal Nutrition, 100(2), 331-336.
Scopus1 WoS12015 Li, X., Huang, W., Gu, J., Du, X., Lei, L., Yuan, X., . . . Liu, G. (2015). SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver. Cellular Signalling, 27(10), 2099-2109.
Scopus105 WoS94 Europe PMC44
2024 UK Reserach and Innovation Grant (£161,994)
Project Title: Sensing and signalling of extracellular Ca2+ in the islet of Langerhans
Chief Investigators: Jiangbo Zhao, Weikun Huang
2023 Diabetes Australia Project Grant (ID: Y24G-XIEC) ($59,995)
Project title: Development of a novel bile acid-based therapy to optimise postprandial glycaemic control in type 2 diabetes
Chief Investigators: Cong Xie, Tongzhi Wu, Richard Young, Michael Horowitz, Weikun Huang
2023 Diabetes Australia Project Grant (ID: Y23G-WUTO) ($70,000)
Project title: Harnessing bile acid sensing mechanisms to improve the management of type 2 diabetes.
Chief Investigators: Tongzhi Wu, Chris Rayner, Richard Young, Michael Horowitz, Karen Jones, Cong Xie, Heike Ependorff-Heidepriem, Weikun Huang
2023 Diabetes Australia Project Grant (ID: Y23G-RAYN) ($70,000)
Project title: Impact of renal 'sweet taste' sensing on the risk of dysglycaemia.
Chief Investigators: Chris Rayner, Tongzhi Wu, Richard Young, Merlin Thomas, Cong Xie, Weikun Huang
2022 Faculty of Health and Medical Sciences Strategic Research Support, The University of Adelaide ($32,600)
Project title: Application of a novel “organ-on-a-chip” system to understand the role of bitter taste in the regulation of the gut-pancreas axis
Chief Investigators: Tongzhi Wu, Lisa Nicholas, Weikun Huang, Chris Rayner, Heike Ebedorff-Heidepriem
2021 University of Adelaide, Faculty of Health and Medical Sciences - 2021 Small Equipment funding Award – Microfluidic perfusion pump ($2,470).
Tongzhi Wu, Richard Young, Lisa Nicholas, Weikun Huang
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Mentoring
Date Topic Location Name 2021 - 2022 Profiling the glucagon-like peptide-1 (GLP-1) secretion from the mouse intestinal tissue ex vivo The University of Adelaide Health science undergraduate students
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Memberships
Date Role Membership Country 2021 - ongoing Member European Association for the Study of Diabetes Germany 2020 - ongoing Member Australian Diabetes Society Australia
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