Larisa Bobrovskaya

APrf Larisa Bobrovskaya

Associate Professor

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Available For Media Comment.

Larisa is a leading neuroscientist and biochemist within UniSA Clinical and Health Sciences with expertise in stress response, diabetes and neurological disorders. Her research focuses on investigation of cellular and biochemical mechanisms of diseases, identifying novel biomarkers and testing novel treatments using animal models. She leads a number of research projects and supervises PhD and Honours students.  
Larisa is also a passionate teacher. Her teaching philosophy is to provide students with the knowledge and skills that will allow them to successfully begin their professional career.  
My Research Gate Profile
My Google Scholar Publications

Our research focuses on the following areas

1. Neurological disorders such as Alzheimer’s disease, Parkinson’s disease, depression and stroke

2. Role of Gut-Brain axis and nutrition in neurological disorders

3. Mechanisms of hypoglycaemia-associated autonomic failure in diabetes

Year Citation
2025 Kelliny, S., Zhou, X. F., & Bobrovskaya, L. (2025). Alzheimer's disease and frontotemporal dementia: a review of pathophysiology and therapeutic approaches. Journal Of Neuroscience Research, 103(5, article no. e70046), 1-43.
DOI Scopus6 WoS6 Europe PMC4
2025 Braun, A., Racz, J., Garg, S., & Bobrovskaya, L. (2025). Further characterisation of the intrastriatal 6-OHDA Parkinson's disease model with non-motor symptom replication and widespread catecholamine dysfunction in male mice. Neurochemistry International, 190(106054), 106054.
DOI
2024 Cade, S., Prestidge, C., Zhou, X. F., & Bobrovskaya, L. (2024). The effects of a bioavailable curcumin formulation on Alzheimer's disease pathologies: A potential risk for neuroinflammation. Ibrain, 10(4), 391-547.
DOI Scopus1 Europe PMC1
2024 Matricciani, L., Dumuid, D., Stanford, T., Maher, C., Bennett, P., Bobrovskaya, L., . . . Olds, T. (2024). Time use and dimensions of healthy sleep: A cross-sectional study of Australian children and adults. Sleep Health, 10(3), 348-355.
DOI Scopus2 WoS2 Europe PMC1
2024 Senthilkumaran, M., Koch, C., Herselman, M. F., & Bobrovskaya, L. (2024). Role of the Adrenal Medulla in Hypoglycaemia-Associated Autonomic Failure-A Diabetic Perspective. METABOLITES, 14(2), 27 pages.
DOI Scopus4
2024 Braun, A., Manavis, J., Yamanaka, A., Ootsuka, Y., Blumbergs, P., & Bobrovskaya, L. (2024). The role of orexin in Parkinson's disease. Journal of Neuroscience Research, 102(3, article no. e25322), 1-24.
DOI Scopus7 WoS6 Europe PMC5
2023 Cade, S., Zhou, X. F., & Bobrovskaya, L. (2023). An imbalance in the pro/mature BDNF ratio occurs in multiple brain regions during normal ageing in wild-type mice. Journal Of Molecular Neuroscience, 73(6), 469-484.
DOI Scopus10 WoS9 Europe PMC8
2023 Herselman, M. F., Lin, L., Luo, S., Yamanaka, A., Zhou, X. F., & Bobrovskaya, L. (2023). Sex-Dependent Effects of Chronic Restraint Stress on Mood-Related Behaviours and Neurochemistry in Mice. International Journal of Molecular Sciences, 24(12), 10353-1-10353-19.
DOI Scopus11 WoS12 Europe PMC12
2023 Herselman, M. F., & Bobrovskaya, L. (2023). The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice. International Journal of Molecular Sciences, 24(19), 14618.
DOI Scopus4 WoS4 Europe PMC4
2022 Herselman, M. F., Bailey, S., & Bobrovskaya, L. (2022). The effects of stress and diet on the 'brain-gut' and 'gut-brain' pathways in animal models of stress and depression. International Journal of Molecular Sciences, 23(4, article no. 2013), 1-31.
DOI Scopus33 WoS28 Europe PMC24
2022 Bajic, J., Howarth, G., Mashtoub, S., Whittaker, A., Bobrovskaya, L., & Hutchinson, M. R. (2022). Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats. Journal of Neuroscience Research, 100(1), 237-250.
DOI Scopus3 WoS3 Europe PMC2
2022 Cade, S., Zhou, X. F., & Bobrovskaya, L. (2022). The role of brain-derived neurotrophic factor and the neurotrophin receptor p75NTR in age-related brain atrophy and the transition to Alzheimer's disease. Reviews in the Neurosciences, 33(5), 515-529.
DOI Scopus9 WoS8 Europe PMC12
2022 Liu, D., Rychkov, G., Hurtado, P., Luo, H. Y., Zhang, T., Bobrovskaya, L., & Zhou, X. F. (2022). Conversion of human fibroblasts into induced neural stem cells by small molecules. International Journal of Molecular Sciences, 23(3, article no. 1740), 1-12.
DOI Scopus5 WoS5 Europe PMC4
2022 Lin, L., Herselman, M. F., Zhou, X. F., & Bobrovskaya, L. (2022). Effects of corticosterone on BDNF expression and mood behaviours in mice. Physiology and Behavior, 247(113721), 113721-1-113721-9.
DOI Scopus31 WoS32 Europe PMC23
2022 Xiong, L. L., Xue, L. L., Du, R. L., Zhou, H. L., Tan, Y. X., Ma, Z., . . . Wang, T. H. (2022). Corrigendum: Vi4-miR-185-5p-Igfbp3 Network Protects the Brain From Neonatal Hypoxic Ischemic Injury via Promoting Neuron Survival and Suppressing the Cell Apoptosis (Front. Cell Dev. Biol., (2020), 8, (529544), 10.3389/fcell.2020.529544). Frontiers in Cell and Developmental Biology, 10, 2 pages.
DOI
2022 Xiong, J., Deng, I., Kelliny, S., Lin, L., Bobrovskaya, L., & Zhou, X. F. (2022). Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice. Metabolic Brain Disease, 37(6), 1941-1957.
DOI Scopus21 WoS20 Europe PMC20
2022 Deng, I., Garg, S., Zhou, X. F., & a Bobrovskaya, L. (2022). The effects of novel formulations of edaravone and curcumin in the mouse intrastriatal lipopolysaccharide model of Parkinson's disease. Frontiers in bioscience (Scholar edition), 14(2), 1-17.
DOI Scopus4 Europe PMC3
2022 Daraghmeh, D. N., Moghaddami, M., Bobrovskaya, L., Proudman, S. M., & Wiese, M. D. (2022). Quantitation of methotrexate polyglutamates in human whole blood, erythrocytes and leukocytes collected via venepuncture and volumetric absorptive micro-sampling: a green LC-MS/MS-based method. Analytical And Bioanalytical Chemistry, 414(20), 6029-6046.
DOI Scopus19 WoS19 Europe PMC13
2022 Herselman, M. F., Bailey, S., Deo, P., Zhou, X. -F., Gunn, K. M., & Bobrovskaya, L. (2022). The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial.. Nutrients, 14(22), 4776.
DOI Scopus14 WoS12 Europe PMC8
2022 Deng, I., & Bobrovskaya, L. (2022). Lipopolysaccharide mouse models for Parkinson's disease research: a critical appraisal. Neural Regeneration Research, 17(11), 2413-2417.
DOI Scopus13 WoS12 Europe PMC8
2021 Kelliny, S., Bobrovskaya, L., Zhou, X. F., & Upton, R. (2021). Pharmacokinetic modelling of human recombinant protein, p75ECD-Fc: a novel therapeutic approach for treatment of Alzheimer’s disease, in serum and tissue of Sprague Dawley rats. European Journal of Drug Metabolism and Pharmacokinetics, 46(2), 235-248.
DOI Scopus2 WoS2 Europe PMC2
2021 Zidan, A. A., Perkins, G., Al Hawwas, M., Elhossiny, A., Yang, J., Bobrovskaya, L., . . . Hurtado, P. R. (2021). Urine stem cells are equipped to provide B cell survival signals. Stem Cells, 39(6), 803-818.
DOI Scopus7 WoS6 Europe PMC7
2021 Xiong, L. L., Tan, Y. X., Du, R. L., Peng, Y., Xue, L. L., Liu, J., . . . Zhou, X. F. (2021). Effect of sutellarin on neurogenesis in neonatal hypoxia-ischemia rat model: potential mechanisms of action. American Journal of Chinese Medicine, 49(3), 677-703.
DOI Scopus10 WoS7 Europe PMC9
2021 Kelliny, S., Lin, L., Deng, I., Xiong, J., Zhou, F., Al-Hawwas, M., . . . Zhou, X. F. (2021). A new approach to model sporadic Alzheimer’s disease by intracerebroventricular streptozotocin injection in APP/PS1 mice. Molecular Neurobiology, 58(8), 3692-3711.
DOI Scopus17 WoS15 Europe PMC17
2021 Deng, I., Wiese, M. D., Zhou, X. F., & Bobrovskaya, L. (2021). The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice. NeuroToxicology, 85, 254-264.
DOI Scopus17 WoS14 Europe PMC11
2021 Deng, I., Corrigan, F., Garg, S., Zhou, X. F., & Bobrovskaya, L. (2021). Further characterization of intrastriatal lipopolysaccharide model of parkinson’s disease in c57bl/6 mice. International Journal of Molecular Sciences, 22(14), 20 pages.
DOI Scopus13 WoS11 Europe PMC10
2021 Xiong, L. L., Tan, Y. X., Du, R. L., Peng, Y., Xue, L. L., Liu, J., . . . Zhou, X. F. (2021). Erratum: Effect of scutellarin on neurogenesis in neonatal hypoxia-ischemia rat model: Potential mechanisms of action (American Journal of Chinese Medicine (2021) 49:3 (677-703) DOI: 10.1142/s0192415x21500312). American Journal of Chinese Medicine, 49(7), 1791-1792.
DOI
2021 Kelliny, S., Xiong, J., Bobrovskaya, L., & Zhou, X. F. (2021). Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia. Neurotoxicity Research, 39(6), 1689-1707.
DOI Scopus4 WoS4 Europe PMC3
2021 Liu, D., Bobrovskaya, L., & Zhou, X. F. (2021). Cell therapy for neurological disorders: the perspective of promising cells. Biology, 10(11, article no. 1142), 1-23.
DOI Scopus18 WoS13 Europe PMC12
2021 Xiong, L. L., Tan, Y. X., Du, R. L., Peng, Y., Xue, L. L., Liu, J., . . . Zhou, X. F. (2021). ERRATUM: Effect of Scutellarin on Neurogenesis in Neonatal Hypoxia-Ischemia Rat Model: Potential Mechanisms of Action. The American journal of Chinese medicine, 49(8), 2053-2055.
DOI
2021 Lin, L., Zhou, X. F., & Bobrovskaya, L. (2021). Blockage of p75NTR ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress. Behavioural Brain Research, 396(112905), 1-5.
DOI Scopus10 WoS9 Europe PMC7
2021 Lin, L., Fu, X. Y., Zhou, X. F., Liu, D., Bobrovskaya, L., & Zhou, L. (2021). Analysis of blood mature BDNF and proBDNF in mood disorders with specific ELISA assays. Journal of Psychiatric Research, 133, 166-173.
DOI Scopus31 WoS27 Europe PMC25
2021 Zidan, A. A., Al Hawwas, M., Perkins, G. B., Mourad, G. M., Stapledon, C. J. M., Bobrovskaya, L., . . . Hurtado, P. R. (2021). Characterization of urine stem cell-derived extracellular vesicles reveals B cell stimulating cargo. International Journal of Molecular Sciences, 22(1), 1-21.
DOI Scopus21 WoS19 Europe PMC18
2020 Liu, D., Rychkov, G., Al-Hawwas, M., Manaph, N. P. A., Zhou, F., Bobrovskaya, L., . . . Zhou, X. -F. (2020). Conversion of human urine-derived cells into neuron-like cells by small molecules. Molecular Biology Reports, 47(4), 1-10.
DOI Scopus17 WoS18 Europe PMC16
2020 Li, H., Lin, L. Y., Zhang, Y., Lim, Y., Rahman, M., Beck, A., . . . Zhou, X. F. (2020). Pro-BDNF knockout causes abnormal motor behaviours and early death in mice. Neuroscience, 438, 145-157.
DOI Scopus14 WoS12 Europe PMC10
2020 Rahman, M., Luo, H., Bobrovskaya, L., & Zhou, X. F. (2020). Neuroprotective effects of anti-proBDNF in a rat photothrombotic ischemic model. Neuroscience, 446, 261-270.
DOI Scopus3 WoS3 Europe PMC3
2020 Lin, L. Y., Kelliny, S., Liu, L. C., Al-Hawwas, M., Zhou, X. F., & Bobrovskaya, L. (2020). Peripheral proBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice. Neurotoxicity Research, 38(3), 626-639.
DOI Scopus7 WoS7 Europe PMC7
2020 Kelliny, S., Lam, H. Y., Parikh, A., Wang, Y. J., Bobrovskaya, L., Upton, R., & Zhou, X. F. (2020). Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer’s disease, in Sprague Dawley rats. Current Drug Metabolism, 21(3), 235-244.
DOI Scopus8 WoS7 Europe PMC7
2020 Liu, D., Pavathuparambil Abdul Manaph, N., Al Hawwas, M., Bobrovskaya, L., Xiong, L. L., & Zhou, X. F. (2020). Coating materials for neural stem/progenitor cell culture and differentiation. Stem Cells and Development, 29(8), 463-474.
DOI Scopus28 WoS27 Europe PMC21
2020 Xiong, L. L., Xue, L. L., Du, R. L., Zhou, H. L., Tan, Y. X., Ma, Z., . . . Wang, T. H. (2020). Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis. Frontiers in Cell and Developmental Biology, 8(529544), 1-18.
DOI Scopus30 WoS25 Europe PMC26
2020 Deng, I., Corrigan, F., Zhai, G., Zhou, X. -F., & Bobrovskaya, L. (2020). Lipopolysaccharide animal models of Parkinson's disease: Recent progress and relevance to clinical disease. Brain Behav Immun Health, 4(100060), 1-12.
DOI Scopus98 WoS85 Europe PMC63
2019 Luo, H. Y., Rahman, M., Bobrovskaya, L., & Zhou, X. F. (2019). The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke. Neurotoxicity Research, 36(1), 49-57.
DOI Scopus14 WoS11 Europe PMC10
2019 Lin, L. Y., Luo, S. Y., Al Hawwas, M., Herselman, M. F., Zhou, X. F., & Bobrovskaya, L. (2019). The long-term effects of ethanol and corticosterone on the mood-related behaviours and the balance between mature BDNF and proBDNF in mice. Journal of molecular neuroscience, 69(1), 60-68.
DOI Scopus17 WoS15 Europe PMC15
2019 Mañucat-Tan, N. B., Saadipour, K., Wang, Y. J., Bobrovskaya, L., & Zhou, X. F. (2019). Correction to: Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance (Molecular Neurobiology, (2019), 56, 2, (812-830), 10.1007/s12035-018-1106-9). Molecular Neurobiology, 56(2), 831-832.
DOI
2019 Johnson, M. E., Zhou, X. F., & Bobrovskaya, L. (2019). The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson's disease. Journal of chemical neuroanatomy, 97, 23-32.
DOI Scopus17 WoS15 Europe PMC11
2019 Mañucat-Tan, N. B., Saadipour, K., Wang, Y. J., Bobrovskaya, L., & Zhou, X. F. (2019). Cellular trafficking of amyloid precursor protein in amyloidogenesis physiological and pathological significance. Molecular Neurobiology, 56(2), 812-830.
DOI Scopus28 WoS28 Europe PMC27
2019 Mañucat-Tan, N. B., Shen, L. L., Bobrovskaya, L., Al-hawwas, M., Zhou, F. H., Wang, Y. J., & Zhou, X. F. (2019). Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model. Aging, 11(17), 6762-6791.
DOI Scopus22 WoS20 Europe PMC17
2019 Zhang, Y., Rauf Khan, A., Fu, M., Zhai, Y., Ji, J., Bobrovskaya, L., & Zhai, G. (2019). Advances in curcumin-loaded nanopreparations: improving bioavailability and overcoming inherent drawbacks. Journal of drug targeting, 27(9), 917-931.
DOI Scopus49 WoS44 Europe PMC30
2019 Zhang, Z. B., Tan, Y. X., Zhao, Q., Xiong, L. L., Liu, J., Xu, F. F., . . . Wang, T. H. (2019). miRNA-7a-2-3p inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model. Frontiers in neuroscience, 13, article 16(JAN), 1-10.
DOI Scopus33 WoS30 Europe PMC26
2019 Shehadeh, J., Double, K. L., Murphy, K. E., Bobrovskaya, L., Reyes, S., Dunkley, P. R., . . . Dickson, P. W. (2019). Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease. Neurobiology of disease, 130(104524), 1-8.
DOI Scopus24 WoS19 Europe PMC16
2018 Ruan, C. S., Zeng, Y. Q., Guo, Y., Bobrovskaya, L., & Zhou, X. F. (2018). A pilot study in modeling mood disorders in mice by chronic tail-suspension stress. Neuropsychiatry, 8(5), 1586-1592.
DOI
2018 Senthilkumaran, M., & Bobrovskaya, L. (2018). The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF. Autonomic neuroscience: basic and clinical, 210, 76-80.
DOI Scopus10 WoS9 Europe PMC8
2018 Johnson, M. E., Stringer, A., & Bobrovskaya, L. (2018). Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease. NeuroToxicology, 65, 174-185.
DOI Scopus105 WoS88 Europe PMC89
2018 Senthilkumaran, M., Bobrovskaya, L., Verberne, A. J. M., & Llewellyn-Smith, I. J. (2018). Insulin-responsive autonomic neurons in rat medulla oblongata. Journal of Comparative Neurology, 526(16), 2665-2682.
DOI Scopus8 WoS8 Europe PMC9
2018 Lim, Y., Wu, L., Chen, S., Sun, Y., Vijayaraj, S., Yang, M., . . . Zhou, X. (2018). HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons. Molecular Neurobiology, 55(3), 1815-1830.
DOI Scopus26 WoS23 Europe PMC21
2018 Ruan, C. S., Liu, J., Yang, M., Saadipour, K., Zeng, Y. Q., Liao, H., . . . Zhou, X. F. (2018). Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP. Experimental Neurology, 299(Pt A), 75-85.
DOI Scopus16 WoS16 Europe PMC14
2018 Johnson, M. E., Salvatore, M. F., Maiolo, S. A., & Bobrovskaya, L. (2018). Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson's progression: Evidence from clinical studies and neurotoxin models. Progress in Neurobiology, 165-167, 1-25.
DOI Scopus45 WoS41 Europe PMC37
2018 Maiolo, S., Fan, P., & Bobrovskaya, L. (2018). Bioactive constituents from cinnamon, hemp seed and polygonum cuspidatum protect against H2O2but not rotenone toxicity in a cellularmodel of Parkinson's disease. Journal of Traditional and Complementary Medicine, 8(3), 420-427.
DOI Scopus24 Europe PMC12
2018 Pavathuparambil Abdul Manaph, N., Al-Hawaas, M., Bobrovskaya, L., Coates, P. T., & Zhou, X. F. (2018). Urine-derived cells for human cell therapy. Stem Cell Research and Therapy, 9(1), 189-1-189-12.
DOI Scopus74 WoS67 Europe PMC58
2018 Manaph, N., Al-Hawwas, M., Bobrovskaya, L., Coates, P., & Zhou, X. (2018). Correction to: Urine-derived cells for human cell therapy (Stem Cell Res Ther. (2018) 9 (189) DOI: 10.1186/s13287-018-0932-z). Stem Cell Research and Therapy, 9(1), 222.
DOI Scopus6 WoS6 Europe PMC5
2018 Rahman, M., Luo, H., Sims, N. R., Bobrovskaya, L., & Zhou, X. F. (2018). Investigation of mature BDNF and proBDNF signaling in a rat photothrombotic ischemic model. Neurochemical Research, 43(3), 637-649.
DOI Scopus29 WoS27 Europe PMC24
2018 Saadipour, K., Mañucat-Tan, N. B., Lim, Y., Keating, D. J., Smith, K. S., Zhong, J. H., . . . Zhou, X. F. (2018). p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. Journal of Neurochemistry, 144(3), 302-317.
DOI Scopus28 WoS26 Europe PMC27
2018 Shen, L. L., Mañucat-Tan, N. B., Gao, S. H., Li, W. W., Zeng, F., Zhu, C., . . . Wang, Y. J. (2018). The proNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau. Molecular Psychiatry, 23(8), 1813-1824.
DOI Scopus42 WoS38 Europe PMC33
2018 Xiong, L. L., Xiao, Q. X., AI Hawwas, M., Bobrovskaya, L., Liu, D. H., & Zhou, X. F. (2018). Treatment of hypoxic-ischemic encephalopathy in neonates: a systematic review and meta-analysis. Ibrain, 4(4), 52-61.
DOI Scopus1
2017 Barker, T., Bobrovskaya, L., Howarth, G., & Whittaker, A. (2017). Female rats display fewer optimistic responses in a judgment bias test in the absence of a physiological stress response. Physiology and Behavior, 173, 124-131.
DOI Scopus16 WoS14 Europe PMC9
2017 Li, J. Y., Liu, J., Manaph, N. P. A., Bobrovskaya, L., & Zhou, X. F. (2017). ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells. Brain Research, 1668, 46-55.
DOI Scopus50 WoS47 Europe PMC37
2017 Luo, Q., Yan, X., Bobrovskaya, L., Ji, M., Yuan, H., Lou, H., & Fan, P. (2017). Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Molecular and cellular biochemistry, 428(1), 129-137.
DOI Scopus85 WoS77 Europe PMC52
2017 Ruan, C. S., Bobrovskaya, L., & Zhou, X. F. (2017). Female wild-type and APP/PS1 transgenic mice deficient in Sort1 are prone to anxiety-like behavior at older ages. Neuropsychiatry, 7(6), 1047-1052.
DOI
2016 Ruan, C. S., Bobrovskaya, L., & Zhou, X. F. (2016). Absence of sortilin increases the convergence of app and bace1 in soma. Alzheimer's and dementia, 12(7), 455.
DOI
2016 Senthilkumaran, M., Johnson, M. E., & Bobrovskaya, L. (2016). The effects of insulin-induced hypoglycaemia on tyrosine hydroxylase phosphorylation in rat brain and adrenal gland. Neurochemical Research, 41(7), 1612-1624.
DOI Scopus19 WoS18 Europe PMC17
2016 Whittaker, A. L., Bajic, J. E., Bobrovskaya, L., Hutchinson, M. R., & Howarth, G. S. (2016). 200 Chemotherapy induces intestinal inflammation and central changes which are modified by analgesics via neuro-immune mechanisms. Gastroenterology, 150(4), 52.
DOI
2016 Zhou, L., Liu, D., Zeng, Y. Q., Wang, T. H., Tian, C. F., Liao, H., . . . Zhou, X. F. (2016). ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress. Neuropsychopharmacology, 41(12), 2882-2892.
DOI Scopus103 WoS99 Europe PMC81
2016 Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2016). Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies. International Journal of Endocrinology, 2016(article no. 9801640), 13 pages.
DOI Scopus17 WoS17 Europe PMC16
2016 Ruan, C. S., Yang, C. R., Li, J. Y., Luo, H. Y., Bobrovskaya, L., & Zhou, X. F. (2016). Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior. Experimental Neurology, 281, 99-108.
DOI Scopus23 WoS22 Europe PMC20
2015 Johnson, M. E., Lim, Y., Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2015). Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. Journal of Chemical Neuroanatomy, 70, 33-41.
DOI Scopus32 WoS27 Europe PMC24
2015 Wang, K., Brooks, D., Summers-Pearce, B., Bobrovskaya, L., Tosh, D., Duffield, J., . . . Morrison, J. (2015). Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life. Physiological Reports, 3(2), e12270-1-e12270-16.
DOI Scopus23 WoS20 Europe PMC19
2015 Johnson, M. E., & Bobrovskaya, L. (2015). An update on the rotenone models of Parkinson's disease : their ability to reproduce the features of clinical disease and model gene-environment interactions. Neurotoxicology, 46, 101-116.
DOI Scopus281 WoS266 Europe PMC224
2014 Ong, L. K., Guan, L., Damanhuri, H., Goodchild, A. K., Bobrovskaya, L., Dickson, P. W., & Dunkley, P. R. (2014). Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. Journal of neurochemistry, 128(4), 547-560.
DOI Scopus34 WoS34 Europe PMC32
2014 Johnson, J., Rolan, P., Johnson, M., Bobrovskaya, L., Williams, D., Johnson, K., . . . Hutchinson, M. (2014). Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry, 4(e482), e482-1-e482-9.
DOI Scopus34 WoS32 Europe PMC32
2013 Bobrovskaya, L., Beard, D., Bondarenko, E., Beig, M. I., Jobling, P., Walker, F. R., . . . Nalivaiko, E. (2013). Does exposure to chronic stress influence blood pressure in rats?. Autonomic neuroscience, 177(2), 217-223.
DOI Scopus20 WoS17 Europe PMC16
2013 Bobrovskaya, L., Maniam, J., Ong, L. K., Dunkley, P. R., & Morris, M. J. (2013). Early life stress and post-weaning high fat diet alter tyrosine hydroxylase regulation and AT1 receptor expression in the adrenal gland in a sex dependent manner. Neurochemical research, 38(4), 826-833.
DOI Scopus12 WoS11 Europe PMC11
2012 Sominsky, L., Meehan, C. L., Walker, A. K., Bobrovskaya, L., McLaughlin, E. A., & Hodgson, D. M. (2012). Neonatal immune challenge alters reproductive development in the female rat. Hormones and behavior, 62(3), 345-355.
DOI Scopus54 WoS49 Europe PMC38
2012 Wang, K., Brooks, D., Pearce, B., Bobrovskaya, L., Duffield, J., McMillen, C., & Morrison, J. (2012). Impact with low birth weight on the expression of the renin-angiotensin system, factors which regulate autophagy, fibrosis and capillary density in the heart during early postnatal life. Journal of hypertension, 30(Supplement 1), 76.
DOI
2012 Damanhuri, H. A., Burke, P. G. R., Ong, L. K., Bobrovskaya, L., Dickson, P. W., Dunkley, P. R., & Goodchild, A. K. (2012). Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions : a marker of activation following acute hypotension and glucoprivation. PLoS one, 7(11), article no. e50535.
DOI Scopus31 WoS31 Europe PMC28
2011 Aumann, T. D., Egan, K., Lim, J., Boon, W. C., Bye, C. R., Chua, H. K., . . . Horne, M. K. (2011). Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons. Journal of neurochemistry, 116(4), 646-658.
DOI Scopus45 WoS43 Europe PMC39
2011 Ong, L. K., Bobrovskaya, L., Walker, F. R., Day, T. A., Dickson, P., & Dunkley, P. (2011). The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland. Neurochemical research, 36(1), 27-33.
DOI Scopus15 WoS14 Europe PMC13
2011 Ong, L. K., Guan, L., Stutz, B., Dickson, P., Dunkley, P., & Bobrovskaya, L. (2011). The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland. Neuroscience, 192, 20-27.
DOI Scopus23 WoS21 Europe PMC20
2010 Franco, J., Posser, T., Gordon, S., Bobrovskaya, L., Schneider, J., Farina, M., . . . Dunkley, P. (2010). Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults. Toxicological sciences, 113(1), 150-157.
DOI Scopus20 WoS18 Europe PMC15
2010 Bobrovskaya, L., Damanhuri, H. A., Ong, L. K., Schneider, J. J., Dickson, P. W., Dickson, P. R., & Goodchild, A. K. (2010). Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: an in vivo analysis. Neurochemistry international, 57(2), 162-167.
DOI Scopus24 WoS22 Europe PMC19
2009 Posser, T., Franco, J. L., Bobrovskaya, L., Leal, R. B., Dickson, P. W., & Dunkley, P. R. (2009). Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells. Journal of neurochemistry, 110(3), 848-856.
DOI Scopus37 WoS35 Europe PMC29
2009 Gordon, S. L., Bobrovskaya, L., Dunkley, P. R., & Dickson, P. W. (2009). Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ : isoform 2 is not phosphorylated at Ser35. Biochimica et biophysica acta : molecular cell research, 1793(12), 1860-1867.
DOI Scopus45 WoS42 Europe PMC34
2007 Lehmann, I. T., Bobrovskaya, L., Gordon, S. L., Dunkley, P. R., & Dickson, P. W. (2007). Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. Journal of Biological Chemistry, 281(26), 17644-17651.
DOI Scopus75 WoS75 Europe PMC60
2007 Bobrovskaya, L., Gilligan, C., Bolster, E., Flaherty, J., Dickson, P., & Dunkley, P. (2007). Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis. Journal of neurochemistry, 100(2), 479-489.
DOI Scopus69 WoS66 Europe PMC59
2007 Bobrovskaya, L., Gelain, D., Gilligan, C., Dickson, P., & Dunkley, P. (2007). PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40. Cellular signalling, 19(6), 1141-1149.
DOI Scopus48 WoS48 Europe PMC37
2004 Dunkley, P. R., Bobrovskaya, L., Graham, M. E., Von Nagy-Felsobuki, E. I., & Dickson, P. W. (2004). Tyrosine hydroxylase phosphorylation: Regulation and consequences. Journal of Neurochemistry, 91(5), 1025-1043.
DOI Scopus411 WoS402 Europe PMC346
2004 Bobrovskaya, L., Dunkley, P. R., & Dickson, P. W. (2004). Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. Journal of Neurochemistry, 90(4), 857-864.
DOI Scopus63 WoS63 Europe PMC51
2004 Ma, F. Y., Grattan, D. R., Bobrovskaya, L., Dunkley, P. R., & Bunn, S. J. (2004). Angiotensin II regulates tyrosine hydroxylase activity and mRNA expression in rat mediobasal hypothalamic cultures: The role of specific protein kinases. Journal of Neurochemistry, 90(2), 431-441.
DOI Scopus22 WoS23 Europe PMC22
2004 Leal, R. B., Frizzo, J. K., Tramontina, F., Fieuw-Makaroff, S., Bobrovskaya, L., Dunkley, P. R., & Gonçalves, C. A. (2004). S100B protein stimulates calcineurin activity. Neuroreport, 15(2), 317-320.
DOI Scopus17 WoS16 Europe PMC13
2002 Leal, R. B., Cordova, F. M., Herd, L., Bobrovskaya, L., & Dunkley, P. R. (2002). Lead-stimulated p38MAPK-dependent Hsp27 phosphorylation. Toxicology and Applied Pharmacology, 178(1), 44-51.
DOI Scopus63 WoS63 Europe PMC54
2001 Bobrovskaya, L., Odell, A., Leal, R. B., & Dunkley, P. R. (2001). Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: The role of MAPKs after angiotensin II stimulation. Journal of Neurochemistry, 78(3), 490-498.
DOI Scopus37 WoS34 Europe PMC33
1999 Cheah, T. B., Bobrovskaya, L., Gonçalves, C. A., Hall, A., Elliot, R., Lengyel, I., . . . Dunkley, P. R. (1999). Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells. Journal of Neuroscience Methods, 87(2), 167-174.
DOI Scopus23 WoS23 Europe PMC20
1998 Bobrovskaya, L., Cheah, T. B., Bunn, S. J., & Dunkley, P. R. (1998). Tyrosine hydroxylase in bovine adrenal chromaffin cells: Angiotensin II- stimulated activity and phosphorylation of Ser19 Ser31 and Ser40. Journal of Neurochemistry, 70(6), 2565-2573.
DOI Scopus33 WoS34 Europe PMC27

Year Citation
2019 Llewellyn-Smith, I. J., Senthilkumaran, M., Spradley, F., Etelvino, G. M., Bobrovskaya, L., Carrive, P., . . . Verberne, A. J. M. (2019). Functional Topography in the Rat Rostral Ventrolateral Medulla (RVLM): Distribution of Cl Neurons that Respond to Cardiovascular versus Metabolic Stimuli. In FASEB JOURNAL Vol. 33 (pp. 2 pages). FL, Orlando: WILEY.
2018 Llewellyn-Smith, I. J., Senthilkumaran, M., Verberne, A. J. M., & Bobrovskaya, L. (2018). Effects of Recurrent Hypoglycaemia on the Activation of Insulin-Responsive Medullary and Spinal Neurons Controlling Adrenaline Release. In FASEB JOURNAL Vol. 32 (pp. 2 pages). Amer Assoc Anatomists, San Diego, CA: FEDERATION AMER SOC EXP BIOL.
2015 Senthilkumaran, M., Johnson, M., & Bobrovskaya, L. (2015). The effects of insulin induced hypoglycaemia on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 172-173). AUSTRALIA, Cairns: WILEY-BLACKWELL.
2014 Dickson, P., Shehadeh, J., Double, K., Bobrovskaya, L., Reyes, S., Dunkley, P., & Halliday, G. (2014). Analysis of tyrosine hydroxylase isoforms and phosphorylation in Parkinson's Disease. In L. E. Eiden (Ed.), Catecholamine research in the 21st century: abstracts and graphical abstracts (pp. 15). US: Elsevier.
DOI
2012 Ong, L., Guan, L., Bobrovskaya, L., Dickson, P., & Dunkley, P. (2012). Neurobiological consequences of acute footshock stress. In JOURNAL OF NEUROCHEMISTRY Vol. 123 (pp. 124-125). WILEY-BLACKWELL.
2011 Ong, L. K., Sominsky, L., Walker, A. K., Hodgson, D. M., Goodchild, A. K., Bobrovskaya, L., . . . Dunkley, P. R. (2011). SUSTAINED PHOSPHORYLATION OF TYROSINE HYDROXYLASE AT SERINE 40 <i>IN VIVO</i>. In JOURNAL OF NEUROCHEMISTRY Vol. 118 (pp. 77). WILEY.
2011 Damanhuri, H., Bobrovskaya, L., Dunkley, P., & Goodchild, A. (2011). Effect of barodenervation on tyrosine hydroxylase phosphorylation in rat brain following hypotension. In FASEB JOURNAL Vol. 25 (pp. 1 page). DC, Washington: FEDERATION AMER SOC EXP BIOL.
2010 Ong, L. K., Guan, L., Stutz, B., Dickson, P. W., Dunkley, P., & Bobrovskaya, L. (2010). TYROSINE HYDROXYLASE PHOSPHORYLATION IN RESPONSE TO FOOTSHOCK AND RESTRAINT STRESS. In JOURNAL OF NEUROCHEMISTRY Vol. 115 (pp. 77). WILEY-BLACKWELL PUBLISHING, INC.
2010 Damanhuri, H., Bobrovskaya, L., Dunkley, P. R., & Goodchild, A. K. (2010). EFFECT OF GLUCOPRIVATION AND HYPOTENSION ON TYROSINE HYDROXYLASE PHOSPHORYLATION IN DIFFERENT CATECHOLAMINE CELL GROUPS IN THE RAT BRAINSTEM. In JOURNAL OF NEUROCHEMISTRY Vol. 115 (pp. 14). WILEY-BLACKWELL PUBLISHING, INC.
2010 Nalivaiko, E., Beard, D., Bondarenko, E., Beig, M. I., Jobling, P., Walker, F. R., . . . Bobrovskaya, L. (2010). CHRONIC FOOTSHOCK STRESS CAUSES ENDURING CHANGES IN CIRCADIAN RHYTHMS, WITHOUT PROVOKING HYPERTENSION IN RATS. In FASEB JOURNAL Vol. 24 (pp. 1 page). FEDERATION AMER SOC EXP BIOL.
2009 Ong, L. K., Bobrovskaya, L., Walker, F. R., Day, T. A., Dickson, P. W., & Dunkley, P. R. (2009). THE EFFECT OF SOCIAL CONFLICT ON TYROSINE HYDROXYLASE PHOSPHORYLATION IN CATECHOLAMINE-PRODUCING CELLS FROM SPRAGUE-DAWLEY RATS. In JOURNAL OF NEUROCHEMISTRY Vol. 110 (pp. 169). SOUTH KOREA, Busan: WILEY-BLACKWELL PUBLISHING, INC.
2009 Gordon, S. L., Bobrovskaya, L., Dunkley, P. R., & Dickson, P. W. (2009). DIFFERENTIAL REGULATION OF THE TWO MAJOR ISOFORMS OF HUMAN TYROSINE HYDROXYLASE <i>IN SITU</i>. In JOURNAL OF NEUROCHEMISTRY Vol. 110 (pp. 167-168). SOUTH KOREA, Busan: WILEY-BLACKWELL PUBLISHING, INC.
2009 Dickson, P. W., Shehadeh, J., Double, K. L., Bobrovskaya, L., Reyes, S., Dunkley, P. R., & Halliday, G. M. (2009). DISTRIBUTION OF TYROSINE HYDROXYLASE ISOFORMS IN THE HUMAN BRAIN. In JOURNAL OF NEUROCHEMISTRY Vol. 110 (pp. 118). SOUTH KOREA, Busan: WILEY-BLACKWELL PUBLISHING, INC.
2005 Lehmann, I. T., Bobrovskaya, L., Dunkley, P. R., & Dickson, P. W. (2005). Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation. In JOURNAL OF NEUROCHEMISTRY Vol. 94 (pp. 204). AUSTRIA, Innsbruck: WILEY-BLACKWELL PUBLISHING, INC.
2005 Dunkley, P. R., Bobrovskaya, L., Gilligan, C., Soster, E., & Dickson, P. W. (2005). Sustained phosphorylation of tyrosine hydroxylase at Ser40. In JOURNAL OF NEUROCHEMISTRY Vol. 94 (pp. 203). AUSTRIA, Innsbruck: WILEY-BLACKWELL PUBLISHING, INC.
2004 Dunkley, P., Bobrovskaya, L., Dickson, P., Rose, J., & Lehmann, I. (2004). Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells. In JOURNAL OF NEUROCHEMISTRY Vol. 88 (pp. 82). PEOPLES R CHINA, Hong Kong: BLACKWELL PUBLISHING LTD.
2003 Bobrovskaya, L., Dunkley, P. R., & Dickson, P. W. (2003). Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. In JOURNAL OF NEUROCHEMISTRY Vol. 87 (pp. 122). PEOPLES R CHINA, WANCHAI: BLACKWELL PUBLISHING LTD.
2001 Bobrovskaya, L., Odell, A., & Dunkley, P. R. (2001). Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the involvement of MAPKs after angiotensin II stimulation. In JOURNAL OF NEUROCHEMISTRY Vol. 78 (pp. 146). BLACKWELL SCIENCE LTD.
WoS2
2000 Bobrovskaya, L., Cheah, T. B., & Dunkley, P. R. (2000). Angiotensin II-stimulated tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells. In JOURNAL OF NEUROCHEMISTRY Vol. 74 (pp. S38). LIPPINCOTT WILLIAMS & WILKINS.
1999 Bobrovskaya, L., Dickson, P., Cheah, T. B., & Dunkley, P. R. (1999). The role of mitogen-activated protein kinase in tyrosine hydroxylase phosphorylation.. In JOURNAL OF NEUROCHEMISTRY Vol. 73 (pp. S34). LIPPINCOTT WILLIAMS & WILKINS.
1999 Bobrovskaya, L., Cheah, T. B., & Dunkley, P. R. (1999). Phorbol ester-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells. In JOURNAL OF NEUROCHEMISTRY Vol. 72 (pp. S25). LIPPINCOTT WILLIAMS & WILKINS.
1998 Bobrovskaya, L., Cheah, T. B., Bunn, S. J., & Dunkley, P. R. (1998). Angiotensin II-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells. In JOURNAL OF NEUROCHEMISTRY Vol. 71 (pp. S60). LIPPINCOTT WILLIAMS & WILKINS.

  • Prevalence of psychotropic polypharmacy and its chronic health implications in South Australian prisons, South Australian Prison Health Service, 02/02/2024 - 31/12/2027

  • PiezoSleep Mouse Behavioural Tracking System to Investigate the role of sleep in neurological disorders., Neurosurgical Research Foundation, 04/07/2024 - 31/12/2026

  • Characterization of beta cell-like cells coverted from human urine stem cells, Channel 7 Children's Research Foundation of SA, 01/01/2018 - 31/12/2018

Courses I teach

  • BIOL 3006 Chemical and Molecular Pathology (2025)
  • HLTH 1025 Health and Society (2025)
  • MEDI 4001 Clinical Biochemistry (2025)
  • BIOL 3006 Chemical and Molecular Pathology (2024)
  • MEDI 4001 Clinical Biochemistry (2024)

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Novel neurotherapeutics for the treatment of Parkinson's disease Doctor of Philosophy Doctorate Full Time Rasha Abu Thawabeh
2023 Co-Supervisor From solvent selection to tunable polymer microstructure: multi-parametric optimisation of in situ forming implants Doctor of Philosophy Doctorate Full Time Miss Alaa Yosf Bazeed
2023 Principal Supervisor Bridging the Sex and Gender Gap in Parkinson's disease Research Doctor of Philosophy Doctorate Full Time Miss Tahnee Thatcher
2023 Co-Supervisor Psychotropic pharmacotherapy and its chronic health implications for people in custody in South Australian prisons Doctor of Philosophy Doctorate Full Time Mr Joel William Moore
2021 Principal Supervisor Discovering the Roles of Orexins in Parkinson's disease Doctor of Philosophy Doctorate Full Time Ms Alisha Braun

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