Dr Patrick Hughes
School of Medicine
College of Health
Dr Patrick HughesDr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.
Gastrointestinal Neuroimmune Interactions Research Group
The Gastrointestinal Neuroimmune Interactions group investigates how altered communication between the nervous and immune systems lead to symptoms in gastrointestinal diseases, primary Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). This will lead to novel targets for new treatments and diagnostics for these diseases.
https://www.researchgate.net/profile/Patrick_Hughes6
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=%22Hughes+PA%22%5Bau%5D&dispmax=50
Current projects:
Research in the Gastrointestinal Neuroimmune Interactions group combines cutting edge techniques in molecular biology, tissue culture, flow cytometry, functional assays and imaging in both pre-clinical animal models and human tissue.
1: Is naive and relapsing inflammation of the colon the same?
Inflammatory Bowel Disease is characterised by chronic inflammation that comes and goes over time. However, little is understood regarding how colonic immune and nerve responses differ between the initial disease and subsequent relapses. This project builds on our previous publications demonstrating that immune, epithelial barrier, microbiota profile and colonic nerve responses differ depending on the stage of disease. https://www.ncbi.nlm.nih.gov/pubmed/30794280 , https://www.ncbi.nlm.nih.gov/pubmed/27864046.
2: How do microbial products maintain immune and physiological homeostasis in the colon?
There is increasing evidence that the microbiota is altered in many diseases, but little is understood regarding the effects of microbial products on the colonic immune and nervous systems. This project builds on our recent demonstration that faecal microbiota transplant induces remission in ulcerative colitis (https://www.ncbi.nlm.nih.gov/pubmed/30644982) and combines investigations of human samples with animal models of colitis to understand how changes in microbiota composition affect the physiology of the gastrointestinal tract.
3: Novel techniques for imaging colonic inflammation.
We are developing in-vivo techniques for imaging colonic inflammation in collaboration with MITRU at SAHMRI. We recently demonstrated that radiolabelled antibodies against immune markers detect colonic inflammation (https://www.ncbi.nlm.nih.gov/pubmed/30413657).
4: The role of stress in colonic disease.
Stress is a common feature in inflammatory bowel disease and irritable bowel syndrome. While stress is known to alter gastrointestinal physiology and immune function, little is understood regarding how this relates to the mechanisms underlying symptoms in these diseases.
| Date | Position | Institution name |
|---|---|---|
| 2014 - ongoing | Senior Lecturer | University of Adelaide |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2004 - 2008 | University of Adelaide | Adelaide | PhD |
| 1999 - 1999 | University of Adelaide | Australia | B.Sc. (Hons). |
| Year | Citation |
|---|---|
| 2020 | Dmochowska, N., Tieu, W., Keller, M. D., Hollis, C., Campaniello, M., Mavrangelos, C., . . . Hughes, P. (2020). Detection of colitis induced intestinal and kidney fibrosis using α-pro-MMP9 immuno-PET. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 32 (pp. 1 page). WILEY. |
| 2018 | Hughes, P., Wardill, H., Choo, J., Dmochowska, N., Campaniello, M., Mavrangelos, C., . . . Rogers, G. (2018). Acute colitis chronically alters epithelial barrier and adaptive and innate immune responses to subsequent colitis re-activation independently of shifts in microbiota composition. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. |
| 2016 | Bashashati, M., Moossavi, S., Rezaei, N., Moraveji, S., Cremon, C., Hughes, P. A., . . . Barbara, G. (2016). Colonic Immune Cells in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. In GASTROENTEROLOGY Vol. 150 (pp. S951-S952). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI |
| 2014 | Hughes, P. A., Mikocka-Walus, A. A., Moretta, M., Pilichiewicz, A. N., Bampton, P. A., & Andrews, J. M. (2014). Cognitive Behavioural Therapy (CBT) Influences Innate and Adaptive Inflammatory Responsiveness in IBD Patients With Clinical Remission Sustained Over 6 Months: A Randomised Control Trial. In GASTROENTEROLOGY Vol. 146 (pp. S593). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS1 |
| 2013 | Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. |
| 2012 | Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. |
| 2012 | Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS5 |
| 2011 | Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. In GASTROENTEROLOGY Vol. 140 (pp. S538). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS18 |
| 2011 | Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. |
| 2011 | Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Hughes, P. A., Blackshaw, L. A., . . . Holtmann, G. (2011). Small Bowel Homing T Cells Are Associated With Symptoms and Delayed Gastric Emptying in Functional Dyspepsia. In GASTROENTEROLOGY Vol. 140 (pp. S139). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. |
| 2011 | Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. |
| 2010 | Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC. DOI |
| 2010 | Mikocka-Walus, A. A., Bond, M., Holloway, R. H., Persson, J., Pilichiewicz, A. N., Hughes, P. A., . . . Andrews, J. M. (2010). Does Cognitive-Behavioural Therapy (CBT) Improve Outcomes in Inflammatory Bowel Disease (IBD)? Initial Feasibility Report on a Pilot Randomised Controlled Trial. In GASTROENTEROLOGY Vol. 138 (pp. S521-S522). W B SAUNDERS CO-ELSEVIER INC. WoS6 |
| 2009 | Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V.. DOI |
| 2009 | Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden. |
| 2009 | Hughes, P. A., Brierley, S. M., Persson, J., Liebregts, T., Adam, B., Holtmann, G., & Blackshaw, L. A. (2009). Immune Cell Supernatants from IBS Patient Subtypes Differentially Affect Visceral Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 136 (pp. A75). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. |
| 2008 | Hughes, P. A., Brierley, S. M., Liebregts, T., Adam, B., Holtmann, G. J., & Blackshaw, L. A. (2008). Sensitization of visceral afferents by immune cell supernatants from IBS patients. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. |
| 2008 | Hughes, P. A., Brierley, S. M., & Blackshaw, L. A. (2008). Delayed post-inflammatory hypersensitivity in sub-populations of colonic afferents. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. |
| 2008 | Brierley, S. M., Hughes, P. A., Page, A. J., O'Donnell, T. A., Martin, C. M., Kwan, K. Y., . . . Blackshaw, L. A. (2008). Novel and specific roles for the ion channel TRPA1 in visceral sensory transduction. In GASTROENTEROLOGY Vol. 134 (pp. A8). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS4 |
| 2007 | Brierley, S. M., Hughes, P. A., Page, A. J., & Blackshaw, L. A. (2007). Mechanical hypersensitivity of mouse colonic afferents after activation of the ion channel Trpa1. In GASTROENTEROLOGY Vol. 132 (pp. A600). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. |
| 2007 | Brierley, S. M., Hughes, P. A., Page, A. J., Adam, B., Liebregts, T., Holtmann, G., . . . Blackshaw, L. (2007). Mice lacking the TRPV4 ion channel display major deficits in spinal colonic but not vagal gastroesophageal mechanosensory function. In GASTROENTEROLOGY Vol. 132 (pp. A156). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. WoS2 |
| Year | Citation |
|---|---|
| 2018 | Dmochowska, N., Campaniello, M., Mavrangelos, C., Wardill, H., Takhar, P., Keller, M., . . . Hughes, P. (2018). "In vivo" PET imaging of innate immune responses in murine DSS colitis. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY. |
| 2018 | Hughes, P., Wardill, H., Dmochowska, N., Mavrangelos, C., Campaniello, M., Bowen, J., . . . Andrews, J. (2018). Proteolytic activation of IL-1 beta impairs epithelial barrier integrity in the ulcerative colitis lumen. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Brisbane, Qld: Wiley. |
| 2017 | Costello, S., Waters, O., Bryant, R., Katsikeros, R., Makanyanga, J., Schoeman, M., . . . Andrews, J. (2017). Short duration, low intensity pooled faecal microbiota transplantation induces remission in patients with mild-moderately active ulcerative colitis: a randomised controlled trial. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. WoS31 |
| 2017 | Costello, S., Mashei, C., Bryant, R., Katsikeros, R., Waters, O., Makanyanga, J., . . . Andrews, J. (2017). Comparison of dietary nutrient and food additive intake between patients with moderately active ulcerative colitis, healthy stool donors and the general Australian population. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. |
| 2017 | Wardill, H., Bowen, J., Dmochowska, N., Campaniello, M., Mavrangelos, C., Holloway, R., . . . Hughes, P. (2017). Faecal supernatants from diarrhoea predominant Irritable Bowel Syndrome (IBS) patients disrupt colonic epithelial barrier function and directly activate colo-rectal afferent nerves. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley. DOI |
| 2017 | Wardill, H. R., Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Bowen, J. M., Andrews, J. M., . . . Hughes, P. A. (2017). Fecal supernatants from active ulcerative colitis patients impair colonic epithelial barrier integrity and activate pelvic mucosal extrinsic afferent nerves. Poster session presented at the meeting of FASEB Journal. Chicago, IL: Federation of American Societies for Experimental Biology. |
| 2017 | Mikocka-Walus, A., Hughes, P., Bampton, P., Gordon, A., Campaniello, M., Mavrangelos, C., . . . Andrews, J. (2017). FLUOXETINE FOR MAINTENANCE OF REMISSION AND TO IMPROVE QUALITY OF LIFE IN PATIENTS WITH CROHN'S DISEASE: A PILOT RANDOMIZED PLACEBO-CONTROLLED TRIAL. Poster session presented at the meeting of AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. SAGE PUBLICATIONS LTD. |
| 2017 | Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2017). COGNITIVE BEHAVIOURAL THERAPY FOR INFLAMMATORY BOWEL DISEASE: 24-MONTH DATA FROM A RANDOMIZED CONTROLLED TRIAL. Poster session presented at the meeting of AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. SAGE PUBLICATIONS LTD. WoS1 |
| 2017 | Mavrangelos, C., Campaniello, M., Andrews, J., Bampton, P., & Hughes, P. (2017). Longitudinal analysis of IBS patients reveals that acquired immune responses are inhibited in symptom flare vs symptom free. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley. DOI |
| 2017 | Costello, S. P., Waters, O., Bryant, R. V., Katsikeros, R., Makanyanga, J., Schoeman, M., . . . Andrews, J. M. (2017). SHORT DURATION, LOW INTENSITY, POOLED FECAL MICROBIOTA TRANSPLANTATION INDUCES REMISSION IN PATIENTS WITH MILD-MODERATELY ACTIVE ULCERATIVE COLITIS: A RANDOMISED CONTROLLED TRIAL. Poster session presented at the meeting of GASTROENTEROLOGY. Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. DOI WoS37 |
| 2016 | Adams, J. H., Baker, L., Cepeda, J., Hughes, P., Silber, A., & Ahmed, R. (2016). Management of Maternal Cardiac Arrest in the Third Trimester of Pregnancy: A Simulation-Based Pilot Study. Poster session presented at the meeting of OBSTETRICS AND GYNECOLOGY. Washington, DC: LIPPINCOTT WILLIAMS & WILKINS. DOI |
| 2016 | Campaniello, M., Mavrangelos, C., Dimasi, D., Hofma, B., Eade, S., Smid, S., . . . Hughes, P. A. (2016). Innate cell infiltration during acute TNBS colitis alters enteric nerve activity. Poster session presented at the meeting of Gastroenterology. San Diego, CA: Elsevier Inc.. DOI |
| 2016 | Campaniello, M., Mavrangelos, C., Bampton, P. A., Andrews, J. M., & Hughes, P. A. (2016). Expression of Gut Homing Markers on TReg Differs Between IBS and Remissive IBD. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI |
| 2016 | Mikocka-Walus, A., Andrews, J., Bampton, P., Hetzel, D., Hughes, P., & Esterman, A. (2016). Cognitive-behavioural therapy has no effect on disease activity but it improves quality of life in sub-groups of patients with inflammatory bowel disease short-term: a randomised controlled trial with a 24-month follow-up. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. WoS1 |
| 2015 | Hughes, P., & Campaniello, M. (2015). Distinct differences in the immune profile of acute, remissive and reactivated murine TNBS colitis. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. Istanbul, TURKEY: WILEY. |
| 2015 | Malsch, P., Andratsch, M., Vogl, C., Link, A. S., Alzheimer, C., Brierley, S. M., . . . Kress, M. (2015). Functional interaction of signal transducer gp130 and TRPA1 for mechanonociception and neuropathic pain. Poster session presented at the meeting of ACTA PHYSIOLOGICA. WILEY-BLACKWELL. |
| 2014 | Mikocka-Walus, A., Hughes, P., Moretta, M., Pilichiewicz, A., Long, H., Hetzel, D., . . . Andrews, J. (2014). Cognitive-behavioural therapy (CBT) improves inflammatory responsiveness but not mental health short term in IBD patients: A pilot randomised controlled trial. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. DOI WoS2 |
| 2013 | Hughes, P. A., Moretta, M., Bird, D., Grasby, D., Lim, A., Brierley, S. M., . . . Krumbiegel, D. (2013). Beta-endorphin secretion by monocyte/macrophages is deficient in irritable bowel syndrome: a contributor to visceral hypersensitivity?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL. |
| 2013 | Hughes, P., Moretta, M., Lim, A., Grasby, D., Bird, D., Bampton, P., . . . Krumbiegel, D. (2013). Lack of macrophage/monocyte derived β-endorphin contributes toward sensations of pain/discomfort in Irritable Bowel Syndrome. Poster session presented at the meeting of JOURNAL OF IMMUNOLOGY. Honolulu, HI: AMER ASSOC IMMUNOLOGISTS. |
| 2013 | Brierley, S. M., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Poster session presented at the meeting of GUT. Glasgow, SCOTLAND: BMJ PUBLISHING GROUP. DOI |
| 2012 | Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders. DOI |
| 2012 | Hughes, P. A., Bird, D., Brierley, S. M., Persson, J., Moretta, M., Blackshaw, L. A., . . . Andrews, J. M. (2012). TNF-alpha from gut homing memory T cells and monocytes sensitises colonic sensory afferents in IBS-D. Poster session presented at the meeting of Neurogastroenterology and Motility: Supplement. Bologna, Italy: WILEY-BLACKWELL. |
| 2011 | Castro, J., Hughes, P. A., Martin, C. M., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. A., & Brierley, S. M. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL. |
| 2011 | Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J., . . . Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. Chicago, IL: W B Saunders Co. DOI |
| 2010 | Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing. DOI |
| 2010 | Mikocka-Walus, A. A., Bond, M., Holloway, R. H. H., Pilichiewicz, A., Persson, J., Collins, K., . . . Andrews, J. M. (2010). Cognitive behavioural therapy (CBT) as a treatment modality in inflammatory bowel disease (IBD): early experience and preliminary results. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY-BLACKWELL PUBLISHING, INC. WoS1 |
NHMRC
2016
Title: 1105028 -Neuroimmune interactions in functional and organic gastrointestinal diseases. Funding scheme: NHMRC - Career Development Fellowships. Investigators: Hughes P. Total Awarded Amount: AUD 419,180.
Title: 1085080 - Faecal Microbiota Transplantation for Active Ulcerative Colitis - a randomised controlled trial: clinical, microbial and immune outcomes. Funding scheme: NHMRC - Project Grants. Investigators: Andrews J, Hughes P, Conlon M, Roberts-Thomson I, Costello S, Knight R. Total Awarded Amount: AUD 675,896
2013
Title: Immune activation in functional gastrointestinal disorders. Funding scheme: NHMRC - Project Grants. Investigators: Hughes P (Sole CI). Total Awarded Amount: AUD 454,369
2010
Title: Viscerosensory neuroimmune interactions. Funding scheme:: NHMRC - Training Fellowships. Investigators: Hughes P. Total Awarded Amount: AUD 249,375
Industry (International / national)
2018- current: CMAX (Adelaide)
2015: Ironwood pharmaceuticals, USA
2012-2013: Tioga Pharmaceuticals, USA
NGO / philanthropic / University
2019
Title: Gut contents regulate symptoms in Irritable Bowel Syndrome. Funder name: Royal Adelaide Hospital Research Committee. Investigators: Hughes P, Andrews J. Total Awarded Amount: AUD 50,000.
2018
Title: The mechanisms underlying inflammation and pain differ between newly diagnosed and relapsing Ulcerative Colitis. Funder name: Royal Adelaide Hospital Research Committee NHMRC Near Miss Grants. Investigators: Hughes P. Total Awarded Amount: AUD 50,000
Philanthropic donation $9500.
2017
Title: Novel tools for imaging intestinal inflammation in-vivo Funder name: University of Adelaide project development funding. Investigators: Dr. Patrick Hughes, Nicole Dmochowska, Dr. William Tieu, Prab Takhar, Prof Andrew Abell, Dr. Marianne Keller. Total Awarded Amount: AUD 29268
2016
Title: Can immune activation explain symptom overlap in Irritable Bowel Syndrome and Inflammatory Bowel Disease in Remission? Funder name: Royal Adelaide Hospital Research Committee. Investigators: Hughes P, Andrews J. Total Awarded Amount: AUD 45,500
Title: Immune, microbiota and extrinsic nerve function differs between newly diagnosed and relapsing Ulcerative Colitis ion explain symptom overlap in Irritable Bowel Syndrome and Inflammatory Bowel Disease in Remission? Funder name: University of Adelaide seed project funding. Investigators: Hughes P. Total Awarded Amount: AUD 14,000
Title: Exploring the role of diet as an Adjunctive Therapy in Ulcerative Colitis (EAT-UC Study). Funder name: Royal Adelaide Hospital Research Committee. Investigators: Hughes P, Bryant R, Andrews J. Total Awarded Amount: AUD 18,640
2015
Title: Cognitive behavioural therapy modulates the immune system in inflammatory bowel disease patients. Investigators: Hughes P. Funder name: Royal Adelaide Hospital Research Committee. Total Awarded Amount: AUD 35,000
2014
Title: Identification of genetic pathways involved in immune activation in Irritable Bowel Syndrome. Funder name: Royal Adelaide Hospital Research Committee. Investigators: Hughes P. Total Awarded Amount: AUD 33,500.
2012
Title: Immune activation in functional gastrointestinal disorders - A pilot study. Funder name: Royal Adelaide Hospital Research Committee. Investigators: Hughes P. Total Awarded Amount: AUD 35,000.
Title: Immune activation in acute and relapsing colitis. Funder name: University of Adelaide new investigator grant. Investigators: Hughes P. Total Awarded Amount: $12000
Infrastructure
2018
Title: FHMS Infrastructure Grant - Live Cell Imager. Funder Name (Organisation): The University of Adelaide, Faculty of Health and Medical Sciences. Investigators: Bowen J, Wardill H, Hughes P, Worthley D, Woods S, Nassar Z, Yool A, Zannettino A. Total Awarded Amount: AUD 90,816
Title: FHMS Infrastructure Grant – Anaerobic chamber. Funder Name (Organisation): The University of Adelaide, Faculty of Health and Medical Sciences. Investigators: Young R, Lynn D, Costello S, Heilbron L, Wardill H, Bowen J, Hughes P, Page A. Total Awarded Amount: AUD 43,195
2017
Title: FHMS Infrastructure Grant – Ussing chamber. Funder Name (Organisation): The University of Adelaide, Faculty of Health and Medical Sciences. Investigators: Hughes P, Young R, Page A, Linz D. Total Awarded Amount: AUD 41,600
2015
Title: Laser microdissection facility. Funding scheme: ARC - Linkage Infrastructure, Equipment and Facilities. Investigators: Page A, Brierley S, Dear T, Hughes P, Keating D, Koblar S, Licinio J, Young R. Primary Fund Scheme Amount: AUD 170,000
PhD and honors projects are available for motivated students. Please contact Dr. Hughes for more information
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2018 - 2022 | Co-Supervisor | Exploring the Effects of Toll-Like Receptor 4 Antagonism on Gastrointestinal Mucositis and Tumour Activity | Doctor of Philosophy | Doctorate | Full Time | Miss Shu Yie Janine Tam |
| 2016 - 2020 | Principal Supervisor | Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease | Doctor of Philosophy | Doctorate | Full Time | Miss Nicole Dmochowska |
| 2013 - 2019 | Co-Supervisor | Faecal Microbiota Transplantation for the Treatment of Active Ulcerative Colitis | Doctor of Philosophy | Doctorate | Full Time | APrf Samuel Paul Costello |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2017 - ongoing | Council | Australasian Neurogastroenterology and Motility Association (ANGMA) | - | Australia |
| Date | Role | Membership | Country |
|---|---|---|---|
| 2015 - ongoing | Member | GENIEUR (Genes in Irritable Bowel Syndrome - European Network) | - |
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