Lukas Gerstweiler

Lukas Gerstweiler

School of Chemical Engineering and Advanced Materials

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

My research focuses on efficient and cost effective production of biotherapeutics such as virus-like particle vaccines and alternative proteins for the food industries.


In particular I am interested in improving the purification (downstream processing) using chromatographic techniques. The main areas I am looking at is the transition from batch to continuous manufacturing using periodic counter current chromatography, in-silico mechanistic modelling of chromatographic systems and higher automation using AI and model driven decision making. 

I am also developing platform approaches for low-cost virus-like particle vaccines and other protein nanoparticles.

If you are interested or have trouble in purifying proteins or want to know if continuous manufacturing is an option for you reach out to me.


  • Journals

    Year Citation
    2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration. Journal of Chromatography A, 1667, 8 pages.
    DOI Scopus2 WoS2
    2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). An integrated and continuous downstream process for microbial virus-like particle vaccine biomanufacture. Biotechnology and Bioengineering, 119(8), 2122-2133.
    2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Cover Image, Volume 119, Number 8, August 2022. Biotechnology and Bioengineering, 119(8).
    2021 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2021). Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies. Journal of Chromatography A, 1639, 1-11.
    DOI Scopus2 WoS2
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. (2021). Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification. Biotechnology and Bioengineering, 118(4), 1688-1701.
    DOI Scopus4 WoS6 Europe PMC2
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2021). Front Cover Image, Volume 118, Number 4, April 2021. Biotechnology and Bioengineering, 118(4).
    2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 231, 1-17.
    DOI Scopus11 WoS8

Mechanistic modelling for lactoferrin (LF) from bovine milk - Industry project

CHEM ENG 7065 - Batch and Continuous Biomanufacturing

CHEM ENG 7062 - Downstream Bioprocessing

CHEM ENG 4074 - Brewery Engineering

CHEM ENG 7063 – Good Manufacturing Practice

CHEM ENG 4036 – Pharmaceutical Process Validation

BIOTECH 3000 - Biotechnology Practice III

CHEM ENG 4056 Process Design IV

CHEM ENG 4014 Plant Design

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