Lukas Gerstweiler

Lukas Gerstweiler

School of Chemical Engineering and Advanced Materials

Faculty of Sciences, Engineering and Technology


I am interested in the efficient production and purification of biomolecules and novel therapeutics, such as vaccines, virus-like particles, mRNA/DNA and antibodies. My research concentrates on process intensification and the transition from batch to continuous manufacturing applying continuous multi-column chromatography systems and advanced process integration strategies. Another research field is in-silico simulation of chromatography for process development and up-scaling, and advanced control strategies using artificial intelligence 

 

  • Journals

    Year Citation
    2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration. Journal of Chromatography A, 1667, 8 pages.
    DOI Scopus1 WoS1
    2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). An integrated and continuous downstream process for microbial virus-like particle vaccine biomanufacture. Biotechnology and Bioengineering, 12 pages.
    DOI
    2021 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2021). Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies. Journal of Chromatography A, 1639, 1-11.
    DOI Scopus2 WoS2
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. (2021). Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification. Biotechnology and Bioengineering, 118(4), 1688-1701.
    DOI Scopus4 WoS5 Europe PMC2
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2021). Front Cover Image, Volume 118, Number 4, April 2021. Biotechnology and Bioengineering, 118(4).
    DOI
    2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 231, 1-17.
    DOI Scopus7 WoS5

CHEM ENG 7065 - Batch and Continuous Biomanufacturing

CHEM ENG 4074 - Brewery Engineering

CHEM ENG 2073 - Food Engineering

BIOTECH 3000 - Biotechnology Practice III


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