Miss Karissa Barthelson
School of Biological Sciences
College of Sciences
All types of neurodegenerative diseases share common molecular mechanisms responsible for disease etiology and progression. I am interested in understanding these shared mechanisms, as targeting the common problems could lead to new therapeutics to benefit more individuals who live with these diseases.
To understand the shared molecular mechanisms, our research group utilises the small freshwater fish, the zebrafish, as a model organism. We introduce mutations into zebrafish which are equivalent to those which cause neurodegenerative diseases in humans (e.g. Alzheimer's disease, Sanfilippo syndrome childhood dementia), and analyse their brains with very high molecular detail.
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2021 | Award | The Harold Woolhouse Prize | The University of Adelaide | Australia | $1000 |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2017 - 2021 | University of Adelaide | Australia | Doctor of Philosophy |
| 2016 - 2016 | University of Adelaide | Australia | Bachelor of Science (Hons) |
| 2010 - 2015 | The University of Adelaide | Australia | Bachelor of Science |
| Date | Title | Institution | Country |
|---|---|---|---|
| 2021 - 2022 | Postdoctoral Research Officer | University of Adelaide | Australia |
| Year | Citation |
|---|---|
| 2025 | Barthelson, K., Protzman, R. A., Snel, M. F., Hemsley, K., & Lardelli, M. (2025). Multi-omics analyses of early-onset familial Alzheimer's disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.. Biochim Biophys Acta Mol Basis Dis, 1871(3), 167651. Scopus1 WoS1 |
| 2025 | Hillman, C., Fontana, B. D., Amstislavskaya, T. G., Gorbunova, M. A., Altenhofen, S., Barthelson, K., . . . Parker, M. O. (2025). Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study.. Lab Anim (NY), 54(6), 156-164. Scopus8 WoS7 Europe PMC5 |
| 2024 | Hillman, C., Fontana, B. D., Amstislavskaya, T. G., Gorbunova, M. A., Altenhofen, S., Barthelson, K., . . . Parker, M. O. (2024). Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.. Res Sq. |
| 2024 | Baer, L., Barthelson, K., Postlethwait, J. H., Adelson, D. L., Pederson, S. M., & Lardelli, M. (2024). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis.. PLoS Comput Biol, 20(2), e1011868. WoS1 Europe PMC1 |
| 2023 | Baer, L., Barthelson, K., Postlethwait, J., Adelson, D., Pederson, S., & Lardelli, M. (2023). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. bioRxiv. |
| 2023 | Allen, A. G., Barthelson, K., & Lardelli, M. (2023). pHAPE: a plasmid for production of DNA size marker ladders for gel electrophoresis.. Biol Methods Protoc, 8(1), bpad015. Scopus1 WoS1 Europe PMC1 |
| 2023 | Gerken, E., Ahmad, S., Rattan, L., Hemsley, K., Hemsley, K., Suo, S., . . . Lardelli, M. (2023). Zebrafish models of Mucopolysaccharidosis types IIIA, B, & C show hyperactivity and changes in oligodendrocyte state. Europe PMC2 |
| 2023 | Lardelli, M., Baer, L., Hin, N., Allen, A., Pederson, S. M., & Barthelson, K. (2023). The Use of Zebrafish in Transcriptome Analysis of the Early Effects of Mutations Causing Early Onset Familial Alzheimer's Disease and Other Inherited Neurodegenerative Conditions.. Journal of Alzheimer's disease : JAD, 99(s2), 1-15. Scopus6 WoS4 Europe PMC3 |
| 2023 | Barthelson, K., Protzman, R., Protzman, R., Snel, M., Snel, M., Hemsley, K., & Lardelli, M. (2023). Multi-omics analyses of early-onset familial Alzheimer’s disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms. |
| 2022 | Barthelson, K., Newman, M., & Lardelli, M. (2022). Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. Disease Models and Mechanisms, 15(1), 1-14. Scopus11 WoS7 Europe PMC6 |
| 2021 | Barthelson, K., Newman, M., & Lardelli, M. (2021). Comparative analysis of Alzheimer’s disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress. |
| 2021 | Dong, Y., Newman, M., Pederson, S. M., Barthelson, K., Hin, N., & Lardelli, M. (2021). Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics, 22(1), 211-1-211-16. Scopus16 WoS15 Europe PMC15 |
| 2021 | Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Differential effects of loss of<i>park7</i>activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease. |
| 2021 | Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2021). In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. Journal of Alzheimer's Disease Reports, 5(1), 395-404. Scopus10 WoS9 Europe PMC10 |
| 2021 | Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). PRESENILIN 1 mutations causing early-onset familial alzheimer's disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction. Journal of Alzheimers Disease, 82(1), 327-347. Scopus9 WoS9 Europe PMC10 |
| 2021 | Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.. Mol Brain, 14(1), 83. Scopus9 WoS9 Europe PMC8 |
| 2021 | Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., . . . Lardelli, M. (2021). Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in Genetics, 12, 1-11. Scopus4 WoS6 Europe PMC7 |
| 2021 | Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2021). Brain transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial alzheimer's disease indicates early effects on mitochondrial and ribosome function. Journal of Alzheimer's Disease, 79(3), 1105-1119. Scopus9 WoS9 Europe PMC11 |
| 2021 | Barthelson, K., Newman, M., Nowell, C. J., & Lardelli, M. (2021). No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene. Molecular Brain, 14(1), 22-1-22-4. Scopus2 WoS1 Europe PMC1 |
| 2021 | Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). <i>PRESENILIN 1</i>mutations causing early-onset familial Alzheimer’s disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction. Europe PMC1 |
| 2020 | Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease. biorxiv. |
| 2020 | Barthelson, K., Newman, M., & Lardelli, M. (2020). Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease. Journal of Alzheimer’s Disease Reports, 4(1), 123-140. Scopus29 WoS28 Europe PMC31 |
| 2020 | Jiang, H., Pederson, S. M., Newman, M., Dong, Y., Barthelson, K., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2. PLoS One, 15(7), e0232559-1-e0232559-25. Scopus9 WoS8 Europe PMC9 |
| 2020 | Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer's disease.. Molecular brain, 13(1), 142. Scopus27 WoS27 Europe PMC28 |
| 2020 | Barthelson, K., Pederson, S., Newman, M., & Lardelli, M. (2020). Transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains. biorxiv. Europe PMC1 |
| 2020 | Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2020). Frameshift and frame-preserving mutations in zebrafish presenilin 2 affect different cellular functions in young adult brains. Europe PMC2 |
| Year | Citation |
|---|---|
| 2014 | Jalali, S., Zeinali, M., & Nobakht, A. (2014). Effect of Goal Orientation on EFL Learners' Performances in CBT and PBT Across Gender. In K. Sadeghi, S. Modirkhameneh, P. Alavinia, & Z. A. Khonbi (Eds.), PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON CURRENT TRENDS IN ELT Vol. 98 (pp. 727-734). IRAN, Urmia Univ, Urmia: ELSEVIER SCIENCE BV. DOI WoS1 |
Genetics III
- Guest lecturer. 2018-2019, 2021.
- Practical Demonstrator. 2018-2021
Scientific Basis of Medicine II
- Tutor. 2021
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2024 | Co-Supervisor | Creation & phenotypic characterisation of a novel zebrafish model of Zellweger syndrome, an untreatable peroxisomal disorder resulting in childhood dementia. | Doctor of Philosophy | Doctorate | Full Time | Mr Lakshay Rattan |
| 2024 | Co-Supervisor | Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research | Doctor of Philosophy | Doctorate | Full Time | Miss Xinya Wang |
| 2024 | Co-Supervisor | Investigating the role of dihydroceramide desaturase in the brain using zebrafish | Doctor of Philosophy | Doctorate | Full Time | Mr Anqi Wang |
| 2024 | Co-Supervisor | Investigating the role of dihydroceramide desaturase in the brain using zebrafish | Doctor of Philosophy | Doctorate | Full Time | Mr Anqi Wang |
| 2024 | Co-Supervisor | Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research | Doctor of Philosophy | Doctorate | Full Time | Miss Xinya Wang |
| 2024 | Co-Supervisor | Creation & phenotypic characterisation of a novel zebrafish model of Zellweger syndrome, an untreatable peroxisomal disorder resulting in childhood dementia. | Doctor of Philosophy | Doctorate | Full Time | Mr Lakshay Rattan |
| 2022 | Co-Supervisor | Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models | Doctor of Philosophy | Doctorate | Full Time | Mr Kaijing Xu |
| 2022 | Co-Supervisor | Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models | Doctor of Philosophy | Doctorate | Full Time | Mr Kaijing Xu |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 - 2025 | Co-Supervisor | Investigating Early Molecular Drivers of Neurodegeneration by Modelling Parkinson's Disease in Zebrafish | Master of Philosophy | Master | Full Time | Miss Angel Grace Allen |
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