Dr David Sharkey
NHMRC Postdoctoral Researcher (B)
School of Pharmacy and Biomedical Science
College of Health
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr David SharkeyPhD (Medicine), Discipline of Obstetrics and Gynaecology, The University of Adelaide.Thesis entitled: Seminal plasma regulation of the post-coital inflammatory response in the human cervix'Supervisors; Professor Sarah Robertson and Professor Robert Norman
David is an emerging research leader in the field of clinical reproductive immunology, currently serving as a senior research fellow at The University of Adelaide’s Robinson Research Institute and School of Biomedicine. After completing his PhD at the University of Adelaide in 2005 under the mentorship of Professors Sarah Robertson AO and Robert Norman AO, David has dedicated over two decades to advancing our understanding of how male seminal fluid interacts with the female immune system. His pioneering research has led to significant breakthroughs, including demonstrating that seminal fluid triggers an immune response in the female cervix post-coitus. As a chief investigator on recently awarded NHMRC Project and Ideas Grants, David is at the forefront of investigating the role of semen-derived factors in establishing the immune tolerance necessary for a successful pregnancy, solidifying his position as a key innovator and leader in this critical area of study.
| Date | Position | Institution name |
|---|---|---|
| 2025 - 2028 | Genea Human Research Ethics Committee | Genea |
| 2019 - ongoing | NHMRC Senior Research Associate | University of Adelaide |
| 2017 - 2017 | Robinson Researrch Institute Career Development Fellow | University of Adelaide |
| 2011 - 2016 | NHMRC Research Associate | University of Adelaide |
| 2010 - 2011 | Visiting Research Fellow | Louisiana State University Health Sciences Center New Orleans |
| 2005 - 2010 | Senior Postdoctoral Research Associate | University of Adelaide |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2015 | Achievement | High Performance Researcher Program | - | - | - |
| 2011 | Award | Travel award, Society for Reproduction and Fertility | - | - | - |
| 2011 | Award | Travel Award, Research Centre for Reproductive Health | University of Adelaide | - | $500 |
| 2010 | Award | Travel Award, Research Centre for Reproductive Health | University of Adelaide | - | - |
| 2010 | Achievement | Robinson Research Institute Mentor Program Training | - | - | - |
| 2009 | Achievement | Researcher Education and Development, Future Research Leaders Course | University of Adelaide | - | - |
| 2009 | Award | Travel Award, Research Centre for Reproductive Health | University of Adelaide | - | $295 |
| 2008 | Award | Overseas Conference Travel Award, Faculty of Health Sciences | University of Adelaide | - | $1000 |
| 2008 | Award | Travel Award, ARC / NHMRC Research Network in Genes and Environment in Development (NGED) | - | - | $1000 |
| 2008 | Award | Travel Award, Research Centre for Reproductive Health | University of Adelaide | - | $1000 |
| 2008 | Achievement | Higher Degree Research Supervisor Induction Course | University of Adelaide | - | - |
| 2008 | Achievement | Australian Society for Medical Research Professional Development Workshop | - | - | - |
| 2007 | Award | Travel Award, Research Centre for Reproductive Health | - | - | $1000 |
| 2007 | Award | Travel Award, ARC / NHMRC Research Network in Genes and Environment in Development (NGED) | - | - | $1000 |
| 2007 | Award | Overseas Conference Travel Award, Faculty of Health Sciences | University of Adelaide | - | $1500 |
| 2006 | Award | Travel Award, Society for Reproduction and Fertility (SRF) | - | - | £500 |
| 2004 | Scholarship | Postgraduate Travel Award, Faculty of Health Sciences Travel Scholarship | - | - | $1500 |
| 2003 | Award | Holden Young investigator Award | - | - | - |
| 2002 | Award | Junior Scientist Award | - | - | - |
| 2000 | Award | Student Poster Award | - | - | $250 |
| 2000 | Award | Travel Award, Australian Society for Medical Research | - | - | $150 |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2000 - 2005 | University of Adelaide | Australia | PhD |
| 1999 | University of Adelaide | Australia | Bachelor of Science (Honours) in Obstetrics and Gynaecology – First Class |
| Year | Citation |
|---|---|
| 2019 | How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success (2019). . Cambridge University Press. DOI |
| Year | Citation |
|---|---|
| 2023 | Moldenhauer, L. M., Linthwaite, S., Foyle, K. L., Sharkey, D. J., McCormack, C. D., Robertson, S. A., & Hull, M. L. (2023). Elevated Insulin and Insulin Resistance is Associated with Altered T Regulatory Cell Parameters in Women with Recurrent Miscarriage. In REPRODUCTIVE SCIENCES Vol. 30 (pp. 98A). Brisbane, AUSTRALIA: SPRINGER HEIDELBERG. |
| 2023 | Sharkey, D. J., & Robertson, S. A. (2023). The role of seminal plasma in supporting successful embryo implantation. In JOURNAL OF REPRODUCTIVE IMMUNOLOGY Vol. 158 (pp. 1 page). FRANCE, Paris: ELSEVIER IRELAND LTD. DOI WoS1 |
| 2023 | Sharkey, D. J., & Robertson, S. A. (2023). Seminal fluid and the female immune response - an update on the male contribution to pregnancy beyond fertilisation. In JOURNAL OF REPRODUCTIVE IMMUNOLOGY Vol. 159 (pp. 12-13). ELECTR NETWORK: ELSEVIER IRELAND LTD. DOI |
| 2008 | Sharkey, D., & Robertson, S. (2008). Follistatin mRNA expression is regulated by seminal fluid TGFβ in human Ect1 cervical epithelial cells. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 97-98). Kona, HI: SOC STUDY REPRODUCTION. DOI WoS1 |
| 2008 | Sharkey, D., & Robertson, S. (2008). Identification of TGFβ as a major active factor mediating seminal fluid signalling in human cervical epithelial cells. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 284). Kailua Kona, HI: SOC STUDY REPRODUCTION. DOI WoS1 |
| 1978 | GAY, C. V., SHARKEY, D. J., & SCHRAER, H. (1978). CARBONIC-ANHYDRASE LEVELS IN OSTEOCLAST-RICH BONE. In FEDERATION PROCEEDINGS Vol. 37 (pp. 272). FEDERATION AMER SOC EXP BIOL. WoS1 |
| Year | Citation |
|---|---|
| 2018 | Robertson, S. A., Sharkey, D. J., Tremellen, K. P., & Dekker, G. A. (2018). Interferon-G in seminal fluid - An 'anti-tolerance' signal in women?. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Aalborg, DENMARK: ELSEVIER IRELAND LTD. DOI |
| 2017 | Nadeau-Vallee, M., Chin, P. -Y., Belarbi, L., Brien, M. -E., Pundir, S., Beaudry-Richard, A., . . . Chemtob, S. (2017). Antenatal Suppression of Interleukin-1 Protects Against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Orlando, FL: SAGE PUBLICATIONS INC. |
| 2017 | Nadeau-Vallee, M., Chin, P. -Y., Belarbi, L., Brien, M. -E., Pundir, S., Berryer, M. H., . . . Chemtob, S. (2017). PROTECTIVE EFFECT OF A NOVEL NONCOMPETITIVE IL-1 RECEPTOR-BIASED LIGAND IN AN INFECTION-AND INFLAMMATION-INDUCED PRETERM BIRTH AS WELL AS IN FETAL INJURY AND DEVELOPMENTAL OUTCOMES. Poster session presented at the meeting of ACTA PAEDIATRICA. WILEY. |
| 2010 | Sharkey, D. J., & Robertson, S. A. (2010). TGFβ superfamily members BMP-15, GDF-9 and Activin A act as seminal fluid signalling agents in human cervical epithelial cells. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Cove, AUSTRALIA: ELSEVIER IRELAND LTD. DOI |
| 2010 | Sharkey, D. J., & Robertson, S. A. (2010). Sperm and seminal plasma differentially regulate cytokine and chemokine protein expression by human cervical epithelial cells. Poster session presented at the meeting of JOURNAL OF REPRODUCTIVE IMMUNOLOGY. Palm Cove, AUSTRALIA: ELSEVIER IRELAND LTD. DOI |
| Year | Citation |
|---|---|
| 2023 | Robertson, S., Rasi Ghaemi, S., Sharkey, D., McPherson, N., & Vasilev, K. (2023). PCT/AU2024/050764, SPERM SORTING DEVICE AND METHOD. Australia. |
| 2004 | Robertson, S., Sharkey, D., Tremellen, K., & Glynn, D. (2004). WO/2004/026333, Treatment and diagnosis of a reproductive disorder by measuring or inhibiting interferon-&gammad. Australia. |
| Year | Citation |
|---|---|
| - | Lyons, H., Arman, B., Robertson, S., & Sharkey, D. (n.d.). Supporting Dataset 1 from: Immune regulatory cytokines in seminal plasma of healthy men: A scoping review and analysis of variance. DOI |
| Year | Citation |
|---|---|
| - | Nisenblat, V., Sharkey, D., Wang, Z., Evans, S., HEALEY, M., Ohlsson-Teague, E. M. C., . . . Hull, L. (n.d.). Supplementary Material from: Plasma microRNAs display limited potential as diagnostic tools for endometriosis. DOI |
| Year | Citation |
|---|---|
| 2025 | Ghaemi, S. R., Sharkey, D. J., McPherson, N. O., Alemie, M. N., Vasilev, K., & Robertson, S. A. (2025). A surface-engineered microfluidic device for antibody-mediated negative selection of high-quality sperm for assisted reproduction. DOI |
Competitive Research Funding
| 2025-2028 |
NHMRC Ideas Grant Project: Sperm - a novel role in human reproduction beyond fertilisation APP2036636: Chief Investigator A (held with CIB Dr John Schjenken - University of Newcastle) |
AUD $1,781,257 |
| 2025-2027 |
NHMRC Development Grant Project: A functionalised surface device for spermatozoa selection in assisted reproductive medicine. APP039862: Chief Investigator D |
AUD $820,607 |
| 2024-2026 |
NHMRC Ideas Grant Project - Novel determinants of male fertility carried by seminal fluid extracellular vesicles APP2019934: Chief Investigator B (held with CIA - Dr John Schjenken: University of Newcastle) |
AUD $899,842 |
|
NHMRC Project Grant Project - The male partner contribution to pregnancy immune tolerance immune deficit in women. APP1139509: Chief Investigator E (held with CIA - Prof Sarah Robertson, CIB - Prof Kelton Tremellen, CIC- Prof Michelle Lane, CIE - Prof Simon Barry, and CIF - Prof Gus Dekker) |
$1,516,657 | |
| 2010 |
Recipient of Research Centre for Reproductive Health, Skills Competency Training Award Project: Influence of seminal fluid and Chlamydia trachomatis infection on endocervical
|
AUD $7,500 |
| 2009 | Recipient of inaugural Robinson Research Institute Early Career Research Grant Project: Is Activin A involved in the post-coital inflammatory response in the human cervix? |
AUD $10,000 |
| 2008 |
Recipient of Research Centre for Reproductive Health, Colin Matthews Early Career Research Grant Project: The post-coital inflammatory response in the human cervix: A potential role for Follistatin? |
AUD $10,000 |
Supervision of Research Students and teaching Experience
| 2022 - Present | Guest Lecturer - Research Spotlight Seminar: Principles of Human Health and Disease (PHHD) |
| 2011 - Present | Teaching of the “Data Management and Introduction to Laboratory Safety” and “Patenting Research - working through the process” tutorials into the Human Reproductive Health III, Research Project in Reproductive Health and Bachelor of Health Sciences Honours courses |
| 2005 - Present | Co-supervisor of Honours students from the Robinson Research Institute and School of Biomedicine |
| 2005 - Present | Supervision of Discipline of Obstetrics and Gynaecology Summer Vacation Research Scholars (4) |
| 2000 - 2004 | 1st and 2nd year Medical Tutor and Examiner - Problem Based Learning, Department of Medicine, The University of Adelaide |
| 2000 | Microbiology and Immunology practical course demonstrator and assessor for 2nd year Bachelor of Science students and 3rd year Medical students |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2024 | Co-Supervisor | Significance of impaired immune tolerance for infertility in men. | Doctor of Philosophy | Doctorate | Full Time | Ms Shreetha Ramasubramanian |
| 2024 | Co-Supervisor | Significance of impaired immune tolerance for infertility in men. | Doctor of Philosophy | Doctorate | Full Time | Ms Shreetha Ramasubramanian |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2020 - 2025 | Co-Supervisor | Functionalised surfaces for spermatozoa selection in assisted reproductive technologies (ARTs) | Doctor of Philosophy | Doctorate | Full Time | Mrs Soraya Rasi Ghaemi |
| Date | Role | Research Topic | Location | Program | Supervision Type | Student Load | Student Name |
|---|---|---|---|---|---|---|---|
| 2023 - ongoing | External Supervisor | Novel determinants of male infertility carried by seminal plasma extracellular vesicles | University of Newcastle | - | Doctorate | Full Time | Dr Elizabeth Torres Arce |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2022 - 2025 | Council | Society for Reproductive Biology Council | Society for Reproductive Biology | Australia |
| 2019 - ongoing | Secretary | Society for Reproductive Biology Council | Society for Reproductive Biology | Australia |
| 2019 - ongoing | Member | New Frontiers For A Healthy Start To Life Organising Committee | Robinson Research Institute, The University of Adelaide | Australia |
| 2018 - ongoing | Member | American Society for Reproductive Immunology Program Organising Committee | American Society for Reproductive Immunology | United States |
| 2015 - 2016 | Member | Adelaide Medical and Nursing School – Look and Feel Workgroup | - | - |
| 2010 - 2013 | Member | School of Paediatrics and Reproductive Health – IP and Commercialisation Committee | - | - |
| 2010 - 2012 | Co-Chair | School of Paediatrics and Reproductive Health Research Seminar Series | - | - |
| 2008 - 2012 | Co-Chair | Robinson Research Institute ECR / MCR Professional Development Program | - | - |
| 2008 - ongoing | Member | Australian Society for Medical Research | - | - |
| 2007 - 2012 | Representative | School of Paediatrics and Reproductive Health, Research Committee | - | - |
| 2007 - 2012 | Representative | School of Paediatrics and Reproductive Health | - | - |
| 2007 - 2012 | Representative | Discipline of Obstetrics and Gynaecology | - | - |
| 2000 - 2002 | Member | Australian Society for Medical Research | - | - |