Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr. Heilbronn is a translational investigator in obesity and diabetes research with a focus on the physiological and molecular basis of obesity. She has a particular interest in understanding how fasting activates nutrient signalling pathways to improve health and has contributed to current concepts in calorie restriction, intermittent fasting and time restricted eating. She has published more than 125 peer-reviewed manuscripts, and has a current h-index of 42. She is an Associate Editor of Obesity and Obesity Research and Clinical Practice. She is currently Vice President of the Australia and New Zealand Obesity Society and Associate Member of the Australian Academy of Health and Medical Science.
ASSOCIATE PROFESSOR LEONIE HEILBRONN leads the Obesity and Metabolism laboratory which is based within the Lifelong Health Theme at SAHMRI. Her research is primarily performed in humans with obesity, and is focused on understanding the impacts of nutritional modulation on insulin resistance and metabolism to reduce the risk of chronic disease. She has contributed to current concepts of caloric restriction (CR), intermittent fasting (IF) and time restricted eating (TRE) in humans and also interested in the developmental origins of obesity. Currently, she has projects that examine intermittent fasting and altering meal and macronutrient timing on glucose and lipid metabolism in humans.
Available Research Projects
Project 1 - Meal timing – does when you eat matter more than what you eat?
Project description: We currently have projects available examining the effects of meal timing and fasting length on metabolic health in preclinical models and in individuals at risk of type 2 diabetes. These studies involve laboratory based work (e.g. qPCR, immunohistochemistry, ELISA, RIA) examining the impact of these interventions on circadian rhythms, lipid metabolism and mitochondrial function, as well as conducting clinical studies in humans examining glucose by continuous glucose monitors, physical activity, diet and participant wellbeing.
Projects available for: Honours / HDR
Research project start: Anytime.
Special requirements: Hep B vaccination required
Date Position Institution name 2014 Senior Research Fellow South Australian Health and Medical Research Institute 2010 Group Leader, Obesity and Metabolism Lab The University of Adelaide 2005 - 2009 Research Fellow Garvan Institute of Medical Research 2002 - 2004 Postdoctoral Researcher Pennington Biomedical Research Center
Awards and Achievements
Date Type Title Institution Name Country Amount 2014 Award Diabetes Australia Research Trust Grant Award Australian Diabetes Society Australia — 2012 Fellowship ARC Future Fellowship Australian Research Council Australia 809,000 2010 Award Young Tall Poppy Science Award Australian Institute of Policy and Science Australia — 2008 Fellowship Career Development Award I Fellowship NHMRC Australia 370,000 2004 Fellowship Peter Doherty Biomedical Fellowship NHMRC Australia — 2004 Award The Glenn Award American Ageing Association United States — 1998 Award Ross Wishart Memorial Award for Best Student Oral Australian Society for Medical Research Australia —
Date Institution name Country Title 1998 - 2001 University of Adelaide Australia PhD 1997 - 1997 University of Adelaide Australia Bachelor of Science (Honours) 1994 - 1996 University of Adelaide Australia Bachelor of Science
Year Citation 2010 Everitt, A. V., Heilbronn, L. K., & Le Couteur, D. G. (2010). Food intake, life style, aging and human longevity. In Calorie Restriction, Aging and Longevity (pp. 15-41). Springer Netherlands.
2010 Everitt, A. V., Heilbronn, L. K., Morris, B. J., Brown-Borg, H. M., Merry, B. J., Simpson, S. J., . . . Le Couteur, D. G. (2010). Conclusion: Human calorie restriction and anti-aging therapy. In Calorie Restriction, Aging and Longevity (pp. 311-318). Springer Netherlands.
Year Citation 2018 Lee, T. F., Drake, S. M., Mangelsdorf, B. L., Roberts, G. W., Stranks, S. N., Bersten, A. D., . . . Burt, M. G. (2018). Relative hyperglycaemia is an independent predictor of mortality in the critically ill patient. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 23-24). Perth, AUSTRALIA: WILEY. 2018 Grant, C., Coates, A., Dorrian, J., Kennaway, D., Wittert, G., Heilbronn, L., . . . Banks, S. (2018). Glucose metabolism is impacted by timing of food intake during simulated night shift. In JOURNAL OF SLEEP RESEARCH Vol. 27 (pp. 1 page). Brisbane, AUSTRALIA: WILEY. 2018 Gupta, C., Dorrian, J., Centofanti, S., Coates, A., Kennaway, D., Wittert, G., . . . Banks, S. (2018). Eating a large meal during the nightshift may increase accident risk on the commute home. In JOURNAL OF SLEEP RESEARCH Vol. 27 (pp. 1 page). Brisbane, AUSTRALIA: WILEY. 2016 Gupta, C., Dorrian, J., Grant, C., Pajcin, M., Coates, A., Kennaway, D., . . . Banks, S. (2016). Eating during the nightshift: the impact of meal timing on driving performance during simulated shift work. In JOURNAL OF SLEEP RESEARCH Vol. 25 (pp. 105-106). Bologna, ITALY: WILEY-BLACKWELL. 2010 Samocha-Bonet, D., Turner, N., Mori, T. A., Croft, K., Viardot, A., Tam, C. S., . . . Heilbronn, L. K. (2010). Short-Term Overfeeding and Moderate Weight Gain Induces Peripheral Insulin Resistance and Increases Systemic Oxidative Stress in Healthy Humans. In DIABETES Vol. 59 (pp. A422). Orlando, FL: AMER DIABETES ASSOC. 2003 Atwood, C. S., Barzilai, N., Bowen, R. L., Brown-Borg, H. M., Jarrard, D. F., Fu, V. X., . . . Weindruch, R. (2003). Pennington Scientific Symposium on Mechanisms and Retardation of Aging. In Experimental Gerontology Vol. 38 (pp. 1217-1226). England: Elsevier BV.
DOI Scopus7 Europe PMC4
Year Citation 2019 Matthews, R., Roma, P., Hursh, S., Centofanti, S., Yates, C., Stepien, J., . . . Banks, S. (2019). Team Cohesion under sleep loss. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. Sydney, AUSTRALIA: WILEY. 2019 Stepien, J., Dorrian, J., Kennaway, D., Coates, A., Yates, C., Centofanti, S., . . . Banks, S. (2019). Individual variation in melatonin responses under constant lighting (100lux) during simulated night shiftwork. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. Sydney, AUSTRALIA: WILEY. 2019 Liu, B., Hutchison, A., Thompson, C., Wittert, G. A., & Heilbronn, L. K. (2019). Weight loss and tissue remodelling following 8-week calorie restriction or intermittent fasting in females who are overweight and obese. Poster session presented at the meeting of Obesity Research and Clinical Practice. Elsevier. 2018 Gupta, C., Dorrian, J., Centofanti, S., Coates, A., Kennaway, D., Wittert, G., . . . Banks, S. (2018). Meal inertia: the impact of eating different sized meals on vigilant attention throughout the night. Poster session presented at the meeting of Abstracts of the 32nd Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS 2018), as published in Sleep. Baltimore, MD: Oxford University Press.
2017 Gyawali, P., Martin, S. A., Heilbronn, L. K., Taylor, A. W., Adams, R. J., O Loughlin, P. D., & Wittert, G. A. (2017). Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in community-dwelling men: the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study. Poster session presented at the meeting of CLINICAL ENDOCRINOLOGY. WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL. 2017 Gupta, C., Dorrian, J., Centofanti, S., Coates, A., Kennaway, D., Wittert, G., . . . Coro, D. (2017). THE IMPACT OF A MEAL, SNACK, OR NOT EATING DURING THE NIGHTSHIFT ON DRIVING PERFORMANCE. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. Auckland, NEW ZEALAND: WILEY.
2017 Stepien, J., Dorrian, J., Centofanti, S., Coates, A., Kennaway, D., Wittert, G., . . . Banks, S. (2017). PRELIMINARY INVESTIGATION OF THE VARIABILITY IN MELATONIN ONSET IN SELF-REPORTED INTERMEDIATE CHRONOTYPES. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. Auckland, NEW ZEALAND: WILEY.
2017 Liu, B., Hutchison, A. T., Thompson, C. H., Wittert, G. A., & Heilbronn, L. (2017). Adipose tissue remodeling following eight-week calorie restriction or intermittent fasting in females who are overweight and obese. Poster session presented at the meeting of Diabetes. San Diego, CA: American Diabetes Association.
2017 Gyawali, P., Martin, S. A., Heilbronn, L. K., Taylor, A. W., Adams, R. J. T., O'Loughlin, P. D., & Wittert, G. A. (2017). CROSS-SECTIONAL AND LONGITUDINAL DETERMINANTS OF SERUM SEX HORMONE BINDING GLOBULIN (SHBG) IN COMMUNITY-DWELLING MEN: THE MEN ANDROGEN INFLAMMATION LIFESTYLE ENVIRONMENT AND STRESS (MAILES) STUDY. Poster session presented at the meeting of JOURNAL OF SEXUAL MEDICINE. WILEY. 2016 Gupta, C., Dorrian, J., Grant, C., Pajcin, M., Coates, A., Kennaway, D., . . . Banks, S. (2016). DRIVING PERFORMANCE IS WORSE AFTER EATING DURING THE NIGHTSHIFT. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. WILEY-BLACKWELL. 2016 Grant, C., Dorrian, J., Coates, A., Kennaway, D., Wittert, G., Heilbronn, L., . . . Banks, S. (2016). EATING VS. NOT EATING AT NIGHT DIFFERENTIALLY AFFECTS PERFORMANCE DURING THE NIGHTSHIFT. Poster session presented at the meeting of JOURNAL OF SLEEP RESEARCH. WILEY-BLACKWELL.
2016 Grant, C., Coates, A., Dorrian, J., Kennaway, D., Wittert, G., Heilbronn, L., . . . Banks, S. (2016). Eating on Simulated Night Shift Effects Glucose Response to Breakfast: Pilot Study. Poster session presented at the meeting of FASEB JOURNAL. San Diego, CA: FEDERATION AMER SOC EXP BIOL.
2016 Elshorbagy, A. K., Jerneren, F., Samocha-Bonet, D., Refsum, H., & Heilbronn, L. K. (2016). Plasma S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. Poster session presented at the meeting of AMINO ACIDS. SPRINGER WIEN. 2013 Chen, M., Wu, L., Norman, R., Robker, R., Wittert, G., & Heilbronn, L. (2013). Altered Glucose Metabolism in Mice and Humans Conceived by In Vitro Fertilisation. Poster session presented at the meeting of DIABETES. AMER DIABETES ASSOC. 2013 Chen, M., Wu, L., Wittert, G. A., Norman, R. J., Robker, R. L., & Heilbronn, L. K. (2013). Distinct adult metabolic consequences following ovarian stimulation versus in vitro culture of mouse embryos. Poster session presented at the meeting of Oral and Poster Session Abstracts of the International Federation of Fertility Societies 21st World Congress on Fertility and Sterility and the 69th Annual Meeting of the American Society for Reproductive Medicine, as published in Fertility and Sterility. Boston, MA: Elsevier.
2013 Chen, M., Zhao, J., Davies, M. J., Wittert, G. A., Norman, R. J., & Heilbronn, L. K. (2013). Decreased insulin sensitivity in young adults born through in vitro fertilisation (IVF) and higher systolic blood pressure following high fat overfeeding. Poster session presented at the meeting of Oral and Poster Session Abstracts of the International Federation of Fertility Societies 21st World Congress on Fertility and Sterility and the 69th Annual Meeting of the American Society for Reproductive Medicine, as published in Fertility and Sterility. Boston, MA: Elsevier.
|Date||Project/ No.||Investigators||Funding Body||Amount|
|2021-3||Moderate protein intake counteracts Alzheimer’s disease: examination of nutrition signaling and the lysosomal system.||Sargeant, Heilbronn, Bensalem||Bright Focus Foundation||360,000|
Time Restricted EATing to reduce the risk of developing type 2 diabetes (TREAT)
Heilbronn LK, Hawley J, Hutchison A, Devlin B, Parr E
|2020-22||Varying meal timing impacts on type 2 diabetes risk||Heilbronn LK||THRF||122,000|
Will a protein pre-load before the evening meal improve glucose tolerance in shift workers?
|Hutchison, Heilbronn, Banks||Diabetes Australia Research Program||58,000|
|2019-2022||A novel nutrient supplement with potent appetite-supressant and glucose lowering effects – translating clinical research into an innovative treatment for obesity and type 2 diabetes. APP||Feinle-Bisset C, Heilbronn LK, Poppit S||NHMRC||964,000|
|2018-2021||Intermittent fasting versus daily caloric restriction for improved health in individuals at risk of type 2 diabetes APP1143092||Heilbronn LK, Feinle-Bisset||NHMRC||987,000|
|2018||Time restricted feeding, glycemic control and the adipose tissue transcriptome||Heilbronn, Wittert, Banks||Diabetes Australia Research Program (DARP) $60,000|
|2016 - 2019||Altering meal times to reverse metabolic consequences of shift work/Project ID APP1099077||Banks S, Heilbronn LK, Kennaway D, Coates A, Dorian J||NHMRC||770,000|
|2016||Sex hormone binding globulin (SHBG) as a marker of aggressive prostate cancer and mediator of resistance to androgen deprivation||Wittert GA, Butler LM, Hoy A, Vincent A, Heilbronn L, Selth L||Royal Adelaide Hospital Clinical Project Grant||48,433|
|2016||Is mitochondrial dysfunction in IVF blastocysts responsible for impaired glucose metabolism in offspring?||Robker RL, Heilbronn LK, Chen M, Wu L||Diabetes Australia Research Program (DARP)||60,000|
|2015||Determination of the effect of relative hyperglycaemia on markers of cardiovascular risk||Burt MG, Mangoni A, Heilbronn L||Faculty of Health Science, Flinders University||19,000|
|2015||Intermittent fasting for weight loss and metabolic health, does meal timing matter?||Heilbronn LK, Wittert GA, Hutchison A||Royal Adelaide Hospital Research Committee||50,000|
|2014||Examining the time course of the insulin sensitising effect of hyperbaric oxygen therapy||DW Wilkinson, IA Chapman, LK Heilbronn||Australian Diving and Hyperbaric Medicine Research Trust||32,000|
|2014||Can 6 minutes of high intensity exercise mitigate the adverse effects of an overfeeding diet?||Royal Adelaide Hospital Research Committee||50,000|
|2014||Effects of intermittent fasting on the inflammatory profile in serum and adipose tissue||LK Heilbronn||Diabetes Australia Research Trust (DART)||60,000|
|2013||Metabolic monitoring in animal models of obesity||AJ Page, LK Heilbronn, RL Young, SM Brierly, TJ Little||NHMRC Equipment Grant||94.864|
|2012 - 2015||Does periodic fasting improve insulin sensitivity and metabolic health in humans? Project grant APP1023401||LK Heilbronn, GA Wittert||NHMRC||809,130|
|2012||Does hyperbaric oxygen therapy alter insulin sensitivity in humans?||LK Heilbronn||Diabetes Australia Research Trust (DART)||60,000|
|2012||Does IVF impair insulin sensitivity in humans||LK Heilbronn, RJ Norman, M Davies||Channel 7 Foundation||75,000|
|2011||Is insulin sensitivity improved by hyperbaric oxygen therapy?||LK Heilbronn||Mary Overton New Investigator Project Grant, RAH||50,000|
|2011||Studies in Nutritional Physiology and Related Diseases||Wittert G, Horowitz M, Chapman I, Rayner C, Feinle-Bisset C, Jones KL, Heilbronn LK||NHMRC Equipment grant||25,000|
|2010||Metabolic phenotyping of individuals born through in-vitro fertilization||LK Heilbronn, RJ Norman||Robinson Institute Collaborative Research Funding Scheme||10,000|
|2009||Measuring Insulin Sensitivity in Humans||LK Heilbronn, GA Wittert, RJ Norman||NHMRC Equipment Grant||20,000|
|2008||Measuring energy expenditure and fat oxidation in type 2 diabetes||LK Heilbronn, LV Campbell, DJ Chisholm||Rebecca L. Cooper Foundation Equipment Grant||20,000|
|2008||Adipose tissue macrophages and insulin resistance in humans||LK Heilbronn||Diabetes Australia Research Trust (DART)||50,000|
|2007- 2009||Short-Term Effects of Overfeeding on Skeletal Muscle Plasticity and Metabolic Risk in Humans/ Project ID 427639||LK Heilbronn, LV Campbell||NHMRC Project Grant||400,625|
|2003||Effects of intermittent fasting on genes involved in oxidative phosphorylation and fat oxidation||LK Heilbronn||Pennington Biomedical Research Grant for Young Investigators||60,000|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 Principal Supervisor Nutritional strategies to improve health in individuals at high risk for developing type 2 diabetes Doctor of Philosophy Doctorate Full Time Mrs Rasha Charrouf 2019 Principal Supervisor Effect of meal timing and intermittent fasting on metabolic health Doctor of Philosophy Doctorate Full Time Miss Kai Julia Liu 2018 Principal Supervisor Intermittent Fasting Versus Calorie Restriction to Reduce Risk of Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Miss Xiao Tong Teong 2017 Co-Supervisor Altered Dietary Intake in Mice and the Prolonged Effects on Glucose Tolerance Doctor of Philosophy Doctorate Full Time Miss Rebecca Jane O'Rielly 2017 Principal Supervisor Impact of prolonged fasting and shiftwork in Autophagy and Telomere and risk of Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Mr Rajesh Chaudhary 2017 Principal Supervisor The Metabolic Impacts of Fasting and Time Restricted Feeding in Humans at Risk of Type 2 Diabetes Doctor of Philosophy Doctorate Full Time Miss Lijun Zhao
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2021 Principal Supervisor Impact of Time Restricted Feeding on Glucose Metabolism and Metabolic Health Doctor of Philosophy Doctorate Full Time Mr Prashant Regmi 2015 - 2019 Co-Supervisor Sex Hormone-Binding Globulin: Regulation and Role as a Marker of Chronic Disease Risk Doctor of Philosophy Doctorate Full Time Dr Prabin Gyawali 2014 - 2018 Principal Supervisor Dietary Intervention and Tissue Remodelling Doctor of Philosophy Doctorate Full Time Dr Bo Liu 2012 - 2020 Co-Supervisor HYPERBARIC OXYGEN AND INSULIN SENSITIVITY Doctor of Philosophy Doctorate Part Time Dr David Wilkinson 2010 - 2011 Co-Supervisor The Effect of Dietary Fatty Acid Composition on Skeletal Muscle and Hepatic Fatty Acid and Glucose Metabolism in Male and Female Mice Doctor of Philosophy Doctorate Full Time Ms Lisa Philp 2010 - 2014 Principal Supervisor Metabolic Phenotyping of Young Adults and Mice Born Through In Vitro Fertilization (IVF) Doctor of Philosophy Doctorate Full Time Mr Miaoxin Chen
Date Role Committee Institution Country 2019 - ongoing Vice-President Australia New Zealand Obesity Society ANZOS Australia 2016 - ongoing Member NHMRC Academy Assigner National Health and Medical Research Council Australia 2015 - ongoing Member NHMRC Panel Member National Health and Medical Research Council Australia 2006 - 2008 Secretary ANZOS scientific meeting Australian & New Zealand Obesity Society Australia
Date Role Membership Country 2009 - ongoing Member Australian Diabetes Society (ADS) Australia 2009 - ongoing Member Australian New Zealand Obesity Society (ANZOS) Australia 1999 - ongoing Member Australian Diabetes Society (ADS) Australia
Date Role Editorial Board Name Institution Country 2018 - ongoing Associate Editor Obesity The University of Adelaide Australia 2016 - ongoing Editor Clinical Trials Corner, Nutrition and Healthy Aging — Australia 2015 - ongoing Associate Editor Obesity Research and Clinical Practice — —
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