Rui Chen

Rui Chen

School of Chemical Engineering

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr Rui Chen (Richard) is a postdoctoral research fellow in the School of Chemical Engineering and Advanced Materials at the University of Adelaide. His research work is primarily funded by a CRC-P grant project "mRNA manufacturing and formulation service for late-stage clinical trials", where he contributes to assessment of mRNA lipid nanoparticle (LNP) quality, evaluation of nano-formulation stability, optimization of mRNA LNP bioprocessing, and development of ready-to-inject liquid aqueous preparations that can be stored at 5 +/- 3 degrees Celsius.
With a doctoral degree in chemistry and a postdoctoral study in cancer immunotherapy, Dr. Rui Chen has expertise in designing nanomaterial for cancer-targeted drug/gene delivery, validating drug/gene delivery systems in vitro, and evaluating cancer therapeutics for immunotherapy in vivo. His research focuses on development of applicable therapeutic strategies and clinical translation of nano-biomedicine for gene delivery and cancer immunotherapy.

  • Appointments
    Date Position Institution name
    2023 - ongoing Postdoctoral research fellow The University of Adelaide
    2019 - 2022 Postdocotral research fellow University of Queensland
    2017 - 2018 Research associate City University of Hong Kong

  • Education
    Date Institution name Country Title
    2014 - 2017 City University of Hong Kong Hong Kong PhD

  • Research Interests
    Cancer Therapy Immunology Nanomedicine

  • Journals
    Year Citation
    2019 Zhang, J., Nie, W., Chen, R., Chelora, J., Wan, Y., Cui, X., . . . Lee, C. -S. (2019). Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy.. Nano letters, 19(2), 658-665.
    DOI Scopus46 WoS35 Europe PMC12
    2019 Chen, R., Chen, W. -C., Yan, L., Tian, S., Liu, B., Chen, X., . . . Zhang, W. (2019). Harnessing combinational phototherapy via post-synthetic PpIX conjugation on nanoscale metal-organic frameworks.. Journal of materials chemistry. B, 7(31), 4763-4770.
    DOI Scopus13 WoS10 Europe PMC3
    2019 Wan, Y., Lu, G., Zhang, J., Wang, Z., Li, X., Chen, R., . . . Lee, C. -S. (2019). A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy. ADVANCED FUNCTIONAL MATERIALS, 29(39), 10 pages.
    DOI Scopus99 WoS89
    2019 Cui, X., Zhang, J., Wan, Y., Fang, F., Chen, R., Shen, D., . . . Lee, C. S. (2019). Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy against Hypoxic Cancer Cells. ACS Applied Bio Materials, 2(9), 3854-3860.
    DOI Scopus45 WoS37 Europe PMC5
    2018 Zhang, J., Chen, J., Ren, J., Guo, W., Li, X., Chen, R., . . . Lee, C. -S. (2018). Biocompatible semiconducting polymer nanoparticles as robust photoacoustic and photothermal agents revealing the effects of chemical structure on high photothermal conversion efficiency.. Biomaterials, 181, 92-102.
    DOI Scopus71 WoS62 Europe PMC9
    2017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Chemical Sensing: Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection (Part. Part. Syst. Charact. 6/2017). Particle and Particle Systems Characterization, 34(6).
    DOI Scopus16
    2017 Wang, Z., Chen, R., Xiong, Y., Cepe, K., Schneider, J., Zboril, R., . . . Rogach, A. L. (2017). Incorporating Copper Nanoclusters into Metal-Organic Frameworks: Confinement-Assisted Emission Enhancement and Application for Trinitrotoluene Detection. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 34(6), 6 pages.
    DOI Scopus26 WoS32
    2017 Chelora, J., Zhang, J., Chen, R., Chandran, H. T., & Lee, C. S. (2017). Highly stable red-emitting polymer dots for cellular imaging. Nanotechnology, 28(28), 7 pages.
    DOI Scopus7 WoS7 Europe PMC1
    2017 Chen, R., Zhang, J., Chelora, J., Xiong, Y., Kershaw, S. V., Li, K. F., . . . Lee, C. S. (2017). Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Applied Materials and Interfaces, 9(7), 5699-5708.
    DOI Scopus145 WoS120 Europe PMC27
    2017 Zhang, J., Zhang, J., Li, W., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. -S. (2017). Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy <i>in Vitro</i> and <i>in Vivo</i>.. Theranostics, 7(12), 3007-3020.
    DOI Scopus79 WoS66 Europe PMC28
    2017 Zhang, J., Yang, C., Zhang, R., Chen, R., Zhang, Z., Zhang, W., . . . Lee, C. S. (2017). Biocompatible D–A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy. Advanced Functional Materials, 27(13), 10 pages.
    DOI Scopus201 WoS181 Europe PMC51
    2016 Wang, Z., Chen, B., Susha, A. S., Wang, W., Reckmeier, C. J., Chen, R., . . . Rogach, A. L. (2016). All-Copper Nanocluster Based Down-Conversion White Light-Emitting Devices. Advanced Science, 3(11), 7 pages.
    DOI Scopus89 WoS100 Europe PMC16
    2016 Zhang, J., Chen, W., Kalytchuk, S., Li, K. F., Chen, R., Adachi, C., . . . Lee, C. S. (2016). Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging. ACS Applied Materials and Interfaces, 8(18), 11355-11365.
    DOI Scopus56 WoS50 Europe PMC10
    2016 Zhang, J., Chen, W., Chen, R., Liu, X. K., Xiong, Y., Kershaw, S. V., . . . Lee, C. S. (2016). Organic nanostructures of thermally activated delayed fluorescent emitters with enhanced intersystem crossing as novel metal-free photosensitizers. Chemical Communications, 52(79), 11744-11747.
    DOI Scopus67 WoS59 Europe PMC7
    2015 Chen, R., Zhang, J., Wang, Y., Chen, X., Zapien, J. A., & Lee, C. S. (2015). Graphitic carbon nitride nanosheet@metal-organic framework core-shell nanoparticles for photo-chemo combination therapy. Nanoscale, 7(41), 17299-17305.
    DOI Scopus167 WoS151 Europe PMC35
    2015 Zhang, J., Chen, R., Zhu, Z., Adachi, C., Zhang, X., & Lee, C. S. (2015). Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging. ACS Applied Materials and Interfaces, 7(47), 26266-26274.
    DOI Scopus127 WoS40 Europe PMC31
    2014 Huang, H., Chen, R., Ma, J., Yan, L., Zhao, Y., Wang, Y., . . . Chen, X. (2014). Graphitic carbon nitride solid nanofilms for selective and recyclable sensing of Cu<sup>2+</sup> and Ag<sup>+</sup> in water and serum. Chemical Communications, 50(97), 15415-15418.
    DOI Scopus95 WoS91 Europe PMC17

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2023 Co-Supervisor Development of mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Jitong Lyu
    2023 Co-Supervisor Development of platform technologies for mRNA therapeutics Doctor of Philosophy Doctorate Full Time Mr Zhenwei Lan
    2023 Co-Supervisor Comparative Analysis of mRNA Loading, Cargo Release, and Cellular Uptake Between Virus-Like Particles and Lipid Nanoparticles Doctor of Philosophy Doctorate Full Time Mr Xiaoyan Wang
Connect With Me
External Profiles