Scott Clark

Dr Scott Clark

Clinical Academic

Adelaide Medical School

Faculty of Health and Medical Sciences


Scott Clark is the Clinical Academic for the University of Adelaide Discipline of Psychiatry based in the Central Adelaide Local Health Network. He coordinates the Adelaide Medical School’s Psychiatry program and is a consultant psychiatrist in the Western Community Mental Health Service. Scott’s research focuses on the use of biomarkers and biotypes in the prediction of medication response and outcomes in psychosis and mood disorders. Scott was awarded the Royal Australian and New Zealand College of Psychiatrists Early Career Psychiatrist Award 2017 for his work on the use of simple Bayesian models to combine multimodal clinical and biological data to predict the first psychotic episode.
He is lead investigator for the Trajectories in Response to Aripiprazole Maintena Study (TRAMS) and the Cognition and Patterns of Gene Expression in Chronic Psychosis Associated with Cognitive and General Function as part of the Cognitive and Functional Assessment of Psychosis Staging Study (CoFAPSS), the Transcranial Magnetic Stimulation and Electrophysiology in Mood and Psychosis Study (TEMAPS) and an investigator for the Genomics of ECT International Consortium (GenECT-IC). He is a collaborator with the international Consortium for Lithium Genetics (COnLiGen).
Scott is also the Chair of the South Australian Clozapine Steering Group and has lead the introduction of a state-wide monitoring system for the use of the high risk antipsychotic clozapine. He is a senior investigator for the Detection of Clozapine Induced Myocarditis in Inpatient Mental Health Unit Prior and Post Implementation of a State-wide Monitoring Protocol, The Toxic Rise of Plasma Clozapine Levels Related to Infections or Inflammatory Reactions and its Management in Hospitalised Patients and The Characterisation of Non-Psychiatric Admissions During the First Two Years After Commencement of Clozapine studies.

Investigator, cognitive function and mood disorders (CoFaMS) and Cognitive and Functional Assessment of Psychosis Staging Study (CoFAPSS) studies, with an emphasis on recruitment and assessment of patients with chronic psychosis (CoFAPPs) and lithium treated patients (CoFaMS, ConLiGen international consortium); Predictive modeling of symptom and function trajectories in mental illness (transition to first psychotic episode, treatment resistant psychosis); Pharmacogenetics and prediction of response to lithium and clozapine. Health service data linkage studies of patients with chronic psychosis; investigator in the recently established Adelaide Integrated Mental Health Biobank and Disease Marker Centre.

 
Available Research Projects
Discipline of Psychiatry

Research Project 1 - Multimodal prediction of transition to the first psychotic episode

Project description: Only 30% of patients identified as at high risk of a psychotic episode transition to first episode psychosis. Improved accuracy of prediction is required to efficiently and safely intervene to prevent or minimise the impact of psychosis. With access to detailed national and international data sets we use novel Bayesian and machine learning techniques to combine clinical and biological variables to improve prediction accuracy.

Collaborators: A Prof Oliver Schubert (University of  Adelaide); Prof Barnaby Nelson (University of Melbourne, Orygen); Prof Stanley Zammitt (University of Bristol); Prof David Cotter (Royal College of Surgeons Ireland)

Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce); TQEH
Research project start: Semester 1 and 2
Special requirements: Nil

 

Research Project 2 - Electrophysiology and Response to Transcranial Magnetic Stimulation as biomarkers of cognition and function in mood and psychotic disorders.

Project description: There are currently no accurate biomarkers of prognosis and treatment response in major mental illness. This leads to trial and error in treatment selection and associated prolonged morbidity.  This study uses electroencephalography (EEG) and Transcranial Magnetic Stimulation (TMS) combined with EEG to measure patterns in brain wave oscillation that are associated with medication response, cognition and function in patients with mood and psychotic disorders.

Collaborators: Dr Mitchell Goldsworthy (NeuroPAD, University of Adelaide); Dr Nigel Rogash (SAHMRI, University of Adelaide); Prof Cherrie Galletly (University of Adelaide)

Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce); TQEH
Research project start: Semester 1 and 2
Special requirements: Police Clearance, vaccination required

 

Research Project 3 - Impact of relapse in schizophrenia on cognition and function: clinical and biological correlates

Project description: Relapse of psychotic illness is associated with significant personal and family trauma as well as changes in cognition and function. Improved knowledge of predictors and outcomes is required to design better interventions. This study follows a group of patients diagnosed with schizophrenia to identify the clinical and biological (Genomic & Proteomic, Inflammatory) predictors of relapse and associated changes in cognition and function. It will also define the social impact of relapse in terms of impact on carers and costs to the health system.

Collaborators: AProf Oliver Schubert, Prof Cherrie Galletly, Dr Cathy Toben, Dr Catharine Jawahar, Dr Natalie Mills (University of Adelaide). 

Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce); TQEH
Research project start: Semester 1 and 2
Special requirements: Police Clearance, vaccination required

 

Research Project 4 - Diagnosis and treatment of clozapine associated myocarditis

Project description:The atypical antipsychotic clozapine is the most efficacious antipsychotic for treatment resistant schizophrenia but has a range of severe adverse effects. In Australia rates of clozapine associated cardiac inflammation (myocarditis) are much higher than the rest of the world. Evidence suggests rates are increasing with the implementation of new screening protocols involving both inflammatory (C-reactive protein) and cardiac (troponin) markers. However, diagnosis is difficult due to other confounding aetiologies (e.g. viral myocarditis) and management following positive screens may be variable. This study reviews the diagnosis and management of potential cases of myocarditis using record linkage and case note review.

Collaborators: Jessica Dawson (Monash University); Professor John Beltrame (University of Adelaide)

Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS (Adelaide Health & Medical Sciences Building, North Tce); TQEH
Research project start: Semester 1 and 2
Special requirements: Nil

In his role as Clinical Academic for the Discipline of Psychiatry Scott coordinates the Adelaide Medical School’s year 4 Psychiatry program and the integration of the current course across year levels. At the centre of this teaching is a structured approach to assessment, formulation and management of mental illness. This model incorporates bio-psycho-socio-cultural aspects of history taking, mental state, and physical health assessment, and teaches the integration of this complex data into valid and efficient diagnostic formulation and risk assessment, leading to realistically staged, evidence-based management planning that considers complex clinical service multidisciplinary contexts. The model also provides a framework for the development of efficient case presentation and can be assessed at more advanced levels by using short case vivas to explore the student’s knowledge base, reasoning and clinical decision-making capacity. Across undergraduate teaching there is a progression from theory to practice via a balance of didactic and problem-based learning, and small group discovery experiences, allowing students to develop skills in the formulation and exploration of clinical questions and hypotheses, identifying critical gaps in knowledge and working individually and in teams toward shared goals. 

​​​​​​​Scott also lectures into the South Australian Psychiatry Branch Training Committee (SAPBTC) program and The Adelaide Pre-vocational Psychiatry Program (TAPPP) and is Convenor of the Annual SA Mental Health Service Clozapine Training Program. Scott also supervises PhD, Honours and medical student research projects as well as Psychiatry Registrar Scholarly projects. 

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Association between TMS-EEG with Symptoms, Cognition and Function in Psychiatry Disorders Doctor of Philosophy Doctorate Full Time Mr Kai Tit Tan
    2018 Co-Supervisor Personalised Psychiatry: A Machine Learning Approach Doctor of Philosophy Doctorate Full Time Mr Micah Linton Douglas Cearns
    2016 Co-Supervisor Cognitive Deficits, Functioning and Quality of Life in Individual with Schizophrenia and Bipolar Affective Disorders: Comparative Analyses with Healthy Controls Doctor of Philosophy Doctorate Full Time Dr Andrew Toyin Olagunju
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2018 - ongoing Co-Supervisor Differential Candidate Gene Analysis for Cognition and Schizophrenia University of Adelaide, Discipline of Psychiatry Faculty of Health and Medical Sciences Honours program Honours Full Time Edward Luong
    2018 - ongoing Principal Supervisor Fronto-parietal connectivity as a marker of cognition in Bipolar disorder University of Adelaide, Discipline of Psychiatry Faculty of Health and Medical Sciences Honours Program Honours Full Time Diana Bol
    2018 - ongoing Principal Supervisor Dorsolateral-Prefrontal Neuroplasticity as a Marker of Cognition in Major Depressive Disorder University of Adelaide, Discipline of Psychiatry Faculty of Health and Medical Sciences Honours Program Honours Full Time Kaitit Tan
  • Position: Clinical Academic
  • Phone: 83137347
  • Email: scott.clark@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 7
  • Room: WS7062.29
  • Org Unit: Medical Specialties

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