APrf David Parsons
School of Medicine
College of Health
Associate Professor David Parsons, Chief Medical Scientist. Associate Professor David Parsons was the leader of the Cystic Fibrosis Stream at the Children's Research Centre and was Chief Medical Scientist in the Department of Respiratory And Sleep Medicine at the Women's and Children's Hospital. He was Head of the Adelaide Cystic Fibrosis Research Group at the Robinson Institute, and an Affiliate Senior Lecturer in the Discipline of Paediatrics at the University of Adelaide.Associate Professor David Parsons devoted the past 35 years to finding a cure for Cystic Fibrosis (CF) airway disease. He has twice-won Service Excellence Awards administered by the Women's and Children's Health Network for his innovations in CF and respiratory related fields. He is a Fellow of the ANZSRS. He and his research team have pioneered a ground-breaking gene therapy technique that has been successful in reversing the basic cellular defect that causes CF in mouse models, and that holds promise as a long-lasting treatment for CF lung disease. He was also responsible for initiating and championing leading-edge research into the surface behaviour of airways in health and disease using non-invasive synchrotron X-ray imaging techniques. By measuring the ASL and microscopic particles previously considered too small to view in living animal-model airways, David pioneered new and more effective ways of measuring the success of respiratory treatments like gene therapy in CF patients. He worked closely with Andreas Fouras, now CEO of the Australian X-ray imaging company 4DMedical Pty Ltd, to bring the use of X-ray velocimetry to the assessment of lung health in animal models, a technique now in paediatric clinical trials. He was one of the 5 researchers awarded the 2023 Eureka Prize for Excellence in Interdisciplinary Research.David's development of CF airway gene transfer methods were supported initially by the USA CF Foundation, and evolved to attract regular funding from the National Health and Medical Research Council in Australia, and from the Medical Research Future Fund (MRFF).
Research
Since the mid 1990's I have been developing airway gene transfer methods to achieve a safe and effective treatment or cure for clinical use for the lung disease of cystic fibrosis. I have led the Adelaide CF Airway Gene Therapy group since establishing it in 1997. My establishment of reliable and effective in-vivo airway gene vector dosing and gene expression measurement has been coupled with developing effective, rapid and non-invasive measurement of airway health in CF airways using synchrotron and other X-rays along with other in-vivo imaging such as bio-photonic techniques based on luciferase gene transfer.
My interest and expertise covers three themes:
(1) Development of novel analysis methods with potentially wide applicability. Starting with novel measurements of single-neuron activity in the Aplysia animal model in-vivo (Science 221, 1203-, 1983), I have championed development of synchrotron X-ray imaging to investigate animal airway health and physiology in-vivo.
(2) Enablement of practical advances in medical therapy with potentially fundamental value, demonstrated by the >30 years efforts in development of airway gene transfer for treatment or cure of CF airway disease. This theme advanced into the translational preclinical arena with trials of airway gene transfer in a non-human primate lung model.
(3) The last theme is the fostering of new and often cross-discipline collaborations, local and worldwide. My expansion into synchrotron X-ray physics to develop new airway health outcome measurements, based at the Japanese SPring-8 synchrotron, accompanied the provision of rodent animal model studies that formed the basis of X-ray velocimetry, now a well-accepted new method for assessing ventilation in all parts of the lung in animals and humans.
I have continually supervised Honors and PhD students to foster their research careers, and I played a key role in establishing a community-based research Foundation (www.cure4cf.org) that supplemented and supported the continuity, resilience, and bridging-salary needs of our CF airway gene therapy research program in the 2010's.
| Date | Position | Institution name |
|---|---|---|
| 2008 - 2025 | Chief Medical Scientist | Women's and Children's Hospital, Adelaide |
| 2001 - ongoing | Affiliate Senior Lecturer | University of Adelaide, Adelaide |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2012 | Award | Research Medal | Australian and New Zealand Society of Respiratory Scientists | - | - |
| 2012 | Fellowship | Fellow (designation: FANZSRS) | Australia and New Zealand Society of Respiratory Scientists | - | - |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1977 - 1981 | University of Melbourne | Australia | PhD |
| 1976 - 1976 | University of Melbourne | Australia | BSc(Hons) |
| 1971 - 1973 | University of Melbourne, Melbourne | Australia | BSc (Information & Computer Science) |
| Date | Title | Institution name | Country |
|---|---|---|---|
| 2016 | FANZSRS | Australian and New Zealand Society of Respiratory Scientists | Australia |
| Year | Citation |
|---|---|
| 2026 | Donnelley, M., Tai, A., Carson-Chahhoud, K., Parsons, D., Dharmaprani, D., Smith, R., . . . Phillips, J. (2026). PAEDIATRIC X-RAY VELOCIMETRY LUNG VENTILATION IMAGING: UPDATES AND FUTURE PLANS. In INTERNAL MEDICINE JOURNAL Vol. 56 (pp. 106-107). WILEY. |
| 2025 | Hart, S., Dodge, R., Hogstrom, K., Parsons, D., Kahre, K., Soriano, M. M., . . . Ream, J. (2025). Highlights of the Psyche Environmental Assurance Program. In 2025 IEEE AEROSPACE CONFERENCE (pp. 12 pages). MT, Big Sky: IEEE. DOI |
| 2025 | Li, R., Nguyen, N., Salcedo, E., Phillips, E., Su, F. -C., Domal, S., . . . Desai, N. (2025). Enabling 68Ga-PSMA-11 (Illuccix)-response Adapted SAbR for High-Risk Prostate Cancer Using MR-and CBCT-Based Online Adaptive Systems (NCT06044857). In RADIOTHERAPY AND ONCOLOGY Vol. 206 (pp. S3129-S3130). ELSEVIER IRELAND LTD. |
| 2025 | Lin, C. -S., Lin, M. -H., Visak, J., Wandrey, N., Arbab, M., Alluri, P., . . . Parsons, D. (2025). AI-Enhanced Optimization for kV-CBCT Guided Online Adaptive Radiotherapy in Hypofractionated Whole Breast Treatment. In RADIOTHERAPY AND ONCOLOGY Vol. 206 (pp. S3162-S3163). ELSEVIER IRELAND LTD. |
| 2025 | Lin, M. -H., Liao, C. -Y., Yarlagadda, P., Domal, S., Parsons, D., Wang, J., . . . Sher, D. (2025). Intrafraction Motion and Margin Assessment for CBCT-Guided Online Adaptive Radiotherapy in Head and Neck Cancer. In RADIOTHERAPY AND ONCOLOGY Vol. 206 (pp. S3339-s3340). ELSEVIER IRELAND LTD. |
| 2024 | Schneider-Futschik, E., Li, D., Donnelly, M., Parsons, D., & Habgood, M. (2024). Fetal drug exposure after maternally administered CFTR modulators Elexacaftor/Tezacaftor/ Ivacaftor in a rat model. In RESPIROLOGY Vol. 29 (pp. 58). WILEY. |
| 2024 | Reyne, N., Cmielewski, P., Smith, R., Eikelis, N., Nilsen, K., Mall, M., . . . Donnelley, M. (2024). X-ray Velocimetry detects peripheral lung ventilation defects in ßENaC mice. In RESPIROLOGY Vol. 29 (pp. 166). WILEY. |
| 2024 | Bruorton, M., Carson-Chahhoud, K., Donnelley, M., Goddard, T., O'Connor, A., Parsons, D., . . . Tai, A. (2024). Feasibility study of x-ray Velocimetry imaging in children with CF. In RESPIROLOGY Vol. 29 (pp. 225). WILEY. |
| 2022 | Drysdale, V., Cmielewski, P., Donnelley, M., Parsons, D., Reyne, N., & McCarron, A. (2022). Miniature Devices for Controlled Airway Surface Perturbation in Rats: Which Device Produces the Best Lentiviral Vector Gene Transfer?. In MOLECULAR THERAPY Vol. 30 (pp. 284). CELL PRESS. |
| 2022 | Donnelley, M., Cmielewski, P., Morgan, K., Delhove, J., Reyne, N., McCarron, A., . . . Parsons, D. (2022). In Vivo Lentiviral Gene Transfer to Airway Surfaces for Cystic Fibrosis is Improved by Magnetic Guidance of Particles. In MOLECULAR THERAPY Vol. 30 (pp. 421). CELL PRESS. |
| 2021 | Jayapal, M., Tran H, B., Maiolo, S., Reynolds, P., Liu, H., Parsons, D., . . . Hodge, S. (2021). PYOCYANIN INCREASES VASCULAR RAC1/ZIP12/BMPR2-RELEVANCE TO VASCULAR DYSFUNCTION AND REMODELLING IN CYSTIC FIBROSIS. In RESPIROLOGY Vol. 26 (pp. 59). WILEY. |
| 2021 | Donnelly, M., Christou, C., Finnie, J., Dustng, J., Khanlou, S., Fouras, A., & Parsons, D. (2021). DETECTION OF LOCALLY-ALTERED AIRFLOW BY X-RAY VELOCIMETRY (XV) IN PIGS FOR ARDS-LIKE DISEASE MODELLING OF COVID-19 LUNG INJURY. In RESPIROLOGY Vol. 26 (pp. 30). WILEY. |
| 2021 | Reyne, N., Cmielewski, P., McCarron, A., Parsons, D., & Donnelley, M. (2021). Lentiviral Airway Gene Therapy Correction of CFTR Function in Knockout Cystic Fibrosis Rats. In MOLECULAR THERAPY Vol. 29 (pp. 259). CELL PRESS. |
| 2021 | Reyne, N., Cmielewski, P., Mccarron, A., Parsons, D., & Donnelley, M. (2021). LENTIVIRAL AIRWAY GENE-ADDITION CORRECTS CF RAT NASAL ION CHANNEL FUNCTION. In RESPIROLOGY Vol. 26 (pp. 156). WILEY. |
| 2019 | Gardner, M., Donnelley, M., Parsons, D., Morgan, K., McCarron, A., & Cmielewski, P. (2019). Neural Networks provide superior detection of particles in Synchrotron X-ray images for automated Mucociliary Transport measurement. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). online: IEEE. |
| 2019 | McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. In MOLECULAR THERAPY Vol. 27 (pp. 209). Washington, DC: CELL PRESS. |
| 2019 | Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. W. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers. DOI Scopus1 |
| 2019 | Li, J., Quirk, B. C., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. A. (2019). Imaging genetically-modified cells with a miniaturised multimodal optical coherence tomography + fluorescence probem. In Proceedings of the 2019 IEEE Photonics Conference (IPC) (pp. 1-2). Piscataway, NJ: IEEE. DOI Scopus1 WoS1 |
| 2019 | Hopkins, R., Parsons, D., Huang, C., Lichtenstein, D. R., & Jacobson, B. C. (2019). WE'RE CANCELLING TOO MANY PATIENTS IN TRIAGE: A QI PROJECT EXAMINING THE PRACTICE OF CANCELLING COLONOSCOPIES DUE TO ANTICIPATED INADEQUATE BOWEL PREPARATION. In GASTROINTESTINAL ENDOSCOPY Vol. 89 (pp. AB155-AB156). CA, San Diego: MOSBY-ELSEVIER. DOI |
| 2019 | Parsons, D., Cmielewski, P., Mccarron, A., Mcintyre, C., Craig, F., Finnie, J., . . . Donnelley, M. (2019). Update on the Australian cystic fibrosis rat colony. In Respirology Vol. 24 (pp. 136). Broadbeach, Qld.: Wiley. |
| 2019 | Macowan, M., Tran, H., Matthews, K., Ralph, M., Donnelley, M., Parsons, D., & Hodge, S. (2019). DYSREGULATED S1P SIGNALLING IN MOUSE MODEL OF CYSTIC FIBROSIS-LIKE LUNG DISEASE PRODUCED BY βENAC OVEREXPRESSION. In RESPIROLOGY Vol. 24 (pp. 118). WILEY. |
| 2018 | Gradl, R., Dierolf, M., Hehn, L., Gunther, B., Kutschke, D., Yang, L., . . . Morgan, K. (2018). Dynamic x-ray imaging at the Munich Compact Light Source. In Microscopy and Microanalysis Vol. 24 (pp. 350-351). Saskatoon, Canada: MIcroscopy Society of America. DOI |
| 2017 | Jung, H., Lee, I., Lee, S., Parsons, D., & Donnelley, M. (2017). Multiple mucociliary transit marker tracking in synchrotron X-ray images using the global nearest neighbor method. In Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC' 17) Vol. 2017 (pp. 1824-1827). Online: IEEE. DOI Scopus2 WoS3 |
| 2016 | McCarron, A., McIntyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2016). Development of a Clinically-Acceptable Lentiviral Vector for Cystic Fibrosis Airway Gene Therapy. In MOLECULAR THERAPY Vol. 24 (pp. S280-S281). Washington, DC: NATURE PUBLISHING GROUP. DOI |
| 2016 | Donnelley, M., Morgan, K., Farrow, N., Siu, K., & Parsons, D. (2016). Non-invasive airway health measurement using synchrotron X-ray microscopy of high refractive index glass microbeads. In M. D. DeJonge, D. J. Paterson, & C. G. Ryan (Eds.), Aip Conference Proceedings Vol. 1696 (pp. 4 pages). Australian Synchrotron, Melbourne, AUSTRALIA: AMER INST PHYSICS. DOI Scopus8 WoS6 |
| 2016 | Parsons, D., & Robar, J. (2016). Continuous Intra-Fractional Monitoring of the Prostate Using Dynamic KV Collimation and Tube Current Modulation. In MEDICAL PHYSICS Vol. 43 (pp. 3684). Washington, DC: WILEY. DOI |
| 2012 | Morgan, K., Paganin, D., Parsons, D., Donnelly, M., Yagi, N., Uesugi, K., . . . Siu, K. (2012). Single grating x-ray imaging for dynamic biological systems. In International Workshop on X-Ray and Neutron Phase Imaging with Gratings Vol. 1466 (pp. 124-129). United States: Springer New York LLC. DOI Scopus3 WoS3 |
| 2010 | Donnelley, M., Parsons, D., Morgan, K., & Siu, K. (2010). Animals In synchrotrons: overcoming challenges for high-resolution, live, small-animal imaging. In K. Siu (Ed.), Proceedings of 6th International Conference on Medical Applications of Synchrotron Radiation Vol. 1266 (pp. 30-34). United States: American Institute of Physics. DOI Scopus19 WoS14 |
| 2009 | Morgan, K., Paganin, D., Parsons, D., Donnelley, M., Yagi, N., Uesugi, K., . . . Siu, K. (2009). Optimising coherence properties for phase contrast x-Ray imaging (PCXI) to reveal airway surface liquid (ASL) as an airway health measure. In Ifmbe Proceedings Vol. 25 (pp. 135-138). Munich, Germany: Springer Verlag. DOI Scopus2 WoS2 |
| 2009 | Cmielewski, P. L., Anson, D. S., & Parsons, D. W. (2009). Six Months Lentiviral Correction of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Defect in Cystic Fibrosis Mice. In MOLECULAR THERAPY Vol. 17 (pp. S122). San Diego, CA: NATURE PUBLISHING GROUP. |
| 2007 | Kremer, K., Anson, D., & Parsons, D. (2007). Inhibition of the innate immune response to lentivirus mediated gene transfer with leptomycin B. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 530). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. |
| 2007 | Buckley, S., Howe, S., Sheard, V., Anson, D., Parsons, D., Thrasher, A., . . . McKay, T. (2007). Significant airway transduction after <i>in utero</i> administration of a gp64 pseudotyped lentiviral vector. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 526). Shine Dome Acad Sci, Canberra, AUSTRALIA: WILEY-BLACKWELL. DOI |
| 2007 | Parsons, D., Siu, K., Williams, I., Boucher, R., Uesugi, K., & Yagi, N. (2007). Non-invasive X-ray imaging of mouse airways and organs at very high resolution - A new option for gene expression studies?. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 531-532). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. |
| 2007 | Liu, C., Wong, E., Tan, C. K., Anson, D., & Parsons, D. (2007). Effects of LPC pre-dosing on lentiviral gene expression in mouse lung. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 538). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. |
| 2005 | Cmielewski, P., Parsons, D. W., Stocker, A., & Anson, D. S. (2005). <i>In vivo</i> airway conditioning for improved gene delivery:: Mucosubstance release and lentiviral gene transfer. In JOURNAL OF GENE MEDICINE Vol. 7 (pp. 1135). Melbourne, AUSTRALIA: JOHN WILEY & SONS LTD. |
| 2005 | Quirchmayr, G. (2005). Business continuity management. In The 6th Winter School European Intensive Programme on Information Security Mangement and Technology (pp. 81-91). ROUTLEDGE. |
| Year | Citation |
|---|---|
| 2024 | Parsons, D., Bruorton, M., Phillips, J., Eikelis, N., Nilsen, K., Carson-Chahoud, K., . . . Goddard, T. (2024). Lung ventilation via x-ray velocimetry imaging and PFTs in CF children: Case-studies from the ongoing Adelaide pilot and feasibility trial. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science (TSANZSRS 2024), as published in Respirology. Gold Coast Convention and Exhibition Centre, Gold Coast, QLD: Wiley. DOI |
| 2023 | Roff, A. J., Robinson, J. L., Hammond, S. J., Davies, A., Clifton, V. L., Wallace, M. J., . . . Donnelley, M. (2023). X-ray Velocimetry Detects Changes in Local Airflow in a Sheep Model of Asthma During Pregnancy. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Germany: SPRINGER HEIDELBERG. |
| 2023 | Rout-Pitt, N., Mc Carron, A., Boog, B., Parsons, D., & Donnelley, M. (2023). A twist in the cystic fibrosis story—TGF-β1 treatment affects epithelialmesenchymal transition differentially in two cystic fibrosis rat airway cell models. Poster session presented at the meeting of North American Cystic Fibrosis Conference. |
| 2023 | Li, D., Habgood, M., Reyne, N., Cmielewski, P., McCarron, A., Parsons, D., . . . Schneider-Futschik, E. (2023). Cystic fibrosis modulator triple combination in pregnancy and lactation: Effects on the developing lung, gut and pancreas. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science (TSANZSRS, 2023) as published in Respirology. Christchurch, Aotearoa New Zealand: Wiley. DOI |
| 2022 | Reyne, N., Cmielewski, P., Boog, B., McCarron, A., Parsons, D., & Donnelley, M. (2022). Cystic fibrosis rat models demonstrate altered respiratory mechanics. Poster session presented at the meeting of Abstracts of the The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ), Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science (TSANZSRS, 2022), as published in Respirology. virtual online: Wiley. DOI |
| 2021 | Tran, H., Jayapal, M., Donnelley, M., Parsons, D., & Parsons, D. (2021). MECHANISMS LEADING TO PULMONARY VASCULAR DISORDERS MAY ARISE BEFORE FULL PENETRATION OF LUNG DISEASE IN CF RATS. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2020 | Carpentieri, C. L., Cmielewski, P., McCarron, A., Reyne, N., Boog, B., Farrow, N., . . . Parsons, D. (2020). ACUTE PSEUDOMONAS AERUGINOSA INFECTION IN WILD-TYPE AND PHE508DEL CF RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2020 | Rout-Pitt, N., Delhove, J., Farrow, N., Donnelley, M., & Parsons, D. (2020). Development of an Epithelial Mesenchymal Transition Tracing Vector. Poster session presented at the meeting of MOLECULAR THERAPY. ELECTR NETWORK: CELL PRESS. |
| 2020 | Carpentieri, C., Farrow, N., Cmielewski, P., Delhove, J., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2020). Frequency and Timing of Lentiviral Vector Repeat Dose Delivery Does Not Significantly Alter Long-Term Transgene Expression Levels in Mouse Lungs. Poster session presented at the meeting of MOLECULAR THERAPY. ELECTR NETWORK: CELL PRESS. |
| 2020 | Reyne, N., Cmielewski, P., McCarron, A., Parsons, D., & Donnelley, M. (2020). Measuring CFTR Function in CF Rats: Optimisation of the Nasal Potential Difference Technique. Poster session presented at the meeting of Abstracts of the the 34th Annual North American Cystic Fibrosis Conference (NACFC 2020), as published in Pediatric Pulmonology. Phoenix, Arizona and virtual online: Wiley. DOI |
| 2020 | Delhove, J., Donnelley, M., & Parsons, D. (2020). ENGINEERING IMMUNE STEALTH, STEM CELL-TARGETING LENTIVIRAL VECTORS FOR CYSTIC FIBROSIS GENE THERAPY. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2020 | McCarron, A., Farrow, N., Cmielewski, P., Reyne, N., Parsons, D., & Donnelley, M. (2020). AIRWAY GENE-ADDITION THERAPY FOR CF LUNG DISEASE: STRATEGIES FOR IMPROVING GENE TRANSFER EFFICACY AND LONGEVITY. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2020 | Dusting, J., Donnelley, M., Parsons, D., & Fouras, A. (2020). DEDICATED XV HUMAN SCANNER DELIVERING 4D REGIONAL LUNG FUNCTION ANALYSIS WITH A LOWER DOSE THAN CHEST X-RAY. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2020 | Delhove, J., Donnelley, M., & Parsons, D. (2020). Generation of Immune Resistant, Stem Cell Targeting Lentivirus for Cystic Fibrosis Airway Gene Therapy. Poster session presented at the meeting of MOLECULAR THERAPY. ELECTR NETWORK: CELL PRESS. |
| 2019 | Farrow, N., Carpentieri, C., Delhove, J., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2019). ASSESSING LENTIVIRAL VECTOR RE-DOSING SCHEDULES FOR IMPROVED AND SUSTAINED TRANSGENE EXPRESSION. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2019 | Tran, H. B., Macowan, M., Abdo, A., Donnelley, M., Parsons, D., & Hodge, S. (2019). Airway inflammasome activation and dysregulated S1P signalling associated with mucus obstruction in a cystic fibrosis-like mouse model.. Poster session presented at the meeting of Respirology. Wiley. |
| 2019 | Cmielewski, P., McCarron, A., Reyne, N., Finnie, J., Rout-Pitt, N., Schjenken, J., . . . Donnelley, M. (2019). AN UPDATE ON THE PHENOTYPE CHARACTERISATION OF PHE508DEL AND CFTR KNOCKOUT RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2019 | Werdiger, F., Morgan, K. S., Dusbky, S., Cmielewski, P., Kitchen, M., Klein, M., . . . Donnelley, M. (2019). Quantification of local lung disease in rat models of CF disease and CF knockout mice. Poster session presented at the meeting of Pediatric Pulmonology. Nashville, Tennessee: Wiley. |
| 2019 | Rout-Pitt, N., Donnelley, M., & Parsons, D. (2019). OPTIMISATION OF BRONCHOSCOPIC LENTIVIRAL VECTOR DELIVERY FOR DIRECT LOBE TARGETING IN RAT LUNGS. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2018 | Werdiger, F., Donnelley, M., Parsons, D., Morgan, K. S., Samarage, C. R., Carnibella, R., & Fouras, A. (2018). QUANTIFICATION OF REGIONAL LUNG DISEASE IN β-ENAC MICE USING A LABORATORY X-RAY SOURCE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2018 | McIntyre, C., Rout-Pitt, N., Donnelley, M., & Parsons, D. (2018). LOBE SPECIFIC TARGETING OF LENTIVIRAL VECTOR GENE TRANSFER TO THE LUNGS OF ADULT RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2018 | McIntyre, C., Cmielewski, P., Craig, F., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). CF-RELATED PATHOLOGIES ARE MORE SEVERE IN KNOCKOUT RATS COMPARED TO PHE508DEL RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2018 | Donnelley, M., Klein, M., Hausermann, D., Hall, C., Maksimenko, A., Morgan, K., & Parsons, D. (2018). Non-invasive mucociliary transit assessment in live pig trachea. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Adelaide, Australia: Wiley. DOI |
| 2018 | Mcintyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2018). GENERATION OF NEW CYSTIC FIBROSIS RAT MODELS IN AUSTRALIA. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2018 | Carpentieri, C., Farrow, N., Mcintyre, C., Cmielewski, P., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS FOR CYSTIC FIBROSIS AIRWAY GENE THERAPY. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2018 | Farrow, N., Cmielewski, P., Donnelley, M., Bertoncello, I., & Parsons, D. (2018). DOES EPITHELIAL ABLATION IN THE NASAL AIRWAYS OF MICE IMPROVE STEM CELL ENGRAFTMENT?. Poster session presented at the meeting of RESPIROLOGY. WILEY. |
| 2018 | Donnelley, M., & Parsons, D. (2018). HOW DO WE KNOW IF CYSTIC FIBROSIS LUNG GENE THERAPY WORKS? THE IMPORTANCE OF THE RIGHT ANIMAL MODEL, AND THE RIGHT MEASUREMENT METHOD. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY. |
| 2018 | Carpentieri, C., Farrow, N., Cmielewski, P., McIntyre, C., McCarron, A., Rout-Pitt, N., . . . Donnelley, M. (2018). Airway Gene-Addition Therapy for Cystic Fibrosis: the VSV-G Pseudotype Produces Higher Transduction Levels Than HA. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. |
| 2018 | Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Bertoncello, I., & Parsons, D. (2018). Epithelial Disruption Enables Human Airway Stem Cell Transplantation in Mouse Nasal Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. |
| 2017 | Farrow, N., Donnelley, M., McIntyre, C., Rout-Pitt, N., & Parsons, D. (2017). Developing high efficiency gene transfer techniques using human air liquid interface cultures. Poster session presented at the meeting of TSANZ Poster presentations, as published in Respirology. Canberra: Wiley. |
| 2017 | McIntyre, C., Donnelley, M., Cmielewski, P., & David, P. W. (2017). Generation of new cystic fibrosis rat models in Australia developed using CRISPR/Cas9 genome editing. Poster session presented at the meeting of Pediatric Pulmonology. Indianapolis, Indiana: Wiley. DOI WoS1 |
| 2017 | McCarron, A., Rout-Pitt, N., McIntyre, C., Donnelley, M., & Parsons, D. W. D. (2017). Lentivirus Production in Stirred-Tank and Packed-Bed Basket Bioreactor Systems: A Comparison. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. |
| 2017 | Farrow, N., Donnelley, M., Rout-Pitt, N., McIntyre, C., Bertoncello, I., & Parsons, D. W. D. (2017). High Efficiency <i>In Vitro</i> Transduction of Human Airway Basal Cells. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. |
| 2017 | Farrow, N., Cmielewski, P., Donnelley, M., & Parsons, D. (2017). HIGH EFFICIENCY LENTIVIRAL HUMAN AIRWAY BASAL CELL TRANSDUCTION. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2017 | Carpentieri, C. L., Farrow, N., McIntyre, C., McCarron, A., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2017). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS DEVELOPED FOR TREATING CYSTIC FIBROSIS LUNG DISEASE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. |
| 2017 | Werdiger, F., Murrie, R., Kitchen, M., Samarage, C., Carnibella, R., Fouras, A., . . . Parsons, D. (2017). Detection of regional lung disease in β-ENaC mice on a laboratory x-ray source. Poster session presented at the meeting of Abstracts of the 31st Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Indianapolis, Indiana: Wiley-Blackwell. DOI |
| 2016 | Donnelley, M., Morgan, K., & Parsons, D. W. (2016). DIRECT X-RAY MEASUREMENT OF AIRWAY SURFACE HEALTH IN ANIMAL MODELS: AN UPDATE ON THE STATE-OF-THE-ART. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2016 | Cmielewski, P., & Parsons, D. W. (2016). RAPID IN VIVO NASAL TRANSEPITHELIAL POTENTIAL DIFFERENCE MEASUREMENT IN MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2015 | Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V., . . . Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | McIntyre, C., Craig, F., Cmielewski, P., Donnelley, M., Farrow, N., & Parsons, D. (2015). Comparing the Efficacy of Tat-Dependent and Tat-Independent Lentiviral Vectors. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP. DOI |
| 2015 | Devereux, S., Cmielewski, P., Farrow, N., & Parsons, D. (2015). Airway Pre-Treatment Enhances Mouse Lung Lentiviral Reporter Gene Expression. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP. DOI |
| 2015 | Kicic, A., Ling, K., Martinovich, K., Garratt, L. W., Looi, K., Kicic-Starcevich, E., . . . Moodley, Y. (2015). CORRECTIVE EFFECTS ON AIRWAY EPITHELIAL FUNCTION BY HUMAN AMNIOTIC EPITHELIAL CELLS (HAEC) WHEN TREATING CYSTIC FIBROSIS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2015 | Farrow, N. R., McQualter, J., Donnelley, M., Cmielewski, P., Bertoncello, I., & Parsons, D. (2015). CYSTIC FIBROSIS MOUSE MODELS DISPLAY AGE DEPENDENT AIRWAY STEM/PROGENITOR CELL HYPERPLASIA. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2015 | Cmielewski, P., Parsons, D., Donnelley, M., Padmanabhan, H., Ling, K., Stick, S. M., . . . Moodley, Y. (2015). DELIVERY OF HUMAN AMNIOTIC STEM CELLS CORRECTS CFTR FUNCTION IN CF MOUSE NASAL AIRWAYS IN VIVO. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2014 | Farrow, N. R., McQualter, J. L., Donnelley, M., Bertoncello, I., & Parsons, D. W. (2014). GENE THERAPY FOR CF: IS LONG TERM EXPRESSION A CONSEQUENCE OF TRANSDUCING CONDUCTING AIRWAY ENDOGENOUS RESPIRATORY STEM CELLS?. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2014 | Padmanabhan, H., Cmielewski, P., Donnelley, M., & Parsons, D. (2014). IMPROVING THE TRANSDUCTION EFFICIENCY OF AN AEROSOL DELIVERED LENTIVIRAL VECTOR FOR CYSTIC FIBROSIS LUNG GENE THERAPY. Poster session presented at the meeting of JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. MARY ANN LIEBERT, INC. |
| 2014 | Stahr, C. S., Samarage, C. R., Parsons, D. W., Dubsky, S., Donnelley, M., Thurgood, J., . . . Fouras, A. (2014). Regional Image Based Pulmonary Function Testing Detects Cf Lung Disease Earlier Than Conventional Pft. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. |
| 2014 | Cmielewski, P., Farrow, N., McIntyre, C., Padmanabhan, H., Donnelley, M., Kuchel, T., & Parsons, D. W. (2014). Lentiviral Airway Gene Transfer in Normal Ferrets. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: NATURE PUBLISHING GROUP. |
| 2013 | Cmielewski, P., & Parsons, D. W. (2013). CF mouse survival is improved by airway lentiviral CFTR gene transfer. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell. DOI |
| 2013 | Farrow, N., McQualter, J., Parsons, D., & Bertoncello, I. (2013). Endogenous stem/progenitor cell compartments of conducting airways differ in cystic fibrosis and normal mice. Poster session presented at the meeting of HUMAN GENE THERAPY. Univ London, Royal Holloway, Egham, ENGLAND: MARY ANN LIEBERT INC. |
| 2013 | Morgan, K., Donnelley, M., Fouras, A., Siu, K., & Parsons, D. (2013). Changes in airway surface liquid depth imaged after aerosolized hypertonic saline. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell. DOI |
| 2013 | Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N., Chua, C., Fouras, A., & Parsons, D. (2013). In-vivo changes in mucociliary transport after aerosols. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell. DOI |
| 2012 | Morgan, K. S., Donnelley, M., Fouras, A., Parsons, D., & Siu, K. (2012). SYNCHROTRON PHASE CONTRAST X-RAY IMAGING CAN DETECT AIRWAY SURFACE LIQUID DEPTH CHANGES FOLLOWING AEROSOLISED HYPERTONIC SALINE TREATMENT. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2012 | Siu, K., Chua, C. S., Donnelley, M., Morgan, K. S., Farrow, N., Mall, M. A., . . . Fouras, A. (2012). REGIONAL MEASURES OF LUNG FUNCTION IN THE β-ENAC MOUSE OBTAINED USING X-RAY IMAGING VELOCIMETRY. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2012 | Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). Distribution, dynamics and variability of fluid doses into live mouse lungs is revealed using high resolution synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 2012 Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meetings, as published in Respirology. Canberra, Australia: Wiley-Blackwell. DOI |
| 2012 | Parsons, D., Karen, S., Kaye, M., & Donnelley, M. (2012). High Speed X-Ray Imaging Reveals Dosed Fluid Dynamics and Fate in Mouse Nasal and Lung Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Philadelphia, PA: NATURE PUBLISHING GROUP. |
| 2012 | Cmielewski, P., & Parsons, D. W. (2012). AIRWAY LENTIVIRAL CFTR GENE TRANSFER EXTENDS THE LIFETIME OF CF MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2012 | McQualter, J., Farrow, N., Parsons, D., & Bertoncello, I. (2012). ENDOGENOUS LUNG EPITHELIAL STEM/PROGENITOR CELL COMPARTMENTS DIFFER IN CYSTIC FIBROSIS AND NORMAL MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2012 | Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). HIGH FRAME RATE IMAGING OF NASAL FLUID DOSING DYNAMICS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. |
| 2011 | Cmielewski, P., & Parsons, D. W. (2011). BIOLUMINESCENCE GENE EXPRESSION WITH A LENTIVIRAL VECTOR IN AIRWAYS OF CYSTIC FIBROSIS MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2011 | Donnelley, M., Siu, K. K., Morgan, K. S., & Parsons, D. W. (2011). DRY DEPOSITION OF POLLUTANT AND MARKER PARTICLES ONTO LIVE MOUSE AIRWAY SURFACES REVEALS HETEROGENEOUS MUCOCILIARY TRANSIT BEHAVIOUR. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. |
| 2009 | Donnelley, M. W., Morgan, K., Fouras, A., Skinner, W., Uesugi, K., Yagi, N., . . . Parsons, D. W. (2009). Individual particulate mucociliary transit analysis using synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 23rd Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Minneapolis, Minn.: Wiley-Liss. DOI |
| 2007 | Liu, C., Wong, E., Tan, C., Anson, D., Smith, G., & Parsons, D. W. (2007). <i>In-vivo</i> mouse and sheep lung gene transfer with a VSV-G pseudotyped lentivirus vector after LPC-pretreatment. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-LISS. |
| Year | Citation |
|---|---|
| - | Smith, R., Carron, A. M., Donnelley, M., Parsons, D., Morgan, K., Reyne, N., & Cmielewski, P. (n.d.). Directional Dark-Field Imaging Data of Magnet Assisted Airway Treatment Delivery. DOI |
| Year | Citation |
|---|---|
| 2024 | McCarron, A., Ling, K. -M., Montgomery, S., Martinovich, K., Cmielewski, P., Rout-Pitt, N., . . . Donnelley, M. (2024). Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway models. DOI |
Funding
NHMRC Research Funding
| 2016 | Project Grant - 1098127 | Identifying the role of airway stem cells in maintaining lentiviral mediated gene expression for cystic fibrosis lung disease | $814,272.20 |
| 2015 | Project - APP1079712 | Revolutionising the diagnosis and monitoring of CF lung disease | $792,777.95 |
| 2013 | Development Grants - APP1055116 | From the synchrotron to the clinic: translation of a novel functional lung imaging technology | $859,797.00 |
Other Research Funding
| 2015 | International - FOURAS15GI0 | CIB | USA CF Foundation | $127,000.00 |
| 2015 | Cure4CF Foundation, Ltd | CIA | Philanthropic | $152,000.00 |
| 2015 | International - PARSON15G0 | CIA | USA CF FOUNDATION | $275,000.00 |
| 2014 | Supplemental support | Team Leader, CIA | Philanthropic - Cure4CF Foundation, Scott family trust | $230,000.00 |
| 2014 | NGO's (non-profit) | CIB | Women's & Children's Hospital Foundation | $69,687.00 |
| 2013 | Supplement Support - Philanthropic | Team Leader, CIA | WCH Foundation / Scott family trust | $250,000.00 |
| 2012 | 366-13110843 - University | CIA | Centre for Stem Cell Research (CSCR) | $64,000.00 |
| 2012 | NGO's (non-profit) | CIB | WCH Foundation | $43,754.00 |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2021 - 2024 | Co-Supervisor | Novel Tools and Models for In-vivo Assessment of Lung Health in Cystic Fibrosis | Doctor of Philosophy | Doctorate | Full Time | Mrs Nikki Reyne |
| 2016 - 2021 | Principal Supervisor | Overcoming Challenges to Development of a Lentiviral-Mediated Airway Gene-Addition Therapy for Cystic Fibrosis | Doctor of Philosophy | Doctorate | Full Time | Miss Alexandra Sarah Ann Mc Carron |
| 2014 - 2014 | Co-Supervisor | Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA | Doctor of Philosophy | Doctorate | Full Time | Dr Chantelle McIntyre |
| 2013 - 2019 | Principal Supervisor | Development of Lentiviral Airway Gene Therapy Aerosol Delivery Techniques for Cystic Fibrosis | Doctor of Philosophy | Doctorate | Full Time | Ms Harshavardini Padmanabhan |
| 2011 - 2015 | Principal Supervisor | Cystic Fibrosis: The role of airway stem cells in sustained gene expression by lentiviral directed gene therapy | Doctor of Philosophy | Doctorate | Full Time | Dr Nigel Farrow |
| 2006 - 2013 | Principal Supervisor | Longevity of Airway Gene Therapy for Cystic Fibrosis: Single and Repeat Lentiviral Dosing | Doctor of Philosophy | Doctorate | Part Time | Dr Patricia Lucia Cmielewski |
| 2006 - 2010 | Co-Supervisor | Cystic Fibrosis Gene Therapy: Methods for the Optimisation of CFTR Gene Delivery | Doctor of Philosophy | Doctorate | Full Time | Mrs Karlea Lee Kremer |
| 2004 - 2010 | Co-Supervisor | Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression | Doctor of Philosophy | Doctorate | Part Time | Ms Alice Stocker |
| 1998 - 2003 | Principal Supervisor | A LENTIVIRAL GENE TRANSFER VECTOR FOR THE TREATMENT OF CYSTIC FIBROSIS AIRWAY DISEASE | Doctor of Philosophy | Doctorate | Full Time | Dr Maria Limberis |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2012 - ongoing | Member | Imaging and Medical, Programme Advisory Committee (PAC) | Australian Synchrotron | - |
| 2010 - ongoing | Founder | Management Committee | National Non-Human Primate Breeding and Research Facility | - |
| 2009 - ongoing | Member | Animal studies establishment committee | Australian Synchrotron | - |
| 2009 - ongoing | Member | Australian and New Zealand Society of Respiratory Science | - | - |
| Date | Role | Membership | Country |
|---|---|---|---|
| 2003 - ongoing | - | American Society of Gene and Cell Therapy | - |
| 2003 - ongoing | - | Australian Gene Therapy Society | - |
| 1991 - ongoing | - | Australia and New Zealand Society for Respiratory Science | - |
| 1991 - ongoing | - | Thoracic Society of Australia and New Zealand | - |
| 1990 - ongoing | - | South Australian Medical Scientists Association | - |
| Date | Institution | Department | Organisation Type | Country |
|---|---|---|---|---|
| 2009 - ongoing | Australian Synchrotron | - | - | - |
| 2008 - 2013 | American Society of Gene and Cell Therapy | - | - | - |
