Hospital Research Foundation Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr van Eyk is a current Hospital Research Foundation Mid-career Fellow at the University of Adelaide where she works with the Adelaide CP and Neurogenetics research groups. Her research focuses on the contribution of genetic and epigenetic variation to cerebral palsy (CP) and other neurodevelopmental disorders using next generation sequencing technologies, including exome sequencing, genome sequencing, targeted gene panel sequencing, RNA sequencing and methylation sequencing, and the functional interpretation of these genetic findings using techniques including animal and cell models. She has co-authored the Adelaide CP group’s pioneering publications demonstrating a significant genetic component to CP (McMichael et al. 2015, Corbett et al. 2018) and collaborative studies which have followed (e.g. Jin et al in press, Nature Genetics). She was lead investigator on the largest transcriptome study in patient-derived cell lines for any neurodevelopmental disorder to date (van Eyk et al. 2018) and the group's proof-of-principle study testing the clinical utility of a targeted gene panel for genetic diagnosis in CP (van Eyk et al. 2019). This work has led to a paradigm shift in understanding of CP aetiology, with a growing acceptance that there is an underlying genetic cause in many cases. Dr van Eyk is a founding member of the International Cerebral Palsy Genomics Consortium and collaborates with many international groups in projects seeking molecular and genetic markers for CP, with the aim of prevention or treatment of CP.
- My Research
- Grants and Funding
- Professional Activities
My research investigates the contribution of genetic and epigenetic variation to cerebral palsy and other neurodevelopmental disorders. This involves both identification of genetic variation using next generation sequencing technologies, and the functional interpretation of these genetic findings using various techniques including animal and cell models.
CURRENT RESEARCH STUDIES:
We are currently recruiting for The Neurodevelopmental Disorder Twin study. In this study, we are inviting monozygotic (identical) twins who are differently affected by one or more neurodevelopmental disorders (including cerebral palsy, autism spectrum disorder, intellectual disability and epilepsy) to participate. We want to understand the causes of the differences in these twin pairs.
We hope that this will help us to predict babies at risk of developing a neurodevelopmental disorder, so that doctors can more closely watch these babies develop and design better therapies or treatments for them. This project has been made possible thanks to funding from the Hospital Research Foundation.
For more information, please see https://health.adelaide.edu.au/neurodevelopmental-disorder-study
Date Position Institution name 2020 - 2022 Hospital Research Foundation Mid-Career Fellow University of Adelaide 2016 - 2019 NHMRC Postdoctoral Research Officer University of Adelaide, Adelaide 2014 - 2016 Cerebral Palsy Alliance Research Foundation Fellow University of Adelaide, Adelaide 2013 - 2014 Postdoctoral Research Officer, ACCPRG University of Adelaide, Adelaide 2010 - 2013 NHMRC Postdoctoral Research Officer University of Adelaide, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2011 Award Postgraduate Academic Achievement Award, School of Molecular and Biomedical Science University of Adelaide Australia — 2011 Award All-round postgraduate achievement award, School of Molecular and Biomedical Science — Australia —
Date Institution name Country Title 2006 - 2010 University of Adelaide Australia PhD 2002 - 2005 University of Adelaide, Adelaide Australia BSc(Hons)
Year Citation 2018 van Eyk, C., Corbett, M., & Maclennan, A. (2018). The emerging genetic landscape of cerebral palsy.. In D. Geschwind, H. Paulson, & C. Klein (Eds.), Neurogenetics (Vol. 147, pp. 331-342).
DOI Scopus5 Europe PMC1
2013 Samaraweera, S., O'Keefe, L., van Eyk, C., Lawlor, K., Humphreys, D., Suter, C., & Richards, R. (2013). Modeling and analysis of repeat RNA toxicity in drosophila. In D. Hatters, & A. Hannan (Eds.), Tandem repeats in genes, proteins, and disease : methods and protocols (Vol. 1017, 1 ed., pp. 173-192). United States: Springer.
DOI Scopus2 Europe PMC2
2012 van Eyk, C., & Richards, R. (2012). Dynamic mutations: where are they now?. In A. Hannan (Ed.), Tandem repeat polymorphisms: genetic plasticity, neural diversity and disease (Vol. 769, pp. 55-77). Austin, Texas: Landes Bioscience and Springer Science+Business Media.
DOI Scopus8 WoS7 Europe PMC4
The Hospital Research Foundation Mid-career Fellowship (2020-2022): Genetic and epigenetic markers of neurodevelopmental disorders - a twin study; van Eyk, Clare Louise; TOTAL AMOUNT AWARDED: $480,000
Cerebral Palsy Alliance Research Foundation Research Grant (2019-2021): Uncovering the contribution of genetic mosaicism to cerebral palsy causation; van Eyk C, Gecz J, MacLennan A, Perez-Jurado L, Leventer R, Corbett M; TOTAL AMOUNT AWARDED: $140,000
Infrastructure funding Tenix Foundation, Administered by the Cerebral Palsy Alliance Research Foundation (2018-2021): The genetic origins of cerebral palsy; MacLennan, Alastair Harvey; Gecz, Jozef; van Eyk, Clare Louise; Corbett, Mark Adam; TOTAL AMOUNT AWARDED: $900,000
Cerebral Palsy Alliance Research Foundation Research Grant (2017-2019):Multi-omics investigations of cerebral palsy causation in discordant monozygotic twins and singletons; Gecz, Jozef; Craig, Jeffrey; MacLennan, Alastair Harvey; van Eyk, Clare Louise; Corbett, Mark Adam; TOTAL AMOUNT AWARDED: $261,442
NHMRC Project Grant (2016-2019): Genetic pathways to cerebral palsy; MacLennan, Alastair Harvey; van Eyk, Clare Louise; Corbett, Mark Adam; Newman, Morgan; Barnett, Christopher Patrick; Gecz, Jozef; Geschwind, Daniel; Kruer, Michael; Lardelli, Michael Trent; Russo, Remo N; Thompson, Suzanna Claire; Bent, Stephen; Smith, Nicholas; Broadbent, Jessica Louise;
TOTAL AMOUNT AWARDED: $1,314,158
Robinson Research Institute Investment for Success (2015); MacLennan, Alastair Harvey, van Eyk, Clare Louise; TOTAL AMOUNT AWARDED:$30,000
Cerebral Palsy Alliance Research Foundation Research Grant (2014-2016): Defining the role of genetic variations in cerebral palsy causation;
van Eyk, Clare Louise; Gecz, Jozef; MacLennan, Alastair Harvey; Geschwind, Daniel; TOTAL AMOUNT AWARDED: $298,996
National Ataxia Foundation - Post-Doc Fellowship Award (2013): A role for ADAR and TDP-43 RNA binding proteins as key mediators of toxicity in the autosomal dominant spinocerebellar ataxias; van Eyk, Clare Louise; Richards, Robert Ian;
TOTAL AMOUNT AWARDED: $35,000
Biomed IIB - Secondary Instructor
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 Co-Supervisor Genome and Epigenome Profiling of Disease-Discordant Monozygotic Twins for Cerebral Palsy Doctor of Philosophy Doctorate Full Time Miss Nandini Govindasamy Sandran
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2020 - ongoing Co-Supervisor Identification and validation of predictive biomarkers for cerebral palsy The University of Adelaide Molecular and Biomedical Sciences Honours Full Time Evdoxia Lagonik 2019 - ongoing Co-Supervisor WHOLE-GENOME SEQUENCING OF MONOZYGOTIC TWINS DISCORDANT FOR CEREBRAL PALSY University of Adelaide Masters Biotech. Master Full Time Nandini Sandran 2015 - 2015 Principal Supervisor Functional validation of genetic variants for cerebral palsy University of Adelaide — Honours Full Time Mahalia Frank
Date Role Membership Country 2019 - 2019 Member American Society of Human Genetics United States 2017 - ongoing Member International Cerebral Palsy Genomics Consortium Australia 2012 - 2013 Member Australian Society for Medical Research SA Scientific Meeting Committee — 2011 - 2013 Secretary Research Career Development Network Australia 2011 - 2013 — Australian Society for Medical Research — 2011 - 2011 Member Marketing and Outreach Committee, School of Molecular and Biomedical Science, University of Adelaide — 2011 - 2011 Chair Open Day Committee, School of Molecular and Biomedical Science, University of Adelaide —
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