Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Kevin Fenix is a The Hospital Research Foundation Early Career Postdoctoral Research Fellow (2018) working on finding new treatments and prognostics for bowel cancer patients. He has an immunology background completing his PhD in 2017.
Colorectal cancer (CRC) commonly known as bowel cancer is the second most common form of cancer in Australia and the third most common cancer world-wide. In Australia, it costs at least 1 billion dollars per year to try to treat this disease. Every year, it is predicted that 17,000 Australians will be diagnosed with CRC and 4,000 Australians will succumb to this disease. The majority of people who die from bowel cancer, die because the cancer metastasizes and spreads to the liver. This increases the patient’s mortality rate from 30% to 70%. Critically, patients who have undergone surgical removal (resection) of liver metastasized-tumours will most-likely (90%) re-develop liver metastasis. What’s even more alarming is that the incidence of young people (age 20-39) being diagnosed with CRC has been increasing by 1-2% per year since 1990. Patients diagnosed with CRC at a young age (<55) are 58% more likely to be diagnosed with metastatic CRC than older people. At present, there are no effective tools to predict a CRC patient’s risk of developing liver metastasis and for liver-resected CRC patient’s risk of re-developing liver metastasis. Current treatments are insufficient in controlling CRC once it has metastasized. Thus, there is an urgent clinical need to (1) define improved diagnostic markers for metastatic CRC to reduce death rates by identifying metastasizing cancers earlier and to (2) identify improved treatments that can prevent the spread of CRC to the liver and treat existing liver metastasis.
Located at the Basil Hetzel Institute for Translational Health Research with direct links to the Queen Elizabeth Hospital, my research utilizes both patient samples and clinically relevant in vitro and in vivo models to address these needs. My research focuses on:
- Identifying distinct tumour-infiltrating immune cells with prognostic capacity for CRC liver metastasis and survival.
- Characterizing novel tumour-infiltrating immune cell subsets by advanced proteomic and transcriptomic approaches.
- Understanding how immune cells shape tumour progression.
Date Position Institution name 2018 THRF Early Career Postdoctoral Research Fellow The University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Fellowship The Hospital Research Foundation Early Career Fellowship The Hospital Research Foundation Australia — 2017 Award Dean’s Commendation for Thesis Excellence The University of Adelaide Australia — 2012 Scholarship Australian Postgraduate Award The University of Adelaide Australia — 2010 Research Award Derrick Rowley Prize for Honours in Microbiology and Immunology The University of Adelaide Australia —
Language Competency English Can read, write, speak, understand spoken and peer review Filipino; Pilipino Can read, write, speak and understand spoken
Date Institution name Country Title 2017 University of Adelaide Australia PhD 2010 University of Adelaide, Adelaide Australia Bsc (Hons) 2009 University of Adelaide, Adelaide Australia Bsc (Biomedical Science)
Year Citation 2017 Gregor, C., Kara, E., Fenix, K., McKenzie, D., Comerford, I., & McColl, S. (2017). Effector T helper cell recruitment to inflammatory sites via CCR2. In SWISS MEDICAL WEEKLY Vol. 147 (pp. 64S). E M H SWISS MEDICAL PUBLISHERS LTD.
Pre-clinical assessment of a patient-derived cellular immunotherapy for metastatic colorectal cancer.
|2019||Construction of the South Australian Liver Tissue-Biobank (SALT) for discovery and development of prognostic biomarkers of colorectal cancer liver metastasis. (Beat Cancer SA and The Hospital Research Foundation)||Maddern G., Fenix K.||$200,000|
|2019||Purchase of a fluorescent and bright-field automated cell counter. (Faculty of Health and Medical Sciences Research Infrastructure Funding Award and The Basil-Hetzel Institute Research Equipment Award)||Maddern G., Fenix K., Wormald P., Grubor-Bauk B.||$22,703|
|2018||Study of bioactivity of Hengshan Astragalus Shiitake as biological response modifiers in cancer therapy ( Flinders University Innovation Patnership Seed Grant and Shanxi Yulongxiang agricultural development Co., Ltd)||Ma L., Fenix K., Hauben E., Liang Q.||$100,000|
Identification of a Diagnostic Marker for Assessment and Management of Psoriasis. ( New Adventures Fund UniSA and The Hospital Research Foundation )
Grubor-Bauk B., Wijesundara D., Fenix K., Kopecki Z.
|2018||Using Tissue-Resident T cells to develop new prognostics and treatments against bowel cancer. ( The Hospital Research Foundation Early Career Fellowship)||Fenix K.||$240,000|
|2019||Faculty of Health and Medical Sciences||Lorne Cancer Conference (2019)||$1000|
|2017||Australasian Society for Immunology||46th Annual Scientific Meeting of Australasian Society for Immunology (Brisbane, Australia)||$1400|
|2016||International Congress of Immunology||International Congress of Immunology 2016 (Melbourne, Australia)||$1000|
|2014||School of Molecular and Biomedical Science and Australasian Society for Immunology||Annual Scientific Meeting of Australasian Society for Immunology (Wollongong, Australia)||$1500|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 Co-Supervisor Investigating Cytokine Induced Killer Cell Therapy in Colorectal Cancer Liver Metastatic Disease Doctor of Philosophy Doctorate Full Time Miss Man Ying Li
Date Role Committee Institution Country 2019 - ongoing Member BHI IBC Biosafety Committee BHI Australia 2018 - ongoing Member Basil-Hetzel Institute Management Committee Basil-Hetzel Institute for Translational Health Research Australia 2017 - ongoing Member Adelaide Immunology Retreat Organzing Committee Australasian Soceity for Immunology Australia 2017 - ongoing Member Day of Immunology (Adelaide) Organizing Committee Australsian Society for Immunology Australia
Date Role Membership Country 2018 - ongoing Member Australasian Cytometry Society Australia 2018 - ongoing Member Australasian Gastro-Intestinal Trials Group Australia 2018 - ongoing Member Cancer Voices SA Australia 2013 - ongoing Member Australasian Society for Immunology Australia
Date Title Engagement Type Institution Country 2018 - ongoing Invited Speaker for The Longest Table Events Public Community Engagement The Hospital Research Foundation Australia 2018 - ongoing Science Alive! Booth Volunteer (BHI) Public Community Engagement Basil Hetzel Institute for Translational Health Research Australia 2018 - ongoing Newsletter Article in The Hospital Research Foundation Public Community Engagement The Hospital Research Foundation — 2018 - ongoing Radio Interview for Coast FM Public Community Engagement The Hospital Research Foundation Australia 2018 - ongoing Invited Speaker for the Day of Immunology BHI Lab Tour Public Community Engagement Australasian Society for Immunology Australia
Date Role Editorial Board Name Institution Country 2018 - ongoing Editor Frontiers in Cellular and Infection Microbiology The University of Adelaide Australia
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