Karissa Barthelson
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
All types of neurodegenerative diseases share common molecular mechanisms responsible for disease etiology and progression. I am interested in understanding these shared mechanisms, as targeting the common problems could lead to new therapeutics to benefit more individuals who live with these diseases.
To understand the shared molecular mechanisms, our research group utilises the small freshwater fish, the zebrafish, as a model organism. We introduce mutations into zebrafish which are equivalent to those which cause neurodegenerative diseases in humans (e.g. Alzheimer's disease, Sanfilippo syndrome childhood dementia), and analyse their brains with very high molecular detail.
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Awards and Achievements
Date Type Title Institution Name Country Amount 2021 Award The Harold Woolhouse Prize The University of Adelaide Australia $1000 -
Education
Date Institution name Country Title 2017 - 2021 University of Adelaide Australia Doctor of Philosophy 2016 - 2016 University of Adelaide Australia Bachelor of Science (Hons) 2010 - 2015 The University of Adelaide Australia Bachelor of Science -
Postgraduate Training
Date Title Institution Country 2021 - 2022 Postdoctoral Research Officer University of Adelaide Australia
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Journals
Year Citation 2024 Lardelli, M., Baer, L., Hin, N., Allen, A., Pederson, S. M., & Barthelson, K. (2024). The Use of Zebrafish in Transcriptome Analysis of the Early Effects of Mutations Causing Early Onset Familial Alzheimer's Disease and Other Inherited Neurodegenerative Conditions. Journal of Alzheimer's Disease, 99(s2), S367-S381.
Scopus2 Europe PMC12024 Baer, L., Barthelson, K., Postlethwait, J. H., Adelson, D. L., Pederson, S. M., & Lardelli, M. (2024). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. PLoS Computational Biology, 20(2 February), 27 pages.
2023 Barthelson, K., Hemsley, K., & Lardelli, M. (2023). Transcriptome analysis of early-onset familial Alzheimer’s disease and Sanfilippo syndrome zebrafish models reveals commonalities in disease mechanisms.
2023 Baer, L., Barthelson, K., Postlethwait, J., Adelson, D., Pederson, S., & Lardelli, M. (2023). Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. bioRxiv.
2023 Allen, A. G., Barthelson, K., & Lardelli, M. (2023). PHAPE: A plasmid for production of DNA size marker ladders for gel electrophoresis. Biology Methods and Protocols, 8(1), 8 pages.
2023 Gerken, E., Ahmad, S., Rattan, L., Hemsley, K., Hemsley, K., Barthelson, K., & Lardelli, M. (2023). Zebrafish models of Mucopolysaccharidosis types IIIA, B, & C show hyperactivity and changes in oligodendrocyte state.
2022 Barthelson, K., Newman, M., & Lardelli, M. (2022). Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. Disease Models and Mechanisms, 15(1), 1-14.
Scopus5 WoS1 Europe PMC22021 Barthelson, K., Newman, M., & Lardelli, M. (2021). Comparative analysis of Alzheimer’s disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress.
2021 Dong, Y., Newman, M., Pederson, S. M., Barthelson, K., Hin, N., & Lardelli, M. (2021). Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics, 22(1), 211-1-211-16.
Scopus9 WoS6 Europe PMC52021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Differential effects of loss of<i>park7</i>activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease.
2021 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2021). In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. Journal of Alzheimer's Disease Reports, 5(1), 395-404.
Scopus7 WoS5 Europe PMC62021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). PRESENILIN 1 mutations causing early-onset familial alzheimer's disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction. Journal of Alzheimers Disease, 82(1), 327-347.
Scopus5 WoS2 Europe PMC52021 Chin, H. Y., Lardelli, M., Collins-Praino, L., & Barthelson, K. (2021). Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.. Mol Brain, 14(1), 83.
Scopus8 WoS6 Europe PMC52021 Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., . . . Lardelli, M. (2021). Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in Genetics, 12, 1-11.
Scopus3 Europe PMC42021 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2021). Brain transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial alzheimer's disease indicates early effects on mitochondrial and ribosome function. Journal of Alzheimer's Disease, 79(3), 1105-1119.
Scopus7 WoS4 Europe PMC62021 Barthelson, K., Newman, M., Nowell, C. J., & Lardelli, M. (2021). No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene. Molecular Brain, 14(1), 22-1-22-4.
Scopus1 WoS1 Europe PMC12021 Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. (2021). <i>PRESENILIN 1</i>mutations causing early-onset familial Alzheimer’s disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction.
2020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease. biorxiv.
2020 Barthelson, K., Newman, M., & Lardelli, M. (2020). Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease. Journal of Alzheimer’s Disease Reports, 4(1), 123-140.
Scopus19 WoS13 Europe PMC132020 Jiang, H., Pederson, S. M., Newman, M., Dong, Y., Barthelson, K., & Lardelli, M. (2020). Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2. PLoS One, 15(7), e0232559-1-e0232559-25.
Scopus6 WoS3 Europe PMC42020 Barthelson, K., Pederson, S. M., Newman, M., & Lardelli, M. (2020). Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer's disease.. Molecular brain, 13(1), 142.
Scopus21 WoS14 Europe PMC152020 Barthelson, K., Pederson, S., Newman, M., & Lardelli, M. (2020). Transcriptome analysis of a protein-truncating mutation in sortilin-related receptor 1 associated with early-onset familial Alzheimer’s disease indicates effects on mitochondrial and ribosome function in young-adult zebrafish brains. biorxiv.
2020 Barthelson, K., Pederson, S. M., Newman, M., Jiang, H., & Lardelli, M. (2020). Frameshift and frame-preserving mutations in zebrafish presenilin 2 affect different cellular functions in young adult brains.
Genetics III
- Guest lecturer. 2018-2019, 2021.
- Practical Demonstrator. 2018-2021
Scientific Basis of Medicine II
- Tutor. 2021
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Creation & phenotypic characterisation of a novel zebrafish model of Zellweger syndrome, an untreatable peroxisomal disorder resulting in childhood dementia. Doctor of Philosophy Doctorate Full Time Mr Lakshay Rattan 2024 Co-Supervisor Molecular Genetic and Omics Analyses in Neurodegenerative Disease Research Doctor of Philosophy Doctorate Full Time Miss Xinya Wang 2024 Co-Supervisor Investigating the role of dihydroceramide desaturase in the brain using zebrafish Doctor of Philosophy Doctorate Full Time Mr Anqi Wang 2023 Co-Supervisor Investigating Early Molecular Drivers of Neurodegeneration by Modelling Parkinson's Disease in Zebrafish Master of Philosophy Master Full Time Miss Angel Grace Allen 2022 Co-Supervisor Investigating Alzheimer's disease and MPS III mutant gene using Zebrafish and Drosophila genetic models Doctor of Philosophy Doctorate Full Time Mr Kaijing Xu
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