School of Chemical Engineering
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
- My Research
- Grants and Funding
- Professional Activities
Welcome to the captivating world of biomanufacturing research, where cutting-edge scientific breakthroughs are transforming the way we produce life-saving therapeutics, revolutionary protein-based foods, and next-generation vaccines. As a lecturer at The University of Adelaide, I am dedicated to exploring and advancing the frontiers of continuous biomanufacturing, downstream processing, chromatography, and virus-like particle (VLP) technology. In this brief overview, I will introduce you to my research interests and shed light on the exciting possibilities that lie ahead.
Continuous Biomanufacturing and Process Intensification:
At the forefront of my research lies the development and optimization of continuous biomanufacturing processes. By moving away from traditional batch-based methods, we are pioneering integrated manufacturing approaches that facilitate the streamlined production of biotherapeutics, recombinant proteins, mRNA-based medicines, and even recombinant food proteins. By enhancing process efficiency, reducing costs, and ensuring consistent quality, continuous biomanufacturing holds immense potential to revolutionize the healthcare and food industries.
Downstream Processing and Chromatography Innovations:
In the pursuit of efficient and sustainable biomanufacturing, my research delves into downstream processing and chromatography, a critical step in isolating and purifying biotherapeutics and proteins. A particular focus of my work revolves around novel resin materials based on porous co-polymers. These advanced materials offer increased selectivity, improved separation capabilities, and enhanced productivity, paving the way for more efficient and environmentally friendly purification processes.
Mechanistic Modeling and Process Optimization:
To optimize chromatographic purification and overcome the challenges posed by complex biomolecules, my research incorporates mechanistic modeling techniques. By employing computational approaches and mathematical modeling, we gain valuable insights into the intricate interactions between biomolecules and chromatographic systems. This deeper understanding enables us to fine-tune purification processes, maximize product yield, minimize production costs, and accelerate the delivery of life-saving therapies to patients worldwide.
Virus-Like Particle (VLP) Technology and Vaccine Platforms:
Viruses have long been a significant challenge in public health, but they also offer a unique opportunity to harness their structural properties for novel vaccine development. My research explores the manufacturing of Virus-Like Particles (VLPs) and the creation of innovative VLP-based vaccine platforms. By leveraging the self-assembling nature of VLPs, we aim to engineer safe and effective vaccines against a wide range of diseases, including those caused by emerging pathogens. These breakthroughs hold promise for providing rapid responses to pandemics and protecting global health.
As we move forward, my research group seeks to collaborate with motivated students and researchers who share our passion for biomanufacturing advancements. Through our multidisciplinary approach, we aim to integrate engineering, biology, and computational sciences to drive transformative innovations. Our overarching goal is to contribute to a future where life-saving medicines are more accessible, sustainable protein production is realized, and global health threats are effectively addressed.
Date Position Institution name 2022 - ongoing Lecturer The University of Adelaide 2017 - 2017 Intern Bardehle & Pagenberg 2016 - 2017 Student assistant Fraunhofer Institute for Process Engineering and Packaging
Language Competency English Can read, write, speak, understand spoken and peer review German Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2022 The University of Adelaide Australia PhD University of Hohenheim Germany Bc. Sc. Food Science and Biotechnology Technical University Munich Germany M.Sc. Pharmaceutical Bioprocess Engineering
Year Citation 2023 Gerstweiler, L. (2023). Model based process optimisation of an industrial chromatographic process for separation of lactoferrin from bovine milk. Poster session presented at the meeting of Bioprocessing Network conference. Melbourne. 2023 Gerstweiler, L., Schad, P., Trunzer, T., Enghauser, L., Meyr, M., & Billakanti, J. (2023). Model based process optimisation of an industrial chromatographic process for separation of lactoferrin from bovine milk. Poster session presented at the meeting of ISPPP. 2023 Gerstweiler, L. (2023). Model based process optimisation of an industrial chromatographic process for separation of lactoferrin from bovine milk. Poster session presented at the meeting of Protein Australia. 2022 Gerstweiler, L., Bi, J., Lua, L., & Middelberg, A. (2022). Influence of DNA-protein interactions on purification and assembly of virus-like particles. Poster session presented at the meeting of Vaccine Technology VIII. Barcelona. 2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2022). Continuous and integrated downstream process for in-vitro assembled virus like particles. Poster session presented at the meeting of Recovery XIX. Rome, Italy. 2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2022). High throughput process development for downstream processing of virus-like particle vaccines based on murine polyomavirus VLP platform. Poster session presented at the meeting of Chemeca 2022.
Original Creative Works
Year Citation 2022 Authors: Gerstweiler L, Billakanti J, Bi J, Middelberg APJ. Title: Cover Image, Volume 119, Number 8, August 2022. Description: N/A. Extent: 1 Page Cover Image.
2021 Authors: Gerstweiler L. Title: Front Cover Image, Volume 118, Number 4, April 2021. Description: N/A. Extent: 1 page cover design.
- MRFF - Develop enabling technologies for manufacture of precision mRNA vaccines
Pore-Size Adjustable Porous Materials for Purification Purposes
- University Research Small Equipment Support Scheme
- Healthy Societies FAME Strategy Internal Grant
- Mechanistic modelling for lactoferrin (LF) from bovine milk
CHEM ENG 7065 - Batch and Continuous Biomanufacturing
CHEM ENG 7062 - Downstream Bioprocessing
CHEM ENG 4074 - Brewery Engineering
CHEM ENG 7063 – Good Manufacturing Practice
CHEM ENG 4036 – Pharmaceutical Process Validation
BIOTECH 3000 - Biotechnology Practice III
CHEM ENG 4056 Process Design IV
CHEM ENG 4014 Plant Design
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Whole Organism Analytics using Free-Living Nematodes - Astropharmacy Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Laura Jasmine Beckett 2023 Co-Supervisor Development of Analyte sensitive Fluorescent Aerogels for Space Applications. Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Alexandra Nia Thomas 2023 Principal Supervisor Development of continuous bioprocess for production of virus-like particle vaccines (up- and downstream) Doctor of Philosophy Doctorate Full Time Mr Yannis Hendrik Karavias 2023 Principal Supervisor Comparative Analysis of mRNA Loading, Cargo Release, and Cellular Uptake Between Virus-Like Particles and Lipid Nanoparticles Doctor of Philosophy Doctorate Full Time Mr Xiaoyan Wang 2023 Principal Supervisor Fundamental study of chimeric protein molecular design and stability Doctor of Philosophy Doctorate Full Time Miss Hong Luo 2023 Principal Supervisor Investigation of mechanistic and structural requirements for the formation of unwanted by-products during in-vitro transcription Doctor of Philosophy Doctorate Full Time Ms Cinderella Janine Angela Nowak 2022 Co-Supervisor Development of mRNA loaded Lipid Nanoparticles for CAR T Cell Therapy Doctor of Philosophy Doctorate Full Time Ms Minh Trang Ho
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 - 2023 Principal Supervisor Stability Study of Engineered Ferritin Nano-vaccines by Combined Molecular simulation and Experiments Master of Philosophy Master Full Time Ms Yang Yang
Date Role Membership Country 2023 - ongoing Member IChemE Australia 2023 - ongoing Member IMNIS catalyst Australia 2020 - ongoing Treasurer Adelaide University Waterski Club Australia
Date Event Name Event Type Institution Country 2023 - 2023 CARST industry engagement panel Seminars University fo Adelaide - 2023 - 2023 Visionary leadership: connecting the pathways Plenary or general session ATSE - 2023 - ongoing HDR supervision webinar: Supervising research students flexibility Workshop The University of Adelaide -
Date Engagement Type Partner Name 2022 - 2023 Collaboration Cytiva 2022 - ongoing Collaboration Holocyte
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