Nigussie Sharew

Research Interests

Epidemiology Genomics Mental Health Pharmacogenomics Neuroscience, Behaviour and Brain Health Psychiatry

Mr Nigussie Sharew

Higher Degree by Research Candidate

School of Medicine

College of Health

Nigussie is a PhD candidate in Genetic Epidemiology at the University of Adelaide, Australia. He is interested in pharmacogenomics, mental health epidemiology, clinical psychology, and precision medicine with advanced analysis like machine learning. He graduated with a Master of Science in Clinical and Psychosocial Epidemiology from the University of Groningen, the Netherlands, and a Master of Science in Adult Health Nursing from Addis Ababa University, Addis Ababa, Ethiopia. Nigussie has made significant contributions to health and medical science over many years. He has an h-index of 16 on Scopus and 21 on Google Scholar, averaging 39.4 citations per publication (SciVal). His overall Field-Weighted Impact of 8.20 (SciVal) demonstrates that his research is cited more frequently than the global average in his field.

Developing Genetic Testing Tools for Optimising Pharmacotherapy and Enabling a Precision Mental Health Care

Date Position Institution name
2022 - ongoing PhD candidate University of Adelaide

Date Type Title Institution Name Country Amount
2025 Award The John Barker Research Scholarship in Medicine The University of Adelaide Australia -
2025 Award Faculty of Health and Medical Science travel award University of Adelaide Australia -
2025 Award Pharmacogenomic Global Research Network (PGRN) conference travel award Pharmacogenomic Global Research Network (PGRN) United States -
2024 Award Borderline Personality Disorder Collaborative PhD Internship Scholarship University of Adelaide and Borderline Personality Disorder Collaborative Australia -
2022 Scholarship University of Adelaide Research Scholarship University of Adelaide Australia -
2021 Award Holland Scholarship for the University of Groningen Dutch Ministry of Education, Culture and Science Netherlands -
2020 Scholarship University of Groningen International scholarship for Postgraduate Study University of Groningen Netherlands -

Language Competency
English Can peer review

Date Institution name Country Title
2020 - 2022 University of Groningen Netherlands Master of science
2012 - 2014 Addis Ababa University Ethiopia Master of Science
2008 - 2010 Debre Berhan University Ethiopia Bachelor of Science

Date Title Institution Country
2024 - 2024 Genome-Wide Association Studies: Why, How and then What? University of Oslo Norway
Advances in Genetic Epidemiology University of Groningen Netherlands

Date Title Institution name Country
— Grant writing Oregon State University United States

Year Citation
2025 Tiruye, T. (2025). The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet, online(10512), 1-22.
DOI Scopus22 WoS42 Europe PMC20
2025 Modi, N. D. (2025). Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023. American College of Cardiology. Journal, online(22), 1-77.
DOI Scopus66 WoS57 Europe PMC31
2025 Alemu, R., Sharew, N. T., Arsano, Y. Y., Ahmed, M., Tekola-Ayele, F., Mersha, T. B., & Amare, A. T. (2025). Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.. Human Genomics, 19(1), 8-1-8-27.
DOI Scopus31 WoS20 Europe PMC17
2025 Steel, N., Bauer-Staeb, C. M. M., Ford, J. A., Abbafati, C., Abdalla, M. A., Abdelkader, A., . . . Bhaskar, S. (2025). Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021. The Lancet Public Health, 10(3), e172-e188.
DOI Scopus29 Europe PMC14
2025 GBD 2019 Acute and Chronic Care Collaborators. (2025). Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019.. Nature Communications, 16(1), 4235-1-4235-36.
DOI WoS13 Europe PMC11
2025 Sharew, N. T., Clark, S. R., Papiol, S., Heilbronner, U., Degenhardt, F., Fullerton, J. M., . . . Amare, A. T. (2025). Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder. Biological Psychiatry Global Open Science, 5(5), 100558-1-100558-13.
DOI
2025 Zhang, C., Yang, X., Wan, D., Ma, Q., Yin, P., Zhou, M., . . . Lee, M. (2025). Burden of neurological disorders in China and its provinces, 1990–2021: Findings from the global burden of disease study 2021. Med, 6(8), 100692.
DOI Scopus6 Europe PMC3
2024 Mokdad, A. H., Bisignano, C., Hsu, J. M., Bryazka, D., Cao, S., Bhattacharjee, N. V., . . . Brauer, M. (2024). Burden of disease scenarios by state in the USA, 2022–50: a forecasting analysis for the Global Burden of Disease Study 2021. The Lancet, 404(10469), 2341-2370.
DOI Scopus42 WoS39 Europe PMC32
2024 Sharew, N. T., Clark, S. R., Schubert, K. O., & Amare, A. T. (2024). Pharmacogenomic scores in psychiatry: systematic review of current evidence. Translational Psychiatry, 14(1), 322-1-322-16.
DOI Scopus12 WoS11 Europe PMC10
2024 Malekpour, M. R., Rezaei, N., Azadnajafabad, S., Khanali, J., Azangou-Khyavy, M., Moghaddam, S. S., . . . Charan, J. (2024). Global, regional, and national burden of injuries, and burden attributable to injuries risk factors, 1990 to 2019: results from the Global Burden of Disease study 2019. Public Health, 237, 212-231.
DOI Scopus14 WoS12 Europe PMC12
2023 Global Burden of Disease 2021 Health Financing Collaborator Network., Baune, B., Sharew, N., Amare, A., Olagunju, A., Opio, J. N., & Noubiap Nzeale, J. J. (2023). Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026.. The Lancet. Global health, 11(3), e385-e413.
DOI Scopus181 WoS169 Europe PMC102
2023 Tessema, G. A., Berheto, T. M., Pereira, G., Misganaw, A., Kinfu, Y., & GBD 2019 Ethiopia Child Mortality Collaborators. (2023). National and subnational burden of under-5, infant, and neonatal mortality in Ethiopia, 1990-2019: Findings from the Global Burden of Disease Study 2019. PLOS Global Public Health, 3(6), e0001471-1-e0001471-18.
DOI Scopus15 WoS13 Europe PMC14
2023 Sharew, N. T. (2023). The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990–2019: a systematic analysis of the Global Burden of Disease Study 2019. The Lancet, 402(10398), 313-335.
DOI Scopus75 WoS57 Europe PMC68
2022 Abate, M., Tadesse, N., & Mitiku, K. (2022). Level of compassionate health care service provision and its associated factors among health professionals working in public hospitals of Addis Ababa: health professionals' perspective. Heliyon, 8(3), e09160-1-e09160-7.
DOI
2022 Cheung, T., Cheng, C. P. W., Fong, T. K. H., Sharew, N. T., Anders, R. L., Xiang, Y. T., & Lam, S. C. (2022). Psychological impact on healthcare workers, general population and affected individuals of SARS and COVID-19: A systematic review and meta-analysis. Frontiers in Public Health, 10, 1004558-1-1004558-16.
DOI Scopus28 WoS27 Europe PMC26
2022 Castelpietra, G., Knudsen, A. K. S., Agardh, E. E., Armocida, B., Beghi, M., Iburg, K. M., . . . Socea, B. (2022). The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019. The Lancet Regional Health - Europe, 16, 100341-1-100341-18.
DOI Scopus256 WoS239
2022 Armocida, B., Monasta, L., Sawyer, S., Bustreo, F., Segafredo, G., Castelpietra, G., . . . Lacey, B. (2022). Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019. The Lancet Child and Adolescent Health, 6(6), 367-383.
DOI Scopus98 WoS85 Europe PMC74
2022 Habtewold, T. D., Sharew, N. T., Endalamaw, A., Mulugeta, H., Dessie, G., Asefa, N., . . . Alemu, S. M. (2022). Mapping publication outputs, collaboration networks, research hotspots, and most cited articles in systematic reviews and meta-analyses of medicine and health sciences in Ethiopia: analyses of 20 years of scientific data.
DOI
2022 Sharew, N. T. (2022). The Effect of Multimodal Non-pharmacological Interventions on Cognitive Function Improvement for People With Dementia: A Systematic Review. Frontiers in Public Health, 10, 1-7.
DOI Scopus14 WoS9 Europe PMC8
2021 Tizazu, M. A., Sharew, N. T., Mamo, T., Zeru, A. B., Asefa, E. Y., & Amare, N. S. (2021). Completing the Continuum of Maternity Care and Associated Factors in Debre Berhan Town, Amhara, Ethiopia, 2020. Journal of Multidisciplinary Healthcare, 14, 21-32.
DOI Scopus33 WoS30 Europe PMC32
2021 Mamo, H., Dagnaw, A., Sharew, N. T., Brhane, K., & Kotiso, K. S. (2021). Prevalence of short interpregnancy interval and its associated factors among pregnant women in Debre Berhan town, Ethiopia. PLoS One, 16(8), e0255613-1-e0255613-10.
DOI Scopus17 WoS15 Europe PMC15
2021 Aynalem, Y. A., Akalu, T. Y., Gebresellassie Gebregiorgis, B., Sharew, N. T., Assefa, H. K., & Shiferaw, W. S. (2021). Assessment of undergraduate student knowledge, attitude, and practices towards COVID-19 in Debre Berhan University, Ethiopia. PLoS One, 16(5), e0250444-1-e0250444-13.
DOI Scopus27 WoS25 Europe PMC33
2021 Bowers, B. J., Chu, C. H., Wu, B., Thompson, R. A., Lepore, M. J., Leung, A. Y. M., . . . McGilton, K. S. (2021). What COVID-19 Innovations Can Teach Us About Improving Quality of Life in Long-Term Care. Journal of the American Medical Directors Association (JAMDA), 22(5), 929-932.
DOI Scopus12 WoS13 Europe PMC12
2021 Habtewold, T. D., Endalamaw, A., Mohammed, S. H., Mulugeta, H., Dessie, G., Kassa, G. M., . . . Alemu, S. M. (2021). Sociodemographic Factors Predicting Exclusive Breastfeeding in Ethiopia: Evidence from a Meta-analysis of Studies Conducted in the Past 10 Years. Maternal and Child Health Journal, 25(1), 72-94.
DOI Scopus8 WoS7 Europe PMC10
2021 Geset Haile, D., Taddess, N., Mekuria, A. D., Abebe, A. M., & Mezemir, Y. (2021). Prevalence of Hypertension and Associated Factors Among Adults in Debre Berhan Town, North Shoa Zone, Ethiopia, 2020. Vascular Health and Risk Management, 17, 203-210.
DOI Scopus4 WoS6 Europe PMC7
2021 Yimer, N. B., Mohammed, M. A., Solomon, K., Tadese, M., Grutzmacher, S., Meikena, H. K., . . . Habtewold, T. D. (2021). Cervical cancer screening uptake in Sub-Saharan Africa: a systematic review and meta-analysis. Public Health, 195, 105-111.
DOI Scopus120 WoS117 Europe PMC118
2021 Sharew, N. T., LAM, S. C., Habtewold, T. D., & Leung, A. Y. M. (2021). Effect of multimodal non‐pharmacologic interventions on cognitive function for people with dementia: Systematic review. Alzheimer's and Dementia, 17(S8), e057657.
DOI
2020 Habtewold, T. D., Sharew, N. T., & Alemu, S. M. (2020). Evidence on the effect of gender of new-born, antenatal care and postnatal care on breastfeeding practices in Ethiopia: a meta-analysis and meta-regression analysis of observational studies (vol 9, e023956, 2019). BMJ OPEN, 10(1), 2 pages.
DOI
2019 Habtewold, T. D., Sharew, N. T., & Alemu, S. M. (2019). Evidence on the effect of gender of newborn, antenatal care and postnatal care on breastfeeding practices in Ethiopia: a meta-analysis and meta-regression analysis of observational studies. BMJ Open, 9(5), e023956-1-e023956-19.
DOI Scopus24 WoS20 Europe PMC16
2019 Habtewold, T. D., Mohammed, S. H., Endalamaw, A., Akibu, M., Sharew, N. T., Alemu, Y. M., . . . Tegegne, B. S. (2019). Breast and complementary feeding in Ethiopia: new national evidence from systematic review and meta-analyses of studies in the past 10 years. European Journal of Nutrition, 58(7), 2565-2595.
DOI Scopus25 WoS21 Europe PMC29
2019 Mohammed, M. A., & Sharew, N. T. (2019). Adherence to dietary recommendation and associated factors among diabetic patients in ethiopian teaching hospitals. Pan African Medical Journal, 33, 11 pages.
DOI Scopus40 WoS31 Europe PMC33
2018 Habtewold, T. D., Sharew, N. T., & Alemu, S. M. (2018). Effect of gender of new-born, antenatal care and postnatal care on breastfeeding practices in Ethiopia: Evidence from systematic review and meta-analysis of national studies.
DOI Europe PMC1
2018 Sharew, N. T., Bizuneh, H. T., Assefa, H. K., & Habtewold, T. D. (2018). Investigating admitted patients' satisfaction with nursing care at Debre Berhan Referral Hospital in Ethiopia: a cross-sectional study. BMJ Open, 8(5), e021107-1-e021107-8.
DOI Scopus32 WoS29 Europe PMC26
2018 Nand, D., Naghavi, M., Marczak, L. B., Kutz, M., Shackelford, K. A., Arora, M., . . . Mendoza, W. (2018). Global mortality from firearms, 1990-2016. JAMA Journal of the American Medical Association, 320(8), 792-814.
DOI Scopus258 WoS199 Europe PMC157
2017 Sharew, N. T., Mulu, G. B., Habtewold, T. D., & Gizachew, K. D. (2017). Occupational exposure to sharps injury among healthcare providers in Ethiopia regional hospitals. Annals of Occupational and Environmental Medicine, 29(1), 7 pages.
DOI Scopus20 WoS19 Europe PMC18
2017 Habtewold, T. D., Islam, M. A., Sharew, N. T., Mohammed, S. H., Birhanu, M. M., & Tegegne, B. S. (2017). SystEmatic review and meta-aNAlysis of infanT and young child feeding Practices (ENAT-P) in Ethiopia: Protocol. BMJ Open, 7(8), 6 pages.
DOI Scopus11 WoS11 Europe PMC12
2015 Dejenie Habtewold, T., Radie, Y. T., & Sharew, N. T. (2015). Prevalence of depression among type 2 diabetic outpatients in black lion general specialized hospital, addis ababa, ethiopia. Depression Research and Treatment, 2015, 184902.
DOI Scopus27 Europe PMC21
- Eshete, A., Mohammed, S., Shine, S., Eshetie, Y., Assefa, Y., & Tadesse, N. (2023). Effect of physical activity promotion program on adherence to physical exercise among patients with type II diabetes in North Shoa Zone Amhara region: a quasi-experimental study. BMC Public Health, 23(1).
DOI

Year Citation
2025 Sharew, N., Clark, S., Hartman, S., Schubert, O., & Amare, A. (2025). MULTI-TRAIT POLYGENIC SCORES IN PREDICTING LITHIUM RESPONSE IN PATIENTS WITH BIPOLAR DISORDER: A MACHINE LEARNING ANALYSIS. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 118 (pp. 1 page). WILEY.

Year Citation
2026 Sharew, N. T., Clark, S. R., Hartmann, S., Papiol, S., International Consortium on Lithium Genetics Collaborators., Schulze, T. G., . . . Amare, A. T. (2026). Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder..
DOI
2025 Sharew, N. T., Clark, S. R., Papiol, S., Heilbronner, U., Degenhardt, F., Fullerton, J. M., . . . Amare, A. T. (2025). Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder..
DOI
2024 Sharew, N., Clark, S., Schubert, O., & Amare, A. (2024). Pharmacogenomic scores in psychiatry: Systematic review of existing evidence.
DOI
2023 Habtewold, T. D., Sharew, N. T., Endalamaw, A., Mulugeta, H., Dessie, G., Kassa, G. M., . . . Alemu, S. M. (2023). Methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality.
DOI
2022 Cheung, T., Cheng, C. P. W., Fong, T. K. H., Sharew, N. T., Anders, R., Xiang, Y. -T., . . . Working-Group, S. -N. (2022). Immediate psychological impact on healthcare workers, general population and affected individuals of SARS and COVID-19: A systematic review and meta-analysis.
DOI
2022 Habtewold, T. D., Sharew, N. T., Endalamaw, A., Mulugeta, H., Dessie, G., Kassa, G. M., . . . Alemu, S. M. (2022). Current status of methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality.
DOI
2022 Cheung, T., Cheng, C. P. W., Fong, T. K. H., Sharew, N. T., Anders, R. L., Xiang, Y. T., & Lam, S. C. (2022). Immediate psychological impact on healthcare workers, general population and affected individuals of SARS and COVID-19: A systematic review and meta-analysis (Preprint).
DOI
2021 Wubetu, Y. A., Sharew, N. T., & Mohammed, O. Y. (2021). Respectful Delivery Care and Associated Factors in Public Health Facilities in Debre Berhan Town, Ethiopia.
DOI
2021 Mamo, H., Dagnaw, A., Tadesse, N., Berhane, K., & Shiferaw, K. (2021). Prevalence of short interpregnancy interval and its associated factors among pregnant women in Debre Berhan town, Ethiopia.
DOI
2021 Yimer, N. B., Mohammed, M. A., Solomon, K., Tadese, M., Grutzmacher, S., Meikena, H. K., . . . Habtewold, T. D. (2021). Cervical cancer screening uptake in Sub-Saharan Africa: a systematic review and meta-analysis.
DOI
2020 Aynalem, Y. A., Akalu, T. Y., Gebresellassie, B., Sharew, N. T., & Shiferaw, W. S. (2020). Assessment of undergraduate student knowledge, practices, and attitude towards COVID-19 in Debre Berhan University, Ethiopia.
DOI Europe PMC2
2019 Habtewold, T. D., Endalamaw, A., Mohammed, S. H., Mulugeta, H., Dessie, G., Kassa, G. M., . . . Alemu, S. M. (2019). Multidimensional factors predicting exclusive breastfeeding in Ethiopia: evidence from a meta-analysis of studies in the past 10 years.
DOI

2022-2026 University of Adelaide Research Scholarship Recipient [Adelaide, Australia] 

2025 Winner of the John Barker Supplementary Research Scholarship in Medicine [Adelaide, Australia]

2025 Recipient of the Faculty of Health and Medical Science travel award [Adelaide, Australia]

2025 Travel Award Winner of the 2025 Pharmacogenomic Global Research Network (PGRN) Conference [Montana, USA]

2024 Borderline Personality Disorder Collaborative PhD Internship by the University of Adelaide [Adelaide, Australia)

2020-2022 University of Groningen International Scholarship for Postgraduate Study [Groningen, the Netherlands]

2021-2022 Holland Scholarship for the University of Groningen from the Dutch Ministry of Education, Culture and Science [Groningen, the Netherlands]

 

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