School of Chemical Engineering and Advanced Materials
Faculty of Sciences, Engineering and Technology
I am interested in the efficient production and purification of biomolecules and novel therapeutics, such as vaccines, virus-like particles, mRNA/DNA and antibodies. My research concentrates on process intensification and the transition from batch to continuous manufacturing applying continuous multi-column chromatography systems and advanced process integration strategies. Another research field is in-silico simulation of chromatography for process development and up-scaling, and advanced control strategies using artificial intelligence
Date Position Institution name 2022 - ongoing Lecturer The University of Adelaide 2017 - 2017 Intern Bardehle & Pagenberg 2016 - 2017 Student assistant Fraunhofer Institute for Process Engineering and Packaging
Language Competency English Can read, write, speak, understand spoken and peer review German Can read, write, speak, understand spoken and peer review
Date Institution name Country Title University of Hohenheim Germany Bc. Sc. Food Science and Biotechnology Technical University Munich Germany M.Sc. Pharmaceutical Bioprocess Engineering
Year Citation 2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration. Journal of Chromatography A, 1667, 8 pages.
DOI Scopus1 WoS1
2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). An integrated and continuous downstream process for microbial virus-like particle vaccine biomanufacture. Biotechnology and Bioengineering, 12 pages.
2021 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2021). Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies. Journal of Chromatography A, 1639, 1-11.
DOI Scopus2 WoS2
2021 Gerstweiler, L., Bi, J., & Middelberg, A. (2021). Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification. Biotechnology and Bioengineering, 118(4), 1688-1701.
DOI Scopus4 WoS5 Europe PMC2
2021 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2021). Front Cover Image, Volume 118, Number 4, April 2021. Biotechnology and Bioengineering, 118(4).
2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 231, 1-17.
DOI Scopus7 WoS5
CHEM ENG 7065 - Batch and Continuous Biomanufacturing
CHEM ENG 4074 - Brewery Engineering
CHEM ENG 2073 - Food Engineering
BIOTECH 3000 - Biotechnology Practice III
Connect With Me