David Parsons
Adelaide Medical School
Faculty of Health and Medical Sciences
Associate Professor David Parsons, Chief Medical Scientist. TITLEHOLDER
Associate Professor David Parsons is the leader of the Cystic Fibrosis Stream at the Children's Research Centre and was Chief Medical Scientist in the Department of Respiratory And Sleep Medicine at the Women's and Children's Hospital before he retired from that position in 2005. He was also Head of the Adelaide Cystic Fibrosis Gene Therapy Group at the Robinson Institute, and an Affiliate Senior Lecturer in the Discipline of Paediatrics at the University of Adelaide.
Associate Professor David Parsons devoted the past 35 years to finding a cure for Cystic Fibrosis (CF) airway disease and has twice-won Service Excellence Awards administered by the Women's and Children's Health Network for his innovations in this and related fields. He is a Fellow of the ANZSRS. He and his research team have pioneered a ground-breaking gene therapy technique that has been successful in reversing the basic cellular defect that causes CF in mouse models, and that holds promise as a long-lasting treatment for CF lung disease.
He was also responsible for initiating and championing leading-edge research into the surface behaviour of airways in health and disease using non-invasive synchrotron X-ray imaging techniques. By measuring the ASL and microscopic particles previously considered too small to view, in living animal-model airways, David pioneered new and more effective ways of measuring the success of respiratory treatments like gene therapy in CF patients. He worked closely with Andreas Fouras, now CEO of the Australian X-ray imaging company 4DMedical Pty Ltd, to bring the use of X-ray velocimetry to the assessment of lung health in animal models, a technique now in paediatric clinical trials. He was one of the 5 researchers awarded the 2023 Eureka Prize for Excellence in Interdisciplinary Research.
David's development of CF airway gene transfer methods were supported initially by the USA CF Foundation, and evolved to attract regular funding from the National Health and Medical Research Council in Australia, and from the Medical Research Future Fund (MRFF).
Research
Since the mid 1990's I have been developing airway gene transfer methods to achieve a safe and effective treatment or cure for clinical use for the lung disease of cystic fibrosis. I have led the Adelaide CF Airway Gene Therapy group since establishing it in 1997. My establishment of reliable and effective in-vivo airway gene vector dosing and gene expression measurement has been coupled with developing effective, rapid and non-invasive measurement of airway health in CF airways using synchrotron and other X-rays along with other in-vivo imaging such as biophotonic techniques based on luciferase gene transfer.
My interest and expertise space three themes.
(1) Development of novel analysis methods with potentially wide applicability. Starting with novel measurements of single-neuron activity in the Aplysia animal model in-vivo (Science 221, 1203-, 1983), now I am championing development of synchrotron X-ray imaging to investigate animal airway health and physiology in-vivo.
(2) Enablement of practical advances in medical therapy with potentially fundamental value, demonstrated by the >16 years efforts in development of airway gene transfer for treatment or cure of CF airway disease. This theme has advanced into the translational preclinical arena with initial trials of airway gene transfer in a non-human primate lung model (the marmoset).
(3) The last theme is the fostering of new and often cross-discipline collaborations, local and worldwide. My expansion into synchrotron X-ray physics to develop new airway health outcome measurements, based at the Japanese SPring-8 synchrotron, is an obvious example.
I continually supervise Honors and PhD students to foster new research careers, and I played a key role in establishing a community-based research Foundation (www.cure4cf.org) that has supplemented and supported the continuity, resilience, and bridging-salary needs of our CF airway gene therapy research program.
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Appointments
Date Position Institution name 2008 - 2025 Chief Medical Scientist Women's and Children's Hospital, Adelaide 2001 - ongoing Affiliate Senior Lecturer University of Adelaide, Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Award Research Medal Australian and New Zealand Society of Respiratory Scientists - - 2012 Fellowship Fellow (designation: FANZSRS) Australia and New Zealand Society of Respiratory Scientists - - -
Education
Date Institution name Country Title 1977 - 1981 University of Melbourne Australia PhD 1976 - 1976 University of Melbourne Australia BSc(Hons) 1971 - 1973 University of Melbourne, Melbourne Australia BSc (Information & Computer Science) -
Certifications
Date Title Institution name Country 2016 FANZSRS Australian and New Zealand Society of Respiratory Scientists Australia -
Research Interests
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Journals
Year Citation 2025 Rout-Pitt, N., Boog, B., McCarron, A., Reyne, N., Parsons, D., & Donnelley, M. (2025). Insights into epithelial-mesenchymal transition from cystic fibrosis rat models.. J Cyst Fibros, 24(1), 149-156.
Scopus12025 Reyne, N., Smith, R., Cmielewski, P., Eikelis, N., Nilsen, K., Louise, J., . . . Donnelley, M. (2025). Functional Lung Imaging Identifies Peripheral Ventilation Changes in ꞵ-ENaC Mice. Respirology (Carlton, Vic.), 30(4), 335-345.
2025 Desrosiers-Battu, L. R., Lee, J. H., Tarasiewicz, I., Gilbert, A. R., Galvan, E. M., Singh, A. K., . . . Shah, S. (2025). Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome. Cancer Genetics, 292-293, 106-110.
2025 Feizi, S., Cooksley, C. M., Reyne, N., Boog, B., Finnie, J., Shaghayegh, G., . . . Vreugde, S. (2025). An immunocompetent rat model of Mycobacterium abscessus multinodular granulomatous lung infection. Tuberculosis, 152, 8 pages.
2025 Bruorton, M., Greenslade, S., Perveen, S., Donnelley, M., O'Connor, A., Phillips, J., . . . Tai, A. (2025). Pediatric functional lung imaging and pulmonary function testing: A scoping review protocol. JBI Evidence Synthesis.
2024 Reyne, N., Smith, R., Cmielewski, P., Eikelis, N., Lawrence, M., Louise, J., . . . Donnelley, M. (2024). Assessment of respiratory mechanics and X-ray velocimetry functional imaging in two cystic fibrosis rat models. Scientific Reports, 14(1), 10 pages.
Scopus1 Europe PMC22024 McCarron, A., Ling, K. -M., Montgomery, S. T., Martinovich, K. M., Cmielewski, P., Rout-Pitt, N., . . . Donnelley, M. (2024). Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway models. Gene Therapy, 31(11-12), 553-559.
2024 Li, D., Zhu, Y., Donnelley, M., Parsons, D., Habgood, M. D., & Schneider-Futschik, E. K. (2024). Fetal drug exposure after maternally administered CFTR modulators Elexacaftor/Tezacaftor/Ivacaftor in a rat model. Biomedicine and Pharmacotherapy, 171, 116155-1-116155-9.
Scopus10 Europe PMC32024 Bruorton, M., Donnelley, M., Goddard, T., O’Connor, A., Parsons, D., Phillips, J., . . . Tai, A. (2024). Pilot study of paediatric regional lung function assessment via X-ray velocimetry (XV) imaging in children with normal lungs and in children with cystic fibrosis. BMJ Open, 14(2), 7 pages.
Scopus1 Europe PMC22024 Reyne, N., Cmielewski, P., McCarron, A., Smith, R., Eikelis, N., Pirakalathanan, P., . . . Donnelley, M. (2024). Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats. Frontiers in Pharmacology, 15, 1-7.
Scopus4 Europe PMC62024 McCabe, M. G., Geoerger, B., Chesler, L., Hargrave, D., Parsons, D. W., van Tilburg, C. M., . . . George, S. L. (2024). Precision Medicine for Childhood Cancer: Current Limitations and Future Perspectives. JCO Precision Oncology, 8(8), 6 pages.
Scopus4 Europe PMC42024 Smith, R., Morgan, K. S., McCarron, A., Cmielewski, P., Reyne, N., Parsons, D., & Donnelley, M. (2024). Ultra-fastin-vivodirectional dark-field x-ray imaging for visualising magnetic control of particles for airway gene delivery. Phys Med Biol, 69(10), 105025-1-105025-11.
Scopus1 Europe PMC12024 Li, D., Donnelley, M., Parsons, D., Habgood, M. D., & Schneider-Futschik, E. K. (2024). Extent of foetal exposure to maternal elexacaftor/tezacaftor/ivacaftor during pregnancy. British Journal of Pharmacology, 181(15), 2413-2428.
Scopus5 Europe PMC12024 Reyne, N., Cmielewski, P., McCarron, A., Smith, R., Schneider-Futschik, E., Eikelis, N., . . . Donnelley, M. (2024). Corrigendum: Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats(Front. Pharmacol., (2024), 15, (1362325), 10.3389/fphar.2024.1362325). Frontiers in Pharmacology, 15, 1428213.
2023 Donnelley, M., Cmielewski, P., Knight, E., Carpentieri, C., McCarron, A., Rout-Pitt, N., . . . Farrow, N. (2023). Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing. Gene Therapy, 30(9), 1-8.
Scopus4 Europe PMC12023 Donnelley, M., Lagerquist, L., Cmielewski, P., Reyne, N., Morgan, K., & Parsons, D. (2023). Noncontact Respiratory Motion Detection in Anesthetized Rodents. Journal of the American Association for Laboratory Animal Science, 62(6), 559-568.
Scopus2 Europe PMC12023 McCarron, A., Cmielewski, P., Drysdale, V., Parsons, D., & Donnelley, M. (2023). Effective viral-mediated lung gene therapy: is airway surface preparation necessary?. Gene Therapy, 30(6), 469-477.
Scopus19 WoS8 Europe PMC212023 Donnelley, M., Parsons, D., & Prichard, I. (2023). Perceptions of airway gene therapy for cystic fibrosis. Expert Opinion on Biological Therapy, 23(1), 103-113.
Scopus4 WoS2 Europe PMC22023 Reyne, N., McCarron, A., Cmielewski, P., Parsons, D., & Donnelley, M. (2023). To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis. FRONTIERS IN PHYSIOLOGY, 14, 13 pages.
Scopus16 WoS2 Europe PMC122023 Shrestha, N., Rout-Pitt, N., McCarron, A., Jackson, C. A., Bulmer, A. C., McAinch, A. J., . . . Hryciw, D. H. (2023). Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis. International Journal of Molecular Sciences, 24(8), 7194-1-7194-10.
Scopus3 Europe PMC22022 Donnelley, M., Cmielewski, P., Morgan, K., Delhove, J., Reyne, N., McCarron, A., . . . Parsons, D. (2022). Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging. Scientific Reports, 12(1), 9000-1-9000-14.
Scopus2 Europe PMC12022 Jung, H. W., Lee, I., Lee, S. H., Morgan, K., Parsons, D., & Donnelley, M. (2022). Mucociliary Transit Assessment Using Automatic Tracking in Phase Contrast X-Ray Images of Live Mouse Nasal Airways. Journal of Medical and Biological Engineering, 42(5), 545-554.
Scopus1 WoS12022 Drysdale, V., Cmielewski, P., Donnelley, M., Reyne, N., Parsons, D., & McCarron, A. (2022). Comparison of physical perturbation devices for enhancing lentiviral vector-mediated gene transfer to the airway epithelium.. Human gene therapy, 33(19-20), 1062-1072.
2022 Lau, K. K., Troupis, J. M., & Parsons, D. (2022). Transformative radiology: Chest imaging is being re-defined. Respirology, 27(10), 815-817.
Scopus22022 Shrestha, N., McCarron, A., Rout-Pitt, N., Donnelley, M., Parsons, D. W., & Hryciw, D. H. (2022). Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex. Nutrients, 14(21), 4666.
Scopus8 WoS2 Europe PMC92022 Chandramohan, R., Reuther, J., Gandhi, I., Voicu, H., Alvarez, K. R., Plon, S. E., . . . Roy, A. (2022). A Validation Framework for Somatic Copy Number Detection in Targeted Sequencing Panels. Journal of Molecular Diagnostics, 24(7), 760-774.
Scopus7 Europe PMC62022 Scollon, S., Eldomery, M. K., Reuther, J., Lin, F. Y., Potter, S. L., Desrosiers, L., . . . Plon, S. E. (2022). Clinical and molecular features of pediatric cancer patients with Lynch syndrome. Pediatric Blood and Cancer, 69(11), 6 pages.
Scopus14 Europe PMC102022 Kogiso, M., Qi, L., Du, Y., Braun, F. K., Zhang, H., Huang, L. F., . . . Li, X. N. (2022). Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma. Translational Oncology, 18, 11 pages.
Scopus7 Europe PMC62022 Garcia, A., Desrosiers, L., Scollon, S., Gruner, S., Reuther, J., Gandhi, I., . . . Roy, A. (2022). Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome. Cancer Genetics, 262-263, 53-56.
Scopus2 Europe PMC22022 Eckstein, O. S., Allen, C. E., Williams, P. M., Roy-Chowdhuri, S., Patton, D. R., Coffey, B., . . . Parsons, D. W. (2022). Phase II Study of Selumetinib in Children and Young Adults with Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm e of the NCI-COG Pediatric MATCH Trial. Journal of Clinical Oncology, 40(20), 2235-2245.
Scopus39 Europe PMC352022 Parsons, D. W., Janeway, K. A., Patton, D. R., Winter, C. L., Coffey, B., Williams, P. M., . . . Seibel, N. L. (2022). Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients with Refractory Cancers in the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial. Journal of Clinical Oncology, 40(20), 2224-2234.
Scopus76 Europe PMC682021 Potter, S. L., Reuther, J., Chandramohan, R., Gandhi, I., Hollingsworth, F., Sayeed, H., . . . Parsons, D. W. (2021). Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma. Pediatric Blood and Cancer, 68(1), 9 pages.
Scopus20 Europe PMC92021 Mangum, R., Reuther, J., Bertrand, K. C., Chandramohan, R., Kukreja, M. K., Paulino, A. C., . . . Lin, F. Y. (2021). Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling. JCO Precision Oncology, 5(5), 1221-1227.
Scopus8 Europe PMC72021 Ting, M. A., Reuther, J., Chandramohan, R., Voicu, H., Gandhi, I., Liu, M., . . . Parsons, D. W. (2021). Genomic analysis and preclinical xenograft model development identify potential therapeutic targets for MYOD1-mutant soft-tissue sarcoma of childhood. Journal of Pathology, 255(1), 52-61.
Scopus4 Europe PMC32021 Hsu, R. L., Gutierrez, A. M., Schellhammer, S. K., Robinson, J. O., Scollon, S., Street, R. L., . . . McGuire, A. L. (2021). Pediatric Oncologists' Experiences Returning and Incorporating Genomic Sequencing Results into Cancer Care. JOURNAL OF PERSONALIZED MEDICINE, 11(6), 12 pages.
Europe PMC32021 Chandramohan, R., Kakkar, N., Roy, A., & Parsons, D. W. (2021). ReconCNV: Interactive visualization of copy number data from high-throughput sequencing. Bioinformatics, 37(8), 1164-1167.
Scopus6 Europe PMC52021 Rout-Pitt, N., Donnelley, M., & Parsons, D. (2021). In vitro optimization of miniature bronchoscope lentiviral vector delivery for the small animal lung. Experimental Lung Research, 47(9), 417-425.
2021 Hryciw, D. H., Jackson, C. A., Shrestha, N., Parsons, D., Donnelley, M., & McAinch, A. J. (2021). Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis. Cellular and Molecular Life Sciences, 78(24), 7991-7999.
Scopus3 WoS1 Europe PMC32021 Carpentieri, C. L., Farrow, N. R., Cmielewski, P., Rout-Pitt, N., Mc Carron, A., Knight, E., . . . Donnelley, M. (2021). The effects of conditioning and lentiviral vector pseudotype on short- and long-term airway reporter gene expression in mice.. Human gene therapy, 32(15-16), 817-827.
Scopus4 WoS4 Europe PMC32021 Mc Carron, A., Farrow, N., Cmielewski, P., Knight, E., Donnelley, M., & Parsons, D. (2021). Breaching the delivery barrier: Chemical and physical airway epithelium disruption strategies for enhancing lentiviral-mediated gene therapy. Frontiers in Pharmacology, 12, 669635-1-669635-11.
Scopus6 WoS5 Europe PMC52021 Reyne, N., Cmielewski, P., Mc Carron, A., Delhove, J., Parsons, D., & Donnelley, M. (2021). Single-dose lentiviral mediated gene therapy recovers CFTR function in cystic fibrosis knockout rats. Frontiers in Pharmacology, 12, 682299-1-682299-8.
Scopus11 WoS6 Europe PMC102021 Cmielewski, P., Delhove, J., Donnelley, M., & Parsons, D. (2021). Assessment of Lentiviral Vector Mediated CFTR Correction in Mice Using an Improved Rapid in vivo Nasal Potential Difference Measurement Protocol. Frontiers in Pharmacology : Respiratory Pharmacology, 12, 714452-1-714452-11.
Scopus4 WoS1 Europe PMC42021 Farrow, N. R., Cmielewski, P., Delhove, J., Rout-Pitt, N., Vaughan, L., Kuchel, T., . . . Parsons, D. (2021). Towards human translation of lentiviral airway gene delivery for cystic fibrosis: A one-month CFTR and reporter gene study in marmosets. Human Gene Therapy, 32(15-16), 806-816.
Scopus10 WoS8 Europe PMC32021 Mc Carron, A., Parsons, D., & Donnelley, M. (2021). Animal and cell culture models for cystic fibrosis: which model is right for your application?. American Journal of Pathology, 191(2), 228-242.
Scopus57 WoS27 Europe PMC492020 Morgan, K. S., Parsons, D., Cmielewski, P., McCarron, A., Gradl, R., Farrow, N., . . . Donnelley, M. (2020). Methods for dynamic synchrotron X-ray respiratory imaging in live animals. Journal of synchrotron radiation, 27(Pt 1), 164-175.
Scopus25 WoS16 Europe PMC142020 Kicic, A., de Jong, E., Ling, K. M., Nichol, K., Anderson, D., Wark, P. A. B., . . . Veerati, P. C. (2020). Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium. Journal of Allergy and Clinical Immunology, 154(6), 1562-1573.
Scopus43 WoS26 Europe PMC342020 Tran, H. B., Macowan, M. G., Abdo, A., Donnelley, M., Parsons, D., & Hodge, S. (2020). Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model. Journal of Inflammation (United Kingdom), 17(1), 16.
Scopus6 WoS6 Europe PMC62020 Werdiger, F., Donnelley, M., Dubsky, S., Murrie, R. P., Carnibella, R. P., Samarage, C. R., . . . Morgan, K. S. (2020). Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry. Scientific Reports, 10(1), 10859-1-10859-12.
Scopus8 WoS2 Europe PMC82020 Parsons, D., & Donnelley, M. (2020). Will airway gene therapy for cystic fibrosis improve lung function? New imaging technologies can help us find out. Human Gene Therapy, 31(17-18), 973-984.
Scopus8 WoS3 Europe PMC62020 Murrie, R. P., Werdiger, F., Donnelley, M., Lin, Y. W., Carnibella, R. P., Samarage, C. R., . . . Fouras, A. (2020). Real-time in vivo imaging of regional lung function in a mouse model of cystic fibrosis on a laboratory X-ray source. Scientific Reports, 10(1), 447.
Scopus28 WoS15 Europe PMC192020 Gardner, M., Parsons, D., Morgan, K. S., McCarron, A., Cmielewski, P., Gradl, R., & Donnelley, M. (2020). Towards automated <i>in vivo</i> tracheal mucociliary transport measurement: detecting and tracking particle movement in synchrotron phase-contrast X-ray images. Physics in Medicine and Biology, 65(14), 145012-1-145012-17.
Scopus6 Europe PMC22020 McCarron, A., Cmielewski, P., Reyne, N., McIntyre, C., Finnie, J., Craig, F., . . . Donnelley, M. (2020). Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology, 190(5), 977-993.
Scopus34 WoS20 Europe PMC292020 Yost, C. M., Gaikwad, A. S., Parsons, D. W., Rabin, K. R., Gant, V. U., Fisher, K. E., . . . Schafer, E. S. (2020). Aberrant leukemia-associated immunophenotype as potential harbinger of lineage switch in KMT2A-rearranged leukemia: a case series. Leukemia and Lymphoma, 61(14), 3515-3518.
Scopus4 Europe PMC12020 Vo, K. T., Parsons, D. W., & Seibel, N. L. (2020). Precision Medicine in Pediatric Oncology. Surgical Oncology Clinics of North America, 29(1), 63-72.
Scopus22 Europe PMC172020 Li, J., Zhao, S., Lee, M., Yin, Y., Li, J., Zhou, Y., . . . Sun, D. (2020). Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. SCIENCE ADVANCES, 6(42), 14 pages.
Europe PMC512019 Miklja, Z., Pasternak, A., Stallard, S., Nicolaides, T., Kline-Nunnally, C., Cole, B., . . . Koschmann, C. (2019). Molecular profiling and targeted therapy in pediatric gliomas: Review and consensus recommendations. Neuro-Oncology, 21(8), 968-980.
Scopus54 Europe PMC462019 Kastury, F., Smith, E., Lombi, E., Donnelley, M. W., Cmielewski, P. L., Parsons, D. W., . . . Juhasz, A. L. (2019). Dynamics of lead bioavailability and speciation in indoor dust and x-ray spectroscopic investigation of the link between ingestion and inhalation pathways. Environmental Science and Technology, 53(19), 11486-11495.
Scopus33 WoS25 Europe PMC192019 Malek, J., Pereira, S., Robinson, J. O., Gutierrez, A. M., Slashinski, M. J., Parsons, D. W., . . . McGuire, A. L. (2019). Responsibility, culpability, and parental views on genomic testing for seriously ill children. Genetics in Medicine, 21(12), 2791-2797.
Scopus27 Europe PMC162019 Hassan, M., Butler, E., Wilson, R., Roy, A., Zheng, Y., Liem, P., . . . Laetsch, T. W. (2019). Novel <i>PDGFRB</i> rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib. COLD SPRING HARBOR MOLECULAR CASE STUDIES, 5(5), 15 pages.
Europe PMC112019 Lindsay, H., Scollon, S., Reuther, J., Voicu, H., Rednam, S. P., Lin, F. Y., . . . Roy, A. (2019). Germline <i>POLE</i> mutation in a child with hypermutated medulloblastoma and features of constitutional mismatch repair deficiency. COLD SPRING HARBOR MOLECULAR CASE STUDIES, 5(5), 12 pages.
Europe PMC182019 Haines, K., Sarabia, S. F., Alvarez, K. R., Tomlinson, G., Vasudevan, S. A., Heczey, A. A., . . . López-Terrada, D. (2019). Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation. Pediatric Blood and Cancer, 66(7), 10 pages.
Scopus37 Europe PMC232019 Gutierrez, A. M., Statham, E. E., Robinson, J. O., Slashinski, M. J., Scollon, S., Bergstrom, K. L., . . . McGuire, A. L. (2019). Agents of empathy: How medical interpreters bridge sociocultural gaps in genomic sequencing disclosures with Spanish-speaking families. Patient Education and Counseling, 102(5), 895-901.
Scopus22 Europe PMC102019 Scollon, S., Majumder, M. A., Bergstrom, K., Wang, T., McGuire, A. L., Robinson, J. O., . . . Street, R. L. (2019). Exome sequencing disclosures in pediatric cancer care: Patterns of communication among oncologists, genetic counselors, and parents. Patient Education and Counseling, 102(4), 680-686.
Scopus16 Europe PMC142019 Kastury, F., Smith, E., Doelsch, E., Lombi, E., Donnelley, M., Cmielewski, P. L., . . . Juhasz, A. L. (2019). In Vitro, in Vivo, and Spectroscopic Assessment of Lead Exposure Reduction via Ingestion and Inhalation Pathways Using Phosphate and Iron Amendments. Environmental Science and Technology, 53(17), 10329-10341.
Scopus39 WoS34 Europe PMC202019 Jung, H. W., Lee, S. H., Donnelley, M., Parsons, D., Stamatescu, V., & Lee, I. (2019). Multiple particle tracking in time-lapse synchrotron X-ray images using discriminative appearance and neighbouring topology learning. Pattern Recognition, 93, 485-497.
Scopus6 WoS32019 Gardner, M. T., McCarron, A., Morgan, K., Parsons, D., & Donnelley, M. (2019). Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study. Scientific Reports, 9(1), 10983-1-10983-10.
Scopus6 WoS2 Europe PMC12019 Donnelley, M., Morgan, K. S., Gradl, R., Klein, M., Hausermann, D., Hall, C., . . . Parsons, D. W. (2019). Live-pig-airway surface imaging and whole-pig CT at the Australian Synchrotron Imaging and Medical Beamline. Journal of Synchrotron Radiation, 26(1), 175-183.
Scopus14 WoS11 Europe PMC42019 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2019). Transient lentiviral vector production using a packed-bed bioreactor system. Human Gene Therapy Methods, 30(3), 93-101.
Scopus23 WoS17 Europe PMC182018 Donnelley, M., & Parsons, D. W. (2018). Gene therapy for cystic fibrosis lung disease: overcoming the barriers to translation to the clinic. Frontiers in Pharmacology, 9(NOV), 1-8.
Scopus37 WoS29 Europe PMC222018 Wang, Z., Cai, J., Guo, W., Donnelley, M., Parsons, D., & Lee, I. (2018). Backprojection Wiener deconvolution for computed tomographic reconstruction. PLoS ONE, 13(12), e0207907-1-e0207907-22.
Scopus5 WoS2 Europe PMC22018 McCarron, A., Donnelley, M., & Parsons, D. (2018). Airway disease phenotypes in animal models of cystic fibrosis. Respiratory Research, 19(1), 54-1-54-12.
Scopus66 WoS48 Europe PMC562018 Rout-Pitt, N., Farrow, N., Parsons, D., & Donnelley, M. (2018). Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology. Respiratory Research, 19(1), 136-1-136-10.
Scopus220 WoS151 Europe PMC1462018 McIntyre, C., Donnelley, M., Rout-Pitt, N., & Parsons, D. (2018). Lobe-specific gene vector delivery to rat lungs using a miniature bronchoscope. Human Gene Therapy Methods, 29(5), 228-235.
Scopus17 WoS14 Europe PMC102018 Rout-Pitt, N. B., McCarron, A., McIntyre, C., Parsons, D., & Donnelley, M. (2018). Large-scale production of lentiviral vectors using multilayer cell factories. Journal of Biological Methods, 5(2), e90-1-e90-9.
Europe PMC152018 Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Moodley, Y., Bertoncello, I., & Parsons, D. (2018). Epithelial disruption: a new paradigm enabling human airway stem cell transplantation. Stem Cell Research and Therapy, 9(1), 153-1-153-8.
Scopus22 WoS16 Europe PMC202018 Farrow, N., Donnelley, M., Cmielewski, P., Roscioli, E., Rout-Pitt, N., McIntyre, C., . . . Parsons, D. (2018). Role of basal cells in producing persistent lentivirus-mediated airway gene expression. Human Gene Therapy, 29(6), 653-662.
Scopus16 WoS16 Europe PMC112018 McClain, K. L., Picarsic, J., Chakraborty, R., Zinn, D., Lin, H., Abhyankar, H., . . . Allen, C. E. (2018). CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions. Cancer, 124(12), 2607-2620.
Scopus92 Europe PMC552018 Laetsch, T. W., Roy, A., Xu, L., Black, J. O., Coffin, C. M., Chi, Y. -Y., . . . Skapek, S. X. (2018). Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children's Oncology Group. CLINICAL CANCER RESEARCH, 24(16), 3888-3897.
Europe PMC92017 Kogiso, M., Qi, L., Lindsay, H., Huang, Y., Zhao, X., Liu, Z., . . . Li, X. -N. (2017). Xenotransplantation of pediatric low grade gliomas confirms the enrichment of <i>BRAF</i> V600E mutation and preservation of <i>CDKN2A</i> deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma. ONCOTARGET, 8(50), 87455-87471.
Europe PMC222017 Bavle, A., & Parsons, D. W. (2017). From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy. Cancer Cell, 31(6), 727-729.
Scopus11 Europe PMC52017 Heikamp, E. B., Parsons, D. W., & Plon, S. E. (2017). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Adrenocortical Neoplasms with Hemihypertrophy, Brain Tumors, and Other Disorders. Journal of Pediatrics, 180, 115.
Scopus12017 Peckham-Gregory, E. C., Chakraborty, R., Scheurer, M. E., Belmont, J. W., Abhyankar, H., Sengal, A. G., . . . Allen, C. E. (2017). A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility. Blood, 130(20), 2229-2232.
Scopus23 Europe PMC152017 Allen, C. E., Laetsch, T. W., Mody, R., Irwin, M. S., Lim, M. S., Adamson, P. C., . . . Takebe, N. (2017). Target and Agent Prioritization for the Children's Oncology Group - National Cancer Institute Pediatric MATCH Trial. Journal of the National Cancer Institute, 109(5), 13 pages.
Scopus97 Europe PMC662017 Potter, S. L., Venkatramani, R., Wenderfer, S., Graham, B. H., Vasudevan, S. A., Sher, A., . . . Parsons, D. W. (2017). Renal cell carcinoma harboring somatic TSC2 mutations in a child with methylmalonic acidemia. Pediatric Blood and Cancer, 64(5), 4 pages.
Scopus11 Europe PMC62017 Mody, R. J., Prensner, J. R., Everett, J., Parsons, D. W., & Chinnaiyan, A. M. (2017). Precision medicine in pediatric oncology: Lessons learned and next steps. Pediatric Blood and Cancer, 64(3), 14 pages.
Scopus77 Europe PMC472017 Malek, J., Slashinski, M. J., Robinson, J. O., Gutierrez, A. M., Parsons, D. W., Plon, S. E., . . . McGuire, A. L. (2017). Parental perspectives on whole-exome sequencing in pediatric cancer: A typology of perceived utility. JCO Precision Oncology, 2017(1), 1-10.
Scopus49 Europe PMC342017 Sumazin, P., Chen, Y., Treviño, L. R., Sarabia, S. F., Hampton, O. A., Patel, K., . . . López-Terrada, D. (2017). Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology, 65(1), 104-121.
Scopus176 Europe PMC1282017 Cmielewski, P., Farrow, N., Devereux, S., Parsons, D., & Donnelley, M. (2017). Gene therapy for Cystic Fibrosis: improved delivery techniques and conditioning with lysophosphatidylcholine enhance lentiviral gene transfer in mouse lung airways. Experimental Lung Research, 43(9-10), 426-433.
Scopus30 WoS28 Europe PMC182017 Jung, H., Sang-Heon, L., Donnelley, M., Parsons, D., & Lee, I. (2017). Automated detection of circular marker particles in synchrotron phase contrast X-ray images of live mouse nasal airways for mucociliary transit assessment. Expert Systems with Applications, 73, 57-68.
Scopus10 WoS82017 Donnelley, M., Morgan, K., Awadalla, M., Farrow, N., Hall, C., & Parsons, D. (2017). High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging. Respiratory research, 18(1), 95-1-95-11.
Scopus19 WoS18 Europe PMC132016 Stahr, C., Samarage, C., Donnelley, M., Farrow, N., Morgan, K., Zosky, G., . . . Fouras, A. (2016). Quantification of heterogeneity in lung disease with image-based pulmonary function testing. Scientific Reports, 6(1), 29438-1-29438-10.
Scopus54 WoS42 Europe PMC422016 McCarron, A., Donnelley, M., McIntyre, C., & Parsons, D. (2016). Challenges of up-scaling lentivirus production and processing. Journal of Biotechnology, 240, 23-30.
Scopus93 WoS63 Europe PMC632016 Morgan, K., Petersen, T., Donnelley, M., Farrow, N., Parsons, D., & Paganin, D. (2016). Capturing and visualizing transient X-ray wavefront topological features by single-grid phase imaging. Optics Express, 24(21), 24435-24450.
Scopus8 WoS6 Europe PMC32016 Donnelley, M., Awadalla, M., Morgan, K., Farrow, N., Hall, C., Acres, R., & Parsons, D. (2016). ASSESSING PARTICLE MUCOCILIARY TRANSIT IN EXCISED SHEEP TRACHEA USING THE AUSTRALIAN SYNCHROTRON IMAGING AND MEDICAL BEAMLINE. RESPIROLOGY, 21, 167. 2016 Hingorani, P., Janeway, K., Crompton, B. D., Kadoch, C., Mackall, C. L., Khan, J., . . . Reed, D. R. (2016). Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop. Cancer Genetics, 209(5), 182-194.
Scopus39 Europe PMC302016 Bissig-Choisat, B., Kettlun-Leyton, C., Legras, X. D., Zorman, B., Barzi, M., Chen, L. L., . . . Bissig, K. D. (2016). Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. Journal of Hepatology, 65(2), 325-333.
Scopus56 Europe PMC432016 Raymond, V. M., Gray, S. W., Roychowdhury, S., Joffe, S., Chinnaiyan, A. M., Parsons, D. W., & Plon, S. E. (2016). Germline findings in tumor-only sequencing: Points to consider for clinicians and laboratories. Journal of the National Cancer Institute, 108(4), 5 pages.
Scopus83 Europe PMC632016 Chakraborty, R., Burke, T. M., Hampton, O. A., Zinn, D. J., Lim, K. P. H., Abhyankar, H., . . . Allen, C. E. (2016). Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis. Blood, 128(21), 2533-2537.
Scopus135 Europe PMC862016 Lin, F. Y., Bergstrom, K., Person, R., Bavle, A., Ballester, L. Y., Scollon, S., . . . Parsons, D. W. (2016). Integrated tumor and germline whole-exome sequencing identifies mutations in MAPK and PI3K pathway genes in an adolescent with rosette-forming glioneuronal tumor of the fourth ventricle. COLD SPRING HARBOR MOLECULAR CASE STUDIES, 2(5), 11 pages.
Europe PMC142016 Bavle, A. A., Lin, F. Y., & Parsons, D. W. (2016). Applications of genomic sequencing in pediatric CNS tumors. ONCOLOGY (United States), 30(5), 411-423.
Scopus2 Europe PMC42016 Parsons, D. W., Roy, A., Yang, Y., Wang, T., Scollon, S., Bergstrom, K., . . . Plon, S. E. (2016). Diagnostic yield of clinical tumor and germline whole-exome sequencing for children with solid tumors. JAMA Oncology, 2(5), 616-624.
Scopus393 Europe PMC2992016 Mccullough, L. B., Slashinski, M. J., Mcguire, A. L., Street, R. L., Eng, C. M., Gibbs, R. A., . . . Plon, S. E. (2016). Is Whole-Exome Sequencing an Ethically Disruptive Technology? Perspectives of Pediatric Oncologists and Parents of Pediatric Patients With Solid Tumors. Pediatric Blood and Cancer, 63(3), 511-515.
Scopus41 Europe PMC272016 Green, R. C., Goddard, K. A. B., Jarvik, G. P., Amendola, L. M., Appelbaum, P. S., Berg, J. S., . . . Filipski, K. (2016). Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. American Journal of Human Genetics, 98(6), 1051-1066.
Scopus120 WoS101 Europe PMC1072015 Berg, S. L., & Parsons, D. W. (2015). The pharmacogenomics of vincristine-induced neuropathy: On pins and needles. JAMA Oncology, 1(7), 975-976.
Scopus7 Europe PMC42015 Scollon, S., Bergstrom, K., Mccullough, L. B., Mcguire, A. L., Gutierrez, S., Kerstein, R., . . . Plon, S. E. (2015). Pediatric Cancer Genetics Research and an Evolving Preventive Ethics Approach for Return of Results after Death of the Subject. Journal of Law, Medicine and Ethics, 43(3), 529-537.
Scopus4 Europe PMC42015 Allen, C. E., & Parsons, D. W. (2015). Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders. Hematology (United States), 2015(1), 559-564.
Scopus52 Europe PMC272015 Roy, A., Kumar, V., Zorman, B., Fang, E., Haines, K. M., Doddapaneni, H. V., . . . Parsons, D. W. (2015). Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nature Communications, 6(1), 7 pages.
Scopus131 Europe PMC842015 Peters, T. L., Kumar, V., Polikepahad, S., Lin, F. Y., Sarabia, S. F., Liang, Y., . . . Roy, A. (2015). BCOR-CCNB3 fusions are frequent in undifferentiated sarcomas of male children. Modern Pathology, 28(4), 575-586.
Scopus118 Europe PMC742015 Murrie, R., Morgan, K., Maksimenko, A., Fouras, A., Paganin, D., Hall, C., . . . Donnelley, M. (2015). Live small-animal X-ray lung velocimetry and lung micro-tomography at the Australian Synchrotron Imaging and Medical Beamline. Journal of Synchrotron Radiation, 22(4), 1049-1055.
Scopus24 WoS21 Europe PMC162014 Cmielewski, P., Farrow, N., Donnelley, M., McIntyre, C., Penny-Dimri, J., Kuchel, T., & Parsons, D. (2014). Transduction of ferret airway epithelia using a pre-treatment and lentiviral gene vector. BMC Pulmonary Medicine, 14(1), 183-1-183-7.
Scopus14 WoS13 Europe PMC92014 Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N. R., Stahr, C. S., Boucher, R. C., . . . Parsons, D. W. (2014). Erratum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo (Scientific Reports 4:3689 DOI: 10.1038/srep03689). Scientific Reports, 4(1), 1 page.
2014 Morgan, K. S., Donnelley, M., Farrow, N., Fouras, A., Yagi, N., Suzuki, Y., . . . Parsons, D. W. (2014). In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 190(4), 469-471.
Scopus27 WoS21 Europe PMC212014 Cmielewski, P., Donnelley, M., & Parsons, D. (2014). Long-term therapeutic and reporter gene expression in lentiviral vector treated cystic fibrosis mice. Journal of Gene Medicine, 16(9-10), 291-299.
Scopus38 WoS34 Europe PMC292014 Donnelley, M., Morgan, K., Siu, K., Fouras, A., Farrow, N., Carnibella, R., & Parsons, D. (2014). Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron X-ray imaging in live mice. Journal of Synchrotron Radiation, 21(4), 768-773.
Scopus23 WoS19 Europe PMC142014 Donnelley, M., Morgan, K., Siu, K., Farrow, N., Stahr, C., Boucher, R., . . . Parsons, D. (2014). Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo. Scientific Reports, 4(3689), 1-7.
Scopus26 WoS21 Europe PMC172014 Chakraborty, R., Hampton, O. A., Shen, X., Simko, S. J., Shih, A., Abhyankar, H., . . . Parsons, D. W. (2014). Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood, 124(19), 3007-3015.
Scopus374 Europe PMC2322014 Henderson, G. E., Wolf, S. M., Kuczynski, K. J., Joffe, S., Sharp, R. R., Parsons, D. W., . . . Appelbaum, P. S. (2014). The Challenge of Informed Consent and Return of Results in Translational Genomics: Empirical Analysis and Recommendations. Journal of Law, Medicine and Ethics, 42(3), 344-355.
Scopus57 Europe PMC482014 Scollon, S., Bergstrom, K., Kerstein, R. A., Wang, T., Hilsenbeck, S. G., Ramamurthy, U., . . . Parsons, D. W. (2014). Obtaining informed consent for clinical tumor and germline exome sequencing of newly diagnosed childhood cancer patients. Genome Medicine, 6(9), 11 pages.
Scopus64 Europe PMC552014 Parsons, D. W., Roy, A., Plon, S. E., Roychowdhury, S., & Chinnaiyan, A. M. (2014). Clinical tumor sequencing: An incidental casualty of the American College of Medical Genetics and Genomics recommendations for reporting of incidental findings. Journal of Clinical Oncology, 32(21), 2203-2205.
Scopus35 Europe PMC292013 Donnelley, M., Morgan, K., Siu, K., & Parsons, D. (2013). Variability of in vivo fluid dose distribution in mouse airways is visualized by high-speed synchrotron X-ray imaging. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26(5), 307-316.
Scopus13 WoS12 Europe PMC92013 Morgan, K., Donnelley, M., Paganin, D., Fouras, A., Yagi, N., Suzuki, Y., . . . Siu, K. (2013). Measuring airway surface liquid depth in ex vivo mouse airways by X-ray imaging for the assessment of cystic fibrosis airway therapies. PLoS One, 8(1), 1-6.
Scopus21 WoS17 Europe PMC162013 Farrow, N., Miller, D., Cmielewski, P., Donnelley, M., Bright, R., & Parsons, D. (2013). Airway gene transfer in a non-human primate: Lentiviral gene expression in marmoset lungs. Scientific Reports, 3(1), 1-3.
Scopus23 WoS21 Europe PMC152012 Donnelley, M., Morgan, K., Siu, K., & Parsons, D. (2012). Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour. Journal of Synchrotron Radiation, 19(4), 551-558.
Scopus12 WoS10 Europe PMC92012 Donnelley, M., Siu, K., Jamison, R., & Parsons, D. (2012). Synchrotron phase-contrast X-ray imaging reveals fluid dosing dynamics for gene transfer into mouse airways. Gene Therapy, 19(1), 8-14.
Scopus20 WoS15 Europe PMC122012 Chavan, R. S., Patel, K. U., Roy, A., Thompson, P. A., Chintagumpala, M., Goss, J. A., . . . López-Terrada, D. H. (2012). Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma. Pediatric Blood and Cancer, 58(6), 1006-1007.
Scopus4 Europe PMC22012 Taylor, M. D., Northcott, P. A., Korshunov, A., Remke, M., Cho, Y. J., Clifford, S. C., . . . Pfister, S. M. (2012). Molecular subgroups of medulloblastoma: The current consensus. Acta Neuropathologica, 123(4), 465-472.
Scopus1510 Europe PMC11802012 Jones, S., Li, M., Williams Parsons, D., Zhang, X., Wesseling, J., Kristel, P., . . . Papadopoulos, N. (2012). Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Human Mutation, 33(1), 100-103.
Scopus260 Europe PMC2052011 Joshi, A. D., Parsons, D. W., Velculescu, V. E., & Riggins, G. J. (2011). Sodium ion channel mutations in glioblastoma patients correlate with shorter survival. Molecular Cancer, 10(1), 9 pages.
Scopus52 Europe PMC472011 Parsons, D. W., Li, M., Zhang, X., Jones, S., Leary, R. J., Lin, J. C. H., . . . Velculescu, V. E. (2011). The genetic landscape of the childhood cancer medulloblastoma. Science, 331(6016), 435-439.
Scopus616 Europe PMC5412010 Reitman, Z. J., Parsons, D. W., & Yan, H. (2010). IDH1 and IDH2: Not Your Typical Oncogenes. Cancer Cell, 17(3), 215-216.
Scopus63 Europe PMC482010 Donnelley, M., Siu, K., Morgan, K., Skinner, W., Suzuki, Y., Takeuchi, A., . . . Parsons, D. (2010). A new technique to examine individual pollutant particle and fibre deposition and transit behaviour in live mouse trachea. Journal of Synchrotron Radiation, 17(6), 719-729.
Scopus14 WoS12 Europe PMC92010 Liu, C., Wong, E., Miller, D., Smith, G., Anson, D., & Parsons, D. (2010). Lentiviral airway gene transfer in lungs of mice and sheep: successes and challenges. Journal of Gene Medicine, 12(8), 647-658.
Scopus17 WoS16 Europe PMC102010 Cmielewski, P., Anson, D., & Parsons, D. (2010). Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length. Respiratory Research, 11(1), 84-1-84-11.
Scopus49 WoS40 Europe PMC372010 Cmielewski, P., Anson, D. S., & Parsons, D. W. (2010). LONG-TERM SINGLE DOSE GENE CORRECTION OF THE BIOELECTRICAL CFTR GENE DEFECT IN CYSTIC FIBROSIS MICE. PEDIATRIC PULMONOLOGY, 247. 2009 Stocker, A., Kremer, K., Koldej, R., Miller, D., Anson, D., & Parsons, D. (2009). Single-dose lentiviral gene transfer for lifetime airway gene expression. Journal of Gene Medicine, 11(10), 861-867.
Scopus61 WoS56 Europe PMC452009 Donnelley, M., Morgan, K., Fouras, A., Skinner, W., Uesugi, K., Yagi, N., . . . Parsons, D. (2009). Real-time non-invasive detection of inhalable particulates delivered into live mouse airways. Journal of Synchrotron Radiation, 16(Part 4), 553-561.
Scopus19 WoS16 Europe PMC122009 Yan, H., Bigner, D. D., Velculescu, V., & Parsons, D. W. (2009). Mutant metabolic enzymes are at the origin of gliomas. Cancer Research, 69(24), 9157-9159.
Scopus136 Europe PMC1072009 Holdhoff, M., Parsons, W. D., & Diaz, L. A. (2009). Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer. Journal of Neuro-Oncology, 94(2), 297.
Scopus9 Europe PMC72009 Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., . . . Bigner, D. D. (2009). IDH1 and IDH2 mutations in gliomas. New England Journal of Medicine, 360(8), 765-773.
Scopus4942 Europe PMC38532009 Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., . . . Klein, A. P. (2009). Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science, 324(5924), 217.
Scopus689 Europe PMC5172008 Leary, R. J., Lin, J. C., Cummins, J., Boca, S., Wood, L. D., Parsons, D. W., . . . Velculescu, V. E. (2008). Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America, 105(42), 16224-16229.
Scopus255 Europe PMC2072008 Parsons, D. W., Jones, S., Zhang, X., Lin, J. C. H., Leary, R. J., Angenendt, P., . . . Kinzler, K. W. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science, 321(5897), 1807-1812.
Scopus4992 Europe PMC39222008 Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Angenendt, P., . . . Kinzler, K. W. (2008). Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 321(5897), 1801-1806.
Scopus3419 Europe PMC27152008 Segal, N. H., Parsons, D. W., Peggs, K. S., Velculescu, V., Kinzler, K. W., Vogelstein, B., & Allison, J. P. (2008). Epitope landscape in breast and colorectal cancer. Cancer Research, 68(3), 889-892.
Scopus366 Europe PMC2872008 Siu, K., Morgan, K., Paganin, D., Boucher, R., Uesugi, K., Yagi, N., & Parsons, D. (2008). Phase contrast X-ray imaging for the non-invasive detection of airway surfaces and lumen characteristics in mouse models of airway disease. European Journal of Radiology, 68(3), S22-S26.
Scopus33 WoS26 Europe PMC192008 Parsons, D., Morgan, K., Donnelley, M., Fouras, A., Crosbie, J., Williams, I., . . . Siu, K. (2008). High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI). Journal of Anatomy, 213(2), 217-227.
Scopus53 WoS46 Europe PMC332007 Kremer, K., Dunning, K., Parsons, D., & Anson, D. (2007). Gene delivery to airway epithetiat cells in vivo: a direct comparison of apicat and basotateral transduction strategies using pseudotyped, lentivirus vectors. Journal of Gene Medicine, 9(5), 362-368.
Scopus56 WoS53 Europe PMC532007 Parsons, D. W., Siu, K., Boucher, R. C., Uesugi, K., & Yagi, N. (2007). Non-invasive detection of airway surfaces and lumen characteristics in mouse: Dynamic changes, and ultra-CT via synchrotron Xrays. PEDIATRIC PULMONOLOGY, 238. 2007 Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., . . . Vogelstein, B. (2007). The genomic landscapes of human breast and colorectal cancers. Science, 318(5853), 1108-1113.
Scopus2691 Europe PMC20562007 Lin, J., Gan, C. M., Zhang, X., Jones, S., Sjöblom, T., Wood, L. D., . . . Velculescu, V. E. (2007). A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Research, 17(9), 1304-1318.
Scopus118 Europe PMC822006 Parsons, D., Walker, M., & Bowler, P. G. (2006). Silver: Clarifying the claims. OSTOMY WOUND MANAGEMENT, 52(6), 12-+. 2006 Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., . . . Velculescu, V. E. (2006). The consensus coding sequences of human breast and colorectal cancers. Science, 314(5797), 268-274.
Scopus2975 Europe PMC23312006 Cmielewski, P. L., Anson, D. S., & Parsons, D. W. (2006). Airway Pre-Treatment with a Novel Surfactant Compound Improves Standard Enhancement of Lentiviral Gene Transfer <i>In Vivo</i>. MOLECULAR THERAPY, 13, S268.
2006 Stocker, A. G., Anson, D. S., & Parsons, D. W. (2006). Single-Dose Lentivirus Gene Transfer In Vivo Maintains Airway Gene Expression for over Six Months. MOLECULAR THERAPY, 13, S265. 2006 Parsons, D. W., Siu, K. W., Crosbie, J., Williams, I., Richard, B. C., Uesugi, K., & Yagi, N. (2006). Towards Non-Invasive Assessment of CF Airway Gene Therapy: High Resolution Propogation-Based Imaging of Airway Surface Liquid Via Synchrotron Light. MOLECULAR THERAPY, 13, S270.
2006 Anson, D., Smith, G., & Parsons, D. (2006). Gene therapy for cystic fibrosis airway disease - Is clinical success imminent?. Current Gene Therapy, 6(2), 161-179.
Scopus14 WoS13 Europe PMC72005 Koldej, R., Cmielewski, P., Stocker, A., Parsons, D., & Anson, D. (2005). Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production. Journal of Gene Medicine, 7(11), 1390-1399.
Scopus42 WoS37 Europe PMC352005 Parsons, D. (2005). Airway gene therapy and cystic fibrosis. Journal of Paediatrics and Child Health, 41(3), 94-96.
Scopus10 WoS8 Europe PMC62005 Parsons, D. W., Wang, T. L., Samuels, Y., Bardelli, A., Cummins, J. M., DeLong, L., . . . Velculescu, V. E. (2005). Colorectal cancer: Mutations in a signalling pathway. Nature, 436(7052), 792.
Scopus511 Europe PMC3812004 Wang, Z., Shen, D., Parsons, D. W., Bardelli, A., Sager, J., Szabo, S., . . . Velculescu, V. E. (2004). Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science, 304(5674), 1164-1166.
Scopus448 Europe PMC3682004 Wang, Z., Cummins, J. M., Shen, D., Cahill, D. P., Jallepalli, P. V., Wang, T. L., . . . Lengauer, C. (2004). Three Classes of Genes Mutated in Colorectal Cancers with Chromosomal Instability. Cancer Research, 64(9), 2998-3001.
Scopus165 Europe PMC1192004 Kennedy, J., Blunden, S., Hirte, C., Parsons, D., Martin, A., Crowe, E., . . . Lushington, K. (2004). Reduced neurocognition in children who snore. Pediatric Pulmonology, 37(4), 330-337.
Scopus182 WoS144 Europe PMC1052003 Bardelli, A., Parsons, D. W., Silliman, N., Ptak, J., Szabo, S., Saha, S., . . . Velculescu, V. E. (2003). Mutational analysis of the tyrosine kinome in colorectal cancers. Science, 300(5621), 949.
Scopus443 Europe PMC3302002 Pontifex, E., Williams, M., Lunn, R., & Parsons, D. (2002). The effect of huffing and directed coughing on energy expenditure in young asymptomatic subjects. Australian Journal of Physiotherapy, 48(3), 209-213.
Scopus13 WoS6 Europe PMC52002 Limberis, M., Anson, D., Fuller, M., & Parsons, D. (2002). Recovery of airway cystic fibrosis transmembrane conductance regulator function in mice with cystic fibrosis after single-dose lentivirus-mediated gene transfer. Human Gene Therapy, 13(16), 1961-1970.
Scopus124 WoS110 Europe PMC922001 Williams, M., Parsons, D., Frick, R., Ellis, E., Martin, A., Giles, S., & Grant, E. (2001). Acute respiratory infection in patients with cystic fibrosis with mild pulmonary impairment: Comparison of two physiotherapy regimens. Australian Journal of Physiotherapy, 47(4), 227-236.
Scopus19 WoS15 Europe PMC112001 Master, V., Roberts, G., Coulthard, K., Baghurst, P., Martin, A., Roberts, M., . . . Parsons, D. (2001). Efficacy of once-daily tobramycin monotherapy for acute pulmonary exacerbations of cystic fibrosis: A preliminary study. Pediatric Pulmonology, 31(5), 367-376.
Scopus50 WoS49 Europe PMC372001 Tarran, R., Grubb, B., Parsons, D., Picher, M., Hirsch, A., Davis, C., & Boucher, R. (2001). The CF salt controversy: In vivo observations and therapeutic approaches. Molecular Cell, 8(1), 149-158.
Scopus227 WoS194 Europe PMC1802001 Limberis, M., Martella, T., Fuller, M., Anson, D. S., & Parsons, D. W. (2001). A lentiviral gene transfer vector for airway epithelium. Respirology, 6(SUPPL. 1). 2001 Parsons', D., & Skinner, W. (2001). A novel approach to examining and correlating function, structure & chemical-architecture in airway epithelium. Respirology, 6(SUPPL. 1). 2000 Parsons, D., Hopkins, P., Bourne, A., Boucher, R., & Martin, A. (2000). Airway gene transfer in mouse nasal-airways: importance of identification of epithelial type for assessment of gene transfer. Gene Therapy, 7(21), 1810-1815.
Scopus20 WoS19 Europe PMC182000 Lipsett, J., Cool, J., Runciman, S., Ford, W., Kennedy, J., Martin, A., & Parsons, D. (2000). Morphometric analysis of preterm fetal pulmonary development in the sheep model of congenital diaphragmatic hernia. Pediatric and Developmental Pathology, 3(1), 17-28.
Scopus25 WoS20 Europe PMC192000 Lipsett, J., Cool, J., Runciman, S., Ford, W., Parsons, D., Kennedy, J., & Martin, A. (2000). Effect of immediate versus slow intrauterine reduction of congenital diaphragmatic hernia on lung development in the sheep: A morphometric analysis of term pulmonary structure and maturity. Pediatric Pulmonology, 30(3), 228-240.
Scopus6 WoS6 Europe PMC42000 Badcock, N., Parsons, D., Staugas, R., Couper, R., & Aldis, J. (2000). Vitamin E, peroxidative and non-peroxidative free radical damage markers, and sample collection timing in children and adolescents with cystic fibrosis. Nutrition & Dietetics, 57(2), 79-83. 2000 Williams, M., Parsons, D., Frick, R., Ellis, E., Martin, A., Giles, S., & Grant, E. (2000). Energy expenditure during physiotherapist-assisted and self-treatment in cystic fibrosis. Physiotherapy Theory and Practice, 16(2), 57-67.
Scopus112000 Monani, U. R., Sendtner, M., Coovert, D. D., Parsons, D. W., Andreassi, C., Le, T. T., . . . Burghes, A. H. M. (2000). The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Human Molecular Genetics, 9(3), 333-339.
Scopus664 Europe PMC5062000 O'Hare, P., Bilous, R., Mitchell, T., O'Callaghan, C. J., Viberti, G., Willoughby, R., . . . Schyns, C. (2000). Low-dose ramipril reduces microalbuminuria in type 1 diabetic patients without hypertension: Results of a randomized controlled trial. Diabetes Care, 23(12), 1823-1829.
Scopus1051999 Roberts, G., Master, V., Staugas, R., Raftos, J., Parsons, D., Coulthard, K., & Martin, A. (1999). Repeated dose inhaled budesonide versus placebo in the treatment of croup. Journal of Paediatrics and Child Health, 35(2), 170-174.
Scopus19 WoS14 Europe PMC121999 Parsons, D., Martella, T., Hopkins, P., Limberis, M., & Martin, J. (1999). Lysophosphatidylcholine (LPC) provides greater enhancement of in-vivo adenoviral airway gene transfer than polidocanol. Respirology, 4(SUPPL. 1).
Scopus21998 Holland, N., Williams, M. T., Parsons, D., Hall, B., & Martin, A. J. (1998). The effect of directed vigorous coughing on energy expenditure and pulmonary function in normal subjects. Physiotherapy Theory and Practice, 14(1), 55-61.
Scopus41998 Bambini, D. A., Irish, M. S., Kapur, P., Glick, P. L., Ford, W. D. A., Cool, J. C., . . . Slater, A. J. (1998). Tracheal ligation in CDH: Bigger may not be better (multiple letters) [1]. Pediatric Surgery International, 13(7), 537-538.
Scopus3 WoS2 Europe PMC21998 Parsons, D., Grubb, B., Johnson, L., & Boucher, R. (1998). Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent. Human Gene Therapy, 9(18), 2661-2672.
Scopus82 WoS64 Europe PMC601998 Ford, W., Cool, J., Parsons, D., Martin, A., Kennedy, J., Lipsett, J., . . . Slater, A. (1998). Tracheal Ligation in CDH - Bigger May Not Be Better - Response. Pediatric Surgery International, 13(7), 538. 1998 Parsons, D. W., McAndrew, P. E., Iannaccone, S. T., Mendell, J. R., Burghes, A. H. M., & Prior, T. W. (1998). Intragenic telSMN mutations: Frequency, distribution, evidence of a founder effect, and modification of the spinal muscular atrophy phenotype by cenSMN copy number. American Journal of Human Genetics, 63(6), 1712-1723.
Scopus171 Europe PMC1161998 Parsons, D. W., McAndrew, P. E., Allinson, P. S., Parker, W. D., Burghes, A. H. M., & Prior, T. W. (1998). Diagnosis of spinal muscular atrophy in an SMN non-deletion patient using a quantitative PCR screen and mutation analysis. Journal of Medical Genetics, 35(8), 674-676.
Scopus29 Europe PMC221997 McAndrew, P. E., Parsons, D. W., Simard, L. R., Rochette, C., Ray, P. N., Mendell, J. R., . . . Burghes, A. H. M. (1997). Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMN(T) and SMN(C) gene copy number. American Journal of Human Genetics, 60(6), 1411-1422.
Scopus470 Europe PMC3601996 Parsons, D. W., McAndrew, P. E., Monani, U. R., Mendell, J. R., Burghes, A. H. M., & Prior, T. W. (1996). An 11 base pair duplication in exon 6 of the SMN gene produces a type I spinal muscular atrophy (SMA) phenotype: Further evidence for SMN as the primary SMA-determining gene. Human Molecular Genetics, 5(11), 1727-1732.
Scopus127 Europe PMC831996 Parsons, D., & Williams, M. (1996). Patient-controlled sputum removal during chest physiotherapy in cystic fibrosis: a system for use in closed-circuit assessment of energy expenditure. Medical and Biological Engineering and Computing, 34(6), 494-497.
Scopus3 WoS11996 Boros, C., Parsons, D., Zoanetti, G., Ketteridge, D., & Kennedy, D. (1996). Cannabis cookies - a cause of coma. Journal of Paediatrics and Child Health, 32(2), 194-195.
Scopus37 WoS22 Europe PMC201996 Ford, W., Cool, J., Parsons, D., Martin, A., Kennedy, J., Lipsett, J., . . . Slater, A. (1996). Congenital diaphragmatic hernia : lung compliance after antenatal tracheal obstruction or surgical correction of the defect. Pediatric Surgery International, 11(8), 524-527.
Scopus6 WoS6 Europe PMC41995 Kennedy, J., Staples, A., Brook, P., Parsons, D., Sutherland, A., Martin, A., . . . Foster, B. (1995). Effect of spinal surgery on lung function in Duchenne muscular dystrophy. Thorax, 50(1), 1173-1178.
Scopus83 WoS60 Europe PMC461994 Parsons, D. W., Martin, A. J., Staugas, R. E. M., Kennedy, J. D., Ford, W. D. A., & Cool, J. C. (1994). Fetal lung compliance in premature and term lambs after two methods of in utero repair of diaphragmatic hernia. Thorax, 49(10), 1015-1019.
Scopus9 WoS8 Europe PMC71994 Ferrante, A., Martin, A. J., Bates, E. J., Kowanko, I. C., Harvey, D. P., Parsons, D., . . . Dayer, J. M. (1994). Interaction of Staphylococcus aureus with human neutrophils and the down-regulation of TNF receptors. Journal of Immunology, 152(8), 3998-4004.
Scopus15 WoS17 Europe PMC81993 Ford, W. D. A., Martin, A. J., Cool, J. C., Parsons, D. W., & Kennedy, J. D. (1993). Intrathoracic silo for fetal diaphragmatic hernia: Lung growth and slow reduction of abdominal viscera. Journal of Pediatric Surgery, 28(8), 1006-1008.
Scopus7 WoS7 Europe PMC61993 PARSONS, D. W., CARMAN, K., MOORE, L. M., MARTIN, A. J., STAUGAS, R. E., RATHJEN, D. A., & FERRANTE, A. (1993). A PEPTIDE OF TUMOR-NECROSIS-FACTOR-ALPHA MAY MODULATE CHRONIC PSEUDOMONAL LUNG INFLAMMATION. AMERICAN REVIEW OF RESPIRATORY DISEASE, 147(4), A730. 1993 PARSONS, D. W., MARTIN, A. J. M., FORD, W. D. A., COOL, J., & KENNEDY, J. D. (1993). STATIC LUNG COMPLIANCE IS IMPROVED BY INUTERO SILO REPAIR OF FETAL LAMB DIAPHRAGMATIC-HERNIA. AMERICAN REVIEW OF RESPIRATORY DISEASE, 147(4), A416. 1993 Ferrante, A., Martin, A. J., Bates, E. J., Goh, D. H. B., Harvey, D. P., Parsons, D., . . . Dayer, J. M. (1993). Killing of Staphylococcus aureus by tumor necrosis factor-α-activated neutrophils: The role of serum opsonins, integrin receptors, respiratory burst, and degranulation. Journal of Immunology, 151(9), 4821-4828.
Scopus86 WoS87 Europe PMC581993 MARTIN, A. J., FERRANTE, A., BATES, E. J., HARVEY, D. P., PARSONS, D., KOWANKO, I. C., . . . DAYER, J. M. (1993). DOWN-REGULATION OF NEUTROPHIL TUMOR-NECROSIS-FACTOR (TNF) RECEPTORS BY STAPHYLOCOCCUS. JOURNAL OF LEUKOCYTE BIOLOGY, 83. 1990 Parsons, D. W., & Macmillan, D. L. (1990). The effect of carbon monoxide on the function of a crustacean sensory receptor is no different to the effect of hypoxia. Research Communications in Chemical Pathology and Pharmacology, 67(2), 229-240. 1990 Helps, S. C., Parsons, D. W., Reilly, P. L., & Gorman, D. F. (1990). The effect of gas emboli on rabbit cerebral blood flow. Stroke, 21(1), 94-99.
Scopus106 WoS81 Europe PMC621989 Parsons, D. W., & Pinsker, H. M. (1989). Swimming in Aplysia brasiliana: Behavioral and cellular effects of serotonin. Journal of Neurophysiology, 62(5), 1163-1176.
Scopus25 WoS34 Europe PMC171989 Ferguson, G. P., Ter Maat, A., Parsons, D. W., & Pinsker, H. M. (1989). Egg laying in Aplysia - I. Behavioral patterns and muscle activity of freely behaving animals after selectively elicited bag cell discharges. Journal of Comparative Physiology A, 164(6), 835-847.
Scopus28 WoS31 Europe PMC181988 Gorman, D. F., Harding, P. E., Roberts, A. P., Gilligan, J. E., Capps, R. A., & Parsons, D. W. (1988). Topical hyperbaric oxygen for treatment of diabetic foot ulcers. Diabetes Care, 11(10), 819.
Scopus2 WoS2 Europe PMC11988 RUNCIMAN, W. B., GORMAN, D. F., WEBB, R. K., RUSSELL, W. J., GILLIGAN, J. E., & PARSONS, D. W. (1988). DIFFERING OPINIONS ON HYPERBARIC-OXYGEN THERAPY. CHEST, 94(3), 671-672.
1988 Parsons, D. W., & Pinsker, H. M. (1988). Swimming in Aplysia Brasiliana: Identification of parapodial opener-phase and closer-phase neurons. Journal of Neurophysiology, 59(3), 717-739.
Scopus10 Europe PMC71986 Ferguson, G. P., Parsons, D. W., Ter Maat, A., & Pinsker, H. M. (1986). Spontaneous and elicited bag cell discharges in gonadectomized Aplysia. Journal of Experimental Biology, VOL. 123(1), 159-173.
Scopus13 WoS16 Europe PMC81985 Pinsker, H. M., & Parsons, D. W. (1985). Temperature dependence of egg laying in Aplysia brasiliana and A. californica. Journal of Comparative Physiology B, 156(1), 21-27.
Scopus26 WoS29 Europe PMC141985 Pearson, K. G., Reye, D. N., Parsons, D. W., & Bicker, G. (1985). Flight-initiating interneurons in the locust. Journal of Neurophysiology, 53(4), 910-925.
Scopus38 WoS44 Europe PMC211983 Parsons, D. W., Ter Maat, A., & Pinsker, H. M. (1983). Selective recording and stimulation of individual identified neurons in freely behaving Aplysia. Science, 221(4616), 1203-1206.
Scopus18 WoS26 Europe PMC91982 Porten, K. V. D., Parsons, D. W., Rothman, B. S., & Pinsker, H. (1982). Swimming in Aplysia brasiliana: Analysis of behavior and neuronal pathways. Behavioral and Neural Biology, 36(1), 1-23.
Scopus20 WoS31 Europe PMC121982 Parsons, D. W. (1982). Responses and central interactions of tension receptors in the leg flexor muscle of Carcinus. Comparative Biochemistry and Physiology -- Part A: Physiology, 72(2), 391-399.
Scopus12 WoS151982 Parsons, D. W., & Mosse, P. R. I. (1982). The leg flexor muscle of Carcinus. II. Distribution of muscle fiber types. Journal of Experimental Zoology, 224(2), 169-175.
Scopus22 WoS201982 Parsons, D. W. (1982). The leg flexor muscle of Carcinus. I. Innervation and excitatory neuromuscular physiology. Journal of Experimental Zoology, 224(2), 157-168.
Scopus23 WoS201980 Parsons, D. W. (1980). The morphology and ultrastructure of tension receptors in the walking legs of the crab, Carcinus maenas. Cell and Tissue Research, 211(1), 139-149.
Scopus10 WoS15 Europe PMC41979 Parsons, D. W. (1979). A centrally programmed neural response in the abalone, Haliotis laevigata. Comparative Biochemistry and Physiology -- Part A: Physiology, 63(1), 75-78.
1979 PARSONS, D. W., & MACMILLAN, D. L. (1979). ESCAPE RESPONSE OF ABALONE (MOLLUSCA, PROSOBRANCHIA, HALIOTIDAE) TO PREDATORY GASTROPODS. MARINE BEHAVIOUR AND PHYSIOLOGY, 6(1), 65-82.
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Books
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Book Chapters
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Conference Papers
Year Citation 2024 Parsons, D., Bruorton, M., Phillips, J., Eikelis, N., Nilsen, K., Carson-Chahoud, K., . . . Goddard, T. (2024). Lung ventilation via x-ray velocimetry imaging and PFTs in CF children: Case-studies from the ongoing Adelaide pilot and feasibility trial. In RESPIROLOGY Vol. 29 (pp. 11). WILEY. 2024 Reyne, N., Cmielewski, P., Smith, R., Eikelis, N., Nilsen, K., Mall, M., . . . Donnelley, M. (2024). X-ray Velocimetry detects peripheral lung ventilation defects in ßENaC mice. In RESPIROLOGY Vol. 29 (pp. 166). WILEY. 2024 Bruorton, M., Carson-Chahhoud, K., Donnelley, M., Goddard, T., O'Connor, A., Parsons, D., . . . Tai, A. (2024). Feasibility study of x-ray Velocimetry imaging in children with CF. In RESPIROLOGY Vol. 29 (pp. 225). WILEY. 2021 Jayapal, M., Tran H, B., Maiolo, S., Reynolds, P., Liu, H., Parsons, D., . . . Hodge, S. (2021). PYOCYANIN INCREASES VASCULAR RAC1/ZIP12/BMPR2-RELEVANCE TO VASCULAR DYSFUNCTION AND REMODELLING IN CYSTIC FIBROSIS. In RESPIROLOGY Vol. 26 (pp. 59). WILEY. 2021 Donnelly, M., Christou, C., Finnie, J., Dustng, J., Khanlou, S., Fouras, A., & Parsons, D. (2021). DETECTION OF LOCALLY-ALTERED AIRFLOW BY X-RAY VELOCIMETRY (XV) IN PIGS FOR ARDS-LIKE DISEASE MODELLING OF COVID-19 LUNG INJURY. In RESPIROLOGY Vol. 26 (pp. 30). WILEY. 2021 Reyne, N., Cmielewski, P., Mccarron, A., Parsons, D., & Donnelley, M. (2021). LENTIVIRAL AIRWAY GENE-ADDITION CORRECTS CF RAT NASAL ION CHANNEL FUNCTION. In RESPIROLOGY Vol. 26 (pp. 156). WILEY. 2019 Gardner, M., Donnelley, M., Parsons, D., Morgan, K., McCarron, A., & Cmielewski, P. (2019). Neural Networks provide superior detection of particles in Synchrotron X-ray images for automated Mucociliary Transport measurement. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). online: IEEE. 2019 McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. In MOLECULAR THERAPY Vol. 27 (pp. 209). Washington, DC: CELL PRESS. 2019 Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. W. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers.
DOI Scopus12019 Li, J., Quirk, B. C., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. A. (2019). Imaging genetically-modified cells with a miniaturised multimodal optical coherence tomography + fluorescence probem. In Proceedings of the 2019 IEEE Photonics Conference (IPC) (pp. 1-2). Piscataway, NJ: IEEE.
DOI2019 Parsons, D., Cmielewski, P., Mccarron, A., Mcintyre, C., Craig, F., Finnie, J., . . . Donnelley, M. (2019). Update on the Australian cystic fibrosis rat colony. In Respirology Vol. 24 (pp. 136). Broadbeach, Qld.: Wiley. 2019 Macowan, M., Tran, H., Matthews, K., Ralph, M., Donnelley, M., Parsons, D., & Hodge, S. (2019). DYSREGULATED S1P SIGNALLING IN MOUSE MODEL OF CYSTIC FIBROSIS-LIKE LUNG DISEASE PRODUCED BY βENAC OVEREXPRESSION. In RESPIROLOGY Vol. 24 (pp. 118). WILEY. 2018 Gradl, R., Dierolf, M., Hehn, L., Gunther, B., Kutschke, D., Yang, L., . . . Morgan, K. (2018). Dynamic x-ray imaging at the Munich Compact Light Source. In Microscopy and Microanalysis Vol. 24 (pp. 350-351). Saskatoon, Canada: MIcroscopy Society of America.
DOI2017 Jung, H., Lee, I., Lee, S., Parsons, D., & Donnelley, M. (2017). Multiple mucociliary transit marker tracking in synchrotron X-ray images using the global nearest neighbor method. In Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC' 17) Vol. 2017 (pp. 1824-1827). Online: IEEE.
DOI Scopus2 WoS32016 McCarron, A., McIntyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2016). Development of a Clinically-Acceptable Lentiviral Vector for Cystic Fibrosis Airway Gene Therapy. In MOLECULAR THERAPY Vol. 24 (pp. S280-S281). Washington, DC: NATURE PUBLISHING GROUP.
DOI2016 Donnelley, M., Morgan, K., Farrow, N., Siu, K., & Parsons, D. (2016). Non-invasive airway health measurement using synchrotron X-ray microscopy of high refractive index glass microbeads. In M. D. DeJonge, D. J. Paterson, & C. G. Ryan (Eds.), AIP Conference Proceedings Vol. 1696 (pp. 4 pages). Australian Synchrotron, Melbourne, AUSTRALIA: AMER INST PHYSICS.
DOI Scopus8 WoS62016 Parsons, D., & Robar, J. (2016). Continuous Intra-Fractional Monitoring of the Prostate Using Dynamic KV Collimation and Tube Current Modulation. In MEDICAL PHYSICS Vol. 43 (pp. 3684). Washington, DC: WILEY.
DOI WoS12012 Morgan, K., Paganin, D., Parsons, D., Donnelly, M., Yagi, N., Uesugi, K., . . . Siu, K. (2012). Single grating x-ray imaging for dynamic biological systems. In International Workshop on X-Ray and Neutron Phase Imaging with Gratings Vol. 1466 (pp. 124-129). United States: Springer New York LLC.
DOI Scopus3 WoS32010 Donnelley, M., Parsons, D., Morgan, K., & Siu, K. (2010). Animals In synchrotrons: overcoming challenges for high-resolution, live, small-animal imaging. In K. Siu (Ed.), Proceedings of 6th International Conference on Medical Applications of Synchrotron Radiation Vol. 1266 (pp. 30-34). United States: American Institute of Physics.
DOI Scopus19 WoS132009 Morgan, K., Paganin, D., Parsons, D., Donnelley, M., Yagi, N., Uesugi, K., . . . Siu, K. (2009). Optimising coherence properties for phase contrast x-Ray imaging (PCXI) to reveal airway surface liquid (ASL) as an airway health measure. In IFMBE Proceedings Vol. 25 (pp. 135-138). Munich, Germany: Springer Verlag.
DOI Scopus2 WoS22009 Cmielewski, P. L., Anson, D. S., & Parsons, D. W. (2009). Six Months Lentiviral Correction of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Defect in Cystic Fibrosis Mice. In MOLECULAR THERAPY Vol. 17 (pp. S122). San Diego, CA: NATURE PUBLISHING GROUP. 2007 Kremer, K., Anson, D., & Parsons, D. (2007). Inhibition of the innate immune response to lentivirus mediated gene transfer with leptomycin B. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 530). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2007 Buckley, S., Howe, S., Sheard, V., Anson, D., Parsons, D., Thrasher, A., . . . McKay, T. (2007). Significant airway transduction after <i>in utero</i> administration of a gp64 pseudotyped lentiviral vector. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 526). Shine Dome Acad Sci, Canberra, AUSTRALIA: WILEY-BLACKWELL.
DOI2007 Parsons, D., Siu, K., Williams, I., Boucher, R., Uesugi, K., & Yagi, N. (2007). Non-invasive X-ray imaging of mouse airways and organs at very high resolution - A new option for gene expression studies?. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 531-532). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2007 Liu, C., Wong, E., Tan, C. K., Anson, D., & Parsons, D. (2007). Effects of LPC pre-dosing on lentiviral gene expression in mouse lung. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 538). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2005 Cmielewski, P., Parsons, D. W., Stocker, A., & Anson, D. S. (2005). <i>In vivo</i> airway conditioning for improved gene delivery:: Mucosubstance release and lentiviral gene transfer. In JOURNAL OF GENE MEDICINE Vol. 7 (pp. 1135). Melbourne, AUSTRALIA: JOHN WILEY & SONS LTD. -
Conference Items
Year Citation 2023 Li, D., Habgood, M., Reyne, N., Cmielewski, P., McCarron, A., Parsons, D., . . . Schneider-Futschik, E. (2023). Cystic fibrosis modulator triple combination in pregnancy and lactation: Effects on the developing lung, gut and pancreas. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science (TSANZSRS, 2023) as published in Respirology. Christchurch, Aotearoa New Zealand: Wiley. 2023 Rout-Pitt, N., Mc Carron, A., Boog, B., Parsons, D., & Donnelley, M. (2023). A twist in the cystic fibrosis story—TGF-β1 treatment affects epithelialmesenchymal transition differentially in two cystic fibrosis rat airway cell models. Poster session presented at the meeting of North American Cystic Fibrosis Conference. 2022 Reyne, N., Cmielewski, P., Boog, B., McCarron, A., Parsons, D., & Donnelley, M. (2022). Cystic fibrosis rat models demonstrate altered respiratory mechanics. Poster session presented at the meeting of Abstracts of the The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ), Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science (TSANZSRS, 2022), as published in Respirology. virtual online: Wiley.
DOI2021 Tran, H., Jayapal, M., Donnelley, M., Parsons, D., & Parsons, D. (2021). MECHANISMS LEADING TO PULMONARY VASCULAR DISORDERS MAY ARISE BEFORE FULL PENETRATION OF LUNG DISEASE IN CF RATS. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2020 Reyne, N., Cmielewski, P., McCarron, A., Parsons, D., & Donnelley, M. (2020). Measuring CFTR Function in CF Rats: Optimisation of the Nasal Potential Difference Technique. Poster session presented at the meeting of Abstracts of the the 34th Annual North American Cystic Fibrosis Conference (NACFC 2020), as published in Pediatric Pulmonology. Phoenix, Arizona and virtual online: Wiley.
DOI2020 Dusting, J., Donnelley, M., Parsons, D., & Fouras, A. (2020). DEDICATED XV HUMAN SCANNER DELIVERING 4D REGIONAL LUNG FUNCTION ANALYSIS WITH A LOWER DOSE THAN CHEST X-RAY. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2019 Tran, H. B., Macowan, M., Abdo, A., Donnelley, M., Parsons, D., & Hodge, S. (2019). Airway inflammasome activation and dysregulated S1P signalling associated with mucus obstruction in a cystic fibrosis-like mouse model.. Poster session presented at the meeting of Respirology. Wiley. 2019 Werdiger, F., Morgan, K. S., Dusbky, S., Cmielewski, P., Kitchen, M., Klein, M., . . . Donnelley, M. (2019). Quantification of local lung disease in rat models of CF disease and CF knockout mice. Poster session presented at the meeting of Pediatric Pulmonology. Nashville, Tennessee: Wiley. 2019 Rout-Pitt, N., Donnelley, M., & Parsons, D. (2019). OPTIMISATION OF BRONCHOSCOPIC LENTIVIRAL VECTOR DELIVERY FOR DIRECT LOBE TARGETING IN RAT LUNGS. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Werdiger, F., Donnelley, M., Parsons, D., Morgan, K. S., Samarage, C. R., Carnibella, R., & Fouras, A. (2018). QUANTIFICATION OF REGIONAL LUNG DISEASE IN β-ENAC MICE USING A LABORATORY X-RAY SOURCE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 McIntyre, C., Rout-Pitt, N., Donnelley, M., & Parsons, D. (2018). LOBE SPECIFIC TARGETING OF LENTIVIRAL VECTOR GENE TRANSFER TO THE LUNGS OF ADULT RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 McIntyre, C., Cmielewski, P., Craig, F., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). CF-RELATED PATHOLOGIES ARE MORE SEVERE IN KNOCKOUT RATS COMPARED TO PHE508DEL RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 Donnelley, M., Klein, M., Hausermann, D., Hall, C., Maksimenko, A., Morgan, K., & Parsons, D. (2018). Non-invasive mucociliary transit assessment in live pig trachea. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Adelaide, Australia: Wiley.
DOI2018 Mcintyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2018). GENERATION OF NEW CYSTIC FIBROSIS RAT MODELS IN AUSTRALIA. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Carpentieri, C., Farrow, N., Mcintyre, C., Cmielewski, P., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS FOR CYSTIC FIBROSIS AIRWAY GENE THERAPY. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Farrow, N., Cmielewski, P., Donnelley, M., Bertoncello, I., & Parsons, D. (2018). DOES EPITHELIAL ABLATION IN THE NASAL AIRWAYS OF MICE IMPROVE STEM CELL ENGRAFTMENT?. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Donnelley, M., & Parsons, D. (2018). HOW DO WE KNOW IF CYSTIC FIBROSIS LUNG GENE THERAPY WORKS? THE IMPORTANCE OF THE RIGHT ANIMAL MODEL, AND THE RIGHT MEASUREMENT METHOD. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY. 2018 Carpentieri, C., Farrow, N., Cmielewski, P., McIntyre, C., McCarron, A., Rout-Pitt, N., . . . Donnelley, M. (2018). Airway Gene-Addition Therapy for Cystic Fibrosis: the VSV-G Pseudotype Produces Higher Transduction Levels Than HA. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. 2018 Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Bertoncello, I., & Parsons, D. (2018). Epithelial Disruption Enables Human Airway Stem Cell Transplantation in Mouse Nasal Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. 2017 Farrow, N., Donnelley, M., McIntyre, C., Rout-Pitt, N., & Parsons, D. (2017). Developing high efficiency gene transfer techniques using human air liquid interface cultures. Poster session presented at the meeting of TSANZ Poster presentations, as published in Respirology. Canberra: Wiley. 2017 McIntyre, C., Donnelley, M., Cmielewski, P., & David, P. W. (2017). Generation of new cystic fibrosis rat models in Australia developed using CRISPR/Cas9 genome editing. Poster session presented at the meeting of Pediatric Pulmonology. Indianapolis, Indiana: Wiley.
DOI WoS12017 McCarron, A., Rout-Pitt, N., McIntyre, C., Donnelley, M., & Parsons, D. W. D. (2017). Lentivirus Production in Stirred-Tank and Packed-Bed Basket Bioreactor Systems: A Comparison. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. 2017 Farrow, N., Donnelley, M., Rout-Pitt, N., McIntyre, C., Bertoncello, I., & Parsons, D. W. D. (2017). High Efficiency <i>In Vitro</i> Transduction of Human Airway Basal Cells. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. 2017 Farrow, N., Cmielewski, P., Donnelley, M., & Parsons, D. (2017). HIGH EFFICIENCY LENTIVIRAL HUMAN AIRWAY BASAL CELL TRANSDUCTION. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2017 Carpentieri, C. L., Farrow, N., McIntyre, C., McCarron, A., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2017). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS DEVELOPED FOR TREATING CYSTIC FIBROSIS LUNG DISEASE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2017 Werdiger, F., Murrie, R., Kitchen, M., Samarage, C., Carnibella, R., Fouras, A., . . . Parsons, D. (2017). Detection of regional lung disease in β-ENaC mice on a laboratory x-ray source. Poster session presented at the meeting of Abstracts of the 31st Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Indianapolis, Indiana: Wiley-Blackwell.
DOI2016 Donnelley, M., Morgan, K., & Parsons, D. W. (2016). DIRECT X-RAY MEASUREMENT OF AIRWAY SURFACE HEALTH IN ANIMAL MODELS: AN UPDATE ON THE STATE-OF-THE-ART. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2016 Cmielewski, P., & Parsons, D. W. (2016). RAPID IN VIVO NASAL TRANSEPITHELIAL POTENTIAL DIFFERENCE MEASUREMENT IN MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V., . . . Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 McIntyre, C., Craig, F., Cmielewski, P., Donnelley, M., Farrow, N., & Parsons, D. (2015). Comparing the Efficacy of Tat-Dependent and Tat-Independent Lentiviral Vectors. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
DOI2015 Devereux, S., Cmielewski, P., Farrow, N., & Parsons, D. (2015). Airway Pre-Treatment Enhances Mouse Lung Lentiviral Reporter Gene Expression. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
DOI2015 Kicic, A., Ling, K., Martinovich, K., Garratt, L. W., Looi, K., Kicic-Starcevich, E., . . . Moodley, Y. (2015). CORRECTIVE EFFECTS ON AIRWAY EPITHELIAL FUNCTION BY HUMAN AMNIOTIC EPITHELIAL CELLS (HAEC) WHEN TREATING CYSTIC FIBROSIS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Farrow, N. R., McQualter, J., Donnelley, M., Cmielewski, P., Bertoncello, I., & Parsons, D. (2015). CYSTIC FIBROSIS MOUSE MODELS DISPLAY AGE DEPENDENT AIRWAY STEM/PROGENITOR CELL HYPERPLASIA. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Cmielewski, P., Parsons, D., Donnelley, M., Padmanabhan, H., Ling, K., Stick, S. M., . . . Moodley, Y. (2015). DELIVERY OF HUMAN AMNIOTIC STEM CELLS CORRECTS CFTR FUNCTION IN CF MOUSE NASAL AIRWAYS IN VIVO. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Farrow, N. R., McQualter, J. L., Donnelley, M., Bertoncello, I., & Parsons, D. W. (2014). GENE THERAPY FOR CF: IS LONG TERM EXPRESSION A CONSEQUENCE OF TRANSDUCING CONDUCTING AIRWAY ENDOGENOUS RESPIRATORY STEM CELLS?. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Padmanabhan, H., Cmielewski, P., Donnelley, M., & Parsons, D. (2014). IMPROVING THE TRANSDUCTION EFFICIENCY OF AN AEROSOL DELIVERED LENTIVIRAL VECTOR FOR CYSTIC FIBROSIS LUNG GENE THERAPY. Poster session presented at the meeting of JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. MARY ANN LIEBERT, INC. 2014 Stahr, C. S., Samarage, C. R., Parsons, D. W., Dubsky, S., Donnelley, M., Thurgood, J., . . . Fouras, A. (2014). Regional Image Based Pulmonary Function Testing Detects Cf Lung Disease Earlier Than Conventional Pft. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. 2014 Cmielewski, P., Farrow, N., McIntyre, C., Padmanabhan, H., Donnelley, M., Kuchel, T., & Parsons, D. W. (2014). Lentiviral Airway Gene Transfer in Normal Ferrets. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: NATURE PUBLISHING GROUP. 2013 Cmielewski, P., & Parsons, D. W. (2013). CF mouse survival is improved by airway lentiviral CFTR gene transfer. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
DOI2013 Farrow, N., McQualter, J., Parsons, D., & Bertoncello, I. (2013). Endogenous stem/progenitor cell compartments of conducting airways differ in cystic fibrosis and normal mice. Poster session presented at the meeting of HUMAN GENE THERAPY. Univ London, Royal Holloway, Egham, ENGLAND: MARY ANN LIEBERT INC. 2013 Morgan, K., Donnelley, M., Fouras, A., Siu, K., & Parsons, D. (2013). Changes in airway surface liquid depth imaged after aerosolized hypertonic saline. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
DOI2013 Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N., Chua, C., Fouras, A., & Parsons, D. (2013). In-vivo changes in mucociliary transport after aerosols. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
DOI2012 Morgan, K. S., Donnelley, M., Fouras, A., Parsons, D., & Siu, K. (2012). SYNCHROTRON PHASE CONTRAST X-RAY IMAGING CAN DETECT AIRWAY SURFACE LIQUID DEPTH CHANGES FOLLOWING AEROSOLISED HYPERTONIC SALINE TREATMENT. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Siu, K., Chua, C. S., Donnelley, M., Morgan, K. S., Farrow, N., Mall, M. A., . . . Fouras, A. (2012). REGIONAL MEASURES OF LUNG FUNCTION IN THE β-ENAC MOUSE OBTAINED USING X-RAY IMAGING VELOCIMETRY. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). Distribution, dynamics and variability of fluid doses into live mouse lungs is revealed using high resolution synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 2012 Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meetings, as published in Respirology. Canberra, Australia: Wiley-Blackwell.
DOI2012 Parsons, D., Karen, S., Kaye, M., & Donnelley, M. (2012). High Speed X-Ray Imaging Reveals Dosed Fluid Dynamics and Fate in Mouse Nasal and Lung Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Philadelphia, PA: NATURE PUBLISHING GROUP. 2012 Cmielewski, P., & Parsons, D. W. (2012). AIRWAY LENTIVIRAL CFTR GENE TRANSFER EXTENDS THE LIFETIME OF CF MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 McQualter, J., Farrow, N., Parsons, D., & Bertoncello, I. (2012). ENDOGENOUS LUNG EPITHELIAL STEM/PROGENITOR CELL COMPARTMENTS DIFFER IN CYSTIC FIBROSIS AND NORMAL MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). HIGH FRAME RATE IMAGING OF NASAL FLUID DOSING DYNAMICS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2011 Cmielewski, P., & Parsons, D. W. (2011). BIOLUMINESCENCE GENE EXPRESSION WITH A LENTIVIRAL VECTOR IN AIRWAYS OF CYSTIC FIBROSIS MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2011 Donnelley, M., Siu, K. K., Morgan, K. S., & Parsons, D. W. (2011). DRY DEPOSITION OF POLLUTANT AND MARKER PARTICLES ONTO LIVE MOUSE AIRWAY SURFACES REVEALS HETEROGENEOUS MUCOCILIARY TRANSIT BEHAVIOUR. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2009 Donnelley, M. W., Morgan, K., Fouras, A., Skinner, W., Uesugi, K., Yagi, N., . . . Parsons, D. W. (2009). Individual particulate mucociliary transit analysis using synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 23rd Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Minneapolis, Minn.: Wiley-Liss.
DOI2007 Liu, C., Wong, E., Tan, C., Anson, D., Smith, G., & Parsons, D. W. (2007). <i>In-vivo</i> mouse and sheep lung gene transfer with a VSV-G pseudotyped lentivirus vector after LPC-pretreatment. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-LISS. -
Preprint
Year Citation 2024 McCarron, A., Ling, K. -M., Montgomery, S., Martinovich, K., Cmielewski, P., Rout-Pitt, N., . . . Donnelley, M. (2024). Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway models.
DOI
Funding
NHMRC Research Funding
| 2016 | Project Grant - 1098127 | Identifying the role of airway stem cells in maintaining lentiviral mediated gene expression for cystic fibrosis lung disease | $814,272.20 |
| 2015 | Project - APP1079712 | Revolutionising the diagnosis and monitoring of CF lung disease | $792,777.95 |
| 2013 | Development Grants - APP1055116 | From the synchrotron to the clinic: translation of a novel functional lung imaging technology | $859,797.00 |
Other Research Funding
| 2015 | International - FOURAS15GI0 | CIB | USA CF Foundation | $127,000.00 |
| 2015 | Cure4CF Foundation, Ltd | CIA | Philanthropic | $152,000.00 |
| 2015 | International - PARSON15G0 | CIA | USA CF FOUNDATION | $275,000.00 |
| 2014 | Supplemental support | Team Leader, CIA | Philanthropic - Cure4CF Foundation, Scott family trust | $230,000.00 |
| 2014 | NGO's (non-profit) | CIB | Women's & Children's Hospital Foundation | $69,687.00 |
| 2013 | Supplement Support - Philanthropic | Team Leader, CIA | WCH Foundation / Scott family trust | $250,000.00 |
| 2012 | 366-13110843 - University | CIA | Centre for Stem Cell Research (CSCR) | $64,000.00 |
| 2012 | NGO's (non-profit) | CIB | WCH Foundation | $43,754.00 |
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 - 2024 Co-Supervisor Novel Tools and Models for In-vivo Assessment of Lung Health in Cystic Fibrosis Doctor of Philosophy Doctorate Full Time Mrs Nikki Reyne 2016 - 2021 Principal Supervisor Overcoming Challenges to Development of a Lentiviral-Mediated Airway Gene-Addition Therapy for Cystic Fibrosis Doctor of Philosophy Doctorate Full Time Miss Alexandra Sarah Ann Mc Carron 2014 - 2014 Co-Supervisor Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Dr Chantelle McIntyre 2013 - 2019 Principal Supervisor Development of Lentiviral Airway Gene Therapy Aerosol Delivery Techniques for Cystic Fibrosis Doctor of Philosophy Doctorate Full Time Ms Harshavardini Padmanabhan 2011 - 2015 Principal Supervisor Cystic Fibrosis: The role of airway stem cells in sustained gene expression by lentiviral directed gene therapy Doctor of Philosophy Doctorate Full Time Dr Nigel Farrow 2006 - 2013 Principal Supervisor Longevity of Airway Gene Therapy for Cystic Fibrosis: Single and Repeat Lentiviral Dosing Doctor of Philosophy Doctorate Part Time Dr Patricia Lucia Cmielewski 2006 - 2010 Co-Supervisor Cystic Fibrosis Gene Therapy: Methods for the Optimisation of CFTR Gene Delivery Doctor of Philosophy Doctorate Full Time Mrs Karlea Lee Kremer 2004 - 2010 Co-Supervisor Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression Doctor of Philosophy Doctorate Part Time Ms Alice Stocker 1998 - 2003 Principal Supervisor A LENTIVIRAL GENE TRANSFER VECTOR FOR THE TREATMENT OF CYSTIC FIBROSIS AIRWAY DISEASE Doctor of Philosophy Doctorate Full Time Dr Maria Limberis
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Committee Memberships
Date Role Committee Institution Country 2012 - ongoing Member Imaging and Medical, Programme Advisory Committee (PAC) Australian Synchrotron - 2010 - ongoing Founder Management Committee National Non-Human Primate Breeding and Research Facility - 2009 - ongoing Member Animal studies establishment committee Australian Synchrotron - 2009 - ongoing Member Australian and New Zealand Society of Respiratory Science - - -
Memberships
Date Role Membership Country 2003 - ongoing - American Society of Gene and Cell Therapy - 2003 - ongoing - Australian Gene Therapy Society - 1991 - ongoing - Australia and New Zealand Society for Respiratory Science - 1991 - ongoing - Thoracic Society of Australia and New Zealand - 1990 - ongoing - South Australian Medical Scientists Association - -
Consulting/Advisories
Date Institution Department Organisation Type Country 2009 - ongoing Australian Synchrotron - - - 2008 - 2013 American Society of Gene and Cell Therapy - - -
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