Lukas Gerstweiler

Lukas Gerstweiler

Higher Degree by Research Candidate

School of Chemical Engineering and Advanced Materials

Faculty of Engineering, Computer and Mathematical Sciences

My research concentrates on the production and purification of bacterial derived chimeric virus-like-particles (VLPs) as future vaccine candidates. I am examining several bottlenecks during downstream processing, like aggregation,interaction with host cell DNA and overall process yield. Of special interest are are the use of mixed mode chromatographic materials for advanced process integration, continuous chromatographic processes for protein purification, adsorption kinetics of large molecules on chromatographic resins, model based optimization and upscaling.  

  • Journals

    Year Citation
    2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 116272.

Programming (Matlab and C)

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