Michael Lardelli

Research Interests

Animal Developmental Cell Metabolism Cellular Nervous System Central Nervous System Developmental Genetics Genetically Modified Animals Genetics Genomics Medical Genetics Molecular Evolution Neurogenetics Transgenesis

APrf Michael Lardelli

Associate Professor

School of Biological Sciences

College of Science

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

We exploit advanced 'omics technologies (e.g. trancriptomics, proteomics, metabolomics) to investigate the mechanisms underlying Alzheimer's disease using zebrafish models of mutations causing the disease. Our main focus is the gene PRESENILIN 1 in which most such mutations occur.

Recently our research has expanded into investigation of a form of childhood dementia, Sanfilippo syndrome, as we examine commonalities between it and Alzheimer's disease.

Research projects in our laboratory commonly combine molecular biology with zebrafish genome manipulation and behavioural analysis. Bioinformatics analysis is conducted in collaboration with Karissa Barthelson.

In 2023 Michael Lardelli has taken over responsibility for the University of Adelaide's Drosophila melanogaster ("fruit fly") facility. Consequently, research into Alzheimer's disease and Sanfilippo syndrome has also begun using this organism.

Date Position Institution name
2015 - ongoing Associate Professor in Genetics University of Adelaide

Language Competency
English Can read, write, speak, understand spoken and peer review
Swedish Can read, write, speak and understand spoken

Date Institution name Country Title
1987 - 1991 Council for National Academic Awards United Kingdom Ph.D.
1981 - 1984 University of Sydney Australia B.Sc. (Hons)

Date Title Institution Country
1994 - 1995 ESF Postdoctoral Fellowship Uppsala University Sweden
1991 - 1994 EMBO Long Term Postodoctoral Fellowship Karolinska Institute Sweden

Year Citation
2025 Barthelson, K., Protzman, R. A., Snel, M. F., Hemsley, K., & Lardelli, M. (2025). Multi-omics analyses of early-onset familial Alzheimer's disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.. Biochim Biophys Acta Mol Basis Dis, 1871(3), 167651.
DOI Scopus1 WoS1
2025 Hillman, C., Fontana, B. D., Amstislavskaya, T. G., Gorbunova, M. A., Altenhofen, S., Barthelson, K., . . . Parker, M. O. (2025). Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study.. Lab Anim (NY), 54(6), 156-164.
DOI Scopus8 WoS6 Europe PMC5
2024 Baer, L., Barthelson, K., Postlethwait, J. H., Adelson, D. L., Pederson, S. M., & Lardelli, M. (2024). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis.. PLoS Comput Biol, 20(2), e1011868.
DOI WoS1 Europe PMC1
2024 Hillman, C., Fontana, B. D., Amstislavskaya, T. G., Gorbunova, M. A., Altenhofen, S., Barthelson, K., . . . Parker, M. O. (2024). Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.. Res Sq.
DOI
2023 Baer, L., Barthelson, K., Postlethwait, J., Adelson, D., Pederson, S., & Lardelli, M. (2023). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. bioRxiv.
DOI
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer’s Disease Genetics.
DOI
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer’s Disease Genetics.
DOI
2023 Ha, T. T., Burgess, R., Newman, M., Moey, C., Mandelstam, S. A., Gardner, A. E., . . . Corbett, M. A. (2023). Aicardi Syndrome Is a Genetically Heterogeneous Disorder. Genes, 14(8), 1565.
DOI Scopus4 WoS2 Europe PMC3
2023 Allen, A. G., Barthelson, K., & Lardelli, M. (2023). pHAPE: a plasmid for production of DNA size marker ladders for gel electrophoresis.. Biol Methods Protoc, 8(1), bpad015.
DOI Scopus1 WoS1 Europe PMC1
2023 Gerken, E., Ahmad, S., Rattan, L., Hemsley, K., Hemsley, K., Suo, S., . . . Lardelli, M. (2023). Zebrafish models of Mucopolysaccharidosis types IIIA, B, & C show hyperactivity and changes in oligodendrocyte state.
DOI Europe PMC2
2023 Lardelli, M. (2023). An Alternative View of Familial Alzheimer's Disease Genetics.. Journal of Alzheimer's disease : JAD, 96(1), 1-27.
DOI Scopus11 WoS11 Europe PMC9
2023 Lardelli, M., Baer, L., Hin, N., Allen, A., Pederson, S. M., & Barthelson, K. (2023). The Use of Zebrafish in Transcriptome Analysis of the Early Effects of Mutations Causing Early Onset Familial Alzheimer's Disease and Other Inherited Neurodegenerative Conditions.. Journal of Alzheimer's disease : JAD, 99(s2), 1-15.
DOI Scopus6 WoS4 Europe PMC3
2023 Barthelson, K., Protzman, R., Protzman, R., Snel, M., Snel, M., Hemsley, K., & Lardelli, M. (2023). Multi-omics analyses of early-onset familial Alzheimer’s disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.
DOI
2022 Barthelson, K., Newman, M., & Lardelli, M. (2022). Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. Disease Models and Mechanisms, 15(1), 1-14.
DOI Scopus11 WoS7 Europe PMC6
2022 Allen, A., Barthelson, K., & Lardelli, M. (2022). pHAPE: a plasmid for production of DNA size marker ladders for gel electrophoresis.
DOI
2021 Coulson, M., Searle, I., Richards, R., Tucker, M. R., Bakaj, N., Bertozzi, T., . . . Lardelli, M. (2021). Multiple learning and administrative advantages when an advanced course in genetics adopted a “flipped-classroom” format with continuous, online assessment.
DOI
2021 Jayne, T., Newman, M., Baer, L., & Lardelli, M. (2021). The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish. BMC Research Notes, 14(1), 1-5.
DOI
2021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Differential effects of loss of<i>park7</i>activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease.
DOI
2021 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2021). In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. Journal of Alzheimer's Disease Reports, 5(1), 395-404.
DOI Scopus10 WoS9 Europe PMC10
2021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). PRESENILIN 1 mutations causing early-onset familial alzheimer's disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction. Journal of Alzheimers Disease, 82(1), 327-347.
DOI Scopus9 WoS9 Europe PMC10
2021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.. Mol Brain, 14(1), 83.
DOI Scopus9 WoS9 Europe PMC8
2021 Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., . . . Lardelli, M. (2021). Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in Genetics, 12, 1-11.
DOI Scopus4 WoS6 Europe PMC7
2021 Hin, N., Newman, M., Pederson, S., & Lardelli, M. (2021). Iron responsive element-mediated responses to iron dyshomeostasis in Alzheimer's disease. Journal of Alzheimers Disease, 84(4), 1-34.
DOI Scopus17 WoS18 Europe PMC28
2021 Hin, N., Newman, M., Pederson, S., & Lardelli, M. (2021). Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer's disease. Journal of Alzheimer's Disease, 84(4), 1597-1630.
DOI Europe PMC3
2021 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2021). Brain transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial alzheimer's disease indicates early effects on mitochondrial and ribosome function. Journal of Alzheimer's Disease, 79(3), 1105-1119.
DOI Scopus9 WoS9 Europe PMC11
2021 Barthelson, K., Newman, M., Nowell, C. J., & Lardelli, M. (2021). No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene. Molecular Brain, 14(1), 22-1-22-4.
DOI Scopus2 WoS1 Europe PMC1
2021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). <i>PRESENILIN 1</i>mutations causing early-onset familial Alzheimer’s disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction.
DOI Europe PMC1
2021 Barthelson, K., Newman, M., & Lardelli, M. (2021). Comparative analysis of Alzheimer’s disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress.
DOI
2021 Dong, Y., Newman, M., Pederson, S. M., Barthelson, K., Hin, N., & Lardelli, M. (2021). Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics, 22(1), 211-1-211-16.
DOI Scopus16 WoS15 Europe PMC15
2021 Moussavi Nik, S. H., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., . . . Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 transcript to Alzheimer's disease and neurodegeneration.. Journal of Alzheimer's Disease, 80(4), 1-11.
DOI Scopus4 WoS4 Europe PMC5
2020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease. biorxiv.
DOI
2020 Jiang, H., Pederson, S. M., Newman, M., Dong, Y., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene<i>psen2</i>.
DOI
2020 Newman, M., Moussavi Nik, S. H., Sutherland, G. T., Hin, N., Kim, W. S., Halliday, G. M., . . . Lardelli, M. (2020). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1. Human Molecular Genetics, 29(14), 2379-2394.
DOI Scopus14 WoS11 Europe PMC11
2020 Barthelson, K., Newman, M., & Lardelli, M. (2020). Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease. Journal of Alzheimer’s Disease Reports, 4(1), 123-140.
DOI Scopus29 WoS27 Europe PMC31
2020 Jiang, H., Pederson, S. M., Newman, M., Dong, Y., Barthelson, K., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2. PLoS One, 15(7), e0232559-1-e0232559-25.
DOI Scopus9 WoS8 Europe PMC9
2020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer's disease.. Molecular brain, 13(1), 142.
DOI Scopus27 WoS27 Europe PMC28
2020 Barthelson, K., Pederson, S., Newman, M., & Lardelli, M. (2020). Transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains. biorxiv.
DOI Europe PMC1
2020 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2020). Frameshift and frame-preserving mutations in zebrafish presenilin 2 affect different cellular functions in young adult brains.
DOI Europe PMC2
2020 Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Moussavi Nik, S. H., . . . Lardelli, M. (2020). Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. PloS one, 15(1), e0227258.
DOI Scopus27 WoS24 Europe PMC30
2019 Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production.
DOI Europe PMC1
2019 Newman, M., Nik, H. M., Sutherland, G., Hin, N., Kim, W., Halliday, G., . . . Lardelli, M. (2019). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer’s disease-like mutation of Presenilin 1.
DOI Europe PMC1
2019 Newman, M., Hin, N., Pederson, S., & Lardelli, M. (2019). Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular Brain, 12(1), 1-5.
DOI Scopus23 WoS22 Europe PMC28
2019 Braggin, J. E., Bucks, S. A., Course, M. M., Smith, C. L., Sopher, B., Osnis, L., . . . Jayadev, S. (2019). Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology, 6(4), 762-777.
DOI Scopus35 WoS32 Europe PMC32
2018 Lumsden, A., Rogers, J., Majd, S., Newman, M., Sutherland, G., Verdile, G., & Lardelli, M. (2018). Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease. Frontiers in Neuroscience, 12(533), 533-1-533-21.
DOI Scopus39 WoS37 Europe PMC35
2018 Nik, S. H. M., Newman, M., Lumsden, A., Jayne, T., & Lardelli, M. (2018). HMGA1 zebrafish co-orthologue hmga1b can modulate p53-dependent cellular responses but is unable to control the alternative splicing of psen1.
DOI
2018 Jiang, H., Newman, M., & Lardelli, M. (2018). The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation. PLoS ONE, 13(10), e0206155-1-e0206155-20.
DOI Scopus23 WoS19 Europe PMC17
2018 Jiang, H., Jayadev, S., Lardelli, M., & Newman, M. (2018). A Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1. Journal of Alzheimer's Disease, 66(4), 1323-1339.
DOI Scopus21 WoS20 Europe PMC19
2018 Ratnayake, D., Newman, M., & Lardelli, M. (2018). Degenerate codon mixing for PCR-based manipulation of highly repetitive sequences. BMC Research Notes, 11(1), 202-1-202-7.
DOI Scopus1 Europe PMC1
2018 Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Zhou, X., . . . Lardelli, M. (2018). Accelerated brain aging towards transcriptional inversion in a zebrafish model of familial Alzheimer's disease. BioRxiv, OnlinePubl.
DOI Europe PMC1
2017 Newman, M., Halter, L., Lim, A., & Lardelli, M. (2017). Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer’s disease. PLoS ONE, 12(6), e0179859-1-e0179859-17.
DOI Scopus3 WoS3 Europe PMC3
2016 Ebrahimie, E., Moussavi Nik, S., Newman, M., Van Der Hoek, M., & Lardelli, M. (2016). The Zebrafish equivalent of Alzheimer's disease-associated PRESENILIN Isoform PS2V regulates inflammatory and other responses to hypoxic stress. Journal of Alzheimer's Disease, 52(2), 581-608.
DOI Scopus16 WoS13 Europe PMC14
2016 Jayne, T., Newman, M., Verdile, G., Sutherland, G., Münch, G., Musgrave, I., . . . Lardelli, M. (2016). Evidence for and against a pathogenic role of reduced γ-secretase activity in familial Alzheimer's disease. Journal of Alzheimer's Disease, 52(3), 781-799.
DOI Scopus36 WoS34 Europe PMC39
2016 Richards, R., Robertson, S., O'Keefe, L., Fornarino, D., Scott, A., Lardelli, M., & Baune, B. (2016). The enemy within: innate surveillance-mediated cell death, the common mechanism of neurodegenerative disease. Frontiers in Neuroscience, 10(MAY), 193-1-193-20.
DOI Scopus36 WoS35 Europe PMC30
2015 Moussavi Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., . . . Lardelli, M. (2015). Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678.
DOI Scopus28 WoS25 Europe PMC28
2015 Lim, A., Moussavi Nik, S., Ebrahimie, E., & Lardelli, M. (2015). Analysis of nicastrin gene phylogeny and expression in zebrafish. Development Genes and Evolution, 225(3), 171-178.
DOI Scopus7 WoS7 Europe PMC6
2014 Newman, M., Ebrahimie, E., & Lardelli, M. (2014). Using the zebrafish model for Alzheimer's disease research. Frontiers in Genetics, 5(JUN), 189-1-189-10.
DOI Scopus135 WoS118 Europe PMC87
2014 Ganesan, S., Moussavi Nik, S., Newman, M., & Lardelli, M. (2014). Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Experimental Cell Research, 328(1), 228-237.
DOI Scopus12 WoS13 Europe PMC10
2014 Nik, S., Croft, K., Mori, T., & Lardelli, M. (2014). The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish, 11(3), 248-254.
DOI Scopus13 WoS11 Europe PMC10
2014 Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Nik, S., . . . Lardelli, M. (2014). Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human Molecular Genetics, 23(3), 602-617.
DOI Scopus50 WoS45 Europe PMC43
2014 Moussavi Nik, S. H., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., & Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(1), 767-1-767-9.
DOI Scopus27 Europe PMC13
2014 Klarić, T., Lardelli, M., Key, B., Koblar, S., & Lewis, M. (2014). Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain. Frontiers in Neuroanatomy, 8(DEC), 148-1-148-13.
DOI Scopus20 WoS19 Europe PMC13
2013 Wilson, L., & Lardelli, M. (2013). The development of an in vivo γ-secretase assay using zebrafish embryos. Journal of Alzheimer's Disease, 36(3), 521-534.
DOI Scopus10 WoS9 Europe PMC7
2013 Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., . . . Verdile, G. (2013). The Guinea Pig as a model for sporadic Alzheimer's Disease (AD): the impact of cholesterol intake on expression of AD-related genes. PLoS One, 8(6), 1-12.
DOI Scopus37 WoS36 Europe PMC34
2012 Avdesh, A., Chen, M., Martin-Iverson, M., Mondal, A., Ong, D., Rainey-Smith, S., . . . Martins, R. (2012). Regular care and maintenance of a Zebrafish (Danio rerio) laboratory: an introduction. Journal of Visualized Experiments, (69), 1-8.
DOI Scopus386 WoS342 Europe PMC173
2012 Newman, M., Nornes, S., Martins, R., & Lardelli, M. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19.
DOI Scopus9 WoS7 Europe PMC5
2012 Moussavi Nik, S., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I., & Lardelli, M. (2012). The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease, 28(3), 515-530.
DOI Scopus51 WoS33 Europe PMC43
2012 Avdesh, A., Martin-Iverson, M., Mondal, A., Chen, M., Askraba, S., Newman, M., . . . Martins, R. (2012). Evaluation of color preference in zebrafish for learning and memory. Journal of Alzheimer's Disease, 28(2), 459-469.
DOI Scopus122 WoS110 Europe PMC83
2012 Chen, M., Tegg, M., Avdesh, A., Mondal, A., Lardelli, M., Verdile, G., & Martins, R. (2012). P4‐121: Analysis of insulin‐degrading enzyme (IDE) expression and function in zebrafish embryos. Alzheimer's &amp; Dementia, 8(4S_Part_18).
DOI
2011 Sugano, Y., & Lardelli, M. (2011). Identification and expression analysis of the zebrafish orthologue of Klotho. Development Genes and Evolution, 221(3), 179-186.
DOI Scopus16 WoS14 Europe PMC11
2011 Wells, S., Nornes, S., & Lardelli, M. (2011). Transgenic zebrafish recapitulating tbx16 gene early developmental expression. PLoS One, 6(6), e21559-1-e21559-6.
DOI Scopus14 WoS13 Europe PMC18
2011 Moussavi Nik, S., Newman, M., & Lardelli, M. (2011). The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental Cell Research, 317(11), 1503-1512.
DOI Scopus23 WoS20 Europe PMC20
2011 Newman, M., Verdile, G., Martins, R., & Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1812(3), 346-352.
DOI Scopus72 WoS57 Europe PMC45
2010 Newman, M., & Lardelli, M. (2010). A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos. BMC Research Notes, 3(1), 282-286.
DOI Scopus7 Europe PMC6
2010 Wells, S., Conran, J., Tamme, R., Gaudin, A., Webb, J., & Lardelli, M. (2010). Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord. Experimental Cell Research, 316(19), 3292-3303.
DOI Scopus1 WoS2 Europe PMC6
2010 Newman, M., Wilson, L., Camp-Dotlic, E., Verdile, G., Martins, R., & Lardelli, M. (2010). A zebrafish melanophore model of amyloidβ toxicity. Zebrafish, 7(2), 155-159.
DOI Scopus19 WoS19 Europe PMC14
2010 Aleklett, K., Hook, M., Jakobsson, K., Lardelli, M., Snowden, S., & Soderbergh, B. (2010). The peak of the oil age - Analyzing the world oil production reference scenario in world energy outlook 2008. Energy Policy, 38(3), 1398-1414.
DOI Scopus276 WoS210
2009 Chen, M., Martins, R., & Lardelli, M. (2009). Complex splicing and neural expression of duplicated Tau genes in zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317.
DOI Scopus57 WoS49 Europe PMC40
2009 Henshall, T., Tucker, B., Lumsden, A., Nornes, S., Lardelli, M., & Richards, R. (2009). Selective neuronal requirement for Huntingtin in the developing zebrafish. Human Molecular Genetics, 18(24), 4830-4842.
DOI Scopus43 WoS39 Europe PMC37
2009 Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., & Lardelli, M. (2009). Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 316(16), 2791-2801.
DOI Scopus48 WoS44 Europe PMC34
2009 Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's Disease pathogenesis. Journal of Alzheimer's Disease, 16(1), 133-147.
DOI Scopus29 WoS28 Europe PMC23
2009 Nornes, S., Tucker, B., & Lardelli, M. (2009). Zebrafish aplnra functions in epiboly. BMC Research Notes, 2(1), 1-6.
DOI Scopus7 Europe PMC7
2009 Lardelli, M. (2009). Mining the data on coal. Science, 324(5929), 880-881.
DOI Scopus6 WoS5 Europe PMC1
2009 Newman, M., Tucker, B., Nornes, S., Ward, A., & Lardelli, M. (2009). Erratum: Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis (Journal of Alzheimer's Disease (2009) 16:1 (133-147)). Journal of Alzheimer S Disease, 18(4), 993.
DOI
2008 Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., . . . Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412.
DOI Scopus47 WoS45 Europe PMC37
2007 Khut, P., Tucker, B., Lardelli, M., & Wood, S. (2007). Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, Usp9. Zebrafish, 4(2), 95-101.
DOI Scopus12 WoS11 Europe PMC12
2007 Tucker, B., & Lardelli, M. (2007). A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. Zebrafish, 4(2), 113-116.
DOI Scopus128 WoS126 Europe PMC105
2007 Belle, L., Wadham, C., Crocker, L., Lardelli, M., & Khew-Goodall, Y. (2007). The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development. Journal of Cell Biology, 178(7), 1223-1235.
DOI Scopus75 WoS71 Europe PMC63
2007 Lumsden, A., Henshall, T., Dayan, S., Lardelli, M., & Richards, R. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human Molecular Genetics, 16(16), 1905-1920.
DOI Scopus138 WoS127 Europe PMC109
2007 Newman, M., Musgrave, I., & Lardelli, M. (2007). Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1772(3), 285-297.
DOI Scopus120 WoS108 Europe PMC80
2007 Lardelli, M. (2007). Scientists need to confront economists about peak oil. Nature, 446(7133), 257.
DOI Scopus3 WoS3 Europe PMC1
2007 Tucker, B., Hepperle, C., Kortschak, R., Rainbird, B., Wells, S., Oates, A., & Lardelli, M. (2007). Zebrafish Angiotensin II receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene Expression Patterns, 7(3), 258-265.
DOI Scopus29 WoS29 Europe PMC29
2007 Newman, M., Musgrave, I. F., & Lardelli, M. (2007). Corrigendum to "Alzheimer disease: Amyloidogenesis, the presenilins and animal models" [Biochim. Biophys. Acta 1772 (2007) 285-297] (DOI:10.1016/j.bbadis.2006.12.001). Biochimica Et Biophysica Acta Molecular Basis of Disease, 1772(9), 1118.
DOI Scopus1
2006 Tucker, B., Richards, R., & Lardelli, M. (2006). Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. Human Molecular Genetics, 15(23), 3446-3458.
DOI Scopus108 WoS106 Europe PMC94
2004 Tucker, B., Richards, R., & Lardelli, M. (2004). Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships. Development Genes and Evolution, 214(11), 567-574.
DOI Scopus33 WoS29 Europe PMC26
2004 Scholpp, S., Groth, C., Lohs, C., Lardelli, M., & Brand, M. (2004). Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development Genes and Evolution, 214(6), 285-295.
DOI Scopus62 WoS54 Europe PMC51
2003 Lardelli, M. (2003). The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Development Genes and Evolution, 213(10), 519-522.
DOI Scopus17 WoS17 Europe PMC16
2003 Camp-Dotlic, E., Badhwar, P., Mann, G., & Lardelli, M. (2003). Expression analysis of a Tyrosinase promoter sequence in zebrafish. Pigment Cell Research, 16(2), 117-126.
DOI Scopus14 WoS15 Europe PMC12
2003 Camp-Dotlic, E., Hope, R., Kortschak, R., Cox, T., & Lardelli, M. (2003). Expression of three spalt (sal) gene homologues in zebrafish embryos. Development Genes and Evolution, 213(1), 35-43.
DOI Scopus23 WoS22 Europe PMC22
2003 Nornes, S., Groth, C., Camp-Dotlic, E., Ey, P., & Lardelli, M. (2003). Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Experimental Cell Research, 289(1), 124-132.
DOI Scopus53 WoS47 Europe PMC39
2003 Lardelli, M. (2003). Something fishy in 21st century genomics. Todays Life Science, 15, 20-23.
2002 Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail. BMC Developmental Biology, 2(9), www 1-www 13.
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2002 Groth, C., Nornes, S., Mc Carty, R., Tamme, R., & Lardelli, M. (2002). Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Development Genes and Evolution, 212(10), 486-490.
DOI Scopus64 WoS58 Europe PMC45
2002 Groth, C., & Lardelli, M. (2002). The structure and function of vertebrate fibroblast growth factor receptor 1. International Journal of Developmental Biology, 46(4 Special Issue SI), 393-400.
Scopus76 WoS72 Europe PMC60
2002 Tamme, R., Wells, S., Conran, J. G., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermal determinant spadetail.. BMC developmental biology [electronic resource], 2(1), 9.
DOI Scopus8 Europe PMC14
2002 Tamme, R., Wells, S., Conran, J., & Lardelli, M. (2002). The identity and distribution of neural cells expressing the mesodermaldeterminant spadetail. BMC Developmental Biology, 2, 1-13.
DOI Scopus15
2002 Kortschak, R. D., Tamme, R., & Lardelli, M. (2002). Erratum: Evolutionary analysis of vertebrate Notch genes (Development Genes and Evolution (2001) vol. 211 (350-354)). Development Genes and Evolution, 212(3), 158.
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2001 Holland, L. Z., Rached, L. A., Tamme, R., Holland, N. D., Kortschak, D., Inoko, H., . . . Lardelli, M. (2001). Erratum: Characterization and developmental expression of the amphioxus homolog of Notch (AmnphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates (Developmental Biology (2001) 232:2 (495-507)). Developmental Biology, 233(1), 238.
DOI Scopus1
2001 Jonsson, J., Xiang, Z., Pettersson, M., Lardelli, M., & Nilsson, G. (2001). Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. European Journal of Immunology, 31(11), 3240-3247.
DOI Scopus47 WoS46 Europe PMC43
2001 Holland, L., Rached, L., Tamme, R., Holland, N., Inoko, H., Kortschak, R., . . . Lardelli, M. (2001). Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Developmental Biology, 232(2), 493-507.
DOI Scopus51 WoS48 Europe PMC40
2001 Camp-Dotlic, E., & Lardelli, M. (2001). Tyrosinase gene expression in zebrafish embryos. Development Genes and Evolution, 211(3), 150-153.
DOI Scopus74 WoS69 Europe PMC63
2001 Kortschak, R., Tamme, R., & Lardelli, M. (2001). Evolutionary analysis of vertebrate Notch genes. Development Genes and Evolution, 211(7), 350-354.
DOI Scopus31 WoS31 Europe PMC27
2001 Tamme, R., Mills, K., Rainbird, B., Nornes, S., & Lardelli, M. (2001). Simple, directional cDNA cloning for in situ transcript hybridization screens. Biotechniques, 31(4), 938-946.
DOI Scopus6 WoS5 Europe PMC5
2000 Tamme, R., Camp-Dotlic, E., Kortschak, R., & Lardelli, M. (2000). Non-specific, nested suppression PCR method for isolation of unknown flanking DNA. Biotechniques, 28(5), 895-902.
DOI Scopus10 WoS8 Europe PMC6
1997 Westin, J., & Lardelli, M. (1997). Three novel Notch genes in zebrafish: Implications for vertebrate Notch gene evolution and function. Development Genes and Evolution, 207(1), 51-63.
DOI Scopus124 WoS118 Europe PMC95
1997 Zhang, H. Y., Lardelli, M., & Ekblom, P. (1997). Sequence of zebrafish fibulin-1 and its expression in developing heart and other embryonic organs. Development Genes and Evolution, 207(5), 340-351.
DOI Scopus16 WoS14 Europe PMC9
1997 Lardelli, M. (1997). Generation and PCR screening of bacteriophage gamma sublibraries enriched for rare clones (the "sublibrary method").. Methods in Molecular Biology Clifton N J, 67, 345-355.
DOI Scopus3 Europe PMC1
1996 Lardelli, M., Williams, R., Mitsiadis, T., & Lendahl, U. (1996). Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mechanisms of Development, 59(2), 177-190.
DOI Scopus94 WoS93 Europe PMC84
1995 Dahlstrand, J., Lardelli, M., & Lendahl, U. (1995). Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Developmental Brain Research, 84(1), 109-129.
DOI Scopus468 WoS440 Europe PMC385
1995 Mitsiadis, T. A., Lardelli, M., Lendahl, U., & Thesleff, I. (1995). Expression of Notch 1, 2, and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. Journal of Cell Biology, 130(2), 407-418.
DOI Scopus160 WoS156 Europe PMC134
1995 Williams, R., Lendahl, U., & Lardelli, M. (1995). Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mechanisms of Development, 53(3), 357-368.
DOI Scopus149 WoS149 Europe PMC127
1995 Lardelli, M. (1995). Residents’ rights. Nature, 378(6555), 330.
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1995 Lardelli, M., Williams, R., & Lendahl, U. (1995). Notch-related genes in animal development. International Journal of Developmental Biology, 39(5), 769-780.
Scopus51 WoS50 Europe PMC38
1995 Lardelli, M. (1995). Discriminatory frontier policy. Nature, 376(6535), 12.
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1994 Lardelli, M., Dahlstrand, J., & Lendahl, U. (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mechanisms of Development, 46(2), 123-136.
DOI Scopus275 WoS282 Europe PMC236
1994 Larsson, C., Lardelli, M., White, I., & Lendahl, U. (1994). The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. Genomics, 24(2), 253-258.
DOI Scopus89 WoS94 Europe PMC69
1994 Barlow, C., Meister, B., Lardelli, M., Lendahl, U., & Vennström, B. (1994). Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO Journal, 13(18), 4241-4250.
DOI Scopus77 WoS77 Europe PMC56
1994 Lardelli, M., & Lendahl, U. (1994). Generating bacteriophage λ sublibraries enriched for rare clones. Biotechniques, 16(3), 420-422.
Scopus10 WoS10 Europe PMC8
1993 Lardelli, M., & Ish-Horowicz, D. (1993). Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. Development, 118(1), 255-266.
DOI Scopus12 WoS12 Europe PMC13
1993 Lardelli, M., & Lendahl, U. (1993). Motch A and Motch B — Two mouse Notch homologues coexpressed in a wide variety of tissues. Experimental Cell Research, 204(2), 364-372.
DOI Scopus125 WoS133 Europe PMC98
1989 Rushlow, C. A., Hogan, A., Pinchin, S. M., Howe, K. M., Lardelli, M., & Ish-Horowicz, D. (1989). The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc.. EMBO Journal, 8(10), 3095-3103.
DOI Scopus206 WoS232 Europe PMC185
1989 Johnson, M. A., Misra, R. M., Lardelli, M., Messina, M., Ephraums, C., Reeves, P. R., . . . Holmes, I. H. (1989). Synthesis in Escherichia coli of the major glycoprotein of human rotavirus: analysis of the antigenic regions. Gene, 84(1), 73-81.
DOI Scopus10 WoS9 Europe PMC11

Year Citation
2015 Lardelli, M., Ebrahimie, E., Newman, M., Nik, S. M., & Hoek, M. V. D. (2015). Transcriptome analyses using human and zebrafish brain data reveal hypoxia as an important element in Alzheimer's disease. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 324). Cairns, AUSTRALIA: WILEY-BLACKWELL.
2006 Henshall, T. L., Lumsden, A. L., Lardelli, M. T., & Richards, R. I. (2006). A critical role for huntingtin in neural development. In INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE Vol. 24 (pp. 511). Banff, CANADA: PERGAMON-ELSEVIER SCIENCE LTD.
DOI

Year Citation
1991 Lardelli, M. (1991). Regulation and function of the pair-rule gene hairy in Drosophila melanogaster..

Year Citation
2025 Baer, L., Lardelli, M., & Pederson, S. (2025). <i>tadar</i>: an R/Bioconductor package to reduce eQTL noise in differential expression analysis.
DOI

We receive funding from various sources including the NHMRC and private individuals.

Michael Lardelli teaches at all levels of genetics but specialising in developmental genetics, genetic manipulation of model organisms, and the genetics of Alzheimers' disease.

Date Role Research Topic Program Degree Type Student Load Student Name
2024 Principal Supervisor Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research Doctor of Philosophy Doctorate Full Time Miss Xinya Wang
2024 Principal Supervisor Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research Doctor of Philosophy Doctorate Full Time Miss Xinya Wang
2022 Principal Supervisor Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models Doctor of Philosophy Doctorate Full Time Mr Kaijing Xu
2022 Principal Supervisor Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models Doctor of Philosophy Doctorate Full Time Mr Kaijing Xu

Date Role Research Topic Program Degree Type Student Load Student Name
2025 - 2025 Principal Supervisor Investigating Early Molecular Drivers of Neurodegeneration by Modelling Parkinson's Disease in Zebrafish Master of Philosophy Master Full Time Miss Angel Grace Allen
2021 - 2025 Principal Supervisor Exogenous Ketogenic Therapy to Inhibit the Symptoms Caused by BACE1 in Drosophila and Protect Mitochondria Doctor of Philosophy Doctorate Full Time Mr Hao Huang
2020 - 2025 Principal Supervisor Distinguishing Signal from Artefact: The Detection and Correction of Bias in RNA-sequencing Doctor of Philosophy Doctorate Full Time Mr Lachlan Warren William Baer
2018 - 2020 Principal Supervisor Transcriptome Analysis of Zebrafish Genetic Models to Reveal Early Molecular Drivers of Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Miss Nhi Hin
2017 - 2021 Principal Supervisor Investigating Alzheimer’s disease using zebrafish genetic models Doctor of Philosophy Doctorate Full Time Mr Yang Dong
2017 - 2021 Principal Supervisor Investigating the effects of mutations causative for early-onset familial Alzheimer’s disease using zebrafish as a model organism Doctor of Philosophy Doctorate Full Time Miss Karissa Barthelson
2014 - 2018 Principal Supervisor Identifying the pathological changes caused by familial Alzheimer’s disease-like mutations in zebrafish psen2 Doctor of Philosophy Doctorate Full Time Ms Haowei Jiang
2014 - 2020 Principal Supervisor Investigations of y-secretase substrates Amyloid precursor protein and p75 neurotrophin receptor in zebrafish Doctor of Philosophy Doctorate Full Time Tanya Jayne
2012 - 2016 Co-Supervisor An Investigation of the Role of CreB Deubiquitinating Enzyme in the Regulation of Carbon Metabolism in Aspergillus nidulans Doctor of Philosophy Doctorate Part Time Mr Md Ashiqul Alam
2011 - 2015 Principal Supervisor Analysis of the Subcellular Localization of Proteins Implicated in Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Miss Anne Hwee Ling Lim
2011 - 2015 Principal Supervisor Analysing the Biological Function of PS2V: An Aberrant Splicing Phenomenon or Evolutionarily Conserved Mechanism in Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Mr Seyedhani Moussavinik
2011 - 2015 Principal Supervisor ANALYSING THE ROLE OF AUTOPHAGY IN ALZHEIMER'S DISEASE PATHOGENESIS USING THE ZEBRAFISH MODEL SYSTEM Doctor of Philosophy Doctorate Full Time Mr Swamynathan Ganesan
2010 - 2011 Principal Supervisor Characterization of the zebrafish Orthologue of Klotho Master of Science Master Full Time Mr Yuya Sugano
2009 - 2012 Co-Supervisor Function and Evolution of the piRNA Pathway in the Amniote Gonad and Human Ovarian Cancer Doctor of Philosophy Doctorate Full Time Miss Shu Ly Lim
2009 - 2011 Principal Supervisor Molecular Responses to Low Oxygen Levels/Oxidative Stress in Zebrafish Master of Science Master Full Time Mr Seyedhani Moussavinik
2008 - 2009 Principal Supervisor Identification and Analysis of the Two Tau Paralogues in Zebrafish Master of Science Master Full Time Miss Mengqi Chen
2008 - 2011 Co-Supervisor From Model Organism to Industrial Workhorse Doctor of Philosophy Doctorate Part Time Mr Jai Denton
2008 - 2013 Principal Supervisor The analysis of Presenilin processing and activity with a focus on its implications for Alzheimer's disease pathogenesis using Danio Rerio as a model organism Doctor of Philosophy Doctorate Full Time Mr Lachlan James Wilson
2006 - 2010 Co-Supervisor Investigation of RNA-Mediated Pathogenic Pathways in a Drosophila Model of Expanded Repeat Disease Doctor of Philosophy Doctorate Full Time Dr Clare van Eyk
2006 - 2011 Co-Supervisor Tyrosine Phosphatase Pez: A Novel Regulator of TGFß Signalling, Epithelial-Mesenchymal Transition and Protein Secretion in Development and Cancer Doctor of Philosophy Doctorate Full Time Mrs Leila Belle
2005 - 2008 Principal Supervisor Analysis of Genes Implicated in Alzheimer's Disease Pathogenesis Using Danio Rerio as a Model Organism Doctor of Philosophy Doctorate Full Time Dr Morgan Newman
2004 - 2010 Co-Supervisor Huntingtin Function During Zebrafish (Danio rerio) Development Doctor of Philosophy Doctorate Full Time Miss Tanya Henshall
2003 - 2008 Principal Supervisor Zebrafish as a Model of Genetic Disease Doctor of Philosophy Doctorate Full Time Dr Ben Tucker
2003 - 2008 Co-Supervisor The Genetic and Biochemical Analysis of Drosophila Wwox Protein Function Doctor of Philosophy Doctorate Full Time Mr Alexander Colella
2002 - 2007 Co-Supervisor Investigating the Role of Huntingtin in Development and Disease using the Zebrafish Model Organism Doctor of Philosophy Doctorate Full Time Ms Amanda Lumsden
2001 - 2011 Principal Supervisor An Investigation into the Development and Patterning of Dorsal Longitudinal Ascending Interneurons in Danio Rerio Doctor of Philosophy Doctorate Full Time Dr Simon Wells
2000 - 2004 Principal Supervisor Alzheimer's disease genes in zebrafish (Danio rerio) Doctor of Philosophy Doctorate Full Time Mr Casper Groth
1999 - 2003 Principal Supervisor Development of a Transgenic Strategy for Facilitated Modifier Mutation Screening in Zebrafish Doctor of Philosophy Doctorate Part Time Dr Esther Camp-Dotlic
1998 - 2004 Principal Supervisor Development and application of novel cloning strategies for analysis of genes controlling embryo development Doctor of Philosophy Doctorate Full Time Mr Richard Tamme

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