Federico Moreno Sibaja

Federico Moreno Sibaja

Higher Degree by Research Candidate

School of Chemical Engineering

Faculty of Sciences, Engineering and Technology

Integrated Small-Scale Manufacturing of mRNA therapeutics

Recently, mRNA-based therapies and vaccines have revolutionized the pharmaceutical industry by providing unprecedented opportunities for replacing conventional therapies due to rapid vaccine development and precision medicine applications. However, there are several manufacturing challenges in the downstream processing, mainly mRNA instability and impurities, such as byproducts generated during In vitro transcription reaction, which are major bottlenecks for purification strategies. Therefore, effective, highly selective, and rapid purification is required. Though chromatography is currently employed for mRNA purification, it faces challenges due to similarities in properties between mRNA and nucleic acid byproducts. The aim of this work is the design, development, and optimization of chromatographic chips for mRNA therapeutics manufacturing.

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