Associate Professor David Parsons
Chief Medical Scientist
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor David Parsons, Chief Medical Scientist. TITLEHOLDER
Associate Professor David Parsons is the leader of the Cystic Fibrosis Stream at the Children's Research Centre and Chief Medical Scientist in the Department of Respiratory And Sleep Medicine at the Women's and Children's Hospital. He is also Head of the Adelaide Cystic Fibrosis Gene Therapy Group at the Robinson Institute, and an Affiliate Senior Lecturer in the Discipline of Paediatrics at the University of Adelaide.
Associate Professor David Parsons has devoted the past 25 years to finding a cure for Cystic Fibrosis (CF) airway disease and has twice-won Service Excellence Awards administered by the Women's and Children's Health Network for his innovations in this and related fields. He is a Fellow of the ANZSRS. He and his research team have pioneered a ground-breaking gene therapy technique that has been successful in reversing the basic cellular defect that causes CF in mouse models, and that holds promise as a long-lasting treatment for CF lung disease.
He was also responsible for initiating and championing leading-edge research into the surface behaviour of airways in health and disease using non-invasive synchrotron X-ray imaging techniques. By monitoring the ASL and microscopic particles previously considered too small to view in living airways, David hopes to pioneer new and more effective ways of measuring the success of respiratory treatments like gene therapy in CF patients.
David's development of CF airway gene transfer methods were supported initially by the USA CF Foundation, and have evolved to also attract funding from other funding bodies, including the National Health and Medical Research Council in Australia.
Research
Since the mid 1990's I have been developing airway gene transfer methods to achieve a safe and effective treatment or cure for clinical use for the lung disease of cystic fibrosis. I have led the Adelaide CF Airway Gene Therapy group since establishing it in 1997. My establishment of reliable and effective in-vivo airway gene vector dosing and gene expression measurement has been coupled with developing effective, rapid and non-invasive measurement of airway health in CF airways using synchrotron and other X-rays along with other in-vivo imaging such as biophotonic techniques based on luciferase gene transfer.
My interest and expertise space three themes.
(1) Development of novel analysis methods with potentially wide applicability. Starting with novel measurements of single-neuron activity in the Aplysia animal model in-vivo (Science 221, 1203-, 1983), now I am championing development of synchrotron X-ray imaging to investigate animal airway health and physiology in-vivo.
(2) Enablement of practical advances in medical therapy with potentially fundamental value, demonstrated by the >16 years efforts in development of airway gene transfer for treatment or cure of CF airway disease. This theme has advanced into the translational preclinical arena with initial trials of airway gene transfer in a non-human primate lung model (the marmoset).
(3) The last theme is the fostering of new and often cross-discipline collaborations, local and worldwide. My expansion into synchrotron X-ray physics to develop new airway health outcome measurements, based at the Japanese SPring-8 synchrotron, is an obvious example.
I continually supervise Honors and PhD students to foster new research careers, and I played a key role in establishing a community-based research Foundation (www.cure4cf.org) that has supplemented and supported the continuity, resilience, and bridging-salary needs of our CF airway gene therapy research program.
-
Appointments
Date Position Institution name 2008 - ongoing Chief Medical Scientist Women's and Children's Hospital, Adelaide 2001 - ongoing Affiliate Senior Lecturer University of Adelaide, Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Award Research Medal Australian and New Zealand Society of Respiratory Scientists - - 2012 Fellowship Fellow (designation: FANZSRS) Australia and New Zealand Society of Respiratory Scientists - - -
Education
Date Institution name Country Title 1977 - 1981 University of Melbourne Australia PhD 1976 - 1976 University of Melbourne Australia BSc(Hons) 1971 - 1973 University of Melbourne, Melbourne Australia BSc (Information & Computer Science) -
Certifications
Date Title Institution name Country 2016 FANZSRS Australian and New Zealand Society of Respiratory Scientists Australia -
Research Interests
-
Journals
-
Books
-
Book Chapters
-
Conference Papers
Year Citation 2019 Gardner, M., Donnelley, M., Parsons, D., Morgan, K., McCarron, A., & Cmielewski, P. (2019). Neural Networks provide superior detection of particles in Synchrotron X-ray images for automated Mucociliary Transport measurement. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). online: IEEE. 2019 Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers.
Scopus12019 Li, J., Quirk, B. C., Delhove, J., Kirk, R., Mc Carron, A., Cmielewski, P., . . . McLaughlin, R. A. (2019). Imaging genetically-modified cells with a miniaturised multimodal optical coherence tomography + fluorescence probem. In Proceedings of the 2019 IEEE Photonics Conference (IPC) (pp. 1-2). Piscataway, NJ: IEEE.
2019 McCarron, A., Donnelley, M., Cmielewski, P., McIntyre, C., & Parsons, D. (2019). Transient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. In MOLECULAR THERAPY Vol. 27 (pp. 209). Washington, DC: CELL PRESS. 2018 Gradl, R., Dierolf, M., Hehn, L., Gunther, B., Kutschke, D., Yang, L., . . . Morgan, K. (2018). Dynamic x-ray imaging at the Munich Compact Light Source. In Microscopy and Microanalysis Vol. 24 (pp. 350-351). Saskatoon, Canada: MIcroscopy Society of America.
2017 Jung, H., Lee, I., Lee, S., Parsons, D., & Donnelley, M. (2017). Multiple mucociliary transit marker tracking in synchrotron X-ray images using the global nearest neighbor method. In Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC' 17) Vol. 2017 (pp. 1824-1827). Online: IEEE.
Scopus2 WoS32016 McCarron, A., McIntyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2016). Development of a Clinically-Acceptable Lentiviral Vector for Cystic Fibrosis Airway Gene Therapy. In MOLECULAR THERAPY Vol. 24 (pp. S280-S281). Washington, DC: NATURE PUBLISHING GROUP.
2016 Donnelley, M., Morgan, K., Farrow, N., Siu, K., & Parsons, D. (2016). Non-invasive airway health measurement using synchrotron X-ray microscopy of high refractive index glass microbeads. In M. D. DeJonge, D. J. Paterson, & C. G. Ryan (Eds.), AIP Conference Proceedings Vol. 1696 (pp. 4 pages). Australian Synchrotron, Melbourne, AUSTRALIA: AMER INST PHYSICS.
Scopus8 WoS62016 Parsons, D., & Robar, J. (2016). Continuous Intra-Fractional Monitoring of the Prostate Using Dynamic KV Collimation and Tube Current Modulation. In MEDICAL PHYSICS Vol. 43 (pp. 3684). Washington, DC: WILEY.
WoS12012 Morgan, K., Paganin, D., Parsons, D., Donnelly, M., Yagi, N., Uesugi, K., . . . Siu, K. (2012). Single grating x-ray imaging for dynamic biological systems. In International Workshop on X-Ray and Neutron Phase Imaging with Gratings Vol. 1466 (pp. 124-129). United States: Springer New York LLC.
Scopus3 WoS32010 Donnelley, M., Parsons, D., Morgan, K., & Siu, K. (2010). Animals In synchrotrons: overcoming challenges for high-resolution, live, small-animal imaging. In K. Siu (Ed.), Proceedings of 6th International Conference on Medical Applications of Synchrotron Radiation Vol. 1266 (pp. 30-34). United States: American Institute of Physics.
Scopus17 WoS132009 Morgan, K., Paganin, D., Parsons, D., Donnelley, M., Yagi, N., Uesugi, K., . . . Siu, K. (2009). Optimising coherence properties for phase contrast x-Ray imaging (PCXI) to reveal airway surface liquid (ASL) as an airway health measure. In IFMBE Proceedings Vol. 25 (pp. 135-138). Munich, Germany: Springer Verlag.
Scopus2 WoS22009 Cmielewski, P. L., Anson, D. S., & Parsons, D. W. (2009). Six Months Lentiviral Correction of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Defect in Cystic Fibrosis Mice. In MOLECULAR THERAPY Vol. 17 (pp. S122). San Diego, CA: NATURE PUBLISHING GROUP. 2007 Kremer, K., Anson, D., & Parsons, D. (2007). Inhibition of the innate immune response to lentivirus mediated gene transfer with leptomycin B. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 530). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2007 Buckley, S., Howe, S., Sheard, V., Anson, D., Parsons, D., Thrasher, A., . . . McKay, T. (2007). Significant airway transduction after in utero administration of a gp64 pseudotyped lentiviral vector. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 526). Shine Dome Acad Sci, Canberra, AUSTRALIA: WILEY-BLACKWELL.
2007 Parsons, D., Siu, K., Williams, I., Boucher, R., Uesugi, K., & Yagi, N. (2007). Non-invasive X-ray imaging of mouse airways and organs at very high resolution - A new option for gene expression studies?. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 531-532). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2007 Liu, C., Wong, E., Tan, C. K., Anson, D., & Parsons, D. (2007). Effects of LPC pre-dosing on lentiviral gene expression in mouse lung. In JOURNAL OF GENE MEDICINE Vol. 9 (pp. 538). Shine Dome Acad Sci, Canberra, AUSTRALIA: JOHN WILEY & SONS LTD. 2005 Cmielewski, P., Parsons, D. W., Stocker, A., & Anson, D. S. (2005). In vivo airway conditioning for improved gene delivery: Mucosubstance release and lentiviral gene transfer. In JOURNAL OF GENE MEDICINE Vol. 7 (pp. 1135). Melbourne, AUSTRALIA: JOHN WILEY & SONS LTD. -
Conference Items
Year Citation 2019 Tran, H. B., Macowan, M., Abdo, A., Donnelley, M., Parsons, D., & Hodge, S. (2019). Airway inflammasome activation and dysregulated S1P signalling associated with mucus obstruction in a cystic fibrosis-like mouse model.. Poster session presented at the meeting of Respirology. Wiley. 2018 Werdiger, F., Donnelley, M., Parsons, D., Morgan, K. S., Samarage, C. R., Carnibella, R., & Fouras, A. (2018). QUANTIFICATION OF REGIONAL LUNG DISEASE IN beta-ENAC MICE USING A LABORATORY X-RAY SOURCE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 McIntyre, C., Rout-Pitt, N., Donnelley, M., & Parsons, D. (2018). LOBE SPECIFIC TARGETING OF LENTIVIRAL VECTOR GENE TRANSFER TO THE LUNGS OF ADULT RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 McIntyre, C., Cmielewski, P., Craig, F., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). CF-RELATED PATHOLOGIES ARE MORE SEVERE IN KNOCKOUT RATS COMPARED TO PHE508DEL RATS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2018 Donnelley, M., Klein, M., Hausermann, D., Hall, C., Maksimenko, A., Morgan, K., & Parsons, D. (2018). Non-invasive mucociliary transit assessment in live pig trachea. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Adelaide, Australia: Wiley.
2018 Mcintyre, C., Donnelley, M., Cmielewski, P., & Parsons, D. (2018). GENERATION OF NEW CYSTIC FIBROSIS RAT MODELS IN AUSTRALIA. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Carpentieri, C., Farrow, N., Mcintyre, C., Cmielewski, P., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2018). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS FOR CYSTIC FIBROSIS AIRWAY GENE THERAPY. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Farrow, N., Cmielewski, P., Donnelley, M., Bertoncello, I., & Parsons, D. (2018). DOES EPITHELIAL ABLATION IN THE NASAL AIRWAYS OF MICE IMPROVE STEM CELL ENGRAFTMENT?. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Donnelley, M., & Parsons, D. (2018). HOW DO WE KNOW IF CYSTIC FIBROSIS LUNG GENE THERAPY WORKS? THE IMPORTANCE OF THE RIGHT ANIMAL MODEL, AND THE RIGHT MEASUREMENT METHOD. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY. 2018 Carpentieri, C., Farrow, N., Cmielewski, P., McIntyre, C., McCarron, A., Rout-Pitt, N., . . . Donnelley, M. (2018). Airway Gene-Addition Therapy for Cystic Fibrosis: the VSV-G Pseudotype Produces Higher Transduction Levels Than HA. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. 2018 Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Bertoncello, I., & Parsons, D. (2018). Epithelial Disruption Enables Human Airway Stem Cell Transplantation in Mouse Nasal Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. 2017 Farrow, N., Donnelley, M., McIntyre, C., Rout-Pitt, N., & Parsons, D. (2017). Developing high efficiency gene transfer techniques using human air liquid interface cultures. Poster session presented at the meeting of TSANZ Poster presentations, as published in Respirology. Canberra: Wiley. 2017 McIntyre, C., Donnelley, M., Cmielewski, P., & David, P. (2017). Generation of new cystic fibrosis rat models in Australia developed using CRISPR/Cas9 genome editing. Poster session presented at the meeting of Pediatric Pulmonology. Indianapolis, Indiana: Wiley.
WoS12017 McCarron, A., Rout-Pitt, N., McIntyre, C., Donnelley, M., & Parsons, D. W. D. (2017). Lentivirus Production in Stirred-Tank and Packed-Bed Basket Bioreactor Systems: A Comparison. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. 2017 Farrow, N., Donnelley, M., Rout-Pitt, N., McIntyre, C., Bertoncello, I., & Parsons, D. W. D. (2017). High Efficiency In Vitro Transduction of Human Airway Basal Cells. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. 2017 Farrow, N., Cmielewski, P., Donnelley, M., & Parsons, D. (2017). HIGH EFFICIENCY LENTIVIRAL HUMAN AIRWAY BASAL CELL TRANSDUCTION. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2017 Carpentieri, C. L., Farrow, N., McIntyre, C., McCarron, A., Rout-Pitt, N., Parsons, D., & Donnelley, M. (2017). COMPARATIVE EFFICIENCY OF HA AND VSV-G PSEUDOTYPED LENTIVIRAL VECTORS DEVELOPED FOR TREATING CYSTIC FIBROSIS LUNG DISEASE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY. 2017 Werdiger, F., Murrie, R., Kitchen, M., Samarage, C., Carnibella, R., Fouras, A., . . . Parsons, D. (2017). Detection of regional lung disease in β-ENaC mice on a laboratory x-ray source. Poster session presented at the meeting of Abstracts of the 31st Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Indianapolis, Indiana: Wiley-Blackwell.
2016 Donnelley, M., Morgan, K., & Parsons, D. W. (2016). DIRECT X-RAY MEASUREMENT OF AIRWAY SURFACE HEALTH IN ANIMAL MODELS: AN UPDATE ON THE STATE-OF-THE-ART. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2016 Cmielewski, P., & Parsons, D. W. (2016). RAPID IN VIVO NASAL TRANSEPITHELIAL POTENTIAL DIFFERENCE MEASUREMENT IN MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V., . . . Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 McIntyre, C., Craig, F., Cmielewski, P., Donnelley, M., Farrow, N., & Parsons, D. (2015). Comparing the Efficacy of Tat-Dependent and Tat-Independent Lentiviral Vectors. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
2015 Devereux, S., Cmielewski, P., Farrow, N., & Parsons, D. (2015). Airway Pre-Treatment Enhances Mouse Lung Lentiviral Reporter Gene Expression. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
2015 Kicic, A., Ling, K., Martinovich, K., Garratt, L. W., Looi, K., Kicic-Starcevich, E., . . . Moodley, Y. (2015). CORRECTIVE EFFECTS ON AIRWAY EPITHELIAL FUNCTION BY HUMAN AMNIOTIC EPITHELIAL CELLS (HAEC) WHEN TREATING CYSTIC FIBROSIS. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Farrow, N. R., McQualter, J., Donnelley, M., Cmielewski, P., Bertoncello, I., & Parsons, D. (2015). CYSTIC FIBROSIS MOUSE MODELS DISPLAY AGE DEPENDENT AIRWAY STEM/PROGENITOR CELL HYPERPLASIA. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2015 Cmielewski, P., Parsons, D., Donnelley, M., Padmanabhan, H., Ling, K., Stick, S. M., . . . Moodley, Y. (2015). DELIVERY OF HUMAN AMNIOTIC STEM CELLS CORRECTS CFTR FUNCTION IN CF MOUSE NASAL AIRWAYS IN VIVO. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Farrow, N. R., McQualter, J. L., Donnelley, M., Bertoncello, I., & Parsons, D. W. (2014). GENE THERAPY FOR CF: IS LONG TERM EXPRESSION A CONSEQUENCE OF TRANSDUCING CONDUCTING AIRWAY ENDOGENOUS RESPIRATORY STEM CELLS?. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Padmanabhan, H., Cmielewski, P., Donnelley, M., & Parsons, D. (2014). IMPROVING THE TRANSDUCTION EFFICIENCY OF AN AEROSOL DELIVERED LENTIVIRAL VECTOR FOR CYSTIC FIBROSIS LUNG GENE THERAPY. Poster session presented at the meeting of JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY. MARY ANN LIEBERT, INC. 2014 Stahr, C. S., Samarage, C. R., Parsons, D. W., Dubsky, S., Donnelley, M., Thurgood, J., . . . Fouras, A. (2014). Regional Image Based Pulmonary Function Testing Detects Cf Lung Disease Earlier Than Conventional Pft. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. 2014 Cmielewski, P., Farrow, N., McIntyre, C., Padmanabhan, H., Donnelley, M., Kuchel, T., & Parsons, D. W. (2014). Lentiviral Airway Gene Transfer in Normal Ferrets. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: NATURE PUBLISHING GROUP. 2013 Cmielewski, P., & Parsons, D. W. (2013). CF mouse survival is improved by airway lentiviral CFTR gene transfer. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2013 Farrow, N., McQualter, J., Parsons, D., & Bertoncello, I. (2013). Endogenous stem/progenitor cell compartments of conducting airways differ in cystic fibrosis and normal mice. Poster session presented at the meeting of HUMAN GENE THERAPY. Univ London, Royal Holloway, Egham, ENGLAND: MARY ANN LIEBERT INC. 2013 Morgan, K., Donnelley, M., Fouras, A., Siu, K., & Parsons, D. (2013). Changes in airway surface liquid depth imaged after aerosolized hypertonic saline. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2013 Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N., Chua, C., Fouras, A., & Parsons, D. (2013). In-vivo changes in mucociliary transport after aerosols. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2012 Morgan, K. S., Donnelley, M., Fouras, A., Parsons, D., & Siu, K. (2012). SYNCHROTRON PHASE CONTRAST X-RAY IMAGING CAN DETECT AIRWAY SURFACE LIQUID DEPTH CHANGES FOLLOWING AEROSOLISED HYPERTONIC SALINE TREATMENT. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Siu, K., Chua, C. S., Donnelley, M., Morgan, K. S., Farrow, N., Mall, M. A., . . . Fouras, A. (2012). REGIONAL MEASURES OF LUNG FUNCTION IN THE beta-ENAC MOUSE OBTAINED USING X-RAY IMAGING VELOCIMETRY. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). Distribution, dynamics and variability of fluid doses into live mouse lungs is revealed using high resolution synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 2012 Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meetings, as published in Respirology. Canberra, Australia: Wiley-Blackwell.
2012 Parsons, D., Karen, S., Kaye, M., & Donnelley, M. (2012). High Speed X-Ray Imaging Reveals Dosed Fluid Dynamics and Fate in Mouse Nasal and Lung Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Philadelphia, PA: NATURE PUBLISHING GROUP. 2012 Cmielewski, P., & Parsons, D. W. (2012). AIRWAY LENTIVIRAL CFTR GENE TRANSFER EXTENDS THE LIFETIME OF CF MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 McQualter, J., Farrow, N., Parsons, D., & Bertoncello, I. (2012). ENDOGENOUS LUNG EPITHELIAL STEM/PROGENITOR CELL COMPARTMENTS DIFFER IN CYSTIC FIBROSIS AND NORMAL MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2012 Donnelley, M., Siu, K., Morgan, K., & Parsons, D. (2012). HIGH FRAME RATE IMAGING OF NASAL FLUID DOSING DYNAMICS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2011 Cmielewski, P., & Parsons, D. W. (2011). BIOLUMINESCENCE GENE EXPRESSION WITH A LENTIVIRAL VECTOR IN AIRWAYS OF CYSTIC FIBROSIS MICE. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2011 Donnelley, M., Siu, K. K., Morgan, K. S., & Parsons, D. W. (2011). DRY DEPOSITION OF POLLUTANT AND MARKER PARTICLES ONTO LIVE MOUSE AIRWAY SURFACES REVEALS HETEROGENEOUS MUCOCILIARY TRANSIT BEHAVIOUR. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2009 Donnelley, M. W., Morgan, K., Fouras, A., Skinner, W., Uesugi, K., Yagi, N., . . . Parsons, D. W. (2009). Individual particulate mucociliary transit analysis using synchrotron X-ray imaging. Poster session presented at the meeting of Abstracts of the 23rd Annual North American Cystic Fibrosis Conference, as published in Pediatric Pulmonology. Minneapolis, Minn.: Wiley-Liss.
2007 Liu, C., Wong, E., Tan, C., Anson, D., Smith, G., & Parsons, D. W. (2007). In-vivo mouse and sheep lung gene transfer with a VSV-G pseudotyped lentivirus vector after LPC-pretreatment. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-LISS.
Funding
NHMRC Research Funding
| 2016 | Project Grant - 1098127 | Identifying the role of airway stem cells in maintaining lentiviral mediated gene expression for cystic fibrosis lung disease | $814,272.20 |
| 2015 | Project - APP1079712 | Revolutionising the diagnosis and monitoring of CF lung disease | $792,777.95 |
| 2013 | Development Grants - APP1055116 | From the synchrotron to the clinic: translation of a novel functional lung imaging technology | $859,797.00 |
Other Research Funding
| 2015 | International - FOURAS15GI0 | CIB | USA CF Foundation | $127,000.00 |
| 2015 | Cure4CF Foundation, Ltd | CIA | Philanthropic | $152,000.00 |
| 2015 | International - PARSON15G0 | CIA | USA CF FOUNDATION | $275,000.00 |
| 2014 | Supplemental support | Team Leader, CIA | Philanthropic - Cure4CF Foundation, Scott family trust | $230,000.00 |
| 2014 | NGO's (non-profit) | CIB | Women's & Children's Hospital Foundation | $69,687.00 |
| 2013 | Supplement Support - Philanthropic | Team Leader, CIA | WCH Foundation / Scott family trust | $250,000.00 |
| 2012 | 366-13110843 - University | CIA | Centre for Stem Cell Research (CSCR) | $64,000.00 |
| 2012 | NGO's (non-profit) | CIB | WCH Foundation | $43,754.00 |
-
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Co-Supervisor Improving the effectiveness of airway lentiviral gene therapy for cystic fibrosis Doctor of Philosophy Doctorate Full Time Mrs Nikki Reyne -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2021 Principal Supervisor Overcoming Challenges to Development of a Lentiviral-Mediated Airway Gene-Addition Therapy for Cystic Fibrosis Doctor of Philosophy Doctorate Full Time Miss Alexandra Sarah Ann Mc Carron 2014 - 2014 Co-Supervisor Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Dr Chantelle McIntyre 2013 - 2019 Principal Supervisor Development of Lentiviral Airway Gene Therapy Aerosol Delivery Techniques for Cystic Fibrosis Doctor of Philosophy Doctorate Full Time Ms Harshavardini Padmanabhan 2011 - 2015 Principal Supervisor Cystic Fibrosis: The role of airway stem cells in sustained gene expression by lentiviral directed gene therapy Doctor of Philosophy Doctorate Full Time Dr Nigel Farrow 2006 - 2013 Principal Supervisor Longevity of Airway Gene Therapy for Cystic Fibrosis: Single and Repeat Lentiviral Dosing Doctor of Philosophy Doctorate Part Time Dr Patricia Lucia Cmielewski 2006 - 2010 Co-Supervisor Cystic Fibrosis Gene Therapy: Methods for the Optimisation of CFTR Gene Delivery Doctor of Philosophy Doctorate Full Time Dr Karlea Kremer 2004 - 2010 Co-Supervisor Towards Gene Therapy for Cystic Fibrosis Airway Disease: Development of a Single-Dose Lentiviral Gene Transfer for Lifetime Airway Expression Doctor of Philosophy Doctorate Part Time Ms Alice Stocker 1998 - 2003 Principal Supervisor A LENTIVIRAL GENE TRANSFER VECTOR FOR THE TREATMENT OF CYSTIC FIBROSIS AIRWAY DISEASE Doctor of Philosophy Doctorate Full Time Dr Maria Limberis
-
Committee Memberships
Date Role Committee Institution Country 2012 - ongoing Member Imaging and Medical, Programme Advisory Committee (PAC) Australian Synchrotron - 2010 - ongoing Founder Management Committee National Non-Human Primate Breeding and Research Facility - 2009 - ongoing Member Animal studies establishment committee Australian Synchrotron - 2009 - ongoing Member Australian and New Zealand Society of Respiratory Science - - -
Memberships
Date Role Membership Country 2003 - ongoing - American Society of Gene and Cell Therapy - 2003 - ongoing - Australian Gene Therapy Society - 1991 - ongoing - Australia and New Zealand Society for Respiratory Science - 1991 - ongoing - Thoracic Society of Australia and New Zealand - 1990 - ongoing - South Australian Medical Scientists Association - -
Consulting/Advisories
Date Institution Department Organisation Type Country 2009 - ongoing Australian Synchrotron - - - 2008 - 2013 American Society of Gene and Cell Therapy - - -
Connect With Me
External Profiles
