Elina Hypponen

Prof Elina Hypponen

Professor of Nutritional and Genetic Epidemiology

School of Public Health

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Available For Media Comment.


Professor Hyppönen is the Director of the Australian Centre for Precision Health at the University of South Australia. She was recruited to the UniSA as the Professor in Nutritional and Genetic Epidemiology in 2013, following 12 years at the University College London, Great Ormond Street Institute of Child Health (London, UK).She is a NHMRC Leadership (L2) Investigator and holds appointments as a Senior Principal Research Fellow at the South Australian Health and Medical Research Institute (SAHMRI) and as an Adjunct Professor in Epidemiology at the University of Tampere, Finland. Professor Hyppönen has an interdisciplinary academic background, with academic qualifications in epidemiology, medical statistics, nutrition and public health. Professor Hyppönen has a H-factor of 90, and her work has been cited over 51,000 times.  She has authored more than 230 high-profile refereed publications and several book chapters. She leads the Nutritional and Genetic Epidemiology group which has a focus on using genetic tools to inform on dietary and lifestyle guidelines for optimal health. She has a long-term research interest in life-course and intergenerational epidemiology, and an extensive track record in gene and risk factor discovery. Her current interests are related to methods of causal analyses, machine learning, and implementing systems epidemiology approaches to establish effective strategies for prediction and prevention of chronic diseases.  

Year Citation
2026 Pham, K., Mulugeta, A., Lumsden, A., & Hyppӧnen, E. (2026). A multivariable Mendelian randomization study of serum lipids and dementia risk within the UK Biobank. Journal of Nutritional Biochemistry, 148(110160), 1-9.
DOI
2025 Byrne, S., Hypponen, E., Benyamin, B., & Boyle, T. (2025). Greater adherence to lifestyle recommendations after cancer diagnosis is associated with lower mortality in the UK Biobank. Cancer Epidemiology, Biomarkers and Prevention, 34(5), 669-675.
DOI
2025 Stacey, D., Gaziano, L., Eldi, P., Toben, C., Benyamin, B., Lee, S. H., & Hyppönen, E. (2025). A Transcriptome-Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 198(6), 19-31.
DOI
2025 Amente, L. D., Mills, N. T., Le, T. D., Hyppönen, E., & Lee, S. H. (2025). A latent outcome variable approach for Mendelian randomization using the stochastic expectation maximization algorithm. Human Genetics, 144(5), 559-574.
DOI Scopus1 WoS1 Europe PMC1
2025 Mulugeta, A., Stacey, D., Lumsden, A. L., Madakkatel, I., Lee, S. H., Mäenpää, J., . . . Hyppönen, E. (2025). Protein markers of ovarian cancer and its subtypes: insights from proteome-wide Mendelian randomisation analysis. British Journal Of Cancer, 133(8), 1208-1217.
DOI
2025 Dewau, R., Byrne, S., Hyppönen, E., Lee, S. H., & Benyamin, B. (2025). Genetic and Environmental Contributions to Child Height in Low- and Middle-Income Countries. American Journal of Human Biology, 37(9), e70134.
DOI Europe PMC1
2025 Amente, L. D., Mills, N. T., Le, T. D., Hypponen, E., & Lee, S. H. (2025). Disentangling horizontal and vertical Pleiotropy in genetic correlation estimation: introducing the HVP model. Human Genetics, 144(8), 861-876.
DOI Europe PMC1
2025 Pham, K., Assefa Kassaw, N., Mulugeta, A., Zhou, A., & Hyppönen, E. (2025). Coffee and health outcomes: a systematic review of Mendelian randomisation studies. Nutrition Research Reviews, 38(2), 1006-1026.
DOI
2025 Hypponen, E., & Madakkatel, I. (2025). Response to Oka and Takefuji's correspondence on the article "Large-scale analysis to identify risk factors for ovarian cancer" by Madakkatel et al. International Journal Of Gynecological Cancer, 35(9, article no. 102000), 1.
DOI
2025 Lumsden, A. L., Mulugeta, A., & Hypponen, E. (2025). Dementia risk across distinct metabolic profiles in the UK Biobank. Geroscience, online, 1-25.
DOI
2025 Sutherland, J. P., Zhou, A., & Hyppönen, E. (2025). Vitamin D, C-reactive protein, and increased fall risk: a genetic epidemiological study. Nutrients, 17(1), 1-16.
DOI Scopus1 WoS1 Europe PMC1
2025 Yeshaw, Y., Madakkatel, I., Mulugeta, A., Lumsden, A., & Hypponen, E. (2025). Machine learning to discover factors predicting volume of white matter hyperintensities: insights from the UK Biobank. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(1, article no. e70090), 1-12.
DOI
2025 Hyppönen, E., Mulugeta, A., & Zhou, A. (2025). Reanalysis of the vitamin D and dementia association using the doubly-ranked nonlinear Mendelian randomization approach. The American Journal of Clinical Nutrition, 122(3), 894-897.
DOI Scopus1 WoS1
2025 Hypponen, E. (2025). Challenges with Mendelian randomization and its application to the study of vitamins. International Journal Of Epidemiology, 54(5, article no. dyaf165), 1-3.
DOI
2025 Zhou, A., & Hyppönen, E. (2025). A reanalysis of the bidirectional association between vitamin D and C-reactive protein using the doubly-ranked non-linear Mendelian randomization approach. International Journal of Epidemiology, 54(5, article no. dyaf166), 1-5.
DOI Scopus1 Europe PMC1
2024 Hypponen, E., Sutherland, J. P., & Zhou, A. (2024). Vitamin D deficiency increases mortality risk in the UK Biobank. Annals Of Internal Medicine, 177(12), 1743-1746.
DOI WoS2
2024 Kassaw, N. A., Zhou, A., Mulugeta, A., Lee, S. H., Burgess, S., & Hyppönen, E. (2024). Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study. International Journal of Epidemiology, 53(2), 1-8.
DOI Scopus15 WoS17 Europe PMC9
2024 Yeshaw, Y., Madakkatel, I., Mulugeta, A., Lumsden, A., & Hyppönen, E. (2024). Uncovering predictors of low hippocampal volume: evidence from a large-scale machine-learning-based study in the UK biobank. Neuroepidemiology, 58(5), 369-382.
DOI
2024 Eshetie, S., Choi, K. W., Hyppönen, E., Benyamin, B., & Lee, S. H. (2024). Integrative multi-omics analysis to gain new insights into COVID-19. Scientific Reports, 14(1), 14 pages.
DOI Scopus2 WoS2 Europe PMC1
2024 Momin, M. M., Zhou, X., Hyppönen, E., Benyamin, B., & Lee, S. H. (2024). Cross-ancestry genetic architecture and prediction for cholesterol traits. Human Genetics, 143(5), 635-648.
DOI Scopus1 WoS3 Europe PMC3
2024 Bradfeld, J. P., Kember, R. L., Ulrich, A., Balkhiyarova, Z., Alyass, A., Aris, I. M., . . . Hakonarson, H. (2024). Correction to: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes (Genome Biology, (2024), 25, 1, (22), 10.1186/s13059-023-03136-z). Genome Biology, 25(1), 129.
DOI
2024 Zhou, A., Selvanayagam, J. B., & Hypponen, E. (2024). Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk. EUROPEAN HEART JOURNAL, 45(26), 2305.
DOI WoS1
2024 Verhoef, E., Allegrini, A. G., Jansen, P. R., Lange, K., Hypponen, E., & St. Pourcain, B. (2024). Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with attention-deficit/hyperactivity disorder, literacy, and cognition-related traits. Biological Psychiatry, 95(9), 859-869.
DOI Scopus8 WoS8 Europe PMC13
2024 Madakkatel, I., & Hyppönen, E. (2024). LLpowershap: logistic loss-based automated Shapley values feature selection method. BMC Medical Research Methodology, 24(1, article no. 247), 1-14.
DOI Scopus1 WoS2
2024 Hyppönen, E., Sutherland, J. P., & Zhou, A. (2024). IN RESPONSE. Annals of Internal Medicine, 177(12), 1743-1746.
DOI Scopus5 WoS4 Europe PMC2
2024 Bradfield, J. P., Kember, R. L., Ulrich, A., Balkiyarova, Z., Hypponen, E., & Cousminer, D. L. (2024). Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. Genome biology, 25(22), 1-19.
DOI Scopus9 WoS8 Europe PMC10
2024 Dewau, R., Boomsma, A., Doyle, C., Byrne, S., Hyppönen, E., Lee, S. H., & Benyamin, B. (2024). Meta-Analysis of the Heritability of Childhood Height From 560 000 Pairs of Relatives Born Between 1929 and 2004. American Journal of Human Biology, 37(1), e24188-1-e24188-15.
DOI Scopus3 WoS3 Europe PMC3
2024 Jayasinghe, D., Momin, M. M., Beckmann, K., Hyppönen, E., Benyamin, B., & Lee, S. H. (2024). Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models. Genetic Epidemiology, 48(2), 85-100.
DOI Scopus7 WoS7 Europe PMC8
2024 Amente, L. D., Mills, N. T., Le, T. D., Hyppönen, E., & Lee, S. H. (2024). Unraveling phenotypic variance in metabolic syndrome through multi-omics. Human Genetics, 143(1), 35-47.
DOI Scopus4 WoS4 Europe PMC2
2024 Byrne, S., Boyle, T., Ahmed, M., Lee, S. H., Benyamin, B., & Hyppönen, E. (2024). Response to: Adherence to the World Cancer Research Fund lifestyle recommendations and incidence of prostate cancer in the UK Biobank.. Int J Epidemiol, 53(1), 1-2.
DOI Scopus1 WoS1 Europe PMC1
2024 Mulugeta, A., Lumsden, A., Madakkatel, I., Stacey, D., Lee, S. H., Mäenpää, J., . . . Hypponen, E. (2024). Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers. Cancer Medicine, 13(4, article no. e7051), 1-13.
DOI Scopus2 Europe PMC3
2024 Stacey, D., Benyamin, B., Lee, S. H., & Hyppönen, E. (2024). A metabolome-wide Mendelian randomization study identifies dysregulated arachidonic acid synthesis as a potential causal risk factor for bipolar disorder. Biological Psychiatry, 96(6), 455-462.
DOI Scopus16 WoS16 Europe PMC15
2024 Stacey, D., Suppiah, V., Benyamin, B., Lee, S. H., & Hyppönen, E. (2024). In-silico functional analyses identify TMPRSS15-mediated intestinal absorption of lithium as a modulator of lithium response in bipolar disorder. Journal of Affective Disorders, 358, 416-421.
DOI Scopus2 WoS2 Europe PMC2
2024 Madakkatel, I., Lumsden, A. L., Mulugeta, A., Mäenpää, J., Oehler, M. K., & Hyppönen, E. (2024). Large-scale analysis to identify risk factors for ovarian cancer. International Journal of Gynecological Cancer, 35(8, article no. 101844), 005424-1-005424-9.
DOI Scopus6 WoS7 Europe PMC5
2024 Duko, B., Mengistu, T. S., Stacey, D., Moran, L. J., Tessema, G., Pereira, G., . . . Hyppönen, E. (2024). Associations between maternal preconception and pregnancy adiposity and neuropsychiatric and behavioral outcomes in the offspring: a systematic review and meta-analysis. Psychiatry Research, 342(116149), 1-20.
DOI Scopus9 WoS6 Europe PMC4
2024 Yalew, M., Mulugeta, A., Lumsden, A. L., Madakkatel, I., Lee, S. H., Oehler, M. K., . . . Hyppönen, E. (2024). Circulating Phylloquinone and the Risk of Four Female-Specific Cancers: A Mendelian Randomization Study. Nutrients, 16(21), nu16213680-1-nu16213680-9.
DOI
2023 Ahmed, M., Mäkinen, V. -P., Lumsden, A., Boyle, T., Mulugeta, A., Lee, S. H., . . . Hyppönen, E. (2023). Metabolic profile predicts incident cancer: A large-scale population study in the UK Biobank.. Metabolism: clinical and experimental, 138(155342), 1-9.
DOI Scopus8 WoS8 Europe PMC6
2023 Byrne, S., Boyle, T., Ahmed, M., Lee, S. H., Benyamin, B., & Hyppönen, E. (2023). Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types.. International journal of epidemiology, 52(3), 817-826.
DOI Scopus68 WoS63 Europe PMC60
2023 Solé Navais, P., Flatley, C., Steinthorsdottir, V., Vaudel, M., Jacobsson, B., & Hypponen, E. (2023). Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics, 55(4), 559-567.
DOI Scopus52 WoS51 Europe PMC66
2023 Solé-Navais, P., Flatley, C., Steinthorsdottir, V., Vaudel, M., Juodakis, J., Chen, J., . . . Jacobsson, B. (2023). Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature Genetics, (2023), 55, 4, (559-567), 10.1038/s41588-023-01343-9). Nature Genetics, 55(7), 1250.
DOI
2023 Madakkatel, I., Lumsden, A. L., Mulugeta, A., Olver, I., & Hyppönen, E. (2023). Hypothesis-free discovery of novel cancer predictors using machine learning. European Journal of Clinical Investigation, 53(10), 1-13.
DOI Scopus4 WoS4 Europe PMC4
2023 Mulugeta, A., Suppiah, V., & Hyppönen, E. (2023). Schizophrenia and co-morbidity risk: Evidence from a data driven phenomewide association study. Journal of Psychiatric Research, 162, 1-10.
DOI Scopus10 WoS8 Europe PMC8
2023 Mulugeta, A., Suppiah, V., & Hypponen, E. (2023). Schizophrenia and co-morbidity risk: Evidence from a data driven phenomewide association study (vol 162, pg 1, 2023]. JOURNAL OF PSYCHIATRIC RESEARCH, 165, 344.
DOI
2023 Pham, K., Mulugeta, A., Lumsden, A., & Hyppӧnen, E. (2023). Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: A Mendelian randomization phenome-wide association study in the UK Biobank. British Journal of Clinical Pharmacology, 89(10), 2992-3004.
DOI Scopus5 WoS5 Europe PMC4
2023 Mathieson, I., Day, F. R., Barban, N., Tropf, F. C., Hyppӧnen, E., & Perry, J. R. B. (2023). Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus. Nature Human Behaviour, 7(5), 790-801.
DOI Scopus25 WoS25 Europe PMC35
2023 Zhou, A., & Hyppönen, E. (2023). Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study. International journal of epidemiology, 52(1), 260-271.
DOI Scopus85 WoS84 Europe PMC70
2023 Lumme, J., Morin Papunen, L., Pesonen, P., Sebert, S., Hyppönen, E., Järvelin, M. R., . . . Niinimäki, M. (2023). Vitamin D status in women with a history of infertility and decreased fecundability: a population-based study. Nutrients, 15(11), 1-13.
DOI Scopus8 WoS8 Europe PMC7
2023 Sutherland, J. P., Zhou, A., & Hyppönen, E. (2023). Muscle traits, sarcopenia, and sarcopenic obesity: a vitamin D Mendelian randomization study. Nutrients, 15(12), 1-13.
DOI Scopus16 WoS12 Europe PMC12
2023 Lumsden, A. L., Mulugeta, A., Makinen, V. P., & Hypponen, E. (2023). Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition. Diabetes Obesity & Metabolism, 25(1), 121-131.
DOI Scopus8 WoS8 Europe PMC6
2022 Mulugeta, A., Navale, S. S., Lumsden, A. L., Llewellyn, D. J., & Hyppönen, E. (2022). Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank. Nutrients, 14(19, article no. 3907), 1-13.
DOI Scopus12 WoS13 Europe PMC10
2022 Sutherland, J. P., Zhou, A., & Hyppönen, E. (2022). Vitamin D deficiency increases mortality risk in the UK biobank: a nonlinear Mendelian Randomization Study. Annals of Internal Medicine, 175(11), 1552-1559.
DOI Scopus100 WoS94 Europe PMC84
2022 Hyppönen, E., Vimaleswaran, K. S., & Zhou, A. (2022). Genetic determinants of 25-hydroxyvitamin D concentrations and their relevance to public health. Nutrients, 14(20, article no. 4408), 1-14.
DOI Scopus32 WoS29 Europe PMC31
2022 Lumsden, A. L., Mulugeta, A., & Hyppönen, E. (2022). Milk consumption and risk of twelve cancers: a large-scale observational and Mendelian randomisation study. Clinical Nutrition, 42(1), 1-8.
DOI Scopus22 WoS20 Europe PMC19
2022 Mulugeta, A., Eshetie, T. C., Kassie, G. M., Erku, D., Mekonnen, A., Lumsden, A., & Hypponen, E. (2022). Association between metabolically different adiposity subtypes and osteoarthritis: a Mendelian Randomization Study. Arthritis Care & Research, 75(4), 885-892.
DOI Scopus10 WoS8 Europe PMC7
2022 Navale, S. S., Mulugeta, A., Zhou, A., Llewellyn, D. J., & Hyppönen, E. (2022). Vitamin D and brain health: an observational and Mendelian randomization study. The American Journal of Clinical Nutrition, 116(2), 531-540.
DOI Scopus70 WoS65 Europe PMC60
2022 Mulugeta, A., Hypponen, E., Ala Korpela, M., & Makinen, V. P. (2022). Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank. Scientific Reports, 12(1, article no. 8590), 1-11.
DOI Scopus15 WoS13 Europe PMC14
2022 Hyppönen, E., Carslake, D., Berry, D. J., Power, C., & Davey Smith, G. (2022). Estimating the influence of body mass index (BMI) on mortality using offspring BMI as an instrumental variable. International Journal of Obesity, 46(1), 77.
DOI Scopus6 WoS5 Europe PMC6
2022 Darooghegi Mofrad, M., Naghshi, S., Lotfi, K., Beyene, J., Hypponen, E., Pirouzi, A., & Sadeghi, O. (2022). Egg and dietary cholesterol intake and risk of all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Frontiers in Nutrition, 9(878979), 1-16.
DOI Scopus22 WoS18 Europe PMC13
2022 Virtanen, J. K., Nurmi, T., Aro, A., Bertone-Johnson, E. R., Hyppönen, E., Kröger, H., . . . Hantunen, S. (2022). Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial: a randomized controlled trial. American Journal of Clinical Nutrition, 115(5), 1300-1310.
DOI Scopus87 WoS88 Europe PMC69
2022 Pham, K., Mulugeta, A., Zhou, A., O'Brien, J. T., Llewellyn, D. J., & Hyppönen, E. (2022). High coffee consumption, brain volume and risk of dementia and stroke.. Nutritional Neuroscience, 25(10), 2111-2122.
DOI Scopus26 WoS29 Europe PMC25
2022 Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Hypponen, E., & Hirschhorn, J. N. (2022). A saturated map of common genetic variants associated with human height. Nature, 610(7933), 704-712.
DOI Scopus456 WoS430 Europe PMC574
2022 Dickson, C., Zhou, A., MacIntyre, E., & Hyppönen, E. (2022). Do chronic low back pain and chronic widespread pain differ in their association with depression symptoms in the 1958 British Cohort?. Pain Med, 24(6), 23 pages.
DOI Scopus7 WoS8 Europe PMC6
2022 Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hyppönen, E., & den Hoed, M. (2022). Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature Genetics, 54(9), 1332-1344.
DOI Scopus145 WoS148 Europe PMC169
2022 Shin, J., Zhou, X., Tan, J. T. M., Hyppönen, E., Benyamin, B., & Lee, S. H. (2022). Lifestyle Modifies the Diabetes-Related Metabolic Risk, Conditional on Individual Genetic Differences. Frontiers in Genetics, 13(759309), 759309-1-759309-10.
DOI Scopus7 WoS7 Europe PMC8
2022 Ahmed, M., Mäkinen, V. -P., Mulugeta, A., Shin, J., Boyle, T., Hyppönen, E., & Lee, S. H. (2022). Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology. Communications biology, 5(1, article no. 614), 1-14.
DOI Scopus13 WoS13 Europe PMC12
2022 Neumann, A., Nolte, I. M., Pappa, I., Ahluwalia, T. S., Pettersson, E., Rodriguez, A., . . . Tiemeier, H. (2022). A genome-wide association study of total child psychiatric problems scores. Plos One, 17(8 August), 23 pages.
DOI Scopus18 WoS16 Europe PMC25
2022 Jami, E. S., Hammerschlag, A. R., Ip, H. F., Allegrini, A. G., Benyamin, B., Border, R., . . . Middeldorp, C. M. (2022). Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. Journal of the American Academy of Child and Adolescent Psychiatry, 61(7), 934-945.
DOI Scopus41 WoS36 Europe PMC48
2021 Byrne, S., Boyle, T., Benyamin, B., Lee, S. H., Ahmed, M., & Hypponen, E. (2021). Do associations between a healthy lifestyle and incidence of cancer differ by genetic risk?. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 50(Supplement_1), 40.
DOI
2021 Sutherland, J. P., Zhou, A., Leach, M. J., & Hypponen, E. (2021). Differences and determinants of vitamin D deficiency among UK biobank participants: a cross-ethnic and socioeconomic study. Clinical Nutrition, 40(5), 3436-3447.
DOI Scopus44 WoS42 Europe PMC40
2021 Ahmed, M., Mulugeta, A., Lee, S. H., Mäkinen, V. P., Boyle, T., & Hyppönen, E. (2021). Adiposity and cancer: a Mendelian randomization analysis in the UK biobank. International Journal of Obesity, 45(12), 2657-2665.
DOI Scopus32 WoS27 Europe PMC26
2021 Madakkatel, I., Zhou, A., McDonnell, M. D., & Hyppönen, E. (2021). Combining machine learning and conventional statistical approaches for risk factor discovery in a large cohort study. Scientific Reports, 11(1, article no. 22997), 11 pages.
DOI Scopus46 WoS43 Europe PMC38
2021 Zhou, A., Selvanayagam, J. B., & Hyppönen, E. (2021). Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk. European heart journal, 43(18), 1731-1739.
DOI Scopus156 WoS150 Europe PMC125
2021 Vimaleswaran, K. S., Zhou, A., Cavadino, A., & Hyppönen, E. (2021). Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals. International Journal of Obesity, 45(8), 1751-1762.
DOI Scopus22 WoS22 Europe PMC19
2021 Lumme, J. E., Savukoski, S. M., Suvanto, E. T. J., Pesonen, P. R. O., Auvinen, J. P., Sebert, S., . . . Niinimäki, M. (2021). Early-onset climacterium is not associated with impaired vitamin D status: a population-based study. Menopause (New York, N.Y.), 28(8), 899-908.
DOI Scopus1 WoS1 Europe PMC1
2021 Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Pers, T. H., . . . Hyppӧnen, E. (2021). Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nature Human Behaviour, 5(12), 1717-1730.
DOI Scopus106 Europe PMC102
2021 Zhou, A., & Hyppönen, E. (2021). Habitual coffee intake and plasma lipid profile: evidence from UK Biobank. Clinical Nutrition, 40(6), 4404-4413.
DOI Scopus26 WoS23 Europe PMC20
2021 Mulugeta, A., Lumsden, A., & Hyppönen, E. (2021). Relationship between serum 25(Oh)d and depression: causal evidence from a bi-directional mendelian randomization study. Nutrients, 13(1), 1-13.
DOI Scopus22 WoS22 Europe PMC20
2021 Mulugeta, A., Lumsden, A., & Hyppönen, E. (2021). Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: a Mendelian randomization study. Neurobiology of Aging, 102, 161-169.
DOI Scopus21 WoS21 Europe PMC23
2021 Hyppönen, E., & Zhou, A. (2021). Cardiovascular symptoms affect the patterns of habitual coffee consumption. American Journal of Clinical Nutrition, 114(1), 214-219.
DOI Scopus14 WoS14 Europe PMC7
2021 Bejar, C. A., Goyal, S., Afzal, S., Mangino, M., Zhou, A., Hyppönen, E., & Sanghera, D. K. (2021). A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans. Nutrition Journal, 20(1), 1-11.
DOI Scopus15 WoS15 Europe PMC14
2021 Najjar, L., Sutherland, J., Zhou, A., & Hyppönen, E. (2021). Vitamin D and type 1 diabetes risk: a systematic review and meta-analysis of genetic evidence. Nutrients, 13(12, article no. 4260), 1-15.
DOI Scopus14 WoS14 Europe PMC12
2020 Ranson, J. M., Lourida, I., Hannon, E., Littlejohns, T. J., Ballard, C., Langa, K. M., . . . Llewellyn, D. J. (2020). Genetic risk, education and incidence of dementia. Alzheimer S & Dementia, 16(S10), 1.
DOI
2020 Ranson, J. M., Lourida, I., Hannon, E., Littlejohns, T. J., Ballard, C., Langa, K. M., . . . Llewellyn, D. J. (2020). Stroke, genetic risk and incidence of dementia. Alzheimer S & Dementia, 16(S10), 1.
DOI
2020 King, C., Mulugeta, A., Nabi, F., Walton, R., Zhou, A., & Hyppönen, E. (2020). Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions. EClinicalMedicine, 26(100488), 1-7.
DOI Scopus20 WoS20 Europe PMC20
2020 Lumsden, A. L., Mulugeta, A., Zhou, A., & Hyppönen, E. (2020). Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. EBioMedicine, 59(102954), 1-11.
DOI Scopus203 WoS199 Europe PMC207
2020 Stasinopoulos, L. C., Zhou, A., & Hypponen, E. (2020). Association of supplemental calcium and dairy milk intake with all-cause and cause-specific mortality in the UK Biobank: a prospective cohort study. British Journal of Nutrition, 123(5), 574-582.
DOI Scopus9 WoS8 Europe PMC9
2020 Nicolopoulos, K., Mulugeta, A., Zhou, A., & Hypponen, E. (2020). Association between habitual coffee consumption and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank. Clinical Nutrition, 39(11), 3467-3476.
DOI Scopus36 WoS35 Europe PMC33
2020 Hypponen, E. (2020). Commentary: Intergenerational BMI association: Is there a role for fetal programming?. International Journal of Epidemiology, 49(1), 244-245.
DOI Scopus2 WoS2 Europe PMC1
2020 Mulugeta, A., Zhou, A., King, C., & Hyppönen, E. (2020). Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank. Molecular psychiatry, 25(7), 1469-1476.
DOI Scopus71 WoS73 Europe PMC77
2020 Palaniswamy, S., Gill, D., De Silva, N. M., Lowry, E., Jokelainen, J., Karhu, T., . . . Järvelin, M. R. (2020). Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. The American journal of clinical nutrition, 111(5), 1036-1047.
DOI Scopus42 WoS38 Europe PMC31
2020 Zheng, Y., Huang, T., Wang, T., Mei, Z., Zhou, A., Hypponen, E., & Qi, L. (2020). Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. European Journal of Epidemiology, 35(7), 685-697.
DOI Scopus11 WoS11 Europe PMC9
2020 Zhou, X., van der Werf, J., Carson-Chahhoud, K., Ni, G., McGrath, J., Hyppönen, E., & Lee, S. H. (2020). Whole-genome approach discovers novel genetic and nongenetic variance components modulated by lifestyle for cardiovascular health. Journal of the American Heart Association, 9(8), 1-42.
DOI Scopus11 WoS11 Europe PMC13
2020 Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Hyppönen, E., & Felix, J. F. (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genetics, 16(10, article no. e1008718), 1-26.
DOI Scopus152 WoS144 Europe PMC154
2020 Dickson, C., & Hyppönen, E. (2020). Precision health: a primer for physiotherapists. Physiotherapy, 107, 66-70.
DOI Scopus4 WoS4 Europe PMC3
2020 Li, L. S. K., Williams, M. T., Johnston, K. N., Frith, P., Hypponen, E., & Paquet, C. (2020). Parental and life-course influences on symptomatic airflow obstruction. ERJ Open Research, 6(1), 1-11.
DOI Scopus8 WoS7 Europe PMC7
2019 Tyrrell, J., Mulugeta, A., Wood, A. R., Zhou, A., Beaumont, R. N., Tuke, M. A., . . . Hyppӧnen, E. (2019). Using genetics to understand the causal influence of higher BMI on depression. International journal of epidemiology, 48(3), 834-848.
DOI Scopus168 WoS153 Europe PMC148
2019 Mulugeta, A., Zhou, A., Vimaleswaran, K. S., Dickson, C., & Hyppönen, E. (2019). Depression increases the genetic susceptibility to high body mass index: Evidence from UK Biobank. Depression and Anxiety, 36(12), 1154-1162.
DOI Scopus37 WoS35 Europe PMC33
2019 Warrington, N. M., Beaumont, R. N., Horikoshi, M., Day, F. R., Freathy, R. M., & Hypponen, E. (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature genetics, 51(5), 804-814.
DOI Scopus408 WoS397 Europe PMC430
2019 Middeldorp, C. M., Felix, J. F., Mahajan, A., Ahluwalia, T. S., Auvinen, J., Bartels, M., . . . Uitterlinden, A. G. (2019). The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. European Journal of Epidemiology, 34(3), 279-300.
DOI Scopus27 WoS25 Europe PMC29
2019 Linnér, R. K., Biroli, P., Kong, E., Meddens, S. F. W., Beauchamp, J. P., & Hyppönen, E. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature genetics, 51(2), 245-257.
DOI Scopus486 WoS474 Europe PMC519
2019 Zhou, A., Morris, H. A., & Hyppönen, E. (2019). Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank. Osteoporosis International, 30(11), 2343-2348.
DOI Scopus21 WoS21 Europe PMC18
2019 Huang, T., Wang, T., Zheng, Y., Ellervik, C., Zhou, A., Hyppönen, E., & Qi, L. (2019). Association of birth weight with type 2 diabetes and glycemic traits: a mendelian randomization study. JAMA network open, 2(9, article no. e1910915), 1-18.
DOI Scopus47 WoS45 Europe PMC44
2019 Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Hyppönen, E., & Jaddoe, V. W. V. (2019). A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Human Molecular Genetics, 28(19), 3327-3338.
DOI Scopus92 WoS86 Europe PMC88
2019 Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., . . . Dehghan, A. (2019). Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovascular Disorders, 19(1), 10 pages.
DOI Scopus28 WoS23 Europe PMC32
2019 Alves, A. C., De Silva, N. M. G., Karhunen, V., Sovio, U., Das, S., Rob Taal, H., . . . Järvelin, M. R. (2019). GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances, 5(9), 1-17.
DOI Scopus101 WoS93 Europe PMC105
2019 Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Hyppönen, E., & Feenstra, B. (2019). Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nature communications, 10(3927), 1-13.
DOI Scopus66 WoS33 Europe PMC69
2019 Melaku, Y. A., Renzaho, A., Gill, T. K., Taylor, A. W., Dal Grande, E., de Courten, B., . . . Kinfu, Y. (2019). Burden and trend of diet-related non-communicable diseases in Australia and comparison with 34 OECD countries, 1990–2015: findings from the Global Burden of Disease Study 2015. European Journal of Nutrition, 58(3), 1299-1313.
DOI Scopus64 WoS57 Europe PMC45
2019 Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Zhou, A., Hyppönen, E., & Linneberg, A. (2019). Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction, 114(2), 216-225.
DOI Scopus24 WoS21 Europe PMC18
2019 Folley, S., Zhou, A., Llewellyn, D. J., & Hyppenen, E. (2019). Physical activity, APOE genotype, and cognitive decline: exploring gene-environment interactions in the UK Biobank. Journal of Alzheimers disease, 71(3), 741-750.
DOI Scopus18 WoS18 Europe PMC17
2019 Zhou, A., & Hypponen, E. (2019). Reply to PA Atroszko. The American journal of clinical nutrition, 110(5), 1259-1260.
DOI
2019 Zhou, A., & Hyppönen, E. (2019). Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases. The American journal of clinical nutrition, 109(3), 509-516.
DOI Scopus84 WoS78 Europe PMC64
2019 Ni, G., van der Werf, J., Zhou, X., Hyppönen, E., Wray, N. R., & Lee, S. H. (2019). Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model. Nature communications, 10(1, article no. 2239), 1-15.
DOI Scopus43 WoS40 Europe PMC49
2019 Lourida, I., Hannon, E., Littlejohns, T. J., Langa, K. M., Hyppӧnen, E., Kuźma, E., & Llewellyn, D. J. (2019). Association of lifestyle and genetic risk with incidence of dementia. JAMA, 322(5), 430-437.
DOI Scopus635 WoS620 Europe PMC579
2019 Hypponen, E., Mulugeta, A., Zhou, A., & Santhanakrishnan, V. K. (2019). A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank. The Lancet digital health, 1(3), e116-e126.
DOI Scopus56 WoS55 Europe PMC67
2019 Gill, D., Benyamin, B., Moore, L. S. P., Monori, G., Zhou, A., Koskeridis, F., . . . Tzoulaki, I. (2019). Associations of genetically determined iron status across the phenome: a mendelian randomization study. PLOS medicine, 16(6, article no. e1002833), 1-16.
DOI Scopus51 WoS47 Europe PMC52
2019 Kuzma, E., Lourida, I., Hannon, E., Littlejohns, T. J., Langa, K. M., Hypponen, E., & Llewellyn, D. J. (2019). O3‐05‐02: Genetic risk, lifestyle and dementia. Alzheimer S & Dementia, 15(7S), 890.
DOI
2018 Jolliffe, D. A., James, W. Y., Hooper, R. L., Barnes, N. C., Greiller, C. L., Islam, K., . . . Martineau, A. R. (2018). Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK. Journal of steroid biochemistry and molecular biology, 175, 138-145.
DOI Scopus36 WoS33 Europe PMC31
2018 Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D. A., . . . Llewellyn, D. J. (2018). Which risk factors causally influence Dementia? A systematic review of Mendelian randomization studies. Journal of Alzheimer's disease, 64(1), 181-193.
DOI Scopus43 WoS43 Europe PMC37
2018 He, Y., Timofeeva, M., Farrington, S. M., Vaughan Shaw, P., Hypponen, E., & Dunlop, M. G. (2018). Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study. BMC medicine, 16(1), 1-11.
DOI Scopus59 WoS56 Europe PMC53
2018 Folley, S., Zhou, A., & Hypponen, E. (2018). Information bias in measures of self-reported physical activity. International journal of obesity, 42(12), 2062-2063.
DOI Scopus18 WoS18 Europe PMC18
2018 Mulugeta, A., Zhou, A., Power, C., & Hyppönen, E. (2018). Obesity and depressive symptoms in mid-life: a population-based cohort study. BMC Psychiatry, 18(297), 1-10.
DOI Scopus54 WoS53 Europe PMC44
2018 Hyppönen, E., & Boucher, B. J. (2018). Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutrition reviews, 76(9), 678-692.
DOI Scopus70 WoS64 Europe PMC56
2018 Beaumont, R., Warrington, N., Cavadino, A., Tyrrell, J., Nodzenski, M., Horikoshi, M., . . . Murabito, J. (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics, 27(4), 742-756.
DOI Scopus144 WoS139 Europe PMC144
2018 Jolliffe, D. A., Kilpin, K., MacLaughlin, B. D., Greiller, C. L., Hooper, R. L., Barnes, N. C., . . . Martineau, A. R. (2018). Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK. Journal of steroid biochemistry and molecular biology, 175, 88-96.
DOI Scopus14 WoS16 Europe PMC13
2018 Zhou, A., & Hyppönen, E. (2018). The Alleged Health-Protective Effects of Coffee. JAMA Internal Medicine, 178(12), 1725.
DOI WoS1
2018 Jiang, X., O'Reilly, P. F., Aschard, H., Hsu, Y. H., Zhou, A., Hypponen, E., & Kiel, D. P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature communications, 9(1, article no. 260), 1-12.
DOI Scopus333 WoS326 Europe PMC303
2018 Zhou, A., Taylor, A. E., Karhunen, V., Zhan, Y., & Hypponen, E. (2018). Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific reports, 8(7526), 1-9.
DOI Scopus45 WoS44 Europe PMC35
2018 Lee, J. J., Wedow, R., Okbay, A., Kong, E., Cesarini, D., & Hyppönen, E. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature genetics, 50(8), 1112-1121.
DOI Scopus1701 Europe PMC1705
2017 Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A. -L., Foecker, M., Antel, J., . . . Hebebrand, J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22(2), 192-201.
DOI Scopus54 WoS39 Europe PMC34
2017 Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., . . . Völker, U. (2017). PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet Diabetes and Endocrinology, 5(2), 97-105.
DOI Scopus319 WoS296 Europe PMC285
2017 Dale, C., Fatemifar, G., Palmer, T., White, J., Prieto-Merino, D., Zabaneh, D., . . . Casas, J. (2017). Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and type 2 diabetes mellitus: a Mendelian randomization analysis. Circulation, 135(24), 2373-2388.
DOI Scopus292 WoS282 Europe PMC279
2017 Skaaby, T., Taylor, A. E., Jacobsen, R. K., Paternoster, L., Zhou, A., Hyppönen, E., & Linneberg, A. (2017). Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium. Scientific reports, 7(2224), 1-9.
DOI Scopus42 WoS39 Europe PMC32
2017 Berry, D. J., Dutton, J., Fraser, W. D., Järvelin, M. R., & Hyppönen, E. (2017). Harmonization study between LC-MS/MS and diasorin RIA for measurement of 25-hydroxyvitamin D concentrations in a large population survey. Journal of clinical laboratory analysis, 31(3, article no. e22049), 1-10.
DOI Scopus14 WoS14 Europe PMC13
2017 Palaniswamy, S., Hyppönen, E., Williams, D. M., Jokelainen, J., Lowry, E., Keinänen Kiukaanniemi, S., . . . Sebert, S. (2017). Potential determinants of Vitamin D in Finnish adults: A cross-sectional study from the Northern Finland birth cohort 1966. BMJ Open, 7(e013161), 1-11.
DOI Scopus29 WoS28 Europe PMC22
2017 Tripkovic, L., Wilson, L. R., Hart, K., Johnsen, S., de Lusignan, S., Smith, C. P., . . . Lanham New, S. A. (2017). Daily supplementation with 15 µg vitamin D₂ compared with vitamin D₃ to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. American journal of clinical nutrition, 106(2), 481-490.
DOI Scopus94 WoS87 Europe PMC71
2017 Berti, C., Agostoni, C., Davanzo, R., Hyppönen, E., Isolauri, E., Meltzer, H. M., . . . Cetin, I. (2017). Early-life nutritional exposures and lifelong health: Immediate and long-lasting impacts of probiotics, vitamin D, and breastfeeding. Nutrition reviews, 75(2), 83-97.
DOI Scopus53 WoS40 Europe PMC31
2017 Maddock, J., Zhou, A., Cavadino, A., Kuźma, E., & Hyppönen, E. (2017). Vitamin D and cognitive function: A Mendelian randomisation study. Scientific Reports, 7(1, article no. 13230), 1-8.
DOI Scopus55 WoS49 Europe PMC38
2016 Williams, D. M., Palaniswamy, S., Sebert, S., Buxton, J. L., Blakemore, A. I. F., Hyppönen, E., & Jarvelin, M. R. (2016). 25-Hydroxyvitamin D concentration and leukocyte telomere length in young adults: findings from the Northern Finland Birth Cohort 1966. American Journal of Epidemiology, 183(3), 191-198.
DOI Scopus30 WoS27 Europe PMC26
2016 Jolliffe, D. A., Hanifa, Y., Witt, K. D., Venton, T. R., Rowe, M., Timms, P. M., . . . Martineau, A. R. (2016). Environmental and genetic determinants of vitamin D status among older adults in London, UK. Journal of steroid biochemistry and molecular biology, 164, 30-35.
DOI Scopus33 WoS31 Europe PMC23
2016 Zanoni, P., Khetarpal, S. A., Larach, D. B., Hancock Cerutti, W. F., Rader, D. J., & Hypponen, E. (2016). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science, 351(6278), 1166-1178.
DOI
2016 Evazpoor, A., Edalati, A., Hypponen, E., Fararouei, M., & Parisai, Z. (2016). Deaths of children aged under 5 years and related factors in the Islamic Republic of Iran: a population-based case-control study. Eastern Mediterranean health journal, 22(6), 368-374.
DOI Scopus6 WoS5 Europe PMC3
2016 Okbay, A., Baselmans, B. M. L., De Neve, J. -E., Turley, P., Nivard, M. G., Fontana, M. A., . . . Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016). NATURE GENETICS, 48(12), 1591.
DOI WoS8
2016 Okbay, A., Baselmans, B. M. L., De Neve, J. -E., Turley, P., Nivard, M. G., Fontana, M. A., . . . Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016). NATURE GENETICS, 48(8), 970.
DOI WoS5
2016 Schmidt, A. F., Hingorani, A. D., Jefferis, B. J., White, J., Dudbridge, F., Groenwold, R. H. H., . . . Whincup, P. (2016). Comparison of variance estimators for metaanalysis of instrumental variable estimates. International Journal of Epidemiology, 45(6), 1975-1986.
DOI Scopus5 Europe PMC4
2016 Munns, C., Shaw, N., Kiely, M., Specker, B., Thacher, T., Ozono, K., . . . Hogler, W. (2016). Global consensus recommendations on prevention and management of nutrition rickets. Pediatriya, 56(1), 60-63.
Scopus2
2016 Jacobsen, R., Moldovan, M., Vaag, A. A., Hypponen, E., & Heitmann, B. L. (2016). Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study. Journal of Developmental Origins of Health and Disease, 7(1), 114-119.
DOI Scopus13 WoS11 Europe PMC10
2016 Okbay, A., Beauchamp, J. P., Fontana, M. A., Lee, J. J. J., Hypponen, E., & Benjamin, D. J. (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533(7604), 539-542.
DOI Scopus922 WoS877 Europe PMC890
2016 White, J., Sofat, R., Hemani, G., Shah, T., Engmann, J., Dale, C., . . . Hingorani, A. (2016). Plasma urate concentration and risk of coronary heart disease: A Mendelian randomisation analysis. The Lancet Diabetes and Endocrinology, 4(4), 327-336.
DOI Scopus101 WoS99 Europe PMC87
2016 Okbay, A., Baselmans, B. M. L., De Neve, J. E., Turley, P., Hyppönen, E., & Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(6), 624-633.
DOI Scopus727 WoS681 Europe PMC700
2016 Pappa, I., St, P. B., Benke, K., Cavadino, A., Hypponen, E., & Tiemeier, H. (2016). A genome-wide approach to children's aggressive behavior: The EAGLE consortium. American journal of medical genetics, Part B: neuropsychiatric genetics, 171(5), 562-572.
DOI Scopus144 WoS132 Europe PMC112
2016 Tyrrell, J., Richmond, R., Palmer, T., Feenstra, B., Rangarajan, J., Metrustry, S., . . . Freathy, R. (2016). Genetic evidence for causal relationships between maternal obesity-related traits and birth weight. JAMA - Journal of the American Medical Association, 315(11), 1129-1140.
DOI Scopus208 WoS196 Europe PMC197
2016 McLachlan, S., Giambartolomei, C., White, J., Charoen, P., Wong, A., Finan, C., . . . Zabaneh, D. (2016). Replication and characterization of association between ABO SNPs and red blood cell traits by meta-analysis in Europeans. PLoS One, 11(6), e0156914-1-e0156914-18.
DOI Scopus18 WoS17 Europe PMC19
2016 Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N., Hyppönen, E., & Freathy, R. M. (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538, no. 7624, pp. 248-252(7624), 248-252.
DOI Scopus369 WoS364 Europe PMC357
2016 Barban, N., Jansen, R., De Vlaming, R., Vaez, A., Hyppönen, E., & Mills, M. C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature genetics, 48(12), 1462-1475.
DOI Scopus199 WoS197 Europe PMC190
2016 Nüesch, E., Dale, C., Palmer, T., White, J., Keating, B., van Iperen, E., . . . Casas, J. (2016). Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45(6), 1927-1937.
DOI Scopus96 WoS72 Europe PMC95
2016 Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Hypponen, E., & Benjamin, D. J. (2016). Genetic variants linked to education predict longevity. National Academy of Sciences. Proceedings, 113(47), 13366-13371.
DOI Scopus63 Europe PMC58
2016 Jacobsen, R., Moldovan, M., Vaag, A. A., Hypponen, E., & Heitmann, B. L. (2016). Erratum: Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study (Journal of Developmental Origins of Health and Disease (2016) 7 (114-119) DOI: 10.1017/S2040174415007849). Journal of Developmental Origins of Health and Disease, 7(4), 429.
DOI Scopus3 WoS4
2016 Larsen, S. C., Ängquist, L., Moldovan, M., Huikari, V., Sebert, Y., Cavadino, A., . . . Sørensen, T. I. A. (2016). Serum 25-hydroxyvitamin D status and longitudinal changes in weight and waist circumference: Influence of genetic predisposition to adiposity. PLoS ONE, 11(4), 1-18.
DOI Scopus10 WoS10 Europe PMC7
2016 Munns, C. F., Shaw, N., Kiely, M., Specker, B. L., Hyppönen, E., & Högler, W. (2016). Global consensus recommendations on prevention and management of nutritional rickets. Journal of Clinical Endocrinology and Metabolism, 101(2), 394-415.
DOI Scopus937 WoS60 Europe PMC608
2016 Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Hypponen, E., & Jaddoe, V. W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25(2), 389-403.
DOI Scopus261 WoS245 Europe PMC245
2016 Munns, C. F., Shaw, N., Kiely, M., Specker, B. L., Hyppönen, E., & Högler, W. (2016). Global consensus recommendations on prevention and management of nutritional rickets. Hormone Research in Paediatrics, 85(2), 83-106.
DOI Scopus199 WoS870 Europe PMC121
2015 Maddock, J., Cavadino, A., Power, C., & Hyppönen, E. (2015). 25-Hydroxyvitamin D, APOE ε4 genotype and cognitive function: findings from the 1958 British birth cohort. European journal of clinical nutrition, 69(4), 505-508.
DOI Scopus29 WoS29 Europe PMC25
2015 Surakka, I., Horikoshi, M., Mägi, R., Sarin, A. P., Hyppönen, E., & Ripatti, S. (2015). The impact of low-frequency and rare variants on lipid levels. Nature genetics, 47(6), 589-597.
DOI Scopus268 WoS266 Europe PMC289
2015 Vimaleswaran, K., Cavadino, A., Verweij, N., Nolte, I., Leach, I., Auvinen, J., . . . Hyppönen, E. (2015). Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study. European Journal of Endocrinology, 173(6), 863-872.
DOI Scopus9 WoS10 Europe PMC7
2015 Holmes, M., Asselbergs, F., Palmer, T., Drenos, F., Lanktree, M., Nelson, C., . . . Casas, J. (2015). Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal, 36(9), 539-550.
DOI Scopus597 WoS553 Europe PMC557
2015 Linneberg, A., Jacobsen, R., Skaaby, T., Taylor, A., Fluharty, M., Jeppesen, J., . . . Husemoen, L. (2015). Effect of smoking on blood pressure and resting heart rate: a Mendelian randomization meta-analysis in the CARTA Consortium. Circulation: Cardiovascular Genetics, 8(6), 832-841.
DOI Scopus131 WoS118 Europe PMC103
2015 Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., . . . Zhang, W. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-197.
DOI Scopus1272 WoS1245 Europe PMC1260
2015 Horikoshi, M., Mägi, R., van de Bunt, M., Surakka, I., Hypponen, E., & Morris, A. P. (2015). Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation. PLoS Genetics, 11(7, article no. e1005230), 1-24.
DOI Scopus70 WoS72 Europe PMC73
2015 Morris, R., Taylor, A., Fluharty, M., Bjørngaard, J., Åsvold, B., Gabrielsen, M., . . . Munafò, M. (2015). Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open, 5(8), e008808-1-e008808-10.
DOI Scopus50 WoS27 Europe PMC45
2015 Locke, A., Kahali, B., Berndt, S., Justice, A., Pers, T., Day, F., . . . Dimitriou, M. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206.
DOI Scopus3530 WoS3402 Europe PMC3475
2015 Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., . . . Rasheed, A. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20(5), 647-656.
DOI Scopus225 WoS211 Europe PMC192
2015 Jacobsen, R., Hypponen, E., Sørensen, T. I. A., Vaag, A. A., & Heitmann, B. L. (2015). Gestational and early infancy exposure to margarine fortified with vitamin D through a national Danish programme and the risk of type 1 diabetes: the D-tect study. PLoS one, 10(6, article no. e0128631), 1-11.
DOI Scopus24 WoS22 Europe PMC19
2015 Maddock, J., Cavadino, A., Power, C., & Hyppoenen, E. (2015). Vitamin D and cognition: findings from a Mendelian randomisation study. Faseb Journal, 29(S1), 1.
DOI
2014 Vimaleswaran, K. S., Power, C., & Hypponen, E. (2014). Interaction between vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D concentrations on metabolic and cardiovascular disease outcomes. Diabetes and metabolism, 40(5), 386-389.
DOI Scopus26 WoS27 Europe PMC16
2014 Maddock, J., Geoffroy, M. C., Power, C., & Hypponen, E. (2014). 25-Hydroxyvitamin D and cognitive performance in mid-life. British journal of nutrition, 111(5), 904-914.
DOI Scopus24 WoS25 Europe PMC18
2014 Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Mangino, M., Andrews, P., Moore, J. H., . . . Hyppönen, E. (2014). Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. BMC genetics, 15(article no. 37), 1-8.
DOI Scopus14 WoS16 Europe PMC14
2014 Smith, G. D., Hypponen, E., Moldovan, M., & Power, C. (2014). Death of siblings in childhood and subsequent mortality: prospective observational study. European journal of epidemiology, 29(11), 859-861.
DOI Scopus2 WoS2 Europe PMC2
2014 Cousminer, D., Stergiakouli, E., Berry, D., Ang, W., Groen-Blokhuis, M., Koerner, A., . . . Widen, E. (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 23(16), 4452-4464.
DOI Scopus81 WoS82 Europe PMC72
2014 Taylor, A., Morris, R., Fluharty, M., Bjorngaard, J., Åsvold, B., Gabrielsen, M., . . . Munafò, M. (2014). Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with Body Mass Index in never smokers. PLoS Genetics, 10(12), e1004799-1-e1004799-6.
DOI Scopus44 WoS46 Europe PMC44
2014 Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Gabrielsen, M. E., Hypponen, E., & Munafò, M. R. (2014). Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ open, 4(10, article no. e006141), 1-15.
DOI Scopus121 WoS110 Europe PMC99
2014 Holmes, M., Dale, C., Zuccolo, L., Silverwood, R., Guo, Y., Ye, Z., . . . Uitterlinden, A. (2014). Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349(Jul), g4164-1-g4164-16.
DOI Scopus584 WoS502 Europe PMC461
2014 Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Jorde, R., & Hyppönen, E. (2014). Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study. The Lancet Diabetes and Endocrinology, 2(9), 719-729.
DOI Scopus328 WoS307 Europe PMC267
2014 Wood, A. R., Esko, T., Yang, J., Vadantam, S., Hypponen, E., & Frayling, T. M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature genetics, 46(11), 1173-1186.
DOI Scopus1412 WoS1328 Europe PMC1386
2014 Williams, D., Fraser, A., Sayers, A., Fraser, W., Hyppönen, E., Smith, G., . . . Lawlor, D. (2014). Associations of childhood 25-hydroxyvitamin D₂ and D₃ and cardiovascular risk factors in adolescence: prospective findings from the Avon Longitudinal Study of Parents and Children. European Journal of Preventive Cardiology, 21(3), 281-290.
DOI Scopus25 WoS24 Europe PMC17
2014 Mutt, S. J., Hyppönen, E., Saarnio, J., Järvelin, M. R., & Herzig, K. H. (2014). Vitamin D and adipose tissue-more than storage. Frontiers in physiology, 5(article no. 228), 1-9.
DOI Scopus169 WoS162 Europe PMC132
2013 Kuan, V., Martineau, A. R., Griffiths, C. J., Hyppönen, E., & Walton, R. (2013). DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes. BMC evolutionary biology, 13(144), 1-10.
DOI Scopus57 WoS60 Europe PMC53
2013 Brouwer Brolsma, E. M., Bischoff Ferrari, H. A., Bouillon, R., Feskens, E. J. M., Gallagher, C. J., Hypponen, E. T., . . . de Groot, L. C. P. G. M. (2013). Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporosis International, 24(5), 1567-1577.
DOI Scopus100 WoS89 Europe PMC80
2013 Alfred, T., Ben Shlomo, Y., Cooper, R., Hardy, R., Deary, I. J., Elliott, J., . . . Day, I. N. M. (2013). Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults. Journal of nutrition, 143(5), 606-612.
DOI Scopus8 WoS7 Europe PMC6
2013 Cooper, R., Pinto Pereira, S. M., Power, C., & Hypponen, E. (2013). Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study. International journal of obesity, 37(12), 1590-1596.
DOI Scopus28 WoS26 Europe PMC21
2013 Vimaleswaran, K. S., Cavadino, A., & Hypponen, E. T. (2013). APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol. Atherosclerosis, 228(1), 188-192.
DOI Scopus7 WoS7 Europe PMC7
2013 Maddock, J., Berry, D. J., Geoffroy, M. C., Power, C., & Hyppönen, E. (2013). Vitamin D and common mental disorders in mid-life : cross-sectional and prospective findings. Clinical nutrition, 32(5), 758-764.
DOI Scopus51 WoS44 Europe PMC39
2013 Hyppönen, E., Cavadino, A., Williams, D., Fraser, A., Vereczkey, A., Fraser, W., . . . Czeizel, A. (2013). Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis. Annals of Nutrition and Metabolism, 63(4), 331-340.
DOI Scopus135 WoS130 Europe PMC114
2013 Williams, D., Fraser, A., Fraser, W., Hyppon̈en, E., Smith, G., Deanfield, J., . . . Lawlor, D. (2013). Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children. Heart, 99(24), 1849-1856.
DOI Scopus41 WoS34 Europe PMC34
2013 Shah, T., Engmann, J., Dale, C., Shah, S., White, J., Giambartolomei, C., . . . Hingorani, A. (2013). Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS One, 8(8), e71345-1-e71345-12.
DOI Scopus33 WoS33 Europe PMC37
2013 Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D., Sovio, U., Taal, H., Hennig, B., . . . Geller, F. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76-82.
DOI Scopus264 WoS252 Europe PMC244
2013 Randall, J., Winkler, T., Kutalik, Z., Berndt, S., Jackson, A., Monda, K., . . . Vedantam, S. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genetics, 9(6), e1003500-1-e1003500-19.
DOI Scopus339 WoS338 Europe PMC341
2013 Berndt, S., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M., . . . Wood, A. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45(5), 501-512.
DOI Scopus530 WoS515 Europe PMC497
2013 Vimaleswaran, K., & Palmer, L. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine, 10(2), 1001383-1-1001383-1 3.
DOI Scopus829 WoS609 Europe PMC659
2013 Cousminer, D., Berry, D., Timpson, N., Ang, W., Thiering, E., Byrne, E., . . . Palmer, L. (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22(13), 2735-2747.
DOI Scopus166 WoS156 Europe PMC152
2013 Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Hyppönen, E., & Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature genetics, 45(11), 1345-1353.
DOI Scopus728 WoS696 Europe PMC688
2013 Willer, C., Schmidt, E., Sengupta, S., Peloso, G., Hypponen, E. T., & Abecasis, G. R. (2013). Discovery and refinement of loci associated with lipid levels. Nature genetics, 45(11), 1274-1285.
DOI Scopus2445 WoS2242 Europe PMC2444
2013 Fall, T., Hagg, S., Magi, R., Ploner, A., Benyamin, B., Hypponen, E. T., & Pokoppenko, I. (2013). The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS medicine, 10(6), 1-16.
DOI Scopus176 WoS156 Europe PMC157
2013 Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Whittaker, J. C., Power, C., Jarvelin, M. R., & Hypponen, E. T. (2013). Genetic association analysis of vitamin D pathway with obesity traits. International journal of obesity, 37(10), 1399-1406.
DOI Scopus41 WoS41 Europe PMC30
2013 Maddock, J., Geoffroy, M. C., Power, C., & Hypponen, E. (2013). 25-Hydroxyvitamin D and cognitive performance in mid-life. Annals of nutrition and metabolism, 63, 849.
2013 Berry, D. J., Hypponen, E., & Cortina Borja, M. (2013). Investigating the association of vitamin D seasonality on inflammatory and hemostatic markers. Chronobiology international, 30(6), 786-795.
DOI Scopus5 WoS5 Europe PMC4
2012 Okada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., . . . Peltonen, L. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44(8), 904-909.
DOI Scopus253 WoS243 Europe PMC243
2012 Ikram, M., Fornage, M., Smith, A., Seshadri, S., Schmidt, R., Debette, S., . . . Uitterlinden, A. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-544.
DOI Scopus100 WoS112 Europe PMC114
2012 Bradfield, J., Taal, H., Timpson, N., Scherag, A., Lecoeur, C., Warrington, N., . . . St Pourcain, B. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-531.
DOI Scopus344 WoS325 Europe PMC312
2012 Taal, H., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D., Warrington, N., . . . Chawes, B. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44(5), 532-538.
DOI Scopus99 WoS102 Europe PMC107
2012 Tyrrell, J., Huikari, V., Christie, J., Cavadino, A., Bakker, R., Brion, M., . . . Freathy, R. (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Human Molecular Genetics, 21(24), 5344-5358.
DOI Scopus60 WoS60 Europe PMC58
2012 Vimaleswaran, K. S., Cavadino, A., & Hypponen, E. (2012). Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency. Allergy, 67(8), 1033-1040.
DOI Scopus20 WoS20 Europe PMC14
2012 Mutt, S. J., Karhu, T., Lehtonen, S., Lehenkari, P., Carlberg, C., Saarnio, J., . . . Herzig, K. H. (2012). Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-KB pathway. The FASEB journal, 26(11), 4400-4407.
DOI Scopus76 WoS76 Europe PMC54
2012 Angelakopoulou, A., Shah, T., Sofat, R., Shah, S., Hypponen, E., & Hingorani, A. D. (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. European heart journal, 33(3), 393-407.
DOI Scopus99 WoS94 Europe PMC76
2012 Disanto, G., Chaplin, G., Morahan, J. M., Giovannoni, G., Hyppönen, E., Ebers, G. C., & Ramagopalan, S. V. (2012). Month of birth, vitamin D and risk of immune-mediated disease: a case control study. BMC medicine, 10(article no. 69), 1-7.
DOI Scopus119 WoS111 Europe PMC102
2012 Tripkovic, L., Lambert, H., Hart, K., Smith, C. P., Bucca, G., Penson, S., . . . Lanham New, S. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. American journal of clinical nutrition, 95(6), 1357-1364.
DOI Scopus641 WoS584 Europe PMC455
2012 Berry, D. J., Vimaleswaran, K. S., Whittaker, J. C., Hingorani, A. D., & Hyppönen, E. (2012). Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D. PLoS one, 7(5), 10 pages.
DOI Scopus80 WoS76 Europe PMC65
2011 Cooper, J. D., Smyth, D. J., Walker, N. M., Stevens, H., Burren, O. S., Wallace, C., . . . Todd, J. A. (2011). Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes, 60(5), 1624-1631.
DOI Scopus240 WoS219 Europe PMC191
2011 Hypponen, E. T. (2011). Preventing vitamin D deficiency in pregnancy - importance for the mother and child. Annals of nutrition and metabolism, 59(1), 28-31.
DOI Scopus31 WoS27 Europe PMC21
2011 Ward, M., Berry, D. J., Power, C., & Hyppönen, E. (2011). Working patterns and vitamin D status in mid-life: a cross-sectional study of the 1958 British birth cohort. Occupational and environmental medicine, 68(12), 902-907.
DOI Scopus33 WoS32 Europe PMC27
2011 Hypponen, E. T., & Boucher, B. (2011). Need to be implemented in UK. BMJ, 342(7791), 244.
DOI
2011 Berry, D. J., Hesketh, K., Power, C., & Hypponen, E. T. (2011). Vitamin D status has a linear association with seasonal infections and lung function in British adults. British journal of nutrition, 106(9), 1433-1440.
DOI Scopus224 WoS155 Europe PMC172
2011 Hypponen, E., Fararouei, M., Sovio, U., Hartikainen, A., Pouta, A., Robertson, C., . . . Jarvelin, M. (2011). High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort. Journal of nutrition, 141(5), 843-848.
DOI Scopus18 WoS16 Europe PMC12
2011 Berry, D., & Hypponen, E. (2011). Determinants of vitamin D status: focus on genetic variations. Current opinion in nephrology and hypertension, 20(4), 331-336.
DOI Scopus83 WoS77 Europe PMC65
2011 Zabaneh, D., Gaunt, T., Kumari, M., Drenos, F., Shah, S., Berry, D., . . . Humphries, S. (2011). Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip. Annals of Human Genetics, 75(4), 456-467.
DOI Scopus28 WoS25 Europe PMC23
2011 Kilpeläinen, T., Qi, L., Brage, S., Sharp, S., Sonestedt, E., Demerath, E., . . . Marmot, M. (2011). Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children. PLoS Medicine, 8(11), 14 pages.
DOI Scopus469 WoS427 Europe PMC382
2011 Chambers, J., & Palmer, L. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1138.
DOI Scopus466 WoS450 Europe PMC448
2011 Kilpelainen, T., den Hoed, M., Ong, K., Grontved, A., Brage, S., Early Growth Genetics Consortium., . . . Loos, R. (2011). Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93(4), 851-860.
DOI Scopus55 WoS51 Europe PMC43
2011 Lanham New, S. A., Buttriss, J. L., Miles, L. M., Ashwell, M., Hyppöpnen, E., & Williams, C. M. (2011). Proceedings of the rank forum on vitamin D. British journal of nutrition, 105(1), 144-156.
DOI Scopus85 Europe PMC50
2011 Disanto, G., Handel, A. E., Morahan, J. M., Deluca, G. C., Kimball, S. M., Hypponen, E., . . . Ramagopalan, S. V. (2011). Vitamin D and multiple sclerosis hospital admissions in Scotland. QJM, 104(11), 1001-1003.
DOI Scopus7 WoS5 Europe PMC4
2010 Freathy, R., Mook-Kanamori, D., Sovio, U., Prokopenko, I., Timpson, N., Berry, D., . . . Bennett, A. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42(5), 430-435.
DOI Scopus206 WoS195 Europe PMC182
2010 Chambers, J. C., Zhang, W., Lord, G. M., Van der Harst, P., Hypponen, E., & Kooner, J. S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature genetics, 42(5), 373-375.
DOI Scopus243 WoS228 Europe PMC211
2010 Hypponen, E., Berry, D., Cortina Borja, M., & Power, C. (2010). 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British birth cohort. PLoS one, 5(5), 1-8.
DOI Scopus93 WoS85 Europe PMC70
2010 Wang, T., Zhang, F., Richards, J. B., Kestenbaum, B., Hypponen, E., & Spector, T. D. (2010). Common genetic determinants of vitamin D insufficiency : a genome-wide association study. The lancet, 376(9736), 180-188.
DOI Scopus1413 WoS1295 Europe PMC1153
2010 Hypponen, E., & Boucher, B. J. (2010). Avoidance of vitamin D deficiency in pregnancy in the United Kingdom: the case for a unified approach in National policy. British Journal of Nutrition, 104(3), 309-314.
DOI Scopus53 WoS48 Europe PMC39
2010 Hyppönen, E. (2010). Vitamin D and increasing incidence of type 1 diabetes - evidence for an association?. Diabetes, obesity and metabolism, 12(9), 737-743.
DOI Scopus70 WoS64 Europe PMC46
2010 Cooper, R., Hypponen, E., Berry, D., & Power, C. (2010). Associations between parental and offspring adiposity up to midlife: the contribution of adult lifestyle factors in the 1958 british birth cohort study. American Journal of Clinical Nutrition, 92(4), 946-953.
DOI Scopus68 WoS64 Europe PMC64
2010 Harville, E. W., Boynton Jarrett, R., Power, C., & Hypponen, E. (2010). Childhood hardship, maternal smoking, and birth outcomes: a prospective cohort study. Archives of Pediatrics and Adolescent Medicine, 164(6), 533-539.
DOI Scopus53 WoS52 Europe PMC46
2010 Fararouei, M., Robertson, C., Whittaker, J., Sovio, U., Ruokonen, A., Hartikainen, A. L., . . . Hypponen, E. (2010). Maternal Hb during pregnancy and offspring's educational achievement: a prospective cohort study over 30 years. British Journal of Nutrition, 104(9), 1363-1368.
DOI Scopus19 WoS19 Europe PMC18
2009 Atherton, K., Berry, D. J., Parsons, T., Macfarlane, G. J., Power, C., & Hyppönen, E. (2009). Vitamin D and chronic widespread pain in a white middle-aged British population: Evidence from a cross-sectional population survey. Annals of the rheumatic diseases, 68(6), 817-822.
DOI Scopus119 WoS105 Europe PMC79
2009 Hyppönen, E., Berry, D. J., Wjst, M., & Power, C. (2009). Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. Allergy, 64(4), 613-620.
DOI Scopus218 WoS200 Europe PMC164
2009 Freathy, R. M., Bennett, A. J., Ring, S. M., Shields, B., Hypponen, E., & Hattersley, A. T. (2009). Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes, 58(6), 1428-1433.
DOI Scopus121 WoS106 Europe PMC95
2008 Hypponen, E., Boucher, B. J., Berry, D. J., & Power, C. (2008). 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British birth cohort. Diabetes, 57(2), 298-305.
DOI Scopus336 WoS312 Europe PMC267
2008 Hypponen, E. T. (2008). Birth weight and risk of type 2 diabetes a systematic review. JAMA : journal of the American Medical Association, 300(24), 2886-2897.
DOI Scopus814 WoS735 Europe PMC660
2008 Thomas, C., Hyppönen, E., & Power, C. (2008). Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity. Pediatrics, 121(5), 1240-1249.
DOI Scopus290 WoS267 Europe PMC233
2007 Hyppönen, E., Turner, S., Cumberland, P., Power, C., & Gibb, I. (2007). Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. Journal of Clinical Endocrinology and Metabolism, 92(12), 4615-4622.
DOI Scopus67 WoS59 Europe PMC50
2007 Hyppönen, E., Hartikainen, A. L., Sovio, U., Järvelin, M. R., & Pouta, A. (2007). Does vitamin D supplementation in infancy reduce the risk of pre-eclampsia?. European Journal of Clinical Nutrition, 61(9), 1136-1139.
DOI Scopus54 WoS44 Europe PMC39
2007 Freathy, R. M., Weedon, M. N., Bennett, A., Hyppönen, E., Relton, C. L., Knight, B., . . . Frayling, T. M. (2007). Type 2 diabetes TCF7L2 risk genotypes alter birth weight: A study of 24,053 individuals. American Journal of Human Genetics, 80(6), 1150-1161.
DOI Scopus105 WoS96 Europe PMC81
2007 Thomas, C., Hypp̈onen, E., & Power, C. (2007). Prenatal exposures and glucose metabolism in adulthood: Are effects mediated through birth weight and adiposity?. Diabetes Care, 30(4), 918-924.
DOI Scopus49 WoS47 Europe PMC44
2007 Thomas, C., Hyppönen, E., & Power, C. (2007). Diabetes risk in British adults in mid life: A national prevalence study of glycated haemoglobin. Diabetic Medicine, 24(3), 317-321.
DOI Scopus11 WoS12 Europe PMC10
2007 Hyppönen, E., & Power, C. (2007). Hypovitaminosis D in British adults at age 45 y: Nationwide cohort study of dietary and lifestyle predictors. American Journal of Clinical Nutrition, 85(3), 860-868.
DOI Scopus672 WoS618 Europe PMC524
2006 Hyppönen, E., & Power, C. (2006). Vitamin D status and glucose homeostasis in the 1958 British birth cohort the role of obesity. Diabetes Care, 29(10), 2244-2246.
DOI Scopus244 WoS223 Europe PMC170
2000 Virtanen, S. M., Laara, E., Hypponen, E., Reijonen, H., Rasanen, L., Aro, A., . . . Akerblom, H. K. (2000). Erratum: Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes - A nested case-control study of siblings of children with diabetes (Diabetes (2000) 49(912-917)). Diabetes, 49(9), 1617.
1998 Virtanen, S. M., Hyppönen, E., Läärä, E., Vähäsalo, P., Kulmala, P., Savola, K., . . . Tuomilehto-Wolf, E. (1998). Cow's milk consumption, disease-associated autoantibodies and Type 1 diabetes mellitus: A follow-up study in siblings of diabetic children. Diabetic Medicine, 15(9), 730-738.
DOI Scopus96 WoS69 Europe PMC47

Year Citation
2021 Sutherland, J., Zhou, A., Leach, M., & Hypponen, E. (2021). Ethnic differences and determinants of vitamin D deficiency in the UK Biobank. In INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 (pp. 227). OXFORD UNIV PRESS.
2021 Pham, K., Mulugeta, A., Zhou, A., O'Brien, J. T., Llewellyn, D. J., & Hypponen, E. (2021). Coffee, Brain Volume and Risk of Dementia and Stroke. In INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 (pp. 188). OXFORD UNIV PRESS.
WoS2
2021 Zhou, A., & Hypponen, E. (2021). Mendelian randomization on habitual coffee intake and plasma lipid profile: evidence from UK Biobank. In INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 (pp. 1 page). OXFORD UNIV PRESS.
2021 Lumsden, A., Mulugeta, A., Zhou, A., & Hypponen, E. (2021). Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK biobank. In INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 (pp. 145). OXFORD UNIV PRESS.
2018 Gibson, P. S., Wilson, L. R., Tripkovic, L., Hart, K. H., Johnsen, S., de Lusignan, S., . . . Lanham-New, S. A. (2018). Effectiveness of vitamin D fortification in raising serum 25-hydroxyvitamin D (25OHD) status in subjects with vitamin D deficiency (25OHD < 25 nmol/l): further analysis of the D2-D3 study population. In PROCEEDINGS OF THE NUTRITION SOCIETY Vol. 77 (pp. E14). CAMBRIDGE UNIV PRESS.
DOI
2018 Li, L., Williams, M., Johnston, K., Frith, P., Hypponen, E., & Paquet, C. (2018). PARENTAL RESPIRATORY DISEASE IS ASSOCIATED WITH REDUCED OFFSPRING LUNG HEALTH AT AGE 45 VIA PATHWAY OF MATERNAL AND PERSONAL SMOKING. In RESPIROLOGY Vol. 23 (pp. 75). WILEY.
2016 Wilson, L. R., Tripkovic, L., Hart, K., Smith, C. P., Bucca, G., Elliott, R., . . . Lanham-New, S. (2016). Mechanisms for differences in the efficacy of vitamin D2 and vitamin D3: assessment of post-supplementation decline in vitamin D status in the D2-D3 Study. In PROCEEDINGS OF THE NUTRITION SOCIETY Vol. 75 (pp. E116). CAMBRIDGE UNIV PRESS.
DOI WoS4
2015 Wilson, L., Hart, K., Elliott, R., Smith, C. P., Bucca, G., Penson, S., . . . Tripkovic, L. (2015). The D2-D3 Study: comparing the efficacy of 15μg/d vitamin D2 vs. D3 in raising vitamin D status in both South Asian and Caucasian women, and the ethical implications of placebo treatment. In PROCEEDINGS OF THE NUTRITION SOCIETY Vol. 74 (pp. E116). CAMBRIDGE UNIV PRESS.
DOI WoS3
2015 Tripkovic, L., Wilson, L., Hart, K., Elliott, R., Smith, C. P., Bucca, G., . . . Lanham-New, S. (2015). The D2-D3 Study: a randomised, double-blind, placebo-controlled food-fortification trial in women, comparing the efficacy of 15ug/d vitamin D2 vs vitamin D3 in raising serum 25OHD levels. In PROCEEDINGS OF THE NUTRITION SOCIETY Vol. 74 (pp. E16). CAMBRIDGE UNIV PRESS.
DOI WoS8
2014 Tripkovic, L., Wilson, L. R., Hart, K., Elliott, R., Smith, C. P., Bucca, G., . . . Lanham-New, S. (2014). DAILY SUPPLEMENTATION WITH VITAMIN D3 IS COMPREHENSIVELY MORE EFFECTIVE THAN VITAMIN D2 IN RAISING 25OHD STATUS AND CONCOMITANTLY REDUCING PARATHYROID HORMONE LEVELS: IMPLICATIONS FOR BONE HEALTH. In OSTEOPOROSIS INTERNATIONAL Vol. 25 (pp. S665). Birmingham, ENGLAND: SPRINGER LONDON LTD.
2012 Hypponen, E., Cavadino, A., & Williams, D. (2012). Vitamin D and Pre-Eclampsia: A Systematic Review and Meta-Analysis. In ANNALS OF NUTRITION AND METABOLISM Vol. 60 (pp. 137-138). KARGER.
WoS1
2011 Santhanakrishnan, V. K., Berry, D. J., Hingorani, A. D., Whittaker, J. C., Jarvelin, M. -R., & Hypponen, E. (2011). Obesity is a Causal Risk Factor For Low Vitamin D Status: A Bi-Directional Mendelian Randomization Study on 40,000 Individuals. In OBESITY Vol. 19 (pp. S231). FL, Orlando: NATURE PUBLISHING GROUP.
2011 Disanto, G., Ramagopalan, S., Morahan, J., Hypponen, E., Ebers, G., & Chaplin, G. (2011). Gestational Ultraviolet and Vitamin D Exposure and the Risk of Multiple Sclerosis in the United Kingdom. In NEUROLOGY Vol. 77 (pp. 198). HI, Honolulu: LIPPINCOTT WILLIAMS & WILKINS.
2008 Hattersley, A. T., Freathy, R. M., Bennett, A. I., Ring, S. M., Timpson, N. J., Pouta, A., . . . Frayling, T. M. (2008). Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight. In DIABETOLOGIA Vol. 51 (pp. S127-S128). SPRINGER.
WoS3
2006 Thomas, C., Hypponen, E., & Power, C. (2006). Effects of prenatal exposures on glucose metabolism in adulthood are mediated through adiposity. In EARLY HUMAN DEVELOPMENT Vol. 82 (pp. 562). ELSEVIER IRELAND LTD.
2005 Osterdal, M. L., Klemmensen, A., Tabor, A., Hypponen, E., Gillman, M. W., Knudsen, V., . . . Olsen, S. F. (2005). Preeclampsia risk in relation to vitamin D and calcium intake and to season of the year. In PEDIATRIC RESEARCH Vol. 58 (pp. 1120). CANADA, Toronto: INT PEDIATRIC RESEARCH FOUNDATION, INC.
1999 Virtanen, S., Laara, E., Hypponen, E., Reijonen, H., Rasanen, L., Aro, A., . . . Akerblom, H. K. (1999). Cow's milk consumption, HLA-DQB1 genotype and IDDM: a nested case-control study of siblings of children with diabetes. In DIABETES Vol. 48 (pp. A42-A43). AMER DIABETES ASSOC.
1997 Virtanen, S. M., Hypponen, E. T., Knip, M., Vahasalo, P., Kulmala, P., & Akerblom, H. K. (1997). Cow's milk consumption associated with disease specific autoantibodies in siblings of children with IDDM. In DIABETOLOGIA Vol. 40 (pp. 231). SPRINGER VERLAG.
  • Assessing the feasibility and laying the groundwork for applying the ‘recall by genotype’ design in MS research, Multiple Sclerosis Australia, 01/08/2025 - 31/07/2026

  • Predicting and Preventing Ovarian Cancer: a machine learning approach, MRFF- 2020 PHCRI - Primary Health Care Research, 01/06/2021 - 31/08/2025

  • Whole-genome multivariate reaction norm model for complex traits, ARC - Discovery Projects, 17/06/2019 - 16/06/2024

  • Machine learning to predict and prevent cancer, Tour de Cure Ltd, 01/07/2019 - 31/12/2022

  • The dark side of vitamin D supplementation, NHMRC - Project Grant, 01/01/2017 - 31/12/2022

  • Identifying pathways to dementia: a large scale genetic study, NHMRC - Project Grant, 01/01/2019 - 31/12/2021

Courses I teach

  • REHB 6014 Participatory Community Practice GE: Planning (2024)

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Applying modern epidemiological methods to optimise cancer prevention through physical activity Doctor of Philosophy Doctorate Full Time Mrs Honey Rahmanian
2024 Co-Supervisor Elucidating the genetic association between clozapine use and cardiometabolic dysfunction in treatment-resistant schizophrenia - Master Full Time Mr Rory Shepherd
2024 Principal Supervisor Investigating the shared genetic architecture of the five factor model personality traits and their relationship to psychopathology Doctor of Philosophy Doctorate Full Time Mr Liam Veltman
2023 Principal Supervisor Unraveling the link between blood proteins biomarkers and the risk of depression: a large-scale data-driven study Doctor of Philosophy Doctorate Full Time Mr Endeshaw Chekol Abebe
2023 Principal Supervisor Improving genetic prediction of ovarian cancer risk Doctor of Philosophy Doctorate Full Time Mr Melaku Anagaw
2022 Co-Supervisor Application of statistical genomic methods to tackle heterogeneity in psychiatric diseases Doctor of Philosophy Doctorate Full Time Miss Caitlin Doyle
2022 Co-Supervisor Dissecting the genetic and environmental factors affecting stunting  Doctor of Philosophy Doctorate Full Time Mr Reta Yimer
2022 Co-Supervisor Novel statistical genomics methods for disentangling genetic architecture and causal pathways in cardiometabolic traits Doctor of Philosophy Doctorate Full Time Lamessa Amente
2022 Principal Supervisor Machine learning to uncover predictors of adverse brain morphometry and Alzheimer's disease risk Doctor of Philosophy Doctorate Full Time Mr Yigizie Yeshaw Mihiretie
2017 Co-Supervisor  Translational clinical genomics and neurological disease (epilepsy) Master of Philosophy Master Part Time Ms Natasha Jane Radcliffe
  • Position: Professor of Nutritional and Genetic Epidemiology
  • Email: elina.hypponen@adelaide.edu.au
  • Alternative Contact: ACPreHAdministrative assistantt: +61 8 8302 1135 |e: acpreh@unisa.edu.au

Connect With Me

External Profiles

Other Links