Yoon Lim

Dr Yoon Lim

Research Fellow

Centre for Cancer Biology

College of Health


 Dr Yoon Lim is Research Fellow at the Centre for Cancer Biology (CCB), UniSA and SA Pathology. Yoon has over 11 years of experience in cell death in neurobiology and cancer biology.  Yoon completed his PhD in Neuroscience in 2016 (University of South Australia). Yoon’s PhD project focused on the signalling mechanisms of neurotrophins and their importance in neuronal survival, proliferation, and neurological disorders, including glioma, resulting in 17 primary research articles (3 as first author).   Before his PhD, Yoon worked for a biotech company in South Korea (2000 – 2007). Yoon discovered several diagnostic marker candidates for autoimmune diseases and cancer and developed a novel system for detecting residual antibiotics in whole milk that was widely recognised and sold to several major dairy companies in South Korea. Since Oct 2016, Yoon has been working as a post-doctoral researcher in cell death and cancer biology. He has been working with internal and external collaborators under the mentorship of Prof Sharad Kumar. He spent the last 6 years to understand how the cell death protease, caspase-2, is regulated in response to replicative stress in tumour suppression. His projects led to several seminal findings providing new mechanistic insights into the regulation of caspase-2 activation in tumour suppression. The contribution of his studies to the cell death field was recognised with the ANZSCDB Early Researcher Award in 2020.  Yoon has authored 34 journal articles (9 first or corresponding authors) which have attracted over 1450 citations, and his h-index is 23. He has presented at over 25 national and international conferences and has organised several national/local/institutional scientific meetings. Yoon is currently co-supervising three students (PhD, Masters and Honours).  

Year Citation
2025 Shabbar, M., Manning, J., Lim, Y., Shah, S., Sinha, D., Nikolic, A., . . . Kumar, S. (2025). Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination. Cell Death Discovery, 11(1, article no. 393), 1-11.
DOI Scopus1 WoS1
2025 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2025). NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury.. Cell Death Differ, online, 1-18.
DOI
2024 Nicolson, S., Manning, J. A., Lim, Y., Jiang, X., Kolze, E., Dayan, S., . . . Denton, D. (2024). The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy. Communications Biology, 7(1), 183-1-183-24.
DOI Scopus5 WoS3 Europe PMC4
2024 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2024). Caspase-2 protects against ferroptotic cell death. Cell Death and Disease, 15(3), 182-1-182-12.
DOI Scopus13 WoS12 Europe PMC11
2024 Vora, S., Andrew, A., Kumar, R. P., Nazareth, D., Bonfim-Melo, A., Lim, Y., . . . Gabrielli, B. (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death and Disease, 15(11, article no. 810), 810-1-810-9.
DOI Scopus6 WoS6 Europe PMC4
2022 Kumar, S., Dorstyn, L., & Lim, Y. (2022). The role of caspases as executioners of apoptosis. Biochemical Society Transactions, 50(1), 33-45.
DOI Scopus46 WoS42 Europe PMC37
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Tran, E. N. H., Campbell, D., Paton, S., . . . Hiwase, D. K. (2022). A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure. Leukemia, 36(11), 2678-2689.
DOI Scopus17 WoS17 Europe PMC17
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Campbell, D., Paton, S., Thompson-Peach, C. A. L., . . . Hiwase, D. (2022). Senolytic Therapy Can Reverse Senescent Bone Marrow Stroma of Therapy-Related Myeloid Neoplasm. Blood, 140(Supplement 1), 9755-9756.
DOI
2021 Lim, Y., De Bellis, D., Sandow, J. J., Capalbo, L., D'Avino, P. P., Murphy, J. M., . . . Kumar, S. (2021). Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.. Cell Death and Differentiation, 28(1), 349-366.
DOI Scopus25 WoS24 Europe PMC24
2021 Lim, Y., Dorstyn, L., & Kumar, S. (2021). The p53-caspase-2 axis in the cell cycle and DNA damage response. Experimental and Molecular Medicine, 53(4), 517-527.
DOI Scopus44 WoS40 Europe PMC36
2020 Li, H., Lin, L. Y., Zhang, Y., Lim, Y., Rahman, M., Beck, A., . . . Zhou, X. F. (2020). Pro-BDNF knockout causes abnormal motor behaviours and early death in mice. Neuroscience, 438, 145-157.
DOI Scopus14 WoS12 Europe PMC10
2019 Dorstyn, L., Hackett-Jones, E., Nikolic, A., Norris, M. D., Lim, Y., Toubia, J., . . . Kumar, S. (2019). Transcriptome profiling of caspase-2 deficient EµMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling. Cell Death and Disease, 10(2), 56-1-56-16.
DOI Scopus7 WoS6 Europe PMC6
2018 Saadipour, K., Mañucat-Tan, N. B., Lim, Y., Keating, D. J., Smith, K. S., Zhong, J. H., . . . Zhou, X. F. (2018). p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. Journal of Neurochemistry, 144(3), 302-317.
DOI Scopus28 WoS26 Europe PMC27
2018 Lim, Y., Wu, L., Chen, S., Sun, Y., Vijayaraj, S., Yang, M., . . . Zhou, X. (2018). HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons. Molecular Neurobiology, 55(3), 1815-1830.
DOI Scopus26 WoS23 Europe PMC21
2018 Lim, Y., De Bellis, D., Dorstyn, L., & Kumar, S. (2018). p53 accumulation following cytokinesis failure in the absence of caspase-2. Cell Death and Differentiation, 25(11), 2050-2052.
DOI Scopus11 WoS10 Europe PMC10
2017 Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., . . . Kumar, S. (2017). Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene, 36(19), 2704-2714.
DOI Scopus55 WoS52 Europe PMC50
2017 Lim, Y. Y., Rainey-Smith, S., Lim, Y., Laws, S. M., Gupta, V., Porter, T., . . . Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834.
DOI Scopus22 WoS18 Europe PMC18
2017 Mackenzie, K. D., Lim, Y., Duffield, M. D., Chataway, T., Zhou, X. F., & Keating, D. J. (2017). Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins. Cellular Signalling, 35, 176-187.
DOI Scopus30 WoS29 Europe PMC26
2016 Mackenzie, K. D., Lumsden, A. L., Guo, F., Duffield, M. D., Chataway, T., Lim, Y., . . . Keating, D. J. (2016). Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Journal of Neurochemistry, 138(5), 710-721.
DOI Scopus22 WoS22 Europe PMC21
2016 Han, Y. C., Lim, Y., Duffieldl, M. D., Li, H., Liu, J., Abdul Manaph, N. P., . . . Zhou, X. F. (2016). Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International, 2016(4304916), 4304916-1-4304916-11.
DOI Scopus51 WoS49 Europe PMC43
2015 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Wei Li, Z., . . . Zhou, X. (2015). Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncology Letters, 10(1), 223-227.
DOI Scopus32 WoS33 Europe PMC28
2015 Lim, Y., & Kumar, S. (2015). A single cut to pyroptosis. Oncotarget, 6(35), 36926-36927.
DOI Scopus25 WoS21 Europe PMC18
2015 Johnson, M. E., Lim, Y., Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2015). Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. Journal of Chemical Neuroanatomy, 70, 33-41.
DOI Scopus31 WoS27 Europe PMC23
2015 Lim, Y., Zhong, J. H., & Zhou, X. F. (2015). Development of mature BDNF-specific sandwich ELISA. Journal of Neurochemistry, 134(1), 75-85.
DOI Scopus49 WoS46 Europe PMC43
2013 Xiong, J., Zhou, L., Yang, M., Lim, Y., Zhu, Y., Fu, D., . . . Zhou, X. (2013). ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro-Oncology, 15(8), 990-1007.
DOI Scopus63 WoS55 Europe PMC49
2013 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., . . . Zhou, X. (2013). Mature BDNF promotes the growth of glioma cells in vitro. Oncology Reports, 30(6), 2719-2724.
DOI Scopus43 WoS38 Europe PMC35
2013 Zhou, L., Xiong, J., Lim, Y., Ruan, Y., Huang, C., Zhu, Y., . . . Zhou, X. F. (2013). Upregulation of blood proBDNF and its receptors in major depression. Journal of Affective Disorders, 150(3), 776-784.
DOI Scopus131 WoS121 Europe PMC107
2013 Saadipour, K., Yang, M., Lim, Y., Georgiou, K., Sun, Y., Keating, D., . . . Zhou, X. (2013). Amyloid beta₁–-₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway. Journal of Neurochemistry, 127(2), 152-162.
DOI Scopus47 WoS42 Europe PMC40
2013 Yang, M., Virassamy, B., Vijayaraj, S., Lim, Y., Saadipour, K., Wang, Y., . . . Zhou, X. (2013). The intracellular domain of sortilin interacts with Amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS One, 8(5), e63049-1-e63049-13.
DOI Scopus30 WoS28 Europe PMC28
2012 Yang, G., Yang, M., Lim, Y., Lu, J., Wang, T., Qi, J., . . . Zhou, X. (2012). Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. Journal of Neurochemistry, 122(5), 1010-1022.
DOI Scopus33 WoS33 Europe PMC28
2012 Sun, Y., Lim, Y., Li, F., Liu, S., Lu, J. J., Haberberger, R., . . . Zhou, X. F. (2012). ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS ONE, 7(4), 1-12.
DOI Scopus133 WoS95 Europe PMC111
2011 Xu, Z. Q., Sun, Y., Li, H. Y., Lim, Y., Zhong, J. H., & Zhou, X. F. (2011). Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. European journal of neuroscience, 33(8), 1376-1384.
DOI Scopus57 WoS53 Europe PMC47
2011 Yang, M., Lim, Y., Li, X., Zhong, J., & Zhou, X. (2011). Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. Journal of Biological Chemistry, 286(18), 16272-16284.
DOI Scopus67 WoS60 Europe PMC56
2011 Wang, Y., Wang, X., Lu, J., Li, Q., Gao, C., Liu, X., . . . Zhou, X. (2011). p75NTR regulates Aβ deposition by increasing Aβ production but inhibiting Aβ aggregation with its extracellular domain. Journal of Neuroscience, 31(6), 2292-2304.
DOI Scopus89 WoS82 Europe PMC75
2011 Wang, Y. J., Valadares, D., Sun, Y., Wang, X., Zhong, J. H., Liu, X. H., . . . Zhou, X. F. (2011). Erratum: Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism (Neurotoxicity Research (2010) 17 (257-267) DOI: 10.1007/s12640-009-9098-x). Neurotoxicity Research, 20(4), 402.
DOI WoS1
2010 WANG, Y., Valadares, D., Sun, Y., Wang, X., Zhong, J., Liu, X. H., . . . Zhou, X. F. (2010). Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotoxicity research, 17(3), 257-267.
DOI Scopus35 WoS34 Europe PMC27

Year Citation
2022 Kumar, S., Lim, Y., & Dorstyn, L. (2022). Tumor and aneuploidy suppression by caspase-2. In CANCER SCIENCE Vol. 113 (pp. 1 page). WILEY.

Year Citation
2023 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2023). Caspase-2 protects against ferroptotic cell death.
DOI

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