Rui Chen
School of Chemical Engineering
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Rui Chen (Richard) is a postdoctoral research fellow in the School of Chemical Engineering and Advanced Materials at the University of Adelaide. His research work is primarily funded by a CRC-P grant project "mRNA manufacturing and formulation service for late-stage clinical trials", where he contributes to assessment of mRNA lipid nanoparticle (LNP) quality, evaluation of nano-formulation stability, optimization of mRNA LNP bioprocessing, and development of ready-to-inject liquid aqueous preparations that can be stored at 5 +/- 3 degrees Celsius.
With a doctoral degree in chemistry and a postdoctoral study in cancer immunotherapy, Dr. Rui Chen has expertise in designing nanomaterial for cancer-targeted drug/gene delivery, validating drug/gene delivery systems in vitro, and evaluating cancer therapeutics for immunotherapy in vivo. His research focuses on development of applicable therapeutic strategies and clinical translation of nano-biomedicine for gene delivery and cancer immunotherapy.
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Appointments
Date Position Institution name 2023 - ongoing Postdoctoral research fellow The University of Adelaide 2019 - 2022 Postdocotral research fellow University of Queensland 2017 - 2018 Research associate City University of Hong Kong -
Education
Date Institution name Country Title 2014 - 2017 City University of Hong Kong Hong Kong PhD -
Research Interests
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Journals
Year Citation 2019 Zhang, J., Nie, W., Chen, R., Chelora, J., Wan, Y., Cui, X., . . . Lee, C. -S. (2019). Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy.. Nano letters, 19(2), 658-665.
Scopus46 WoS35 Europe PMC122019 Chen, R., Chen, W. -C., Yan, L., Tian, S., Liu, B., Chen, X., . . . Zhang, W. (2019). Harnessing combinational phototherapy via post-synthetic PpIX conjugation on nanoscale metal-organic frameworks.. Journal of materials chemistry. B, 7(31), 4763-4770.
Scopus13 WoS10 Europe PMC32019 Wan, Y., Lu, G., Zhang, J., Wang, Z., Li, X., Chen, R., . . . Lee, C. -S. (2019). A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy. ADVANCED FUNCTIONAL MATERIALS, 29(39), 10 pages.
Scopus99 WoS892019 Cui, X., Zhang, J., Wan, Y., Fang, F., Chen, R., Shen, D., . . . Lee, C. S. (2019). Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells. ACS Applied Bio Materials, 2(9), 3854-3860.
Scopus45 WoS37 Europe PMC52018 Zhang, J., Chen, J., Ren, J., Guo, W., Li, X., Chen, R., . . . Lee, C. -S. (2018). Biocompatible semiconducting polymer nanoparticles as robust photoacoustic and photothermal agents revealing the effects of chemical structure on high photothermal conversion efficiency.. Biomaterials, 181, 92-102.
Scopus71 WoS62 Europe PMC92017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Chemical Sensing: Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection (Part. Part. Syst. Charact. 6/2017). Particle and Particle Systems Characterization, 34(6).
Scopus162017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 34(6), 6 pages.
Scopus26 WoS322017 Chelora, J., Zhang, J., Chen, R., Chandran, H. T., & Lee, C. S. (2017). Highly stable red-emitting polymer dots for cellular imaging. Nanotechnology, 28(28), 7 pages.
Scopus7 WoS7 Europe PMC12017 Chen, R., Zhang, J., Chelora, J., Xiong, Y., Kershaw, S. V., Li, K. F., . . . Lee, C. S. (2017). Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Applied Materials and Interfaces, 9(7), 5699-5708.
Scopus145 WoS120 Europe PMC272017 Zhang, J., Zhang, J., Li, W., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. -S. (2017). Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy <i>in Vitro</i> and <i>in Vivo</i>.. Theranostics, 7(12), 3007-3020.
Scopus79 WoS66 Europe PMC282017 Zhang, J., Yang, C., Zhang, R., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. S. (2017). Biocompatible D–A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy. Advanced Functional Materials, 27(13), 10 pages.
Scopus201 WoS181 Europe PMC512016 Wang, Z., Chen, B., Susha, A. S., Wang, W., Reckmeier, C. J., Chen, R., . . . Rogach, A. L. (2016). All-Copper Nanocluster Based Down-Conversion White Light-Emitting Devices. Advanced Science, 3(11), 7 pages.
Scopus89 WoS100 Europe PMC162016 Zhang, J., Chen, W., Kalytchuk, S., Li, K. F., Chen, R., Adachi, C., . . . Lee, C. S. (2016). Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging. ACS Applied Materials and Interfaces, 8(18), 11355-11365.
Scopus56 WoS50 Europe PMC102016 Zhang, J., Chen, W., Chen, R., Liu, X. K., Xiong, Y., Kershaw, S. V., . . . Lee, C. S. (2016). Organic nanostructures of thermally activated delayed fluorescent emitters with enhanced intersystem crossing as novel metal-free photosensitizers. Chemical Communications, 52(79), 11744-11747.
Scopus67 WoS59 Europe PMC72015 Chen, R., Zhang, J., Wang, Y., Chen, X., Zapien, J. A., & Lee, C. S. (2015). Graphitic carbon nitride nanosheet@metal-organic framework core-shell nanoparticles for photo-chemo combination therapy. Nanoscale, 7(41), 17299-17305.
Scopus167 WoS151 Europe PMC352015 Zhang, J., Chen, R., Zhu, Z., Adachi, C., Zhang, X., & Lee, C. S. (2015). Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging. ACS Applied Materials and Interfaces, 7(47), 26266-26274.
Scopus127 WoS40 Europe PMC312014 Huang, H., Chen, R., Ma, J., Yan, L., Zhao, Y., Wang, Y., . . . Chen, X. (2014). Graphitic carbon nitride solid nanofilms for selective and recyclable sensing of Cu<sup>2+</sup> and Ag<sup>+</sup> in water and serum. Chemical Communications, 50(97), 15415-15418.
Scopus95 WoS91 Europe PMC17
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Development of mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Jitong Lyu 2023 Co-Supervisor Development of platform technologies for mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Zhenwei Lan 2023 Co-Supervisor Comparative Analysis of mRNA Loading, Cargo Release, and Cellular Uptake Between Virus-Like Particles and Lipid Nanoparticles Doctor of Philosophy Doctorate Full Time Mr Xiaoyan Wang
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