Associate Professor Michael Lardelli

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• Appointments

  Date	Position	Institution name
  2015	Associate Professor in Genetics	University of Adelaide

• Language Competencies

  Language	Competency
  English	Can read, write, speak, understand spoken and peer review
  Swedish	Can read, write, speak and understand spoken

• Education

  Date	Institution name	Country	Title
  1987 - 1991	Council for National Academic Awards	United Kingdom	Ph.D.
  1981 - 1984	University of Sydney	Australia	B.Sc. (Hons)

• Postgraduate Training

  Date	Title	Institution	Country
  1994 - 1995	ESF Postdoctoral Fellowship	Uppsala University	Sweden
  1991 - 1994	EMBO Long Term Postodoctoral Fellowship	Karolinska Institute	Sweden

• Research Interests

  Animal Developmental Cell Metabolism Cellular Nervous System Central Nervous System Developmental Genetics Genetically Modified Animals Genetics Genomics Medical Genetics Molecular Evolution Neurogenetics Transgenesis

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• Journals

  Year	Citation
  2019	Newman, M., Moussavi Nik, H., Sutherland, G., Kim, W., Halliday, G., Jayadev, S., . . . Lardelli, M. (2019). Accelerated loss of hypoxia response and biased allele expression in zebrafish with Alzheimer's disease-like mutations. DOI
  2019	Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production. DOI
  2019	Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular Brain, 12(1), 1-5. DOI
  2019	Braggin, J., Bucks, S., Course, M., Smith, C., Sopher, B., Osnis, L., . . . Jayadev, S. (2019). Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology, 6(4), 762-777. DOI
  2018	Lumsden, A., Rogers, J., Majd, S., Newman, M., Sutherland, G., Verdile, G., & Lardelli, M. (2018). Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease. Frontiers in Neuroscience, 12(AUG), 533-1-533-21. DOI Scopus3 WoS4 Europe PMC2
  2018	Nik, S. H. M., Newman, M., Lumsden, A., Jayne, T., & Lardelli, M. (2018). HMGA1 zebrafish co-orthologue hmga1b can modulate p53-dependent cellular responses but is unable to control the alternative splicing of psen1. DOI
  2018	Jiang, H., Newman, M., & Lardelli, M. (2018). The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. PLoS ONE, 13(10), e0206155-1-e0206155-20. DOI Scopus1 WoS1
  2018	Jiang, H., Jayadev, S., Lardelli, M., & Newman, M. (2018). A Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1. Journal of Alzheimer's Disease, 66(4), 1323-1339. DOI
  2018	Ratnayake, D., Newman, M., & Lardelli, M. (2018). Degenerate codon mixing for PCR-based manipulation of highly repetitive sequences. BMC Research Notes, 11(1), 202-1-202-7. DOI
  2018	Hin, N., Newman, M., Kaslin, J., Douek, A., Lumsden, A., Zhou, X., . . . Lardelli, M. (2018). Accelerated brain aging towards transcriptional inversion in a zebrafish model of familial Alzheimer's disease. BioRxiv, OnlinePubl. DOI
  2017	Newman, M., Halter, L., Lim, A., & Lardelli, M. (2017). Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer’s disease. PLoS ONE, 12(6), e0179859-1-e0179859-17. DOI
  2016	Ebrahimie, E., Moussavi Nik, S., Newman, M., Van Der Hoek, M., & Lardelli, M. (2016). The Zebrafish equivalent of Alzheimer's disease-associated PRESENILIN Isoform PS2V regulates inflammatory and other responses to hypoxic stress. Journal of Alzheimer's Disease, 52(2), 581-608. DOI Scopus8 WoS7 Europe PMC7
  2016	Jayne, T., Newman, M., Verdile, G., Sutherland, G., Münch, G., Musgrave, I., . . . Lardelli, M. (2016). Evidence for and against a pathogenic role of reduced γ-secretase activity in familial Alzheimer's disease. Journal of Alzheimer's Disease, 52(3), 781-799. DOI Scopus11 WoS10 Europe PMC8
  2016	Richards, R., Robertson, S., O'Keefe, L., Fornarino, D., Scott, A., Lardelli, M., & Baune, B. (2016). The enemy within: innate surveillance-mediated cell death, the common mechanism of neurodegenerative disease. Frontiers in Neuroscience, 10(MAY), 193-1-193-20. DOI Scopus17 WoS17 Europe PMC14
  2015	Moussavi Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., . . . Lardelli, M. (2015). Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678. DOI Scopus13 WoS11 Europe PMC6
  2015	Lim, A., Moussavi Nik, S., Ebrahimie, E., & Lardelli, M. (2015). Analysis of nicastrin gene phylogeny and expression in zebrafish. Development Genes and Evolution, 225(3), 171-178. DOI Scopus2 WoS2 Europe PMC1
  2014	Newman, M., Ebrahimie, E., & Lardelli, M. (2014). Using the zebrafish model for Alzheimer's disease research. Frontiers in Genetics, 5(JUN), 189-1-189-10. DOI Scopus44 WoS41 Europe PMC25
  2014	Ganesan, S., Moussavi Nik, S., Newman, M., & Lardelli, M. (2014). Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Experimental Cell Research, 328(1), 228-237. DOI Scopus8 WoS10 Europe PMC5
  2014	Nik, S., Croft, K., Mori, T., & Lardelli, M. (2014). The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish, 11(3), 248-254. DOI Scopus9 WoS8 Europe PMC7
  2014	Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Nik, S., . . . Lardelli, M. (2014). Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human Molecular Genetics, 23(3), 602-617. DOI Scopus24 WoS23 Europe PMC15
  2014	Moussavi Nik, S., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., & Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(1), 767-775. DOI Scopus11 Europe PMC5
  2014	Klarić, T., Lardelli, M., Key, B., Koblar, S., & Lewis, M. (2014). Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain. Frontiers in Neuroanatomy, 8(DEC), 148-1-148-13. DOI Scopus8 WoS9 Europe PMC6
  2013	Wilson, L., & Lardelli, M. (2013). The development of an in vivo γ-secretase assay using zebrafish embryos. Journal of Alzheimer's Disease, 36(3), 521-534. DOI Scopus7 WoS7 Europe PMC2
  2013	Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., . . . Verdile, G. (2013). The Guinea Pig as a model for sporadic Alzheimer's Disease (AD): the impact of cholesterol intake on expression of AD-related genes. PLoS One, 8(6), 1-12. DOI Scopus20 WoS18 Europe PMC12
  2012	Avdesh, A., Chen, M., Martin-Iverson, M., Mondal, A., Ong, D., Rainey-Smith, S., . . . Martins, R. (2012). Regular care and maintenance of a Zebrafish (Danio rerio) laboratory: an introduction. Journal of Visualized Experiments, (69), 1-8. DOI Scopus59 WoS49 Europe PMC22
  2012	Newman, M., Nornes, S., Martins, R., & Lardelli, M. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19. DOI Scopus1 WoS2 Europe PMC1
  2012	Moussavi Nik, S., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I., & Lardelli, M. (2012). The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease, 28(3), 515-530. DOI Scopus24 WoS16 Europe PMC18
  2012	Avdesh, A., Martin-Iverson, M., Mondal, A., Chen, M., Askraba, S., Newman, M., . . . Martins, R. (2012). Evaluation of color preference in zebrafish for learning and memory. Journal of Alzheimer's Disease, 28(2), 459-469. DOI Scopus41 WoS39 Europe PMC19
  2012	Chen, M., Tegg, M., Avdesh, A., Mondal, A., Lardelli, M., Verdile, G., & Martins, R. (2012). Analysis of insulin-degrading enzyme (IDE) expression and function in zebrafish embryos. Alzheimer's & Dementia, 8(4), P674. DOI
  2011	Sugano, Y., & Lardelli, M. (2011). Identification and expression analysis of the zebrafish orthologue of Klotho. Development Genes and Evolution, 221(3), 179-186. DOI Scopus8 WoS7 Europe PMC5
  2011	Wells, S., Nornes, S., & Lardelli, M. (2011). Transgenic zebrafish recapitulating tbx16 gene early developmental expression. PLoS One, 6(6), e21559-1-e21559-6. DOI Scopus5 WoS5 Europe PMC5
  2011	Moussavi Nik, S., Newman, M., & Lardelli, M. (2011). The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental Cell Research, 317(11), 1503-1512. DOI Scopus17 WoS16 Europe PMC14
  2011	Newman, M., Verdile, G., Martins, R., & Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1812(3), 346-352. DOI Scopus39 WoS30 Europe PMC21
  2010	Newman, M., & Lardelli, M. (2010). A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos. BMC Research Notes, 3(1), 282-286. DOI Scopus6 Europe PMC5
  2010	Wells, S., Conran, J., Tamme, R., Gaudin, A., Webb, J., & Lardelli, M. (2010). Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord. Experimental Cell Research, 316(19), 3292-3303. DOI
  2010	Newman, M., Wilson, L., Camp-Dotlic, E., Verdile, G., Martins, R., & Lardelli, M. (2010). A zebrafish melanophore model of amyloidβ toxicity. Zebrafish, 7(2), 155-159. DOI Scopus15 WoS15 Europe PMC10
  2010	Aleklett, K., Hook, M., Jakobsson, K., Lardelli, M., Snowden, S., & Soderbergh, B. (2010). The peak of the oil age - Analyzing the world oil production reference scenario in world energy outlook 2008. Energy Policy, 38(3), 1398-1414. DOI Scopus207 WoS165
  2009	Chen, M., Martins, R., & Lardelli, M. (2009). Complex splicing and neural expression of duplicated Tau genes in zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317. DOI Scopus30 WoS27 Europe PMC16
  2009	Henshall, T., Tucker, B., Lumsden, A., Nornes, S., Lardelli, M., & Richards, R. (2009). Selective neuronal requirement for Huntingtin in the developing zebrafish. Human Molecular Genetics, 18(24), 4830-4842. DOI Scopus29 WoS29 Europe PMC22
  2009	Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., & Lardelli, M. (2009). Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 316(16), 2791-2801. DOI Scopus27 WoS26 Europe PMC15
  2009	Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's Disease pathogenesis. Journal of Alzheimer's Disease, 16(1), 133-147. DOI Scopus23 WoS23 Europe PMC14
  2009	Nornes, S., Tucker, B., & Lardelli, M. (2009). Zebrafish aplnra functions in epiboly. BMC Research Notes, 2(1), 1-6. DOI Scopus6 Europe PMC5
  2009	Lardelli, M. (2009). Mining the data on coal. Science, 324(5929), 880-881. DOI Scopus2 WoS1
  2009	Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Erratum: Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis (Journal of Alzheimer's Disease (2009) 16:1 (133-147)). Journal of Alzheimer's Disease, 18(4), 993. DOI
  2008	Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., . . . Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412. DOI Scopus30 WoS30 Europe PMC17
  2007	Khut, P., Tucker, B., Lardelli, M., & Wood, S. (2007). Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, Usp9. Zebrafish, 4(2), 95-101. DOI Scopus7 WoS6 Europe PMC6
  2007	Tucker, B., & Lardelli, M. (2007). A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. Zebrafish, 4(2), 113-116. DOI Scopus62 WoS61 Europe PMC37
  2007	Belle, L., Wadham, C., Crocker, L., Lardelli, M., & Khew-Goodall, Y. (2007). The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development. Journal of Cell Biology, 178(7), 1223-1235. DOI Scopus63 WoS59 Europe PMC42
  2007	Lumsden, A., Henshall, T., Dayan, S., Lardelli, M., & Richards, R. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human Molecular Genetics, 16(16), 1905-1920. DOI Scopus111 WoS107 Europe PMC76
  2007	Newman, M., Musgrave, I., & Lardelli, M. (2007). Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1772(3), 285-297. DOI Scopus104 WoS92 Europe PMC54
  2007	Lardelli, M. (2007). Scientists need to confront economists about peak oil. Nature, 446(7133), 257. DOI Scopus3 WoS3 Europe PMC1
  2007	Tucker, B., Hepperle, C., Kortschak, R., Rainbird, B., Wells, S., Oates, A., & Lardelli, M. (2007). Zebrafish Angiotensin II receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene Expression Patterns, 7(3), 258-265. DOI WoS22 Europe PMC19
  2007	Newman, M., Musgrave, I., & Lardelli, M. (2007). Corrigendum to "Alzheimer disease: Amyloidogenesis, the presenilins and animal models" [Biochim. Biophys. Acta 1772 (2007) 285-297] (DOI:10.1016/j.bbadis.2006.12.001). Biochimica et Biophysica Acta - Molecular Basis of Disease, 1772(9), 1118. DOI
  2006	Tucker, B., Richards, R., & Lardelli, M. (2006). Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Human Molecular Genetics, 15(23), 3446-3458. DOI Scopus89 WoS85 Europe PMC69
  2004	Tucker, B., Richards, R., & Lardelli, M. (2004). Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships. Development Genes and Evolution, 214(11), 567-574. DOI Scopus28 WoS25 Europe PMC18
  2004	Scholpp, S., Groth, C., Lohs, C., Lardelli, M., & Brand, M. (2004). Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development Genes and Evolution, 214(6), 285-295. DOI Scopus51 WoS44 Europe PMC41
  2003	Lardelli, M. (2003). The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Development Genes and Evolution, 213(10), 519-522. DOI Scopus15 WoS16 Europe PMC15
  2003	Camp-Dotlic, E., Badhwar, P., Mann, G., & Lardelli, M. (2003). Expression analysis of a Tyrosinase promoter sequence in zebrafish. Pigment Cell Research, 16(2), 117-126. DOI Scopus12 WoS13 Europe PMC7
  2003	Camp-Dotlic, E., Hope, R., Kortschak, R., Cox, T., & Lardelli, M. (2003). Expression of three spalt (sal) gene homologues in zebrafish embryos. Development Genes and Evolution, 213(1), 35-43. DOI Scopus20 WoS19 Europe PMC17
  2003	Nornes, S., Groth, C., Camp-Dotlic, E., Ey, P., & Lardelli, M. (2003). Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Experimental Cell Research, 289(1), 124-132. DOI Scopus39 WoS35 Europe PMC24
  2003	Lardelli, M. (2003). Something fishy in 21st century genomics. Todays Life Science, 15, 20-23.
  2002	Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail. BMC Developmental Biology, 2(9), www 1-www 13. DOI
  2002	Groth, C., Nornes, S., Mc Carty, R., Tamme, R., & Lardelli, M. (2002). Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Development Genes and Evolution, 212(10), 486-490. DOI Scopus42 WoS40 Europe PMC24
  2002	Groth, C., & Lardelli, M. (2002). The structure and function of vertebrate fibroblast growth factor receptor 1. International Journal of Developmental Biology, 46(4 Special Issue SI), 393-400. Scopus64 WoS64 Europe PMC45
  2002	Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail.. BMC developmental biology [electronic resource], 2(1), 9. DOI Scopus8 Europe PMC11
  2002	Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermaldeterminant spadetail. BMC Developmental Biology, 2, 1-13. DOI Scopus11
  2002	Kortschak, R., Tamme, R., & Lardelli, M. (2002). Erratum: Evolutionary analysis of vertebrate Notch genes (Development Genes and Evolution (2001) vol. 211 (350-354)). Development Genes and Evolution, 212(3), 158. DOI
  2001	Holland, L., Rached, L., Tamme, R., Holland, N., Kortschak, D., Inoko, H., . . . Lardelli, M. (2001). Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates (vol 232, pg 493, 2001). DEVELOPMENTAL BIOLOGY, 233(1), 238. DOI
  2001	Jonsson, J., Xiang, Z., Pettersson, M., Lardelli, M., & Nilsson, G. (2001). Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. European Journal of Immunology, 31(11), 3240-3247. DOI Scopus40 WoS39 Europe PMC27
  2001	Holland, L., Rached, L., Tamme, R., Holland, N., Inoko, H., Kortschak, R., . . . Lardelli, M. (2001). Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Developmental Biology, 232(2), 493-507. DOI Scopus48 WoS46 Europe PMC32
  2001	Camp-Dotlic, E., & Lardelli, M. (2001). Tyrosinase gene expression in zebrafish embryos. Development Genes and Evolution, 211(3), 150-153. DOI Scopus46 WoS43 Europe PMC31
  2001	Kortschak, R., Tamme, R., & Lardelli, M. (2001). Evolutionary analysis of vertebrate Notch genes. Development Genes and Evolution, 211(7), 350-354. DOI Scopus27 WoS29 Europe PMC22
  2001	Tamme, R., Mills, K., Rainbird, B., Nornes, S., & Lardelli, M. (2001). Simple, directional cDNA cloning for in situ transcript hybridization screens. Biotechniques, 31(4), 938-946. DOI Scopus6 WoS5 Europe PMC5
  2000	Tamme, R., Camp-Dotlic, E., Kortschak, R., & Lardelli, M. (2000). Non-specific, nested suppression PCR method for isolation of unknown flanking DNA. Biotechniques, 28(5), 895-902. DOI Scopus9 WoS8 Europe PMC6
  1997	Westin, J., & Lardelli, M. (1997). Three novel Notch genes in zebrafish: Implications for vertebrate Notch gene evolution and function. Development Genes and Evolution, 207(1), 51-63. DOI Scopus112 WoS110 Europe PMC57
  1997	Zhang, H., Lardelli, M., & Ekblom, P. (1997). Sequence of zebrafish fibulin-1 and its expression in developing heart and other embryonic organs. Development Genes and Evolution, 207(5), 340-351. DOI Scopus13 WoS12 Europe PMC5
  1997	Lardelli, M. (1997). Generation and PCR screening of bacteriophage gamma sublibraries enriched for rare clones (the "sublibrary method").. Methods in molecular biology (Clifton, N.J.), 67, 345-355. DOI Scopus3 Europe PMC1
  1996	Lardelli, M., Williams, R., Mitsiadis, T., & Lendahl, U. (1996). Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mechanisms of Development, 59(2), 177-190. DOI Scopus82 WoS82 Europe PMC59
  1995	Dahlstrand, J., Lardelli, M., & Lendahl, U. (1995). Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Developmental Brain Research, 84(1), 109-129. DOI Scopus401 WoS381 Europe PMC294
  1995	Mitsiadis, T., Lardelli, M., Lendahl, U., & Thesleff, I. (1995). Expression of Notch 1, 2, and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. Journal of Cell Biology, 130(2), 407-418. DOI Scopus135 WoS138 Europe PMC97
  1995	Williams, R., Lendahl, U., & Lardelli, M. (1995). Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mechanisms of Development, 53(3), 357-368. DOI Scopus135 WoS141 Europe PMC92
  1995	Lardelli, M. (1995). Residents’ rights. Nature, 378(6555), 330. DOI
  1995	Lardelli, M., Williams, R., & Lendahl, U. (1995). Notch-related genes in animal development. International Journal of Developmental Biology, 39(5), 769-780. Scopus48 WoS49 Europe PMC30
  1995	Lardelli, M. (1995). Discriminatory frontier policy. Nature, 376(6535), 12. DOI
  1994	Lardelli, M., Dahlstrand, J., & Lendahl, U. (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mechanisms of Development, 46(2), 123-136. DOI Scopus252 WoS270 Europe PMC171
  1994	Larsson, C., Lardelli, M., White, I., & Lendahl, U. (1994). The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. Genomics, 24(2), 253-258. DOI Scopus76 WoS84 Europe PMC51
  1994	Barlow, C., Meister, B., Lardelli, M., Lendahl, U., & Vennström, B. (1994). Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO Journal, 13(18), 4241-4250. DOI Scopus65 WoS69 Europe PMC38
  1994	Lardelli, M., & Lendahl, U. (1994). Generating bacteriophage λ sublibraries enriched for rare clones. BioTechniques, 16(3), 420-422. Scopus10 WoS10 Europe PMC7
  1993	Lardelli, M., & Ish-Horowicz, D. (1993). Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. Development, 118(1), 255-266. Scopus11 WoS11 Europe PMC8
  1993	Lardelli, M., & Lendahl, U. (1993). Motch A and Motch B — Two mouse Notch homologues coexpressed in a wide variety of tissues. Experimental Cell Research, 204(2), 364-372. DOI Scopus119 WoS132 Europe PMC67
  1989	Rushlow, C., Hogan, A., Pinchin, S., Howe, K., Lardelli, M., & Ish-Horowicz, D. (1989). The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.. The EMBO journal, 8(10), 3095-3103. DOI Scopus161 WoS231 Europe PMC130
  1989	Johnson, M., Misra, R., Lardelli, M., Messina, M., Ephraums, C., Reeves, P., . . . Holmes, I. (1989). Synthesis in Escherichia coli of the major glycoprotein of human rotavirus: analysis of the antigenic regions. Gene, 84(1), 73-81. DOI Scopus8 WoS9 Europe PMC9

• Books

  Year	Citation
  2013	Aleklett, K., Lardelli, M., & Qvennerstedt, O. (2013). Peeking at peak oil (Vol. 9781461434245). Springer. DOI Scopus44

• Book Chapters

  Year	Citation
  2017	Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G., & Lardelli, M. (2017). Animal models of Alzheimer's disease. In M. Conn (Ed.), Animal Models for the Study of Human Disease (2 ed., pp. 1031-1085). United States: Academic Press. DOI Scopus3
  2013	Chen, M., Kretzschmar, D., Verdile, G., & Lardelli, M. (2013). Models of Alzheimer's disease. In P. Conn (Ed.), Animal Models for the Study of Human Disease (1 ed., pp. 595-633). United Kingdom: Elsevier. DOI Scopus1
  2002	Lardelli, M. (2002). Generation and PCR screening of bacteriophage lambda sublibraries enriched for rare clones (the "sublibrary method"). In PCR Cloning Protocols Second Edition, Ch 41 (Vol. 192, 2 ed., pp. 391-399). Totowa, N.J: Humana Press. DOI Scopus1 Europe PMC1
  2002	Lardelli, M. (2002). Nonspecific, nested suppression PCR method for isolation of unknown flanking DNA ("Cold-start method"). In PCR Cloning Protocols Second Edition, Ch 25 (Vol. 192, pp. 285-292). Totowa, New Jersey: Humana Press. DOI Scopus1

• Conference Papers

  Year	Citation
  2015	Lardelli, M., Ebrahimie, E., Newman, M., Nik, S., & Hoek, M. (2015). Transcriptome analyses using human and zebrafish brain data reveal hypoxia as an important element in Alzheimer's disease. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 324). Cairns, AUSTRALIA: WILEY-BLACKWELL.
  2006	Henshall, T., Lumsden, A., Lardelli, M., & Richards, R. (2006). A critical role for huntingtin in neural development. In INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE Vol. 24 (pp. 511). Banff, CANADA: PERGAMON-ELSEVIER SCIENCE LTD. DOI

• Conference Items

  Year	Citation
  2012	Moussavi Nik, S., Verdile, G., Sharman, M., Chen, M., Ong, D., Wijaya, L., . . . Martins, R. (2012). The impact of cholesterol intake on expression of Alzheimer's disease–related genes in the guinea pig brain. Poster session presented at the meeting of Alzheimer's and Dementia. Vancouver, British Columbia: Elsevier. DOI

• Theses

  Year	Citation
  1991	Lardelli, M. (1991). Regulation and function of the pair-rule gene hairy in Drosophila melanogaster..

Michael Lardelli teaches at all levels of genetics but specialising in developmental genetics, genetic manipulation of model organisms, and the genetics of Alzheimers' disease.

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• Current Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2018	Principal Supervisor	Transcriptome analysis of genetic zebrafish models of familial Alzheimer's disease and human sporadic Alzheimer's disease	Doctor of Philosophy	Doctorate	Full Time	Miss Nhi Hin
  2017	Principal Supervisor	Investigating Alzheimers Disease using Zebrafish Genetic Models	Doctor of Philosophy	Doctorate	Full Time	Mr Yang Dong
  2017	Principal Supervisor	Investigating the role of protein truncating mutations in Sorl1 & Psen2	Doctor of Philosophy	Doctorate	Full Time	Miss Karissa Barthelson
  2014	Principal Supervisor	Investigating the Molecular Pathology of Alzheimer's Disease using the Zebrafish Model System	Doctor of Philosophy	Doctorate	Full Time	Tanya Jayne

• Past Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2014 - 2018	Principal Supervisor	Identifying the pathological changes caused by familial Alzheimer’s disease-like mutations in zebrafish psen2	Doctor of Philosophy	Doctorate	Full Time	Ms Haowei Jiang
  2012 - 2016	Co-Supervisor	An Investigation of the Role of CreB Deubiquitinating Enzyme in the Regulation of Carbon Metabolism in Aspergillus nidulans	Doctor of Philosophy	Doctorate	Part Time	Mr Md Ashiqul Alam
  2011 - 2015	Principal Supervisor	Analysing the Biological Function of PS2V: An Aberrant Splicing Phenomenon or Evolutionarily Conserved Mechanism in Alzheimer's Disease	Doctor of Philosophy	Doctorate	Full Time	Dr Seyyed Hani Moussavi Nik
  2011 - 2015	Principal Supervisor	ANALYSING THE ROLE OF AUTOPHAGY IN ALZHEIMER'S DISEASE PATHOGENESIS USING THE ZEBRAFISH MODEL SYSTEM	Doctor of Philosophy	Doctorate	Full Time	Mr Swamynathan Ganesan
  2011 - 2015	Principal Supervisor	Analysis of the Subcellular Localization of Proteins Implicated in Alzheimer's Disease	Doctor of Philosophy	Doctorate	Full Time	Miss Anne Hwee Ling Lim
  2010 - 2011	Principal Supervisor	Characterization of the zebrafish Orthologue of Klotho	Master of Science	Master	Full Time	Mr Yuya Sugano
  2009 - 2011	Principal Supervisor	Molecular Responses to Low Oxygen Levels/Oxidative Stress in Zebrafish	Master of Science	Master	Full Time	Dr Seyyed Hani Moussavi Nik
  2009 - 2012	Co-Supervisor	Function and Evolution of the piRNA Pathway in the Amniote Gonad and Human Ovarian Cancer	Doctor of Philosophy	Doctorate	Full Time	Miss Shu Ly Lim
  2008 - 2011	Co-Supervisor	From Model Organism to Industrial Workhorse	Doctor of Philosophy	Doctorate	Part Time	Mr Jai Denton
  2008 - 2013	Principal Supervisor	The analysis of Presenilin processing and activity with a focus on its implications for Alzheimer's disease pathogenesis using Danio Rerio as a model organism	Doctor of Philosophy	Doctorate	Full Time	Mr Lachlan James Wilson
  2008 - 2009	Principal Supervisor	Identification and Analysis of the Two Tau Paralogues in Zebrafish	Master of Science	Master	Full Time	Miss Mengqi Chen
  2006 - 2010	Co-Supervisor	Investigation of RNA-Mediated Pathogenic Pathways in a Drosophila Model of Expanded Repeat Disease	Doctor of Philosophy	Doctorate	Full Time	Dr Clare van Eyk
  2006 - 2011	Co-Supervisor	Tyrosine Phosphatase Pez: A Novel Regulator of TGFß Signalling, Epithelial-Mesenchymal Transition and Protein Secretion in Development and Cancer	Doctor of Philosophy	Doctorate	Full Time	Mrs Leila Belle
  2005 - 2008	Principal Supervisor	Analysis of Genes Implicated in Alzheimer's Disease Pathogenesis Using Danio Rerio as a Model Organism	Doctor of Philosophy	Doctorate	Full Time	Ms Morgan Newman
  2004 - 2010	Co-Supervisor	Huntingtin Function During Zebrafish (Danio rerio) Development	Doctor of Philosophy	Doctorate	Full Time	Miss Tanya Henshall
  2003 - 2008	Co-Supervisor	The Genetic and Biochemical Analysis of Drosophila Wwox Protein Function	Doctor of Philosophy	Doctorate	Full Time	Mr Alexander Colella
  2003 - 2008	Principal Supervisor	Zebrafish as a Model of Genetic Disease	Doctor of Philosophy	Doctorate	Full Time	Dr Ben Tucker
  2002 - 2007	Co-Supervisor	Investigating the Role of Huntingtin in Development and Disease using the Zebrafish Model Organism	Doctor of Philosophy	Doctorate	Full Time	Ms Amanda Lumsden
  2001 - 2011	Principal Supervisor	An Investigation into the Development and Patterning of Dorsal Longitudinal Ascending Interneurons in Danio Rerio	Doctor of Philosophy	Doctorate	Full Time	Dr Simon Wells
  2000 - 2004	Principal Supervisor	Alzheimer's disease genes in zebrafish (Danio rerio)	Doctor of Philosophy	Doctorate	Full Time	Mr Casper Groth
  1999 - 2003	Principal Supervisor	Development of a Transgenic Strategy for Facilitated Modifier Mutation Screening in Zebrafish	Doctor of Philosophy	Doctorate	Part Time	Dr Esther Camp-Dotlic
  1998 - 2004	Principal Supervisor	Development and application of novel cloning strategies for analysis of genes controlling embryo development	Doctor of Philosophy	Doctorate	Full Time	Mr Richard Tamme

• Position: Associate Professor
• Phone: 83133212
• Email: michael.lardelli@adelaide.edu.au
• Fax: 8313 7534
• Campus: North Terrace
• Building: Molecular Life Sciences, floor 1
• Room: 1 25
• Org Unit: Molecular and Biomedical Science