Dr Patrick Hughes

Patrick Hughes
Postdoctoral
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Patrick Hughes

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

Connect with me

Dr Patrick Hughes

Dr Patrick Hughes

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

https://www.researchgate.net/profile/Patrick_Hughes6

 

 

Research Interests

Gastroenterology and Hepatology, Immunology, Neurosciences, Nutrition and Metabolic Health, Neuroscience, Behaviour and Brain Health, Surgical and Health Systems Innovation, Innovative Therapeutics

Journals

Year Citation
2018 Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M., Moraveji, S., Talmon, G. ... Barbara, G. (2018). Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30, 1, 1-13.
10.1111/nmo.13192
2017 Mavrangelos, C., Campaniello, M., Andrews, J., Bampton, P. & Hughes, P. (2017). Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome. Gut, Onlinepubl., 2, 314308-1-314308-3.
10.1136/gutjnl-2017-314308
2017 Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A. & Andrews, J. (2017). Cognitive-Behavioural Therapy for Inflammatory Bowel Disease: 24-Month Data from a Randomised Controlled Trial. International Journal of Behavioral Medicine, 24, 1, 127-135.
10.1007/s12529-016-9580-9
2017 Campaniello, M., Mavrangelos, C., Eade, S., Harrington, A., Blackshaw, L., Brierley, S. ... Hughes, P. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332.
10.1016/j.bbi.2016.11.015
2017 Mikocka-Walus, A., Hughes, P., Bampton, P., Gordon, A., Campaniello, M., Mavrangelos, C. ... Andrews, J. (2017). Fluoxetine for maintenance of remission and to improve quality of life in patients with Crohn's disease: a pilot randomised placebo-controlled trial. Journal of Crohn's & colitis, 11, 4, 509-514.
10.1093/ecco-jcc/jjw165
2016 Hughes, P., Costello, S., Bryant, R. & Andrews, J. (2016). Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications. American Journal of Physiology, 311, 3, G501-G513.
10.1152/ajpgi.00442.2015
2016 Campaniello, M., Harrington, A., Martin, C., Ashley Blackshaw, L., Brierley, S. & Hughes, P. (2016). Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterology and Motility, 28, 1, 54-63.
10.1111/nmo.12696
2016 Hughes, P. (2016). Sleeping in on pancreatic cancer pain: Schwann cell secreted IL-6 pushes snooze on the pain alarm. Gut, 65, 6, 897-898.
10.1136/gutjnl-2015-311272
2015 Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A. & Andrews, J. (2015). Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial. BMC Gastroenterology, 15, 1, 54-1-54-12.
10.1186/s12876-015-0278-2
2014 Hughes, P. A., Moretta, M., Lim, A., Grasby, D. J., Bird, D., Brierley, S. M. ... Krumbiegel, D. (2014). Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients.. Brain Behav Immun, 42, 191-203.
10.1016/j.bbi.2014.07.001
2014 Malsch, P., Andratsch, M., Vogl, C., Link, A., Alzheimer, C., Brierley, S. ... Kress, M. (2014). Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. Journal of Neuroscience, 34, 30, 9845-9856.
10.1523/JNEUROSCI.5161-13.2014
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D. ... Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62, 10, 1456-1465.
10.1136/gutjnl-2011-301856
2013 Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C. ... Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145, 6, 1334-1346.
10.1053/j.gastro.2013.08.017
2013 Blackshaw, L., Brierley, S., Harrington, A. & Hughes, P. (2013). TRP channels in visceral pain. The Open Pain Journal, 6, SPEC.ISSUE.1, 23-30.
10.2174/1876386301306010023
2013 Hughes, P., Zola, H., Penttila, I., Blackshaw, L., Andrews, J. & Krumbiegel, D. (2013). Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?. American Journal of Gastroenterology, 108, 7, 1066-1074.
10.1038/ajg.2013.120
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G. ... Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online, 7, 1-2.
10.1136/gutjnl-2013-306240
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J. & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520, 10, 2241-2255.
10.1002/cne.23042
2011 Hughes, P., Brierley, S. & Martin, C. (2011). Post-inflammatory colonic afferent sensitisation: Different subtypes, different pathways and different time courses (Gut (2009) 58, (1333-1341)). Gut, 60, 1, 140-.
10.1136/gut.2008.170811corr1
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G. & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589, 14, 3575-3593.
10.1113/jphysiol.2011.206789
2011 Blackshaw, L., Brierley, S., Hughes, P. & Harrington, A. (2011). The Hot Mustard Receptor's Role in Gut Motor Function. Gastroenterology, 141, 2, 423-427.
10.1053/j.gastro.2011.06.028
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N. ... Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152, 7, 1459-1468.
10.1016/j.pain.2011.01.027
2010 Blackshaw, L., Brierley, S. & Hughes, P. (2010). TRP channels: new targets for visceral pain. Gut, 59, 1, 126-135.
10.1136/gut.2009.179523
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G. & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3, 9, 2768-2798.
10.3390/ph3092768
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T. ... Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137, 6, 2084-2095.
10.1053/j.gastro.2009.07.048
2009 Hughes, P., Brierley, S., Martin, C., Liebregts, T., Persson, J., Adam, B. ... Blackshaw, L. (2009). TRPV1-expressing sensory fibres and IBS: links with immune function. Gut, 58, 3, 465-466.
10.1136/gut.2008.161760
2009 Hughes, P., Brierley, S., Martin, C., Brookes, S., Linden, D. & Blackshaw, L. (2009). Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut, 58, 10, 1333-1341.
10.1136/gut.2008.170811
2009 Hughes, P., Brierley, S. & Blackshaw, L. (2009). Post-inflammatory modification of colonic afferent mechanosensitivity. Clinical and Experimental Pharmacology and Physiology, 36, 10, 1034-1040.
10.1111/j.1440-1681.2009.05248.x
2008 Lindstrom, E., Brusberg, M., Hughes, P., Martin, C., Brierley, S., Phillis, B. ... Blackshaw, L. (2008). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain, 137, 2, 295-305.
10.1016/j.pain.2007.09.008
2008 Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N. ... Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134, 7, 2059-2069.
10.1053/j.gastro.2008.01.074
2007 Hughes, P., Brierley, S., Young, R. & Blackshaw, L. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology, 500, 5, 863-875.
10.1002/cne.21204
2007 Page, A., Brierley, S., Martin, C., Hughes, P. & Blackshaw, L. (2007). Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain, 133, 1-3, 150-160.
10.1016/j.pain.2007.03.019
2006 Callaghan, P., Farrand, K., Salem, A., Hughes, P., Daws, L. & Irvine, R. (2006). Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European Journal of Pharmacology, 546, 1-3, 74-81.
10.1016/j.ejphar.2006.07.011
2004 DeLaLande, I., Stepien, J., Philpott, A., Hughes, P., Stafford, I. & Horowitz, J. (2004). Aldehyde dehrdrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. European Journal of Pharmacology, 496, 1, 141-149.
10.1016/j.ejphar.2004.06.010

Book Chapters

Year Citation
2012 Brierley, S., Hughes, P., Harrington, A. & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. R. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (pp. 703-729). United Kingdom: Elsevier.
10.1016/B978-0-12-382026-6.00024-5
2012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A. & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (pp. 379-390). USA: Springer.
10.1007/978-1-62703-095-3_23

Conference Papers

Year Citation
2010 Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C. & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation.
10.1016/S0016-5085(10)60626-9
2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S. & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. Congress of the International Society for Autonomic Neuroscience - ISAN. Sydney, Australia.
10.1016/j.autneu.2009.05.028
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K. ... Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. TRP channel Meeting Stockholm. Sweden.

Conference Items

Year Citation
2017 Wardill, H. R., Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Bowen, J. M., Andrews, J. M. ... Hughes, P. A. (2017). Fecal Supernatants from Active Ulcerative Colitis Patients Impair Colonic Epithelial Barrier Integrity and Activate Pelvic Mucosal Extrinsic Afferent Nerves. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting. Chicago, IL.
2013 Hughes, P., Moretta, M., Bird, D., Grasby, D., Lim, A., Brierley, S. ... Krumbiegel, D. (2013). Beta-endorphin secretion by monocyte/macrophages is deficient in irritable bowel syndrome: a contributor to visceral hypersensitivity?.
2012 Hughes, P., Bird, D., Brierley, S., Persson, J., Moretta, M., Blackshaw, L. ... Andrews, J. (2012). TNF-alpha from gut homing memory T cells and monocytes sensitises colonic sensory afferents in IBS-D.
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D. ... Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Digestive Disease Week. San Diego.
10.1016/S0016-5085(12)62702-4
2011 Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J. ... Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity.
2011 Hughes, P. A., Harrington, A. M., Brierley, S. M., Maldeniya, L., Martin, C., Persson, J. ... Blackshaw, L. A. (2011). Cytokine modulation of visceral afferents via cation channels is switches in chronic visceral hypersensitivity.
10.1016/S0016-5085(11)60534-9
2011 Castro, J., Hughes, P., Martin, C., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. & Brierley, S. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice.
2010 Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P. & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Joint International Neurogastroenterology and Motility Meeting, NGM. Boston, MA, USA.
10.1111/j.1365-2982.2010.01549.x

NHMRC:

2016-2019: NHMRC R.D. Wright Biomedical Fellowship

2015-2017: NHMRC projecct grant 1085080 "Faecal Microbiota Transplantation for Active
Ulcerative Colitis - a randomised controlled trial: clinical, microbial & immune outcomes". $675,986. 2015-2017. Andrews, Hughes, Conlon, Roberts-Thompson, Costello (CIB)

2013-2015:   NHMRC project grant 1042952 “Immune activation in functional gastrointestinal disorders”. $454,369.21. 2013-2015. CIA (Sole CI).

2010-2014:   NHMRC Biomedical Training Fellowship 614805 “Viscerosensory neuroimmune interactions”. $285,000. 2010-2014. CIA

2011-2013:   NHMRC project grant 1008100 “Ion channels underlying inflammatory and postinflammatory visceral mechanical hypersensitivity” $436,299. 2011-2013. AI

 

Other competitive funding schemes:

2016: University of Adelaide seed project funding. $14000 CIA

2016: RAH clinical research grant "Can immune activation explain symptom overlap in Irritable Bowel Syndrome and Inflammatory Bowel Disease in Remission?" 45,500 CIA.

2015: RAH clinical research grant. "Cognitive Behavioural Therapy moudlates the immune system in Inflammatory Bowel Disease patients" $32,000 CIA.

2014: RAH clinical research grant. "Identification of genetic pathways involved in immune activation in Irritable Bowel Syndrome" $35,000. CIA

2012: University of Adelaide Faculty of Health Science New Investigator grant “Immune activation in acute and relapsing colitis”  2012. CIA

2012: RAH clinical project grant “Immune activation in functional gastrointestinal disorders – a pilot study”  2012 CIA

2011: Princess Alexandra Hospital Research Foundation and Private Practice Trust Fund. “The role of the gastrointestinal tract microbiota and chronic infections in irritable bowel syndrome” 2011. CIB

PhD and honors projects are available for motivated students. Please contact Dr. Hughes for more information

Nicole Dmochowska - PhD student

Memberships

Date Role Membership Country
2015 - ongoing Member GENIEUR (Genes in Irritable Bowel Syndrome - European Network)

Committee Memberships

Date Role Committee Institution Country
2017 - ongoing Council Australasian Neurogastroenterology and Motility Association (ANGMA) Australia
Position
Postdoctoral
Phone
81284843
Fax
8222 5934
Campus
North Terrace
Org Unit
Medicine

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