School of Chemical Engineering
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
My research focuses on efficient and cost effective production of biotherapeutics such as virus-like particle vaccines and alternative proteins for the food industries.
In particular I am interested in improving the purification (downstream processing) using chromatographic techniques. The main areas I am looking at is the transition from batch to continuous manufacturing using periodic counter current chromatography, in-silico mechanistic modelling of chromatographic systems and higher automation using AI and model driven decision making.
I am also developing platform approaches for low-cost virus-like particle vaccines and other protein nanoparticles.
If you are interested or have trouble in purifying proteins or want to know if continuous manufacturing is an option for you reach out to me.
Date Position Institution name 2022 - ongoing Lecturer The University of Adelaide 2017 - 2017 Intern Bardehle & Pagenberg 2016 - 2017 Student assistant Fraunhofer Institute for Process Engineering and Packaging
Language Competency English Can read, write, speak, understand spoken and peer review German Can read, write, speak, understand spoken and peer review
Date Institution name Country Title University of Hohenheim Germany Bc. Sc. Food Science and Biotechnology Technical University Munich Germany M.Sc. Pharmaceutical Bioprocess Engineering
Year Citation 2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration. Journal of Chromatography A, 1667, 8 pages.
DOI Scopus2 WoS2 Europe PMC2
2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). An integrated and continuous downstream process for microbial virus-like particle vaccine biomanufacture.. Biotechnol Bioeng, 119(8), 2122-2133.
DOI Europe PMC1
2022 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. P. J. (2022). Cover Image, Volume 119, Number 8, August 2022. Biotechnology and Bioengineering, 119(8).
2022 Li, Y., Yang, G., Gerstweiler, L., Thang, S. H. H., & Zhao, C. -X. (2022). Design of Stimuli-Responsive Peptides and Proteins. ADVANCED FUNCTIONAL MATERIALS, 31 pages.
2021 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2021). Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies. Journal of Chromatography A, 1639, 1-11.
DOI Scopus2 WoS2 Europe PMC1
2021 Gerstweiler, L., Bi, J., & Middelberg, A. (2021). Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification. Biotechnology and Bioengineering, 118(4), 1688-1701.
DOI Scopus4 WoS6 Europe PMC3
2021 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2021). Front Cover Image, Volume 118, Number 4, April 2021. Biotechnology and Bioengineering, 118(4).
2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 231, 1-17.
DOI Scopus12 WoS10
- University Research Small Equipment Support Scheme (2022)
- Healthy Societies FAME Strategy Internal Grant (2022)
- Mechanistic modelling for lactoferrin (LF) from bovine milk (2022)
CHEM ENG 7065 - Batch and Continuous Biomanufacturing
CHEM ENG 7062 - Downstream Bioprocessing
CHEM ENG 4074 - Brewery Engineering
CHEM ENG 7063 – Good Manufacturing Practice
CHEM ENG 4036 – Pharmaceutical Process Validation
BIOTECH 3000 - Biotechnology Practice III
CHEM ENG 4056 Process Design IV
CHEM ENG 4014 Plant Design
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Stability Study of Engineered Ferritin Nano-vaccines by Combined Molecular Simulation and Experiments Master of Philosophy Master Full Time Ms Yang Yang 2022 Co-Supervisor Mechanical Modulation of Particle-Cell Interactions Doctor of Philosophy Doctorate Full Time Ms Minh Trang Ho
Connect With Me