Dr Scott Clark

Scott Clark
Clinical Academic
Adelaide Medical School
Faculty of Health and Medical Sciences

Scott a Clinical Academic for the University of Adelaide Discipline of Psychiatry based in the Central Local Health Network and works as a consultant psychiatrist in the Western Community Mental Health Service.
He is the Chair of the metropolitan Adelaide Clozapine Working Group responsible for quality interventions in clozapine care systems. Scott completed a BSc in Psychology at Flinders University in 1994, followed by an Honours in Medical Science at the Centre for Neuroscience at Flinders University in 1995. He went on to study medicine in Adelaide completing his MBBS in 2004, and followed with a PhD in Health Informatics at Adelaide University during which he was supported by a NHMRC Dora Lush Postgraduate Scholarship. His PhD thesis focussed on the development of computer-based alerting systems designed to improve the quality of health care.

Investigator, cognitive function and mood disorders (CoFaMS) and Cognitive and
Functional Assessment of Psychosis Staging Study (CoFAPSS) studies, with an emphasis on recruitment and assessment of patients with chronic psychosis (CoFAPPs) and lithium treated patients (CoFaMS, ConLiGen international consortium); Predictive modeling of symptom and function trajectories in mental illness (transition to first psychotic episode, treatment resistant psychosis); Pharmacogenetics and prediction of response to lithium and clozapine. Health service data linkage studies of patients with chronic psychosis; investigator in the recently established Adelaide Integrated Mental Health Biobank and Disease Marker Centre.

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Dr Scott Clark

Scott a Clinical Academic for the University of Adelaide Discipline of Psychiatry based in the Central Local Health Network and works as a consultant psychiatrist in the Western Community Mental Health Service.
He is the Chair of the metropolitan Adelaide Clozapine Working Group responsible for quality interventions in clozapine care systems. Scott completed a BSc in Psychology at Flinders University in 1994, followed by an Honours in Medical Science at the Centre for Neuroscience at Flinders University in 1995. He went on to study medicine in Adelaide completing his MBBS in 2004, and followed with a PhD in Health Informatics at Adelaide University during which he was supported by a NHMRC Dora Lush Postgraduate Scholarship. His PhD thesis focussed on the development of computer-based alerting systems designed to improve the quality of health care.

Investigator, cognitive function and mood disorders (CoFaMS) and Cognitive and
Functional Assessment of Psychosis Staging Study (CoFAPSS) studies, with an emphasis on recruitment and assessment of patients with chronic psychosis (CoFAPPs) and lithium treated patients (CoFaMS, ConLiGen international consortium); Predictive modeling of symptom and function trajectories in mental illness (transition to first psychotic episode, treatment resistant psychosis); Pharmacogenetics and prediction of response to lithium and clozapine. Health service data linkage studies of patients with chronic psychosis; investigator in the recently established Adelaide Integrated Mental Health Biobank and Disease Marker Centre.

Investigator, cognitive function and mood disorders (CoFaMS) and Cognitive and Functional Assessment of Psychosis Staging Study (CoFAPSS) studies, with an emphasis on recruitment and assessment of patients with chronic psychosis (CoFAPPs) and lithium treated patients (CoFaMS, ConLiGen international consortium); Predictive modeling of symptom and function trajectories in mental illness (transition to first psychotic episode, treatment resistant psychosis); Pharmacogenetics and prediction of response to lithium and clozapine. Health service data linkage studies of patients with chronic psychosis; investigator in the recently established Adelaide Integrated Mental Health Biobank and Disease Marker Centre.

Appointments

Date Position Institution name
2014 Consultant psychiatrist Health SA
2013 Clinical Academic University of Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2017 Award 2017 RANZCP Early Career Psychiatrist Research Award Royal Australia & New Zealand College of Psychiatry $10000
2015 - 2015 Research Award Young Investigator Travel Award for the 15th International Congress on Schizophrenia Research University of Texas $US 2000
2014 - 2014 Nomination 2013 The National Lead Clinicians Group (LCG) Awards for Excellence in Innovative Implementation of Clinical Guidelines – Invited poster on State-wide Clozapine Monitoring Systems SA Health Travel reimbursed
2013 Teaching Award Professor Derek Frewin Citation for Clinical Teaching 2013
2012 Teaching Award Professor Derek Frewin Citation for Clinical Teaching 2012 University of Adelaide
2011 Award SA Health Improving Patient Safety Award 2011 SA Health
2002 - 2004 Scholarship Australian National Health and Medical Research Council (NHMRC) Dora Lush Biomedical Scholarship. University of Adelaide, Department of Medicine, Health Informatics Unit
1996 Scholarship APA PhD Scholarship 1996 Flinders University
1994 Award Shell Prize for 3rd Year Psychology Flinders University
1994 Recognition Flinders University Chancellor's Letter of Commendation - 1994 Flinders University
1993 Recognition Flinders University Chancellors Letter of Commendation - 1993. Flinders University
1992 Recognition Flinders University Chancellor's letter of commendation - 1992 Flinders University

Education

Date Institution name Country Title
2009 University of Adelaide Australia PhD Medicine (Health Informatics)
2004 University of Adelaide Australia MBBS
1995 - 1995 Flinders University Australia Honours Medical Science (Neuroscience)
1994 - 1994 Flinders University Australia BSc Psychology

Postgraduate Training

Date Title Institution Country
2008 - 2013 Psychiatry Registrar Royal Australian and New Zealand College of Psychiatrists Australia

Certifications

Date Title Institution name Country
2013 Fellow Royal Australian and New Zealand College of Psychiatrists

Research Interests

Cancer Biology and Clinical Oncology, Cardiac, Respiratory and Vascular Health, Nutrition and Metabolic Health, Neuroscience, Behaviour and Brain Health, Immunology and Infection, Indigenous and Disadvantaged Health

Journals

Year Citation
2018 Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Heilbronner, U. ... Cervantes, P. (2018). Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.. JAMA psychiatry, 75, 1, 65-74.
10.1001/jamapsychiatry.2017.3433
2017 Schubert, K., Air, T., Clark, S., Grzeskowiak, L., Miller, E., Dekker, G. ... Clifton, V. (2017). Trajectories of anxiety and health related quality of life during pregnancy. PLoS ONE, 12, 7, e0181149-1-e0181149-14.
10.1371/journal.pone.0181149
2017 Clark, S., Warren, N., Kim, G., Jankowiak, D., Schubert, K., Kisely, S. ... Siskind, D. (2017). Elevated clozapine levels associated with infection: A systematic review. Schizophrenia Research, -.
10.1016/j.schres.2017.03.045
2017 Schubert, K., Clark, S., Van, L., Collinson, J. & Baune, B. (2017). Depressive symptom trajectories in late adolescence and early adulthood: A systematic review. Australian and New Zealand Journal of Psychiatry, 51, 5, 477-499.
10.1177/0004867417700274
2017 Myles, N., Myles, H., Clark, S., Bird, R. & Siskind, D. (2017). Use of granulocyte-colony stimulating factor to prevent recurrent clozapine-induced neutropenia on drug rechallenge: A systematic review of the literature and clinical recommendations. Australian and New Zealand Journal of Psychiatry, 51, 10, 980-989.
10.1177/0004867417720516
2016 Clark, S., Baune, B., Schubert, K., Lavoie, S., Smesny, S., Rice, S. ... Amminger, G. (2016). Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers. Translational Psychiatry, 6, 9, 1-8.
10.1038/tp.2016.170
2016 Hou, L., Heilbronner, U., Degenhardt, F., Adli, M., Akiyama, K., Akula, N. ... Cousins, D. (2016). Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. The Lancet, 387, 10023, 1085-1093.
10.1016/S0140-6736(16)00143-4
2015 Clark, S., Schubert, K. & Baune, B. (2015). Towards indicated prevention of psychosis: using probabilistic assessments of transition risk in psychosis prodrome. Journal of Neural Transmission, 122, 1, 155-169.
10.1007/s00702-014-1325-9
2015 McGorry, P. D. (2015). Australian Early Psychosis Research Network: national collaboration, international competitive advantage. The Medical Journal of Australia, 202, 4, 170-171.
10.5694/mja14.00914
2015 Jaehne, E., Ramshaw, H., Xu, X., Saleh, E., Clark, S., Schubert, K. ... Baune, B. (2015). In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders. Pharmacology Biochemistry and Behavior, 138, 1-8.
10.1016/j.pbb.2015.09.006
2015 Tan, L., Suetani, S., Clark, S. & Wilson, D. (2015). Late onset myocarditis with clozapine use. Australian and New Zealand Journal of Psychiatry, 49, 3, 295-.
10.1177/0004867414557162
2015 Oliver Schubert, K., Clark, S. & Baune, B. (2015). The use of clinical and biological characteristics to predict outcome following first episode psychosis. Australian and New Zealand Journal of Psychiatry, 49, 1, 24-35.
10.1177/0004867414560650
2014 Clark, S., Wilton, L., Baune, B., Procter, N. & Hustig, H. (2014). A state-wide quality improvement system utilising nurse-led clinics for clozapine management. Australasian Psychiatry, 22, 3, 254-259.
10.1177/1039856214533395
2013 Fitzpatrick, A., Clark, S., Newcombe, R., Davis, A. & Baune, B. (2013). Fingolimod exacerbated affective psychosis?. Australian and New Zealand Journal of Psychiatry, 47, 4, 399-400.
10.1177/0004867412463090
2013 Manchia, M. & Baune, B. (2013). Assessment of response to lithium maintenance treatment in bipolar disorder: a consortium on lithium genetics (ConLiGen) report. PLoS One, 8, 6, 1-9.
10.1371/journal.pone.0065636

Conference Papers

Year Citation
2005 Clark, S., Pradhan, M., Adams, R., Faunt, J., Hill, A. & Guterres, A. (2005). Opportunities to reduce delay to antibiotic in community acquired pneumonia: early diagnosis modelling and simulation. National Health Informatics Conference. Melbourne, Victoria, Australia.
2003 Clark, S., Pradhan, M., Adams, R., Faunt, J. & Hill, A. (2003). Workflow assessment. National Royal Australian College of General Practitioners Computer Conference and National Health Informatics Conference. Sydney, NSW, Australia.
2000 Clark, S. R. & Pradhan, M. (2000). A Comparison Of A Paper-Based Clinical Guideline And A Decision Support System For The Management of Community Acquired Pneumonia.. Health Informatics Conference 2000 - Integrating Information for Health Care. M. Pradhan (Ed.) Adelaide.

Conference Items

Year Citation
2017 Clark, S., Amminger, P., Lin, A., Schubert, K. O., Pantelis, C., Yung, A. ... Nelson, B. (2017). PROBABILISTIC MODELING OF TRANSITION TO PSYCHOSIS USING CLINICAL AND COGNITIVE VARIABLES IN THE PERSONAL ASSESSMENT AND CRISIS EVALUATION ("PACE 400") STUDY. 16th International Congress on Schizophrenia Research (ICOSR). San Diego, CA.
2015 Schubert, K. O., Wylde, C. P., Clark, S. R. & Baune, B. T. (2015). Are Deficits in the Verbal Comprehension Index (VCI) of the Wechsler Adult Intelligence Scale (WAIS) associated with clinical and functional outcomes in Schizophrenia?. Australasian Schizophrenia Conference 2015. Melbourne.
2015 Clark, S. R., Kim, G., Jankowiak, D., Schubert, K. O. & Baune, B. T. (2015). Multiple mechanisms of clozapine toxicity related to infection. Society of Mental Health Research Conference 2015. Brisbane.
2015 Baune, B., Clark, S., Schubert, O., Rice, S., Vijayakumar, N., Schaefer, M. ... Amminger, P. (2015). Oxidative Markers for Prediction of Transition to Psychosis From the Clinical High-risk State.
10.1016/S0924-9338(15)30715-X
2015 Clark, S. R., Schubert, K. O., Rice, S., Vijayakumar, N., Schäfer, M., McGorry, P. D. ... Amminger, G. P. (2015). Can we predict psychosis in a frontline clinical setting?. Australasian Schizophrenia Conference. Melbourne.
2015 Siskind, D., Clark, S. R., Kisely, S., Rosenheck, R., Smith, G. & Whitehead, J. (2015). Managing Metabolic Adverse Drug Reactions Associated with Clozapine Treatment for People with Treatment Refractory Schizophrenia. Society for Mental Health Research. Brisbane.
2015 Clark, S. R., Schubert, K. O. & Baune, B. T. (2015). PROBABILISTIC ASSESSMENTS OF TRANSITION RISK IN THE PSYCHOSIS PRODROME. 15th International Congress on Schizophrenia Research (ICOSR). Colorado Springs, CO.
10.1093/schbul/sbv010
2015 Baune, B., Schubert, O. & Clark, S. (2015). Indicated Prevention in Clinical High Risk (Chr) for First Episode Psychosis (Fep): the Utility of an Extended Diagnostic Approach..
10.1016/S0924-9338(15)30627-1
2014 Clark, S. R., Arolt, V., Bayrakci, B. & Baune, B. T. (2014). Long-term symptoms and functional trajectories of patients with major depressive disorder post hospital discharge.. Society for Mental Health Research. Adelaide.
2014 Schubert, K. O., Higgs, L., McKay, S., Baune, B. T., Clark, S. R., Rafalowicz, E. ... Mylvaganam, S. (2014). EPIS North: a consultation-based Early Psychosis Intervention Programme supporting a general adult community mental health service.. Society for Mental Health Research (SMHR) Annual Conference. Adelaide.
2014 Clark, S. R., Baune, B. T., Schubert, K. O., Rice, S., Vijayakumar, N., Schäfer, M. R. ... Amminger, G. P. (2014). Modeling trajectories in clinical high risk of psychosis. Society for Mental Health Research. Adelaide.
2014 Clark, S. R., Wilton, L., Donohoe, P., Schubert, K. O. & Baune, B. T. (2014). General Practice based public-private clozapine monitoring.. Society for Mental Health Research. Adelaide.
2014 Suetani, S., Oh, H. & Clark, S. R. (2014). Clozapine and Constipation. Society for Mental Health Research. Adelaide.
2013 Clark, S. R. (2013). Rural Intermediate Care in South Australia: a perspective on the first 12 months.. 12th National Rural Health Conference. Adelaide.
2012 Clark, S. R. & Wilton, L. (2012). Clozapine: A Statewide Systems Approach to Improving the Quality of Care.. Royal Australian and New Zealand College of Psychiatrists’ Congress. Hobart.
2012 Clark, S. R. & Mosler, D. (2012). The Specialist Training Program in the South Australian Distance Consultation Service.. Royal Australian and New Zealand College of Psychiatry Congress. Hobart.
2011 Clark, S. R. & Wilton, L. (2011). Clozapine – Nurse Led Clinics - The dream. The coordination required to achieve consistency of practice and information flow - The reality.. 2nd Annual Mental Health Units Conference. Sydney.

Theses

Year Citation
2009 Clark, S. R.; (2009); Decision support systems for the treatment of community-acquired pneumonia;

Memberships

Date Role Membership Country
2014 - ongoing Member Society for Mental Health Research Australia
2014 - ongoing Member Fellow of the Royal Australian College of Psychiatrists Australia
2014 - ongoing Member Australian Early Psychosis Research Network Australia
2009 - ongoing Member Health Informatics Society of Australia Australia

Committee Memberships

Date Role Committee Institution Country
2016 - ongoing Member RANZCP Research Committee Royal Australian & New Zealand College of Psychiatry Australia
2015 - ongoing Member EPAS Clozapine order set working group SA Health Australia
2014 - ongoing Member Clozapine Focus Group SA Health Australia
2013 - 2014 Member Australian Society for Mental Health Research 2014 conference University of Adelaide Australia
2012 - ongoing Member EPAS Mental Health Clinical Working Party SA Health Australia
2010 - ongoing Chair Adelaide Metropolitan Clozapine Working Group SA Health Australia

Consulting/Advisories

Date Institution Department Organisation Type Country
2016 - 2016 Adelaide Primary Health Care Network Business and professional Australia
Position
Clinical Academic
Phone
83137347
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS7062.29
Org Unit
Medical Specialties

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