Dr Patrick Hughes

Patrick Hughes
Postdoctoral
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Patrick Hughes

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

Connect With Me

Dr Patrick Hughes

Dr Patrick Hughes

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

Dr. Hughes is interested in understanding how the nervous and immune system communicate, the role that microbiota has in mediating these interactions and the development of new tools for imaging these interactions. He investigates these interactions in diseases of the lower gastrointestinal tract, particularly Inflammatory Bowel Disease and Irritable Bowel Syndrome. These diseases are associated with pronounced changes to microbiota, immune function and nervous signalling, but it is currently not clear how these changes relate to symptoms. Dr. Hughes' research has a strong translational aspect, with close collaborations with gastroenterologists based throughout the wider Adelaide area.

https://www.researchgate.net/profile/Patrick_Hughes6

 

 

Journals

Year Citation
2018 Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M., Moraveji, S., Talmon, G., . . . Barbara, G. (2018). Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 30(1), 1-13.
DOI Scopus1 Europe PMC2
2018 Guerrero-Alba, R., Valdez-Morales, E., Jiménez-Vargas, N., Bron, R., Poole, D., Reed, D., . . . Vanner, S. (2018). Co-expression of μ and ∂ opioid receptors by mouse colonic nociceptors.. British journal of pharmacology.
DOI
2017 Mavrangelos, C., Campaniello, M., Andrews, J., Bampton, P., & Hughes, P. (2017). Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome. Gut, Onlinepubl.(2), 314308-1-314308-3.
DOI Scopus1 WoS1 Europe PMC1
2017 Mikocka-Walus, A., Hughes, P., Bampton, P., Gordon, A., Campaniello, M., Mavrangelos, C., . . . Andrews, J. (2017). Fluoxetine for maintenance of remission and to improve quality of life in patients with Crohn's disease: a pilot randomised placebo-controlled trial. Journal of Crohn's & colitis, 11(4), 509-514.
DOI Scopus3 WoS3 Europe PMC3
2017 Campaniello, M., Mavrangelos, C., Eade, S., Harrington, A., Blackshaw, L., Brierley, S., . . . Hughes, P. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332.
DOI Scopus1 WoS1 Europe PMC1
2017 Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2017). Cognitive-Behavioural Therapy for Inflammatory Bowel Disease: 24-Month Data from a Randomised Controlled Trial. International Journal of Behavioral Medicine, 24(1), 127-135.
DOI Scopus5 WoS3 Europe PMC1
2016 Hughes, P., Costello, S., Bryant, R., & Andrews, J. (2016). Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications. American Journal of Physiology, 311(3), G501-G513.
DOI Scopus6 WoS3 Europe PMC2
2016 Campaniello, M., Harrington, A., Martin, C., Ashley Blackshaw, L., Brierley, S., & Hughes, P. (2016). Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterology and Motility, 28(1), 54-63.
DOI Scopus5 WoS6 Europe PMC5
2016 Hughes, P. (2016). Sleeping in on pancreatic cancer pain: Schwann cell secreted IL-6 pushes snooze on the pain alarm. Gut, 65(6), 897-898.
DOI
2015 Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2015). Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial. BMC Gastroenterology, 15(1), 54-1-54-12.
DOI Scopus17 WoS14 Europe PMC8
2014 Malsch, P., Andratsch, M., Vogl, C., Link, A., Alzheimer, C., Brierley, S., . . . Kress, M. (2014). Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. Journal of Neuroscience, 34(30), 9845-9856.
DOI Scopus15 WoS13 Europe PMC11
2014 Hughes, P., Moretta, M., Lim, A., Grasby, D., Bird, D., Brierley, S., . . . Krumbiegel, D. (2014). Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain, Behavior, and Immunity, 42, 191-203.
DOI Scopus21 WoS18 Europe PMC15
2013 Blackshaw, L., Brierley, S., Harrington, A., & Hughes, P. (2013). TRP channels in visceral pain. The Open Pain Journal, 6(SPEC.ISSUE.1), 23-30.
DOI Scopus2
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2.
DOI Scopus21 WoS20 Europe PMC18
2013 Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., . . . Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145(6), 1334-1346.
DOI Scopus88 WoS76 Europe PMC63
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465.
DOI Scopus83 WoS73 Europe PMC64
2013 Hughes, P., Zola, H., Penttila, I., Blackshaw, L., Andrews, J., & Krumbiegel, D. (2013). Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?. American Journal of Gastroenterology, 108(7), 1066-1074.
DOI Scopus64 WoS56 Europe PMC46
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255.
DOI Scopus23 WoS22 Europe PMC18
2011 Blackshaw, L., Brierley, S., Hughes, P., & Harrington, A. (2011). The Hot Mustard Receptor's Role in Gut Motor Function. Gastroenterology, 141(2), 423-427.
DOI Scopus5 WoS5 Europe PMC4
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593.
DOI Scopus69 WoS61 Europe PMC42
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468.
DOI Scopus70 WoS64 Europe PMC55
2011 Hughes, P., Brierley, S., & Martin, C. (2011). Post-inflammatory colonic afferent sensitisation: Different subtypes, different pathways and different time courses (Gut (2009) 58, (1333-1341)). Gut, 60(1), 140.
DOI
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798.
DOI Scopus7 Europe PMC3
2010 Blackshaw, L., Brierley, S., & Hughes, P. (2010). TRP channels: new targets for visceral pain. Gut, 59(1), 126-135.
DOI Scopus48 WoS40 Europe PMC36
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus155 WoS140 Europe PMC108
2009 Hughes, P., Brierley, S., & Blackshaw, L. (2009). Post-inflammatory modification of colonic afferent mechanosensitivity. Clinical and Experimental Pharmacology and Physiology, 36(10), 1034-1040.
DOI Scopus37 WoS33 Europe PMC29
2009 Hughes, P., Brierley, S., Martin, C., Brookes, S., Linden, D., & Blackshaw, L. (2009). Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut, 58(10), 1333-1341.
DOI Scopus86 WoS78 Europe PMC72
2009 Hughes, P., Brierley, S., Martin, C., Liebregts, T., Persson, J., Adam, B., . . . Blackshaw, L. (2009). TRPV1-expressing sensory fibres and IBS: links with immune function. Gut, 58(3), 465-466.
DOI Scopus35 WoS30 Europe PMC10
2008 Lindstrom, E., Brusberg, M., Hughes, P., Martin, C., Brierley, S., Phillis, B., . . . Blackshaw, L. (2008). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain, 137(2), 295-305.
DOI Scopus48 WoS37 Europe PMC29
2008 Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069.
DOI Scopus150 WoS135 Europe PMC115
2007 Page, A., Brierley, S., Martin, C., Hughes, P., & Blackshaw, L. (2007). Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain, 133(1-3), 150-160.
DOI Scopus43 WoS33 Europe PMC29
2007 Hughes, P., Brierley, S., Young, R., & Blackshaw, L. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology, 500(5), 863-875.
DOI Scopus63 WoS56 Europe PMC51
2006 Callaghan, P., Farrand, K., Salem, A., Hughes, P., Daws, L., & Irvine, R. (2006). Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European Journal of Pharmacology, 546(1-3), 74-81.
DOI WoS6 Europe PMC5
2004 DeLaLande, I., Stepien, J., Philpott, A., Hughes, P., Stafford, I., & Horowitz, J. (2004). Aldehyde dehrdrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. European Journal of Pharmacology, 496(1), 141-149.
DOI Scopus17 WoS16 Europe PMC11

Book Chapters

Conference Papers

Conference Items

Year Citation
2017 Wardill, H., Dmochowska, N., Campaniello, M., Mavrangelos, C., Bowen, J., Andrews, J., . . . Hughes, P. (2017). Fecal supernatants from active ulcerative colitis patients impair colonic epithelial barrier integrity and activate pelvic mucosal extrinsic afferent nerves. Poster session presented at the meeting of FASEB Journal. Chicago, IL: Federation of American Societies for Experimental Biology.
2013 Hughes, P., Moretta, M., Bird, D., Grasby, D., Lim, A., Brierley, S., . . . Krumbiegel, D. (2013). Beta-endorphin secretion by monocyte/macrophages is deficient in irritable bowel syndrome: a contributor to visceral hypersensitivity?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders.
DOI
2012 Hughes, P., Bird, D., Brierley, S., Persson, J., Moretta, M., Blackshaw, L., . . . Andrews, J. (2012). TNF-alpha from gut homing memory T cells and monocytes sensitises colonic sensory afferents in IBS-D. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2011 Castro, J., Hughes, P., Martin, C., Silos-Santiago, A., Kurtz, C., Black-Shaw, L., & Brierley, S. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2011 Hughes, P. A., Harrington, A. M., Brierley, S. M., Maldeniya, L., Martin, C., Persson, J., . . . Blackshaw, L. A. (2011). Cytokine modulation of visceral afferents via cation channels is switches in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. WB Saunders.
DOI
2011 Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J., . . . Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. W B Saunders Co.
2010 Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing.
DOI

NHMRC:

2016-2019: NHMRC R.D. Wright Biomedical Fellowship

2015-2017: NHMRC projecct grant 1085080 "Faecal Microbiota Transplantation for Active
Ulcerative Colitis - a randomised controlled trial: clinical, microbial & immune outcomes". $675,986. 2015-2017. Andrews, Hughes, Conlon, Roberts-Thompson, Costello (CIB)

2013-2015:   NHMRC project grant 1042952 “Immune activation in functional gastrointestinal disorders”. $454,369.21. 2013-2015. CIA (Sole CI).

2010-2014:   NHMRC Biomedical Training Fellowship 614805 “Viscerosensory neuroimmune interactions”. $285,000. 2010-2014. CIA

2011-2013:   NHMRC project grant 1008100 “Ion channels underlying inflammatory and postinflammatory visceral mechanical hypersensitivity” $436,299. 2011-2013. AI

 

Other competitive funding schemes:

2016: University of Adelaide seed project funding. $14000 CIA

2016: RAH clinical research grant "Can immune activation explain symptom overlap in Irritable Bowel Syndrome and Inflammatory Bowel Disease in Remission?" 45,500 CIA.

2015: RAH clinical research grant. "Cognitive Behavioural Therapy moudlates the immune system in Inflammatory Bowel Disease patients" $32,000 CIA.

2014: RAH clinical research grant. "Identification of genetic pathways involved in immune activation in Irritable Bowel Syndrome" $35,000. CIA

2012: University of Adelaide Faculty of Health Science New Investigator grant “Immune activation in acute and relapsing colitis”  2012. CIA

2012: RAH clinical project grant “Immune activation in functional gastrointestinal disorders – a pilot study”  2012 CIA

2011: Princess Alexandra Hospital Research Foundation and Private Practice Trust Fund. “The role of the gastrointestinal tract microbiota and chronic infections in irritable bowel syndrome” 2011. CIB

PhD and honors projects are available for motivated students. Please contact Dr. Hughes for more information

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2016 Principal Supervisor Characterising the immune profile in Inflammatory Bond Disease using novel in-vivo imaging technologies. Doctor of Philosophy Doctorate Full Time Miss Nicole Dmochowska

Memberships

Date Role Membership Country
2015 - ongoing Member GENIEUR (Genes in Irritable Bowel Syndrome - European Network)

Committee Memberships

Date Role Committee Institution Country
2017 - ongoing Council Australasian Neurogastroenterology and Motility Association (ANGMA) Australia
Position
Postdoctoral
Phone
81284843
Fax
8222 5934
Campus
North Terrace
Org Unit
Medicine

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