School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Alsharifi studied Biomedical Science at Monash University. After graduating with First Class Honours, he moved to the Australian National University to take up a PhD scholarship at The John Curtin School of Medical Research (JCSMR). During his PhD, he investigated with Prof Arno Müllbacher, Prof Robert Blanden, and Dr Mario Lobigs the immunobiology of an alphavirus infection. Based on his PhD research, he published many papers describing some important concepts related to type-I interferon responses following an acute primary viral infection and the increased risk to a more sever secondary viral and/or bacterial infection. Following the completion of his PhD, he remained at the JCSMR as postdoctoral fellow to investigated with Prof Müllbacher the use of γ-irradiated influenza preparations as a universal flu vaccine candidate, funded by the NHMRC. This work resulted in multiple patents and the establishment of a biotech company (Gamma Vaccine Pty Ltd). In 2008, he was awarded the Hanson Fellowship to established an independent research group and to continue his research into the universal Flu vaccine and also the possibility of producing other vaccines using similar technique. In 2010, he relocated his group to the School of Biological Science/ The University of Adelaide and in collaboration with James Paton attracted funding from ARC and NHMRC to develop a single vaccine for influenza and pneumonia with “Gamma Vaccines Pty Ltd” as the Commercial Partner Organisation. This work resulted in patentable IP surrounding a novel pneumococcal whole cell vaccine and the formation of "GPN Vaccines Pty Ltd". In addition, he had been invited by the International Atomic Energy Agency (IAEA) as a technical expert to take part in IAEA’s coordinated research program to investigate the use of gamma-ray inactivation of pathogens for vaccine purposes.
Many of Dr Alsharifi's work has been published in high ranked peer-reviewed scientific journals and his flu vaccine research has been featured in the Catalyst program on ABC (http://www.abc.net.au/catalyst/stories/2613604.htm), and in many newspaper articles such as (http://www.news.com.au/adelaidenow/story/0,,25625291-5018662,00.html) and (http://www.news.com.au/adelaidenow/story/0,22606,25406694-5006301,00.html).
Date Position Institution name 2016 - ongoing Senior Lecturer University of Adelaide 2013 - 2015 Visiting Professor Management and Science University 2012 - 2016 Lecturer University of Adelaide 2010 - 2012 Research Fellow University of Adelaide
Language Competency Arabic English
Date Institution name Country Title 2005 Australian National University Australia Ph.D 2004 Australian National University Australia Certificate (with merit) in graduate teaching 2001 Monash University Australia Bachelor of Biomedical Science (Honours, Class I)
Date Title Institution Country 2008 - 2010 RRC Research Fellow SA Health Australia 2005 - 2007 Postdoctoral fellow Australian National University Australia
Year Citation 2016 David, S., Paton, J., McColl, S., & Alsharifi, M. (2016). Gamma-irradiated influenza A virus vaccine: irradiation conditions & vaccine efficacy. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 1236). Melbourne, AUSTRALIA: WILEY-BLACKWELL. 2007 Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., & Muellbacher, A. (2007). Interferon type-I responses in primary and secondary viral infections. In CYTOKINE Vol. 39 (pp. 1). San Francisco, CA: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD.
2005 Alsharifi, M., Lobigs, M., Regner, M., Koskinen, E. L. A., & Mullbacher, A. (2005). Exhaustion of type-I interferon response following an acute viral infection. In TISSUE ANTIGENS Vol. 66 (pp. 345-346). Melbourne, AUSTRALIA: BLACKWELL PUBLISHING.
Year Citation 2019 David, S. C., Laan, Z., Chen, A., Hirst, T., Paton, J., & Alsharifi, M. (2019). A novel co-vaccination strategy to provide serotype-independent protection against pneumococcal infections. Poster session presented at the meeting of 14th European Meeting on the Molecular Biology of the Pneumococcus (Europneumo). Greifswald, Germany. 2019 David, S. C., Singleton, E., Laan, Z., Chen, A., Hirst, T., Comerford, I., . . . Alsharifi, M. (2019). A novel co-vaccination strategy for cross-reactive immunity against influenza A & pneumococcal infections. Poster session presented at the meeting of Australian & New Zealand Society for Immunology (ASI) Meeting. Adelaide, Australia. 2018 David, S. C., Babb, R., McColl, S., Paton, J., & Alsharifi, M. (2018). Bi-directional adjuvant activity of co-administered pneumococcal and influenza A vaccines. Poster session presented at the meeting of International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11). Melbourne, Australia. 2017 David, S. C., Paton, J., McColl, S., & Alsharifi, M. (2017). Enhancement of influenza-specific immunity following intranasal co-administration of whole inactivated Influenza and pneumococcal vaccines. Poster session presented at the meeting of Australian Virology Society (AVS). 2016 David, S. C., Lau, J., Singleton, E., Paton, J., McColl, S., & Alsharifi, M. (2016). THE EFFECT OF GAMMA-IRRADIATION CONDITIONS ON THE IMMUNOGENICITY OF WHOLE-INACTIVATED INFLUENZA A VIRUS VACCINE. Poster session presented at the meeting of Adelaide Immunology Retreat (AIR-12) Meeting. Adelaide, Australia. 2016 Fenix, K., Kara, E., Bastow, C., Gregor, C., McKenzie, D., Norton, T., . . . McColl, S. (2016). CCR2 Is critical for memory CD8 T cell generation following influenza A virus infection. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.
Year Citation 2021 David, S., Alsharifi, M., Brazel, E., Hirst, T., & Paton, J. (2021). US20210361758A1, Streptococcal vaccines and methods for use. US. 2021 Brazel, E., Alsharifi, M., David, S., Hirst, T., & Paton, J. (2021). US20210361757A1, Streptococcal vaccine formulations and uses thereof. US. 2016 Alsharifi, M., Babb, R., Chen, A. Y., David, S. C., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2016). 050231, Streptococcal Vaccine. Australia. 2015 Alsharifi, M., Babb, R., Chen, A. Y., Hirst, T. R., Ogunniyi, A. D., & Paton, J. C. (2015). 2015901098, Streptococcal Vaccine. Australia.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Immune responses induced by inactivated bacterial and viral vaccines. Master of Philosophy Master Full Time Ms Yimin Chuah 2022 Principal Supervisor Immune responses induced by inactivated vaccines Master of Philosophy Master Full Time Miss Mariana Couto Moniz 2020 Principal Supervisor Influenza A Virus Vaccine Development Doctor of Philosophy Doctorate Full Time Ms Chloe Gates
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2020 Principal Supervisor Humoral responses induced by an enzymatically active, whole-cell killed pneumococcal vaccine Master of Philosophy Master Full Time Miss Zoe Laan 2017 - 2020 Principal Supervisor Sterility and Immunogenicity of Gamma Irradiated Respiratory Viruses Doctor of Philosophy Doctorate Full Time Miss Eve Victoria Singleton 2016 - 2018 Principal Supervisor Enhancement of pathogen-specific immunity following co-administration of whole inactivated respiratory vaccines Doctor of Philosophy Doctorate Full Time Dr Shannon Christa David 2014 - 2014 Co-Supervisor Chikungunya Virus: Evidence for Global Policy, Practice and Research in Disease Management, Surveillance and Mosquito Control Doctor of Philosophy Doctorate Full Time Miss Zhili Chen 2013 - 2017 Co-Supervisor The role of chemokine receptors CCR2 and CXCR5 in CD8 positive T cell biology Doctor of Philosophy Doctorate Full Time Dr Kevin Aaron Fenix 2012 - 2017 Principal Supervisor Development of a Novel Co-vaccination Approach for Pneumococcal and Influenza Infections Doctor of Philosophy Doctorate Full Time Miss Rachelle Babb 2012 - 2013 Principal Supervisor Pre-existing strain specific neutralising antibodies abrogates the induction of interferon type I and cytotoxic T cell responses to subsequent homotypic influenza A virus challenge Master of Philosophy Master Full Time Miss Jennifer Chan
Date Role Editorial Board Name Institution Country 2012 - ongoing Editor PLoS One
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